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Patrick Ha, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentOtolaryngology
Address550 16th. Street
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityBA1995
    Johns HopkinsMD1999School of Medicine
    Johns HopkinsResidency2005Otolaryngology

    Collapse Overview 
    Collapse Overview
    Patrick Ha, MD is a Professor and the Chief of Head and Neck Oncologic Surgery in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He is also holds the Irwin Mark Jacobs and Joan Klein Jacobs Distinguished Professorship in Head and Neck Surgery. After graduating magna cum laude from Harvard University, he received his medical degree from The Johns Hopkins School of Medicine in Baltimore, Maryland. Dr. Ha completed his one-year internship at The Johns Hopkins Hospital, Baltimore, Maryland, and he also completed an otolaryngology residency from the same institution, followed by advanced training in head and neck surgery at The Johns Hopkins Hospital. Prior to joining UCSF’s Department of OHNS, Dr. Ha was a clinician scientist and an associate professor on the full time faculty at Johns Hopkins working at the Greater Baltimore Medical Center.

    Dr. Ha’s clinical expertise covers the full breadth of head and neck surgery, including a focus on thyroid and parathyroid surgery, as well as endoscopic laser and transoral robotic approaches for throat cancers. His current area of research is focused on the molecular changes occurring in salivary gland adenoid cystic carcinoma, and he has held multiple NIH grants towards this aim, including a current R01 award. In addition, he serves on the editorial board of several journals including Head and Neck and Oral Oncology. He has over 80 published journal articles. While at Johns Hopkins, he held the role of associate residency program director and won several teaching awards for his work with medical students and residents.

    Specialty:
    Head and Neck Oncologic Surgery

    Expertise:
    Head and neck endocrine surgery, robotic surgery, and ablative surgery

    Professional Interests:
    Head and neck cancer, salivary gland, thyroid, neoplasm, adenoid cystic carcinoma, surgery, molecular biology, promoter methylation

    Education and Training:
    • Medical School: Johns Hopkins School of Medicine, Baltimore, Maryland
    • Internship: Johns Hopkins Hospital, Baltimore, Maryland
    • Residency: Johns Hopkins Hospital, Baltimore, Maryland
    • Advance Training: Johns Hopkins Hospital, Baltimore, Maryland – Head and Neck Surgery

    Awards and Honors:
    • 1999 Johns Hopkins School of Medicine - Alpha Omega Alpha Honor Society
    • 2005 Johns Hopkins Department of Otolaryngology - Recipient of the Henkel Chief Resident Teacher of the Year Award
    • 2007 Johns Hopkins Department of Otolaryngology - Recipient of John C. Price Faculty Teaching Award
    • 2011 Johns Hopkins Department of Otolaryngology - Recipient of John C. Price GBMC Faculty Teaching Award
    • 2012-2014 Johns Hopkins Department of Otolaryngology - Baltimore Magazine, voted Top Doctor in Head and Neck Surgical Oncology


    Collapse Research 
    Collapse Research Activities and Funding
    Integrated pathway analysis of altered driver genes in adenoid cystic carcinoma
    NIH/NIDCR R01DE023227Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    array-based screening for the expression and regulation of tumor supressor genes
    NIH/NIDCR R03DE022591Jul 13, 2012 - Jun 30, 2014
    Role: Principal Investigator
    The role of promoter hypermethylation in adenoid cystic carcinoma
    NIH/NIDCR K08DE018463Jul 1, 2007 - Dec 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Rosculet N, Zhou XC, Ha P, Tang M, Levine MA, Neuner G, Califano J. Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma. Head Neck. 2017 Jan 11. PMID: 28075517.
      View in: PubMed
    2. D'Souza G, Westra WH, Wang SJ, van Zante A, Wentz A, Kluz N, Rettig E, Ryan WR, Ha P, Kang H, Bishop J, Quon H, Kiess AP, Richmon JD, Eisele DW, Fakhry C. Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method. JAMA Oncol. 2016 Dec 08. PMID: 27930766.
      View in: PubMed
    3. Wysocki PT, Izumchenko E, Meir J, Ha P, Sidransky D, Brait M. Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016 Oct 04; 7(40):66239-66254. PMID: 27533466.
