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Mehrdad Matloubian, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-476-0738
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies Graduate Division

    Collapse Overview 
    Collapse Overview
    I have a general interest in mechanisms of immune mediated diseases and approaches for a better understanding of the molecular bases of such processes. The goal is to provided therapeutic for treatment of autoimmune and inflammatory diseases through a better understanding of the involved pathways.

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Lymphocyte Trafficking by S1P1 and CD69
    NIH/NIAID R01AI074694Jul 26, 2010 - May 31, 2013
    Role: Principal Investigator
    Molecular and Cellular Regulation of Lymphocyte Exit by Interferon
    NIH/NIAID K08AI072289Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):1076-1076. Amy Jo Chien, Amelia S Gliwa, Siti Rahmaputri, Heidi F Dittrich, Melanie Catherine Majure, Hope S. Rugo, Michelle E. Melisko, Pamela N. Munster, John W. Park, Mark M. Moasser, Mehrdad Matloubian, Tasha Lea, Julia Rohrberg, Gregor Krings, Andrei Goga. .
      View in: Publisher Site   Mentions:
    2. The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training. J Grad Med Educ. 2020 Feb; 12(1):92-97. Berger A, Matloubian M, Shah NP, Wachter RM, DeRisi JL, Anderson M. PMID: 32089799.
      View in: PubMed   Mentions:    Fields:    
    3. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep. 2017 Nov 28; 21(9):2500-2514. Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA. PMID: 29186687.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation. Am J Physiol Regul Integr Comp Physiol. 2016 06 01; 310(11):R1244-57. Hasdemir B, Mhaske P, Paruthiyil S, Garnett EA, Heyman MB, Matloubian M, Bhargava A. PMID: 27053649.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    6. 522 Sex-Specific Responses of the Corticotropin-Releasing Factor System in a Mouse Model of Inflammatory Bowel Disease. Gastroenterology. 2015 Apr 1; 148(4):s-103. Burcu Hasdemir, Shilpi Mahajan, Mehrdad Matloubian, Aditi Bhargava. .
      View in: Publisher Site   Mentions:
    7. Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center. J Immunol. 2015 Apr 01; 194(7):2993-7. Mueller J, Matloubian M, Zikherman J. PMID: 25725108.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    8. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. PMID: 25136127.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    9. 91 Homotypic T–T synapses promote collective CD8+ T cell differentiation through exchange of IFN gamma. Cytokine. 2013 Sep 1; 63(3):264. Audrey Gérard, Omar Khan, Peter Beemiller, Erin Oswald, Joyce Hu, Mehrdad Matloubian, Matthew F. Krummel. .
      View in: Publisher Site   Mentions:
    10. 16 MIR-17~92 promotes T follicular helper cell differentiation and represses subset-inappropriate gene expression. Cytokine. 2013 Sep 1; 63(3):246-247. Dirk Baumjohann, Robin Kageyama, Jonathan M. Clingan, Malika M. Morar, Sana Patel, Dimitri de Kouchkovsky, Oliver Bannard, Jeffrey A. Bluestone, Mehrdad Matloubian, K Mark Ansel, Lukas T. Jeker. .
      View in: Publisher Site   Mentions:
    11. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8. Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. PMID: 23812098.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    12. B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J Immunol. 2013 Jul 15; 191(2):810-8. Clingan JM, Matloubian M. PMID: 23761632.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    13. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. PMID: 23657000.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    14. MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. PMID: 23550637.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    15. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. PMID: 23475183.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    16. Th1 cell induction in lymph nodes according to a red-blue chemokine map. Immunity. 2012 Dec 14; 37(6):954-6. Matloubian M, Cyster JG. PMID: 23244716.
