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Mehrdad Matloubian, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies Graduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Lymphocyte Trafficking by S1P1 and CD69
    NIH/NIAID R01AI074694Jun 1, 2008 - May 31, 2013
    Role: Principal Investigator
    Molecular and Cellular Regulation of Lymphocyte Exit by Interferon
    NIH/NIAID K08AI072289Jun 1, 2007 - Apr 30, 2010
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA. Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep. 2017 Nov 28; 21(9):2500-2514. PMID: 29186687.
      View in: PubMed
    2. Hasdemir B, Mhaske P, Paruthiyil S, Garnett EA, Heyman MB, Matloubian M, Bhargava A. Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation. Am J Physiol Regul Integr Comp Physiol. 2016 06 01; 310(11):R1244-57. PMID: 27053649; PMCID: PMC4935495 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    3. Mueller J, Matloubian M, Zikherman J. Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center. J Immunol. 2015 Apr 01; 194(7):2993-7. PMID: 25725108; PMCID: PMC4369439.
      View in: PubMed, PubMed Central
    4. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. PMID: 25136127; PMCID: PMC4156735.
      View in: PubMed, PubMed Central
    5. Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8. PMID: 23812098; PMCID: PMC3720769.
      View in: PubMed, PubMed Central
    6. Clingan JM, Matloubian M. B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J Immunol. 2013 Jul 15; 191(2):810-8. PMID: 23761632; PMCID: PMC3702634.
      View in: PubMed, PubMed Central
    7. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. PMID: 23657000; PMCID: PMC3720065.
      View in: PubMed, PubMed Central
    8. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52. PMID: 23550637; PMCID: PMC3621029.
      View in: PubMed, PubMed Central
    9. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63. PMID: 23475183; PMCID: PMC3962671.
      View in: PubMed, PubMed Central
    10. Matloubian M, Cyster JG. Th1 cell induction in lymph nodes according to a red-blue chemokine map. Immunity. 2012 Dec 14; 37(6):954-6. PMID: 23244716; PMCID: PMC3540980.
      View in: PubMed, PubMed Central
    11. Clingan JM, Ostrow K, Hosiawa KA, Chen ZJ, Matloubian M. Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection. J Immunol. 2012 May 01; 188(9):4432-40. PMID: 22447976; PMCID: PMC3331923.
      View in: PubMed, PubMed Central
    12. Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81. PMID: 21820330; PMCID: PMC3361370.
      View in: PubMed, PubMed Central
    13. Hu JK, Kagari T, Clingan JM, Matloubian M. Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E118-27. PMID: 21518913; PMCID: PMC3102421.
      View in: PubMed, PubMed Central
    14. Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16234-9. PMID: 20805505; PMCID: PMC2941278.
      View in: PubMed, PubMed Central
    15. Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity. 2008 Jan; 28(1):122-33. PMID: 18164221; PMCID: PMC2691390.
      View in: PubMed, PubMed Central
    16. Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15430-5. PMID: 17878315; PMCID: PMC2000533.
      View in: PubMed, PubMed Central
    17. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007 Aug 03; 317(5838):670-4. PMID: 17673664.
      View in: PubMed
    18. Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature. 2006 Mar 23; 440(7083):540-4. PMID: 16525420.
      View in: PubMed
    19. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 09; 309(5741):1735-9. PMID: 16151014.
      View in: PubMed
    20. Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol. 2004 Jul; 5(7):713-20. PMID: 15184895.
      View in: PubMed
    21. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22; 427(6972):355-60. PMID: 14737169.
      View in: PubMed
    22. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. PMID: 12077273.
      View in: PubMed
    23. Wu-Hsieh BA, Whitmire JK, de Fries R, Lin JS, Matloubian M, Ahmed R. Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection. J Immunol. 2001 Oct 15; 167(8):4566-73. PMID: 11591785.
      View in: PubMed
    24. Matloubian M, David A, Engel S, Ryan JE, Cyster JG. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct; 1(4):298-304. PMID: 11017100.
      View in: PubMed
    25. Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, Walsh CM, Clark WR, Ahmed R. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol. 1999 Mar; 73(3):2527-36. PMID: 9971838; PMCID: PMC104500.
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    26. van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 1996 Dec 15; 157(12):5543-54. PMID: 8955205.
      View in: PubMed
    27. Slifka MK, Shen H, Matloubian M, Jensen ER, Miller JF, Ahmed R. Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes. J Virol. 1996 May; 70(5):2902-10. PMID: 8627765; PMCID: PMC190148.
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    28. Clark WR, Walsh CM, Glass AA, Hayashi F, Matloubian M, Ahmed R. Molecular pathways of CTL-mediated cytotoxicity. Immunol Rev. 1995 Aug; 146:33-44. PMID: 7493758.
      View in: PubMed
    29. Shen H, Slifka MK, Matloubian M, Jensen ER, Ahmed R, Miller JF. Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):3987-91. PMID: 7732018; PMCID: PMC42087.
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    30. Slifka MK, Matloubian M, Ahmed R. Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol. 1995 Mar; 69(3):1895-902. PMID: 7853531; PMCID: PMC188803.
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    31. Clark WR, Walsh CM, Glass AA, Huang MT, Ahmed R, Matloubian M. Cell-mediated cytotoxicity in perforin-less mice. Int Rev Immunol. 1995; 13(1):1-14. PMID: 7494105.
      View in: PubMed
    32. Matloubian M, Concepcion RJ, Ahmed R. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol. 1994 Dec; 68(12):8056-63. PMID: 7966595; PMCID: PMC237269.
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    33. Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR. Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10854-8. PMID: 7526382; PMCID: PMC45124.
      View in: PubMed, PubMed Central
    34. Matloubian M, Kolhekar SR, Somasundaram T, Ahmed R. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J Virol. 1993 Dec; 67(12):7340-9. PMID: 7693969; PMCID: PMC238198.
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    35. Ahmed R, Hahn CS, Somasundaram T, Villarete L, Matloubian M, Strauss JH. Molecular basis of organ-specific selection of viral variants during chronic infection. J Virol. 1991 Aug; 65(8):4242-7. PMID: 2072451; PMCID: PMC248861.
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    36. Matloubian M, Somasundaram T, Kolhekar SR, Selvakumar R, Ahmed R. Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. J Exp Med. 1990 Oct 01; 172(4):1043-8. PMID: 2212940; PMCID: PMC2188602.
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    37. Ahmed R, Simon RS, Matloubian M, Kolhekar SR, Southern PJ, Freedman DM. Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus. J Virol. 1988 Sep; 62(9):3301-8. PMID: 3261347; PMCID: PMC253451.
      View in: PubMed, PubMed Central
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