      View in: PubMed
    4. D'Souza G, Zhang Y, Merritt S, Gold D, Robbins HA, Buckman V, Gerber J, Eisele DW, Ha P, Califano J, Fakhry C. Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer. Oral Oncol. 2016 Sep; 60:90-5. PMID: 27531878.
      View in: PubMed
    5. Kang H, Tan M, Bishop JA, Jones S, Sausen M, Ha P, Agrawal N. Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma. Clin Cancer Res. 2016 Jun 23. PMID: 27340278.
      View in: PubMed
    6. Ling S, Rettig EM, Tan M, Chang X, Wang Z, Brait M, Bishop JA, Fertig EJ, Considine M, Wick MJ, Ha P. Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol. 2016 Jul; 49(1):225-34. PMID: 27212063.
      View in: PubMed
    7. Sobel RH, Blanco R, Ha P, Califano JA, Kumar R, Richmon JD. Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models. Head Neck. 2016 Oct; 38(10):1553-63. PMID: 27152633.
      View in: PubMed
    8. Ha P, Stenman G. Molecular Pathology and Biomarkers. Adv Otorhinolaryngol. 2016; 78:17-24. PMID: 27092959.
      View in: PubMed
    9. Bishop JA, Ha P. Human papillomavirus detection in a "Digital" age. Cancer. 2016 May 15; 122(10):1502-4. PMID: 26990085.
      View in: PubMed
    10. Yin LX, Ha P. Genetic alterations in salivary gland cancers. Cancer. 2016 Jun 15; 122(12):1822-31. PMID: 26928905.
      View in: PubMed
    11. Rettig EM, Talbot C, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig E, Wheelan S, Marchionni L, Considine M, Fakhry C, Papadopoulos N, Kinzler KW, Vogelstein B, Ha P, Agrawal N. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res (Phila). 2016 Apr; 9(4):265-74. PMID: 26862087.
      View in: PubMed
    12. Dixit R, Kemp C, Kulich S, Seethala R, Chiosea S, Ling S, Ha P, Duvvuri U. TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation. Sci Rep. 2015; 5:16657. PMID: 26563938; PMCID: PMC4643216.
      View in: PubMed, PubMed Central
    13. Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha P, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C. Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head Neck. 2016 Apr; 38 Suppl 1:E1501-9. PMID: 26558328.
      View in: PubMed
    14. Park E, Ha P, Eisele DW, Francis HW, Kim YJ. Personal characteristics of residents may predict competency improvement. Laryngoscope. 2016 Aug; 126(8):1746-52. PMID: 26527584.
      View in: PubMed
    15. Li RJ, Zhou XC, Fakhry C, Negrin J, Lee G, Ha P, Blanco R, Saunders J, Califano JA. Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients by a Comprehensive Performance Improvement Intervention. Otolaryngol Head Neck Surg. 2015 Dec; 153(6):927-34. PMID: 26519459.
      View in: PubMed
    16. Wang Z, Ling S, Rettig E, Sobel R, Tan M, Fertig EJ, Considine M, El-Naggar AK, Brait M, Fakhry C, Ha P. Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration. Oral Oncol. 2015 Dec; 51(12):1120-5. PMID: 26490796; PMCID: PMC4663116 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    17. Baxter M, Chan JY, Mydlarz WK, Labruzzo SV, Kiess A, Ha P, Nafi A, Nishant A. Retropharyngeal lymph node involvement in human papillomavirus-associated oropharyngeal squamous cell carcinoma. Laryngoscope. 2015 Nov; 125(11):2503-8. PMID: 26227748.
      View in: PubMed
    18. Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano JA, Eisele DW, Fakhry C, Gourin CG, Ha P, Kang H, Kiess A, Koch WM, Myers JN, Quon H, Richmon JD, Sidransky D, Tufano RP, Westra WH, Bettegowda C, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Agrawal N. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med. 2015 Jun 24; 7(293):293ra104. PMID: 26109104; PMCID: PMC4587492.
