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Jeffrey Bluestone, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Phone415-514-0417
ORCID ORCID Icon0000-0001-8793-7848 Additional info
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    Other Positions
    Title(s)Professor, School of Medicine


    Collapse Biography 
    Collapse Education and Training
    Cornell Graduate School of Medical SciencePh.D.1980Immunology
    Rutgers - State UniversityM.S1977Microbiology
    Cook College, Rutgers UniversityB.S.1974Biology
    Collapse Awards and Honors
    Gould Foundation 1987  - 1989Faculty Scholar
    American Cancer Society1989Faculty Scholar
    Guggenheim Foundation1997Senior Fellowship
    Fogarty Foundation1997Senior Research Fellowship
    Cornell Medical School1998Distinguished Alumni Award
    Juvenile Diabetes Research Foundation2004Gerold & Kayla Grodsky Basic Science Award
    American Society for Transplantation2004Roche Distinguished Research Award
    Juvenile Diabetes Research Foundation2005Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award
    American Academy of Arts and Sciences2006Elected Member
    Juvenile Diabetes Research Foundation2008Scholar Award
    American Academy of Allergy, Asthma, & Immunology2010Elliott Middleton Memorial Lectureship
    National Academy of Medicine2013Elected Member
    American Society of Transplantation2015Outstanding Mentorship Award
    Federation of Clinical Immunology Societies2015President-Elect
    National Cancer Foundation2016Blue Ribbon Panel on Cancer Research (Biden Moonshot Program)

    Collapse Overview 
    Collapse Overview
    Jeffrey Bluestone, PhD, is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology and is the Director of the Hormone Research Institute in the Diabetes Center. His research over the past 25 years has focused on understanding the basic processes that control T cell activation and immune tolerance in autoimmunity and organ transplantation. He and members of his lab have developed soluble receptor antagonists; monoclonal antibodies and animals deficient in individual members of TCR and co-stimulatory pathways to define their individual roles in transplant rejection and autoimmunity including a special emphasis on a specialized subset of T cells termed “regulatory T cells” (Treg). Tregs control fundamental aspect of immune homeostasis. During the last several years, his research has adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity and under conditions of allotransplant rejection. Moreover, a strong role for antigen-specific Tregs have been found in these model systems and further evidence in humanized mice and transplant patients that alloantigen-specific Tregs are more effective. Thus, the major goal of this work is to identify the antigen-specificity of thymic- and peripherally-derived Tregs with the expectation that these TCRs can be adapted for immunotherapy. Finally, his lab initiated several projects to determine mechanisms that control Treg stability. The goal is to develop approaches using pharmacogenomics to either stabilize or destabilize Tregs in autoimmunity and cancer.

    In March 2010 Dr. Bluestone was appointed executive vice chancellor and provost at the University of California San Francisco (UCSF) serving as chief academic officer guiding the research and academic enterprise advancing the campus priorities in close collaboration with the chancellor and the campus leadership teams, and to oversee the campus ethics and compliance enterprise. Previously he served in a number of posts including Director of theUCSF Diabetes Center, as Director of the Immune Tolerance Network.

    In June 2008 Dr. Bluestone served as interim vice chancellor of research; directing the advancement of cross-campus research initiatives, such as enhancing core research facilities. In this capacity, he played a leading role in coordinating and integrating current research cores. He worked also to strengthen external research partnerships, particularly with industry, and focused on facilitating the translation of UCSF discoveries into public benefit.

    In 2009, Dr. Bluestone led the UCSF committee to strategize and secure funds available through the American Recovery and Reinvestment Act, making the campus one of the top institutional recipients in the nation of science-based stimulus funds.

    Dr. Bluestone joined the UCSF faculty in 2000. He is an international leader in the field of immunotherapy, with a stellar record of scholarly achievement and a decade of significant contributions to the research enterprise at UCSF, including the creation and directorship of an integrated UCSF Diabetes Center to focus on translating basic research in both type 1 and type 2 diabetes into improved therapies for patients. He also founded and directed the Immune Tolerance Network, a consortium of more than 1,000 of the world’s leading scientific researchers and clinical specialists from nearly 50 institutions, with the mission of testing new therapies to promote immune tolerance in transplantation, autoimmune diseases, asthma and allergic diseases.

    As a research scientist, Dr. Bluestone has helped clarify the body’s immune response on a molecular level. His systematic investigation has catalyzed recent progress in stem cell research, islet cell transplantation and immune tolerance therapies – experimentation that has formidably translated into drugs to treat human disease.

    Through his 30-year scientific career, he has authored more than 300 peer-reviewed publications that include prominent papers in Nature, Nature Immunology, and the Journal of Immunology and Diabetes. He has received numerous accolades for his work, including his 2006 election to the American Academy of Arts and Sciences, the Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation, and the distinguished alumni award from the Cornell Graduate School of Medical Science.

    Prior to joining UCSF, Bluestone was at the University of Chicago, where he was a member of the Ben May Institute for Cancer Research, rising over 13 years from an associate professor to the director of the institute. He had previously worked for seven years in various roles at the National Cancer Institute of the National Institutes of Health, ultimately becoming a senior investigator in the Immunology Branch of the National Cancer Institute.

    Dr. Bluestone earned both his BS in biology and his MS in microbiology from Rutgers State University, and his PhD in immunology from the Cornell Graduate School of Medical Science (Sloan-Kettering Division).

