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Zachary Knight, PhD

Title(s)Associate Professor, Physiology
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-502-2011
ORCID ORCID Icon0000-0001-7621-1478 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    2019Presidential Early Career Award for Scientists and Engineers (PECASE)
    2018Investigator, Howard Hughes Medical Institute
    2016Helmholtz Young Investigator in Diabetes Award
    2016Pathway Award - American Diabetes Association
    2015NIH New Innovator Award
    2015Rita Allen Scholar Award
    2014Sloan Foundation Research Fellowship in Neuroscience
    2013Klingenstein Fellowship in Neurosciences
    2013NYSCF-Roberston Investigator Award
    2013McKnight Technological Innovations in Neuroscience Award
    2013NARSAD Young Investigator Award
    2009NIH Pathway to Independence Award
    2007Life Sciences Research Foundation Postdoctoral Fellowship
    2006UCSF Krevans Distinguished Dissertation Award
    2001Howard Hughes Medical Institute Predoctoral Fellowship
    2002Grand Prize Winner, National Collegiate Inventors Competition
    2000ARCS Foundation Predoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    We study the connection between physiology and behavior. Our goal is to understand how the brain senses the needs of the body – such as the need for food or water or warmth – and then generates specific behavioral responses that restore physiologic balance. To address this question, we use a diverse set of experimental strategies including systems neuroscience approaches such as optogenetics, electrophysiology, and calcium imaging; molecular approaches such as RNA sequencing and mouse genetics; and classical approaches such as surgical and pharmacologic manipulations. In addition, we develop new tools that enable the molecular identification of functional populations of neurons by RNA sequencing. Through the use of these approaches, we aim to identify the molecules, cell types, interconnections, and activity patterns that drive homeostatic behaviors, and further uncover how these circuit elements become
    dysregulated in conditions such as obesity.

    Our research is focused on three related topics: the control of hunger, thirst, and body temperature. A general principle emerging from our recent work has been the discovery that homeostatic circuits – long thought to function primarily by reacting to physiologic imbalances – instead utilize sensory cues to anticipate those physiologic changes and then adjust behavior preemptively. An ongoing interest of the lab is to understand how homeostatic circuits integrate sensory information from the outside world with internal signals arising from the body in order to generate and shape goal-directed behaviors.

    Collapse Research 
    Collapse Research Activities and Funding
    Neural mechanisms linking need to reward
    NIH/NINDS R01NS116626Aug 1, 2020 - Jul 31, 2025
    Role: Principal Investigator
    Warm sensitive neurons that control body temperature
    NIH/NINDS R01NS094781Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Neural Dynamics Underlying Feeding
    NIH/NIDDK R01DK106399Sep 20, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Sequencing Neural Circuits Controlling Thermoregulation
    NIH/NIDDK DP2DK109533Sep 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Mechanisms of Leptin Resistance
    NIH/NIDDK R00DK083531Sep 1, 2012 - Jul 31, 2015
    Role: Principal Investigator
    Mechanisms of Leptin Resistance
    NIH/NIDDK K99DK083531Apr 5, 2009 - Mar 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its effect on gametogenesis and early pregnancy. Am J Reprod Immunol. 2020 11; 84(5):e13351. Singh B, Gornet M, Sims H, Kisanga E, Knight Z, Segars J. PMID: 32969123.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    2. Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat. Elife. 2020 07 28; 9. Beutler LR, Corpuz TV, Ahn JS, Kosar S, Song W, Chen Y, Knight ZA. PMID: 32720646.
      View in: PubMed   Mentions:    Fields:    
    3. Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering. Neuron. 2020 08 05; 107(3):454-469.e6. Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL. PMID: 32574560.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Layers of signals that regulate appetite. Curr Opin Neurobiol. 2020 Oct; 64:79-88. Zimmerman CA, Knight ZA. PMID: 32311645.
