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Jeanette McCarthy, MPH, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address401 Parnassus Ave, LangPorter
San Francisco CA 94143
EmailJeanette.McCarthy@ucsf.edu
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    As a genome scientist, I spent years doing research on the genetic underpinnings of complex diseases, both infectious and chronic, and working to advance the field of precision medicine. More recently, I've turned my attention to educating stakeholders in this field. I believe informed consumers will play a major role in their health care going forward.In 2014, I helped launch the first consumer-facing magazine in this field, Genome (genomemag.com), where I was founding Editor-in-Chief. Health care providers also require education that is accessible and practical. I have developed courses in precision medicine at UC Berkeley Extension and through UCSF via Coursera (www.coursera.org/course/genomicmedicine). I also design and delivers workshops, symposia and webinars on more general as well as technical topics related to precision medicine through my consulting business, Precision Medicine Advisors (precisionmedicineadvisors.com) and the Precision Medicine Foundation.


    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenetics of lipid response to estrogen therapy
    NIH/NHLBI R01HL085191Jul 1, 2006 - Jun 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Delaney SK, Hultner ML, Jacob HJ, Ledbetter DH, McCarthy J, Ball M, Beckman KB, Belmont JW, Bloss CS, Christman MF, Cosgrove A, Damiani SA, Danis T, Delledonne M, Dougherty MJ, Dudley JT, Faucett WA, Friedman JR, Haase DH, Hays TS, Heilsberg S, Huber J, Kaminsky L, Ledbetter N, Lee WH, Levin E, Libiger O, Linderman M, Love RL, Magnus DC, Martland A, McClure SL, Megill SE, Messier H, Nussbaum RL, Palaniappan L, Patay BA, Popovich BW, Quackenbush J, Savant MJ, Su MM, Terry SF, Tucker S, Wong WT, Green RC. Toward clinical genomics in everyday medicine: perspectives and recommendations. Expert Rev Mol Diagn. 2016 May; 16(5):521-32. PMID: 26810587.
      View in: PubMed
    2. Chang MT, McCarthy J, Shin J. Clinical application of pharmacogenetics: focusing on practical issues. Pharmacogenomics. 2015 Oct; 16(15):1733-41. PMID: 26411302.
      View in: PubMed
    3. McCarthy J. Driving personalized medicine forward: the who, what, when, and how of educating the health-care workforce. Mol Genet Genomic Med. 2014 Nov; 2(6):455-7. PMID: 25614866; PMCID: PMC4303214.
    4. McCarthy J, McLeod HL, Ginsburg GS. Genomic medicine: a decade of successes, challenges, and opportunities. Sci Transl Med. 2013 Jun 12; 5(189):189sr4. PMID: 23761042.
      View in: PubMed
    5. Belsky DW, Moffitt TE, Sugden K, Williams B, Houts R, McCarthy J, Caspi A. Development and evaluation of a genetic risk score for obesity. Biodemography Soc Biol. 2013; 59(1):85-100. PMID: 23701538; PMCID: PMC3671353.
    6. Chiba-Falek O, Linnertz C, Guyton J, Gardner SD, Roses AD, McCarthy J, Patel K. Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection. Hum Genet. 2012 Dec; 131(12):1911-20. PMID: 22898894.
      View in: PubMed
    7. Lucas JE, Thompson JW, Dubois LG, McCarthy J, Tillmann H, Thompson A, Shire N, Hendrickson R, Dieguez F, Goldman P, Schwarz K, Patel K, McHutchison J, Moseley MA. Metaprotein expression modeling for label-free quantitative proteomics. BMC Bioinformatics. 2012; 13:74. PMID: 22559859; PMCID: PMC3436780.
    8. Linnertz C, Saunders AM, Lutz MW, Crenshaw DM, Grossman I, Burns DK, Whitfield KE, Hauser MA, McCarthy J, Ulmer M, Allingham R, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. Characterization of the poly-T variant in the TOMM40 gene in diverse populations. PLoS One. 2012; 7(2):e30994. PMID: 22359560; PMCID: PMC3281049.
