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John Murnane, PhD

Title(s)Professor Emeritus, Radiation Oncology
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-476-9083
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los AngelePhD06/1980Mircobiology and Immunology
    California State University, NorthridgeBS06/1971Chemistry

    Collapse Overview 
    Collapse Overview
    I am a molecular biologist interested in the role of genomic instability in cancer. Genomic instability is an early step in cancer that promotes tumor cell progression and resistance to therapy. My studies focus on the relationship between DNA repair and telomere loss, and the role of telomere loss in the extensive chromosome instability in cancer cells. Based on our earlier work, I have now developed a high-throughput assay that can detect small molecule inhibitors that target DNA double-strand break repair, telomere loss and chromosome instability, with the goal of identifying new cancer therapies.

    My earlier work was the first to demonstrate the importance of cell cycle regulation in cell survival in response to DNA damage (Nature, 1980), the ability of immortal human cells to maintain telomeres through a telomerase-independent mechanism (EMBO J, 1994), the ability of mammalian cells to repair broken chromosomes through the addition of a new telomere (PNAS, 1999), and the role of telomere loss in chromosome instability in human cancer due to the sensitivity of telomeric regioins to DNA double-strand breaks (Murnane, Reviewed in Cancer Res, 2010).

    Collapse Research 
    Collapse Research Activities and Funding
    Chromosome instability resulting from double-strand breaks near telomeres
    NIH/NCI R01CA120205Jul 6, 2006 - May 31, 2016
    Role: Principal Investigator
    Mechanisms of formation of terminal deletions
    NIH/NIEHS R01ES008427Jan 1, 1997 - May 31, 2009
    Role: Principal Investigator
    TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    NIH/NCI R01CA069044May 15, 1996 - Mar 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Defining the mutation signatures of DNA polymerase ? in cancer genomes. NAR Cancer. 2020 Sep; 2(3):zcaa017. Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI. PMID: 32885167.
      View in: PubMed   Mentions:
    2. Misrepair in Context: TGFß Regulation of DNA Repair. Front Oncol. 2019; 9:799. Liu Q, Lopez K, Murnane J, Humphrey T, Barcellos-Hoff MH. PMID: 31552165.
      View in: PubMed   Mentions:
    3. Subjugation of TGFß Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining. Clin Cancer Res. 2018 12 01; 24(23):6001-6014. Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH. PMID: 30087144.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. The DNA damage response at dysfunctional telomeres, and at interstitial and subtelomeric DNA double-strand breaks. Genes Genet Syst. 2018 Jan 20; 92(3):135-152. Muraki K, Murnane JP. PMID: 29162774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Differences in the recruitment of DNA repair proteins at subtelomeric and interstitial I-SceI endonuclease-induced DNA double-strand breaks. DNA Repair (Amst). 2017 01; 49:1-8. Alcaraz Silva B, Jones TJ, Murnane JP. PMID: 27842255.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Replication Stress and Telomere Dysfunction Are Present in Cultured Human Embryonic Stem Cells. Cytogenet Genome Res. 2015; 146(4):251-60. Janson C, Nyhan K, Murnane JP. PMID: 26517359.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015 Sep 18; 43(16):7911-30. Muraki K, Han L, Miller D, Murnane JP. PMID: 26209132.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. In memoriam: Robert Blair Painter. Radiat Res. 2015 Mar; 183(3):e49-50. Murnane JP. PMID: 25763932.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015 Jan 21; 6:5990. Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. PMID: 25606712.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Analysis of dose distribution and risk of pneumonitis in stereotactic body radiation therapy for centrally located lung tumors: a comparison of robotic radiosurgery, helical tomotherapy and volumetric modulated arc therapy. Technol Cancer Res Treat. 2015 Feb; 14(1):49-60. Kannarunimit D, Descovich M, Garcia A, Chen J, Weinberg V, Mcguinness C, Pinnaduwage D, Murnane J, Gottschalk AR, Yom SS. PMID: 24325136.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiat Res. 2014 Nov; 182(5):573-9. Li Z, Wang H, Wang Y, Murnane JP, Dynan WS. PMID: 25329962.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. DNA-damage response during mitosis induces whole-chromosome missegregation. Cancer Discov. 2014 Nov; 4(11):1281-9. Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA. PMID: 25107667.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    13. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013 Jul; 180(1):17-24. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS. PMID: 23692479.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genet. 2013 Mar; 9(3):e1003386. Muraki K, Han L, Miller D, Murnane JP. PMID: 23555296.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol. 2012; 2:135. Muraki K, Nyhan K, Han L, Murnane JP. PMID: 23061048.