      View in: PubMed, PubMed Central
    19. Rettig EM, Tan M, Ling S, Yonescu R, Bishop JA, Fakhry C, Ha P. MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma. Laryngoscope. 2015 Sep; 125(9):E292-9. PMID: 25963073; PMCID: PMC4546892 [Available on 09/01/16].
      View in: PubMed, PubMed Central
    20. Guo T, Qualliotine JR, Ha P, Califano JA, Kim Y, Saunders JR, Blanco RG, D'Souza G, Zhang Z, Chung CH, Kiess A, Gourin CG, Koch W, Richmon JD, Agrawal N, Eisele DW, Fakhry C. Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer. Cancer. 2015 Jun 15; 121(12):1977-84. PMID: 25782027; PMCID: PMC4457566 [Available on 06/15/16].
      View in: PubMed, PubMed Central
    21. Califano JA, Khan Z, Noonan KA, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin CG, Ha P, Fakhry C, Saunders J, Levine M, Tang M, Neuner G, Richmon JD, Blanco R, Agrawal N, Koch WM, Marur S, Weed DT, Serafini P, Borrello I. Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2015 Jan 1; 21(1):30-8. PMID: 25564570; PMCID: PMC4329916 [Available on 01/01/16].
      View in: PubMed, PubMed Central
    22. Benson EM, Hirata RM, Thompson CB, Ha P, Fakhry C, Saunders JR, Califano JA, Arnaoutakis D, Levine M, Tang M, Neuner G, Messing BP, Blanco RG. Pharyngocutaneous fistula after total laryngectomy: a single-institution experience, 2001-2012. Am J Otolaryngol. 2015 Jan-Feb; 36(1):24-31. PMID: 25245411; PMCID: PMC4385716 [Available on 01/01/16].
      View in: PubMed, PubMed Central
    23. Shiwarski DJ, Shao C, Bill A, Kim J, Xiao D, Bertrand CA, Seethala RS, Sano D, Myers JN, Ha P, Grandis J, Gaither LA, Puthenveedu MA, Duvvuri U. To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN. Clin Cancer Res. 2014 Sep 1; 20(17):4673-88. PMID: 24919570; PMCID: PMC4160843.
      View in: PubMed, PubMed Central
    24. Fakhry C, Agrawal N, Califano J, Messing B, Liu J, Saunders J, Ha P, Coquia S, Hamper U, Gillison M, Blanco R. The use of ultrasound in the search for the primary site of unknown primary head and neck squamous cell cancers. Oral Oncol. 2014 Jul; 50(7):640-5. PMID: 24819862.
      View in: PubMed
    25. Bishop JA, Yonescu R, Batista D, Yemelyanova A, Ha P, Westra WH. Mucoepidermoid carcinoma does not harbor transcriptionally active high risk human papillomavirus even in the absence of the MAML2 translocation. Head Neck Pathol. 2014; 8(3):298-302. PMID: 24706055; PMCID: PMC4126915.
      View in: PubMed, PubMed Central
    26. Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha P, Koch WM, Richmon JD, Westra WH, Pai SI. Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncol. 2014 Jun; 50(6):600-4. PMID: 24630260; PMCID: PMC4318229.
      View in: PubMed, PubMed Central
    27. Tan M, Shao C, Bishop JA, Feng Z, Trock BJ, Westra WH, Ha P. Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma. Otolaryngol Head Neck Surg. 2014 May; 150(5):801-7. PMID: 24493792; PMCID: PMC4318231.
      View in: PubMed, PubMed Central
    28. Blanco RG, Califano J, Messing B, Richmon J, Liu J, Quon H, Neuner G, Saunders J, Ha P, Sheth S, Gillison M, Fakhry C. Transcervical ultrasonography is feasible to visualize and evaluate base of tongue cancers. PLoS One. 2014; 9(1):e87565. PMID: 24498138; PMCID: PMC3907536.
      View in: PubMed, PubMed Central
    29. Mydlarz W, Uemura M, Ahn S, Hennessey P, Chang S, Demokan S, Sun W, Shao C, Bishop J, Krosting J, Mambo E, Westra W, Ha P, Sidransky D, Califano J. Clusterin is a gene-specific target of microRNA-21 in head and neck squamous cell carcinoma. Clin Cancer Res. 2014 Feb 15; 20(4):868-77. PMID: 24327270; PMCID: PMC3970211.
