Loren Frank, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
ORCID ORCID Icon0000-0002-1752-5677 Additional info
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    Research Overview

    The ability to store experiences and then use them to guide behavior is one of the most remarkable abilities of the brain. Our goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. In particular, our laboratory focuses on the circuitry of the hippocampus and anatomically related regions. We use a combination of techniques, including large scale multielectrode recording, targeted optogenetic interventions and behavioral manipulations of awake, behaving animals to understand how the brain learns and remembers.

    Learning in the Hippocampus and Cortex

    Previous studies have shown that neurons throughout the hippocampal formation show place specific firing patterns, where a given neuron is active only in a subregion of the animal's environment. Most of these studies focused on describing patterns of activity during well learned tasks, and we therefore know little about neural processing during learning. We have developed a spatial alternation task that animals can learn over the course of a few days of exposure. We have shown that rapid learning in this task requires an intact hippocampus, and thus this task provides a powerful paradigm for examining the relationship between dynamic patterns of neural activity and changes in behavior.

    Although the hippocampus is essential for spatial learning, storing and retrieving new information requires complex networks spread throughout the brain. One prominent hypothesis states that learning takes place first in the hippocampus and over time information is transferred to neocortical regions in a process known as consolidation. We are therefore recording both in the hippocampus and in downstream areas to understand how hippocampal and cortical circuits could support learning, consolidation and memory guided behavior.

    These studies continue to provide important new insights into how the brain changes as animals learn and how memory retrieval might occur, but these insights are fundamentally correlational in nature. We have therefore been developing and apply new techniques, including optogenetic manipulations, to take these correlational hypothesis and turn them into causal understanding. We can now express optically activated channels in specific subpopulations of neurons in the rat hippocampus and activate these channels with an implanted fiber optic. We have also combined this optical activation with large scale multielectrode recording, allowing us to manipulate the circuit and record the results both locally and in more distant brain regions.
    Anatomical Organization of the Hippocampus

    The hippocampal formation has a unique anatomical organization in that the connectivity between adjacent hippocampal regions is almost exclusively unidirectional. The majority of neocortical input to the hippocampus comes in through the superficial layers of the entorhinal cortex and connections proceed through the dentate gyrus, to CA3 and on to CA1 (the hippocampus proper), and then to the subiculum. Nearly all neocortically bound outputs from the hippocampus originate in CA1 and the subiculum and target cells in the deep layers of the entorhinal cortex, which projects both to numerous neocortical regions as well as to back to the superficial layers of the entorhinal cortex. Our research uses that organization to compare patterns of activity across regions and to use the similarities and differences among the patterns to identify the transformations that occur in the hippocampal circuit.

    An Animal Model for Hippocampal Function

    Numerous researchers have shown that a human without a hippocampus is unable to form new memories of facts or events. In rodents these same structures play an essential role in animal's abilities to learn about and remember complex associations, including tasks where the animal must learn and remember information about a set of spatial cues in order to navigate through an environment. Event/fact memory in humans and spatial memory in rodents both require learning complex relationships, and that parallel strongly suggests that qualitatively similar processing occurs in the human and the rat hippocampus.

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    Collapse Research Activities and Funding
    Modular systems for large scale, long lasting measurements of brain activity
    NIH/NINDS UF1NS107667Sep 30, 2018 - Sep 29, 2021
    Role: Principal Investigator
    Computational and circuit mechanisms for information transmission in the brain
    NIH/NINDS U01NS094288Sep 30, 2015 - Aug 31, 2019
    Role: Co-Principal Investigator
    Modular systems for measuring and manipulating brain activity
    NIH/NINDS U01NS090537Sep 30, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Real-time analysis of memories and decisions
    NIH/NIMH R01MH105174Aug 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    The role of cholinergic modulation in hippocampal information processing
    NIH/NIMH R21MH097158Apr 15, 2013 - Mar 31, 2015
    Role: Principal Investigator
    The role of hippocampal replay in memory formation and retrieval
    NIH/NIMH R01MH090188Feb 8, 2011 - Jan 31, 2016
    Role: Principal Investigator
    Learning in neural circuits: applied optogenetics in non-genetic models
    NIH/NINDS RC2NS069350Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Dynamic Analysis of Neural Plasticity in the Hippocampal Circuit
    NIH/NIMH R01MH080283Jun 1, 2007 - Sep 29, 2011
    Role: Principal Investigator
    Variation as a Neural Code
    NIH/NIMH P50MH077970Sep 8, 2006 - Aug 31, 2012
    Role: Co-Investigator
    Adaptive Analysis of Neural Receptive Field Dynamics
    NIH/NIMH F32MH065108Mar 15, 2002 - Jun 30, 2003
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Memory alone does not account for the speed of learning of a simple spatial alternation task in rats. J Neurosci. 2020 Aug 04. Kastner DB, Gillespie AK, Dayan P, Frank LM. PMID: 32753514.