      View in: PubMed   Mentions:
    16. PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. DNA Repair (Amst). 2011 Nov 10; 10(11):1164-73. Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JP. PMID: 21945094.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    17. Telomere dysfunction and chromosome instability. Mutat Res. 2012 Feb 01; 730(1-2):28-36. Murnane JP. PMID: 21575645.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    18. Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst). 2011 May 05; 10(5):536-44. Miller D, Reynolds GE, Mejia R, Stark JM, Murnane JP. PMID: 21466975.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res. 2010 Jun 01; 70(11):4255-9. Murnane JP. PMID: 20484032.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    20. Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line. Mol Cell Biol. 2010 Feb; 30(3):578-89. Kulkarni A, Zschenker O, Reynolds G, Miller D, Murnane JP. PMID: 19933847.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    21. Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line. DNA Repair (Amst). 2009 Aug 06; 8(8):886-900. Zschenker O, Kulkarni A, Miller D, Reynolds GE, Granger-Locatelli M, Pottier G, Sabatier L, Murnane JP. PMID: 19540174.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    22. Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells. DNA Repair (Amst). 2008 Aug 02; 7(8):1233-49. Gao Q, Reynolds GE, Wilcox A, Miller D, Cheung P, Artandi SE, Murnane JP. PMID: 18502190.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    23. Telomeres acquire distinct heterochromatin characteristics during siRNA-induced RNA interference in mouse cells. Curr Biol. 2008 Feb 12; 18(3):183-7. Ho CY, Murnane JP, Yeung AK, Ng HK, Lo AW. PMID: 18261910.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    24. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells. 2007 Dec; 25(12):3085-92. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane JP. PMID: 17823235.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    25. Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. Biochem Biophys Res Commun. 2006 Sep 22; 348(2):728-34. Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K. PMID: 16890201.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    26. Telomeres and chromosome instability. DNA Repair (Amst). 2006 Sep 08; 5(9-10):1082-92. Murnane JP. PMID: 16784900.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    27. Telomeres, chromosome instability and cancer. Nucleic Acids Res. 2006; 34(8):2408-17. Bailey SM, Murnane JP. PMID: 16682448.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    28. Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol. 2006 Mar; 26(5):1865-78. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP. PMID: 16479005.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    29. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006 Mar; 16(3):394-404. Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J, Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A, Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P, Collins C. PMID: 16461635.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    30. The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line. Mol Cancer Res. 2005 Mar; 3(3):139-50. Sabatier L, Ricoul M, Pottier G, Murnane JP. PMID: 15798094.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    31. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays. 2004 Nov; 26(11):1164-74. Murnane JP, Sabatier L. PMID: 15499579.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    32. Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells. Cytogenet Genome Res. 2004; 104(1-4):123-30. Desmaze C, Pirzio LM, Blaise R, Mondello C, Giulotto E, Murnane JP, Sabatier L. PMID: 15162025.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. Applications and technical challenges of fluorescence in situ hybridization in stem cell research. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):68-76. Weier HU, Chu LW, Murnane JP, Weier JF. PMID: 14757416.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    34. Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation. Cytogenet Genome Res. 2004; 104(1-4):87-94. Pirzio LM, Freulet-Marrière MA, Bai Y, Fouladi B, Murnane JP, Sabatier L, Desmaze C. PMID: 15162019.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Mol Cancer Res. 2003 Dec; 1(14):1058-69. Bai Y, Murnane JP. PMID: 14707289.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    36. Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein. Hum Genet. 2003 Sep; 113(4):337-47. Bai Y, Murnane JP. PMID: 12827497.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    37. Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors. Mutagenesis. 