      View in: PubMed, PubMed Central
    30. Blanco RG, Fakhry C, Ha P, Ryniak K, Messing B, Califano JA, Saunders JR. Transoral robotic surgery experience in 44 cases. J Laparoendosc Adv Surg Tech A. 2013 Nov; 23(11):900-7. PMID: 24083851.
      View in: PubMed
    31. Chen Z, Chen J, Gu Y, Hu C, Li JL, Lin S, Shen H, Cao C, Gao R, Li J, Ha P, Kaye FJ, Griffin JD, Wu L. Aberrantly activated AREG-EGFR signaling is required for the growth and survival of CRTC1-MAML2 fusion-positive mucoepidermoid carcinoma cells. Oncogene. 2014 Jul 17; 33(29):3869-77. PMID: 23975434.
      View in: PubMed
    32. Brait M, Munari E, LeBron C, Noordhuis MG, Begum S, Michailidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha P, Netto GJ, Sidransky D, Hoque MO. Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. Cell Cycle. 2013 Apr 1; 12(7):1058-70. PMID: 23435205; PMCID: PMC3646862.
      View in: PubMed, PubMed Central
    33. Kumar R, Curry M, Ha P, Blanco R, Califano J, Richmon J. In response to Objective assessment in residency-based training for transoral robotic surgery. Laryngoscope. 2013 May; 123(5):1317. PMID: 23404291.
      View in: PubMed
    34. Sen T, Sen N, Noordhuis MG, Ravi R, Wu TC, Ha P, Sidransky D, Hoque MO. OGDHL is a modifier of AKT-dependent signaling and NF-?B function. PLoS One. 2012; 7(11):e48770. PMID: 23152800; PMCID: PMC3495966.
      View in: PubMed, PubMed Central
    35. Shao C, Tan M, Bishop JA, Liu J, Bai W, Gaykalova DA, Ogawa T, Vikani AR, Agrawal Y, Li RJ, Kim MS, Westra WH, Sidransky D, Califano JA, Ha P. Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma. PLoS One. 2012; 7(11):e48582. PMID: 23144906; PMCID: PMC3492451.
      View in: PubMed, PubMed Central
    36. Junn JC, Kim IA, Zahurak ML, Tan M, Fan KY, Lake ST, Zaboli D, Messing BP, Ulmer K, Harrer KB, Gold D, Ryniak KL, Zinreich ES, Tang M, Levine MA, Blanco RG, Saunders JR, Califano JA, Ha P. Multidisciplinary service utilization pattern by advanced head and neck cancer patients: a single institution study. Int J Otolaryngol. 2012; 2012:628578. PMID: 23118755; PMCID: PMC3483826.
      View in: PubMed, PubMed Central
    37. Blanco RG, Ha P, Califano JA, Fakry C, Richmon J, Saunders JM. Robotic-assisted neck dissection through a pre- and post-auricular hairline incision: preclinical study. J Laparoendosc Adv Surg Tech A. 2012 Oct; 22(8):791-6. PMID: 23039702.
      View in: PubMed
    38. Melvin TA, Eliades SJ, Ha P, Fakhry C, Saunders JM, Califano JA, Blanco RG. Neck dissection through a facelift incision. Laryngoscope. 2012 Dec; 122(12):2700-6. PMID: 23023877; PMCID: PMC3715054.
      View in: PubMed, PubMed Central
    39. Curry M, Malpani A, Li R, Tantillo T, Jog A, Blanco R, Ha P, Califano J, Kumar R, Richmon J. Objective assessment in residency-based training for transoral robotic surgery. Laryngoscope. 2012 Oct; 122(10):2184-92. PMID: 22915265; PMCID: PMC4572744.
      View in: PubMed, PubMed Central
    40. Junn JC, Sciubba JJ, Bishop JA, Zinreich E, Tang M, Levine MA, Palermo RA, Fakhry C, Blanco RG, Saunders JR, Califano JA, Ha P. The effect of amifostine on submandibular gland histology after radiation. Int J Otolaryngol. 2012; 2012:508279. PMID: 22844290; PMCID: PMC3403191.
      View in: PubMed, PubMed Central
    41. Gaykalova D, Vatapalli R, Glazer CA, Bhan S, Shao C, Sidransky D, Ha P, Califano JA. Dose-dependent activation of putative oncogene SBSN by BORIS. PLoS One. 2012; 7(7):e40389. PMID: 22792300; PMCID: PMC3390376.
      View in: PubMed, PubMed Central
    42. Zaboli D, Tan M, Gogineni H, Lake S, Fan K, Zahurak ML, Messing B, Ulmer K, Zinreich ES, Levine MA, Tang M, Pai SI, Blanco RG, Saunders JR, Best SR, Califano JA, Ha P. Hyperfractionated radiotherapy with concurrent cisplatin/5-Fluorouracil for locoregional advanced head and neck cancer: analysis of 105 consecutive patients. Int J Otolaryngol. 2012; 2012:754191. PMID: 22778748; PMCID: PMC3388433.
      View in: PubMed, PubMed Central
    43. Fan KY, Gogineni H, Zaboli D, Lake S, Zahurak ML, Best SR, Levine MA, Tang M, Zinreich ES, Saunders JR, Califano JA, Blanco RG, Pai SI, Messing B, Ha P. Comparison of acute toxicities in two primary chemoradiation regimens in the treatment of advanced head and neck squamous cell carcinoma. Ann Surg Oncol. 2012 Jun; 19(6):1980-7. PMID: 22290566; PMCID: PMC3715048.
      View in: PubMed, PubMed Central
    44. Liu J, Shao C, Tan ML, Mu D, Ferris RL, Ha P. Molecular biology of adenoid cystic carcinoma. Head Neck. 2012 Nov; 34(11):1665-77. PMID: 22006498; PMCID: PMC3262103.
      View in: PubMed, PubMed Central
    45. Bai W, Zhou X, Gao X, Shao C, Califano JA, Ha P. Value of chest CT in the diagnosis and management of tracheobronchial foreign bodies. Pediatr Int. 2011 Aug; 53(4):515-8. PMID: 21129123.
      View in: PubMed
    46. Cho YG, Chang X, Park IS, Yamashita K, Shao C, Ha P, Pai SI, Sidransky D, Kim MS. Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol. 2011 Aug; 39(2):337-44. PMID: 21617854; PMCID: PMC3601031.
      View in: PubMed, PubMed Central
    47. Bhan S, Negi SS, Shao C, Glazer CA, Chuang A, Gaykalova DA, Sun W, Sidransky D, Ha P, Califano JA. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin Cancer Res. 2011 Jul 1; 17(13):4267-76. PMID: 21558405; PMCID: PMC3172963.
      View in: PubMed, PubMed Central
    48. Shao C, Sun W, Tan M, Glazer CA, Bhan S, Zhong X, Fakhry C, Sharma R, Westra WH, Hoque MO, Moskaluk CA, Sidransky D, Califano JA, Ha P. Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clin Cancer Res. 2011 Jul 1; 17(13):4320-30. PMID: 21551254; PMCID: PMC3131484.
      View in: PubMed, PubMed Central
    49. Blanco RG, Ha P, Califano JA, Saunders JM. Transoral robotic surgery of the vocal cord. J Laparoendosc Adv Surg Tech A. 2011 Mar; 21(2):157-9. PMID: 21323600.
      View in: PubMed
    50. Shao C, Bai W, Junn JC, Uemura M, Hennessey PT, Zaboli D, Sidransky D, Califano JA, Ha P. Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma. Oral Oncol. 2011 Apr; 47(4):251-5. PMID: 21324728; PMCID: PMC3065551.
      View in: PubMed, PubMed Central
    51. Best SR, Ha P, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, Messing BP. Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck. 2011 Dec; 33(12):1727-34. PMID: 21246640.
      View in: PubMed
    52. Dasgupta S, Koch R, Westra WH, Califano JA, Ha P, Sidransky D, Koch WM. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep; 3(9):1205-11. PMID: 20660573; PMCID: PMC3040952.
