Juha Klefstrom, MSc, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSW, #760
San Francisco CA 94143
ORCID ORCID Icon0000-0001-7124-8431 Additional info
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    Juha Klefstrom is Adjunct Professor in the Department of Cell and Tissue Biology, UCSF. He is also a Research Professor at the Finnish Cancer Institute and affiliated with the Helsinki University Hospital and Medical Faculty, University of Helsinki.

    Klefstrom laboratory strives to advance basic cancer research toward early clinical development, focusing on therapeutic strategies that exploit oncogene-induced vulnerabilities in cancer. Our research focuses on therapeutically intervenable metabolic vulnerabilities caused by the oncogenic MYC protein, synthetic lethal approaches to treat breast cancer and, several strategies to enhance immunotherapies through immunogenic cell death. Moreover, Klefstrom Lab develops and tests chemical compounds to explore synthetic lethal therapeutic opportunities and novel biological mechanisms. Klefstrom Lab has established three-dimensional culture systems and patient tumor-derived breast explant cultures for ex vivo target validation, drug testing and for studies of breast cancer development. Klefstrom has special expertise in breast cancer biology, translational oncology, cancer metabolism, oncogenes, synthetic lethal strategies, combination immune therapies, preclinical genetically engineered mouse models, ex vivo organoid cultures and recombinant viral gene/shRNA/CRISPR gRNA transfer methods.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses. Oncoimmunology. 2025 Dec; 14(1):2466305. Turpin R, Peltonen K, Rannikko JH, Liu R, Kumari AN, Nicorici D, Lee MH, Mutka M, Kovanen PE, Niinikoski L, Meretoja T, Mattson J, Järvinen P, Lahdensuo K, Järvinen R, Tornberg S, Mirtti T, Boström P, Koskivuo I, Thotakura A, Pouwels J, Hollmén M, Mustjoki S, Klefström J. PMID: 39960413; PMCID: PMC11834457.
      View in: PubMed   Mentions:    Fields:    
    2. Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment. J Immunother Cancer. 2024 Apr 11; 12(4). Turpin R, Liu R, Munne PM, Peura A, Rannikko JH, Philips G, Boeckx B, Salmelin N, Hurskainen E, Suleymanova I, Aung J, Vuorinen EM, Lehtinen L, Mutka M, Kovanen PE, Niinikoski L, Meretoja TJ, Mattson J, Mustjoki S, Saavalainen P, Goga A, Lambrechts D, Pouwels J, Hollmén M, Klefström J. PMID: 38604809; PMCID: PMC11015234.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Liprin-a1 contributes to oncogenic MAPK signaling by counteracting ERK activity. Mol Oncol. 2024 Mar; 18(3):662-676. Pehkonen H, Filippou A, Väänänen J, Lindfors I, Vänttinen M, Ianevski P, Mäkelä A, Munne P, Klefström J, Toppila-Salmi S, Grénman R, Hagström J, Mäkitie AA, Karhemo PR, Monni O. PMID: 38264964; PMCID: PMC10920090.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Hepsin promotes breast tumor growth signaling via the TGFß-EGFR axis. Mol Oncol. 2024 Mar; 18(3):547-561. Belitškin D, Munne P, Pant SM, Anttila JM, Suleymanova I, Belitškina K, Kirchhofer D, Janetka J, Käsper T, Jalil S, Pouwels J, Tervonen TA, Klefström J. PMID: 37872868; PMCID: PMC10920082.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization. Sci Rep. 2023 Oct 11; 13(1):17162. Tanjore Ramanathan J, Zárybnický T, Filppu P, Monzo HJ, Monni O, Tervonen TA, Klefström J, Kerosuo L, Kuure S, Laakkonen P. PMID: 37821496; PMCID: PMC10567708.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells. Adv Healthc Mater. 2023 Dec; 12(31):e2301137. Heilala M, Lehtonen A, Arasalo O, Peura A, Pokki J, Ikkala O, Klefström J, Munne PM. PMID: 37671812; PMCID: PMC11469292.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. MYC-an emerging player in mitochondrial diseases. Front Cell Dev Biol. 2023; 11:1257651. Purhonen J, Klefström J, Kallijärvi J. PMID: 37731815; PMCID: PMC10507175.
