Jacob Ayers • UCSF Profiles

Jacob Ayers, PhD

Title(s)	Associate Professor, Institute for Neurodegenerative Diseases
School	School of Medicine
Address	675 Nelson Rising Lane, #315C San Francisco CA 94158
Phone	--
ORCID	0000-0003-4544-2366
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Other Positions


Title(s)	UCSF Weill Institute for Neurosciences

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice. Viruses. 2023 08 26; 15(9). Ayers JI, Xu G, Lu Q, Dillon K, Fromholt S, Borchelt DR. PMID: 37766226; PMCID: PMC10534885.

View in: PubMed Mentions: Fields:
Vir Virology
Translation:Humans Animals
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2220984120. Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB. PMID: 36952379; PMCID: PMC10068802.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Humans
Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics. Nat Mach Intell. 2022 Jun; 4(6):583-595. Wong DR, Conrad J, Johnson N, Ayers J, Laeremans A, Lee JC, Lee J, Prusiner SB, Bandyopadhyay S, Butte AJ, Paras NA, Keiser MJ. PMID: 36276634; PMCID: PMC9585544.

View in: PubMed Mentions: 5
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB. PMID: 35115402; PMCID: PMC8833220.

View in: PubMed Mentions: 23 Fields:
Sci Science
Translation:Humans Cells
Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence. Acta Neuropathol Commun. 2021 05 20; 9(1):92. Ayers JI, Xu G, Dillon K, Lu Q, Chen Z, Beckman J, Moreno-Romero AK, Zamora DL, Galaleldeen A, Borchelt DR. PMID: 34016165; PMCID: PMC8139116.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Humans Animals Cells
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021 05 19; 109(10):1675-1691.e9. Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R. PMID: 33848474; PMCID: PMC8141031.

View in: PubMed Mentions: 61 Fields:
Neu Neurology
Translation:Humans Animals Cells
Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates. Neurosci Lett. 2021 01 18; 742:135553. Xia Y, Chen Z, Xu G, Borchelt DR, Ayers JI, Giasson BI. PMID: 33346076; PMCID: PMC9171709.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Humans Animals Cells
Phenotypic diversity in ALS and the role of poly-conformational protein misfolding. Acta Neuropathol. 2021 07; 142(1):41-55. Ayers JI, Borchelt DR. PMID: 32930869; PMCID: PMC7956917.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Humans Animals Cells
Expanding spectrum of prion diseases. Emerg Top Life Sci. 2020 09 08; 4(2):155-167. Ayers JI, Paras NA, Prusiner SB. PMID: 32803268.

View in: PubMed Mentions: 18 Fields:
Bio Biology
Translation:Humans Animals Cells
Prion protein - mediator of toxicity in multiple proteinopathies. Nat Rev Neurol. 2020 04; 16(4):187-188. Ayers JI, Prusiner SB. PMID: 32123368.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection. PLoS One. 2020; 15(1):e0227655. Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI. PMID: 31999698; PMCID: PMC6991973.

View in: PubMed Mentions: 11 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals
ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. iScience. 2019 Sep 27; 19:448-449. Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. PMID: 31425915; PMCID: PMC6708981.

View in: PubMed Mentions: 6
Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis. G3 (Bethesda). 2019 03 07; 9(3):719-728. Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR. PMID: 30622123; PMCID: PMC6404617.

View in: PubMed Mentions: 3 Fields:
Gen Genetics Mol Molecular Biology
Translation:Humans Animals Cells
ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. iScience. 2019 Jan 25; 11:294-304. Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. PMID: 30639851; PMCID: PMC6327879.

View in: PubMed Mentions: 12
Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models. PLoS One. 2018; 13(11):e0206751. Crosby K, Crown AM, Roberts BL, Brown H, Ayers JI, Borchelt DR. PMID: 30399166; PMCID: PMC6219784.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts. J Virol. 2018 09 15; 92(18). Ayers JI, Riffe CJ, Sorrentino ZA, Diamond J, Fagerli E, Brooks M, Galaleldeen A, Hart PJ, Giasson BI. PMID: 29976670; PMCID: PMC6146706.

View in: PubMed Mentions: 17 Fields:
Vir Virology
Translation:Humans Animals Cells
Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces. Colloids Surf B Biointerfaces. 2018 Jun 01; 166:98-107. Phan HTM, Bartz JC, Ayers J, Giasson BI, Schubert M, Rodenhausen KB, Kananizadeh N, Li Y, Bartelt-Hunt SL. PMID: 29550546; PMCID: PMC5911191.

View in: PubMed Mentions: 2 Fields:
Che Chemistry
Translation:Cells
Prion-like mechanisms in amyotrophic lateral sclerosis. Handb Clin Neurol. 2018; 153:337-354. Ayers JI, Cashman NR. PMID: 29887144.

View in: PubMed Mentions: 21 Fields:
Neu Neurology
Translation:Humans
Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding. J Biol Chem. 2017 11 24; 292(47):19366-19380. Rasouli S, Abdolvahabi A, Croom CM, Plewman DL, Shi Y, Ayers JI, Shaw BF. PMID: 28974578; PMCID: PMC5702675.

