Jeffrey Bluestone, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Phone415-514-0417
ORCID ORCID Icon0000-0001-8793-7848 Additional info
vCardDownload vCard
    Other Positions
    Title(s)Professor, School of Medicine


    Collapse Biography 
    Collapse Education and Training
    Cornell Graduate School of Medical SciencePh.D.1980Immunology
    Rutgers - State UniversityM.S1977Microbiology
    Cook College, Rutgers UniversityB.S.1974Biology
    Collapse Awards and Honors
    Gould Foundation 1987  - 1989Faculty Scholar
    American Cancer Society1989Faculty Scholar
    Guggenheim Foundation1997Senior Fellowship
    Fogarty Foundation1997Senior Research Fellowship
    Cornell Medical School1998Distinguished Alumni Award
    Juvenile Diabetes Research Foundation2004Gerold & Kayla Grodsky Basic Science Award
    American Society for Transplantation2004Roche Distinguished Research Award
    Juvenile Diabetes Research Foundation2005Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award
    American Academy of Arts and Sciences2006Elected Member
    Juvenile Diabetes Research Foundation2008Scholar Award
    American Academy of Allergy, Asthma, & Immunology2010Elliott Middleton Memorial Lectureship
    National Academy of Medicine2013Elected Member
    American Society of Transplantation2015Outstanding Mentorship Award
    Federation of Clinical Immunology Societies2015President-Elect
    National Cancer Foundation2016Blue Ribbon Panel on Cancer Research (Biden Moonshot Program)

    Collapse Overview 
    Collapse Overview
    Jeffrey Bluestone, PhD, is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology and is the Director of the Hormone Research Institute in the Diabetes Center. His research over the past 25 years has focused on understanding the basic processes that control T cell activation and immune tolerance in autoimmunity and organ transplantation. He and members of his lab have developed soluble receptor antagonists; monoclonal antibodies and animals deficient in individual members of TCR and co-stimulatory pathways to define their individual roles in transplant rejection and autoimmunity including a special emphasis on a specialized subset of T cells termed “regulatory T cells” (Treg). Tregs control fundamental aspect of immune homeostasis. During the last several years, his research has adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity and under conditions of allotransplant rejection. Moreover, a strong role for antigen-specific Tregs have been found in these model systems and further evidence in humanized mice and transplant patients that alloantigen-specific Tregs are more effective. Thus, the major goal of this work is to identify the antigen-specificity of thymic- and peripherally-derived Tregs with the expectation that these TCRs can be adapted for immunotherapy. Finally, his lab initiated several projects to determine mechanisms that control Treg stability. The goal is to develop approaches using pharmacogenomics to either stabilize or destabilize Tregs in autoimmunity and cancer.

    In March 2010 Dr. Bluestone was appointed executive vice chancellor and provost at the University of California San Francisco (UCSF) serving as chief academic officer guiding the research and academic enterprise advancing the campus priorities in close collaboration with the chancellor and the campus leadership teams, and to oversee the campus ethics and compliance enterprise. Previously he served in a number of posts including Director of theUCSF Diabetes Center, as Director of the Immune Tolerance Network.

    In June 2008 Dr. Bluestone served as interim vice chancellor of research; directing the advancement of cross-campus research initiatives, such as enhancing core research facilities. In this capacity, he played a leading role in coordinating and integrating current research cores. He worked also to strengthen external research partnerships, particularly with industry, and focused on facilitating the translation of UCSF discoveries into public benefit.

    In 2009, Dr. Bluestone led the UCSF committee to strategize and secure funds available through the American Recovery and Reinvestment Act, making the campus one of the top institutional recipients in the nation of science-based stimulus funds.

    Dr. Bluestone joined the UCSF faculty in 2000. He is an international leader in the field of immunotherapy, with a stellar record of scholarly achievement and a decade of significant contributions to the research enterprise at UCSF, including the creation and directorship of an integrated UCSF Diabetes Center to focus on translating basic research in both type 1 and type 2 diabetes into improved therapies for patients. He also founded and directed the Immune Tolerance Network, a consortium of more than 1,000 of the world’s leading scientific researchers and clinical specialists from nearly 50 institutions, with the mission of testing new therapies to promote immune tolerance in transplantation, autoimmune diseases, asthma and allergic diseases.

    As a research scientist, Dr. Bluestone has helped clarify the body’s immune response on a molecular level. His systematic investigation has catalyzed recent progress in stem cell research, islet cell transplantation and immune tolerance therapies – experimentation that has formidably translated into drugs to treat human disease.

    Through his 30-year scientific career, he has authored more than 300 peer-reviewed publications that include prominent papers in Nature, Nature Immunology, and the Journal of Immunology and Diabetes. He has received numerous accolades for his work, including his 2006 election to the American Academy of Arts and Sciences, the Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation, and the distinguished alumni award from the Cornell Graduate School of Medical Science.

    Prior to joining UCSF, Bluestone was at the University of Chicago, where he was a member of the Ben May Institute for Cancer Research, rising over 13 years from an associate professor to the director of the institute. He had previously worked for seven years in various roles at the National Cancer Institute of the National Institutes of Health, ultimately becoming a senior investigator in the Immunology Branch of the National Cancer Institute.

    Dr. Bluestone earned both his BS in biology and his MS in microbiology from Rutgers State University, and his PhD in immunology from the Cornell Graduate School of Medical Science (Sloan-Kettering Division).
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Designer Tregs for restoring tolerance in patients with type 1 diabetes
    NIH UC4DK116264Sep 20, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH U01DK107383Jul 1, 2016 - Dec 31, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK R01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Co-Principal Investigator
    Disruption of T cell tolerance in type 1 diabetes
    NIH P01AI118688Jun 8, 2016 - May 31, 2021
    Role: Co-Investigator
    Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation
    NIH U01AI110658Jun 1, 2014 - May 31, 2021
    Role: Co-Principal Investigator
    Autoimmunity Center of Excellence Clinical Research Program
    NIH UM1AI110498May 1, 2014 - Apr 30, 2020
    Role: Co-Investigator
    Role of Innate Lymphoid Cells in Autoimmunity
    NIH R21AI107328Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    Donor-Specific Regulatory T Cell Therapy in Liver Transplantation
    NIH R34AI095135Apr 1, 2012 - Mar 31, 2014
    Role: Co-Principal Investigator
    Expanding beta-cell mass
    NIH U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Role of Notch 1 in Immune Tolerance
    NIH R21AI059979Apr 1, 2004 - Mar 31, 2007
    Role: Principal Investigator
    Autoimmunity Center of Excellence
    NIH U19AI056388Sep 30, 2003 - Apr 30, 2015
    Role: Co-Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Principal Investigator
    Conf on Mechanism and Applications of Immune Tolerance
    NIH R13AI051294Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    Spontaneous Autoimmune Model of Peripheral Neuropathy
    NIH R01AI050834Dec 15, 2001 - Nov 30, 2012
    Role: Principal Investigator
    Immune tolerance network: lung transplantation
    NIH N01AI15416-20-0-10Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: liver transplantation
    NIH N01AI15416-20-0-11Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Systemic lupus rythematosus (SLE)
    NIH N01AI15416-20-0-12Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Kidney, Liver and Bone Marrow Transplantation
    NIH N01AI15416-20-0-2Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Food Allergy
    NIH N01AI15416-20-0-3Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Type 1 diabetes
    NIH N01AI15416-20-0-4Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Multiple sclerosis
    NIH N01AI15416-20-0-5Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Rheumatoid arthritis
    NIH N01AI15416-20-0-6Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Autoimmune diseases: Vasculitis
    NIH N01AI15416-20-0-7Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Islet cell transplantation
    NIH N01AI15416-20-0-8Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: heart tranplantation
    NIH N01AI15416-20-0-9Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: liver transplantation
    NIH N01AI15416-23-0-11Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Systemic lupus rythematosus (SLE)
    NIH N01AI15416-23-0-12Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: kidney transplantation
    NIH N01AI15416-23-0-13Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    IImmune Tolerance Network: Airborne Allergens and Allergic Rhintitis
    NIH N01AI15416-23-0-14Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Food Allergy
    NIH N01AI15416-23-0-3Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Type 1 diabetes
    NIH N01AI15416-23-0-4Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Multiple sclerosis
    NIH N01AI15416-23-0-5Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    FASEB SUMMER CONFERENCE--LYMPHOCYTES AND ANTIBODIES
    NIH R13AI047114Jun 1, 2000 - May 31, 2001
    Role: Principal Investigator
    Immunomodulation of transplant rejection by Anti-CD3 mAb
    NIH R01AI046643Mar 1, 2000 - Nov 30, 2016
    Role: Principal Investigator
    IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB
    NIH R37AI046643Mar 1, 2000 - Feb 28, 2011
    Role: Principal Investigator
    MOFLO MULTILASER FLOW CYTOMETER
    NIH S10RR014884Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    COLLABORATIVE NETWORK FOR CLINICAL RES ON IMMUNE TOLERAN
    NIH/NIAID N01AI095380Sep 30, 1999 - Sep 29, 2006
    Role: Principal Investigator
    TOLERANCE OF ISLET CELL GRAFT
    NIH R01DK055351Jun 15, 1999 - May 31, 2003
    Role: Principal Investigator
    CTLA 4 ANTAGONISM DURING T CELL ACTIVATION
    NIH F33AI009895Mar 22, 1998
    Role: Principal Investigator
    Immune Tolerance and Autoimmunity
    NIH P01AI035297Sep 1, 1997 - Jul 31, 2012
    Role: Co-Investigator
    SCOR in Cellular and Molecular Mechanisms of Asthma
    NIH P50HL056399Sep 30, 1996 - Aug 31, 2006
    Role: Co-Principal Investigator
    IMMUNOREGULATION OF IDDM
    NIH P01DK049799Jun 15, 1995 - May 31, 2000
    Role: Co-Investigator
    COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    NIH P01AI035294Sep 1, 1993 - Aug 31, 2001
    Role: Principal Investigator
    IMMUNOMODULATION OF TRANSPLANT REJECTION
    NIH P01AI029531Jun 1, 1990 - Aug 31, 2000
    Role: Principal Investigator
    IMMUNOBIOLOGY OF TCR GAMMA/DELTA T-CELLS
    NIH R01AI026847Sep 1, 1988 - Aug 31, 1999
    Role: Principal Investigator
    IN VIVO POTENTIATION OF IMMUNE RESPONSES
    NIH R01CA049260Aug 5, 1988 - Jul 31, 1995
    Role: Principal Investigator
    Interdisciplinary Training Program in Immunology
    NIH T32AI007090Jul 1, 1979 - Jun 30, 2024
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA014599Feb 1, 1977 - Mar 31, 2018
    Role: Co-Investigator
    IMMUNITY AND CANCER
    NIH P01CA019266Jun 1, 1976 - Mar 31, 1996
    Role: Co-Investigator
    Immune Tolerance Network: Autoimmune Diseases
    NIH/NIAID N01AI15416
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes. JCI Insight. 2021 Sep 22; 6(18). Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. PMID: 34324441.