      View in: PubMed   Mentions: 7     Fields:    
    17. Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection. J Immunol. 2012 May 01; 188(9):4432-40. Clingan JM, Ostrow K, Hosiawa KA, Chen ZJ, Matloubian M. PMID: 22447976.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    18. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81. Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. PMID: 21820330.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    19. Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E118-27. Hu JK, Kagari T, Clingan JM, Matloubian M. PMID: 21518913.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    20. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16234-9. Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. PMID: 20805505.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    21. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity. 2008 Jan; 28(1):122-33. Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG. PMID: 18164221.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    22. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15430-5. Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. PMID: 17878315.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    23. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007 Aug 03; 317(5838):670-4. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. PMID: 17673664.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    24. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature. 2006 Mar 23; 440(7083):540-4. Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M. PMID: 16525420.
      View in: PubMed   Mentions: 396     Fields:    Translation:HumansAnimalsCells
    25. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 09; 309(5741):1735-9. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. PMID: 16151014.
      View in: PubMed   Mentions: 294     Fields:    Translation:AnimalsCells
    26. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol. 2004 Jul; 5(7):713-20. Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG. PMID: 15184895.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    27. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22; 427(6972):355-60. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. PMID: 14737169.
      View in: PubMed   Mentions: 763     Fields:    Translation:AnimalsCells
    28. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. PMID: 12077273.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    29. Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection. J Immunol. 2001 Oct 15; 167(8):4566-73. Wu-Hsieh BA, Whitmire JK, de Fries R, Lin JS, Matloubian M, Ahmed R. PMID: 11591785.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct; 1(4):298-304. Matloubian M, David A, Engel S, Ryan JE, Cyster JG. PMID: 11017100.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    31. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol. 1999 Mar; 73(3):2527-36. Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, Walsh CM, Clark WR, Ahmed R. PMID: 9971838.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    32. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 1996 Dec 15; 157(12):5543-54. van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R. PMID: 8955205.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    33. Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes. J Virol. 1996 May; 70(5):2902-10. Slifka MK, Shen H, Matloubian M, Jensen ER, Miller JF, Ahmed R. PMID: 8627765.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    34. Mechanisms of CTL-mediated cytoxicity. Seminars in Virology. 1996 Apr 1; 7(2):113-116. William R. Clark, Craig M. Walsh, Mehrdad Matloubian, Alison A. Glass, Fumitaka Hayashi. .
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    35. Molecular pathways of CTL-mediated cytotoxicity. Immunol Rev. 1995 Aug; 146:33-44. Clark WR, Walsh CM, Glass AA, Hayashi F, Matloubian M, Ahmed R. PMID: 7493758.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    36. Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):3987-91. Shen H, Slifka MK, Matloubian M, Jensen ER, Ahmed R, Miller JF. PMID: 7732018.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    37. Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol. 1995 Mar; 69(3):1895-902. Slifka MK, Matloubian M, Ahmed R. PMID: 7853531.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    38. Cell-mediated cytotoxicity in perforin-less mice. Int Rev Immunol. 1995; 13(1):1-14. Clark WR, Walsh CM, Glass AA, Huang MT, Ahmed R, Matloubian M. PMID: 7494105.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol. 1994 Dec; 68(12):8056-63. Matloubian M, Concepcion RJ, Ahmed R. PMID: 7966595.
      View in: PubMed   Mentions: 388     Fields:    Translation:AnimalsCells
    40. Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10854-8. Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR. PMID: 7526382.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    41. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J Virol. 1993 Dec; 67(12):7340-9. Matloubian M, Kolhekar SR, Somasundaram T, Ahmed R. PMID: 7693969.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    42. Molecular basis of organ-specific selection of viral variants during chronic infection. J Virol. 1991 Aug; 65(8):4242-7. Ahmed R, Hahn CS, Somasundaram T, Villarete L, Matloubian M, Strauss JH. PMID: 2072451.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    43. Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. J Exp Med. 1990 Oct 01; 172(4):1043-8. Matloubian M, Somasundaram T, Kolhekar SR, Selvakumar R, Ahmed R. PMID: 2212940.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    44. Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus. J Virol. 1988 Sep; 62(9):3301-8. Ahmed R, Simon RS, Matloubian M, Kolhekar SR, Southern PJ, Freedman DM. PMID: 3261347.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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