    Collapse Research 
    Collapse Research Activities and Funding
    Designer Tregs for restoring tolerance in patients with type 1 diabetes
    NIH/NIDDK UC4DK116264Sep 20, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK R01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK U01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Co-Principal Investigator
    Disruption of T cell tolerance in type 1 diabetes
    NIH/NIAID P01AI118688Jun 8, 2016 - May 31, 2021
    Role: Co-Investigator
    Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation
    NIH/NIAID U01AI110658Jun 1, 2014 - May 31, 2019
    Role: Co-Principal Investigator
    Autoimmunity Center of Excellence Clinical Research Program
    NIH/NIAID UM1AI110498May 1, 2014 - Apr 30, 2020
    Role: Co-Investigator
    Role of Innate Lymphoid Cells in Autoimmunity
    NIH/NIAID R21AI107328Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation"
    NIH/NIAID R34AI095135Apr 1, 2012 - Mar 31, 2014
    Role: Co-Principal Investigator
    "Expanding beta-cell mass"
    NIH/NIDDK U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Spontaneous Autoimmune Model of Peripheral Neuropathy
    NIH/NIAID R01AI050834Aug 2, 2010 - Nov 30, 2012
    Role: Principal Investigator
    Role of Notch 1 in Immune Tolerance
    NIH/NIAID R21AI059979Apr 1, 2004 - Mar 31, 2007
    Role: Principal Investigator
    Autoimmunity Center of Excellence
    NIH/NIAID U19AI056388Sep 30, 2003 - Mar 31, 2009
    Role: Co-Investigator
    Diabetes Research Center
    NIH/NIDDK P30DK063720May 1, 2003 - Mar 31, 2020
    Role: Co-Principal Investigator
    Conf on Mechanism and Applications of Immune Tolerance
    NIH/NIAID R13AI051294Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    Immune tolerance network: lung transplantation
    NIH/NIAID N01AI15416-20-0-10Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: liver transplantation
    NIH/NIAID N01AI15416-20-0-11Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Systemic lupus rythematosus (SLE)
    NIH/NIAID N01AI15416-20-0-12Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Kidney, Liver and Bone Marrow Transplantation
    NIH/NIAID N01AI15416-20-0-2Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Food Allergy
    NIH/NIAID N01AI15416-20-0-3Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Type 1 diabetes
    NIH/NIAID N01AI15416-20-0-4Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Multiple sclerosis
    NIH/NIAID N01AI15416-20-0-5Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Rheumatoid arthritis
    NIH/NIAID N01AI15416-20-0-6Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Autoimmune diseases: Vasculitis
    NIH/NIAID N01AI15416-20-0-7Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Islet cell transplantation
    NIH/NIAID N01AI15416-20-0-8Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: heart tranplantation
    NIH/NIAID N01AI15416-20-0-9Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: liver transplantation
    NIH N01AI15416-23-0-11Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Systemic lupus rythematosus (SLE)
    NIH N01AI15416-23-0-12Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: kidney transplantation
    NIH N01AI15416-23-0-13Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    IImmune Tolerance Network: Airborne Allergens and Allergic Rhintitis
    NIH N01AI15416-23-0-14Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Food Allergy
    NIH N01AI15416-23-0-3Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Type 1 diabetes
    NIH N01AI15416-23-0-4Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Multiple sclerosis
    NIH N01AI15416-23-0-5Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    FASEB SUMMER CONFERENCE--LYMPHOCYTES AND ANTIBODIES
    NIH/NIAID R13AI047114Jun 1, 2000 - May 31, 2001
    Role: Principal Investigator
    Immunomodulation of transplant rejection by Anti-CD3 mAb
    NIH/NIAID R01AI046643Mar 1, 2000 - May 31, 2016
    Role: Principal Investigator
    IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB
    NIH/NIAID R37AI046643Mar 1, 2000 - Feb 28, 2011
    Role: Principal Investigator
    MOFLO MULTILASER FLOW CYTOMETER
    NIH/NCRR S10RR014884Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    COLLABORATIVE NETWORK FOR CLINICAL RES ON IMMUNE TOLERAN
    NIH/NIAID N01AI095380Sep 30, 1999 - Sep 29, 2006
    Role: Principal Investigator
    TOLERANCE OF ISLET CELL GRAFT
    NIH/NIDDK R01DK055351Jun 15, 1999 - May 31, 2003
    Role: Principal Investigator
    CTLA 4 ANTAGONISM DURING T CELL ACTIVATION
    NIH/NIAID F33AI009895Mar 22, 1998
    Role: Principal Investigator
    SCOR in Cellular and Molecular Mechanisms of Asthma
    NIH/NHLBI P50HL056399Sep 1, 1997 - Aug 31, 2006
    Role: Co-Principal Investigator
    IMMUNOREGULATION OF IDDM
    NIH P01DK049799Jun 15, 1995 - May 31, 2000
    Role: Co-Investigator
    COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    NIH/NIAID P01AI035294Sep 1, 1993 - Jun 30, 1997
    Role: Principal Investigator
    IMMUNOMODULATION OF TRANSPLANT REJECTION
    NIH/NIAID P01AI029531Jun 1, 1990 - Sep 29, 1995
    Role: Principal Investigator
    IMMUNOBIOLOGY OF TCR GAMMA/DELTA T-CELLS
    NIH/NIAID R01AI026847Sep 1, 1988 - Aug 31, 1999
    Role: Principal Investigator
    IN VIVO POTENTIATION OF IMMUNE RESPONSES
    NIH/NCI R01CA049260Aug 5, 1988 - Jul 31, 1995
    Role: Principal Investigator
    Interdisciplinary Training Program in Immunology
    NIH/NIAID T32AI007090Jul 1, 1979 - Jun 30, 2024
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA014599Feb 1, 1977 - Mar 31, 2018
    Role: Co-Investigator
    IMMUNITY AND CANCER
    NIH P01CA019266Jun 1, 1976 - Mar 31, 1996
    Role: Co-Investigator
    Immune Tolerance and Autoimmunity
    NIH/NIAID P01AI035297Sep 30, 1999
    Role: Co-Investigator
    Immune Tolerance Network: Autoimmune Diseases
    NIH/NIAID N01AI15416
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet. 2020 05 23; 395(10237):1627-1639. Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, Juerchott K, Braudeau C, James B, Contreras-Ruiz L, van der Net JB, Bergler T, Caldara R, Petchey W, Edinger M, Dupas N, Kapinsky M, Mutzbauer I, Otto NM, Öllinger R, Hernandez-Fuentes MP, Issa F, Ahrens N, Meyenberg C, Karitzky S, Kunzendorf U, Knechtle SJ, Grinyó J, Morris PJ, Brent L, Bushell A, Turka LA, Bluestone JA, Lechler RI, Schlitt HJ, Cuturi MC, Schlickeiser S, Friend PJ, Miloud T, Scheffold A, Secchi A, Crisalli K, Kang SM, Hilton R, Banas B, Blancho G, Volk HD, Lombardi G, Wood KJ, Geissler EK. PMID: 32446407.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. 2020 Apr 29. Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, Prator GY, Zhang B, Lee Y, Sun Z, Ifergan I, Van Gool F, Hargreaves DC, Bluestone JA, Marson A, Fang D. PMID: 32499641.
