Jeffrey Bluestone, PhD

Title(s)Professor Emeritus, Diabetes Center
SchoolSchool of Medicine
Phone415-514-0417
ORCID ORCID Icon0000-0001-8793-7848 Additional info
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    Other Positions
    Title(s)Professor, School of Medicine


    Collapse Biography 
    Collapse Education and Training
    Cornell Graduate School of Medical SciencePh.D.1980Immunology
    Rutgers - State UniversityM.S1977Microbiology
    Cook College, Rutgers UniversityB.S.1974Biology
    Collapse Awards and Honors
    Gould Foundation 1987  - 1989Faculty Scholar
    American Cancer Society1989Faculty Scholar
    Guggenheim Foundation1997Senior Fellowship
    Fogarty Foundation1997Senior Research Fellowship
    Cornell Medical School1998Distinguished Alumni Award
    Juvenile Diabetes Research Foundation2004Gerold & Kayla Grodsky Basic Science Award
    American Society for Transplantation2004Roche Distinguished Research Award
    Juvenile Diabetes Research Foundation2005Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award
    American Academy of Arts and Sciences2006Elected Member
    Juvenile Diabetes Research Foundation2008Scholar Award
    American Academy of Allergy, Asthma, & Immunology2010Elliott Middleton Memorial Lectureship
    National Academy of Medicine2013Elected Member
    American Society of Transplantation2015Outstanding Mentorship Award
    Federation of Clinical Immunology Societies2015President-Elect
    National Cancer Foundation2016Blue Ribbon Panel on Cancer Research (Biden Moonshot Program)
    Juvenile Diabetes Research Foundation2017David Rumbough Award for Scientific Excellence
    American Association of Immunologists2020Excellence in Mentoring Award
    American Association of Immunologists2022AAI-Steinman Award for Human Immunology Research

    Collapse Overview 
    Collapse Overview
    Jeffrey Bluestone, PhD, is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology and is the Director of the Hormone Research Institute in the Diabetes Center. His research over the past 25 years has focused on understanding the basic processes that control T cell activation and immune tolerance in autoimmunity and organ transplantation. He and members of his lab have developed soluble receptor antagonists; monoclonal antibodies and animals deficient in individual members of TCR and co-stimulatory pathways to define their individual roles in transplant rejection and autoimmunity including a special emphasis on a specialized subset of T cells termed “regulatory T cells” (Treg). Tregs control fundamental aspect of immune homeostasis. During the last several years, his research has adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity and under conditions of allotransplant rejection. Moreover, a strong role for antigen-specific Tregs have been found in these model systems and further evidence in humanized mice and transplant patients that alloantigen-specific Tregs are more effective. Thus, the major goal of this work is to identify the antigen-specificity of thymic- and peripherally-derived Tregs with the expectation that these TCRs can be adapted for immunotherapy. Finally, his lab initiated several projects to determine mechanisms that control Treg stability. The goal is to develop approaches using pharmacogenomics to either stabilize or destabilize Tregs in autoimmunity and cancer.

    In March 2010 Dr. Bluestone was appointed executive vice chancellor and provost at the University of California San Francisco (UCSF) serving as chief academic officer guiding the research and academic enterprise advancing the campus priorities in close collaboration with the chancellor and the campus leadership teams, and to oversee the campus ethics and compliance enterprise. Previously he served in a number of posts including Director of theUCSF Diabetes Center, as Director of the Immune Tolerance Network.

    In June 2008 Dr. Bluestone served as interim vice chancellor of research; directing the advancement of cross-campus research initiatives, such as enhancing core research facilities. In this capacity, he played a leading role in coordinating and integrating current research cores. He worked also to strengthen external research partnerships, particularly with industry, and focused on facilitating the translation of UCSF discoveries into public benefit.

    In 2009, Dr. Bluestone led the UCSF committee to strategize and secure funds available through the American Recovery and Reinvestment Act, making the campus one of the top institutional recipients in the nation of science-based stimulus funds.

    Dr. Bluestone joined the UCSF faculty in 2000. He is an international leader in the field of immunotherapy, with a stellar record of scholarly achievement and a decade of significant contributions to the research enterprise at UCSF, including the creation and directorship of an integrated UCSF Diabetes Center to focus on translating basic research in both type 1 and type 2 diabetes into improved therapies for patients. He also founded and directed the Immune Tolerance Network, a consortium of more than 1,000 of the world’s leading scientific researchers and clinical specialists from nearly 50 institutions, with the mission of testing new therapies to promote immune tolerance in transplantation, autoimmune diseases, asthma and allergic diseases.

    As a research scientist, Dr. Bluestone has helped clarify the body’s immune response on a molecular level. His systematic investigation has catalyzed recent progress in stem cell research, islet cell transplantation and immune tolerance therapies – experimentation that has formidably translated into drugs to treat human disease.

    Through his 30-year scientific career, he has authored more than 300 peer-reviewed publications that include prominent papers in Nature, Nature Immunology, and the Journal of Immunology and Diabetes. He has received numerous accolades for his work, including his 2006 election to the American Academy of Arts and Sciences, the Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation, and the distinguished alumni award from the Cornell Graduate School of Medical Science.

    Prior to joining UCSF, Bluestone was at the University of Chicago, where he was a member of the Ben May Institute for Cancer Research, rising over 13 years from an associate professor to the director of the institute. He had previously worked for seven years in various roles at the National Cancer Institute of the National Institutes of Health, ultimately becoming a senior investigator in the Immunology Branch of the National Cancer Institute.