      View in: PubMed   Mentions:    Fields:    
    2. Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR. J Immunother Cancer. 2021 Sep; 9(9). Bayless NL, Bluestone JA, Bucktrout S, Butterfield LH, Jaffee EM, Koch CA, Roep BO, Sharpe AH, Murphy WJ, Villani AC, Walunas TL. PMID: 34479924.
      View in: PubMed   Mentions:    Fields:    
    3. Immunotherapy: Building a bridge to a cure for type 1 diabetes. Science. 2021 Jul 30; 373(6554):510-516. Bluestone JA, Buckner JH, Herold KC. PMID: 34326232.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2021 08; 9(8):502-514. Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, Wentworth JM, Willi SM, Krischer JP, Bluestone JA, Gleevec Trial Study Group . PMID: 34214479.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    5. The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Front Immunol. 2021; 12:639818. Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q. PMID: 33833759.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines. Trends Immunol. 2021 04; 42(4):293-311. Kang JH, Bluestone JA, Young A. PMID: 33714688.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity. Cancer Discov. 2021 03; 11(3):537-539. Young A, Bluestone JA. PMID: 33653918.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19. Cell. 2020 12 10; 183(6):1479-1495.e20. Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai CL, Voillet V, Duvvuri VR, Scherler K, Troisch P, Baloni P, Qin G, Smith B, Kornilov SA, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Heath JE, Earls J, Zhang R, Xie J, Li S, Roper R, Jones L, Zhou Y, Rowen L, Liu R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Zager MA, ISB-Swedish COVID19 Biobanking Unit , Wei W, Price ND, Huang S, Subramanian N, Wang K, Magis AT, Hadlock JJ, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg PD, Gottardo R, Davis MM, Goldman JD, Heath JR. PMID: 33171100.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCTClinical Trials
    9. Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis. Sci Immunol. 2020 10 02; 5(52). Lee JC, Mehdizadeh S, Smith J, Young A, Mufazalov IA, Mowery CT, Daud A, Bluestone JA. PMID: 33008914.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    10. Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes. Cell Stem Cell. 2020 10 01; 27(4):505-507. Bluestone JA, Tang Q. PMID: 33007232.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nat Immunol. 2020 11; 21(11):1456-1466. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. PMID: 32989329.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Tolerance in the Age of Immunotherapy. N Engl J Med. 2020 09 17; 383(12):1156-1166. Bluestone JA, Anderson M. PMID: 32937048.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories. bioRxiv. 2020 Jul 31. Su Y, Chen D, Lausted C, Yuan D, Choi J, Dai C, Voillet V, Scherler K, Troisch P, Duvvuri VR, Baloni P, Qin G, Smith B, Kornilov S, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Jones L, Zhou Y, Roper R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Michael ZA, Magis A, Wei W, Price ND, Huang S, Subramanian N, Wang K, Hadlock J, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg P, Gottardo R, Davis MM, Goldman JD, Heath JR. PMID: 32766585.
      View in: PubMed   Mentions:
    14. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet. 2020 05 23; 395(10237):1627-1639. Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, Juerchott K, Braudeau C, James B, Contreras-Ruiz L, van der Net JB, Bergler T, Caldara R, Petchey W, Edinger M, Dupas N, Kapinsky M, Mutzbauer I, Otto NM, Öllinger R, Hernandez-Fuentes MP, Issa F, Ahrens N, Meyenberg C, Karitzky S, Kunzendorf U, Knechtle SJ, Grinyó J, Morris PJ, Brent L, Bushell A, Turka LA, Bluestone JA, Lechler RI, Schlitt HJ, Cuturi MC, Schlickeiser S, Friend PJ, Miloud T, Scheffold A, Secchi A, Crisalli K, Kang SM, Hilton R, Banas B, Blancho G, Volk HD, Lombardi G, Wood KJ, Geissler EK. PMID: 32446407.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    15. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. 2020 06; 582(7812):416-420. Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, Prator GY, Zhang B, Lee Y, Sun Z, Ifergan I, Van Gool F, Hargreaves DC, Bluestone JA, Marson A, Fang D. PMID: 32499641.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    16. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    17. Accelerating the development of innovative cellular therapy products for the treatment of cancer. Cytotherapy. 2020 05; 22(5):239-246. Stewart MD, Keane A, Butterfield LH, Levine BL, Thompson B, Xu Y, Ramsborg C, Lee A, Kalos M, Koerner C, Moore T, Markovic I, Lasiter L, Ibrahim R, Bluestone J, Sigal E, Allen J. PMID: 32199724.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression. J Immunol. 2020 02 15; 204(4):747-751. Mufazalov IA, Andruszewski D, Schelmbauer C, Heink S, Blanfeld M, Masri J, Tang Y, Schüler R, Eich C, Wunderlich FT, Karbach SH, Bluestone JA, Korn T, Waisman A. PMID: 31924653.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. New Frontiers in the Treatment of Type 1 Diabetes. Cell Metab. 2020 01 07; 31(1):46-61. Warshauer JT, Bluestone JA, Anderson MS. PMID: 31839487.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat Biotechnol. 2020 01; 38(1):44-49. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. PMID: 31819258.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    21. Treg cell-based therapies: challenges and perspectives. Nat Rev Immunol. 2020 03; 20(3):158-172. Raffin C, Vo LT, Bluestone JA. PMID: 31811270.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    22. Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model. PLoS One. 2019; 14(10):e0217728. Holohan DR, Van Gool F, Bluestone JA. PMID: 31647813.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Next-generation regulatory T cell therapy. Nat Rev Drug Discov. 2019 10; 18(10):749-769. Ferreira LMR, Muller YD, Bluestone JA, Tang Q. PMID: 31541224.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    24. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 08 15; 381(7):603-613. Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ, Type 1 Diabetes TrialNet Study Group . PMID: 31180194.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCellsCTClinical Trials
    25. NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87. Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity. 2019 02 19; 50(2):362-377.e6. Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. PMID: 30709738.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 03; 71(3):431-440. Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandova PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, Rosenblum MD, Autoimmunity Centers of Excellence . PMID: 30277008.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    28. Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer. Front Med (Lausanne). 2018; 5:351. Bridge JA, Lee JC, Daud A, Wells JW, Bluestone JA. PMID: 30631766.
      View in: PubMed   Mentions:
    29. The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy. Cancer Immunol Res. 2018 12; 6(12):1445-1452. Young A, Quandt Z, Bluestone JA. PMID: 30510057.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    30. Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again. Genome Med. 2018 10 31; 10(1):79. Bucktrout SL, Bluestone JA, Ramsdell F. PMID: 30376867.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier. J Allergy Clin Immunol. 2018 12; 142(6):1710-1718. Esensten JH, Muller YD, Bluestone JA, Tang Q. PMID: 30367909.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    32. Treg cells-the next frontier of cell therapy. Science. 2018 10 12; 362(6411):154-155. Bluestone JA, Tang Q. PMID: 30309932.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    33. Chance favours the prepared mind. Nat Rev Immunol. 2018 09; 18(9):541. Bluestone JA. PMID: 30018454.
      View in: PubMed   Mentions:    Fields:    
    34. Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. J Immunol. 2018 10 01; 201(7):2094-2106. Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC. PMID: 30104245.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    35. Revisiting IL-2: Biology and therapeutic prospects. Sci Immunol. 2018 07 06; 3(25). Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA. PMID: 29980618.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    36. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2018 07; 559(7715):E13. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 29899441.
      View in: PubMed   Mentions:    Fields:    
    37. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018 07; 24(7):1005-1014. Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA. PMID: 29942088.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    38. Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors. Diabetes. 2018 08; 67(8):1471-1480. Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC. PMID: 29937434.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimals
    39. Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. Cell Rep. 2018 06 12; 23(11):3262-3274. Wang D, Quiros J, Mahuron K, Pai CC, Ranzani V, Young A, Silveria S, Harwin T, Abnousian A, Pagani M, Rosenblum MD, Van Gool F, Fong L, Bluestone JA, DuPage M. PMID: 29898397.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    40. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    41. Pathological conversion of regulatory T cells is associated with loss of allotolerance. Sci Rep. 2018 05 04; 8(1):7059. Hua J, Inomata T, Chen Y, Foulsham W, Stevenson W, Shiang T, Bluestone JA, Dana R. PMID: 29728574.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    42. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Proc Natl Acad Sci U S A. 2018 05 15; 115(20):5265-5270. Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q. PMID: 29712852.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    43. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018 03 02; 359(6379):1037-1042. Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. PMID: 29496879.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    44. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2017; 8:1844. Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Golab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grzes D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. PMID: 29379498.
      View in: PubMed   Mentions: 13     Fields:    
    45. Future cancer research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 11; 18(11):e653-e706. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. PMID: 29208398.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    46. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes. Front Immunol. 2017; 8:1313. Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM. PMID: 29123516.
      View in: PubMed   Mentions: 21     Fields:    
    47. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017 09 07; 549(7670):111-115. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 28854172.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    48. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov; 17(11):2945-2954. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. PMID: 28675676.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCellsCTClinical Trials
    49. Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy? Nat Med. 2017 08 04; 23(8):1004. June CH, Warshauer JT, Bluestone JA. PMID: 28777789.
      View in: PubMed   Mentions: 2     Fields:    
    50. Is autoimmunity the Achilles' heel of cancer immunotherapy? Nat Med. 2017 05 05; 23(5):540-547. June CH, Warshauer JT, Bluestone JA. PMID: 28475571.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    51. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; 25(5):1207. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28467938.
      View in: PubMed   Mentions: 10     Fields:    
    52. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28380378.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    53. FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance. J Immunol. 2017 02 01; 198(3):979-980. Bluestone JA. PMID: 28115585.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    54. Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy. Mol Ther Methods Clin Dev. 2017 Mar 17; 4:178-191. Seay HR, Putnam AL, Cserny J, Posgai AL, Rosenau EH, Wingard JR, Girard KF, Kraus M, Lares AP, Brown HL, Brown KS, Balavage KT, Peters LD, Bushdorf AN, Atkinson MA, Bluestone JA, Haller MJ, Brusko TM. PMID: 28345003.
      View in: PubMed   Mentions:
    55. Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. Annu Rev Pathol. 2017 Jan 24; 12:305-330. Esensten JH, Bluestone JA, Lim WA. PMID: 27959633.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    56. CD28 Costimulation: From Mechanism to Therapy. Immunity. 2016 05 17; 44(5):973-88. Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA. PMID: 27192564.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    57. Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016 05 01; 196(9):3966. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF. PMID: 27183651.
      View in: PubMed   Mentions: 1     Fields:    
    58. Regulatory T cell therapy for type 1 diabetes: May the force be with you. J Autoimmun. 2016 07; 71:78-87. Gitelman SE, Bluestone JA. PMID: 27133597.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    59. Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial. Diabetologia. 2016 06; 59(6):1153-61. Gitelman SE, Gottlieb PA, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Harris KM, Kanaparthi S, Phippard D, Ding L, Bluestone JA, Ehlers MR, ITN START Study Team . PMID: 27053235.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    60. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol. 2016 Mar; 16(3):149-63. DuPage M, Bluestone JA. PMID: 26875830.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    61. CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016 Mar 01; 196(5):2051-2062. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF. PMID: 26826243.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    62. Inducing and Administering Tregs to Treat Human Disease. Front Immunol. 2015; 6:654. Perdigoto AL, Chatenoud L, Bluestone JA, Herold KC. PMID: 26834735.
