Joshua Berke, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
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    Collapse Overview
    Josh Berke's laboratory at UCSF investigates brain mechanisms involved in learning, motivation and decision-making, and how these mechanisms go awry in disorders such as drug addiction, Parkinson's Disease and Huntington's Disease. (see www.berkelab.org). He is also Director of the Alcohol and Addiction Research Group, and holds the Rudi Schmid Distinguished Professorship in Neurology.

    Collapse Research 
    Collapse Research Activities and Funding
    Assessment of Striatal Indirect Pathway Function in Normal and HD Rats
    CHDI May 1, 2018 - Apr 30, 2021
    Role: Principal Investigator
    Dopaminergic mechanisms for motivation and reinforcement learning
    NIH/NIDA R01DA045783Apr 15, 2018 - Mar 31, 2023
    Dopaminergic mechanisms for motivation and reinforcement learning
    NIH/NIDA R01DA045783Apr 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Carbon Thread Arrays for High Resolution Multi-Modal Analysis of Microcircuits
    NIH/NINDS U01NS094375Sep 30, 2015 - Jul 31, 2018
    Role: Co-Principal Investigator
    Basal Ganglia Pathways for Stopping and Switching
    NIH/NIMH R01MH101697Sep 26, 2013 - Jul 31, 2018
    Role: Principal Investigator
    Striatal Microcircuits: Regulation and Function
    NIH/NINDS R01NS078435Jun 15, 2012 - May 31, 2017
    Role: Principal Investigator
    Reinforcement Learning and Striatal Patch/Matrix Architecture
    NIH/NIDA R21DA032259Jun 1, 2011 - May 31, 2014
    Role: Principal Investigator
    Combining optogenetics and electrophysiology to dissect accumbens microcircuits
    NIH/NIMH R21MH093888May 20, 2011 - Apr 30, 2014
    Role: Principal Investigator
    Multiple Memory Systems in Action Selection
    NIH/NIDA R01DA014318Aug 1, 2001 - Jul 31, 2007
    Role: Principal Investigator
    NIH/NIMH F32MH012908Sep 29, 2000
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Berke JD. What does dopamine mean? Nat Neurosci. 2018 Jun; 21(6):787-793. PMID: 29760524.
      View in: PubMed
    2. Mirzaei A, Kumar A, Leventhal D, Mallet N, Aertsen A, Berke J, Schmidt R. Sensorimotor Processing in the Basal Ganglia Leads to Transient Beta Oscillations during Behavior. J Neurosci. 2017 Nov 15; 37(46):11220-11232. PMID: 29038241.
      View in: PubMed
    3. Schmidt R, Berke JD. A Pause-then-Cancel model of stopping: evidence from basal ganglia neurophysiology. Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19; 372(1718). PMID: 28242736.
      View in: PubMed
    4. Howe WM, Gritton HJ, Lusk NA, Roberts EA, Hetrick VL, Berke JD, Sarter M. Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection. J Neurosci. 2017 03 22; 37(12):3215-3230. PMID: 28213446.
      View in: PubMed
    5. Angulo-Garcia D, Berke JD, Torcini A. Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons. PLoS Comput Biol. 2016 Feb; 12(2):e1004778. PMID: 26915024; PMCID: PMC4767417.
    6. Mallet N, Schmidt R, Leventhal D, Chen F, Amer N, Boraud T, Berke JD. Arkypallidal Cells Send a Stop Signal to Striatum. Neuron. 2016 Jan 20; 89(2):308-16. PMID: 26777273.
      View in: PubMed
    7. Gritton HJ, Howe WM, Mallory CS, Hetrick VL, Berke JD, Sarter M. Cortical cholinergic signaling controls the detection of cues. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1089-97. PMID: 26787867; PMCID: PMC4776505.
    8. Hamid AA, Pettibone JR, Mabrouk OS, Hetrick VL, Schmidt R, Vander Weele CM, Kennedy RT, Aragona BJ, Berke JD. Mesolimbic dopamine signals the value of work. Nat Neurosci. 2016 Jan; 19(1):117-26. PMID: 26595651; PMCID: PMC4696912.