      View in: PubMed   Mentions: 4  
    8. Laminin matrix adhesion regulates basal mammary epithelial cell identity. J Cell Sci. 2022 Dec 01; 135(23). Englund JI, Bui H, Dinç DD, Paavolainen O, McKenna T, Laitinen S, Munne P, Klefström J, Peuhu E, Katajisto P. PMID: 36468336.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer. Nat Commun. 2022 Nov 21; 13(1):7140. Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A. PMID: 36414627; PMCID: PMC9681724.
      View in: PubMed   Mentions:    Fields:    
    10. Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer. Nat Commun. 2022 06 27; 13(1):3671. Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A. PMID: 35760778; PMCID: PMC9237085.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    11. Compressive stress-mediated p38 activation required for ERa?+?phenotype in breast cancer. Nat Commun. 2021 Nov 29; 12(1):6967. Munne PM, Martikainen L, Räty I, Bertula K, Ruuska J, Ala-Hongisto H, Peura A, Hollmann B, Euro L, Yavuz K, Patrikainen L, Salmela M, Pokki J, Kivento M, Väänänen J, Suomi T, Nevalaita L, Mutka M, Kovanen P, Leidenius M, Meretoja T, Hukkinen K, Monni O, Pouwels J, Sahu B, Mattson J, Joensuu H, Heikkilä P, Elo LL, Metcalfe C, Junttila MR, Ikkala O, Klefström J. PMID: 34845227; PMCID: PMC8630031.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    12. Sortilin-related receptor is a druggable therapeutic target in breast cancer. Mol Oncol. 2022 Jan; 16(1):116-129. Al-Akhrass H, Pietilä M, Lilja J, Vesilahti EM, Anttila JM, Haikala HM, Munne PM, Klefström J, Peuhu E, Ivaska J, Al-Akhrass H, Pietilä M, Lilja J, Vesilahti EM, Anttila JM, Haikala HM, Munne PM, Klefström J, Peuhu E, Ivaska J. PMID: 34564954; PMCID: PMC8732349.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Hepsin regulates TGFß signaling via fibronectin proteolysis. EMBO Rep. 2021 Nov 04; 22(11):e52532. Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Hongisto HA, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J, Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Hongisto HA, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J. PMID: 34515392; PMCID: PMC8567232.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2021 Mar 09; 13(5). Filippou A, Pehkonen H, Karhemo PR, Väänänen J, Nieminen AI, Klefström J, Grénman R, Mäkitie AA, Joensuu H, Monni O. PMID: 33803266; PMCID: PMC7967175.
      View in: PubMed   Mentions: 7  
    15. Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin. Cancer Res. 2021 Mar 15; 81(6):1513-1527. Tervonen TA, Pant SM, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. PMID: 33461973.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis. Sci Rep. 2020 Oct 30; 10(1):18733. Utz B, Turpin R, Lampe J, Pouwels J, Klefström J. PMID: 33127915; PMCID: PMC7599250.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis. Cancer Res. 2020 Apr 01; 80(7):1414-1427. Qiao X, Liu Y, Prada ML, Mohan AK, Gupta A, Jaiswal A, Sharma M, Merisaari J, Haikala HM, Talvinen K, Yetukuri L, Pylvänäinen JW, Klefström J, Kronqvist P, Meinander A, Aittokallio T, Hietakangas V, Eilers M, Westermarck J, Qiao X, Liu Y, Prada ML, Mohan AK, Gupta A, Jaiswal A, Sharma M, Merisaari J, Haikala HM, Talvinen K, Yetukuri L, Pylvänäinen JW, Klefström J, Kronqvist P, Meinander A, Aittokallio T, Hietakangas V, Eilers M, Westermarck J. PMID: 32029551.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    18. Strain-Stiffening of Agarose Gels. ACS Macro Lett. 2019 Jun 18; 8(6):670-675. Bertula K, Martikainen L, Munne P, Hietala S, Klefström J, Ikkala O. PMID: 35619522.
      View in: PubMed   Mentions: 26     Fields:    
    19. Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019 Feb 20; 10(1):932. Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J. PMID: 30787321; PMCID: PMC6382943.