    Dr. Bluestone earned both his BS in biology and his MS in microbiology from Rutgers State University, and his PhD in immunology from the Cornell Graduate School of Medical Science (Sloan-Kettering Division).
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Designer Tregs for restoring tolerance in patients with type 1 diabetes
    NIH UC4DK116264Sep 20, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH U01DK107383Jul 1, 2016 - Dec 31, 2020
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK R01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Co-Principal Investigator
    Disruption of T cell tolerance in type 1 diabetes
    NIH P01AI118688Jun 8, 2016 - May 31, 2021
    Role: Co-Investigator
    Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation
    NIH U01AI110658Jun 1, 2014 - May 31, 2021
    Role: Co-Principal Investigator
    Autoimmunity Center of Excellence Clinical Research Program
    NIH UM1AI110498May 1, 2014 - Apr 30, 2020
    Role: Co-Investigator
    Role of Innate Lymphoid Cells in Autoimmunity
    NIH R21AI107328Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    Donor-Specific Regulatory T Cell Therapy in Liver Transplantation
    NIH R34AI095135Apr 1, 2012 - Mar 31, 2014
    Role: Co-Principal Investigator
    Expanding beta-cell mass
    NIH U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Role of Notch 1 in Immune Tolerance
    NIH R21AI059979Apr 1, 2004 - Mar 31, 2007
    Role: Principal Investigator
    Autoimmunity Center of Excellence
    NIH U19AI056388Sep 30, 2003 - Apr 30, 2015
    Role: Co-Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Principal Investigator
    Conf on Mechanism and Applications of Immune Tolerance
    NIH R13AI051294Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    Spontaneous Autoimmune Model of Peripheral Neuropathy
    NIH R01AI050834Dec 15, 2001 - Nov 30, 2012
    Role: Principal Investigator
    Immune tolerance network: lung transplantation
    NIH N01AI15416-20-0-10Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: liver transplantation
    NIH N01AI15416-20-0-11Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Systemic lupus rythematosus (SLE)
    NIH N01AI15416-20-0-12Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Kidney, Liver and Bone Marrow Transplantation
    NIH N01AI15416-20-0-2Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Food Allergy
    NIH N01AI15416-20-0-3Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Type 1 diabetes
    NIH N01AI15416-20-0-4Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Multiple sclerosis
    NIH N01AI15416-20-0-5Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Rheumatoid arthritis
    NIH N01AI15416-20-0-6Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Autoimmune diseases: Vasculitis
    NIH N01AI15416-20-0-7Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Islet cell transplantation
    NIH N01AI15416-20-0-8Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: heart tranplantation
    NIH N01AI15416-20-0-9Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: liver transplantation
    NIH N01AI15416-23-0-11Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Systemic lupus rythematosus (SLE)
    NIH N01AI15416-23-0-12Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: kidney transplantation
    NIH N01AI15416-23-0-13Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    IImmune Tolerance Network: Airborne Allergens and Allergic Rhintitis
    NIH N01AI15416-23-0-14Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Food Allergy
    NIH N01AI15416-23-0-3Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune Tolerance Network: Type 1 diabetes
    NIH N01AI15416-23-0-4Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    Immune tolerance network: Multiple sclerosis
    NIH N01AI15416-23-0-5Sep 30, 2001 - Apr 30, 2014
    Role: Principal Investigator
    FASEB SUMMER CONFERENCE--LYMPHOCYTES AND ANTIBODIES
    NIH R13AI047114Jun 1, 2000 - May 31, 2001
    Role: Principal Investigator
    Immunomodulation of transplant rejection by Anti-CD3 mAb
    NIH R01AI046643Mar 1, 2000 - Nov 30, 2016
    Role: Principal Investigator
    IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB
    NIH R37AI046643Mar 1, 2000 - Feb 28, 2011
    Role: Principal Investigator
    MOFLO MULTILASER FLOW CYTOMETER
    NIH S10RR014884Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    COLLABORATIVE NETWORK FOR CLINICAL RES ON IMMUNE TOLERAN
    NIH/NIAID N01AI095380Sep 30, 1999 - Sep 29, 2006
    Role: Principal Investigator
    TOLERANCE OF ISLET CELL GRAFT
    NIH R01DK055351Jun 15, 1999 - May 31, 2003
    Role: Principal Investigator
    CTLA 4 ANTAGONISM DURING T CELL ACTIVATION
    NIH F33AI009895Mar 22, 1998
    Role: Principal Investigator
    SCOR in Cellular and Molecular Mechanisms of Asthma
    NIH P50HL056399Sep 30, 1996 - Aug 31, 2006
    Role: Co-Principal Investigator
    IMMUNOREGULATION OF IDDM
    NIH P01DK049799Jun 15, 1995 - May 31, 2000
    Role: Co-Investigator
    COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    NIH P01AI035294Sep 1, 1993 - Aug 31, 2001
    Role: Principal Investigator
    IMMUNOMODULATION OF TRANSPLANT REJECTION
    NIH P01AI029531Jun 1, 1990 - Aug 31, 2000
    Role: Principal Investigator
    IMMUNOBIOLOGY OF TCR GAMMA/DELTA T-CELLS
    NIH R01AI026847Sep 1, 1988 - Aug 31, 1999
    Role: Principal Investigator
    IN VIVO POTENTIATION OF IMMUNE RESPONSES
    NIH R01CA049260Aug 5, 1988 - Jul 31, 1995
    Role: Principal Investigator
    Interdisciplinary Training Program in Immunology
    NIH T32AI007090Jul 1, 1979 - Jun 30, 2024
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA014599Feb 1, 1977 - Mar 31, 2018
    Role: Co-Investigator
    IMMUNITY AND CANCER
    NIH P01CA019266Jun 1, 1976 - Mar 31, 1996
    Role: Co-Investigator
    Immune Tolerance and Autoimmunity
    NIH P01AI035297Jul 31, 2012
    Role: Co-Investigator
    Immune Tolerance Network: Autoimmune Diseases
    NIH/NIAID N01AI15416
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rebalancing the Immune System to Treat Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024 Sep 16. Muller YD, Ho P, Bluestone JA, Tang Q. PMID: 39284666.