    9. Wu F, Tien LW, Chen F, Berke J, Kaplan DL, Yoon E. .Silk-backed structural optimization of high-density flexible intracortical neural probes. IEEE Journal on Microelectromechanical Systems. 2015; 24:62-69.
    10. Gittis AH, Berke JD, Bevan MD, Chan CS, Mallet N, Morrow MM, Schmidt R. New roles for the external globus pallidus in basal ganglia circuits and behavior. J Neurosci. 2014 Nov 12; 34(46):15178-83. PMID: 25392486; PMCID: PMC4228126.
    11. Leventhal DK, Stoetzner C, Abraham R, Pettibone J, DeMarco K, Berke JD. Dissociable effects of dopamine on learning and performance within sensorimotor striatum. Basal Ganglia. 2014 Jun 01; 4(2):43-54. PMID: 24949283.
      View in: PubMed
    12. Freeze BS, Kravitz AV, Hammack N, Berke JD, Kreitzer AC. Control of basal ganglia output by direct and indirect pathway projection neurons. J Neurosci. 2013 Nov 20; 33(47):18531-9. PMID: 24259575; PMCID: PMC3834057.
    13. Schmidt R, Leventhal DK, Mallet N, Chen F, Berke JD. Canceling actions involves a race between basal ganglia pathways. Nat Neurosci. 2013 Aug; 16(8):1118-24. PMID: 23852117; PMCID: PMC3733500.
    14. Leventhal DK, Gage GJ, Schmidt R, Pettibone JR, Case AC, Berke JD. Basal ganglia beta oscillations accompany cue utilization. Neuron. 2012 Feb 09; 73(3):523-36. PMID: 22325204; PMCID: PMC3463873.
    15. Gittis AH, Leventhal DK, Fensterheim BA, Pettibone JR, Berke JD, Kreitzer AC. Selective inhibition of striatal fast-spiking interneurons causes dyskinesias. J Neurosci. 2011 Nov 02; 31(44):15727-31. PMID: 22049415; PMCID: PMC3226784.
    16. Kreitzer AC, Berke JD. Investigating striatal function through cell-type-specific manipulations. Neuroscience. 2011 Dec 15; 198:19-26. PMID: 21867745; PMCID: PMC3221791.
    17. Klaus A, Planert H, Hjorth JJ, Berke JD, Silberberg G, Kotaleski JH. Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact. Front Syst Neurosci. 2011; 5:57. PMID: 21808608; PMCID: PMC3139213.
    18. Berke JD. Functional properties of striatal fast-spiking interneurons. Front Syst Neurosci. 2011; 5:45. PMID: 21743805; PMCID: PMC3121016.
    19. van der Meer MA, Kalenscher T, Lansink CS, Pennartz CM, Berke JD, Redish AD. Integrating early results on ventral striatal gamma oscillations in the rat. Front Neurosci. 2010; 4:300. PMID: 21350600; PMCID: PMC3039412.
    20. Gage GJ, Stoetzner CR, Wiltschko AB, Berke JD. Selective activation of striatal fast-spiking interneurons during choice execution. Neuron. 2010 Aug 12; 67(3):466-79. PMID: 20696383; PMCID: PMC2920892.
    21. Chang CH, Berke JD, Maren S. Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats. PLoS One. 2010 Aug 05; 5(8):e11971. PMID: 20700483; PMCID: PMC2916837.
    22. Feldt S, Wang JX, Hetrick VL, Berke JD, Zochowski M. Memory formation: from network structure to neural dynamics. Philos Trans A Math Phys Eng Sci. 2010 May 13; 368(1918):2251-67. PMID: 20368245.
      View in: PubMed
    23. Lau T, Gage GJ, Berke JD, Zochowski M. Local dynamics of gap-junction-coupled interneuron networks. Phys Biol. 2010 Mar 12; 7:16015. PMID: 20228446; PMCID: PMC2896010.
    24. Wiltschko AB, Pettibone JR, Berke JD. Opposite effects of stimulant and antipsychotic drugs on striatal fast-spiking interneurons. Neuropsychopharmacology. 2010 May; 35(6):1261-70. PMID: 20090670; PMCID: PMC3055348.