      View in: PubMed   Mentions:    Fields:    
    5. Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known? Fertil Steril. 2020 06; 113(6):1140-1149. Segars J, Katler Q, McQueen DB, Kotlyar A, Glenn T, Knight Z, Feinberg EC, Taylor HS, Toner JP, Kawwass JF. PMID: 32482250.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsPHPublic Health
    6. Genetic Identification of Vagal Sensory Neurons That Control Feeding. Cell. 2019 11 14; 179(5):1129-1143.e23. Bai L, Mesgarzadeh S, Ramesh KS, Huey EL, Liu Y, Gray LA, Aitken TJ, Chen Y, Beutler LR, Ahn JS, Madisen L, Zeng H, Krasnow MA, Knight ZA. PMID: 31730854.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    7. Sustained NPY signaling enables AgRP neurons to drive feeding. Elife. 2019 04 29; 8. Chen Y, Essner RA, Kosar S, Miller OH, Lin YC, Mesgarzadeh S, Knight ZA. PMID: 31033437.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. A gut-to-brain signal of fluid osmolarity controls thirst satiation. Nature. 2019 04; 568(7750):98-102. Zimmerman CA, Huey EL, Ahn JS, Beutler LR, Tan CL, Kosar S, Bai L, Chen Y, Corpuz TV, Madisen L, Zeng H, Knight ZA. PMID: 30918408.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    9. Regulation of Body Temperature by the Nervous System. Neuron. 2018 04 04; 98(1):31-48. Tan CL, Knight ZA. PMID: 29621489.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    10. A Spotlight on Appetite. Neuron. 2018 02 21; 97(4):739-741. Beutler LR, Knight ZA. PMID: 29470967.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement. Neuron. 2017 12 20; 96(6):1272-1281.e4. Leib DE, Zimmerman CA, Poormoghaddam A, Huey EL, Ahn JS, Lin YC, Tan CL, Chen Y, Knight ZA. PMID: 29268095.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Linking smell to metabolism and aging. Science. 2017 11 10; 358(6364):718-719. Garrison JL, Knight ZA. PMID: 29123049.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Dynamics of Gut-Brain Communication Underlying Hunger. Neuron. 2017 Oct 11; 96(2):461-475.e5. Beutler LR, Chen Y, Ahn JS, Lin YC, Essner RA, Knight ZA. PMID: 29024666.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    14. Neural circuits underlying thirst and fluid homeostasis. Nat Rev Neurosci. 2017 08; 18(8):459-469. Zimmerman CA, Leib DE, Knight ZA. PMID: 28638120.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    15. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2017 06 01; 127(6):2438. Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. PMID: 28569734.
      View in: PubMed   Mentions: 1     Fields:    
    16. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. 2017 05 25; 545(7655):477-481. Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y. PMID: 28514446.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    17. Thirst. Curr Biol. 2016 12 19; 26(24):R1260-R1265. Leib DE, Zimmerman CA, Knight ZA. PMID: 27997832.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    18. Warm-Sensitive Neurons that Control Body Temperature. Cell. 2016 Sep 22; 167(1):47-59.e15. Tan CL, Cooke EK, Leib DE, Lin YC, Daly GE, Zimmerman CA, Knight ZA. PMID: 27616062.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    19. Hunger neurons drive feeding through a sustained, positive reinforcement signal. Elife. 2016 08 24; 5. Chen Y, Lin YC, Zimmerman CA, Essner RA, Knight ZA. PMID: 27554486.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    20. Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Rep. 2016 08 23; 16(8):2051-2052. Leib DE, Knight ZA. PMID: 27558825.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature. 2016 09 29; 537(7622):680-684. Zimmerman CA, Lin YC, Leib DE, Guo L, Huey EL, Daly GE, Chen Y, Knight ZA. PMID: 27487211.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    22. Making sense of the sensory regulation of hunger neurons. Bioessays. 2016 Apr; 38(4):316-24. Chen Y, Knight ZA. PMID: 26898524.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    23. Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism. Cell Rep. 2015 Nov 10; 13(6):1081-1089. Leib DE, Knight ZA. PMID: 26526991.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    24. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Front Oncol. 2015; 5:111. Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. PMID: 26029667.