      View in: PubMed   Mentions:    Fields:    
    3. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 Apr 30; 181(3):728-744.e21. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591.
      View in: PubMed   Mentions: 1     Fields:    
    4. Accelerating the development of innovative cellular therapy products for the treatment of cancer. Cytotherapy. 2020 May; 22(5):239-246. Stewart MD, Keane A, Butterfield LH, Levine BL, Thompson B, Xu Y, Ramsborg C, Lee A, Kalos M, Koerner C, Moore T, Markovic I, Lasiter L, Ibrahim R, Bluestone J, Sigal E, Allen J. PMID: 32199724.
      View in: PubMed   Mentions:    Fields:    
    5. Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R a-Chain Expression. J Immunol. 2020 Feb 15; 204(4):747-751. Mufazalov IA, Andruszewski D, Schelmbauer C, Heink S, Blanfeld M, Masri J, Tang Y, Schüler R, Eich C, Wunderlich FT, Karbach SH, Bluestone JA, Korn T, Waisman A. PMID: 31924653.
      View in: PubMed   Mentions:    Fields:    
    6. New Frontiers in the Treatment of Type 1 Diabetes. Cell Metab. 2020 Jan 07; 31(1):46-61. Warshauer JT, Bluestone JA, Anderson MS. PMID: 31839487.
      View in: PubMed   Mentions:    Fields:    
    7. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat Biotechnol. 2020 01; 38(1):44-49. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. PMID: 31819258.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Treg cell-based therapies: challenges and perspectives. Nat Rev Immunol. 2020 03; 20(3):158-172. Raffin C, Vo LT, Bluestone JA. PMID: 31811270.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model. PLoS One. 2019; 14(10):e0217728. Holohan DR, Van Gool F, Bluestone JA. PMID: 31647813.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Next-generation regulatory T cell therapy. Nat Rev Drug Discov. 2019 10; 18(10):749-769. Ferreira LMR, Muller YD, Bluestone JA, Tang Q. PMID: 31541224.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 08 15; 381(7):603-613. Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ. PMID: 31180194.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCellsCTClinical Trials
    12. NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87. Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.
      View in: PubMed   Mentions: 1     Fields:    
    13. A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity. 2019 02 19; 50(2):362-377.e6. Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. PMID: 30709738.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 03; 71(3):431-440. Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandova PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, Rosenblum MD. PMID: 30277008.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer. Front Med (Lausanne). 2018; 5:351. Bridge JA, Lee JC, Daud A, Wells JW, Bluestone JA. PMID: 30631766.
      View in: PubMed   Mentions:
    16. The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy. Cancer Immunol Res. 2018 12; 6(12):1445-1452. Young A, Quandt Z, Bluestone JA. PMID: 30510057.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    17. Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again. Genome Med. 2018 10 31; 10(1):79. Bucktrout SL, Bluestone JA, Ramsdell F. PMID: 30376867.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier. J Allergy Clin Immunol. 2018 12; 142(6):1710-1718. Esensten JH, Muller YD, Bluestone JA, Tang Q. PMID: 30367909.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Treg cells-the next frontier of cell therapy. Science. 2018 10 12; 362(6411):154-155. Bluestone JA, Tang Q. PMID: 30309932.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Chance favours the prepared mind. Nat Rev Immunol. 2018 09; 18(9):541. Bluestone JA. PMID: 30018454.
      View in: PubMed   Mentions:    Fields:    
    21. Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. J Immunol. 2018 10 01; 201(7):2094-2106. Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC. PMID: 30104245.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Revisiting IL-2: Biology and therapeutic prospects. Sci Immunol. 2018 07 06; 3(25). Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA. PMID: 29980618.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2018 07; 559(7715):E13. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 29899441.
      View in: PubMed   Mentions:    Fields:    
    24. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018 07; 24(7):1005-1014. Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA. PMID: 29942088.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors. Diabetes. 2018 08; 67(8):1471-1480. Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC. PMID: 29937434.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    26. Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. Cell Rep. 2018 06 12; 23(11):3262-3274. Wang D, Quiros J, Mahuron K, Pai CC, Ranzani V, Young A, Silveria S, Harwin T, Abnousian A, Pagani M, Rosenblum MD, Van Gool F, Fong L, Bluestone JA, DuPage M. PMID: 29898397.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Pathological conversion of regulatory T cells is associated with loss of allotolerance. Sci Rep. 2018 05 04; 8(1):7059. Hua J, Inomata T, Chen Y, Foulsham W, Stevenson W, Shiang T, Bluestone JA, Dana R. PMID: 29728574.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Proc Natl Acad Sci U S A. 2018 05 15; 115(20):5265-5270. Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q. PMID: 29712852.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018 03 02; 359(6379):1037-1042. Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. PMID: 29496879.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
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    96. The future of cancer treatment: will it include immunotherapy? Cancer Cell. 2012 Jul 10; 22(1):7-8. Bluestone JA, Small EJ. PMID: 22789534.
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    259. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. J Exp Med. 2001 Jun 04; 193(11):1327-32. Wu Q, Salomon B, Chen M, Wang Y, Hoffman LM, Bluestone JA, Fu YX. PMID: 11390440.
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    260. Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells. J Immunol. 2001 Jun 01; 166(11):6491-9. Donepudi M, Raychaudhuri P, Bluestone JA, Mokyr MB. PMID: 11359799.
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    261. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2001 Jun; 21(6):1011-6. Reardon CA, Blachowicz L, White T, Cabana V, Wang Y, Lukens J, Bluestone J, Getz GS. PMID: 11397712.
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    262. The Immune Tolerance Network: tolerance at the crossroads. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):773-6. Bluestone JA, Matthews J. PMID: 11375080.
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    263. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant. 2001 May; 1(1):38-46. Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newel KA, Thistlethwaite JR, Bluestone JA, Alegre ML. PMID: 12095035.
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    264. Development and applications of surface-linked single chain antibodies against T-cell antigens. J Immunol Methods. 2001 Feb 01; 248(1-2):77-90. Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA. PMID: 11223070.
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    265. Transplantation and the CD28/CTLA4/B7 pathway. Transplant Proc. 2001 Feb-Mar; 33(1-2):209-11. Alegre M, Fallarino F, Zhou P, Frauwirth K, Thistlethwaite J, Newell K, Gajewski T, Bluestone J. PMID: 11266782.