    9. Corsetti JP, Ryan D, Moss AJ, McCarthy J, Goldenberg I, Zareba W, Sparks CE. Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels. Thromb Haemost. 2011 Dec; 106(6):1170-8. PMID: 22011848.
      View in: PubMed
    10. Cyr DD, Lucas JE, Thompson JW, Patel K, Clark PJ, Thompson A, Tillmann HL, McHutchison JG, Moseley MA, McCarthy J. Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C. PLoS One. 2011; 6(7):e21854. PMID: 21750736; PMCID: PMC3130042.
    11. Patel K, Lucas JE, Thompson JW, Dubois LG, Tillmann HL, Thompson AJ, Uzarski D, Califf RM, Moseley MA, Ginsburg GS, McHutchison JG, McCarthy J. High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients. Hepatology. 2011 Jun; 53(6):1809-18. PMID: 21381069.
      View in: PubMed
    12. Tillmann HL, Patel K, Muir AJ, Guy CD, Li JH, Lao XQ, Thompson A, Clark PJ, Gardner SD, McHutchison JG, McCarthy J. Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. J Hepatol. 2011 Dec; 55(6):1195-200. PMID: 21703198; PMCID: PMC3763913.
    13. Benjamin AM, Suchindran S, Pearce K, Rowell J, Lien LF, Guyton JR, McCarthy J. Gene by sex interaction for measures of obesity in the framingham heart study. J Obes. 2011; 2011:329038. PMID: 21253498; PMCID: PMC3021872.
    14. McCarthy J, Saith S, Linnertz C, Burke JR, Hulette CM, Welsh-Bohmer KA, Chiba-Falek O. The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression. Neurobiol Aging. 2012 Jul; 33(7):1485.e1-8. PMID: 21185108; PMCID: PMC3117021.
    15. McCarthy J, Linnertz C, Saucier L, Burke JR, Hulette CM, Welsh-Bohmer KA, Chiba-Falek O. The effect of SNCA 3' region on the levels of SNCA-112 splicing variant. Neurogenetics. 2011 Feb; 12(1):59-64. PMID: 21046180; PMCID: PMC3030669.
    16. Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, Lokhnygina Y, Kullig U, Göbel U, Capka E, Wiegand J, Schiefke I, Güthoff W, Grüngreiff K, König I, Spengler U, McCarthy J, Shianna KV, Goldstein DB, McHutchison JG, Timm J, Nattermann J. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology. 2010 Nov; 139(5):1586-92, 1592.e1. PMID: 20637200.
      View in: PubMed
    17. Thompson AJ, Muir AJ, Sulkowski MS, Patel K, Tillmann HL, Clark PJ, Naggie S, Fellay J, Ge D, McCarthy J, Goldstein DB, McHutchison JG. Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype. Hepatology. 2010 Dec; 52(6):2243-4. PMID: 20890887.
      View in: PubMed
    18. Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG, McCarthy J. Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. Hepatology. 2010 Jun; 51(6):1904-11. PMID: 20235331; PMCID: PMC2921623.
    19. Suchindran S, Rivedal D, Guyton JR, Milledge T, Gao X, Benjamin A, Rowell J, Ginsburg GS, McCarthy J. Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. PLoS Genet. 2010 Apr; 6(4):e1000928. PMID: 20442857; PMCID: PMC2861686.
    20. McCarthy J, Li JH, Thompson A, Suchindran S, Lao XQ, Patel K, Tillmann HL, Muir AJ, McHutchison JG. Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. Gastroenterology. 2010 Jun; 138(7):2307-14. PMID: 20176026; PMCID: PMC2883666.
    21. Chiba-Falek O, Nichols M, Suchindran S, Guyton J, Ginsburg GS, Barrett-Connor E, McCarthy J. Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. BMC Med Genet. 2010; 11:9. PMID: 20085651; PMCID: PMC2822818.
    22. Suchindran S, Vana AM, Shaffer RA, Alcaraz JE, McCarthy J. Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004. Genet Med. 2009 Jul; 11(7):542-7. PMID: 19606541.