      View in: PubMed   Mentions:    Fields:    
    2. The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation. Cold Spring Harb Perspect Med. 2024 Sep 16. Chatenoud L, Herold KC, Bach JF, Bluestone JA. PMID: 39284671.
      View in: PubMed   Mentions:    Fields:    
    3. Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones. Proc Natl Acad Sci U S A. 2024 May 14; 121(20):e2320268121. Smith JA, Yuen BTK, Purtha W, Balolong JM, Phipps JD, Crawford F, Bluestone JA, Kappler JW, Anderson MS. PMID: 38709934; PMCID: PMC11098115.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Harnessing regulatory T cells to establish immune tolerance. Sci Transl Med. 2024 Mar 13; 16(738):eadm8859. Ho P, Cahir-McFarland E, Fontenot JD, Lodie T, Nada A, Tang Q, Turka LA, Bluestone JA. PMID: 38478632.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Opportunities for Treg cell therapy for the treatment of human disease. Front Immunol. 2023; 14:1166135. Bluestone JA, McKenzie BS, Beilke J, Ramsdell F. PMID: 37153574; PMCID: PMC10154599.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    6. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis. J Endocr Soc. 2023 Feb 09; 7(4):bvad012. Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang JH, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto AL, Herold K, Lechner MG, Su MA, Tyrrell JB, Bluestone J, Anderson M, Masharani U. PMID: 36860908; PMCID: PMC9969737.
      View in: PubMed   Mentions: 8  
    7. Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Sci Transl Med. 2022 11 09; 14(670):eabm1463. Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT. PMID: 36350984; PMCID: PMC9939256.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    8. Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. Cell Rep. 2022 10 18; 41(3):111478. VanDyke D, Iglesias M, Tomala J, Young A, Smith J, Perry JA, Gebara E, Cross AR, Cheung LS, Dykema AG, Orcutt-Jahns BT, Henclová T, Golias J, Balolong J, Tomasovic LM, Funda D, Meyer AS, Pardoll DM, Hester J, Issa F, Hunter CA, Anderson MS, Bluestone JA, Raimondi G, Spangler JB. PMID: 36261022; PMCID: PMC9631798.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    9. BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood. 2022 05 12; 139(19):2983-2997. Zaiken MC, Flynn R, Paz KG, Rhee SY, Jin S, Mohamed FA, Saha A, Thangavelu G, Park PMC, Hemming ML, Sage PT, Sharpe AH, DuPage M, Bluestone JA, Panoskaltsis-Mortari A, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Luznik L, Maillard I, Hill GR, MacDonald KPA, Munn DH, Serody JS, Murphy WJ, Kean LS, Zhang Y, Bradner JE, Qi J, Blazar BR. PMID: 35226736; PMCID: PMC9101246.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Multiple early factors anticipate post-acute COVID-19 sequelae. Cell. 2022 03 03; 185(5):881-895.e20. Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J, Li S, Hong S, Zhang R, Xie J, Kornilov SA, Scherler K, Pavlovitch-Bedzyk AJ, Dong S, Lausted C, Lee I, Fallen S, Dai CL, Baloni P, Smith B, Duvvuri VR, Anderson KG, Li J, Yang F, Duncombe CJ, McCulloch DJ, Rostomily C, Troisch P, Zhou J, Mackay S, DeGottardi Q, May DH, Taniguchi R, Gittelman RM, Klinger M, Snyder TM, Roper R, Wojciechowska G, Murray K, Edmark R, Evans S, Jones L, Zhou Y, Rowen L, Liu R, Chour W, Algren HA, Berrington WR, Wallick JA, Cochran RA, Micikas ME, ISB-Swedish COVID-19 Biobanking Unit, Wrin T, Petropoulos CJ, Cole HR, Fischer TD, Wei W, Hoon DSB, Price ND, Subramanian N, Hill JA, Hadlock J, Magis AT, Ribas A, Lanier LL, Boyd SD, Bluestone JA, Chu H, Hood L, Gottardo R, Greenberg PD, Davis MM, Goldman JD, Heath JR. PMID: 35216672; PMCID: PMC8786632.