      View in: PubMed   Mentions:    Fields:    
    2. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Mol Psychiatry. 2020 Mar 06. Miller EA, Kastner DB, Grzybowski MN, Dwinell MR, Geurts AM, Frank LM. PMID: 32144356.
      View in: PubMed   Mentions:    Fields:    
    3. Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus. Cell. 2020 02 06; 180(3):552-567.e25. Kay K, Chung JE, Sosa M, Schor JS, Karlsson MP, Larkin MC, Liu DF, Frank LM. PMID: 32004462.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Dorsal and Ventral Hippocampal Sharp-Wave Ripples Activate Distinct Nucleus Accumbens Networks. Neuron. 2020 02 19; 105(4):725-741.e8. Sosa M, Joo HR, Frank LM. PMID: 31864947.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model. Cell Rep. 2019 11 19; 29(8):2123-2133.e4. Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y. PMID: 31747587.
      View in: PubMed   Mentions: 2     Fields:    
    6. A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain. J Neural Eng. 2019 10 29; 16(6):066021. Joo HR, Fan JL, Chen S, Pebbles JA, Liang H, Chung JE, Yorita AM, Tooker AC, Tolosa VM, Geaghan-Breiner C, Roumis DK, Liu DF, Haque R, Frank LM. PMID: 31216526.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community. J Neurosci. 2019 10 16; 39(42):8275-8284. Litvina E, Adams A, Barth A, Bruchez M, Carson J, Chung JE, Dupre KB, Frank LM, Gates KM, Harris KM, Joo H, William Lichtman J, Ramos KM, Sejnowski T, Trimmer JS, White S, Koroshetz W. PMID: 31619497.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Chronic Implantation of Multiple Flexible Polymer Electrode Arrays. J Vis Exp. 2019 10 04; (152). Chung JE, Joo HR, Smyth CN, Fan JL, Geaghan-Breiner C, Liang H, Liu DF, Roumis D, Chen S, Lee KY, Pebbles JA, Tooker AC, Tolosa VM, Frank LM. PMID: 31633681.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Efficient Decoding of Multi-Dimensional Signals From Population Spiking Activity Using a Gaussian Mixture Particle Filter. IEEE Trans Biomed Eng. 2019 12; 66(12):3486-3498. Yousefi A, Gillespie AK, Guidera JA, Karlsson M, Frank LM, Eden UT. PMID: 30932819.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Three brain states in the hippocampus and cortex. Hippocampus. 2019 03; 29(3):184-238. Kay K, Frank LM. PMID: 29722465.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    11. The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation. Nat Rev Neurosci. 2018 12; 19(12):744-757. Joo HR, Frank LM. PMID: 30356103.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    12. High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays. Neuron. 2019 01 02; 101(1):21-31.e5. Chung JE, Joo HR, Fan JL, Liu DF, Barnett AH, Chen S, Geaghan-Breiner C, Karlsson MP, Karlsson M, Lee KY, Liang H, Magland JF, Pebbles JA, Tooker AC, Greengard LF, Tolosa VM, Frank LM. PMID: 30502044.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    13. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. Are We There Yet? Identification of Reward-Selective Cells in the Hippocampus. Neuron. 2018 07 11; 99(1):7-10. Sosa M, Frank LM. PMID: 30001513.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    15. A Comparison Study of Point-Process Filter and Deep Learning Performance in Estimating Rat Position Using an Ensemble of Place Cells. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:4732-4735. Rezaei MR, Gillespie AK, Guidera JA, Nazari B, Sadri S, Frank LM, Eden UT, Yousefi A. PMID: 30441406.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Specific hippocampal representations are linked to generalized cortical representations in memory. Nat Commun. 2018 06 07; 9(1):2209. Yu JY, Liu DF, Loback A, Grossrubatscher I, Frank LM. PMID: 29880860.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    17. International Neuroscience Initiatives through the Lens of High-Performance Computing. Computer. 2018 Apr 1; 51(4):50-59. Kristofer E. Bouchard, James B. Aimone, Miyoung Chun, Thomas Dean, Michael Denker, Markus Diesmann, David D. Donofrio, Loren M. Frank, Narayanan Kasthuri, Christof Koch, Oliver Rubel, Horst D. Simon, F.T. Sommer, Prabhat. .