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    266. Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig. Transplant Proc. 2001 Feb-Mar; 33(1-2):214-6. Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M. PMID: 11266784.
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    267. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol. 2001; 19:225-52. Salomon B, Bluestone JA. PMID: 11244036.
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    268. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000 Nov 15; 165(10):5580-7. Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML. PMID: 11067913.
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    269. The immune tolerance network: the "Holy Grail" comes to the clinic. J Am Soc Nephrol. 2000 Nov; 11(11):2141-6. Bluestone JA, Matthews JB, Krensky AM. PMID: 11053493.
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    270. CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol. 2000 Sep 22; 109(2):173-80. Karandikar NJ, Eagar TN, Vanderlugt CL, Bluestone JA, Miller SD. PMID: 10996219.
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    271. The immune tolerance network--an NIH/JDF-supported initiative to bring tolerance research into the clinic: a major new resource for clinical immunologists. Clin Immunol. 2000 Sep; 96(3):171-3. Bluestone JA, Matthews JB. PMID: 10964534.
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    272. CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease. J Virol. 2000 Sep; 74(18):8349-57. Neville KL, Dal Canto MC, Bluestone JA, Miller SD. PMID: 10954534.
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    273. Evidence for functional relevance of CTLA-4 in ultraviolet-radiation-induced tolerance. J Immunol. 2000 Aug 15; 165(4):1824-31. Schwarz A, Beissert S, Grosse-Heitmeyer K, Gunzer M, Bluestone JA, Grabbe S, Schwarz T. PMID: 10925260.
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    274. Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells. J Immunol. 2000 Jun 15; 164(12):6230-6. Sojka DK, Donepudi M, Bluestone JA, Mokyr MB. PMID: 10843675.
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    275. Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152). J Immunol. 2000 May 01; 164(9):4433-42. Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, Fallarino F, Collins M, Segal DM, Gajewski TF, Kranz DM, Bluestone JA. PMID: 10779742.
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    276. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000 Apr; 12(4):431-40. Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. PMID: 10795741.
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    277. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation. 2000 Mar 15; 69(5):904-9. Szot GL, Zhou P, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR. PMID: 10755548.
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    278. In vitro characterization of five humanized OKT3 effector function variant antibodies. Cell Immunol. 2000 Feb 25; 200(1):16-26. Xu D, Alegre ML, Varga SS, Rothermel AL, Collins AM, Pulito VL, Hanna LS, Dolan KP, Parren PW, Bluestone JA, Jolliffe LK, Zivin RA. PMID: 10716879.
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    279. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. J Immunol. 2000 Jan 15; 164(2):670-8. Vanderlugt CL, Neville KL, Nikcevich KM, Eagar TN, Bluestone JA, Miller SD. PMID: 10623809.
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    280. Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol. 2000 Jan 01; 164(1):308-18. Korthäuer U, Nagel W, Davis EM, Le Beau MM, Menon RS, Mitchell EO, Kozak CA, Kolanus W, Bluestone JA. PMID: 10605025.
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    281. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. J Immunol. 2000 Jan 01; 164(1):136-43. Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD. PMID: 10605004.
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    282. Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation. J Immunol. 1999 Dec 15; 163(12):6725-31. Beissert S, Bluestone JA, Mindt I, Voskort M, Metze D, Mehling A, Luger TA, Schwarz T, Grabbe S. PMID: 10586070.
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    283. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 1999 Dec 06; 190(11):1657-68. Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA. PMID: 10587356.
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    284. CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice. Am J Respir Cell Mol Biol. 1999 Oct; 21(4):498-509. Mathur M, Herrmann K, Qin Y, Gulmen F, Li X, Krimins R, Weinstock J, Elliott D, Bluestone JA, Padrid P. PMID: 10502560.
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    285. Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection. Transplantation. 1999 Sep 15; 68(5):608-16. Woodle ES, Xu D, Zivin RA, Auger J, Charette J, O'Laughlin R, Peace D, Jollife LK, Haverty T, Bluestone JA, Thistlethwaite JR. PMID: 10507477.
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    286. Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells. J Immunol. 1999 Sep 01; 163(5):2358-62. Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA. PMID: 10452966.
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    287. Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis). Transplantation. 1999 Aug 15; 68(3):331-7. Theriault BR, Thistlethwaite JR, Levisetti MG, Wardrip CL, Szot G, Bruce DS, Rilo H, Li X, Gray GS, Bluestone JA, Padrid PA. PMID: 10459535.
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    288. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol. 1999 May 15; 162(10):5784-91. Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. PMID: 10229811.
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    289. Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4. Cancer Res. 1999 May 01; 59(9):2096-101. Richards J, Auger J, Peace D, Gale D, Michel J, Koons A, Haverty T, Zivin R, Jolliffe L, Bluestone JA. PMID: 10232594.
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    290. Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism. J Immunol. 1999 Apr 15; 162(8):4817-23. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. PMID: 10202025.
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    291. CD2 and CD3 receptor-mediated tolerance: constraints on T cell activation. Transplantation. 1999 Mar 15; 67(5):741-8. Punch JD, Lin J, Bluestone J, Bromberg JS. PMID: 10096532.
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    292. TCRgammadelta cells and viruses. Microbes Infect. 1999 Mar; 1(3):203-12. Sciammas R, Bluestone JA. PMID: 10801231.
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    293. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol. 1999 Feb 01; 162(3):1270-7. Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB. PMID: 9973379.
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    294. Activation and peripheral expansion of murine T-cell receptor gamma delta intraepithelial lymphocytes. Gastroenterology. 1999 Feb; 116(2):327-34. Guehler SR, Bluestone JA, Barrett TA. PMID: 9922313.
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    295. The CTLA-4 gene is expressed in placental fibroblasts. Mol Hum Reprod. 1999 Jan; 5(1):84-7. Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C. PMID: 10050667.
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    296. Molecular basis of T cell inactivation by CTLA-4. Science. 1998 Dec 18; 282(5397):2263-6. Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA. PMID: 9856951.
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    297. Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells. J Immunol. 1998 Dec 15; 161(12):6552-8. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. PMID: 9862681.
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    298. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res. 1998 Dec 01; 58(23):5301-4. Mokyr MB, Kalinichenko T, Gorelik L, Bluestone JA. PMID: 9850053.
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    299. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. J Immunol. 1998 Nov 15; 161(10):5187-92. Sciammas R, Bluestone JA. PMID: 9820489.
