Loading...

Zachary Knight, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentPhysiology
Address1550 Fourth St
San Francisco CA 94158
Phone415-502-2011
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    2018Investigator, Howard Hughes Medical Institute
    2016Helmholtz Young Investigator in Diabetes Award
    2016Pathway Award - American Diabetes Association
    2015NIH New Innovator Award
    2015Rita Allen Scholar Award
    2014Sloan Foundation Research Fellowship in Neuroscience
    2013Klingenstein Fellowship in Neurosciences
    2013NYSCF-Roberston Investigator Award
    2013McKnight Technological Innovations in Neuroscience Award
    2013NARSAD Young Investigator Award
    2009NIH Pathway to Independence Award
    2007Life Sciences Research Foundation Postdoctoral Fellowship
    2006UCSF Krevans Distinguished Dissertation Award
    2001Howard Hughes Medical Institute Predoctoral Fellowship
    2002Grand Prize Winner, National Collegiate Inventors Competition
    2000ARCS Foundation Predoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    We study the connection between physiology and behavior. Our goal is to understand how the brain senses the needs of the body – such as the need for food or water or warmth – and then generates specific behavioral responses that restore physiologic balance. To address this question, we use a diverse set of experimental strategies including systems neuroscience approaches such as optogenetics, electrophysiology, and calcium imaging; molecular approaches such as RNA sequencing and mouse genetics; and classical approaches such as surgical and pharmacologic manipulations. In addition, we develop new tools that enable the molecular identification of functional populations of neurons by RNA sequencing. Through the use of these approaches, we aim to identify the molecules, cell types, interconnections, and activity patterns that drive homeostatic behaviors, and further uncover how these circuit elements become
    dysregulated in conditions such as obesity.

    Our research is focused on three related topics: the control of hunger, thirst, and body temperature. A general principle emerging from our recent work has been the discovery that homeostatic circuits – long thought to function primarily by reacting to physiologic imbalances – instead utilize sensory cues to anticipate those physiologic changes and then adjust behavior preemptively. An ongoing interest of the lab is to understand how homeostatic circuits integrate sensory information from the outside world with internal signals arising from the body in order to generate and shape goal-directed behaviors.


    Collapse Research 
    Collapse Research Activities and Funding
    Warm sensitive neurons that control body temperature
    NIH/NINDS R01NS094781Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Neural Dynamics Underlying Feeding
    NIH/NIDDK R01DK106399Sep 20, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Sequencing Neural Circuits Controlling Thermoregulation
    NIH/NIDDK DP2DK109533Sep 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Mechanisms of Leptin Resistance
    NIH/NIDDK R00DK083531Sep 1, 2012 - Jul 31, 2015
    Role: Principal Investigator
    Mechanisms of Leptin Resistance
    NIH/NIDDK K99DK083531Apr 5, 2009 - Mar 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Zachary's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _