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Jessica Hua, PhD, MA

Photo of Jessica Hua, PhD, MA
Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address1550 Fourth Street, #A332
San Francisco CA 94158
Phone415-476-7057
ORCID ORCID Icon0000-0003-4456-2585 Additional info
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    Collapse Biography 
    Collapse education and training
    San Francisco VA Health Care System / University of California San Francisco02/2023Postdoctoral Fellowship
    University of MissouriPhD06/2020Clinical Psychology
    San Francisco VA Health Care System06/2020Clinical Internship
    University of MissouriMA08/2014Clinical Psychology
    University of California San DiegoBS06/2012Psychology
    Collapse awards and honors
    2025Journal of Psychopathology and Clinical Science Editorial Fellow
    2025Society of Biological Psychiatry (SOBP) Early Career Investigator Travel Award
    2024Career Development Institute for Psychiatry Fellow (2-year early career training program)
    2023UCSF Clinical Teaching Certificate
    2023UCSF General Teaching Certificate
    2023UCSF Psychiatry Trainee Research Award
    2021NeuroHackademy Program Awardee
    2021Research Society on Alcoholism (RSA) Junior Investigator Award
    2021Schizophrenia International Research Society (SIRS) Early Career Award
    2020University of Missouri Department of Psychological Sciences Graduate Excellence in Mentoring
    2019Academy of Psychological Clinical Science (APCS) Clinical Science Student Training Award ($1,000)
    2019University of Missouri Graduate Student Excellence Award Nominee
    2019University of Missouri Dissertation Research Award ($400)
    2018University of Missouri Department of Psychological Sciences Graduate Student Excellence Award
    2018University of Missouri Graduate Student Travel Award ($400)
    2017University of Missouri Graduate Student Travel Award ($400)
    2016University of Missouri Graduate Student Travel Award ($450)
    2016University of Missouri Summer Grant Writing Fellowship ($3,575)
    2015University of Missouri Graduate Fellowship ($1,000)
    2012Phi Beta Kappa
    2012University of California, San Diego Latin Honors: Cum Laude
    2012University of California, San Diego Psychology Departmental Honors: High Distinction
    2008  - 2012University of California, San Diego Provost Honors

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Social and Behavioral Determinants of Health and Associations with Premature Brain Maturation and Psychosis Conversion in Individuals at Clinical-High Risk for Psychosis
    University of California San Francisco Nancy Adler Seed GrantNov 1, 2024 - Feb 28, 2026
    Role: Principal Investigator
    Description: Social and behavioral determinants of health (SBDHs) predict psychosis conversion. Yet, how do SBDHs “get under the skin” and influence psychosis. SBDHs can trigger biological changes leading to premature maturation. Premature brain maturation (or brain aging) is observed in schizophrenia. Moreover, premature brain maturation predicts psychosis conversion in individuals at clinical high-risk for psychosis (CHR-P). The proposed study aims to assess prevalence rates of SBDHs and examine brain maturation as a candidate biological intermediary through which SBDHs increase conversion risk.
    Neuromodulation of Plasticity and Cognitive Functioning in Schizophrenia
    Department of Veteran Affairs, VHA CDA-2Oct 1, 2024 - Sep 30, 2029
    Role: Principal Investigator
    Description: Cognitive dysfunction is the strongest predictor of poor functional outcomes in schizophrenia, yet available cognitive enhancement treatments yield modest effects. Converging evidence suggests that basic mechanisms of neuroplasticity, the fundamental building blocks of learning and memory, are impaired and contribute to cognitive deficits in schizophrenia, which in turn limit treatment benefits for cognitively impaired Veterans. The proposed study aims to examine neuromodulatory methods for enhancing neuroplasticity and to advance the field’s knowledge of neuroplasticity mechanisms, with particular focus on how modulation of these mechanisms relates to enhanced cognition.
    Dual-tuned 1H/2H Head Coil for 7T MRI
    University of California San Francisco Shared Technology RAPJan 1, 2024 - Dec 31, 2024
    Role: Co-Investigator
    Description: A readily accessible, non-invasive imaging modality, like DMI, could improve our understanding of metabolic flux, such as assessing mitochondrial energy metabolism and glutamate transmission. The primary goal of the proposal is to utilize the 1H/2H head coil to combine 2H and 1H MR Spectroscopy (MRS) to facilitate a direct measure mitochondrial function in neurological and psychiatric diseases after oral glucose administration (dose less than 2 cans of Coca-Cola).