      View in: PubMed   Mentions: 461     Fields:    Translation:HumansCells
    11. Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience. Front Immunol. 2021; 12:744763. Balcerek J, Shy BR, Putnam AL, Masiello LM, Lares A, Dekovic F, Acevedo L, Lee MR, Nguyen V, Liu W, Paruthiyil S, Xu J, Leinbach AS, Bluestone JA, Tang Q, Esensten JH. PMID: 34867967; PMCID: PMC8636860.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    12. The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes. JCI Insight. 2021 09 22; 6(18). Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. PMID: 34324441; PMCID: PMC8492314.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCellsCTClinical Trials
    13. Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance. Front Immunol. 2021; 12:686439. Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, Zhou Y, Lee K, Leung KK, Skartsis N, Kaul AM, Mulder A, Claas FHJ, Wells JA, Bluestone JA, Tang Q. PMID: 34616392; PMCID: PMC8488356.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    14. Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR. J Immunother Cancer. 2021 09; 9(9). Bayless NL, Bluestone JA, Bucktrout S, Butterfield LH, Jaffee EM, Koch CA, Roep BO, Sharpe AH, Murphy WJ, Villani AC, Walunas TL. PMID: 34479924; PMCID: PMC8420733.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    15. Immunotherapy: Building a bridge to a cure for type 1 diabetes. Science. 2021 Jul 30; 373(6554):510-516. Bluestone JA, Buckner JH, Herold KC. PMID: 34326232.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    16. Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2021 08; 9(8):502-514. Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, Wentworth JM, Willi SM, Krischer JP, Bluestone JA, Gleevec Trial Study Group. PMID: 34214479; PMCID: PMC8494464.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
    17. The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Front Immunol. 2021; 12:639818. Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q. PMID: 33833759; PMCID: PMC8021955.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    18. Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines. Trends Immunol. 2021 04; 42(4):293-311. Kang JH, Bluestone JA, Young A. PMID: 33714688.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    19. At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity. Cancer Discov. 2021 03; 11(3):537-539. Young A, Bluestone JA. PMID: 33653918.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    20. Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19. Cell. 2020 12 10; 183(6):1479-1495.e20. Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai CL, Voillet V, Duvvuri VR, Scherler K, Troisch P, Baloni P, Qin G, Smith B, Kornilov SA, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Heath JE, Earls J, Zhang R, Xie J, Li S, Roper R, Jones L, Zhou Y, Rowen L, Liu R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Zager MA, ISB-Swedish COVID19 Biobanking Unit, Wei W, Price ND, Huang S, Subramanian N, Wang K, Magis AT, Hadlock JJ, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg PD, Gottardo R, Davis MM, Goldman JD, Heath JR. PMID: 33171100; PMCID: PMC7598382.
      View in: PubMed   Mentions: 315     Fields:    Translation:HumansCellsCTClinical Trials
    21. Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis. Sci Immunol. 2020 10 02; 5(52). Lee JC, Mehdizadeh S, Smith J, Young A, Mufazalov IA, Mowery CT, Daud A, Bluestone JA. PMID: 33008914; PMCID: PMC7755924.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    22. Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes. Cell Stem Cell. 2020 10 01; 27(4):505-507. Bluestone JA, Tang Q. PMID: 33007232.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nat Immunol. 2020 11; 21(11):1456-1466. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. PMID: 32989329; PMCID: PMC7577958.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    24. Tolerance in the Age of Immunotherapy. N Engl J Med. 2020 09 17; 383(12):1156-1166. Bluestone JA, Anderson M. PMID: 32937048; PMCID: PMC7534289.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    25. Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories. bioRxiv. 2020 Jul 31. Su Y, Chen D, Lausted C, Yuan D, Choi J, Dai C, Voillet V, Scherler K, Troisch P, Duvvuri VR, Baloni P, Qin G, Smith B, Kornilov S, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Jones L, Zhou Y, Roper R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Michael ZA, Magis A, Wei W, Price ND, Huang S, Subramanian N, Wang K, Hadlock J, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg P, Gottardo R, Davis MM, Goldman JD, Heath JR. PMID: 32766585; PMCID: PMC7402042.
      View in: PubMed   Mentions: 1  
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    63. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; 25(5):1207. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28467938.
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    69. Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016 05 01; 196(9):3966. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF. PMID: 27183651.
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    77. Shifting the Evolving CAR T Cell Platform into Higher Gear. Cancer Cell. 2015 Oct 12; 28(4):401-402. Holohan DR, Lee JC, Bluestone JA. PMID: 26461084.
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    249. Insulin secretion in type 1 diabetes. Diabetes. 2004 Feb; 53(2):426-33. Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC. PMID: 14747294.
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    257. Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis. J Clin Invest. 2003 Jun; 111(12):1923-31. Ding W, Beissert S, Deng L, Miranda E, Cassetty C, Seiffert K, Campton KL, Yan Z, Murphy GF, Bluestone JA, Granstein RD. PMID: 12813028; PMCID: PMC161417.
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    263. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003 Jan 06; 197(1):129-35. Chikuma S, Imboden JB, Bluestone JA. PMID: 12515820; PMCID: PMC2193802.
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    269. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J Rheumatol. 2002 Sep; 29(9):1907-13. Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. PMID: 12233885.
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    309. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol. 1999 May 15; 162(10):5784-91. Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. PMID: 10229811.
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    310. Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4. Cancer Res. 1999 May 01; 59(9):2096-101. Richards J, Auger J, Peace D, Gale D, Michel J, Koons A, Haverty T, Zivin R, Jolliffe L, Bluestone JA. PMID: 10232594.
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    311. Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism. J Immunol. 1999 Apr 15; 162(8):4817-23. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. PMID: 10202025.
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    312. CD2 and CD3 receptor-mediated tolerance: constraints on T cell activation. Transplantation. 1999 Mar 15; 67(5):741-8. Punch JD, Lin J, Bluestone J, Bromberg JS. PMID: 10096532.
