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Carlo Condello, PhD

Title(s)Assistant Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Phone415-502-7075
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Northwestern UniversityPh.D.2011Neuroscience
    Yale UniversityPostdoctoral2012Neurology
    UCSFPostdoctoral2015Insitute for Neurodegenerative Diseases

    Collapse Overview 
    Collapse Overview
    Neuroscientist with interests in the cell and molecular biology of neurodegenerative and autoimmune diseases, neuron-glial interactions, protein misfolding/prion mechanisms, in vivo/in vitro optical imaging techniques and developing animal models for preclinical studies.

    Collapse Research 
    Collapse Research Activities and Funding
    Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease
    NIH/NIA RF1AG061874Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. Aß and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Sci Transl Med. 2019 May 01; 11(490). PMID: 31043574.
      View in: PubMed
    2. Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 Jul; 101:56-69. PMID: 31010726.
      View in: PubMed
    3. Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nat Struct Mol Biol. 2018 May; 25(5):384-393. PMID: 29728653.
      View in: PubMed
    4. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB. Structural heterogeneity and intersubject variability of Aß in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E782-E791. PMID: 29311311.
      View in: PubMed
    5. Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E11029-E11036. PMID: 29203673.
      View in: PubMed
    6. Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB. A novel vector for transgenesis in the rat CNS. Acta Neuropathol Commun. 2017 Nov 21; 5(1):84. PMID: 29157304.
      View in: PubMed
    7. Condello C, Yuan P, Grutzendler J. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging. Biol Psychiatry. 2018 02 15; 83(4):377-387. PMID: 29169609.
      View in: PubMed
    8. Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem. 2017 09; 9(9):874-881. PMID: 28837163.
      View in: PubMed
    9. Condello C, Stöehr J. Aß propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease. Neurobiol Dis. 2018 Jan; 109(Pt B):191-200. PMID: 28359847.
      View in: PubMed
    10. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 10 05; 92(1):252-264. PMID: 27710785.
      View in: PubMed
    11. Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB. Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice. J Pharmacol Exp Ther. 2016 09; 358(3):537-47. PMID: 27317802; PMCID: PMC4998675 [Available on 09/01/17].
      View in: PubMed, PubMed Central
    12. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 05 18; 90(4):724-39. PMID: 27196974; PMCID: PMC4898967 [Available on 05/18/17].
      View in: PubMed, PubMed Central
    13. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. PMID: 26224882; PMCID: PMC4576665 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    14. Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aß42 hotspots around plaques. Nat Commun. 2015 Jan 29; 6:6176. PMID: 25630253; PMCID: PMC4311408.
      View in: PubMed, PubMed Central
    15. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aß prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. PMID: 24982137; PMCID: PMC4104853.
      View in: PubMed, PubMed Central
    16. Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aß prions from Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10323-8. PMID: 24982139.
      View in: PubMed
    17. Abraham J, Fox PD, Condello C, Bartolini A, Koh S. Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures. Neurobiol Dis. 2012 May; 46(2):425-30. PMID: 22366182; PMCID: PMC3323726.
      View in: PubMed, PubMed Central
    18. Condello C, Schain A, Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Sci Rep. 2011; 1:19. PMID: 22355538; PMCID: PMC3216507.
      View in: PubMed, PubMed Central
    19. Liu Z, Condello C, Schain A, Harb R, Grutzendler J. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-ß phagocytosis. J Neurosci. 2010 Dec 15; 30(50):17091-101. PMID: 21159979; PMCID: PMC3077120.
      View in: PubMed, PubMed Central
    20. Kalkonde YV, Morgan WW, Sigala J, Maffi SK, Condello C, Kuziel W, Ahuja SS, Ahuja SK. Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain Res. 2007 Jan 12; 1128(1):1-11. PMID: 17126305.
      View in: PubMed
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