    Neuro-oscillatory Mechanisms Underlying Deficient Neuroplasticity in Schizophrenia
    Department of Veteran Affairs, VHA, VISN 21 ECAPOct 1, 2022 - Sep 30, 2024
    Role: Principal Investigator
    Description: Long-term potentiation is a basic neural mechanism responsible for learning and memory. Recent data suggest that it is impaired in schizophrenia, but it is unclear what the underlying mechanisms are and what conditions are necessary to successfully induce long-term potentiation in schizophrenia. The primary goal of the proposed research is to examine the oscillatory mechanisms underlying long-term potentiation in schizophrenia and their associations with cognitive dysfunction in two archival datasets.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity. Biol Psychiatry Glob Open Sci. 2026 Mar; 6(2):100664. Hua JPY, Roach BJ, Hamilton HK, Bachman PM, Belger A, Carrión RE, Duncan E, Johannesen JK, Light GA, Niznikiewicz M, Addington J, Bearden CE, Cadenhead KS, Perkins DO, Stone WS, Walker EF, Woods SW, Cannon TD, Mathalon DH. PMID: 41646831; PMCID: PMC12870832.
      View in: PubMed   Mentions:
    2. Microbial responses to antibiotics cryptically shift the direction of disease outcomes. Sci Rep. 2025 Jul 02; 15(1):22596. Velasquez I, Ricci K, Milusich E, Tuthill BF, Sauer K, Hernández-Gómez O, Hua J. PMID: 40592929; PMCID: PMC12219847.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Pons connectivity correlates with neurophysiological and clinical signatures of predictive coding in psychosis. Neuropsychopharmacology. 2024 Nov; 50(1):351-352. Abram SV, Hua JPY. PMID: 39039138; PMCID: PMC11526116.
      View in: PubMed   Mentions:    Fields:    
    4. Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis. Schizophr Bull. 2024 08 27; 50(5):1159-1170. Hua JPY, Abram SV, Loewy RL, Stuart B, Fryer SL, Vinogradov S, Mathalon DH. PMID: 38815987; PMCID: PMC11349027.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Brain Morphometry Normative Modeling-Omit Global Thickness. JAMA Psychiatry. 2024 Aug 01; 81(8):844. Hua JPY, Mathalon DH. PMID: 38959021.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Adjustment of Regional Cortical Thickness Measures for Global Cortical Thickness Obscures Deficits Across the Schizophrenia Spectrum: A Cautionary Note About Normative Modeling of Brain Imaging Data. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Jun; 10(6):666-672. Hua JPY, Fryer SL, Stuart B, Loewy RL, Vinogradov S, Mathalon DH. PMID: 38908749.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jul; 9(7):693-702. Abram SV, Hua JPY, Nicholas S, Roach B, Keedy S, Sweeney JA, Mathalon DH, Ford JM. PMID: 38311290; PMCID: PMC11227403.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Impact of Alcohol Use, Traumatic Stress, and Cigarette Smoking on Cognitive Functioning in Veterans With Co-occurring Alcohol Use Disorder and Posttraumatic Stress Disorder. Mil Med. 2023 07 22; 188(7-8):e2208-e2216. Hua JPY, Cano M, Batki SL, Pennington DL. PMID: 36179109; PMCID: PMC10362996.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Population-level variation in insecticide tolerance across three life stages of the trematode Echinostoma trivolvis. Aquat Toxicol. 2023 Aug; 261:106626. Billet LS, Wuerthner VP, Relyea RA, Hoverman JT, Hua J. PMID: 37437313.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. Cortical and subcortical brain morphometry abnormalities in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia. Psychiatry Res Neuroimaging. 2023 07; 332:111653. Hua JPY, Loewy RL, Stuart B, Fryer SL, Niendam TA, Carter CS, Vinogradov S, Mathalon DH. PMID: 37121090; PMCID: PMC10362971.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia. Schizophr Res. 2023 05; 255:110-121. Hua JPY, Cummings J, Roach BJ, Fryer SL, Loewy RL, Stuart BK, Ford JM, Vinogradov S, Mathalon DH. PMID: 36989668; PMCID: PMC10705845.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Mismatch Negativity and Theta Oscillations Evoked by Auditory Deviance in Early Schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 12; 8(12):1186-1196. Hua JPY, Roach BJ, Ford JM, Mathalon DH. PMID: 36931469.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods. Front Psychiatry. 2022; 13:1069488. Hua JPY, Abram SV, Ford JM. PMID: 36620688; PMCID: PMC9815121.