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    18. Characterizing Complex, Multi-Scale Neural Phenomena Using State-Space Models. Dynamic Neuroscience. 2018 Jan 1; 29-52. Uri T. Eden, Loren M. Frank, Long Tao. .
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    19. Neural Activity Patterns Underlying Spatial Coding in the Hippocampus. Curr Top Behav Neurosci. 2018; 37:43-100. Sosa M, Gillespie AK, Frank LM. PMID: 27885550.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Hippocampal-Prefrontal Reactivation during Learning Is Stronger in Awake Compared with Sleep States. J Neurosci. 2017 12 06; 37(49):11789-11805. Tang W, Shin JD, Frank LM, Jadhav SP. PMID: 29089440.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    21. A Fully Automated Approach to Spike Sorting. Neuron. 2017 Sep 13; 95(6):1381-1394.e6. Chung JE, Magland JF, Barnett AH, Tolosa VM, Tooker AC, Lee KY, Shah KG, Felix SH, Frank LM, Greengard LF. PMID: 28910621.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    22. Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility. Elife. 2017 08 03; 6. Yu JY, Kay K, Liu DF, Grossrubatscher I, Loback A, Sosa M, Chung JE, Karlsson MP, Larkin MC, Frank LM. PMID: 28826483.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. A cortical-hippocampal-cortical loop of information processing during memory consolidation. Nat Neurosci. 2017 02; 20(2):251-259. Rothschild G, Eban E, Frank LM. PMID: 27941790.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    24. Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making. Neuron. 2016 Dec 07; 92(5):975-982. Papale AE, Zielinski MC, Frank LM, Jadhav SP, Redish AD. PMID: 27866796.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    25. High-Performance Computing in Neuroscience for Data-Driven Discovery, Integration, and Dissemination. Neuron. 2016 Nov 02; 92(3):628-631. Bouchard KE, Aimone JB, Chun M, Dean T, Denker M, Diesmann M, Donofrio DD, Frank LM, Kasthuri N, Koch C, Ruebel O, Simon HD, Sommer FT. PMID: 27810006.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Cover Image, Volume 26, Issue 10. Hippocampus. 2016 Oct 1; 26(10):c1-c1. Howard Eichenbaum, David G. Amaral, Elizabeth A. Buffalo, György Buzsáki, Neal Cohen, Lila Davachi, Loren Frank, Stephan Heckers, Richard G. M. Morris, Edvard I. Moser, Lynn Nadel, John O'Keefe, Alison Preston, Charan Ranganath, Alcino Silva, Menno Witter. .
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    27. Rapid classification of hippocampal replay content for real-time applications. J Neurophysiol. 2016 11 01; 116(5):2221-2235. Deng X, Liu DF, Karlsson MP, Frank LM, Eden UT. PMID: 27535369.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    28. Hippocampus at 25. Hippocampus. 2016 10; 26(10):1238-49. Eichenbaum H, Amaral DG, Buffalo EA, Buzsáki G, Cohen N, Davachi L, Frank L, Heckers S, Morris RG, Moser EI, Nadel L, O'Keefe J, Preston A, Ranganath C, Silva A, Witter M. PMID: 27399159.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    29. Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples. Neuron. 2016 05 18; 90(4):740-51. Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y. PMID: 27161522.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    30. Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events. Neuron. 2016 Apr 06; 90(1):113-27. Jadhav SP, Rothschild G, Roumis DK, Frank LM. PMID: 26971950.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    31. A hippocampal network for spatial coding during immobility and sleep. Nature. 2016 Mar 10; 531(7593):185-90. Kay K, Sosa M, Chung JE, Karlsson MP, Larkin MC, Frank LM. PMID: 26934224.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    32. Decoding position from multiunit activity using a marked point process filter. BMC Neuroscience. 2015 Dec 1; 16(Suppl 1):p66. Xinyi Deng, Daniel F Liu, Kenneth Kay, Loren M Frank, Uri T Eden. .
