Loading...

Charles Craik, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th St
San Francisco CA 94158
Phone415-476-6757
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    National Honor Society1972  - 1975Alden Scholar
    Phi Beta Kappa1974  - 1975Doane Distinguished Scholar
    1975  - 1975Richard Edwin Lee Scholar
    The Amer. Assoc. for the Advan. of Science1978  - 1978Member, The Amer. Chem. Soc
    American Cancer Society 1982  - 1983Postdoctoral Fellow
    American Society of Biological Chemists1983  - 1983Member
    National Institutes of Health1983  - 1984Postdoctoral Fellow
    Science Digest1985  - 1986Top 100 Innovators
    BioTechniques1987  - 1997Editorial Board Member
    DNA1988  - 1988Editorial Board Member
    Protein Engineering1988  - 1988Associate Editor
    Applied Biocatalysis1989  - 1989Editorial Board Member
    Member, The Protein Society1989  - 1990Nominating Committee
    Sigma Xi1991  - 1994Distinguished Lecturer
    National Science Foundation Molecular Biochemistry1993  - 1996Advisory Panel
    Gordon Conference on Proteolytic Enzymes and Inhibitors1996  - 1996Vice Chair
    Gordon Conference on Proteolytic Enzymes and Inhibitors1998  - 1998Chair
    Cold Spring Harbor Meeting on the Biology of Proteolysis1997  - 1997Co-organizer
    Cold Spring Harbor Meeting on the Biology of Proteolysis1999  - 1999Co-organizer
    Cold Spring Harbor Meeting on the Biology of Proteolysis2001  - 2001Co-organizer
    Immunex Corporation (Seattle, WA)2000  - 2000POSH Lecturer
    United States Pharmacopeia2009Council of Experts
    Allegheney College (Meadville, PA)2010  - 2010Lord Lecturer
    American Association for the Advancement of Science2011  - 2011Fellow
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic2013  - 2013Institute Medal Lecture and Award

    Collapse Overview 
    Collapse Overview
    My research focuses on structure-function analysis of proteases and their inhibitors. In my lab we use a combination of genetic, biochemical, and biophysical methods, with particular emphasis on identifying the roles and regulating the activity of proteases associated with infectious diseases, cancer, and development.

    Proteases are directly or indirectly involved in virtually every biological function or dysfunction. The omnipresence of proteases and their natural inhibitors has placed them among the most studied proteins in biochemistry. The research efforts of the lab focus primarily on the structure-function analysis of proteases and their inhibitors using a combination of genetic, biochemical and biophysical methods. Chemical biological approaches are used or are being developed to study the substrate specificity, catalytic mechanism and biological role of proteases and their macromolecular inhibitors. The genes for serine (trypsin, serine collagenase, easter, prostate specific antigen, T-cell specific granzymes, MT-SP1 and 2, KSHV protease), cysteine (cruzain and falcipain) and aspartyl (HIV1 & HIV2 & SIV) proteases and macromolecular inhibitors such as ecotin and single chain antibodies are manipulated and expressed in heterologous expression systems. Targeted, region specific or random substitutions are introduced recombinantly to create variants that provide insight into the structure and activity of the target protein. A particular emphasis of our work is on identifying the roles and regulating the activity of proteases associated with infectious diseases, cancer and development. These studies are providing a better understanding of both the chemical make-up and the biological importance of these critical proteins. This in turn is leading to the development of strategies for regulating proteolytic activity as a means of therapeutic intervention. Further study of these proteins holds promise for better understanding, rapid detection and eventual control of infectious diseases and cancer.