      View in: PubMed   Mentions: 24     Fields:    
    63. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25; 7(315):315ra189. Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. PMID: 26606968.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansCellsCTClinical Trials
    64. Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction. Mol Genet Metab. 2016 Feb; 117(2):66-83. Kishnani PS, Dickson PI, Muldowney L, Lee JJ, Rosenberg A, Abichandani R, Bluestone JA, Burton BK, Dewey M, Freitas A, Gavin D, Griebel D, Hogan M, Holland S, Tanpaiboon P, Turka LA, Utz JJ, Wang YM, Whitley CB, Kazi ZB, Pariser AR. PMID: 26597321.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    65. Shifting the Evolving CAR T Cell Platform into Higher Gear. Cancer Cell. 2015 Oct 12; 28(4):401-402. Holohan DR, Lee JC, Bluestone JA. PMID: 26461084.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    66. Targeting Treg signaling for the treatment of autoimmune diseases. Curr Opin Immunol. 2015 Dec; 37:11-20. Spence A, Klementowicz JE, Bluestone JA, Tang Q. PMID: 26432763.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    67. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10437-42. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. PMID: 26216948.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansCells
    68. Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. PMID: 26092469.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    69. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. J Immunol. 2015 Jul 01; 195(1):145-55. Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM. PMID: 25994968.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    70. IL-2: Change Structure … Change Function. Immunity. 2015 May 19; 42(5):779-81. Bluestone JA, Crellin N, Trotta E. PMID: 25992850.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    71. T cells in the control of organ-specific autoimmunity. J Clin Invest. 2015 Jun; 125(6):2250-60. Bluestone JA, Bour-Jordan H, Cheng M, Anderson M. PMID: 25985270.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    72. The therapeutic potential of regulatory T cells for the treatment of autoimmune disease. Expert Opin Ther Targets. 2015; 19(8):1091-103. Bluestone JA, Trotta E, Xu D. PMID: 25881491.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    73. Immunotherapy: making the case for precision medicine. Sci Transl Med. 2015 Mar 25; 7(280):280ed3. Bluestone JA, Tang Q. PMID: 25810308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    74. The immune system in Duchenne muscular dystrophy: Friend or foe. Rare Dis. 2015; 3(1):e1010966. Villalta SA, Rosenberg AS, Bluestone JA. PMID: 26481612.
      View in: PubMed   Mentions:
    75. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 2015 Feb 17; 42(2):227-238. DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. PMID: 25680271.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    76. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015 Feb; 16(2):188-96. Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. PMID: 25559257.
      View in: PubMed   Mentions: 189     Fields:    Translation:AnimalsCells
    77. Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    78. Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm. Cell Stem Cell. 2015 Feb 05; 16(2):148-57. Szot GL, Yadav M, Lang J, Kroon E, Kerr J, Kadoya K, Brandon EP, Baetge EE, Bour-Jordan H, Bluestone JA. PMID: 25533131.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    79. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 04; 124(24):3572-6. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. PMID: 25323825.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    80. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med. 2014 Oct 15; 6(258):258ra142. Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone JA. PMID: 25320234.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    81. Aberrant innate immune activation following tissue injury impairs pancreatic regeneration. PLoS One. 2014; 9(7):e102125. Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M. PMID: 25010227.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    82. Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function. Eur J Immunol. 2014 Jun; 44(6):1737-46. Stumpf M, Zhou X, Chikuma S, Bluestone JA. PMID: 24648182.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    83. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med. 2014 Jan; 20(1):62-8. Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H. PMID: 24362934.
      View in: PubMed   Mentions: 365     Fields:    Translation:HumansAnimalsCells
    84. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity. 2013 Nov 14; 39(5):949-62. Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA. PMID: 24238343.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    85. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med. 2013 Nov 01; 3(11). Tang Q, Bluestone JA. PMID: 24186492.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    86. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant. 2013 Nov; 13(11):3010-20. Putnam AL, Safinia N, Medvec A, Laszkowska M, Wray M, Mintz MA, Trotta E, Szot GL, Liu W, Lares A, Lee K, Laing A, Lechler RI, Riley JL, Bluestone JA, Lombardi G, Tang Q. PMID: 24102808.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    87. Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2013 Dec; 1(4):306-16. Gitelman SE, Gottlieb PA, Rigby MR, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, Ding L, Bluestone JA, Ehlers MR, START Study Team . PMID: 24622416.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCTClinical Trials
    88. Peripherally induced tregs - role in immune homeostasis and autoimmunity. Front Immunol. 2013; 4:232. Yadav M, Stephan S, Bluestone JA. PMID: 23966994.
      View in: PubMed   Mentions: 90     Fields:    
    89. CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. J Exp Med. 2013 Jul 29; 210(8):1603-19. Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, Lipsky RH, Marini A, Chen J, Mughal M, Mattson MP, Taub DD, Bluestone JA. PMID: 23878307.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    90. Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol. 2013 Jul; 11(7):e1001610. Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA. PMID: 23874157.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    91. microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. J Immunol. 2013 Aug 15; 191(4):1594-605. de Kouchkovsky D, Esensten JH, Rosenthal WL, Morar MM, Bluestone JA, Jeker LT. PMID: 23858035.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    92. Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. J Autoimmun. 2013 Sep; 45:58-67. Bour-Jordan H, Thompson HL, Giampaolo JR, Davini D, Rosenthal W, Bluestone JA. PMID: 23850635.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    93. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes. 2013 Nov; 62(11):3766-74. Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA, AbATE Study Team . PMID: 23835333.
      View in: PubMed   Mentions: 117     Fields:    Translation:Humans
    94. Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes. 2013 Aug; 62(8):2870-8. Villalta SA, Lang J, Kubeck S, Kabre B, Szot GL, Calderon B, Wasserfall C, Atkinson MA, Brekken RA, Pullen N, Arch RH, Bluestone JA. PMID: 23835340.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    95. The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8. Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. PMID: 23812098.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    96. DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS One. 2013; 8(5):e66282. Jeker LT, Zhou X, Blelloch R, Bluestone JA. PMID: 23741528.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    97. MicroRNA regulation of T-cell differentiation and function. Immunol Rev. 2013 May; 253(1):65-81. Jeker LT, Bluestone JA. PMID: 23550639.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    98. Cell-based therapeutics: the next pillar of medicine. Sci Transl Med. 2013 Apr 03; 5(179):179ps7. Fischbach MA, Bluestone JA, Lim WA. PMID: 23552369.
      View in: PubMed   Mentions: 126     Fields:    Translation:Humans
    99. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr; 14(4):307-8. Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. PMID: 23507634.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    100. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol. 2013 Apr; 13(4):243-56. Herold KC, Vignali DA, Cooke A, Bluestone JA. PMID: 23524461.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    101. Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28. J Immunol. 2013 May 01; 190(9):4470-3. Huang C, Martin S, Pfleger C, Du J, Buckner JH, Bluestone JA, Riley JL, Ziegler SF. PMID: 23543754.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    102. Immune therapy and β-cell death in type 1 diabetes. Diabetes. 2013 May; 62(5):1676-80. Lebastchi J, Deng S, Lebastchi AH, Beshar I, Gitelman S, Willi S, Gottlieb P, Akirav EM, Bluestone JA, Herold KC. PMID: 23423576.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    103. The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes. J Immunol. 2013 Feb 01; 190(3):961-9. Stumpf M, Zhou X, Bluestone JA. PMID: 23293354.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    104. Current and future immunomodulation strategies to restore tolerance in autoimmune diseases. Cold Spring Harb Perspect Biol. 2012 Nov 01; 4(11). Bluestone JA, Bour-Jordan H. PMID: 23125012.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    105. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb; 56(2):391-400. Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. PMID: 23086558.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    106. Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients. Transpl Int. 2012 Dec; 25(12):1257-67. Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F. PMID: 22994802.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    107. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012 Sep 24; 209(10):1713-22, S1-19. Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA. PMID: 22966003.
      View in: PubMed   Mentions: 297     Fields:    Translation:AnimalsCells
    108. Single step isolation and activation of primary CD3+ T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers. . 2012 Aug 08; 12(8):4018-24. Kim K, An HJ, Jun SH, Kim TJ, Lim SA, Park G, Na HB, Park YI, Hyeon T, Yee C, Bluestone JA, Kim J, Lee KM. PMID: 22784189.
      View in: PubMed   Mentions:
    109. The future of cancer treatment: will it include immunotherapy? Cancer Cell. 2012 Jul 10; 22(1):7-8. Bluestone JA, Small EJ. PMID: 22789534.
      View in: PubMed   Mentions: 1     Fields:    
    110. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12668-73. Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H. PMID: 22733744.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    111. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes. 2012 Sep; 61(9):2340-8. Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ, Diabetes TrialNet and the Immune Tolerance Network . PMID: 22721971.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    112. MicroRNA 10a marks regulatory T cells. PLoS One. 2012; 7(5):e36684. Jeker LT, Zhou X, Gershberg K, de Kouchkovsky D, Morar MM, Stadthagen G, Lund AH, Bluestone JA. PMID: 22629323.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    113. NK cells are not required for spontaneous autoimmune diabetes in NOD mice. PLoS One. 2012; 7(4):e36011. Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier LL. PMID: 22558306.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    114. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. PMID: 22570807.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    115. Breakdown in peripheral tolerance in type 1 diabetes in mice and humans. Cold Spring Harb Perspect Med. 2012 Mar; 2(3):a007807. Jeker LT, Bour-Jordan H, Bluestone JA. PMID: 22393537.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    116. CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol. 2012 Feb; 4(1):11-21. Tang Q, Bluestone JA, Kang SM. PMID: 22170955.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    117. The yin and yang of interleukin-2-mediated immunotherapy. N Engl J Med. 2011 Dec 01; 365(22):2129-31. Bluestone JA. PMID: 22129258.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    118. A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse. J Immunol. 2011 Nov 15; 187(10):4947-53. Tada A, Shimada A, Yamada T, Oikawa Y, Yamada Y, Okubo Y, Irie J, Bluestone JA, Itoh H. PMID: 21967896.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    119. Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413. J Immunol. 2011 Oct 01; 187(7):3466-74. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. PMID: 21934098.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    120. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol. 2011 Aug 14; 12(9):898-907. Beyer M, Thabet Y, Müller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schönfeld EA, Böttcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL. PMID: 21841785.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    121. Type 1 diabetes immunotherapy: is the glass half empty or half full? Sci Transl Med. 2011 Aug 10; 3(95):95fs1. Herold KC, Bluestone JA. PMID: 21832236.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    122. Control of TH17 cells occurs in the small intestine. Nature. 2011 Jul 17; 475(7357):514-8. Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. PMID: 21765430.