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    33. Hippocampal sharp-wave ripples in waking and sleeping states. Curr Opin Neurobiol. 2015 Dec; 35:6-12. Roumis DK, Frank LM. PMID: 26011627.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    34. Clusterless Decoding of Position from Multiunit Activity Using a Marked Point Process Filter. Neural Comput. 2015 Jul; 27(7):1438-60. Deng X, Liu DF, Kay K, Frank LM, Eden UT. PMID: 25973549.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. Dynamic Hippocampal Circuits Support Learning- and Memory-Guided Behaviors. Cold Spring Harb Symp Quant Biol. 2014; 79:51-8. Anderson EB, Grossrubatscher I, Frank L. PMID: 25922478.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    36. Reconceiving the hippocampal map as a topological template. Elife. 2014 Aug 20; 3:e03476. Dabaghian Y, Brandt VL, Frank LM. PMID: 25141375.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    37. Hippocampal output area CA1 broadcasts a generalized novelty signal during an object-place recognition task. Hippocampus. 2014 Jul; 24(7):773-83. Larkin MC, Lykken C, Tye LD, Wickelgren JG, Frank LM. PMID: 24596296.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    38. Hippocampal-cortical interaction in decision making. Neurobiol Learn Mem. 2015 Jan; 117:34-41. Yu JY, Frank LM. PMID: 24530374.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    39. Towards a large-scale recording system: demonstration of polymer-based penetrating array for chronic neural recording. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:6830-3. Tooker A, Liu D, Anderson EB, Felix S, Shah KG, Lee KY, Chung JE, Pannu S, Frank L, Tolosa V. PMID: 25571565.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    40. Memory Replay in the Hippocampus. Space,Time and Memory in the Hippocampal Formation. 2014 Jan 1; 351-371. Shantanu P. Jadhav, Loren M. Frank. .
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    41. Insertion of flexible neural probes using rigid stiffeners attached with biodissolvable adhesive. J Vis Exp. 2013 Sep 27; (79):e50609. Felix SH, Shah KG, Tolosa VM, Sheth HJ, Tooker AC, Delima TL, Jadhav SP, Frank LM, Pannu SS. PMID: 24121443.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    42. Rapid and continuous modulation of hippocampal network state during exploration of new places. PLoS One. 2013; 8(9):e73114. Kemere C, Carr MF, Karlsson MP, Frank LM. PMID: 24023818.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    43. Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task. Neuron. 2013 Mar 20; 77(6):1163-73. Singer AC, Carr MF, Karlsson MP, Frank LM. PMID: 23522050.
      View in: PubMed   Mentions: 69     Fields:    Translation:Animals
    44. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 2012 Dec 20; 492(7429):428-32. Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K. PMID: 23160494.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    45. Transient slow gamma synchrony underlies hippocampal memory replay. Neuron. 2012 Aug 23; 75(4):700-13. Carr MF, Karlsson MP, Frank LM. PMID: 22920260.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    46. Spatial information outflow from the hippocampal circuit: distributed spatial coding and phase precession in the subiculum. J Neurosci. 2012 Aug 22; 32(34):11539-58. Kim SM, Ganguli S, Frank LM. PMID: 22915100.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    47. Awake hippocampal sharp-wave ripples support spatial memory. Science. 2012 Jun 15; 336(6087):1454-8. Jadhav SP, Kemere C, German PW, Frank LM. PMID: 22555434.
      View in: PubMed   Mentions: 196     Fields:    Translation:Animals
    48. A single microcircuit with multiple functions: state dependent information processing in the hippocampus. Curr Opin Neurobiol. 2012 Aug; 22(4):704-8. Carr MF, Frank LM. PMID: 22480878.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    49. Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nat Neurosci. 2011 Dec 04; 15(1):163-70. Anikeeva P, Andalman AS, Witten I, Warden M, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K. PMID: 22138641.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    50. The structure of networks that produce the transformation from grid cells to place cells. Neuroscience. 2011 Dec 01; 197:293-306. Cheng S, Frank LM. PMID: 21963867.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    51. Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements. J Neurosci. 2011 Sep 07; 31(36):12716-26. Li JX, Medina JF, Frank LM, Lisberger SG. PMID: 21900551.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    52. Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval. Nat Neurosci. 2011 Feb; 14(2):147-53. Carr MF, Jadhav SP, Frank LM. PMID: 21270783.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansCells
    53. Probability of repeating patterns in simultaneous neural data. Neural Comput. 2010 Oct; 22(10):2522-36. Smith AC, Nguyen VK, Karlsson MP, Frank LM, Smith P. PMID: 20608872.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    54. Experience-dependent development of coordinated hippocampal spatial activity representing the similarity of related locations. J Neurosci. 2010 Sep 01; 30(35):11586-604. Singer AC, Karlsson MP, Nathe AR, Carr MF, Frank LM. PMID: 20810880.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    55. Rewarded outcomes enhance reactivation of experience in the hippocampus. Neuron. 2009 Dec 24; 64(6):910-21. Singer AC, Frank LM. PMID: 20064396.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    56. Reactivating memories for consolidation. Neuron. 2009 Jun 25; 62(6):745-6. Jadhav SP, Frank LM. PMID: 19555641.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    57. Awake replay of remote experiences in the hippocampus. Nat Neurosci. 2009 Jul; 12(7):913-8. Karlsson MP, Frank LM. PMID: 19525943.
      View in: PubMed   Mentions: 206     Fields:    Translation:AnimalsCells
    58. Hippocampal lesions impair rapid learning of a continuous spatial alternation task. PLoS One. 2009; 4(5):e5494. Kim SM, Frank LM. PMID: 19424438.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    59. Network dynamics underlying the formation of sparse, informative representations in the hippocampus. J Neurosci. 2008 Dec 24; 28(52):14271-81. Karlsson MP, Frank LM. PMID: 19109508.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    60. Place Cells in Perspective SheriMizumoriHippocampal Place Fields: Relevance to Learning and Memory2008Oxford University Press432 pp., $98.50, hardcover. Neuron. 2008 Oct 1; 60(1):17-18. Loren Frank. .
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    61. New experiences enhance coordinated neural activity in the hippocampus. Neuron. 2008 Jan 24; 57(2):303-13. Cheng S, Frank LM. PMID: 18215626.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    62. 69: The role of primary human herpesvirus 6, 7 (HHV-6, HHV-7) infection in febrile status epilepticus. Journal of Clinical Virology. 2006 Dec 1; 37:s116. L. Epstein, D.R. Nordli, A. Hamidullah, J.M. Pellock, L.M. Frank, D.V. Lewis, D.C. Hesdorffer, A. Marmarou, C. O'Dell, S. Shinnar. .
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    63. Hippocampal and cortical place cell plasticity: implications for episodic memory. Hippocampus. 2006; 16(9):775-84. Frank LM, Brown EN, Stanley GB. PMID: 16921502.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory. J Neurosci. 2005 Jun 15; 25(24):5720-9. Law JR, Flanery MA, Wirth S, Yanike M, Smith AC, Frank LM, Suzuki WA, Brown EN, Stark CE. PMID: 15958738.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    65. An analysis of hippocampal spatio-temporal representations using a Bayesian algorithm for neural spike train decoding. IEEE Trans Neural Syst Rehabil Eng. 2005 Jun; 13(2):131-6. Barbieri R, Wilson MA, Frank LM, Brown EN. PMID: 16003890.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    66. Hippocampal plasticity across multiple days of exposure to novel environments. J Neurosci. 2004 Sep 01; 24(35):7681-9. Frank LM, Stanley GB, Brown EN. PMID: 15342735.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    67. Dynamic analysis of neural encoding by point process adaptive filtering. Neural Comput. 2004 May; 16(5):971-98. Eden UT, Frank LM, Barbieri R, Solo V, Brown EN. PMID: 15070506.
      View in: PubMed   Mentions: 81     Fields:    
    68. Dynamic analyses of information encoding in neural ensembles. Neural Comput. 2004 Feb; 16(2):277-307. Barbieri R, Frank LM, Nguyen DP, Quirk MC, Solo V, Wilson MA, Brown EN. PMID: 15006097.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    69. Dynamic analysis of learning in behavioral experiments. J Neurosci. 2004 Jan 14; 24(2):447-61. Smith AC, Frank LM, Wirth S, Yanike M, Hu D, Kubota Y, Graybiel AM, Suzuki WA, Brown EN. PMID: 14724243.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    70. A Bayesian decoding algorithm for analysis of information encoding in neural ensembles. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:4483-6. Barbieri R, Frank LM, Nguyen DP, Quirk MC, Solo V, Wilson MA, Brown EN. PMID: 17271302.