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    313. TCRgammadelta cells and viruses. Microbes Infect. 1999 Mar; 1(3):203-12. Sciammas R, Bluestone JA. PMID: 10801231.
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    314. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol. 1999 Feb 01; 162(3):1270-7. Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB. PMID: 9973379.
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    315. Activation and peripheral expansion of murine T-cell receptor gamma delta intraepithelial lymphocytes. Gastroenterology. 1999 Feb; 116(2):327-34. Guehler SR, Bluestone JA, Barrett TA. PMID: 9922313.
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    316. The CTLA-4 gene is expressed in placental fibroblasts. Mol Hum Reprod. 1999 Jan; 5(1):84-7. Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C. PMID: 10050667.
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    317. Molecular basis of T cell inactivation by CTLA-4. Science. 1998 Dec 18; 282(5397):2263-6. Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA. PMID: 9856951.
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    318. Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells. J Immunol. 1998 Dec 15; 161(12):6552-8. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. PMID: 9862681.
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    319. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res. 1998 Dec 01; 58(23):5301-4. Mokyr MB, Kalinichenko T, Gorelik L, Bluestone JA. PMID: 9850053.
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    320. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. J Immunol. 1998 Nov 15; 161(10):5187-92. Sciammas R, Bluestone JA. PMID: 9820489.
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    321. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol. 1998 Nov 15; 161(10):5138-42. Salomon B, Bluestone JA. PMID: 9820482.
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    322. Signalling through the TCR. Res Immunol. 1998 Nov-Dec; 149(9):866-7. Cantrell D, Bluestone J, Vivier E, Tybulewicz V. PMID: 9923642.
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    323. Cell fate in the immune system: decisions, decisions, decisions. Immunol Rev. 1998 Oct; 165:5-12. Bluestone JA. PMID: 9850847.
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    324. Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease. J Neuroimmunol. 1998 Aug 14; 89(1-2):10-8. Karandikar NJ, Vanderlugt CL, Bluestone JA, Miller SD. PMID: 9726820.
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    325. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol. 1998 Aug 01; 161(3):1516-24. Ma Y, Thornton S, Duwel LE, Boivin GP, Giannini EH, Leiden JM, Bluestone JA, Hirsch R. PMID: 9686619.
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    326. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunol Rev. 1998 Aug; 164:63-72. Vanderlugt CL, Begolka WS, Neville KL, Katz-Levy Y, Howard LM, Eagar TN, Bluestone JA, Miller SD. PMID: 9795764.
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    327. Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. J Immunol. 1998 Jul 01; 161(1):192-9. Karandikar NJ, Vanderlugt CL, Eagar T, Tan L, Bluestone JA, Miller SD. PMID: 9647224.
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    328. Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience. Transplant Proc. 1998 Jun; 30(4):1369-70. Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR. PMID: 9636555.
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    329. Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes. J Immunol. 1998 Jun 01; 160(11):5341-6. Guehler SR, Finch RJ, Bluestone JA, Barrett TA. PMID: 9605133.
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    330. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J Exp Med. 1998 May 18; 187(10):1699-709. Chau LA, Bluestone JA, Madrenas J. PMID: 9584148; PMCID: PMC2212283.
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    331. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol. 1998 May 15; 160(10):4841-9. Smith JA, Tang Q, Bluestone JA. PMID: 9590231.
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    332. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J Immunol. 1998 Apr 15; 160(8):3855-60. Walunas TL, Bluestone JA. PMID: 9558090.
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    333. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):453-62. Padrid PA, Mathur M, Li X, Herrmann K, Qin Y, Cattamanchi A, Weinstock J, Elliott D, Sperling AI, Bluestone JA. PMID: 9533932.
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    334. Importance of the B7-2 molecule for low dose melphalan-induced acquisition of tumor-eradicating immunity by mice bearing a large MOPC-315 tumor. J Immunol. 1998 Feb 15; 160(4):1866-74. Mokyr MB, Kalinichenko TV, Gorelik L, Bluestone JA. PMID: 9469448.
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    335. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol. 1997 Dec 01; 159(11):5187-91. Levisetti MG, Padrid PA, Szot GL, Mittal N, Meehan SM, Wardrip CL, Gray GS, Bruce DS, Thistlethwaite JR, Bluestone JA. PMID: 9548454.
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    336. Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE. J Neuroimmunol. 1997 Nov; 79(2):113-8. Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD. PMID: 9394783.
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    337. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol. 1997 Nov 01; 159(9):4150-3. Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA. PMID: 9379007.
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    338. Transplantation tolerance--putting the pieces together. Curr Opin Immunol. 1997 Oct; 9(5):631-3. Lechler R, Bluestone JA. PMID: 9368770.
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    339. T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. Curr Opin Immunol. 1997 Oct; 9(5):648-54. Smith JA, Bluestone JA. PMID: 9368773.
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    340. Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res. 1997 Sep 15; 57(18):4036-41. Yang YF, Zou JP, Mu J, Wijesuriya R, Ono S, Walunas T, Bluestone J, Fujiwara H, Hamaoka T. PMID: 9307290.
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    341. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med. 1997 Jul 21; 186(2):229-38. Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H. PMID: 9221752; PMCID: PMC2198977.
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    342. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. J Immunol. 1997 Jul 01; 159(1):86-91. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. PMID: 9200442.