      View in: PubMed   Mentions: 257     Fields:    Translation:AnimalsCells
    123. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011 Aug 15; 187(4):2015-22. Penaranda C, Tang Q, Bluestone JA. PMID: 21742976.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    124. Regulatory T cells: stability revisited. Trends Immunol. 2011 Jul; 32(7):301-6. Bailey-Bucktrout SL, Bluestone JA. PMID: 21620768.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    125. Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol. 2011 Jul 01; 187(1):325-36. Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, Koentgen F, Ridgway WM, Todd JA, Bluestone JA, Peterson LB, Mattner J, Wicker LS. PMID: 21613616.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    126. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family. Immunol Rev. 2011 May; 241(1):180-205. Bour-Jordan H, Esensten JH, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone JA. PMID: 21488898.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    127. Mechanisms of tolerance. Immunol Rev. 2011 May; 241(1):5-19. Bluestone JA. PMID: 21488886.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    128. How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes. 2011 May; 60(5):1370-9. Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ. PMID: 21525508.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    129. Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. J Surg Res. 2011 Jul; 169(1):e69-75. Brennan TV, Tang Q, Liu FC, Hoang V, Bi M, Bluestone JA, Kang SM. PMID: 21571317.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    130. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol. 2011 Apr 01; 186(7):3918-26. McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM. PMID: 21368230.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    131. Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice. J Immunol. 2011 Apr 01; 186(7):3831-5. Nikoopour E, Sandrock C, Huszarik K, Krougly O, Lee-Chan E, Masteller EL, Bluestone JA, Singh B. PMID: 21357258.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    132. Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS One. 2011 Jan 06; 6(1):e15868. Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL. PMID: 21253593.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    133. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation. 2010 Dec 27; 90(12):1595-601. Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. PMID: 20978464.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    134. Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec; 120(12):4436-44. Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. PMID: 21099117.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    135. The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol. 2010 Nov; 10(11):797-803. Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA. PMID: 20972473.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    136. Clusterin synergizes with IL-2 for the expansion and IFN-γ production of natural killer cells. J Leukoc Biol. 2010 Nov; 88(5):955-63. Sonn CH, Yu YB, Hong YJ, Shim YJ, Bluestone JA, Min BH, Lee KM. PMID: 20729304.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    137. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010 Aug 30; 207(9):1871-8. Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E. PMID: 20679400.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    138. Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia. Curr Opin Organ Transplant. 2010 Aug; 15(4):441-8. Turka LA, Wood K, Bluestone JA. PMID: 20631613.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    139. Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. Am J Transplant. 2010 Aug; 10(8):1870-80. Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. PMID: 20659093.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    140. FK506 causes cellular and functional defects in human natural killer cells. J Leukoc Biol. 2010 Dec; 88(6):1089-97. Kim TJ, Kim N, Kang HJ, Kim EO, Kim ST, Ahn HS, Bluestone JA, Lee KM. PMID: 20671192.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    141. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One. 2010 Jul 22; 5(7):e11726. Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA. PMID: 20668510.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    142. The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse. Clin Exp Immunol. 2010 Aug; 161(2):250-67. Shoda L, Kreuwel H, Gadkar K, Zheng Y, Whiting C, Atkinson M, Bluestone J, Mathis D, Young D, Ramanujan S. PMID: 20491795.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    143. Small RNA regulators of T cell-mediated autoimmunity. J Clin Immunol. 2010 May; 30(3):347-57. Jeker LT, Bluestone JA. PMID: 20393792.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    144. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature. 2010 Apr 29; 464(7293):1293-300. Bluestone JA, Herold K, Eisenbarth G. PMID: 20432533.
      View in: PubMed   Mentions: 382     Fields:    Translation:HumansAnimals
    145. Suppression of human anti-porcine natural killer cell xenogeneic responses by combinations of monoclonal antibodies specific to CD2 and NKG2D and extracellular signal-regulated kinase kinase inhibitor. Immunology. 2010 Aug; 130(4):545-55. Kim TJ, Kim N, Kim EO, Choi JR, Bluestone JA, Lee KM. PMID: 20406306.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    146. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes. 2010 Jun; 59(6):1461-8. Penaranda C, Tang Q, Ruddle NH, Bluestone JA. PMID: 20299465.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    147. Ten years of the Immune Tolerance Network: an integrated clinical research organization. Sci Transl Med. 2010 Feb 17; 2(19):19cm7. Bluestone JA, Krensky AM, Turka LA, Rotrosen D, Matthews JB. PMID: 20371484.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    148. Regulatory T cells directed to the site of the action. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20553-4. Brusko TM, Bluestone JA. PMID: 19955436.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    149. Autoimmunity. Curr Opin Immunol. 2009 Dec; 21(6):579-81. Bluestone JA, Kuchroo V. PMID: 19879742.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    150. Is antigen specificity of autoreactive T cells the key to islet entry? Immunity. 2009 Oct 16; 31(4):534-6. Penaranda C, Bluestone JA. PMID: 19833083.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    151. The functional plasticity of T cell subsets. Nat Rev Immunol. 2009 11; 9(11):811-6. Bluestone JA, Mackay CR, O'Shea JJ, Stockinger B. PMID: 19809471.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    152. How suppressor cells led to anergy, costimulation, and beyond. J Immunol. 2009 Oct 01; 183(7):4147-9. Bour-Jordan H, Bluestone JA. PMID: 19767564.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    153. Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol. 2009 Oct; 5(10):560-5. Esensten JH, Wofsy D, Bluestone JA. PMID: 19798031.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    154. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. PMID: 19783989.
      View in: PubMed   Mentions: 307     Fields:    Translation:AnimalsCells
    155. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009 Sep; 10(9):1000-7. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA. PMID: 19633673.
      View in: PubMed   Mentions: 594     Fields:    Translation:AnimalsCells
    156. Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology. 2009 Oct; 150(10):4531-40. Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF. PMID: 19574401.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    157. Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome. J Immunol. 2009 Jul 15; 183(2):953-61. Perruche S, Zhang P, Maruyama T, Bluestone JA, Saas P, Chen W. PMID: 19561097.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    158. T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. J Immunol. 2009 Jul 01; 183(1):75-82. Esensten JH, Lee MR, Glimcher LH, Bluestone JA. PMID: 19535634.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    159. Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis. Gut. 2009 Oct; 58(10):1363-73. Coquerelle C, Oldenhove G, Acolty V, Denoeud J, Vansanten G, Verdebout JM, Mellor A, Bluestone JA, Moser M. PMID: 19505881.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    160. Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol. 2009 Jun; 21(3):281-5. Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA. PMID: 19500966.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    161. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin Immunol. 2009 Aug; 132(2):166-73. Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA, Immune Tolerance Network ITN007AI Study Group . PMID: 19443276.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    162. Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev. 2009 May; 229(1):41-66. Bour-Jordan H, Bluestone JA. PMID: 19426214.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    163. A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. J Exp Med. 2009 Mar 16; 206(3):507-14. Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA. PMID: 19221395.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    164. The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients. Clin Immunol. 2009 Apr; 131(1):139-44. Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS. PMID: 19150256.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    165. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes. 2009 Mar; 58(3):652-62. Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA. PMID: 19074986.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansCells
    166. Immunoregulatory pathways controlling progression of autoimmunity in NOD mice. Ann N Y Acad Sci. 2008 Dec; 1150:300-10. You S, Alyanakian MA, Segovia B, Damotte D, Bluestone J, Bach JF, Chatenoud L. PMID: 19120317.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    167. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18895-900. Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. PMID: 19015530.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    168. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant. 2008 Oct; 8(10):2086-96. Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, Vincenti F. PMID: 18828769.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCellsCTClinical Trials
    169. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 2008 Oct 23; 455(7216):1109-13. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV. PMID: 18806780.
      View in: PubMed   Mentions: 793     Fields:    Translation:AnimalsCells
    170. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008 Sep 01; 205(9):1983-91. Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. PMID: 18725525.
      View in: PubMed   Mentions: 255     Fields:    Translation:AnimalsCells
    171. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol. 2008 Nov; 28(6):677-84. Bluestone JA, Tang Q, Sedwick CE. PMID: 18716861.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    172. Targeting CD22 reprograms B-cells and reverses autoimmune diabetes. Diabetes. 2008 Nov; 57(11):3013-24. Fiorina P, Vergani A, Dada S, Jurewicz M, Wong M, Law K, Wu E, Tian Z, Abdi R, Guleria I, Rodig S, Dunussi-Joannopoulos K, Bluestone J, Sayegh MH. PMID: 18689692.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    173. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev. 2008 Aug; 224:166-82. Fife BT, Bluestone JA. PMID: 18759926.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansAnimalsCells
    174. Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. J Immunol. 2008 Jun 15; 180(12):7793-803. Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA. PMID: 18523243.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    175. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev. 2008 Jun; 223:371-90. Brusko TM, Putnam AL, Bluestone JA. PMID: 18613848.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    176. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity. 2008 May; 28(5):687-97. Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA. PMID: 18468463.
      View in: PubMed   Mentions: 358     Fields:    Translation:AnimalsCells
    177. CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat Med. 2008 May; 14(5):528-35. Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W. PMID: 18438416.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    178. Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation. Eur J Immunol. 2008 Apr; 38(4):931-4. Brusko T, Bluestone J. PMID: 18395864.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    179. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 2008 Mar; 9(3):239-44. Tang Q, Bluestone JA. PMID: 18285775.
      View in: PubMed   Mentions: 395     Fields:    Translation:HumansAnimalsCells
    180. Safer, longer-lasting regulatory T cells with beta-catenin. Nat Med. 2008 Feb; 14(2):118-9. Bluestone JA, Hebrok M. PMID: 18256611.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    181. Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes. 2008 Apr; 57(4):958-66. Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, Hebrok M. PMID: 18083786.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    182. B cell depletion: a novel therapy for autoimmune diabetes? J Clin Invest. 2007 Dec; 117(12):3642-5. Bour-Jordan H, Bluestone JA. PMID: 18060022.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    183. Transplantation of pancreatic islets into the kidney capsule of diabetic mice. J Vis Exp. 2007; (9):404. Szot GL, Koudria P, Bluestone JA. PMID: 18989445.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    184. Murine pancreatic islet isolation. J Vis Exp. 2007; (7):255. Szot GL, Koudria P, Bluestone JA. PMID: 18989427.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    185. Regulatory T cells: therapeutic potential for treating transplant rejection and type I diabetes. J Vis Exp. 2007; (7):257. Bluestone JA. PMID: 18989429.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    186. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. PMID: 17694047.
      View in: PubMed   Mentions: 251     Fields:    Translation:AnimalsCells
    187. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 2007 Nov; 148(11):5136-44. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC. PMID: 17673522.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    188. What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol. 2007 08; 7(8):650-4. Bluestone JA, Thomson AW, Shevach EM, Weiner HL. PMID: 17653127.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    189. CD3-specific antibodies: a portal to the treatment of autoimmunity. Nat Rev Immunol. 2007 Aug; 7(8):622-32. Chatenoud L, Bluestone JA. PMID: 17641665.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    190. Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J Immunol. 2007 Jul 15; 179(2):1004-12. Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, Bluestone JA. PMID: 17617592.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    191. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol. 2007 Oct; 125(1):16-25. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. PMID: 17627890.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    192. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant. 2007 Jun; 7(6):1457-63. Kang SM, Tang Q, Bluestone JA. PMID: 17511675.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    193. Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. Eur J Immunol. 2007 May; 37(5):1285-9. Chikuma S, Bluestone JA. PMID: 17429849.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    194. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6335-40. You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L. PMID: 17389382.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    195. New reagents on the horizon for immune tolerance. Annu Rev Med. 2007; 58:329-46. St Clair EW, Turka LA, Saxon A, Matthews JB, Sayegh MH, Eisenbarth GS, Bluestone J. PMID: 16987079.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansPHPublic Health
    196. Sensory neurons link the nervous system and autoimmune diabetes. Cell. 2006 Dec 15; 127(6):1097-9. Bour-Jordan H, Bluestone JA. PMID: 17174888.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    197. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med. 2006 Nov 27; 203(12):2737-47. Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA. PMID: 17116737.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    198. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006 Sep 28; 355(13):1318-30. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR. PMID: 17005949.