      View in: PubMed, PubMed Central
    53. Durr ML, Mydlarz WK, Shao C, Zahurak ML, Chuang AY, Hoque MO, Westra WH, Liegeois NJ, Califano JA, Sidransky D, Ha P. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010; 5(5):e10828. PMID: 20520817; PMCID: PMC2877085.
      View in: PubMed, PubMed Central
    54. Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha P, Califano JA. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 2010 Feb 1; 16(3):857-66. PMID: 20103683; PMCID: PMC2824550.
      View in: PubMed, PubMed Central
    55. Bai W, Shao C, Sun W, Ha P, Califano JA, Cao Z. Conservative management of transnasal intracranial injury. Am J Otolaryngol. 2011 Mar-Apr; 32(2):165-7. PMID: 20060199.
      View in: PubMed
    56. Durr ML, Agrawal N, Saunders JR, Ha P. Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review. Ear Nose Throat J. 2010 Jan; 89(1):34-7. PMID: 20155698.
      View in: PubMed
    57. Mithani SK, Shao C, Tan M, Smith IM, Califano JA, El-Naggar AK, Ha P. Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS One. 2009; 4(12):e8493. PMID: 20041111; PMCID: PMC2795173.
      View in: PubMed, PubMed Central
    58. Hillel AT, Fakhry C, Pai SI, Williams MF, Blanco RG, Zinreich ES, Levine MA, Westra WH, Saunders JR, Ha P. Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009 Dec; 141(6):737-42. PMID: 19932847.
      View in: PubMed
    59. Lyford-Pike S, Ha P, Jacene HA, Saunders JR, Tufano RP. Limitations of PET/CT in determining need for neck dissection after primary chemoradiation for advanced head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2009; 71(5):251-6. PMID: 19776658.
      View in: PubMed
    60. Durr ML, Saunders JR, Califano JA, Tufano RP, Koch WM, Ha P. Severe hypocalcemia complicating thyroid surgery after Roux-en-Y gastric bypass procedure. Arch Otolaryngol Head Neck Surg. 2009 May; 135(5):507-10. PMID: 19451473.
      View in: PubMed
    61. Agrawal N, Ha P. Management of early-stage laryngeal cancer. Otolaryngol Clin North Am. 2008 Aug; 41(4):757-69, vi-vii. PMID: 18570957.
      View in: PubMed
    62. Glazer CA, Chang SS, Ha P, Califano JA. Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. Oral Oncol. 2009 Apr-May; 45(4-5):440-6. PMID: 18674958.
      View in: PubMed
    63. Ha P, Chang SS, Glazer CA, Califano JA, Sidransky D. Molecular techniques and genetic alterations in head and neck cancer. Oral Oncol. 2009 Apr-May; 45(4-5):335-9. PMID: 18674960; PMCID: PMC2702241.
      View in: PubMed, PubMed Central
    64. Chuang AY, Chuang TC, Chang S, Zhou S, Begum S, Westra WH, Ha P, Koch WM, Califano JA. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Oct; 44(10):915-9. PMID: 18329326; PMCID: PMC3215237.
      View in: PubMed, PubMed Central
    65. Zhao M, Begum S, Ha P, Westra W, Califano J. Downregulation of RAD17 in head and neck cancer. Head Neck. 2008 Jan; 30(1):35-42. PMID: 17657792.
      View in: PubMed
    66. Ha P, Califano JA. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol. 2006 Jan; 7(1):77-82. PMID: 16389187.
      View in: PubMed
    67. Ha P, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, Califano J, Cummings CW, Flint PW, Wahl R, Tufano RP. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Jan; 132(1):12-6. PMID: 16415423.
      View in: PubMed
    68. Ha P, Couch ME, Tufano RP, Koch WM, Califano JA. Short hospital stay after neck dissection. Otolaryngol Head Neck Surg. 2005 Nov; 133(5):677-80. PMID: 16274791.
      View in: PubMed
    69. Kim MM, Clinger JD, Masayesva BG, Ha P, Zahurak ML, Westra WH, Califano JA. Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res. 2004 Dec 15; 10(24):8512-5. PMID: 15623632.