    Collapse Research 
    Collapse Research Activities and Funding
    Mapping the conformational cycle of transmembrane transporters
    NIH/NIGMS P01GM111126Aug 1, 2015 - Jul 31, 2020
    Role: Co-Investigator
    Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer
    NIH/NCI R21CA185689Jan 1, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Antibody Research Technology Center
    NIH/NCI P41CA196276Sep 24, 2014 - Aug 31, 2019
    Role: Co-Investigator
    Extracellular Proteolysis as a Molecular Stratification Tool for Cancer
    NIH/NCI R21CA186077Apr 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Allosteric Inhibition of a Family of Proteolytic Enzymes
    NIH/NIGMS R01GM104659Jul 10, 2013 - Mar 31, 2017
    Role: Principal Investigator
    A Technological Platform for the Identification of Serine Proteases in Cancer
    NIH/NCI R01CA128765Jul 17, 2009 - Jun 30, 2014
    Role: Principal Investigator
    HARC Center: HIV Accessory and Regulatory Complexes
    NIH/NIGMS P50GM082250Aug 27, 2007 - Sep 19, 2012
    Role: Co-Investigator
    Targeting Allosteric Studies to Modulate Protein Interactions and Function
    NIH/NIAID R01AI067423Apr 17, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Research Training in Chemistry and Chemical Biology
    NIH/NIGMS T32GM064337Jul 1, 2002 - Jun 30, 2022
    Role: Principal Investigator
    SFSU/UCSF Comprehensive Cancer Partnership Program
    NIH/NCI U56CA096216Jul 1, 2002 - Jun 30, 2010
    Role: Co-Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 1, 1998 - Nov 30, 2002
    Role: Co-Principal Investigator
    Structure Biology and Targeted Drug Design for AIDS
    NIH/NIGMS P01GM056531Sep 1, 1997 - Aug 31, 2007
    Role: Co-Investigator
    Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    NIH/NIAID P01AI035707May 1, 1995 - May 31, 2010
    Role: Co-Investigator
    STRUCTURAL BIOLOGY AND TARGETED DRUG DESIGN FOR AIDS
    NIH/NIGMS P01GM039552May 1, 1988 - Aug 31, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization. bioRxiv. 2020 Jul 15. Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. PMID: 32699850.
      View in: PubMed   Mentions:
    2. Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms. Front Microbiol. 2020; 11:1027. Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ. PMID: 32523574.
      View in: PubMed   Mentions:
    3. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Apr 30. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes. Sci Rep. 2020 Apr 03; 10(1):5894. Vasiljeva O, Menendez E, Nguyen M, Craik CS, Michael Kavanaugh W. PMID: 32246002.
      View in: PubMed   Mentions: 1     Fields:    
    5. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329.
      View in: PubMed   Mentions:
    6. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin. Front Cell Infect Microbiol. 2020; 10:66. Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L. PMID: 32175287.
      View in: PubMed   Mentions:    Fields:    
    7. Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes. Transplantation. 2020 Jan; 104(1):54-60. Harel E, Shoji J, Abraham V, Miller L, Laszik ZG, King A, Dobi D, Szabo G, Hann B, Sarwal MM, Craik CS, Vincenti F. PMID: 31449183.
      View in: PubMed   Mentions:    Fields:    
    8. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biol Chem. 2019 11 26; 400(12):1629-1638. Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 31256057.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. End-Binding E3 Ubiquitin Ligases Enable Protease Signaling. ACS Chem Biol. 2019 Nov 20. Ravalin M, Basu K, Gestwicki JE, Craik CS. PMID: 31714737.
      View in: PubMed   Mentions:    Fields:    
    10. Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 05; 8(4). Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS. PMID: 31694242.