2003 Mar; 18(2):151-8. Morales JF, Snow ET, Murnane JP. PMID: 12621071.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line. Neoplasia. 2002 Nov-Dec; 4(6):531-8. Lo AW, Sabatier L, Fouladi B, Pottier G, Ricoul M, Murnane JP. PMID: 12407447.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    39. Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol Cell Biol. 2002 Jul; 22(13):4836-50. Lo AW, Sprung CN, Fouladi B, Pedram M, Sabatier L, Ricoul M, Reynolds GE, Murnane JP. PMID: 12052890.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    40. Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents. Mutagenesis. 2002 May; 17(3):193-200. Morales JF, Snow ET, Murnane JP. PMID: 11971989.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    41. TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines. Genes Chromosomes Cancer. 2001 Mar; 30(3):236-44. Schwartz JL, Jordan R, Liber H, Murnane JP, Evans HH. PMID: 11170280.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    42. The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line. Neoplasia. 2000 Nov-Dec; 2(6):540-54. Fouladi B, Sabatier L, Miller D, Pottier G, Murnane JP. PMID: 11228547.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    43. Telomere instability in a human cancer cell line. Mutat Res. 1999 Oct 19; 429(2):209-23. Sprung CN, Afshar G, Chavez EA, Lansdorp P, Sabatier L, Murnane JP. PMID: 10526206.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    44. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. Gene. 1999 Jun 24; 234(1):161-8. Afshar G, Murnane JP. PMID: 10393250.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    45. Chromosome healing in mouse embryonic stem cells. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6781-6. Sprung CN, Reynolds GE, Jasin M, Murnane JP. PMID: 10359789.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    46. Telomere dynamics in a human cancer cell line. Exp Cell Res. 1999 Feb 25; 247(1):29-37. Sprung CN, Sabatier L, Murnane JP. PMID: 10047445.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. Br J Cancer. 1999 Feb; 79(5-6):744-7. Schwartz JL, Murnane J, Weichselbaum RR. PMID: 10070863.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    48. The influence of interstitial telomeric sequences on chromosome instability in human cells. Cytogenet Cell Genet. 1999; 86(3-4):288-95. Desmaze C, Alberti C, Martins L, Pottier G, Sprung CN, Murnane JP, Sabatier L. PMID: 10575228.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    49. Normal telomere maintenance in immortal ataxia telangiectasia cell lines. Mutat Res. 1997 Oct 06; 379(2):177-84. Sprung CN, Bryan TM, Reddel RR, Murnane JP. PMID: 9357546.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    50. Effect of telomere length on telomeric gene expression. Nucleic Acids Res. 1996 Nov 01; 24(21):4336-40. Sprung CN, Sabatier L, Murnane JP. PMID: 8932391.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. Role of induced genetic instability in the mutagenic effects of chemicals and radiation. Mutat Res. 1996 Jan; 367(1):11-23. Murnane JP. PMID: 8596542.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    52. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7824-8. Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. PMID: 7644499.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    53. Use of a mammalian interspersed repetitive (MIR) element in the coding and processing sequences of mammalian genes. Nucleic Acids Res. 1995 Aug 11; 23(15):2837-9. Murnane JP, Morales JF. PMID: 7659505.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    54. Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts. Biochem Cell Biol. 1995 Jul-Aug; 73(7-8):373-89. Hansell EJ, Frisch SM, Tremble P, Murnane JP, Werb Z. PMID: 8703410.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    55. Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective. Cancer Metastasis Rev. 1995 Mar; 14(1):17-29. Murnane JP. PMID: 7606817.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    56. A role for genomic instability in cellular radioresistance? Cancer Metastasis Rev. 1995 Mar; 14(1):49-58. Morgan WF, Murnane JP. PMID: 7606821.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    57. Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation. Int J Radiat Biol. 1994 Dec; 66(6 Suppl):S77-84. Murnane JP, Zhu Y, Young BR, Christman MF. PMID: 7836856.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    58. Telomere dynamics in an immortal human cell line. EMBO J. 1994 Oct 17; 13(20):4953-62. Murnane JP, Sabatier L, Marder BA, Morgan WF. PMID: 7957062.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    59. Formation of extrachromosomal circular DNA in HeLa cells by nonhomologous recombination. Nucleic Acids Res. 1994 Jul 11; 22(13):2447-52. van Loon N, Miller D, Murnane JP. PMID: 8041604.