      View in: PubMed   Mentions: 1     Fields:    
    20. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019 Feb 06; 10(1):620. Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J. PMID: 30728358; PMCID: PMC6365524.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    21. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. J Med Chem. 2019 01 24; 62(2):480-490. Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant SM, Helander J, Klefström J, Craik CS, Janetka JW. PMID: 30571119.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. J Med Chem. 2018 May 24; 61(10):4335-4347. Pant SM, Mukonoweshuro A, Desai B, Ramjee MK, Selway CN, Tarver GJ, Wright AG, Birchall K, Chapman TM, Tervonen TA, Klefström J. PMID: 29701962.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Phenotype-driven identification of epithelial signalling clusters. Sci Rep. 2018 Mar 05; 8(1):4034. Marques E, Peltola T, Kaski S, Klefström J. PMID: 29507319; PMCID: PMC5838230.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture. Methods Mol Biol. 2018; 1731:169-178. Pant SM, Belitskin D, Ala-Hongisto H, Klefström J, Tervonen TA. PMID: 29318553.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Virtual Screening of Transmembrane Serine Protease Inhibitors. Bio Protoc. 2017 Apr 20; 7(8):e2246. Poso A, Tervonen T, Klefström J. PMID: 34541238; PMCID: PMC8410343.
      View in: PubMed   Mentions:
    26. MYC and AMPK-Save Energy or Die! Front Cell Dev Biol. 2017; 5:38. Haikala HM, Anttila JM, Klefström J. PMID: 28443281; PMCID: PMC5386972.
      View in: PubMed   Mentions: 16  
    27. Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases. 2018 May 04; 9(3):274-282. Haikala HM, Marques E, Turunen M, Klefström J. PMID: 27532209; PMCID: PMC5927483.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Data integration to prioritize drugs using genomics and curated data. BioData Min. 2016; 9:21. Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S. PMID: 27231484; PMCID: PMC4881054.
      View in: PubMed   Mentions: 6  
    29. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell Cycle. 2016; 15(3):316-23. Haikala HM, Klefström J, Eilers M, Wiese KE. PMID: 26873145; PMCID: PMC4943699.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    30. Par6 family proteins in cancer. Oncoscience. 2015; 2(11):894-5. Marques E, Klefström J. PMID: 26697513; PMCID: PMC4675776.
      View in: PubMed   Mentions: 7  
    31. Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell Rep. 2015 Aug 11; 12(6):1019-31. Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J. PMID: 26235622; PMCID: PMC4535171.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    32. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene. 2016 Apr 07; 35(14):1832-46. Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J. PMID: 26165838.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene. 2016 Mar 17; 35(11):1386-98. Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J. PMID: 26073086; PMCID: PMC4800288.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J. 2015 Jun 03; 34(11):1554-71. Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M. PMID: 25896507; PMCID: PMC4474530.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    35. Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2. Cancer Discov. 2015 May; 5(5):506-19. Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H. PMID: 25716347.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    36. Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells. Cancer Res. 2013 Nov 15; 73(22):6757-69. Khanna A, Kauko O, Böckelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T, Westermarck J. PMID: 24072747; PMCID: PMC3870284.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    37. Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130111. Partanen JI, Tervonen TA, Klefström J. PMID: 24062587; PMCID: PMC3785967.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    38. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):E1839-48. Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J. PMID: 23589839; PMCID: PMC3657814.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    39. Impact of epithelial organization on Myc expression and activity--letter. Cancer Res. 2012 Feb 15; 72(4):1035; author reply 1036. Partanen JI, Klefstrom J. PMID: 22277913.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    40. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E388-97. Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. PMID: 22308451; PMCID: PMC3289385.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    41. Faulty epithelial polarity genes and cancer. Adv Cancer Res. 2011; 111:97-161. Tervonen TA, Partanen JI, Saarikoski ST, Myllynen M, Marques E, Paasonen K, Moilanen A, Wohlfahrt G, Kovanen PE, Klefstrom J. PMID: 21704831.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    42. Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L). Mol Cell Endocrinol. 2010 Dec 15; 330(1-2):17-24. Jääskeläinen M, Nieminen A, Pökkylä RM, Kauppinen M, Liakka A, Heikinheimo M, Vaskivuo TE, Klefström J, Tapanainen JS. PMID: 20673843.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    43. GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocr Relat Cancer. 