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Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2. medRxiv. 2021 Apr 09.
Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ. PMID: 33851176.
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A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. Sci Signal. 2021 02 02; 14(668).
Shen L, Matloubian M, Kadlecek TA, Weiss A. PMID: 33531381.
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A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):1076-1076.
Amy Jo Chien, Amelia S Gliwa, Siti Rahmaputri, Heidi F Dittrich, Melanie Catherine Majure, Hope S. Rugo, Michelle E. Melisko, Pamela N. Munster, John W. Park, Mark M. Moasser, Mehrdad Matloubian, Tasha Lea, Julia Rohrberg, Gregor Krings, Andrei Goga. .
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The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training. J Grad Med Educ. 2020 Feb; 12(1):92-97.
Berger A, Matloubian M, Shah NP, Wachter RM, DeRisi JL, Anderson M. PMID: 32089799.
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Humans
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miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4.
Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep. 2017 Nov 28; 21(9):2500-2514.
Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA. PMID: 29186687.
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8 Fields:
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AnimalsCells
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Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation. . 2016 06 01; 310(11):R1244-57.
Hasdemir B, Mhaske P, Paruthiyil S, Garnett EA, Heyman MB, Matloubian M, Bhargava A. PMID: 27053649.
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522 Sex-Specific Responses of the Corticotropin-Releasing Factor System in a Mouse Model of Inflammatory Bowel Disease. Gastroenterology. 2015 Apr 1; 148(4):s-103.
Burcu Hasdemir, Shilpi Mahajan, Mehrdad Matloubian, Aditi Bhargava. .
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Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center. J Immunol. 2015 Apr 01; 194(7):2993-7.
Mueller J, Matloubian M, Zikherman J. PMID: 25725108.
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25 Fields:
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AnimalsCells
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A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88.
Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. PMID: 25136127.
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PubMed Mentions:
54 Fields:
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AnimalsCells
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91 Homotypic T–T synapses promote collective CD8+ T cell differentiation through exchange of IFN gamma. Cytokine. 2013 Sep 1; 63(3):264.
Audrey Gérard, Omar Khan, Peter Beemiller, Erin Oswald, Joyce Hu, Mehrdad Matloubian, Matthew F. Krummel. .
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16 MIR-17~92 promotes T follicular helper cell differentiation and represses subset-inappropriate gene expression. Cytokine. 2013 Sep 1; 63(3):246-247.
Dirk Baumjohann, Robin Kageyama, Jonathan M. Clingan, Malika M. Morar, Sana Patel, Dimitri de Kouchkovsky, Oliver Bannard, Jeffrey A. Bluestone, Mehrdad Matloubian, K Mark Ansel, Lukas T. Jeker. .
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The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8.
Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. PMID: 23812098.
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PubMed Mentions:
95 Fields:
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AnimalsCells
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B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J Immunol. 2013 Jul 15; 191(2):810-8.
Clingan JM, Matloubian M. PMID: 23761632.
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27 Fields:
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AnimalsCells
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IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83.
Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. PMID: 23657000.
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PubMed Mentions:
30 Fields:
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AnimalsCells
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MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52.
Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. PMID: 23550637.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63.
Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. PMID: 23475183.
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56 Fields:
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AnimalsCells
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Th1 cell induction in lymph nodes according to a red-blue chemokine map. Immunity. 2012 Dec 14; 37(6):954-6.
Matloubian M, Cyster JG. PMID: 23244716.
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8 Fields:
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Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection. J Immunol. 2012 May 01; 188(9):4432-40.
Clingan JM, Ostrow K, Hosiawa KA, Chen ZJ, Matloubian M. PMID: 22447976.
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15 Fields:
Translation:
AnimalsCells
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MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81.
Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. PMID: 21820330.
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136 Fields:
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AnimalsCells
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Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E118-27.
Hu JK, Kagari T, Clingan JM, Matloubian M. PMID: 21518913.
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65 Fields:
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AnimalsCells
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Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16234-9.
Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. PMID: 20805505.
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24 Fields:
Translation:
AnimalsCells
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S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity. 2008 Jan; 28(1):122-33.
Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG. PMID: 18164221.
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PubMed Mentions:
173 Fields:
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AnimalsCells
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Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15430-5.
Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. PMID: 17878315.