      View in: PubMed   Mentions: 2     Fields:    
    71. Making space for rats: from synapse to place code. Neuron. 2003 Aug 28; 39(5):730-1. Nathe AR, Frank LM. PMID: 12948439.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    72. Persistent activity and memory in the entorhinal cortex. Trends Neurosci. 2003 Aug; 26(8):400-1. Frank LM, Brown EN. PMID: 12900167.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    73. Single neurons in the monkey hippocampus and learning of new associations. Science. 2003 Jun 06; 300(5625):1578-81. Wirth S, Yanike M, Frank LM, Smith AC, Brown EN, Suzuki WA. PMID: 12791995.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    74. An application of reversible-jump Markov chain Monte Carlo to spike classification of multi-unit extracellular recordings. Network. 2003 Feb; 14(1):61-82. Nguyen DP, Frank LM, Brown EN. PMID: 12617059.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    75. Construction and analysis of non-Gaussian spatial models of neural spiking activity. Neurocomputing. 2002 Jun 1; 44:309-314. Riccardo Barbieri, Loren M. Frank, Michael C. Quirk, Victor Solo, Matthew A. Wilson, Emery N. Brown. .
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    76. Contrasting patterns of receptive field plasticity in the hippocampus and the entorhinal cortex: an adaptive filtering approach. J Neurosci. 2002 May 01; 22(9):3817-30. Frank LM, Eden UT, Solo V, Wilson MA, Brown EN. PMID: 11978857.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    77. The time-rescaling theorem and its application to neural spike train data analysis. Neural Comput. 2002 Feb; 14(2):325-46. Brown EN, Barbieri R, Ventura V, Kass RE, Frank LM. PMID: 11802915.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    78. Entorhinal Place Cells: Trajectory Encoding. The Neural Basis of Navigation. 2002 Jan 1; 97-116. Loren M. Frank, Emery N. Brown, Matthew A. Wilson. .
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    79. An analysis of neural receptive field plasticity by point process adaptive filtering. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12261-6. Brown EN, Nguyen DP, Frank LM, Wilson MA, Solo V. PMID: 11593043.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    80. A comparison of the firing properties of putative excitatory and inhibitory neurons from CA1 and the entorhinal cortex. J Neurophysiol. 2001 Oct; 86(4):2029-40. Frank LM, Brown EN, Wilson MA. PMID: 11600659.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    81. Diagnostic methods for statistical models of place cell spiking activity. Neurocomputing. 2001 Jun 1; 38:1087-1093. Riccardo Barbieri, Loren M. Frank, Michael C. Quirk, Matthew A. Wilson, Emery N. Brown. .
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    82. Construction and analysis of non-Poisson stimulus-response models of neural spiking activity. J Neurosci Methods. 2001 Jan 30; 105(1):25-37. Barbieri R, Quirk MC, Frank LM, Wilson MA, Brown EN. PMID: 11166363.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    83. Trajectory encoding in the hippocampus and entorhinal cortex. Neuron. 2000 Jul; 27(1):169-78. Frank LM, Brown EN, Wilson M. PMID: 10939340.
      View in: PubMed   Mentions: 169     Fields:    Translation:AnimalsCells
    84. A time-dependent analysis of spatial information encoding in the rat hippocampus. Neurocomputing. 2000 Jun 1; 32:629-635. Riccardo Barbieri, Loren M Frank, Michael C Quirk, Matthew A Wilson, Emery N Brown. .
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    85. A Statistical Paradigm for Neural Spike Train Decoding Applied to Position Prediction from Ensemble Firing Patterns of Rat Hippocampal Place Cells. Journal of Neuroscience. 1998 Sep 15; 18(18):7411-7425. Emery N. Brown, Loren M. Frank, Dengda Tang, Michael C. Quirk, Matthew A. Wilson. .
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    86. A statistical paradigm for neural spike train decoding applied to position prediction from ensemble firing patterns of rat hippocampal place cells. J Neurosci. 1998 Sep 15; 18(18):7411-25. Brown EN, Frank LM, Tang D, Quirk MC, Wilson MA. PMID: 9736661.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    87. Spin-spin relaxation of brain tissues in systemic lupus erythematosus. A method for increasing the sensitivity of magnetic resonance imaging for neuropsychiatric lupus. Arthritis Rheum. 1995 Jun; 38(6):810-8. Sibbitt WL, Brooks WM, Haseler LJ, Griffey RH, Frank LM, Hart BL, Sibbitt RR. PMID: 7779125.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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