      View in: PubMed   Mentions: 584     Fields:    Translation:HumansCTClinical Trials
    199. Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes. 2006 Sep; 55(9):2588-94. Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC. PMID: 16936208.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    200. Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev. 2006 Aug; 212:217-37. Tang Q, Bluestone JA. PMID: 16903917.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    201. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006 Aug 01; 177(3):1451-9. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. PMID: 16849451.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    202. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006 Aug; 116(8):2252-61. Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. PMID: 16886063.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    203. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006 Jul 10; 203(7):1701-11. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA. PMID: 16818678.
      View in: PubMed   Mentions: 913     Fields:    Translation:HumansCells
    204. Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship? Nat Immunol. 2006 Jun; 7(6):551-3. Tang Q, Bluestone JA. PMID: 16715063.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    205. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest. 2006 May; 116(5):1371-81. Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M. PMID: 16628253.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    206. CTLA4Ig: bridging the basic immunology with clinical application. Immunity. 2006 Mar; 24(3):233-8. Bluestone JA, St Clair EW, Turka LA. PMID: 16546089.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    207. Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential. Semin Immunol. 2006 Apr; 18(2):103-10. Masteller EL, Tang Q, Bluestone JA. PMID: 16458533.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    208. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. PMID: 16311599.
      View in: PubMed   Mentions: 308     Fields:    Translation:AnimalsCells
    209. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med. 2005 Nov 21; 202(10):1375-86. Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK. PMID: 16287710.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    210. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol. 2005 Nov 01; 175(9):5649-55. Bour-Jordan H, Thompson HL, Bluestone JA. PMID: 16237054.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    211. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol. 2005 Dec; 17(6):638-42. Bluestone JA, Tang Q. PMID: 16209918.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    212. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest. 2005 Oct; 115(10):2904-13. Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC. PMID: 16167085.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    213. A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas. J Immunol. 2005 Sep 15; 175(6):3621-7. Dai YD, Jensen KP, Lehuen A, Masteller EL, Bluestone JA, Wilson DB, Sercarz EE. PMID: 16148106.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    214. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol. 2005 Sep 01; 175(5):3053-9. Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA. PMID: 16116193.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    215. Achieving antigen-specific tolerance in diabetes: regulating specifically. Int Rev Immunol. 2005 Sep-Dec; 24(5-6):287-305. Chen W, Bluestone JA, Herold KC. PMID: 16318983.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    216. A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity. 2005 Aug; 23(2):115-26. Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, Bluestone JA, Eisenbarth GS, Mathis D, Rossini AA, Campbell SE, Kahn R, Kreuwel HT. PMID: 16111631.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimals
    217. B7-independent inhibition of T cells by CTLA-4. J Immunol. 2005 Jul 01; 175(1):177-81. Chikuma S, Abbas AK, Bluestone JA. PMID: 15972645.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    218. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes. 2005 Jun; 54(6):1763-9. Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA. PMID: 15919798.
      View in: PubMed   Mentions: 220     Fields:    Translation:HumansCTClinical Trials
    219. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. J Immunol. 2005 May 01; 174(9):5298-305. Loser K, Scherer A, Krummen MB, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S. PMID: 15843526.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    220. Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. J Immunol. 2005 Apr 15; 174(8):4525-34. Kohm AP, Williams JS, Bickford AL, McMahon JS, Chatenoud L, Bach JF, Bluestone JA, Miller SD. PMID: 15814673.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    221. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J Immunol. 2005 Apr 15; 174(8):4696-705. Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S. PMID: 15814694.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    222. Regulatory T-cell therapy: is it ready for the clinic? Nat Rev Immunol. 2005 04; 5(4):343-9. Bluestone JA. PMID: 15775994.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    223. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol. 2005 Apr; 115(1):3-9. Earle KE, Tang Q, Zhou X, Liu W, Zhu S, Bonyhadi ML, Bluestone JA. PMID: 15870014.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    224. CTLA-4Ig is finally making it: a personal perspective. Am J Transplant. 2005 Mar; 5(3):423-4. Bluestone JA. PMID: 15707394.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    225. Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus. Rev Diabet Stud. 2004; 1(4):156-64. Boehm BO, Bluestone JA. PMID: 17491700.
      View in: PubMed   Mentions: 2     Fields:    
    226. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol. 2005; 23:447-85. Anderson MS, Bluestone JA. PMID: 15771578.
      View in: PubMed   Mentions: 429     Fields:    Translation:AnimalsCells
    227. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol. 2004 Nov; 34(11):2996-3005. Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA. PMID: 15468055.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    228. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest. 2004 Oct; 114(7):979-87. Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA. PMID: 15467837.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    229. Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes. Clin Immunol. 2004 Oct; 113(1):29-37. Judkowski V, Rodriguez E, Pinilla C, Masteller E, Bluestone JA, Sarvetnick N, Wilson DB. PMID: 15380527.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    230. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A. 2004 Oct 05; 101 Suppl 2:14622-6. Bluestone JA, Tang Q. PMID: 15322272.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    231. CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. J Immunol. 2004 Jun 15; 172(12):7442-50. Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD. PMID: 15187122.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    232. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004 Jun 07; 199(11):1455-65. Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA. PMID: 15184499.
      View in: PubMed   Mentions: 414     Fields:    Translation:AnimalsCells
    233. Notch signaling in lymphocyte development and function. Curr Opin Immunol. 2004 Jun; 16(3):360-6. Robey EA, Bluestone JA. PMID: 15134786.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    234. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity. 2004 Jun; 20(6):757-67. Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL. PMID: 15189740.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    235. Notch 1 signaling regulates peripheral T cell activation. Immunity. 2004 Apr; 20(4):407-15. Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. PMID: 15084270.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    236. Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. Am J Transplant. 2004 Mar; 4(3):390-401. Hering BJ, Kandaswamy R, Harmon JV, Ansite JD, Clemmings SM, Sakai T, Paraskevas S, Eckman PM, Sageshima J, Nakano M, Sawada T, Matsumoto I, Zhang HJ, Sutherland DE, Bluestone JA. PMID: 14961992.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    237. Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity. J Immunol. 2004 Feb 01; 172(3):1449-54. Jovasevic VM, Gorelik L, Bluestone JA, Mokyr MB. PMID: 14734721.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    238. Insulin secretion in type 1 diabetes. Diabetes. 2004 Feb; 53(2):426-33. Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC. PMID: 14747294.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCTClinical Trials
    239. Beta-cell replacement for type I diabetes. Annu Rev Med. 2004; 55:133-56. Stock PG, Bluestone JA. PMID: 14746513.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    240. Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. J Immunol. 2003 Nov 15; 171(10):5587-95. Masteller EL, Warner MR, Ferlin W, Judkowski V, Wilson D, Glaichenhaus N, Bluestone JA. PMID: 14607967.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    241. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol. 2003 Oct 01; 171(7):3348-52. Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA. PMID: 14500627.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    242. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med. 2003 Sep; 9(9):1202-8. Belghith M, Bluestone JA, Barriot S, Mégret J, Bach JF, Chatenoud L. PMID: 12937416.
      View in: PubMed   Mentions: 205     Fields:    Translation:AnimalsCells
    243. Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: in vitro characterization and in vivo factors affecting biodistribution. Pharm Res. 2003 Aug; 20(8):1239-48. Park CG, Thiex NW, Lee KM, Szot GL, Bluestone JA, Lee KD. PMID: 12948022.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    244. Clinical trials of transplant tolerance: slow but steady progress. Am J Transplant. 2003 Jul; 3(7):794-803. Matthews JB, Ramos E, Bluestone JA. PMID: 12814471.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    245. Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis. J Clin Invest. 2003 Jun; 111(12):1923-31. Ding W, Beissert S, Deng L, Miranda E, Cassetty C, Seiffert K, Campton KL, Yan Z, Murphy GF, Bluestone JA, Granstein RD. PMID: 12813028.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    246. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003 Mar; 3(3):253-7. Bluestone JA, Abbas AK. PMID: 12658273.
      View in: PubMed   Mentions: 408     Fields:    Translation:HumansAnimalsCells
    247. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol. 2003 Feb 01; 170(3):1510-6. Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA. PMID: 12538715.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    248. Directed evolution of a single-chain class II MHC product by yeast display. Protein Eng. 2003 Feb; 16(2):147-56. Starwalt SE, Masteller EL, Bluestone JA, Kranz DM. PMID: 12676983.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    249. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala). J Clin Invest. 2003 Feb; 111(3):409-18. Herold KC, Burton JB, Francois F, Poumian-Ruiz E, Glandt M, Bluestone JA. PMID: 12569167.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    250. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol. 2003 Feb; 4(2):182-8. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. PMID: 12524538.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    251. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003 Jan 06; 197(1):129-35. Chikuma S, Imboden JB, Bluestone JA. PMID: 12515820.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    252. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity. 2003 Jan; 18(1):41-51. Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL. PMID: 12530974.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    253. The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells. Novartis Found Symp. 2003; 252:55-63; discussion 63-6, 106-14. Boden E, Tang Q, Bour-Jordan H, Bluestone JA. PMID: 14609212.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    254. CTLA-4 and tolerance: the biochemical point of view. Immunol Res. 2003; 28(3):241-53. Chikuma S, Bluestone JA. PMID: 14713717.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    255. When ligand becomes receptor--tolerance via B7 signaling on DCs. Nat Immunol. 2002 Nov; 3(11):1056-7. Finger EB, Bluestone JA. PMID: 12407416.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    256. Immunotherapy of insulin-dependent diabetes mellitus. Curr Opin Immunol. 2002 Oct; 14(5):652-9. Masteller EL, Bluestone JA. PMID: 12183168.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    257. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J Rheumatol. 2002 Sep; 29(9):1907-13. Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. PMID: 12233885.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
    258. Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J Immunol. 2002 Jul 15; 169(2):633-7. Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML. PMID: 12097362.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    259. The immune tolerance network: a new paradigm for developing tolerance-inducing therapies. J Allergy Clin Immunol. 2002 Jul; 110(1):17-23. Rotrosen D, Matthews JB, Bluestone JA. PMID: 12110811.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    260. Inability to induce tolerance through direct antigen presentation. Am J Transplant. 2002 Jul; 2(6):510-9. Rulifson IC, Szot GL, Palmer E, Bluestone JA. PMID: 12118894.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    261. CTLA-4: acting at the synapse. Mol Interv. 2002 Jul; 2(4):205-8. Chikuma S, Bluestone JA. PMID: 14993389.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    262. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med. 2002 May 30; 346(22):1692-8. Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA. PMID: 12037148.