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PubMed Mentions:
111 Fields:
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AnimalsCells
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Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007 Aug 03; 317(5838):670-4.
Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. PMID: 17673664.
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112 Fields:
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AnimalsCells
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CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature. 2006 Mar 23; 440(7083):540-4.
Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M. PMID: 16525420.
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470 Fields:
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HumansAnimalsCells
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Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 09; 309(5741):1735-9.
Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. PMID: 16151014.
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PubMed Mentions:
331 Fields:
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AnimalsCells
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Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol. 2004 Jul; 5(7):713-20.
Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG. PMID: 15184895.
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144 Fields:
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AnimalsCells
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22; 427(6972):355-60.
Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. PMID: 14737169.
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877 Fields:
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AnimalsCells
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Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33.
Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. PMID: 12077273.
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PubMed Mentions:
161 Fields:
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AnimalsCells
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Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection. J Immunol. 2001 Oct 15; 167(8):4566-73.
Wu-Hsieh BA, Whitmire JK, de Fries R, Lin JS, Matloubian M, Ahmed R. PMID: 11591785.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct; 1(4):298-304.
Matloubian M, David A, Engel S, Ryan JE, Cyster JG. PMID: 11017100.
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177 Fields:
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HumansAnimalsCells
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A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol. 1999 Mar; 73(3):2527-36.
Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, Walsh CM, Clark WR, Ahmed R. PMID: 9971838.
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PubMed Mentions:
56 Fields:
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AnimalsCells
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Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 1996 Dec 15; 157(12):5543-54.
van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R. PMID: 8955205.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes. J Virol. 1996 May; 70(5):2902-10.
Slifka MK, Shen H, Matloubian M, Jensen ER, Miller JF, Ahmed R. PMID: 8627765.
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PubMed Mentions:
16 Fields:
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AnimalsCells
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Mechanisms of CTL-mediated cytoxicity. Seminars in Virology. 1996 Apr 1; 7(2):113-116.
William R. Clark, Craig M. Walsh, Mehrdad Matloubian, Alison A. Glass, Fumitaka Hayashi. .
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Molecular pathways of CTL-mediated cytotoxicity. Immunol Rev. 1995 Aug; 146:33-44.
Clark WR, Walsh CM, Glass AA, Hayashi F, Matloubian M, Ahmed R. PMID: 7493758.
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12 Fields:
Translation:
AnimalsCells
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Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):3987-91.
Shen H, Slifka MK, Matloubian M, Jensen ER, Ahmed R, Miller JF. PMID: 7732018.
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PubMed Mentions:
93 Fields:
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AnimalsCells
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Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol. 1995 Mar; 69(3):1895-902.
Slifka MK, Matloubian M, Ahmed R. PMID: 7853531.
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PubMed Mentions:
130 Fields:
Translation:
AnimalsCells
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Cell-mediated cytotoxicity in perforin-less mice. Int Rev Immunol. 1995; 13(1):1-14.
Clark WR, Walsh CM, Glass AA, Huang MT, Ahmed R, Matloubian M. PMID: 7494105.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol. 1994 Dec; 68(12):8056-63.
Matloubian M, Concepcion RJ, Ahmed R. PMID: 7966595.
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422 Fields:
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AnimalsCells
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Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10854-8.
Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR. PMID: 7526382.
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PubMed Mentions:
150 Fields:
Translation:
AnimalsCells
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Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J Virol. 1993 Dec; 67(12):7340-9.
Matloubian M, Kolhekar SR, Somasundaram T, Ahmed R. PMID: 7693969.
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97 Fields:
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AnimalsCells
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Molecular basis of organ-specific selection of viral variants during chronic infection. J Virol. 1991 Aug; 65(8):4242-7.
Ahmed R, Hahn CS, Somasundaram T, Villarete L, Matloubian M, Strauss JH. PMID: 2072451.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. J Exp Med. 1990 Oct 01; 172(4):1043-8.
Matloubian M, Somasundaram T, Kolhekar SR, Selvakumar R, Ahmed R. PMID: 2212940.
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59 Fields:
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AnimalsCells
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Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus. J Virol. 1988 Sep; 62(9):3301-8.
Ahmed R, Simon RS, Matloubian M, Kolhekar SR, Southern PJ, Freedman DM. PMID: 3261347.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells