Carlo Condello, PhD

Title(s)Associate Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #314A
San Francisco CA 94158
Phone415-502-7075
ORCID ORCID Icon0000-0002-8454-5360 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    Northwestern UniversityPh.D.2011Neuroscience
    Yale UniversityPostdoctoral2012Neurology
    UCSFPostdoctoral2015Insitute for Neurodegenerative Diseases
    Collapse awards and honors
    UCSF2021  - 2024John A. Watson Faculty Scholar
    UCSF2021  - 2023Ludwig Family Foundation; Early Career Award
    UCSF2022  - 2024Thome Memorial Foundation; Alzheimer's Disease Drug Discovery Award
    UCSF2022  - 2023Sandler Foundation; Program for Breakthrough Biomedical Research, New Frontier Award

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity. bioRxiv. 2025 Feb 25. Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA. PMID: 40060520; PMCID: PMC11888210.
      View in: PubMed   Mentions:
    2. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv. 2024 Nov 04. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. PMID: 37398204; PMCID: PMC10312804.
      View in: PubMed   Mentions: 1  
    3. Expanding the Prion Paradigm to Include Alzheimer and Parkinson Diseases. JAMA Neurol. 2024 Oct 01; 81(10):1023-1024. Condello C, Westaway D, Prusiner SB. PMID: 39158847.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs. bioRxiv. 2024 Sep 02. Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE. PMID: 39282355; PMCID: PMC11398390.
      View in: PubMed   Mentions:
    5. Severe neurodegeneration in brains of transgenic rats producing human tau prions. Acta Neuropathol. 2024 Aug 20; 148(1):25. Ayers J, Lopez TP, Steele IT, Oehler A, Roman-Albarran R, Cleveland E, Chong A, Carlson GA, Condello C, Prusiner SB. PMID: 39160375; PMCID: PMC11333523.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta Neuropathol Commun. 2024 06 12; 12(1):94. Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C. PMID: 38867338; PMCID: PMC11167798.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv. 2024 May 28. Ghosh U, Tse E, Yang H, Shi M, Carlo CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C. PMID: 38617229; PMCID: PMC11014571.
      View in: PubMed   Mentions:
    8. De novo design of peptides that bind specific conformers of α-synuclein. Chem Sci. 2024 Jun 05; 15(22):8414-8421. Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF. PMID: 38846390; PMCID: PMC11151861.
      View in: PubMed   Mentions: 1  
    9. Type-I-interferon-responsive microglia shape cortical development and behavior. Cell. 2024 Apr 11; 187(8):1936-1954.e24. Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV. PMID: 38490196; PMCID: PMC11015974.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    10. De novo Design of Peptides that Bind Specific Conformers of α-Synuclein. bioRxiv. 2023 Nov 16. Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF. PMID: 38014268; PMCID: PMC10680688.
      View in: PubMed   Mentions:
    11. Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease. J Proteome Res. 2023 11 03; 22(11):3475-3488. Kandi S, Cline EN, Rivera BM, Viola KL, Zhu J, Condello C, LeDuc RD, Klein WL, Kelleher NL, Patrie SM. PMID: 37847596; PMCID: PMC10840081.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Total Chemical Synthesis of Glycosylated TREM2 Ectodomain. ACS Chem Neurosci. 2023 06 07; 14(11):2243-2251. Wijegunawardena G, Castillo E, Henrickson B, Davis R, Condello C, Wu H. PMID: 37235776; PMCID: PMC10786670.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2220984120. Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB. PMID: 36952379; PMCID: PMC10068802.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Type I interferon responsive microglia shape cortical development and behavior. bioRxiv. 2023 Mar 20. Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Cuevas B, Vainchtein ID, Silva NJ, Xiao Y, Lidsky PV, Wang EY, Taloma SE, Nakao-Inoue H, Schwer B, Andino R, Nowakowski TJ, Molofsky AV. PMID: 35233577; PMCID: PMC8887080.
      View in: PubMed   Mentions:
    15. EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. Proc Natl Acad Sci U S A. 2023 03 21; 120(12):e2300769120. Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. PMID: 36927157; PMCID: PMC10041141.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    16. CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model. Nat Commun. 2023 01 09; 14(1):118. Johnson NR, Yuan P, Castillo E, Lopez TP, Yue W, Bond A, Rivera BM, Sullivan MC, Hirouchi M, Giles K, Aoyagi A, Condello C. PMID: 36624100; PMCID: PMC9829908.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    17. Aβ and Tau Prions Causing Alzheimer's Disease. Methods Mol Biol. 2023; 2561:293-337. Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB. PMID: 36399277.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    18. Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 2022 11 16; 119(46):e2212954119. Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. PMID: 36343257; PMCID: PMC9674250.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nat Commun. 2022 04 12; 13(1):1969. Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L. PMID: 35413950; PMCID: PMC9005658.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    20. Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB. PMID: 35115402; PMCID: PMC8833220.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    21. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF. PMID: 35082148; PMCID: PMC8812518.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    22. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathol Commun. 2021 12 27; 9(1):201. Maxwell AM, Yuan P, Rivera BM, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C. PMID: 34961556; PMCID: PMC8711167.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    23. Prion biology: implications for Alzheimer's disease therapeutics. Lancet Neurol. 2020 10; 19(10):802-803. Condello C, DeGrado WF, Prusiner SB. PMID: 32949533.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    24. Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Sci Transl Med. 2019 05 01; 11(490). Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. PMID: 31043574; PMCID: PMC6640844.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    25. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 07; 101:56-69. Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726; PMCID: PMC6561733.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nat Struct Mol Biol. 2018 05; 25(5):384-393. Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. PMID: 29728653; PMCID: PMC5942583.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    27. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E782-E791. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB. PMID: 29311311; PMCID: PMC5789926.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    28. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E11029-E11036. Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB. PMID: 29203673; PMCID: PMC5754811.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    29. A novel vector for transgenesis in the rat CNS. Acta Neuropathol Commun. 2017 Nov 21; 5(1):84. Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB. PMID: 29157304; PMCID: PMC5697436.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    30. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging. Biol Psychiatry. 2018 02 15; 83(4):377-387. Condello C, Yuan P, Grutzendler J. PMID: 29169609; PMCID: PMC5767550.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    31. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem. 2017 09; 9(9):874-881. Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. PMID: 28837163; PMCID: PMC5759337.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    32. Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease. Neurobiol Dis. 2018 Jan; 109(Pt B):191-200. Condello C, Stöehr J. PMID: 28359847.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    33. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 10 05; 92(1):252-264. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. PMID: 27710785.
      View in: PubMed   Mentions: 100     Fields:    
    34. Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice. J Pharmacol Exp Ther. 2016 09; 358(3):537-47. Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB. PMID: 27317802; PMCID: PMC4998675.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    35. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 05 18; 90(4):724-39. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. PMID: 27196974; PMCID: PMC4898967.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimalsCells
    36. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. PMID: 26224882; PMCID: PMC4576665.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    37. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun. 2015 Jan 29; 6:6176. Condello C, Yuan P, Schain A, Grutzendler J. PMID: 25630253; PMCID: PMC4311408.
      View in: PubMed   Mentions: 309     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. PMID: 24982137; PMCID: PMC4104853.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    39. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10323-8. Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. PMID: 24982139; PMCID: PMC4104857.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimals
    40. Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures. Neurobiol Dis. 2012 May; 46(2):425-30. Abraham J, Fox PD, Condello C, Bartolini A, Koh S. PMID: 22366182; PMCID: PMC3323726.
      View in: PubMed   Mentions: 68     Fields:    
    41. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Sci Rep. 2011; 1:19. Condello C, Schain A, Grutzendler J. PMID: 22355538; PMCID: PMC3216507.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    42. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. J Neurosci. 2010 Dec 15; 30(50):17091-101. Liu Z, Condello C, Schain A, Harb R, Grutzendler J. PMID: 21159979; PMCID: PMC3077120.
      View in: PubMed   Mentions: 158     Fields:    
    43. Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain Res. 2007 Jan 12; 1128(1):1-11. Kalkonde YV, Morgan WW, Sigala J, Maffi SK, Condello C, Kuziel W, Ahuja SS, Ahuja SK. PMID: 17126305.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
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