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    343. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. PMID: 9166426; PMCID: PMC2196341.
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    344. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J Exp Med. 1997 Apr 21; 185(8):1413-22. Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA. PMID: 9126922; PMCID: PMC2196281.
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    345. Is CTLA-4 a master switch for peripheral T cell tolerance? J Immunol. 1997 Mar 01; 158(5):1989-93. Bluestone JA. PMID: 9036940.
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    346. Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J Immunol. 1997 Mar 01; 158(5):2156-64. Woodle ES, Smith DM, Bluestone JA, Kirkman WM, Green DR, Skowronski EW. PMID: 9036961.
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    347. CD28/B7 regulation of autoimmune diabetes. Immunol Res. 1997 Feb; 16(1):71-84. Herold KG, Lenschow DJ, Bluestone JA. PMID: 9048209.
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    348. Class I MHC mediates programmed cell death in a Fas-independent manner. Transplant Proc. 1997 Feb-Mar; 29(1-2):1101. Woodle ES, Smith DM, Bluestone JA, Green DR, Skowronski EW. PMID: 9123218.
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    349. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med. 1997 Jan 20; 185(2):219-29. Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. PMID: 9016871; PMCID: PMC2196122.
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    350. CD28 costimulation promotes the production of Th2 cytokines. J Immunol. 1997 Jan 15; 158(2):658-65. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. PMID: 8992981.
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    351. CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. J Immunol. 1997 Jan 15; 158(2):984-91. Herold KC, Vezys V, Koons A, Lenschow D, Thompson C, Bluestone JA. PMID: 8993020.
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    352. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J Immunol. 1996 Nov 01; 157(9):3909-17. Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA. PMID: 8892622.
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    353. The complexities of T-cell co-stimulation: CD28 and beyond. Immunol Rev. 1996 Oct; 153:155-82. Sperling AI, Bluestone JA. PMID: 9010723.
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    354. TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen. J Immunol. 1996 Sep 15; 157(6):2320-7. Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA. PMID: 8805629.
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    355. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 1996 Sep; 5(3):285-93. Lenschow DJ, Herold KC, Rhee L, Patel B, Koons A, Qin HY, Fuchs E, Singh B, Thompson CB, Bluestone JA. PMID: 8808683.
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    356. Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts. J Exp Med. 1996 Aug 01; 184(2):493-503. Guehler SR, Bluestone JA, Barrett TA. PMID: 8760803; PMCID: PMC2192706.
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    357. CTLA-4: a negative regulator of autoimmune disease. J Exp Med. 1996 Aug 01; 184(2):783-8. Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA. PMID: 8760834; PMCID: PMC2192746.
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    358. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med. 1996 Jun 01; 183(6):2541-50. Walunas TL, Bakker CY, Bluestone JA. PMID: 8676075; PMCID: PMC2192609.
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    359. Regulation of CTLA-4 expression during T cell activation. J Immunol. 1996 Jun 01; 156(11):4154-9. Perkins D, Wang Z, Donovan C, He H, Mark D, Guan G, Wang Y, Walunas T, Bluestone J, Listman J, Finn PW. PMID: 8666782.
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    360. Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens. Blood. 1996 May 15; 87(10):4463-72. Blazar BR, Taylor PA, Bluestone JA, Vallera DA. PMID: 8639809.
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    361. In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells. Transplantation. 1996 Mar 15; 61(5):798-803. Woodle ES, Hussein S, Bluestone JA. PMID: 8607186.
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    362. Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule. Cancer Immunol Immunother. 1996 Mar; 42(3):161-9. La Motte RN, Rubin MA, Barr E, Leiden JM, Bluestone JA, Mokyr MB. PMID: 8640844; PMCID: PMC11037802.
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    363. Costimulation and its role in organ transplantation. Clin Transplant. 1996 Feb; 10(1 Pt 2):104-9. Bluestone JA. PMID: 8680045.
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    364. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol. 1996 Feb 01; 156(3):1006-13. Walunas TL, Sperling AI, Khattri R, Thompson CB, Bluestone JA. PMID: 8557973.
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    365. IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. J Immunol. 1996 Jan 15; 156(2):663-9. Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y. PMID: 8543818.
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    366. Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens. Blood. 1996 Jan 15; 87(2):827-37. Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Barrett TA, Bluestone JA, Vallera DA. PMID: 8555509.
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    367. CD28/B7 system of T cell costimulation. Annu Rev Immunol. 1996; 14:233-58. Lenschow DJ, Walunas TL, Bluestone JA. PMID: 8717514.
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    368. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity. 1995 Dec; 3(6):739-45. Miller SD, Vanderlugt CL, Lenschow DJ, Pope JG, Karandikar NJ, Dal Canto MC, Bluestone JA. PMID: 8777719.
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    369. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies. Transplantation. 1995 Nov 27; 60(10):1171-8. Lenschow DJ, Zeng Y, Hathcock KS, Zuckerman LA, Freeman G, Thistlethwaite JR, Gray GS, Hodes RJ, Bluestone JA. PMID: 7482727.
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    370. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995 Nov; 3(5):541-7. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. PMID: 7584144.
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    371. Development of TCR gamma delta iIELs. Semin Immunol. 1995 Oct; 7(5):299-305. Barrett TA, Bluestone JA. PMID: 8580462.
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    372. Transplantation. Curr Opin Immunol. 1995 Oct; 7(5):617-9. Bluestone JA, Lechler RI. PMID: 8573302.