      View in: PubMed   Mentions:
    25. Sensory detection of food rapidly modulates arcuate feeding circuits. Cell. 2015 Feb 26; 160(5):829-841. Chen Y, Lin YC, Kuo TW, Knight ZA. PMID: 25703096.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    26. A critical role for mTORC1 in erythropoiesis and anemia. Elife. 2014 Sep 08; 3:e01913. Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. PMID: 25201874.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. Ablation of AgRP neurons impairs adaption to restricted feeding. Mol Metab. 2014 Oct; 3(7):694-704. Tan K, Knight ZA, Friedman JM. PMID: 25352998.
      View in: PubMed   Mentions: 21     Fields:    
    28. Molecular profiling of neurons based on connectivity. Cell. 2014 May 22; 157(5):1230-42. Ekstrand MI, Nectow AR, Knight ZA, Latcha KN, Pomeranz LE, Friedman JM. PMID: 24855954.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    29. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 2012 Nov 21; 151(5):1126-37. Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM. PMID: 23178128.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    30. For a PDK1 inhibitor, the substrate matters. Biochem J. 2011 Jan 15; 433(2):e1-2. Knight ZA. PMID: 21175429.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. Hyperleptinemia is required for the development of leptin resistance. PLoS One. 2010 Jun 29; 5(6):e11376. Knight ZA, Hannan KS, Greenberg ML, Friedman JM. PMID: 20613882.
      View in: PubMed   Mentions: 78     Fields:    Translation:Animals
    32. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chem Biol. 2010 Feb 26; 17(2):123-34. Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM. PMID: 20189103.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    33. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer. 2010 02; 10(2):130-7. Knight ZA, Lin H, Shokat KM. PMID: 20094047.
      View in: PubMed   Mentions: 216     Fields:    Translation:Humans
    34. Small molecule inhibitors of the PI3-kinase family. Curr Top Microbiol Immunol. 2010; 347:263-78. Knight ZA. PMID: 20473788.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    35. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28; 113(22):5549-57. Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. PMID: 19318683.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    36. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10; 7(2):e38. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. PMID: 19209957.
      View in: PubMed   Mentions: 485     Fields:    Translation:AnimalsCells
    37. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. PMID: 19176518.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    38. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. PMID: 19147570.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    39. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Res. 2008 Oct 15; 68(20):8361-8. Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S. PMID: 18922908.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    40. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov; 4(11):691-9. Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. PMID: 18849971.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    41. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol. 2008 Oct; 122(4):811-819.e2. Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ. PMID: 19014771.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    42. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. 2008 Oct 01; 68(19):8127-36. Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PMID: 18829572.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    43. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J. 2008 Oct 01; 415(1):97-110. Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D. PMID: 18498248.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    44. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2008 Sep; 118(9):3038-50. Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. PMID: 18704194.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    45. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell. 2008 Aug 12; 14(2):180-92. Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM. PMID: 18691552.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    46. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50. Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. PMID: 18653476.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    47. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia. 2008 Sep; 22(9):1698-706. Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat KM, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PMID: 18548104.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    48. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7797-802. Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M. PMID: 18509048.
      View in: PubMed   Mentions: 359     Fields:    Translation:AnimalsCells
    49. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. . 2008 Apr; 7(4):841-50. Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D. PMID: 18413797.
      View in: PubMed   Mentions:
    50. Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry. 2008 Feb 12; 47(6):1599-607. Balla A, Tuymetova G, Toth B, Szentpetery Z, Zhao X, Knight ZA, Shokat K, Steinbach PJ, Balla T. PMID: 18205404.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    51. Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell. 2008 Feb; 19(2):711-21. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. PMID: 18077555.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    52. Importance of PI3 Kinase Family for Crosstalk between Chronic Lymphocytic Leukemia B Cells and the Stromal Microenvironment: Therapeutic Implications. Blood. 2007 Nov 16; 110(11):1125-1125. Matthias T.W. Niedermeier, Justyna Rawluk, Zachary Knight, Kevan Shokat, William G. Wierda, Michael J. Keating, Jan A. Burger. .