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    60. Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC). Genomics. 1994 Jan 01; 19(1):130-6. Leonhardt EA, Kapp LN, Young BR, Murnane JP. PMID: 8188213.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    61. Cell checkpoint and radiosensitivity. Nature. 1993 Sep 02; 365(6441):22. Murnane JP, Schwartz JL. PMID: 8361532.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    62. A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus. Genomics. 1993 Jul; 17(1):1-5. Richard CW, Cox DR, Kapp L, Murnane J, Cornelis F, Julier C, Lathrop GM, James MR. PMID: 8406440.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    63. A critical look at the association of human genetic syndromes with sensitivity to ionizing radiation. Semin Cancer Biol. 1993 Apr; 4(2):93-104. Murnane JP, Kapp LN. PMID: 8513152.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    64. Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break. Mol Cell Biol. 1993 Feb; 13(2):977-83. Murnane JP, Yu LC. PMID: 8423817.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    65. Cloning of a candidate gene for ataxia-telangiectasia group D. Am J Hum Genet. 1992 Jul; 51(1):45-54. Kapp LN, Painter RB, Yu LC, van Loon N, Richard CW, James MR, Cox DR, Murnane JP. PMID: 1609804.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    66. The role of recombinational hotspots in genome instability in mammalian cells. Bioessays. 1990 Dec; 12(12):577-81. Murnane JP. PMID: 2080912.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    67. Enhanced expression of procollagenase in ataxia-telangiectasia and xeroderma pigmentosum fibroblasts. In Vitro Cell Dev Biol. 1990 Sep; 26(9):915-22. Aggeler J, Murnane JP. PMID: 2172206.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    68. Recombination events during integration of transfected DNA into normal human cells. Nucleic Acids Res. 1990 May 11; 18(9):2733-8. Murnane JP, Yezzi MJ, Young BR. PMID: 2339059.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    69. Influence of cellular sequences on instability of plasmid integration sites in human cells. Somat Cell Mol Genet. 1990 May; 16(3):195-209. Murnane JP. PMID: 1972815.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    70. Nucleotide sequence analysis of novel junctions near an unstable integrated plasmid in human cells. Gene. 1989 Dec 07; 84(1):201-5. Murnane JP, Young BR. PMID: 2606360.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    71. Association of high rate of recombination with amplification of dominant selectable gene in human cells. Somat Cell Mol Genet. 1988 May; 14(3):273-86. Murnane JP, Yezzi MJ. PMID: 2835823.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    72. Inducible gene expression by DNA rearrangements in human cells. Mol Cell Biol. 1986 Feb; 6(2):549-58. Murnane JP. PMID: 2431271.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    73. Establishment and characterization of a permanent pSV ori--transformed ataxia-telangiectasia cell line. Exp Cell Res. 1985 May; 158(1):119-26. Murnane JP, Fuller LF, Painter RB. PMID: 2987007.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    74. Effect of heat shock on the intracellular distribution of proteins. Radiat Res. 1985 Mar; 101(3):480-90. Murnane JP, Li GC. PMID: 4039070.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    75. Effect of 3-aminobenzamide on sister chromatid exchange frequency in X-irradiated cells. Radiat Res. 1983 Mar; 93(3):567-71. Morgan WF, Schwartz JL, Murnane JP, Wolff S. PMID: 6856757.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    76. Altered protein synthesis in ataxia--telangiectasia fibroblasts. Biochemistry. 1983 Mar 01; 22(5):1217-22. Murnane JP, Painter RB. PMID: 6838849.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    77. Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1960-3. Murnane JP, Painter RB. PMID: 6952246.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    78. Irreparable DNA cross-links and mammalian cell lethality with bifunctional alkylating agents. Chem Biol Interact. 1981 Dec; 38(1):75-86. Murnane JP, Byfield JE. PMID: 7326808.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    79. The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells. Biophys J. 1981 Sep; 35(3):665-76. Murnane JP, Byfield JE, Chen CT, Wang CH. PMID: 7272456.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    80. Mice, men, mustard and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents. Br J Cancer. 1981 May; 43(5):669-83. Byfield JE, Murnane J, Ward JF, Calabro-Jones P, Lynch M, Kulhanian F. PMID: 7248151.
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