      View in: PubMed
    23. McCarthy J, Somji A, Weiss LA, Steffy B, Vega R, Barrett-Connor E, Talavera G, Glynne R. Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction. J Clin Endocrinol Metab. 2009 May; 94(5):1789-96. PMID: 19276229; PMCID: PMC2684479.
    24. Ginsburg GS, Ginsburg GS, J McCarthy J. Transforming the practice of medicine using genomics. Clin Cases Miner Bone Metab. 2009 Jan; 6(1):25-8. PMID: 22461094; PMCID: PMC2781216.
    25. McCarthy J, Topol EJ. Validity of reported genetic risk factors for acute coronary syndrome. JAMA. 2007 Oct 17; 298(15):1758; author reply 1759. PMID: 17940228.
      View in: PubMed
    26. Nelson T, Perez A, Alcaraz J, Talavera G, McCarthy J. Family History of Diabetes, Acculturation, and the Metabolic Syndrome among Mexican Americans: Proyecto SALSA. Metab Syndr Relat Disord. 2007 Sep; 5(3):262-9. PMID: 18370780.
      View in: PubMed
    27. Ginsburg GS, Shah SH, McCarthy J. Taking cardiovascular genetic association studies to the next level. J Am Coll Cardiol. 2007 Sep 4; 50(10):930-2. PMID: 17765118.
      View in: PubMed
    28. McCarthy J. Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome. Nutr Metab Cardiovasc Dis. 2007 Feb; 17(2):153-61. PMID: 17306735.
      View in: PubMed
    29. McCarthy J. Life, diversity and the pursuit of haplotypes. Nat Biotechnol. 2005 Nov; 23(11):1376-7. PMID: 16273067.
      View in: PubMed
    30. Moss AJ, Ryan D, Oakes D, Goldstein RE, Greenberg H, Bodenheimer MM, Brown MW, Case RB, Dwyer EM, Eberly SW, Francis CW, Gillespie JA, Krone RJ, Lichstein E, MacCluer JW, Marcus FI, McCarthy J, Sparks CE, Zareba W. Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction. Am J Cardiol. 2005 Jul 15; 96(2):177-82. PMID: 16018837.
      View in: PubMed
    31. Jefferson BK, Foster JH, McCarthy J, Ginsburg G, Parker A, Kottke-Marchant K, Topol EJ. Aspirin resistance and a single gene. Am J Cardiol. 2005 Mar 15; 95(6):805-8. PMID: 15757620.
      View in: PubMed
    32. Richard E, von Muhlen D, Barrett-Connor E, Alcaraz J, Davis R, McCarthy J. Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study. Atherosclerosis. 2005 Jun; 180(2):255-62. PMID: 15910850.
      View in: PubMed
    33. Stenina OI, Byzova TV, Adams JC, McCarthy J, Topol EJ, Plow EF. Coronary artery disease and the thrombospondin single nucleotide polymorphisms. Int J Biochem Cell Biol. 2004 Jun; 36(6):1013-30. PMID: 15094117.
      View in: PubMed
    34. McCarthy J, Parker A, Salem R, Moliterno DJ, Wang Q, Plow EF, Rao S, Shen G, Rogers WJ, Newby LK, Cannata R, Glatt K, Topol EJ. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. J Med Genet. 2004 May; 41(5):334-41. PMID: 15121769; PMCID: PMC1579684.
    35. Wessel J, Topol EJ, Ji M, Meyer J, McCarthy J. Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction. Am Heart J. 2004 May; 147(5):905-9. PMID: 15131549.
      View in: PubMed
    36. Gayà A, Esteve A, Casabona J, McCarthy J, Martorell J, Schulz TF, Whitby D. Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients. AIDS. 2004 Jan 23; 18(2):199-204. PMID: 15075536.
      View in: PubMed
    37. McCarthy J. Advances in pharmacogenomic research and development. Mol Biotechnol. 2003 Nov; 25(3):275-82. PMID: 14668540.