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    300. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol. 1998 Nov 15; 161(10):5138-42. Salomon B, Bluestone JA. PMID: 9820482.
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    301. Signalling through the TCR. Res Immunol. 1998 Nov-Dec; 149(9):866-7. Cantrell D, Bluestone J, Vivier E, Tybulewicz V. PMID: 9923642.
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    302. Cell fate in the immune system: decisions, decisions, decisions. Immunol Rev. 1998 Oct; 165:5-12. Bluestone JA. PMID: 9850847.
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    303. Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease. J Neuroimmunol. 1998 Aug 14; 89(1-2):10-8. Karandikar NJ, Vanderlugt CL, Bluestone JA, Miller SD. PMID: 9726820.
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    304. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol. 1998 Aug 01; 161(3):1516-24. Ma Y, Thornton S, Duwel LE, Boivin GP, Giannini EH, Leiden JM, Bluestone JA, Hirsch R. PMID: 9686619.
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    305. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunol Rev. 1998 Aug; 164:63-72. Vanderlugt CL, Begolka WS, Neville KL, Katz-Levy Y, Howard LM, Eagar TN, Bluestone JA, Miller SD. PMID: 9795764.
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    306. Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. J Immunol. 1998 Jul 01; 161(1):192-9. Karandikar NJ, Vanderlugt CL, Eagar T, Tan L, Bluestone JA, Miller SD. PMID: 9647224.
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    307. Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience. Transplant Proc. 1998 Jun; 30(4):1369-70. Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR. PMID: 9636555.
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    308. Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes. J Immunol. 1998 Jun 01; 160(11):5341-6. Guehler SR, Finch RJ, Bluestone JA, Barrett TA. PMID: 9605133.
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    309. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J Exp Med. 1998 May 18; 187(10):1699-709. Chau LA, Bluestone JA, Madrenas J. PMID: 9584148.
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    310. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol. 1998 May 15; 160(10):4841-9. Smith JA, Tang Q, Bluestone JA. PMID: 9590231.
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    311. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J Immunol. 1998 Apr 15; 160(8):3855-60. Walunas TL, Bluestone JA. PMID: 9558090.
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    312. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):453-62. Padrid PA, Mathur M, Li X, Herrmann K, Qin Y, Cattamanchi A, Weinstock J, Elliott D, Sperling AI, Bluestone JA. PMID: 9533932.
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    313. Importance of the B7-2 molecule for low dose melphalan-induced acquisition of tumor-eradicating immunity by mice bearing a large MOPC-315 tumor. J Immunol. 1998 Feb 15; 160(4):1866-74. Mokyr MB, Kalinichenko TV, Gorelik L, Bluestone JA. PMID: 9469448.
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    314. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol. 1997 Dec 01; 159(11):5187-91. Levisetti MG, Padrid PA, Szot GL, Mittal N, Meehan SM, Wardrip CL, Gray GS, Bruce DS, Thistlethwaite JR, Bluestone JA. PMID: 9548454.
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    315. Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE. J Neuroimmunol. 1997 Nov; 79(2):113-8. Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD. PMID: 9394783.
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    316. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol. 1997 Nov 01; 159(9):4150-3. Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA. PMID: 9379007.
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    317. Transplantation tolerance--putting the pieces together. Curr Opin Immunol. 1997 Oct; 9(5):631-3. Lechler R, Bluestone JA. PMID: 9368770.
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    318. T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. Curr Opin Immunol. 1997 Oct; 9(5):648-54. Smith JA, Bluestone JA. PMID: 9368773.
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    319. Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res. 1997 Sep 15; 57(18):4036-41. Yang YF, Zou JP, Mu J, Wijesuriya R, Ono S, Walunas T, Bluestone J, Fujiwara H, Hamaoka T. PMID: 9307290.
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    320. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med. 1997 Jul 21; 186(2):229-38. Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H. PMID: 9221752.
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    321. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. J Immunol. 1997 Jul 01; 159(1):86-91. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. PMID: 9200442.
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    322. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. PMID: 9166426.
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    323. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J Exp Med. 1997 Apr 21; 185(8):1413-22. Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA. PMID: 9126922.
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    324. Is CTLA-4 a master switch for peripheral T cell tolerance? J Immunol. 1997 Mar 01; 158(5):1989-93. Bluestone JA. PMID: 9036940.
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    325. Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J Immunol. 1997 Mar 01; 158(5):2156-64. Woodle ES, Smith DM, Bluestone JA, Kirkman WM, Green DR, Skowronski EW. PMID: 9036961.
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    326. CD28/B7 regulation of autoimmune diabetes. Immunol Res. 1997 Feb; 16(1):71-84. Herold KG, Lenschow DJ, Bluestone JA. PMID: 9048209.
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    327. Class I MHC mediates programmed cell death in a Fas-independent manner. Transplant Proc. 1997 Feb-Mar; 29(1-2):1101. Woodle ES, Smith DM, Bluestone JA, Green DR, Skowronski EW. PMID: 9123218.
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    328. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med. 1997 Jan 20; 185(2):219-29. Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. PMID: 9016871.
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    329. CD28 costimulation promotes the production of Th2 cytokines. J Immunol. 1997 Jan 15; 158(2):658-65. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. PMID: 8992981.
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    330. CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. J Immunol. 1997 Jan 15; 158(2):984-91. Herold KC, Vezys V, Koons A, Lenschow D, Thompson C, Bluestone JA. PMID: 8993020.
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    331. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J Immunol. 1996 Nov 01; 157(9):3909-17. Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA. PMID: 8892622.
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    332. The complexities of T-cell co-stimulation: CD28 and beyond. Immunol Rev. 1996 Oct; 153:155-82. Sperling AI, Bluestone JA. PMID: 9010723.
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    333. TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen. J Immunol. 1996 Sep 15; 157(6):2320-7. Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA. PMID: 8805629.
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    334. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 1996 Sep; 5(3):285-93. Lenschow DJ, Herold KC, Rhee L, Patel B, Koons A, Qin HY, Fuchs E, Singh B, Thompson CB, Bluestone JA. PMID: 8808683.
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    335. Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts. J Exp Med. 1996 Aug 01; 184(2):493-503. Guehler SR, Bluestone JA, Barrett TA. PMID: 8760803.
