Jacob Ayers, PhD

Title(s)Associate Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #315C
San Francisco CA 94158
ORCID ORCID Icon0000-0003-4544-2366 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice. Viruses. 2023 08 26; 15(9). Ayers JI, Xu G, Lu Q, Dillon K, Fromholt S, Borchelt DR. PMID: 37766226; PMCID: PMC10534885.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2220984120. Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB. PMID: 36952379; PMCID: PMC10068802.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    3. Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics. Nat Mach Intell. 2022 Jun; 4(6):583-595. Wong DR, Conrad J, Johnson N, Ayers J, Laeremans A, Lee JC, Lee J, Prusiner SB, Bandyopadhyay S, Butte AJ, Paras NA, Keiser MJ. PMID: 36276634; PMCID: PMC9585544.
      View in: PubMed   Mentions: 5  
    4. Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB. PMID: 35115402; PMCID: PMC8833220.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    5. Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence. Acta Neuropathol Commun. 2021 05 20; 9(1):92. Ayers JI, Xu G, Dillon K, Lu Q, Chen Z, Beckman J, Moreno-Romero AK, Zamora DL, Galaleldeen A, Borchelt DR. PMID: 34016165; PMCID: PMC8139116.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021 05 19; 109(10):1675-1691.e9. Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R. PMID: 33848474; PMCID: PMC8141031.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    7. Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates. Neurosci Lett. 2021 01 18; 742:135553. Xia Y, Chen Z, Xu G, Borchelt DR, Ayers JI, Giasson BI. PMID: 33346076; PMCID: PMC9171709.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Phenotypic diversity in ALS and the role of poly-conformational protein misfolding. Acta Neuropathol. 2021 07; 142(1):41-55. Ayers JI, Borchelt DR. PMID: 32930869; PMCID: PMC7956917.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Expanding spectrum of prion diseases. Emerg Top Life Sci. 2020 09 08; 4(2):155-167. Ayers JI, Paras NA, Prusiner SB. PMID: 32803268.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    10. Prion protein - mediator of toxicity in multiple proteinopathies. Nat Rev Neurol. 2020 04; 16(4):187-188. Ayers JI, Prusiner SB. PMID: 32123368.
      View in: PubMed   Mentions: 1     Fields:    
    11. Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection. PLoS One. 2020; 15(1):e0227655. Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI. PMID: 31999698; PMCID: PMC6991973.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    12. ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. iScience. 2019 Sep 27; 19:448-449. Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. PMID: 31425915; PMCID: PMC6708981.
      View in: PubMed   Mentions: 4  
    13. Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis. G3 (Bethesda). 2019 03 07; 9(3):719-728. Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR. PMID: 30622123; PMCID: PMC6404617.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. iScience. 2019 Jan 25; 11:294-304. Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. PMID: 30639851; PMCID: PMC6327879.
      View in: PubMed   Mentions: 15  
    15. Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models. PLoS One. 2018; 13(11):e0206751. Crosby K, Crown AM, Roberts BL, Brown H, Ayers JI, Borchelt DR. PMID: 30399166; PMCID: PMC6219784.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts. J Virol. 2018 09 15; 92(18). Ayers JI, Riffe CJ, Sorrentino ZA, Diamond J, Fagerli E, Brooks M, Galaleldeen A, Hart PJ, Giasson BI. PMID: 29976670; PMCID: PMC6146706.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    17. Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces. Colloids Surf B Biointerfaces. 2018 Jun 01; 166:98-107. Phan HTM, Bartz JC, Ayers J, Giasson BI, Schubert M, Rodenhausen KB, Kananizadeh N, Li Y, Bartelt-Hunt SL. PMID: 29550546; PMCID: PMC5911191.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    18. Prion-like mechanisms in amyotrophic lateral sclerosis. Handb Clin Neurol. 2018; 153:337-354. Ayers JI, Cashman NR. PMID: 29887144.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    19. Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding. J Biol Chem. 2017 11 24; 292(47):19366-19380. Rasouli S, Abdolvahabi A, Croom CM, Plewman DL, Shi Y, Ayers JI, Shaw BF. PMID: 28974578; PMCID: PMC5702675.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Prion-like Spreading in Tauopathies. Biol Psychiatry. 2018 02 15; 83(4):337-346. Ayers JI, Giasson BI, Borchelt DR. PMID: 28506438; PMCID: PMC5640465.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    21. Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils. J Virol. 2017 Jan 15; 91(2). Ayers JI, Brooks MM, Rutherford NJ, Howard JK, Sorrentino ZA, Riffe CJ, Giasson BI. PMID: 27852849; PMCID: PMC5215322.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    22. Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models. J Neurochem. 2017 01; 140(1):140-150. Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR. PMID: 27727458; PMCID: PMC5283795.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS. Acta Neuropathol. 2016 12; 132(6):827-840. Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR. PMID: 27704280; PMCID: PMC5107152.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    24. Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice. J Virol. 2016 09 15; 90(18):8293-301. Kincaid AE, Ayers JI, Bartz JC. PMID: 27384659; PMCID: PMC5008084.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    25. Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways. Acta Neuropathol. 2016 Jan; 131(1):103-14. Ayers JI, Fromholt SE, O'Neal VM, Diamond JH, Borchelt DR. PMID: 26650262; PMCID: PMC4699876.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    26. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathol. 2016 Jan; 131(1):151-4. Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. PMID: 26541429; PMCID: PMC4852859.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    27. Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. J Neurochem. 2015 May; 133(3):452-64. Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. PMID: 25557022; PMCID: PMC4397187.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. Hum Mol Genet. 2015 Feb 15; 24(4):1019-35. Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. PMID: 25305079; PMCID: PMC4375410.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Experimental transmissibility of mutant SOD1 motor neuron disease. Acta Neuropathol. 2014 Dec; 128(6):791-803. Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR. PMID: 25262000.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    30. Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice. Mol Ther. 2015 Jan; 23(1):53-62. Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. PMID: 25228069; PMCID: PMC4426802.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    31. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10732-7. Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. PMID: 25002524; PMCID: PMC4115570.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimals
    32. Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases. Acta Neuropathol Commun. 2014 May 14; 2:55. Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR. PMID: 24887207; PMCID: PMC4035506.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    33. Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease. J Neurochem. 2014 Jan; 128(2):305-14. Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. PMID: 24032979; PMCID: PMC3971632.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    34. The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. PLoS Pathog. 2011 Mar; 7(3):e1001317. Ayers JI, Schutt CR, Shikiya RA, Aguzzi A, Kincaid AE, Bartz JC. PMID: 21437239; PMCID: PMC3060105.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCellsPHPublic Health
    35. Coinfecting prion strains compete for a limiting cellular resource. J Virol. 2010 Jun; 84(11):5706-14. Shikiya RA, Ayers JI, Schutt CR, Kincaid AE, Bartz JC. PMID: 20237082; PMCID: PMC2876617.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    36. Prion strain targeting independent of strain-specific neuronal tropism. J Virol. 2009 Jan; 83(1):81-7. Ayers JI, Kincaid AE, Bartz JC. PMID: 18971281; PMCID: PMC2612296.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    37. Prion interference is due to a reduction in strain-specific PrPSc levels. J Virol. 2007 Jan; 81(2):689-97. Bartz JC, Kramer ML, Sheehan MH, Hutter JA, Ayers JI, Bessen RA, Kincaid AE. PMID: 17079313; PMCID: PMC1797475.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
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