      View in: PubMed   Mentions: 391     Fields:    Translation:HumansCTClinical Trials
    263. The Src family kinase Fyn mediates signals induced by TCR antagonists. J Immunol. 2002 May 01; 168(9):4480-7. Tang Q, Subudhi SK, Henriksen KJ, Long CG, Vives F, Bluestone JA. PMID: 11970992.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    264. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eur J Immunol. 2002 04; 32(4):972-81. Eagar TN, Karandikar NJ, Bluestone JA, Miller SD. PMID: 11920563.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCellsPHPublic Health
    265. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J Exp Med. 2001 Sep 03; 194(5):677-84. Salomon B, Rhee L, Bour-Jordan H, Hsin H, Montag A, Soliven B, Arcella J, Girvin AM, Padilla J, Miller SD, Bluestone JA. PMID: 11535635.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    266. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide. J Immunol. 2001 Sep 01; 167(5):2555-60. O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA. PMID: 11509595.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    267. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest. 2001 Sep; 108(6):895-903. Wells AD, Walsh MC, Bluestone JA, Turka LA. PMID: 11560959.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    268. Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease. J Immunol. 2001 Aug 15; 167(4):1996-2003. Tesciuba AG, Subudhi S, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AI. PMID: 11489981.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    269. The immune tolerance network and rheumatic disease: immune tolerance comes to the clinic. Arthritis Rheum. 2001 Aug; 44(8):1730-5. Diamond B, Bluestone J, Wofsy D. PMID: 11508422.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    270. Suppressor T cells--they're back and critical for regulation of autoimmunity! Immunol Rev. 2001 Aug; 182:149-63. Chatenoud L, Salomon B, Bluestone JA. PMID: 11722631.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    271. ICOS costimulation: It's not just for TH2 cells anymore. Nat Immunol. 2001 Jul; 2(7):573-4. Sperling AI, Bluestone JA. PMID: 11429535.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    272. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. J Exp Med. 2001 Jun 04; 193(11):1327-32. Wu Q, Salomon B, Chen M, Wang Y, Hoffman LM, Bluestone JA, Fu YX. PMID: 11390440.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    273. Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells. J Immunol. 2001 Jun 01; 166(11):6491-9. Donepudi M, Raychaudhuri P, Bluestone JA, Mokyr MB. PMID: 11359799.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    274. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2001 Jun; 21(6):1011-6. Reardon CA, Blachowicz L, White T, Cabana V, Wang Y, Lukens J, Bluestone J, Getz GS. PMID: 11397712.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    275. The Immune Tolerance Network: tolerance at the crossroads. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):773-6. Bluestone JA, Matthews J. PMID: 11375080.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    276. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant. 2001 May; 1(1):38-46. Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newel KA, Thistlethwaite JR, Bluestone JA, Alegre ML. PMID: 12095035.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    277. Development and applications of surface-linked single chain antibodies against T-cell antigens. J Immunol Methods. 2001 Feb 01; 248(1-2):77-90. Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA. PMID: 11223070.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    278. Transplantation and the CD28/CTLA4/B7 pathway. Transplant Proc. 2001 Feb-Mar; 33(1-2):209-11. Alegre M, Fallarino F, Zhou P, Frauwirth K, Thistlethwaite J, Newell K, Gajewski T, Bluestone J. PMID: 11266782.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    279. Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig. Transplant Proc. 2001 Feb-Mar; 33(1-2):214-6. Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M. PMID: 11266784.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    280. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol. 2001; 19:225-52. Salomon B, Bluestone JA. PMID: 11244036.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansAnimalsCells
    281. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000 Nov 15; 165(10):5580-7. Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML. PMID: 11067913.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    282. The immune tolerance network: the "Holy Grail" comes to the clinic. J Am Soc Nephrol. 2000 Nov; 11(11):2141-2146. Bluestone JA, Matthews JB, Krensky AM. PMID: 11053493.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    283. CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol. 2000 Sep 22; 109(2):173-80. Karandikar NJ, Eagar TN, Vanderlugt CL, Bluestone JA, Miller SD. PMID: 10996219.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    284. CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease. J Virol. 2000 Sep; 74(18):8349-57. Neville KL, Dal Canto MC, Bluestone JA, Miller SD. PMID: 10954534.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    285. The immune tolerance network--an NIH/JDF-supported initiative to bring tolerance research into the clinic: a major new resource for clinical immunologists. Clin Immunol. 2000 Sep; 96(3):171-3. Bluestone JA, Matthews JB. PMID: 10964534.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    286. Evidence for functional relevance of CTLA-4 in ultraviolet-radiation-induced tolerance. J Immunol. 2000 Aug 15; 165(4):1824-31. Schwarz A, Beissert S, Grosse-Heitmeyer K, Gunzer M, Bluestone JA, Grabbe S, Schwarz T. PMID: 10925260.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    287. Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells. J Immunol. 2000 Jun 15; 164(12):6230-6. Sojka DK, Donepudi M, Bluestone JA, Mokyr MB. PMID: 10843675.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    288. Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152). J Immunol. 2000 May 01; 164(9):4433-42. Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, Fallarino F, Collins M, Segal DM, Gajewski TF, Kranz DM, Bluestone JA. PMID: 10779742.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    289. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000 Apr; 12(4):431-40. Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. PMID: 10795741.
      View in: PubMed   Mentions: 641     Fields:    Translation:AnimalsCells
    290. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation. 2000 Mar 15; 69(5):904-9. Szot GL, Zhou P, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR. PMID: 10755548.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    291. In vitro characterization of five humanized OKT3 effector function variant antibodies. Cell Immunol. 2000 Feb 25; 200(1):16-26. Xu D, Alegre ML, Varga SS, Rothermel AL, Collins AM, Pulito VL, Hanna LS, Dolan KP, Parren PW, Bluestone JA, Jolliffe LK, Zivin RA. PMID: 10716879.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    292. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. J Immunol. 2000 Jan 15; 164(2):670-8. Vanderlugt CL, Neville KL, Nikcevich KM, Eagar TN, Bluestone JA, Miller SD. PMID: 10623809.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    293. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. J Immunol. 2000 Jan 01; 164(1):136-43. Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD. PMID: 10605004.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    294. Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol. 2000 Jan 01; 164(1):308-18. Korthäuer U, Nagel W, Davis EM, Le Beau MM, Menon RS, Mitchell EO, Kozak CA, Kolanus W, Bluestone JA. PMID: 10605025.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    295. Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation. J Immunol. 1999 Dec 15; 163(12):6725-31. Beissert S, Bluestone JA, Mindt I, Voskort M, Metze D, Mehling A, Luger TA, Schwarz T, Grabbe S. PMID: 10586070.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    296. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 1999 Dec 06; 190(11):1657-68. Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA. PMID: 10587356.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    297. CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice. Am J Respir Cell Mol Biol. 1999 Oct; 21(4):498-509. Mathur M, Herrmann K, Qin Y, Gulmen F, Li X, Krimins R, Weinstock J, Elliott D, Bluestone JA, Padrid P. PMID: 10502560.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    298. Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection. Transplantation. 1999 Sep 15; 68(5):608-16. Woodle ES, Xu D, Zivin RA, Auger J, Charette J, O'Laughlin R, Peace D, Jollife LK, Haverty T, Bluestone JA, Thistlethwaite JR. PMID: 10507477.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    299. Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells. J Immunol. 1999 Sep 01; 163(5):2358-62. Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA. PMID: 10452966.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    300. Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis). Transplantation. 1999 Aug 15; 68(3):331-7. Theriault BR, Thistlethwaite JR, Levisetti MG, Wardrip CL, Szot G, Bruce DS, Rilo H, Li X, Gray GS, Bluestone JA, Padrid PA. PMID: 10459535.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    301. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol. 1999 May 15; 162(10):5784-91. Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. PMID: 10229811.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    302. Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4. Cancer Res. 1999 May 01; 59(9):2096-101. Richards J, Auger J, Peace D, Gale D, Michel J, Koons A, Haverty T, Zivin R, Jolliffe L, Bluestone JA. PMID: 10232594.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    303. Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism. J Immunol. 1999 Apr 15; 162(8):4817-23. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. PMID: 10202025.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    304. CD2 and CD3 receptor-mediated tolerance: constraints on T cell activation. Transplantation. 1999 Mar 15; 67(5):741-8. Punch JD, Lin J, Bluestone J, Bromberg JS. PMID: 10096532.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    305. TCRgammadelta cells and viruses. Microbes Infect. 1999 Mar; 1(3):203-12. Sciammas R, Bluestone JA. PMID: 10801231.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    306. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol. 1999 Feb 01; 162(3):1270-7. Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB. PMID: 9973379.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    307. Activation and peripheral expansion of murine T-cell receptor gamma delta intraepithelial lymphocytes. Gastroenterology. 1999 Feb; 116(2):327-34. Guehler SR, Bluestone JA, Barrett TA. PMID: 9922313.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    308. The CTLA-4 gene is expressed in placental fibroblasts. Mol Hum Reprod. 1999 Jan; 5(1):84-7. Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C. PMID: 10050667.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    309. Molecular basis of T cell inactivation by CTLA-4. Science. 1998 Dec 18; 282(5397):2263-6. Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA. PMID: 9856951.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    310. Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells. J Immunol. 1998 Dec 15; 161(12):6552-8. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. PMID: 9862681.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    311. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res. 1998 Dec 01; 58(23):5301-4. Mokyr MB, Kalinichenko T, Gorelik L, Bluestone JA. PMID: 9850053.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    312. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol. 1998 Nov 15; 161(10):5138-42. Salomon B, Bluestone JA. PMID: 9820482.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    313. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. J Immunol. 1998 Nov 15; 161(10):5187-92. Sciammas R, Bluestone JA. PMID: 9820489.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    314. Signalling through the TCR. Res Immunol. 1998 Nov-Dec; 149(9):866-7. Cantrell D, Bluestone J, Vivier E, Tybulewicz V. PMID: 9923642.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    315. Cell fate in the immune system: decisions, decisions, decisions. Immunol Rev. 1998 Oct; 165:5-12. Bluestone JA. PMID: 9850847.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    316. Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease. J Neuroimmunol. 1998 Aug 14; 89(1-2):10-8. Karandikar NJ, Vanderlugt CL, Bluestone JA, Miller SD. PMID: 9726820.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    317. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol. 1998 Aug 01; 161(3):1516-24. Ma Y, Thornton S, Duwel LE, Boivin GP, Giannini EH, Leiden JM, Bluestone JA, Hirsch R. PMID: 9686619.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    318. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunol Rev. 1998 Aug; 164:63-72. Vanderlugt CL, Begolka WS, Neville KL, Katz-Levy Y, Howard LM, Eagar TN, Bluestone JA, Miller SD. PMID: 9795764.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    319. Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. J Immunol. 1998 Jul 01; 161(1):192-9. Karandikar NJ, Vanderlugt CL, Eagar T, Tan L, Bluestone JA, Miller SD. PMID: 9647224.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    320. Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience. Transplant Proc. 1998 Jun; 30(4):1369-70. Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR. PMID: 9636555.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    321. Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes. J Immunol. 1998 Jun 01; 160(11):5341-6. Guehler SR, Finch RJ, Bluestone JA, Barrett TA. PMID: 9605133.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    322. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J Exp Med. 1998 May 18; 187(10):1699-709. Chau LA, Bluestone JA, Madrenas J. PMID: 9584148.