John Murnane, PhD

InstitutionUniversity of California San Francisco
DepartmentRadiation Oncology
Address2340 Sutter Street
San Francisco CA 94115
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    Chromosome instability resulting from double-strand breaks near telomeres
    NIH/NCI R01CA120205Jul 6, 2006 - May 31, 2016
    Role: Principal Investigator
    Mechanisms of formation of terminal deletions
    NIH/NIEHS R01ES008427Jan 1, 1997 - May 31, 2009
    Role: Principal Investigator
    NIH/NCI R01CA069044May 15, 1996 - Dec 31, 2005
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Muraki K, Murnane J. The DNA damage response at dysfunctional telomeres, and at interstitial and subtelomeric DNA double-strand breaks. Genes Genet Syst. 2018 Jan 20; 92(3):135-152. PMID: 29162774.
      View in: PubMed
    2. Alcaraz Silva B, Jones TJ, Murnane J. Differences in the recruitment of DNA repair proteins at subtelomeric and interstitial I-SceI endonuclease-induced DNA double-strand breaks. DNA Repair (Amst). 2017 01; 49:1-8. PMID: 27842255.
      View in: PubMed
    3. Janson C, Nyhan K, Murnane J. Replication Stress and Telomere Dysfunction Are Present in Cultured Human Embryonic Stem Cells. Cytogenet Genome Res. 2015; 146(4):251-60. PMID: 26517359.
      View in: PubMed
    4. Muraki K, Han L, Miller D, Murnane J. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015 Sep 18; 43(16):7911-30. PMID: 26209132; PMCID: PMC4652756.
    5. Murnane J. In memoriam: Robert Blair Painter. Radiat Res. 2015 Mar; 183(3):e49-50. PMID: 25763932.
      View in: PubMed
    6. Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane J, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015 Jan 21; 6:5990. PMID: 25606712; PMCID: PMC4516720.
    7. Li Z, Wang H, Wang Y, Murnane J, Dynan WS. Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiat Res. 2014 Nov; 182(5):573-9. PMID: 25329962.
      View in: PubMed
    8. Bakhoum SF, Kabeche L, Murnane J, Zaki BI, Compton DA. DNA-damage response during mitosis induces whole-chromosome missegregation. Cancer Discov. 2014 Nov; 4(11):1281-9. PMID: 25107667; PMCID: PMC4221427.
    9. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane J, Dynan WS. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013 Jul; 180(1):17-24. PMID: 23692479.
      View in: PubMed
    10. Muraki K, Han L, Miller D, Murnane J. The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genet. 2013 Mar; 9(3):e1003386. PMID: 23555296; PMCID: PMC3610639.
    11. Muraki K, Nyhan K, Han L, Murnane J. Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol. 2012; 2:135. PMID: 23061048; PMCID: PMC3463808.
    12. Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane J. PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. DNA Repair (Amst). 2011 Nov 10; 10(11):1164-73. PMID: 21945094; PMCID: PMC3208378.
    13. Murnane J. Telomere dysfunction and chromosome instability. Mutat Res. 2012 Feb 01; 730(1-2):28-36. PMID: 21575645; PMCID: PMC3178001.
    14. Miller D, Reynolds GE, Mejia R, Stark JM, Murnane J. Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst). 2011 May 05; 10(5):536-44. PMID: 21466975; PMCID: PMC3084351.
    15. Murnane J. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res. 2010 Jun 01; 70(11):4255-9. PMID: 20484032; PMCID: PMC2967490.
    16. Kulkarni A, Zschenker O, Reynolds G, Miller D, Murnane J. Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line. Mol Cell Biol. 2010 Feb; 30(3):578-89. PMID: 19933847; PMCID: PMC2812225.
    17. Zschenker O, Kulkarni A, Miller D, Reynolds GE, Granger-Locatelli M, Pottier G, Sabatier L, Murnane J. Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line. DNA Repair (Amst). 2009 Aug 06; 8(8):886-900. PMID: 19540174; PMCID: PMC2901176.
    18. Gao Q, Reynolds GE, Wilcox A, Miller D, Cheung P, Artandi SE, Murnane J. Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells. DNA Repair (Amst). 2008 Aug 02; 7(8):1233-49. PMID: 18502190; PMCID: PMC2597172.
    19. Ho CY, Murnane J, Yeung AK, Ng HK, Lo AW. Telomeres acquire distinct heterochromatin characteristics during siRNA-induced RNA interference in mouse cells. Curr Biol. 2008 Feb 12; 18(3):183-7. PMID: 18261910.
      View in: PubMed
    20. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane J. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells. 2007 Dec; 25(12):3085-92. PMID: 17823235.
      View in: PubMed
    21. Hosoi Y, Kapp LN, Murnane J, Matsumoto Y, Enomoto A, Ono T, Miyagawa K. Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. Biochem Biophys Res Commun. 2006 Sep 22; 348(2):728-34. PMID: 16890201.
      View in: PubMed
    22. Murnane J. Telomeres and chromosome instability. DNA Repair (Amst). 2006 Sep 08; 5(9-10):1082-92. PMID: 16784900.
      View in: PubMed
    23. Bailey SM, Murnane J. Telomeres, chromosome instability and cancer. Nucleic Acids Res. 2006; 34(8):2408-17. PMID: 16682448; PMCID: PMC1458522.
    24. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane J. Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol. 2006 Mar; 26(5):1865-78. PMID: 16479005; PMCID: PMC1430234.
    25. Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J, Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A, Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P, Collins C. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006 Mar; 16(3):394-404. PMID: 16461635; PMCID: PMC1415204.
    26. Sabatier L, Ricoul M, Pottier G, Murnane J. The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line. Mol Cancer Res. 2005 Mar; 3(3):139-50. PMID: 15798094.
      View in: PubMed
    27. Murnane J, Sabatier L. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays. 2004 Nov; 26(11):1164-74. PMID: 15499579.
      View in: PubMed
    28. Weier HU, Chu LW, Murnane J, Weier JF. Applications and technical challenges of fluorescence in situ hybridization in stem cell research. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):68-76. PMID: 14757416.
      View in: PubMed
    29. Bai Y, Murnane J. Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Mol Cancer Res. 2003 Dec; 1(14):1058-69. PMID: 14707289.
      View in: PubMed
    30. Bai Y, Murnane J. Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein. Hum Genet. 2003 Sep; 113(4):337-47. PMID: 12827497.
      View in: PubMed
    31. Morales JF, Snow ET, Murnane J. Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors. Mutagenesis. 2003 Mar; 18(2):151-8. PMID: 12621071.
      View in: PubMed
    32. Lo AW, Sabatier L, Fouladi B, Pottier G, Ricoul M, Murnane J. DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line. Neoplasia. 2002 Nov-Dec; 4(6):531-8. PMID: 12407447; PMCID: PMC1503667.
    33. Lo AW, Sprung CN, Fouladi B, Pedram M, Sabatier L, Ricoul M, Reynolds GE, Murnane J. Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol Cell Biol. 2002 Jul; 22(13):4836-50. PMID: 12052890; PMCID: PMC133890.
    34. Morales JF, Snow ET, Murnane J. Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents. Mutagenesis. 2002 May; 17(3):193-200. PMID: 11971989.
      View in: PubMed