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    336. CTLA-4: a negative regulator of autoimmune disease. J Exp Med. 1996 Aug 01; 184(2):783-8. Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA. PMID: 8760834.
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    337. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med. 1996 Jun 01; 183(6):2541-50. Walunas TL, Bakker CY, Bluestone JA. PMID: 8676075.
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    338. Regulation of CTLA-4 expression during T cell activation. J Immunol. 1996 Jun 01; 156(11):4154-9. Perkins D, Wang Z, Donovan C, He H, Mark D, Guan G, Wang Y, Walunas T, Bluestone J, Listman J, Finn PW. PMID: 8666782.
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    339. Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens. Blood. 1996 May 15; 87(10):4463-72. Blazar BR, Taylor PA, Bluestone JA, Vallera DA. PMID: 8639809.
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    340. In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells. Transplantation. 1996 Mar 15; 61(5):798-803. Woodle ES, Hussein S, Bluestone JA. PMID: 8607186.
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    341. Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule. Cancer Immunol Immunother. 1996 Mar; 42(3):161-9. La Motte RN, Rubin MA, Barr E, Leiden JM, Bluestone JA, Mokyr MB. PMID: 8640844.
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    342. Costimulation and its role in organ transplantation. Clin Transplant. 1996 Feb; 10(1 Pt 2):104-9. Bluestone JA. PMID: 8680045.
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    343. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol. 1996 Feb 01; 156(3):1006-13. Walunas TL, Sperling AI, Khattri R, Thompson CB, Bluestone JA. PMID: 8557973.
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    344. IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. J Immunol. 1996 Jan 15; 156(2):663-9. Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y. PMID: 8543818.
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    345. Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens. Blood. 1996 Jan 15; 87(2):827-37. Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Barrett TA, Bluestone JA, Vallera DA. PMID: 8555509.
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    346. CD28/B7 system of T cell costimulation. Annu Rev Immunol. 1996; 14:233-58. Lenschow DJ, Walunas TL, Bluestone JA. PMID: 8717514.
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    347. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity. 1995 Dec; 3(6):739-45. Miller SD, Vanderlugt CL, Lenschow DJ, Pope JG, Karandikar NJ, Dal Canto MC, Bluestone JA. PMID: 8777719.
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    348. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies. Transplantation. 1995 Nov 27; 60(10):1171-8. Lenschow DJ, Zeng Y, Hathcock KS, Zuckerman LA, Freeman G, Thistlethwaite JR, Gray GS, Hodes RJ, Bluestone JA. PMID: 7482727.
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    349. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995 Nov; 3(5):541-7. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. PMID: 7584144.
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    350. Development of TCR gamma delta iIELs. Semin Immunol. 1995 Oct; 7(5):299-305. Barrett TA, Bluestone JA. PMID: 8580462.
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    351. Transplantation. Curr Opin Immunol. 1995 Oct; 7(5):617-9. Bluestone JA, Lechler RI. PMID: 8573302.
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    352. Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent. J Immunol. 1995 Sep 01; 155(5):2379-86. Kaliyaperumal A, Falchetto R, Cox A, Dick R, Shabanowitz J, Chien YH, Matis L, Hunt DF, Bluestone JA. PMID: 7650372.
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    353. Ly-6C is a marker of memory CD8+ T cells. J Immunol. 1995 Aug 15; 155(4):1873-83. Walunas TL, Bruce DS, Dustin L, Loh DY, Bluestone JA. PMID: 7543536.
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    354. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol. 1995 Aug 01; 155(3):1544-55. Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA. PMID: 7636216.
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    355. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol. 1995 Aug 01; 155(3):1032-6. Kearney ER, Walunas TL, Karr RW, Morton PA, Loh DY, Bluestone JA, Jenkins MK. PMID: 7543510.
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    356. Two waves of gamma delta T cells expressing different V delta genes are recruited into schistosome-induced liver granulomas. J Immunol. 1995 Jul 01; 155(1):275-84. Sandor M, Sperling AI, Cook GA, Weinstock JV, Lynch RG, Bluestone JA. PMID: 7602105.
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    357. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995 Jul 01; 182(1):139-46. Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB. PMID: 7790813.
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    358. New perspectives of CD28-B7-mediated T cell costimulation. Immunity. 1995 Jun; 2(6):555-9. Bluestone JA. PMID: 7540940.
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    359. T cell costimulation through the CD28 receptor. Proc Assoc Am Physicians. 1995 Apr; 107(1):41-6. Green JM, Noel PJ, Sperling AI, Walunas TL, Lenschow DJ, Stack R, Gray GS, Bluestone JA, Thompson CB. PMID: 8630743.
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    360. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med. 1995 Mar 01; 181(3):1145-55. Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA. PMID: 7532678.
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    361. Inhibition of T-cell activation by an anti-human class I MHC reactive monoclonal antibody occurs at a point distal to TCR-CD3 mediated signal transduction. Transplant Proc. 1995 Feb; 27(1):395-7. Smith DM, Bluestone JA, Thistlethwaite JR, Woodle ES. PMID: 7879035.
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    362. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27; 270(4):1928-34. Hu Q, Davidson D, Schwartzberg PL, Macchiarini F, Lenardo MJ, Bluestone JA, Matis LA. PMID: 7829530.
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    363. Programmed differentiation of murine thymocytes during fetal thymus organ culture. J Immunol Methods. 1995 Jan 13; 178(1):13-29. DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. PMID: 7829862.
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    364. Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors. Dig Dis Sci. 1995 Jan; 40(1):58-64. Alegre ML, Lenschow DJ, Bluestone JA. PMID: 7821120.
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    365. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol. 1995; 11:307-53. Bluestone JA, Khattri R, Sciammas R, Sperling AI. PMID: 8689560.
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    366. Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication. J Immunol. 1994 Oct 01; 153(7):3123-34. Mokyr MB, Prokhorova A, Rubin M, Bluestone JA. PMID: 8089490.
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    367. Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies. Transplantation. 1994 Sep 27; 58(6):681-9. Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA. PMID: 7940687.
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    368. Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol. 1994 Sep 15; 153(6):2738-49. Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR. PMID: 8077678.
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    369. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol. 1994 Sep 01; 153(5):1990-7. Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA. PMID: 7519638.
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    370. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1994 Sep; 1(6):501-8. Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, Thompson CB. PMID: 7534617.
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    371. Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules. J Immunol. 1994 Aug 01; 153(3):1054-67. Smith DM, Bluestone JA, Jeyarajah DR, Newberg MH, Engelhard VH, Thistlethwaite JR, Woodle ES. PMID: 7913109.
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    372. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994 Aug; 1(5):405-13. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. PMID: 7882171.
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    373. The B7 and CD28 receptor families. Immunol Today. 1994 Jul; 15(7):321-31. June CH, Bluestone JA, Nadler LM, Thompson CB. PMID: 7522010.
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    374. Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model. Transplantation. 1994 Jun 27; 57(12):1786-94. Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA. PMID: 8016885.
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    375. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 1994 Jun 15; 57(11):1537-43. Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. PMID: 8009586.
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    376. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J Immunol. 1994 Jun 15; 152(12):5723-33. Stack RM, Lenschow DJ, Gray GS, Bluestone JA, Fitch FW. PMID: 7515912.
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    377. Prolongation of human pancreatic islet xenografts by pretreatment of islets with anti-human ICAM-1 monoclonal antibody. Transplant Proc. 1994 Jun; 26(3):1120. Zeng Y, Torres MA, Thistlethwaite JR, Montag A, Bluestone JA. PMID: 7913254.
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    378. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol. 1994 Jun 01; 152(11):5392-7. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA. PMID: 8189058.
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    379. Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases. J Immunol. 1994 Apr 01; 152(7):3522-9. Rubin M, Bluestone JA, Newell KA, Prokhorova A, Mokyr MB. PMID: 8144932.
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    380. The nature of major histocompatibility complex recognition by gamma delta T cells. Cell. 1994 Jan 14; 76(1):29-37. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH. PMID: 8287478.
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    381. TCR gamma delta cells: mysterious cells of the immune system. Immunol Res. 1994; 13(4):268-79. Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA. PMID: 7616054.
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    382. Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture. Thymus. 1994-1995; 23(3-4):131-53. Tatsumi Y, Deluca D, Cron RQ, Bluestone JA. PMID: 8525502.
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    383. The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11875-9. Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, Fitch FW. PMID: 8265641.
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    384. Role of gamma delta T cells in murine collagen-induced arthritis. J Immunol. 1993 Dec 01; 151(11):6546-58. Peterman GM, Spencer C, Sperling AI, Bluestone JA. PMID: 8245484.
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    385. T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas. Cell Immunol. 1993 Dec; 152(2):305-22. Sydora BC, Mixter PF, Houlden B, Hershberg R, Levy R, Comay M, Bluestone J, Kronenberg M. PMID: 8258140.
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    386. CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes. J Immunol. 1993 Dec 01; 151(11):6043-50. Sperling AI, Linsley PS, Barrett TA, Bluestone JA. PMID: 8245449.
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    387. Expression and functional significance of an additional ligand for CTLA-4. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11054-8. Lenschow DJ, Su GH, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miller J, Bluestone JA. PMID: 7504292.
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    388. Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan. J Immunol. 1993 Nov 01; 151(9):4838-46. Mokyr MB, Rubin M, Newell KA, Prokhorova A, Bluestone JA. PMID: 8409442.
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    389. Peptide-induced changes in class I heavy chains alter allorecognition. J Immunol. 1993 Oct 15; 151(8):3943-53. Bluestone JA, Kaliyaperumal A, Jameson S, Miller S, Dick R. PMID: 8409378.
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    390. Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes. Eur J Immunol. 1993 Oct; 23(10):2482-7. Dent AL, Matis LA, Bluestone JA, Hedrick SM. PMID: 8405049.
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    391. T cell co-stimulation and in vivo tolerance. Curr Opin Immunol. 1993 Oct; 5(5):747-52. Lenschow DJ, Bluestone JA. PMID: 7694594.
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    392. Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation. J Immunol. 1993 Sep 15; 151(6):3030-41. Tatsumi Y, Pena JC, Matis L, Deluca D, Bluestone JA. PMID: 8376767.
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    393. Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):6949-51. Sherman LA, Chattopadhyay S, Biggs JA, Dick RF, Bluestone JA. PMID: 8346201.
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    394. Tolerance of T cell receptor gamma/delta cells in the intestine. J Exp Med. 1993 Jun 01; 177(6):1755-62. Barrett TA, Tatsumi Y, Bluestone JA. PMID: 8098732.
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    395. Non-classical MHC molecules: the first line of defence? Curr Biol. 1993 May 01; 3(5):294-6. Sperling AI, Bluestone JA. PMID: 15335753.
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    396. Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. J Exp Med. 1993 Apr 01; 177(4):1061-70. Wells FB, Tatsumi Y, Bluestone JA, Hedrick SM, Allison JP, Matis LA. PMID: 8459203.
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    397. Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat-->B6 mouse). Transplant Proc. 1993 Feb; 25(1 Pt 1):438-9. Zeng Y, Bluestone JA, Ildstad ST, Torres MA, Montag AG, Thistlethwaite RJ. PMID: 8438368.
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    398. Immunosuppressive effects of anti-CD3 MAb and soluble co-stimulatory molecules. Transplant Proc. 1993 Feb; 25(1 Pt 1):546-7. Bluestone JA, Bruce D, Peterson L, Thistlethwaite JR, Josephson M, Zeng Y, Linsley PS, Lenschow DJ. PMID: 8438407.
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    399. Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier. J Immunol. 1993 Jan 01; 150(1):265-77. Blazar BR, Taylor PA, Snover DC, Bluestone JA, Vallera DA. PMID: 8417127.
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    400. Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition. J Exp Med. 1992 Dec 01; 176(6):1757-61. Bluestone JA, Jameson S, Miller S, Dick R. PMID: 1460430.
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    401. Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection. J Immunol. 1992 Nov 15; 149(10):3200-7. Sperling AI, Cron RQ, Decker DC, Stern DA, Bluestone JA. PMID: 1431099.
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    402. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol. 1992 Aug 15; 149(4):1124-30. Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. PMID: 1380032.
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    403. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science. 1992 Aug 07; 257(5071):789-92. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA. PMID: 1323143.
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    404. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8. Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA. PMID: 1534096.
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    405. Effects of anti-CD3 monoclonal antibody on engraftment of T-cell-depleted bone marrow allografts in mice: host T-cell suppression, growth factors, and space. Blood. 1992 Jun 01; 79(11):3050-8. Hiruma K, Hirsch R, Patchen M, Bluestone JA, Gress RE. PMID: 1534027.