      View in: PubMed   Mentions: 13  
    14. Advanced brain age correlates with greater rumination and less mindfulness in schizophrenia. Neuroimage Clin. 2023; 37:103301. Abram SV, Roach BJ, Hua JPY, Han LKM, Mathalon DH, Ford JM, Fryer SL. PMID: 36586360; PMCID: PMC9830317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Examining associations between social anhedonia and convergent thinking using the Remote Associates Test. Cogn Neuropsychiatry. 2022 11; 27(6):458-470. Spann DJ, Straub KT, Hua JPY, Pellegrini AM, Kerns JG. PMID: 36166749.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Consider the pons: bridging the gap on sensory prediction abnormalities in schizophrenia. Trends Neurosci. 2022 11; 45(11):798-808. Abram SV, Hua JPY, Ford JM. PMID: 36123224; PMCID: PMC9588719.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis. Schizophr Bull Open. 2022 Jan; 3(1):sgac028. Hua JPY, Mathalon DH. PMID: 39144757; PMCID: PMC11206002.
      View in: PubMed   Mentions: 4  
    18. Understanding Organismal Capacity to Respond to Anthropogenic Change: Barriers and Solutions. Integr Comp Biol. 2022 02 05; 61(6):2132-2144. Gabor CR, Kivlin SN, Hua J, Bickford N, Reiskind MOB, Wright TF. PMID: 34279616.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization. Drug Alcohol Depend. 2022 01 01; 230:109198. Hua JPY, de Lange SC, van den Heuvel MP, Boness CL, Trela CJ, McDowell YE, Merrill AM, Piasecki TM, Sher KJ, Kerns JG. PMID: 34861495; PMCID: PMC8837437.
      View in: PubMed   Mentions: 4     Fields:    
    20. Relations between lab indices of emotion dysregulation and negative affect reactivity in daily life in two independent studies. J Affect Disord. 2022 01 15; 297:217-224. Trull TJ, Hepp J, Wycoff AM, Vebares TJ, Fleming MN, Hua JPY, Yeung EW, Kerns JG. PMID: 34695499; PMCID: PMC8629845.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Associations between long-term psychosis risk, probabilistic category learning, and attenuated psychotic symptoms with cortical surface morphometry. Brain Imaging Behav. 2022 Feb; 16(1):91-106. Hua JPY, Karcher NR, Straub KT, Kerns JG. PMID: 34218406.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Daily-life negative affect in emotional distress disorders associated with altered frontoinsular emotion regulation and cortical gyrification. Cognitive Therapy and Research. 2021; (45):1-18. Hua JPY, Trull TJ, Merrill AM, Myers OTT, Straub KT, Kerns JG.
    23. Functional connectivity between the ventral anterior cingulate and amygdala during implicit emotional conflict regulation and daily-life emotion dysregulation. Neuropsychologia. 2021 07 30; 158:107905. Hua JPY, Trull TJ, Merrill AM, Tidwell EA, Kerns JG. PMID: 34058174.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Prospective Study Examining the Effects of Extreme Drinking on Brain Structure in Emerging Adults. Alcohol Clin Exp Res. 2020 11; 44(11):2200-2211. Hua JPY, Sher KJ, Boness CL, Trela CJ, McDowell YE, Merrill AM, Piasecki TM, Kerns JG. PMID: 32970324; PMCID: PMC7680366.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Psychosis risk is associated with decreased white matter integrity in limbic network corticostriatal tracts. Psychiatry Res Neuroimaging. 2020 07 30; 301:111089. Straub KT, Hua JPY, Karcher NR, Kerns JG. PMID: 32442837; PMCID: PMC7293570.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Alcohol use in young adults associated with cortical gyrification. Drug Alcohol Depend. 2020 04 01; 209:107925. Hua JPY, Piasecki TM, McDowell YE, Boness CL, Trela CJ, Merrill AM, Sher KJ, Kerns JG. PMID: 32088591; PMCID: PMC7127958.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Metacognitive Training for Individuals in the Early Stages of Psychosis. Int J Group Psychother. 2020 Jul; 70(3):456-465. Hua JPY, Kanas N. PMID: 38449223.