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    323. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol. 1998 May 15; 160(10):4841-9. Smith JA, Tang Q, Bluestone JA. PMID: 9590231.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    324. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J Immunol. 1998 Apr 15; 160(8):3855-60. Walunas TL, Bluestone JA. PMID: 9558090.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    325. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):453-62. Padrid PA, Mathur M, Li X, Herrmann K, Qin Y, Cattamanchi A, Weinstock J, Elliott D, Sperling AI, Bluestone JA. PMID: 9533932.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    326. Importance of the B7-2 molecule for low dose melphalan-induced acquisition of tumor-eradicating immunity by mice bearing a large MOPC-315 tumor. J Immunol. 1998 Feb 15; 160(4):1866-74. Mokyr MB, Kalinichenko TV, Gorelik L, Bluestone JA. PMID: 9469448.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    327. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol. 1997 Dec 01; 159(11):5187-91. Levisetti MG, Padrid PA, Szot GL, Mittal N, Meehan SM, Wardrip CL, Gray GS, Bruce DS, Thistlethwaite JR, Bluestone JA. PMID: 9548454.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    328. Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE. J Neuroimmunol. 1997 Nov; 79(2):113-8. Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD. PMID: 9394783.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    329. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol. 1997 Nov 01; 159(9):4150-3. Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA. PMID: 9379007.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    330. Transplantation tolerance--putting the pieces together. Curr Opin Immunol. 1997 Oct; 9(5):631-3. Lechler R, Bluestone JA. PMID: 9368770.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    331. T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. Curr Opin Immunol. 1997 Oct; 9(5):648-54. Smith JA, Bluestone JA. PMID: 9368773.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    332. Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res. 1997 Sep 15; 57(18):4036-41. Yang YF, Zou JP, Mu J, Wijesuriya R, Ono S, Walunas T, Bluestone J, Fujiwara H, Hamaoka T. PMID: 9307290.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    333. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med. 1997 Jul 21; 186(2):229-38. Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H. PMID: 9221752.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCellsPHPublic Health
    334. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. J Immunol. 1997 Jul 01; 159(1):86-91. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. PMID: 9200442.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    335. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. PMID: 9166426.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    336. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J Exp Med. 1997 Apr 21; 185(8):1413-22. Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA. PMID: 9126922.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    337. Is CTLA-4 a master switch for peripheral T cell tolerance? J Immunol. 1997 Mar 01; 158(5):1989-93. Bluestone JA. PMID: 9036940.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    338. Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J Immunol. 1997 Mar 01; 158(5):2156-64. Woodle ES, Smith DM, Bluestone JA, Kirkman WM, Green DR, Skowronski EW. PMID: 9036961.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    339. Class I MHC mediates programmed cell death in a Fas-independent manner. Transplant Proc. 1997 Feb-Mar; 29(1-2):1101. Woodle ES, Smith DM, Bluestone JA, Green DR, Skowronski EW. PMID: 9123218.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    340. CD28/B7 regulation of autoimmune diabetes. Immunol Res. 1997 Feb; 16(1):71-84. Herold KG, Lenschow DJ, Bluestone JA. PMID: 9048209.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    341. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med. 1997 Jan 20; 185(2):219-29. Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. PMID: 9016871.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    342. CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. J Immunol. 1997 Jan 15; 158(2):984-91. Herold KC, Vezys V, Koons A, Lenschow D, Thompson C, Bluestone JA. PMID: 8993020.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    343. CD28 costimulation promotes the production of Th2 cytokines. J Immunol. 1997 Jan 15; 158(2):658-65. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. PMID: 8992981.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    344. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J Immunol. 1996 Nov 01; 157(9):3909-17. Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA. PMID: 8892622.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    345. The complexities of T-cell co-stimulation: CD28 and beyond. Immunol Rev. 1996 Oct; 153:155-82. Sperling AI, Bluestone JA. PMID: 9010723.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    346. TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen. J Immunol. 1996 Sep 15; 157(6):2320-7. Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA. PMID: 8805629.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    347. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 1996 Sep; 5(3):285-93. Lenschow DJ, Herold KC, Rhee L, Patel B, Koons A, Qin HY, Fuchs E, Singh B, Thompson CB, Bluestone JA. PMID: 8808683.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    348. Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts. J Exp Med. 1996 Aug 01; 184(2):493-503. Guehler SR, Bluestone JA, Barrett TA. PMID: 8760803.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    349. CTLA-4: a negative regulator of autoimmune disease. J Exp Med. 1996 Aug 01; 184(2):783-8. Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA. PMID: 8760834.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    350. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med. 1996 Jun 01; 183(6):2541-50. Walunas TL, Bakker CY, Bluestone JA. PMID: 8676075.
      View in: PubMed   Mentions: 220     Fields:    Translation:AnimalsCells
    351. Regulation of CTLA-4 expression during T cell activation. J Immunol. 1996 Jun 01; 156(11):4154-9. Perkins D, Wang Z, Donovan C, He H, Mark D, Guan G, Wang Y, Walunas T, Bluestone J, Listman J, Finn PW. PMID: 8666782.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    352. Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens. Blood. 1996 May 15; 87(10):4463-72. Blazar BR, Taylor PA, Bluestone JA, Vallera DA. PMID: 8639809.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    353. In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells. Transplantation. 1996 Mar 15; 61(5):798-803. Woodle ES, Hussein S, Bluestone JA. PMID: 8607186.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    354. Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule. Cancer Immunol Immunother. 1996 Mar; 42(3):161-9. La Motte RN, Rubin MA, Barr E, Leiden JM, Bluestone JA, Mokyr MB. PMID: 8640844.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    355. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol. 1996 Feb 01; 156(3):1006-13. Walunas TL, Sperling AI, Khattri R, Thompson CB, Bluestone JA. PMID: 8557973.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    356. Costimulation and its role in organ transplantation. Clin Transplant. 1996 Feb; 10(1 Pt 2):104-9. Bluestone JA. PMID: 8680045.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    357. IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. J Immunol. 1996 Jan 15; 156(2):663-9. Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y. PMID: 8543818.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    358. Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens. Blood. 1996 Jan 15; 87(2):827-37. Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Barrett TA, Bluestone JA, Vallera DA. PMID: 8555509.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    359. CD28/B7 system of T cell costimulation. Annu Rev Immunol. 1996; 14:233-58. Lenschow DJ, Walunas TL, Bluestone JA. PMID: 8717514.
      View in: PubMed   Mentions: 576     Fields:    Translation:HumansAnimalsCells
    360. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity. 1995 Dec; 3(6):739-45. Miller SD, Vanderlugt CL, Lenschow DJ, Pope JG, Karandikar NJ, Dal Canto MC, Bluestone JA. PMID: 8777719.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    361. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies. Transplantation. 1995 Nov 27; 60(10):1171-8. Lenschow DJ, Zeng Y, Hathcock KS, Zuckerman LA, Freeman G, Thistlethwaite JR, Gray GS, Hodes RJ, Bluestone JA. PMID: 7482727.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    362. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995 Nov; 3(5):541-7. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. PMID: 7584144.
      View in: PubMed   Mentions: 820     Fields:    Translation:AnimalsCells
    363. Development of TCR gamma delta iIELs. Semin Immunol. 1995 Oct; 7(5):299-305. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Barrett TA, Bluestone JA. PMID: 8580462.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    364. Transplantation. Curr Opin Immunol. 1995 Oct; 7(5):617-9. Bluestone JA, Lechler RI. PMID: 8573302.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    365. Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent. J Immunol. 1995 Sep 01; 155(5):2379-86. Kaliyaperumal A, Falchetto R, Cox A, Dick R, Shabanowitz J, Chien YH, Matis L, Hunt DF, Bluestone JA. PMID: 7650372.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    366. Ly-6C is a marker of memory CD8+ T cells. J Immunol. 1995 Aug 15; 155(4):1873-83. Walunas TL, Bruce DS, Dustin L, Loh DY, Bluestone JA. PMID: 7543536.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    367. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol. 1995 Aug 01; 155(3):1544-55. Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA. PMID: 7636216.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    368. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol. 1995 Aug 01; 155(3):1032-6. Kearney ER, Walunas TL, Karr RW, Morton PA, Loh DY, Bluestone JA, Jenkins MK. PMID: 7543510.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    369. Two waves of gamma delta T cells expressing different V delta genes are recruited into schistosome-induced liver granulomas. J Immunol. 1995 Jul 01; 155(1):275-84. Sandor M, Sperling AI, Cook GA, Weinstock JV, Lynch RG, Bluestone JA. PMID: 7602105.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    370. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995 Jul 01; 182(1):139-46. Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB. PMID: 7790813.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    371. New perspectives of CD28-B7-mediated T cell costimulation. Immunity. 1995 Jun; 2(6):555-9. Bluestone JA. PMID: 7540940.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    372. T cell costimulation through the CD28 receptor. Proc Assoc Am Physicians. 1995 Apr; 107(1):41-6. Green JM, Noel PJ, Sperling AI, Walunas TL, Lenschow DJ, Stack R, Gray GS, Bluestone JA, Thompson CB. PMID: 8630743.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    373. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med. 1995 Mar 01; 181(3):1145-55. Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA. PMID: 7532678.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    374. Inhibition of T-cell activation by an anti-human class I MHC reactive monoclonal antibody occurs at a point distal to TCR-CD3 mediated signal transduction. Transplant Proc. 1995 Feb; 27(1):395-7. Smith DM, Bluestone JA, Thistlethwaite JR, Woodle ES. PMID: 7879035.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    375. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27; 270(4):1928-34. Hu Q, Davidson D, Schwartzberg PL, Macchiarini F, Lenardo MJ, Bluestone JA, Matis LA. PMID: 7829530.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    376. Programmed differentiation of murine thymocytes during fetal thymus organ culture. J Immunol Methods. 1995 Jan 13; 178(1):13-29. DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. PMID: 7829862.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    377. Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors. Dig Dis Sci. 1995 Jan; 40(1):58-64. Alegre ML, Lenschow DJ, Bluestone JA. PMID: 7821120.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    378. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol. 1995; 11:307-53. Bluestone JA, Khattri R, Sciammas R, Sperling AI. PMID: 8689560.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    379. Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication. J Immunol. 1994 Oct 01; 153(7):3123-34. Mokyr MB, Prokhorova A, Rubin M, Bluestone JA. PMID: 8089490.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    380. Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies. Transplantation. 1994 Sep 27; 58(6):681-9. Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA. PMID: 7940687.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    381. Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol. 1994 Sep 15; 153(6):2738-49. Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR. PMID: 8077678.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    382. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol. 1994 Sep 01; 153(5):1990-7. Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA. PMID: 7519638.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    383. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1994 Sep; 1(6):501-8. Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, Thompson CB. PMID: 7534617.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    384. Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules. J Immunol. 1994 Aug 01; 153(3):1054-67. Smith DM, Bluestone JA, Jeyarajah DR, Newberg MH, Engelhard VH, Thistlethwaite JR, Woodle ES. PMID: 7913109.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    385. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994 Aug; 1(5):405-13. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. PMID: 7882171.