2010 Sep; 17(3):709-17. Kyrönlahti A, Kauppinen M, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M. PMID: 20554787.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. Int J Cancer. 2009 Nov 15; 125(10):2441-9. Rajecki M, af Hällström T, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen AI, Tenhunen M, Rantanen V, Desmond RA, Chen DT, Guse K, Stenman UH, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Ahtiainen L, Hemminki A. PMID: 19672857.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    45. 3D view to tumor suppression: Lkb1, polarity and the arrest of oncogenic c-Myc. Cell Cycle. 2009 Mar 01; 8(5):716-24. Partanen JI, Nieminen AI, Klefstrom J. PMID: 19221484.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    46. Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC Genomics. 2008 Jul 24; 9:348. Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefström J, Hautaniemi S, Monni O. PMID: 18652687; PMCID: PMC2496917.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    47. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14694-9. Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J. PMID: 17766436; PMCID: PMC1976192.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    48. c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell Cycle. 2007 Oct 15; 6(20):2464-72. Nieminen AI, Partanen JI, Klefstrom J. PMID: 17914284.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    49. c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J. 2007 Feb 21; 26(4):1055-67. Nieminen AI, Partanen JI, Hau A, Klefstrom J. PMID: 17268552; PMCID: PMC1852827.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    50. [Lentiviruses to use]. Duodecim. 2003; 119(20):1917-9. Klefström J, Alitalo K. PMID: 14639995.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    51. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell. 2002 Sep; 2(3):229-41. Verschuren EW, Klefstrom J, Evan GI, Jones N. PMID: 12242155.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    52. c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. J Biol Chem. 2002 Nov 08; 277(45):43224-32. Klefstrom J, Verschuren EW, Evan G. PMID: 12202489.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    53. c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors. Oncogene. 1999 Apr 01; 18(13):2181-8. Klefstrom J, Kovanen PE, Somersalo K, Hueber AO, Littlewood T, Evan GI, Greenberg AH, Saksela E, Timonen T, Alitalo K. PMID: 10327064.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro. Cancer Lett. 1998 Mar 13; 125(1-2):191-8. Kinnula VL, Aito H, Klefstrom J, Alitalo K, Raivio KO. PMID: 9566715.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    55. Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation. EMBO J. 1997 Dec 15; 16(24):7382-92. Klefstrom J, Arighi E, Littlewood T, Jäättelä M, Saksela E, Evan GI, Alitalo K. PMID: 9405367; PMCID: PMC1170338.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    56. BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood. 1997 Aug 01; 90(3):1168-74. Monni O, Joensuu H, Franssila K, Klefstrom J, Alitalo K, Knuutila S. PMID: 9242549.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    57. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene. 1997 May 22; 14(20):2475-83. Enholm B, Paavonen K, Ristimäki A, Kumar V, Gunji Y, Klefstrom J, Kivinen L, Laiho M, Olofsson B, Joukov V, Eriksson U, Alitalo K. PMID: 9188862.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    58. c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. EMBO J. 1994 Nov 15; 13(22):5442-50. Klefstrom J, Västrik I, Saksela E, Valle J, Eilers M, Alitalo K. PMID: 7957110; PMCID: PMC395501.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    59. Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin's lymphomas. Leuk Res. 1994 Apr; 18(4):245-50. Klefstrom J, Franssila K, Peltomäki P, Kaartinen M, Solin ML, Knuutila S. PMID: 8170168.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    60. Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation. Eur J Haematol. 1994 Feb; 52(2):65-72. Knuutila S, Klefström J, Szymanska J, Lakkala T, Peltomäki P, Eray M, Teerenhovi L, Elonen E, Franssila KO, Kaartinen M. PMID: 8119385.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    61. Myc protein: partners and antagonists. Crit Rev Oncog. 1994; 5(1):59-68. Västrik I, Mäkelä TP, Koskinen PJ, Klefstrom J, Alitalo K. PMID: 7948108.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    62. A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses. Int J Cancer. 1993 Oct 21; 55(4):655-9. Klefstrom J, Koskinen PJ, Saksela E, Jäättelä M, Bravo R, Alitalo K. PMID: 8406996.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    63. [Complex mechanics of tumor-necrosis-factor-induced cell death]. Duodecim. 1992; 108(17):1449-55. Klefström J, Saksela E, Alitalo K. PMID: 1366165.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    64. [The use of polymerase chain reaction in the diagnosis of non-Hodgkin's lymphoma]. Duodecim. 1990; 106(23-24):1645-53. Klefström J, Kaartinen M, Peltomäki P, Solin ML, Franssila K, Knuutila S. PMID: 1364696.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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