    25. Stoetzner CR, Pettibone JR, Berke JD. State-dependent plasticity of the corticostriatal pathway. Neuroscience. 2010 Feb 17; 165(4):1013-8. PMID: 19932155; PMCID: PMC2814943.
    26. Pennartz CM, Berke JD, Graybiel AM, Ito R, Lansink CS, van der Meer M, Redish AD, Smith KS, Voorn P. Corticostriatal Interactions during Learning, Memory Processing, and Decision Making. J Neurosci. 2009 Oct 14; 29(41):12831-8. PMID: 19828796; PMCID: PMC3849625.
    27. Berke JD. Striatal interneurons and reward prediction errors (Commentary on Apicella et al.). Eur J Neurosci. 2009 Aug; 30(3):514. PMID: 19686434.
      View in: PubMed
    28. Berke JD. Fast oscillations in cortical-striatal networks switch frequency following rewarding events and stimulant drugs. Eur J Neurosci. 2009 Sep; 30(5):848-59. PMID: 19659455; PMCID: PMC2778242.
    29. Feldt S, Waddell J, Hetrick VL, Berke JD, Zochowski M. Functional clustering algorithm for the analysis of dynamic network data. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 May; 79(5 Pt 2):056104. PMID: 19518518; PMCID: PMC2814878.
    30. Berke JD, Breck JT, Eichenbaum H. Striatal versus hippocampal representations during win-stay maze performance. J Neurophysiol. 2009 Mar; 101(3):1575-87. PMID: 19144741; PMCID: PMC2666400.
    31. Berke JD. Uncoordinated firing rate changes of striatal fast-spiking interneurons during behavioral task performance. J Neurosci. 2008 Oct 01; 28(40):10075-80. PMID: 18829965; PMCID: PMC2613805.
    32. Wiltschko AB, Gage GJ, Berke JD. Wavelet filtering before spike detection preserves waveform shape and enhances single-unit discrimination. J Neurosci Methods. 2008 Aug 15; 173(1):34-40. PMID: 18597853; PMCID: PMC2602872.
    33. Berke JD, Hetrick V, Breck J, Greene RW. Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments. Hippocampus. 2008; 18(5):519-29. PMID: 18398852.
      View in: PubMed
    34. Sgambato-Faure V, Xiong Y, Berke JD, Hyman SE, Strehler EE. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Biochem Biophys Res Commun. 2006 May 05; 343(2):630-7. PMID: 16554037; PMCID: PMC3873836.
    35. Berke JD, Okatan M, Skurski J, Eichenbaum HB. Oscillatory entrainment of striatal neurons in freely moving rats. Neuron. 2004 Sep 16; 43(6):883-96. PMID: 15363398.
      View in: PubMed
    36. Berke JD. Analysis of mRNA expression in striatal tissue by differential display polymerase chain reaction. Methods Mol Med. 2003; 79:193-209. PMID: 12506698.
      View in: PubMed
    37. Berke JD. Learning and memory mechanisms involved in compulsive drug use and relapse. Methods Mol Med. 2003; 79:75-101. PMID: 12506691.
      View in: PubMed
    38. Berke JD, Eichenbaum HB. Drug addiction and the hippocampus. Science. 2001 Nov 09; 294(5545):1235. PMID: 11701892.
      View in: PubMed
    39. Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE. Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin. Neuron. 2001 Oct 25; 32(2):277-87. PMID: 11683997.
      View in: PubMed
    40. Berke JD, Hyman SE. Addiction, dopamine, and the molecular mechanisms of memory. Neuron. 2000 Mar; 25(3):515-32. PMID: 10774721.
      View in: PubMed
    41. Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR. A complex program of striatal gene expression induced by dopaminergic stimulation. J Neurosci. 1998 Jul 15; 18(14):5301-10. PMID: 9651213.
      View in: PubMed
    42. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997 Sep; 19(3):591-611. PMID: 9331351.
      View in: PubMed
    43. Genova L, Berke J, Hyman SE. Molecular adaptations to psychostimulants in striatal neurons: toward a pathophysiology of addiction. Neurobiol Dis. 1997; 4(3-4):239-46. PMID: 9361300.
      View in: PubMed
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