      View in: Publisher Site   Mentions:
    53. PI-103, a Dual Inhibitor of Class I Phosphatidylinositide 3-Kinase and mTOR, Has Anti-Leukemic Activity in Acute Myeloid Leukemia. Blood. 2007 Nov 16; 110(11):876-876. Sophie Park, Nicolas Chapuis, Valerie Bardet, Lise Willems, Jerome Tamburini, Zachary A. Knight, Kevan M. Shokat, Nabih Azar, Norbert Ifrah, Francois Dreyfus, Patrick Mayeux, Catherine Lacombe, Didier Bouscary. .
      View in: Publisher Site   Mentions:
    54. A remodelled protease that cleaves phosphotyrosine substrates. J Am Chem Soc. 2007 Sep 26; 129(38):11672-3. Knight ZA, Garrison JL, Chan K, King DS, Shokat KM. PMID: 17803306.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    55. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007 Sep 01; 67(17):7960-5. Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. PMID: 17804702.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    56. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. . 2007 Apr 19; 1(2):121-33. Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G. PMID: 18005690.
      View in: PubMed   Mentions:
    57. Chemically targeting the PI3K family. Biochem Soc Trans. 2007 Apr; 35(Pt 2):245-9. Knight ZA, Shokat KM. PMID: 17371250.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    58. Chemical genetics: where genetics and pharmacology meet. Cell. 2007 Feb 09; 128(3):425-30. Knight ZA, Shokat KM. PMID: 17289560.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    59. A membrane capture assay for lipid kinase activity. Nat Protoc. 2007; 2(10):2459-66. Knight ZA, Feldman ME, Balla A, Balla T, Shokat KM. PMID: 17947987.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    60. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem. 2006 Nov 24; 281(47):36369-77. Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T. PMID: 17003043.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    61. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol. 2006 Jul 31; 174(3):437-45. Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR. PMID: 16864657.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    62. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. PMID: 16697955.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    63. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19; 125(4):733-47. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. PMID: 16647110.
      View in: PubMed   Mentions: 400     Fields:    Translation:HumansAnimalsCells
    64. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. . 2006 Apr; 5(4):885-92. Sturgeon CM, Knight ZA, Shokat KM, Roberge M. PMID: 16648558.
      View in: PubMed   Mentions:
    65. Knock-outs and inhibitors: one and the same?. Blood. 2006 Jan 15; 107(2):420-421. Zachary A. Knight, Kevan M. Shokat. .
      View in: Publisher Site   Mentions:
    66. Features of selective kinase inhibitors. Chem Biol. 2005 Jun; 12(6):621-37. Knight ZA, Shokat KM. PMID: 15975507.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimals
    67. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorg Med Chem. 2005 Apr 15; 13(8):2825-36. Alaimo PJ, Knight ZA, Shokat KM. PMID: 15781393.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    68. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 01; 12(17):4749-59. Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. PMID: 15358300.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    69. Erratum: Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nature Biotechnology. 2003 Nov 1; 21(11):1396-1396. Zachary A Knight, Birgit Schilling, Richard H Row, Denise M Kenski, Bradford W Gibson, Kevan M Shokat. .
      View in: Publisher Site   Mentions:
    70. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nat Biotechnol. 2003 Sep; 21(9):1047-54. Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat KM. PMID: 12923550.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    71. A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev. 2003 Jul 15; 17(14):1779-88. Tzfati Y, Knight Z, Roy J, Blackburn EH. PMID: 12832393.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    72. Another possible mechanism of resistance to STI571. Blood. 2000 Dec 01; 96(12):4003-5. Knight ZA. PMID: 11186275.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    73. Another possible mechanism of resistance to STI571. Blood. 2000 Dec 1; 96(12):4003-4005. Zachary A. Knight. .
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