      View in: PubMed   Mentions: 584     Fields:    Translation:HumansAnimalsCells
    386. The B7 and CD28 receptor families. Immunol Today. 1994 Jul; 15(7):321-31. June CH, Bluestone JA, Nadler LM, Thompson CB. PMID: 7522010.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansAnimalsCells
    387. Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model. Transplantation. 1994 Jun 27; 57(12):1786-94. Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA. PMID: 8016885.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    388. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 1994 Jun 15; 57(11):1537-43. Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. PMID: 8009586.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    389. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J Immunol. 1994 Jun 15; 152(12):5723-33. Stack RM, Lenschow DJ, Gray GS, Bluestone JA, Fitch FW. PMID: 7515912.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    390. Prolongation of human pancreatic islet xenografts by pretreatment of islets with anti-human ICAM-1 monoclonal antibody. Transplant Proc. 1994 Jun; 26(3):1120. Zeng Y, Torres MA, Thistlethwaite JR, Montag A, Bluestone JA. PMID: 7913254.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    391. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol. 1994 Jun 01; 152(11):5392-7. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA. PMID: 8189058.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    392. Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases. J Immunol. 1994 Apr 01; 152(7):3522-9. Rubin M, Bluestone JA, Newell KA, Prokhorova A, Mokyr MB. PMID: 8144932.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    393. The nature of major histocompatibility complex recognition by gamma delta T cells. Cell. 1994 Jan 14; 76(1):29-37. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH. PMID: 8287478.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    394. Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture. Thymus. 1994-1995; 23(3-4):131-53. Tatsumi Y, Deluca D, Cron RQ, Bluestone JA. PMID: 8525502.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    395. TCR gamma delta cells: mysterious cells of the immune system. Immunol Res. 1994; 13(4):268-79. Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA. PMID: 7616054.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    396. The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11875-9. Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, Fitch FW. PMID: 8265641.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    397. Role of gamma delta T cells in murine collagen-induced arthritis. J Immunol. 1993 Dec 01; 151(11):6546-58. Peterman GM, Spencer C, Sperling AI, Bluestone JA. PMID: 8245484.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    398. T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas. Cell Immunol. 1993 Dec; 152(2):305-22. Sydora BC, Mixter PF, Houlden B, Hershberg R, Levy R, Comay M, Bluestone J, Kronenberg M. PMID: 8258140.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    399. CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes. J Immunol. 1993 Dec 01; 151(11):6043-50. Sperling AI, Linsley PS, Barrett TA, Bluestone JA. PMID: 8245449.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    400. Expression and functional significance of an additional ligand for CTLA-4. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11054-8. Lenschow DJ, Su GH, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miller J, Bluestone JA. PMID: 7504292.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    401. Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan. J Immunol. 1993 Nov 01; 151(9):4838-46. Mokyr MB, Rubin M, Newell KA, Prokhorova A, Bluestone JA. PMID: 8409442.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    402. Peptide-induced changes in class I heavy chains alter allorecognition. J Immunol. 1993 Oct 15; 151(8):3943-53. Bluestone JA, Kaliyaperumal A, Jameson S, Miller S, Dick R. PMID: 8409378.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    403. T cell co-stimulation and in vivo tolerance. Curr Opin Immunol. 1993 Oct; 5(5):747-52. Lenschow DJ, Bluestone JA. PMID: 7694594.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    404. Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes. Eur J Immunol. 1993 Oct; 23(10):2482-7. Dent AL, Matis LA, Bluestone JA, Hedrick SM. PMID: 8405049.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    405. Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation. J Immunol. 1993 Sep 15; 151(6):3030-41. Tatsumi Y, Pena JC, Matis L, Deluca D, Bluestone JA. PMID: 8376767.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    406. Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):6949-51. Sherman LA, Chattopadhyay S, Biggs JA, Dick RF, Bluestone JA. PMID: 8346201.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    407. Tolerance of T cell receptor gamma/delta cells in the intestine. J Exp Med. 1993 Jun 01; 177(6):1755-62. Barrett TA, Tatsumi Y, Bluestone JA. PMID: 8098732.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    408. Non-classical MHC molecules: the first line of defence? Curr Biol. 1993 May 01; 3(5):294-6. Sperling AI, Bluestone JA. PMID: 15335753.
      View in: PubMed   Mentions:    Fields:    
    409. Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. J Exp Med. 1993 Apr 01; 177(4):1061-70. Wells FB, Tatsumi Y, Bluestone JA, Hedrick SM, Allison JP, Matis LA. PMID: 8459203.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    410. Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat-->B6 mouse). Transplant Proc. 1993 Feb; 25(1 Pt 1):438-9. Zeng Y, Bluestone JA, Ildstad ST, Torres MA, Montag AG, Thistlethwaite RJ. PMID: 8438368.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    411. Immunosuppressive effects of anti-CD3 MAb and soluble co-stimulatory molecules. Transplant Proc. 1993 Feb; 25(1 Pt 1):546-7. Bluestone JA, Bruce D, Peterson L, Thistlethwaite JR, Josephson M, Zeng Y, Linsley PS, Lenschow DJ. PMID: 8438407.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    412. Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier. J Immunol. 1993 Jan 01; 150(1):265-77. Blazar BR, Taylor PA, Snover DC, Bluestone JA, Vallera DA. PMID: 8417127.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    413. Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition. J Exp Med. 1992 Dec 01; 176(6):1757-61. Bluestone JA, Jameson S, Miller S, Dick R. PMID: 1460430.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    414. Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection. J Immunol. 1992 Nov 15; 149(10):3200-7. Sperling AI, Cron RQ, Decker DC, Stern DA, Bluestone JA. PMID: 1431099.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    415. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol. 1992 Aug 15; 149(4):1124-30. Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. PMID: 1380032.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    416. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science. 1992 Aug 07; 257(5071):789-92. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA. PMID: 1323143.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimals
    417. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8. Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA. PMID: 1534096.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    418. Effects of anti-CD3 monoclonal antibody on engraftment of T-cell-depleted bone marrow allografts in mice: host T-cell suppression, growth factors, and space. Blood. 1992 Jun 01; 79(11):3050-8. Hiruma K, Hirsch R, Patchen M, Bluestone JA, Gress RE. PMID: 1534027.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    419. Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression. J Immunol. 1992 May 01; 148(9):2756-63. Woodle ES, Thistlethwaite JR, Jolliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA. PMID: 1533410.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    420. In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors. J Immunol. 1992 Apr 15; 148(8):2363-9. Sandor M, Houlden B, Bluestone J, Hedrick SM, Weinstock J, Lynch RG. PMID: 1532812.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    421. The T cell receptor in autoimmune diseases. J Rheumatol Suppl. 1992 Apr; 33:75-7. Bluestone JA, Spencer C, Hirsch R. PMID: 1534379.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    422. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. J Exp Med. 1992 Mar 01; 175(3):695-707. Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. PMID: 1531495.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    423. Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody. Diabetes. 1992 Mar; 41(3):385-91. Herold KC, Bluestone JA, Montag AG, Parihar A, Wiegner A, Gress RE, Hirsch R. PMID: 1532369.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    424. A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I. J Immunol. 1992 Feb 15; 148(4):983-8. Johnson RM, Lancki DW, Sperling AI, Dick RF, Spear PG, Fitch FW, Bluestone JA. PMID: 1310711.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    425. Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue. J Exp Med. 1992 Jan 01; 175(1):65-70. Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick SM, Bluestone JA. PMID: 1730927.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    426. A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J Exp Med. 1992 Jan 01; 175(1):49-56. Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, Bluestone JA, Nomoto K. PMID: 1530961.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    427. Activation of T cells in vivo using anti-CD3 and staphylococcal enterotoxins. Int J Cancer Suppl. 1992; 7:39-41. Bluestone JA, Bruce DS, Newell KA. PMID: 1428401.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    428. Immunopotentiation of anti-viral and anti-tumor immune responses using anti-T cell receptor antibodies and mitogens. Ann N Y Acad Sci. 1991 Dec 30; 636:279-87. Newell KA, Ellenhorn JD, Hirsch R, Bluestone JA. PMID: 1793214.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    429. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991 Dec 01; 147(11):3736-44. Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, Kiyono H. PMID: 1682383.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    430. Inter-mouse strain differences in the in vivo anti-CD3 induced cytokine release. Clin Exp Immunol. 1991 Dec; 86(3):537-43. Ferran C, Dy M, Sheehan K, Merite S, Schreiber R, Landais P, Grau G, Bluestone J, Bach JF, Chatenoud L. PMID: 1721015.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    431. CD4-CD8- thymocytes from MRL-lpr/lpr mice exhibit abnormal proportions of alpha beta- and gamma delta-TCR+ cells and demonstrate defective responsiveness when activated through the TCR. Cell Immunol. 1991 Oct 15; 137(2):269-82. Kakkanaiah VN, Nagarkatti M, Bluestone JA, Nagarkatti PS. PMID: 1832583.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    432. Cascade modulation by anti-tumor necrosis factor monoclonal antibody of interferon-gamma, interleukin 3 and interleukin 6 release after triggering of the CD3/T cell receptor activation pathway. Eur J Immunol. 1991 Oct; 21(10):2349-53. Ferran C, Dy M, Sheehan K, Schreiber R, Grau G, Bluestone J, Bach JF, Chatenoud L. PMID: 1833202.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    433. Requirement for positive selection of gamma delta receptor-bearing T cells. Science. 1991 Aug 23; 253(5022):903-5. Wells FB, Gahm SJ, Hedrick SM, Bluestone JA, Dent A, Matis LA. PMID: 1831565.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    434. Anti-CD3 monoclonal antibody therapy. An approach toward optimization by in vitro analysis of new anti-CD3 antibodies. Transplantation. 1991 Aug; 52(2):361-8. Woodle ES, Thistlethwaite JR, Jolliffe LK, Fucello AJ, Stuart FP, Bluestone JA. PMID: 1714644.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    435. OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release. Transplantation. 1991 Aug; 52(2):354-60. Woodle ES, Thistlethwaite JR, Ghobrial IA, Jolliffe LK, Stuart FP, Bluestone JA. PMID: 1908148.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    436. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunol Rev. 1991 Apr; 120:5-33. Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, Hedrick S, Rellahan B, Matis LA. PMID: 1650760.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    437. Specificity of gamma delta receptor bearing T cells. Semin Immunol. 1991 Mar; 3(2):75-80. Matis LA, Bluestone JA. PMID: 1716171.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    438. Advantages of F(ab')2 fragments of anti-CD3 monoclonal antibody as compared to whole antibody as immunosuppressive agents in mice. Transplant Proc. 1991 Feb; 23(1 Pt 1):270-1. Hirsch R, Bluestone JA, Bare CV, Gress RE. PMID: 1824981.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    439. T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies. Transplant Proc. 1991 Feb; 23(1 Pt 1):81-2. Woodle ES, Thistlethwaite JR, Jolliffe LK, Ghobrial I, Fuccello AJ, Stuart FP, Bluestone JA. PMID: 1824999.
      View in: PubMed   Mentions: 3