View in: PubMed Mentions: 14 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Prion-like Spreading in Tauopathies. Biol Psychiatry. 2018 02 15; 83(4):337-346. Ayers JI, Giasson BI, Borchelt DR. PMID: 28506438; PMCID: PMC5640465.

View in: PubMed Mentions: 45 Fields:
Psy Psychiatry Psy Psychophysiology
Translation:Humans Animals
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils. J Virol. 2017 Jan 15; 91(2). Ayers JI, Brooks MM, Rutherford NJ, Howard JK, Sorrentino ZA, Riffe CJ, Giasson BI. PMID: 27852849; PMCID: PMC5215322.

View in: PubMed Mentions: 44 Fields:
Vir Virology
Translation:Animals Cells
Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models. J Neurochem. 2017 01; 140(1):140-150. Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR. PMID: 27727458; PMCID: PMC5283795.

View in: PubMed Mentions: 9 Fields:
Che Chemistry Neu Neurology
Translation:Humans Animals Cells
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS. Acta Neuropathol. 2016 12; 132(6):827-840. Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR. PMID: 27704280; PMCID: PMC5107152.

View in: PubMed Mentions: 24 Fields:
Neu Neurology
Translation:Humans Animals Cells
Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice. J Virol. 2016 09 15; 90(18):8293-301. Kincaid AE, Ayers JI, Bartz JC. PMID: 27384659; PMCID: PMC5008084.

View in: PubMed Mentions: 8 Fields:
Vir Virology
Translation:Animals
Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways. Acta Neuropathol. 2016 Jan; 131(1):103-14. Ayers JI, Fromholt SE, O'Neal VM, Diamond JH, Borchelt DR. PMID: 26650262; PMCID: PMC4699876.

View in: PubMed Mentions: 72 Fields:
Neu Neurology
Translation:Animals Cells
Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathol. 2016 Jan; 131(1):151-4. Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. PMID: 26541429; PMCID: PMC4852859.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Humans Animals
Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. J Neurochem. 2015 May; 133(3):452-64. Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. PMID: 25557022; PMCID: PMC4397187.

View in: PubMed Mentions: 8 Fields:
Che Chemistry Neu Neurology
Translation:Humans Animals Cells
Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. Hum Mol Genet. 2015 Feb 15; 24(4):1019-35. Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. PMID: 25305079; PMCID: PMC4375410.

View in: PubMed Mentions: 7 Fields:
Gen Genetics Mol Molecular Biology
Translation:Humans Animals Cells
Experimental transmissibility of mutant SOD1 motor neuron disease. Acta Neuropathol. 2014 Dec; 128(6):791-803. Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR. PMID: 25262000.

View in: PubMed Mentions: 58 Fields:
Neu Neurology
Translation:Animals Cells
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice. Mol Ther. 2015 Jan; 23(1):53-62. Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. PMID: 25228069; PMCID: PMC4426802.

View in: PubMed Mentions: 35 Fields:
Mol Molecular Biology The Therapeutics
Translation:Humans Animals Cells
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10732-7. Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. PMID: 25002524; PMCID: PMC4115570.

View in: PubMed Mentions: 176 Fields:
Sci Science
Translation:Humans Animals
Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases. Acta Neuropathol Commun. 2014 May 14; 2:55. Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR. PMID: 24887207; PMCID: PMC4035506.

View in: PubMed Mentions: 27 Fields:
Neu Neurology
Translation:Humans Animals Cells
Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease. J Neurochem. 2014 Jan; 128(2):305-14. Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. PMID: 24032979; PMCID: PMC3971632.

View in: PubMed Mentions: 12 Fields:
Che Chemistry Neu Neurology
Translation:Humans Cells
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. PLoS Pathog. 2011 Mar; 7(3):e1001317. Ayers JI, Schutt CR, Shikiya RA, Aguzzi A, Kincaid AE, Bartz JC. PMID: 21437239; PMCID: PMC3060105.

View in: PubMed Mentions: 84 Fields:
Mic Microbiology
Translation:Animals Cells PHPublic Health
Coinfecting prion strains compete for a limiting cellular resource. J Virol. 2010 Jun; 84(11):5706-14. Shikiya RA, Ayers JI, Schutt CR, Kincaid AE, Bartz JC. PMID: 20237082; PMCID: PMC2876617.

View in: PubMed Mentions: 58 Fields:
Vir Virology
Translation:Animals Cells
Prion strain targeting independent of strain-specific neuronal tropism. J Virol. 2009 Jan; 83(1):81-7. Ayers JI, Kincaid AE, Bartz JC. PMID: 18971281; PMCID: PMC2612296.

View in: PubMed Mentions: 27 Fields:
Vir Virology
Translation:Humans Animals Cells
Prion interference is due to a reduction in strain-specific PrPSc levels. J Virol. 2007 Jan; 81(2):689-97. Bartz JC, Kramer ML, Sheehan MH, Hutter JA, Ayers JI, Bessen RA, Kincaid AE. PMID: 17079313; PMCID: PMC1797475.

View in: PubMed Mentions: 46 Fields:
Vir Virology
Translation:Animals