      View in: PubMed   Mentions: 1     Fields:    
    28. Daily-life affective instability in emotional distress disorders is associated with function and structure of posterior parietal cortex. Psychiatry Res Neuroimaging. 2020 02 29; 296:111028. Hua JPY, Trull TJ, Merrill AM, McCarty RM, Straub KT, Kerns JG. PMID: 31911320.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Examining associations between two different jumping to conclusions scores with positive schizotypy and recent distress. Cogn Neuropsychiatry. 2020 01; 25(1):45-56. Hua JPY, Karcher NR, Kerns JG. PMID: 31668129.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network. Cogn Affect Behav Neurosci. 2019 08; 19(4):998-1011. Hua JPY, Karcher NR, Merrill AM, O'Brien KJ, Straub KT, Trull TJ, Kerns JG. PMID: 30756347; PMCID: PMC6690819.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    31. Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk. Neuropsychopharmacology. 2019 10; 44(11):1967-1974. Karcher NR, Hua JPY, Kerns JG. PMID: 31272104; PMCID: PMC6784983.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Explicit and Implicit Affect and Judgment in Schizotypy. Front Psychol. 2019; 10:1491. Martin EA, Hua JPY, Straub KT, Kerns JG. PMID: 31312158; PMCID: PMC6613436.
      View in: PubMed   Mentions:
    33. Local adaptation of the MHC class IIβ gene in populations of wood frogs (Lithobates sylvaticus) correlates with proximity to agriculture. Infect Genet Evol. 2019 09; 73:197-204. Hernández-Gómez O, Kimble SJA, Hua J, Wuerthner VP, Jones DK, Mattes BM, Cothran RD, Relyea RA, Meindl GA, Hoverman JT. PMID: 31051273.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    34. Probabilistic Category Learning and Striatal Functional Activation in Psychosis Risk. Schizophr Bull. 2019 03 07; 45(2):396-404. Karcher NR, Hua JPY, Kerns JG. PMID: 29590478; PMCID: PMC6403050.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Childhood trauma and clinical high risk for psychosis. Schizophr Res. 2019 03; 205:10-14. Loewy RL, Corey S, Amirfathi F, Dabit S, Fulford D, Pearson R, Hua JPY, Schlosser D, Stuart BK, Mathalon DH, Vinogradov S. PMID: 29779964; PMCID: PMC6939986.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    36. Differentiating positive schizotypy and mania risk scales and their associations with spontaneous eye blink rate. Psychiatry Res. 2018 06; 264:58-66. Hua JPY, Kerns JG. PMID: 29627698.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Linking Ecology and Epidemiology to Understand Predictors of Multi-Host Responses to an Emerging Pathogen, the Amphibian Chytrid Fungus. PLoS One. 2017; 12(1):e0167882. Gervasi SS, Stephens PR, Hua J, Searle CL, Xie GY, Urbina J, Olson DH, Bancroft BA, Weis V, Hammond JI, Relyea RA, Blaustein AR. PMID: 28095428; PMCID: PMC5240985.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    38. Differences in sensitivity to the fungal pathogen Batrachochytrium dendrobatidis among amphibian populations. Conserv Biol. 2015 Oct; 29(5):1347-56. Bradley PW, Gervasi SS, Hua J, Cothran RD, Relyea RA, Olson DH, Blaustein AR. PMID: 26219571.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    39. Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia. Schizophr Res. 2014 Oct; 159(1):114-7. Twamley EW, Hua JP, Burton CZ, Vella L, Chinh K, Bilder RM, Kelsoe JR. PMID: 25139113.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    40. Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor. J Affect Disord. 2013 Sep 25; 150(3):948-54. Henry BL, Minassian A, Patt VM, Hua J, Young JW, Geyer MA, Perry W. PMID: 23759280; PMCID: PMC3759601.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
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