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    373. Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent. J Immunol. 1995 Sep 01; 155(5):2379-86. Kaliyaperumal A, Falchetto R, Cox A, Dick R, Shabanowitz J, Chien YH, Matis L, Hunt DF, Bluestone JA. PMID: 7650372.
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    374. Ly-6C is a marker of memory CD8+ T cells. J Immunol. 1995 Aug 15; 155(4):1873-83. Walunas TL, Bruce DS, Dustin L, Loh DY, Bluestone JA. PMID: 7543536.
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    375. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol. 1995 Aug 01; 155(3):1544-55. Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA. PMID: 7636216.
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    376. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol. 1995 Aug 01; 155(3):1032-6. Kearney ER, Walunas TL, Karr RW, Morton PA, Loh DY, Bluestone JA, Jenkins MK. PMID: 7543510.
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    377. Two waves of gamma delta T cells expressing different V delta genes are recruited into schistosome-induced liver granulomas. J Immunol. 1995 Jul 01; 155(1):275-84. Sandor M, Sperling AI, Cook GA, Weinstock JV, Lynch RG, Bluestone JA. PMID: 7602105.
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    378. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995 Jul 01; 182(1):139-46. Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB. PMID: 7790813; PMCID: PMC2192086.
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    379. New perspectives of CD28-B7-mediated T cell costimulation. Immunity. 1995 Jun; 2(6):555-9. Bluestone JA. PMID: 7540940.
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    380. T cell costimulation through the CD28 receptor. Proc Assoc Am Physicians. 1995 Apr; 107(1):41-6. Green JM, Noel PJ, Sperling AI, Walunas TL, Lenschow DJ, Stack R, Gray GS, Bluestone JA, Thompson CB. PMID: 8630743.
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    381. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med. 1995 Mar 01; 181(3):1145-55. Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA. PMID: 7532678; PMCID: PMC2191918.
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    382. Inhibition of T-cell activation by an anti-human class I MHC reactive monoclonal antibody occurs at a point distal to TCR-CD3 mediated signal transduction. Transplant Proc. 1995 Feb; 27(1):395-7. Smith DM, Bluestone JA, Thistlethwaite JR, Woodle ES. PMID: 7879035.
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    383. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27; 270(4):1928-34. Hu Q, Davidson D, Schwartzberg PL, Macchiarini F, Lenardo MJ, Bluestone JA, Matis LA. PMID: 7829530.
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    384. Programmed differentiation of murine thymocytes during fetal thymus organ culture. J Immunol Methods. 1995 Jan 13; 178(1):13-29. DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. PMID: 7829862.
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    385. Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors. Dig Dis Sci. 1995 Jan; 40(1):58-64. Alegre ML, Lenschow DJ, Bluestone JA. PMID: 7821120.
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    386. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol. 1995; 11:307-53. Bluestone JA, Khattri R, Sciammas R, Sperling AI. PMID: 8689560.
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    387. Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication. J Immunol. 1994 Oct 01; 153(7):3123-34. Mokyr MB, Prokhorova A, Rubin M, Bluestone JA. PMID: 8089490.
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    388. Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies. Transplantation. 1994 Sep 27; 58(6):681-9. Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA. PMID: 7940687.
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    389. Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol. 1994 Sep 15; 153(6):2738-49. Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR. PMID: 8077678.
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    390. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol. 1994 Sep 01; 153(5):1990-7. Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA. PMID: 7519638.
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    391. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1994 Sep; 1(6):501-8. Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, Thompson CB. PMID: 7534617.
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    392. Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules. J Immunol. 1994 Aug 01; 153(3):1054-67. Smith DM, Bluestone JA, Jeyarajah DR, Newberg MH, Engelhard VH, Thistlethwaite JR, Woodle ES. PMID: 7913109.
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    393. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994 Aug; 1(5):405-13. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. PMID: 7882171.
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    394. The B7 and CD28 receptor families. Immunol Today. 1994 Jul; 15(7):321-31. June CH, Bluestone JA, Nadler LM, Thompson CB. PMID: 7522010.
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    395. Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model. Transplantation. 1994 Jun 27; 57(12):1786-94. Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA. PMID: 8016885.
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    396. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 1994 Jun 15; 57(11):1537-43. Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. PMID: 8009586.
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    397. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J Immunol. 1994 Jun 15; 152(12):5723-33. Stack RM, Lenschow DJ, Gray GS, Bluestone JA, Fitch FW. PMID: 7515912.
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    398. Prolongation of human pancreatic islet xenografts by pretreatment of islets with anti-human ICAM-1 monoclonal antibody. Transplant Proc. 1994 Jun; 26(3):1120. Zeng Y, Torres MA, Thistlethwaite JR, Montag A, Bluestone JA. PMID: 7913254.
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    399. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol. 1994 Jun 01; 152(11):5392-7. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA. PMID: 8189058.
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    400. Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases. J Immunol. 1994 Apr 01; 152(7):3522-9. Rubin M, Bluestone JA, Newell KA, Prokhorova A, Mokyr MB. PMID: 8144932.
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    401. The nature of major histocompatibility complex recognition by gamma delta T cells. Cell. 1994 Jan 14; 76(1):29-37. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH. PMID: 8287478.
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    402. TCR gamma delta cells: mysterious cells of the immune system. Immunol Res. 1994; 13(4):268-79. Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA. PMID: 7616054.