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    406. Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression. J Immunol. 1992 May 01; 148(9):2756-63. Woodle ES, Thistlethwaite JR, Jolliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA. PMID: 1533410.
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    407. In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors. J Immunol. 1992 Apr 15; 148(8):2363-9. Sandor M, Houlden B, Bluestone J, Hedrick SM, Weinstock J, Lynch RG. PMID: 1532812.
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    408. The T cell receptor in autoimmune diseases. J Rheumatol Suppl. 1992 Apr; 33:75-7. Bluestone JA, Spencer C, Hirsch R. PMID: 1534379.
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    409. Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody. Diabetes. 1992 Mar; 41(3):385-91. Herold KC, Bluestone JA, Montag AG, Parihar A, Wiegner A, Gress RE, Hirsch R. PMID: 1532369.
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    410. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. J Exp Med. 1992 Mar 01; 175(3):695-707. Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. PMID: 1531495.
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    411. A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I. J Immunol. 1992 Feb 15; 148(4):983-8. Johnson RM, Lancki DW, Sperling AI, Dick RF, Spear PG, Fitch FW, Bluestone JA. PMID: 1310711.
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    412. A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J Exp Med. 1992 Jan 01; 175(1):49-56. Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, Bluestone JA, Nomoto K. PMID: 1530961.
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    413. Activation of T cells in vivo using anti-CD3 and staphylococcal enterotoxins. Int J Cancer Suppl. 1992; 7:39-41. Bluestone JA, Bruce DS, Newell KA. PMID: 1428401.
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    414. Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue. J Exp Med. 1992 Jan 01; 175(1):65-70. Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick SM, Bluestone JA. PMID: 1730927.
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    415. Immunopotentiation of anti-viral and anti-tumor immune responses using anti-T cell receptor antibodies and mitogens. Ann N Y Acad Sci. 1991 Dec 30; 636:279-87. Newell KA, Ellenhorn JD, Hirsch R, Bluestone JA. PMID: 1793214.
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    416. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991 Dec 01; 147(11):3736-44. Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, Kiyono H. PMID: 1682383.
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    417. Inter-mouse strain differences in the in vivo anti-CD3 induced cytokine release. Clin Exp Immunol. 1991 Dec; 86(3):537-43. Ferran C, Dy M, Sheehan K, Merite S, Schreiber R, Landais P, Grau G, Bluestone J, Bach JF, Chatenoud L. PMID: 1721015.
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    418. CD4-CD8- thymocytes from MRL-lpr/lpr mice exhibit abnormal proportions of alpha beta- and gamma delta-TCR+ cells and demonstrate defective responsiveness when activated through the TCR. Cell Immunol. 1991 Oct 15; 137(2):269-82. Kakkanaiah VN, Nagarkatti M, Bluestone JA, Nagarkatti PS. PMID: 1832583.
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    427. Junctional sequences influence the specificity of gamma/delta T cell receptors. J Exp Med. 1991 Feb 01; 173(2):503-6. Rellahan BL, Bluestone JA, Houlden BA, Cotterman MM, Matis LA. PMID: 1703211.
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    428. In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):1074-8. Newell KA, Ellenhorn JD, Bruce DS, Bluestone JA. PMID: 1899481.
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    436. Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells. J Immunol. 1990 Oct 01; 145(7):2254-9. Kast WM, Bluestone JA, Heemskerk MH, Spaargaren J, Voordouw AC, Ellenhorn JD, Melief CJ. PMID: 2168920.
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    437. Activation of human T cells in vivo following treatment of transplant recipients with OKT3. Transplantation. 1990 Oct; 50(4):608-12. Ellenhorn JD, Woodle ES, Ghobreal I, Thistlethwaite JR, Bluestone JA. PMID: 2145669.
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    438. Reduction of morbidity and cytokine release in anti-CD3 MoAb-treated mice by corticosteroids. Transplantation. 1990 Oct; 50(4):642-8. Ferran C, Dy M, Merite S, Sheehan K, Schreiber R, Leboulenger F, Landais P, Bluestone J, Bach JF, Chatenoud L. PMID: 1699310.
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    440. Structural basis of Kbm8 alloreactivity. Amino acid substitutions on the beta-pleated floor of the antigen recognition site. J Immunol. 1990 Sep 01; 145(5):1456-62. Hunt HD, Pullen JK, Dick RF, Bluestone JA, Pease LR. PMID: 2384667.
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    441. Neurotoxicity after treatment with muromonab-CD3. N Engl J Med. 1990 Aug 16; 323(7):487-8. Richards JM, Vogelzang NJ, Bluestone JA. PMID: 2115619.
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    444. Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb. Transplantation. 1990 Jun; 49(6):1117-23. Hirsch R, Bluestone JA, DeNenno L, Gress RE. PMID: 2141740.
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    447. Self-reactive gamma delta T cells are eliminated in the thymus. Nature. 1990 Feb 22; 343(6260):714-9. Dent AL, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick SM. PMID: 1968227.
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    448. Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 09; 60(3):451-9. Grusby MJ, Nabavi N, Wong H, Dick RF, Bluestone JA, Schotz MC, Glimcher LH. PMID: 2302735.
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    449. Polymorphisms and diversity of T-cell receptor-gamma proteins expressed in mouse spleen. Immunogenetics. 1990; 31(4):220-8. Cron RQ, Coligan JE, Bluestone JA. PMID: 2329007.
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    451. Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer. Science. 1989 Aug 18; 245(4919):746-9. Matis LA, Fry AM, Cron RQ, Cotterman MM, Dick RF, Bluestone JA. PMID: 2528206.
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    452. Anti-CD3 antibody for autoimmune disease, a cautionary note. Lancet. 1989 Jun 17; 1(8651):1390. Hirsch R, Gress RE, Bluestone JA. PMID: 2567402.
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    453. Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells. J Immunol. 1989 Jun 01; 142(11):3754-62. Cron RQ, Gajewski TF, Sharrow SO, Fitch FW, Matis LA, Bluestone JA. PMID: 2523934.
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    454. Suppression of the humoral response to anti-CD3 monoclonal antibody. Transplantation. 1989 May; 47(5):853-7. Hirsch R, Chatenoud L, Gress RE, Sachs DH, Bach JF, Bluestone JA. PMID: 2524123.
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