      View in: PubMed
    38. McCarthy J, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. Hum Genet. 2003 Dec; 114(1):87-98. PMID: 14557872.
      View in: PubMed
    39. McCarthy J, Lehner T, Reeves C, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ. Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease. J Med Genet. 2003 Jun; 40(6):453-8. PMID: 12807968; PMCID: PMC1735488.
    40. McCarthy J, Lewitzky S, Reeves C, Permutt A, Glaser B, Groop LC, Lehner T, Meyer JM. Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. Hum Hered. 2003; 55(4):163-70. PMID: 14566094.
      View in: PubMed
    41. Ginsburg GS, McCarthy J. Personalized medicine: revolutionizing drug discovery and patient care. Trends Biotechnol. 2001 Dec; 19(12):491-6. PMID: 11711191.
      View in: PubMed
    42. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O'Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina O, Daley GQ. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation. 2001 Nov 27; 104(22):2641-4. PMID: 11723011.
      View in: PubMed
    43. McCarthy J, Hilfiker R. The use of single-nucleotide polymorphism maps in pharmacogenomics. Nat Biotechnol. 2000 May; 18(5):505-8. PMID: 10802616.
      View in: PubMed
    44. Chen JJ, Hollenbach JA, Trachtenberg EA, Just JJ, Carrington M, Rønningen KS, Begovich A, King MC, McWeeney S, Mack SJ, Erlich HA, Thomson G. Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups. Tissue Antigens. 1999 Dec; 54(6):533-42. PMID: 10674966.
      View in: PubMed
    45. Rousseau CM, Just JJ, Abrams EJ, Casabona J, Stein Z, King MC. CCR5del32 in perinatal HIV-1 infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 1; 16(4):239-42. PMID: 9402069.
      View in: PubMed
    46. Lloyd CM, Gonzalo JA, Salant DJ, Just J, Gutierrez-Ramos JC. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest. 1997 Sep 1; 100(5):963-71. PMID: 9276713; PMCID: PMC508271.
    47. Just JJ, King MC, Thomson G, Klitz W. African-American HLA class II allele and haplotype diversity. Tissue Antigens. 1997 May; 49(5):547-55. PMID: 9174158.
      View in: PubMed
    48. Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, Ostrander EA. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res. 1997 Mar 15; 57(6):1194-8. PMID: 9067292.
      View in: PubMed
    49. Just JJ, King MC, Thomson G, Klitz W. African-American HLA class II allele and haplotype diversity. Tissue Antigens. 1996 Dec; 48(6):636-44. PMID: 9008305.
      View in: PubMed
    50. Just JJ, Casabona J, Bertrán J, Montané C, Fortuny C, Rodrigo C, Mur A, Bosque M, Jovane L, King MC. MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain. Tissue Antigens. 1996 Apr; 47(4):313-8. PMID: 8773321.
      View in: PubMed
    51. Keet IP, Klein MR, Just JJ, Kaslow RA. The role of host genetics in the natural history of HIV-1 infection: the needles in the haystack. AIDS. 1996; 10 Suppl A:S59-67. PMID: 8883611.
      View in: PubMed
    52. Just JJ. Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected]. Hum Immunol. 1995 Nov; 44(3):156-69. PMID: 8666552.
      View in: PubMed
    53. Just JJ, Abrams E, Louie LG, Urbano R, Wara D, Nicholas SW, Stein Z, King MC. Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1. J Pediatr. 1995 Oct; 127(4):544-9. PMID: 7562274.
      View in: PubMed
    54. Ginther C, Corach D, Penacino GA, Rey JA, Carnese FR, Hutz MH, Anderson A, Just J, Salzano FM, King MC. Genetic variation among the Mapuche Indians from the Patagonian region of Argentina: mitochondrial DNA sequence variation and allele frequencies of several nuclear genes. EXS. 1993; 67:211-9. PMID: 8400690.
      View in: PubMed
    55. Just J, Louie L, Abrams E, Nicholas SW, Wara D, Stein Z, King MC. Genetic risk factors for perinatally acquired HIV-1 infection. Paediatr Perinat Epidemiol. 1992 Apr; 6(2):215-24. PMID: 1584723.
      View in: PubMed
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