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    403. Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture. Thymus. 1994-1995; 23(3-4):131-53. Tatsumi Y, Deluca D, Cron RQ, Bluestone JA. PMID: 8525502.
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    404. The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11875-9. Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, Fitch FW. PMID: 8265641; PMCID: PMC48087.
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    405. Role of gamma delta T cells in murine collagen-induced arthritis. J Immunol. 1993 Dec 01; 151(11):6546-58. Peterman GM, Spencer C, Sperling AI, Bluestone JA. PMID: 8245484.
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    406. T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas. Cell Immunol. 1993 Dec; 152(2):305-22. Sydora BC, Mixter PF, Houlden B, Hershberg R, Levy R, Comay M, Bluestone J, Kronenberg M. PMID: 8258140.
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    407. CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes. J Immunol. 1993 Dec 01; 151(11):6043-50. Sperling AI, Linsley PS, Barrett TA, Bluestone JA. PMID: 8245449.
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    408. Expression and functional significance of an additional ligand for CTLA-4. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11054-8. Lenschow DJ, Su GH, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miller J, Bluestone JA. PMID: 7504292; PMCID: PMC47920.
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    409. Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan. J Immunol. 1993 Nov 01; 151(9):4838-46. Mokyr MB, Rubin M, Newell KA, Prokhorova A, Bluestone JA. PMID: 8409442.
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    410. Peptide-induced changes in class I heavy chains alter allorecognition. J Immunol. 1993 Oct 15; 151(8):3943-53. Bluestone JA, Kaliyaperumal A, Jameson S, Miller S, Dick R. PMID: 8409378.
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    411. Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes. Eur J Immunol. 1993 Oct; 23(10):2482-7. Dent AL, Matis LA, Bluestone JA, Hedrick SM. PMID: 8405049.
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    412. T cell co-stimulation and in vivo tolerance. Curr Opin Immunol. 1993 Oct; 5(5):747-52. Lenschow DJ, Bluestone JA. PMID: 7694594.
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    413. Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation. J Immunol. 1993 Sep 15; 151(6):3030-41. Tatsumi Y, Pena JC, Matis L, Deluca D, Bluestone JA. PMID: 8376767.
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    414. Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):6949-51. Sherman LA, Chattopadhyay S, Biggs JA, Dick RF, Bluestone JA. PMID: 8346201; PMCID: PMC47052.
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    415. Tolerance of T cell receptor gamma/delta cells in the intestine. J Exp Med. 1993 Jun 01; 177(6):1755-62. Barrett TA, Tatsumi Y, Bluestone JA. PMID: 8098732; PMCID: PMC2191050.
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    416. Non-classical MHC molecules: the first line of defence? Curr Biol. 1993 May 01; 3(5):294-6. Sperling AI, Bluestone JA. PMID: 15335753.
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    417. Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. J Exp Med. 1993 Apr 01; 177(4):1061-70. Wells FB, Tatsumi Y, Bluestone JA, Hedrick SM, Allison JP, Matis LA. PMID: 8459203; PMCID: PMC2190965.
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    418. Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat-->B6 mouse). Transplant Proc. 1993 Feb; 25(1 Pt 1):438-9. Zeng Y, Bluestone JA, Ildstad ST, Torres MA, Montag AG, Thistlethwaite RJ. PMID: 8438368.
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    419. Immunosuppressive effects of anti-CD3 MAb and soluble co-stimulatory molecules. Transplant Proc. 1993 Feb; 25(1 Pt 1):546-7. Bluestone JA, Bruce D, Peterson L, Thistlethwaite JR, Josephson M, Zeng Y, Linsley PS, Lenschow DJ. PMID: 8438407.
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    420. Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier. J Immunol. 1993 Jan 01; 150(1):265-77. Blazar BR, Taylor PA, Snover DC, Bluestone JA, Vallera DA. PMID: 8417127.
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    421. Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition. J Exp Med. 1992 Dec 01; 176(6):1757-61. Bluestone JA, Jameson S, Miller S, Dick R. PMID: 1460430; PMCID: PMC2119441.
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    422. Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection. J Immunol. 1992 Nov 15; 149(10):3200-7. Sperling AI, Cron RQ, Decker DC, Stern DA, Bluestone JA. PMID: 1431099.
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    423. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol. 1992 Aug 15; 149(4):1124-30. Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. PMID: 1380032.
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    424. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science. 1992 Aug 07; 257(5071):789-92. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA. PMID: 1323143.
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    425. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8. Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA. PMID: 1534096.
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    426. Effects of anti-CD3 monoclonal antibody on engraftment of T-cell-depleted bone marrow allografts in mice: host T-cell suppression, growth factors, and space. Blood. 1992 Jun 01; 79(11):3050-8. Hiruma K, Hirsch R, Patchen M, Bluestone JA, Gress RE. PMID: 1534027.
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    427. Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression. J Immunol. 1992 May 01; 148(9):2756-63. Woodle ES, Thistlethwaite JR, Jolliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA. PMID: 1533410.
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    428. In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors. J Immunol. 1992 Apr 15; 148(8):2363-9. Sandor M, Houlden B, Bluestone J, Hedrick SM, Weinstock J, Lynch RG. PMID: 1532812.
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    429. The T cell receptor in autoimmune diseases. J Rheumatol Suppl. 1992 Apr; 33:75-7. Bluestone JA, Spencer C, Hirsch R. PMID: 1534379.
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