      View in: PubMed
    70. Sirianni N, Ha P, Oelke M, Califano J, Gooding W, Westra W, Whiteside TL, Koch WM, Schneck JP, DeLeo A, Ferris RL. Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004 Oct 15; 10(20):6929-37. PMID: 15501971.
      View in: PubMed
    71. Ha P, Califano JA. The role of human papillomavirus in oral carcinogenesis. Crit Rev Oral Biol Med. 2004; 15(4):188-96. PMID: 15284184.
      View in: PubMed
    72. Masayesva BG, Ha P, Garrett-Mayer E, Pilkington T, Mao R, Pevsner J, Speed T, Benoit N, Moon CS, Sidransky D, Westra WH, Califano J. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc Natl Acad Sci U S A. 2004 Jun 8; 101(23):8715-20. PMID: 15155901; PMCID: PMC423261.
      View in: PubMed, PubMed Central
    73. Tong BC, Dhir K, Ha P, Westra WH, Alter BP, Sidransky D, Koch WM, Califano JA. Use of single nucleotide polymorphism arrays to identify a novel region of loss on chromosome 6q in squamous cell carcinomas of the oral cavity. Head Neck. 2004 Apr; 26(4):345-52. PMID: 15054738.
      View in: PubMed
    74. Goldenberg D, Harden S, Masayesva BG, Ha P, Benoit N, Westra WH, Koch WM, Sidransky D, Califano JA. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2004 Jan; 130(1):39-44. PMID: 14732766.
      View in: PubMed
    75. Ha P, Benoit NE, Yochem R, Sciubba J, Zahurak M, Sidransky D, Pevsner J, Westra WH, Califano J. A transcriptional progression model for head and neck cancer. Clin Cancer Res. 2003 Aug 1; 9(8):3058-64. PMID: 12912957.
      View in: PubMed
    76. Tong BC, Ha P, Dhir K, Xing M, Westra WH, Sidransky D, Califano JA. Mitochondrial DNA alterations in thyroid cancer. J Surg Oncol. 2003 Mar; 82(3):170-3. PMID: 12619060.
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    77. Ha P, Califano JA. The molecular biology of mucosal field cancerization of the head and neck. Crit Rev Oral Biol Med. 2003; 14(5):363-9. PMID: 14530304.
      View in: PubMed
    78. Ha P, Pilkington TA, Westra WH, Sciubba J, Sidransky D, Califano JA. Progression of microsatellite instability from premalignant lesions to tumors of the head and neck. Int J Cancer. 2002 Dec 20; 102(6):615-7. PMID: 12448003.
      View in: PubMed
    79. Ha P, Califano JA. The molecular biology of laryngeal cancer. Otolaryngol Clin North Am. 2002 Oct; 35(5):993-1012. PMID: 12587244.
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    80. Ha P, Tong BC, Westra WH, Sanchez-Cespedes M, Parrella P, Zahurak M, Sidransky D, Califano JA. Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. Clin Cancer Res. 2002 Jul; 8(7):2260-5. PMID: 12114429.
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    81. Capone RB, Ha P, Westra WH, Pilkington TM, Sciubba JJ, Koch WM, Cummings CW. Oncocytic neoplasms of the parotid gland: a 16-year institutional review. Otolaryngol Head Neck Surg. 2002 Jun; 126(6):657-62. PMID: 12087334.
      View in: PubMed
    82. Ha P, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002 May; 8(5):1203-9. PMID: 12006539.
      View in: PubMed
    83. Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E. BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res. 2000 Nov 1; 60(21):6171-7. PMID: 11085541.
      View in: PubMed
    84. Ha P, Eisele DW, Frassica FJ, Zahurak ML, McCarthy EF. Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope. 1999 Jun; 109(6):964-9. PMID: 10369291.
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    85. Hruban RH, Petersen GM, Ha P, Kern SE. Genetics of pancreatic cancer. From genes to families. Surg Oncol Clin N Am. 1998 Jan; 7(1):1-23. PMID: 9443984.
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    86. Patrick HA, Paul R, Nalder S. A health situation analysis in Trinidad and Tobago, 1990. The local health systems approach. West Indian Med J. 1991 Jun; 40(2):105-8. PMID: 1897220.
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