      View in: PubMed   Mentions:
    11. KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. Am J Pathol. 2019 10; 189(10):1916-1932. Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ. PMID: 31404541.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat Chem Biol. 2019 08; 15(8):786-794. Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. PMID: 31320752.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Why recombinant antibodies - benefits and applications. Curr Opin Biotechnol. 2019 12; 60:153-158. Basu K, Green EM, Cheng Y, Craik CS. PMID: 30849700.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    14. Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation. Clin Transplant. 2019 03; 33(3):e13487. Harel E, Shoji J, Abraham V, Miller L, Laszik Z, Thurison T, King A, Olshen A, Leung J, Szabo G, Hann B, Høyer-Hansen G, Craik CS, Vincenti F. PMID: 30689221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH. J Mol Biol. 2019 03 01; 431(5):1038-1047. Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW. PMID: 30690031.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. J Med Chem. 2019 01 24; 62(2):480-490. Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant SM, Helander J, Klefström J, Craik CS, Janetka JW. PMID: 30571119.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition. PLoS One. 2018; 13(11):e0206654. Schneidman-Duhovny D, Khuri N, Dong GQ, Winter MB, Shifrut E, Friedman N, Craik CS, Pratt KP, Paz P, Aswad F, Sali A. PMID: 30399156.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry. 2018 10 30; 57(43):6201-6208. Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C. PMID: 30289692.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. A Preclinical Assessment of 89Zr-atezolizumab Identifies a Requirement for Carrier Added Formulations Not Observed with 89Zr-C4. Bioconjug Chem. 2018 10 17; 29(10):3476-3482. Moroz A, Lee CY, Wang YH, Hsiao JC, Sevillano N, Truillet C, Craik CS, Fong L, Wang CI, Evans MJ. PMID: 30227708.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Sci Rep. 2018 Jul 16; 8(1):10705. Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P. PMID: 30013126.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    21. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J Am Chem Soc. 2018 05 30; 140(21):6518-6521. Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C. PMID: 29762030.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. PLoS Negl Trop Dis. 2018 04; 12(4):e0006446. Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M. PMID: 29677188.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596.
      View in: PubMed   Mentions:
    24. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 01; 14(1):e1006830. Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. PMID: 29304101.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. PMID: 29236684.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    26. Global substrate specificity profiling of post-translational modifying enzymes. Protein Sci. 2018 03; 27(3):584-594. Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS. PMID: 29168252.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. Elife. 2017 11 28; 6. Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS. PMID: 29182146.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Imaging PD-L1 Expression with ImmunoPET. Bioconjug Chem. 2018 01 17; 29(1):96-103. Truillet C, Oh HLJ, Yeo SP, Lee CY, Huynh LT, Wei J, Parker MFL, Blakely C, Sevillano N, Wang YH, Shen YS, Olivas V, Jami KM, Moroz A, Jego B, Jaumain E, Fong L, Craik CS, Chang AJ, Bivona TG, Wang CI, Evans MJ. PMID: 29125731.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    29. Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2. J Mol Biol. 2017 11 24; 429(23):3666-3677. Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ. PMID: 28942089.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. J Am Chem Soc. 2017 08 30; 139(34):11650-11653. Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS. PMID: 28759216.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thromb Haemost. 2017 08 30; 117(9):1750-1760. Kara E, Manna D, Løset GÅ, Schneider EL, Craik CS, Kanse S. PMID: 28726978.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms. Arthritis Rheumatol. 2017 08; 69(8):1601-1611. Wilkinson DJ, Wang H, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD. PMID: 28464560.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    33. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. ACS Chem Biol. 2017 06 16; 12(6):1556-1565. Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW. PMID: 28414448.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    34. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 28424202.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    35. Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents. Eur J Med Chem. 2017 Jul 28; 135:213-229. Lourenço AL, Salvador RRS, Silva LA, Saito MS, Mello JFR, Cabral LM, Rodrigues CR, Vera MAF, Muri EMF, de Souza AMT, Craik CS, Dias LRS, Castro HC, Sathler PC. PMID: 28453995.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    36. Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs. Anal Chem. 2017 04 18; 89(8):4550-4558. Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS. PMID: 28322550.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 01 26; 168(3):517-526.e18. Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. PMID: 28111075.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    38. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLoS Pathog. 2016 Dec; 12(12):e1006051. Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. PMID: 27977806.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    39. Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23. BMC Bioinformatics. 2016 Nov 23; 17(1):481. Barkan DT, Cheng XL, Celino H, Tran TT, Bhandari A, Craik CS, Sali A, Smythe ML. PMID: 27881076.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    40. Global Identification of Biofilm-Specific Proteolysis in Candida albicans. mBio. 2016 09 13; 7(5). Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ. PMID: 27624133.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors. Biol Chem. 2016 09 01; 397(9):871-81. O'Donoghue AJ, Ivry SL, Chaudhury C, Hostetter DR, Hanahan D, Craik CS. PMID: 27149201.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 08; 10(8):e0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. PMID: 27501047.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. Label-Free Electrical Detection of Enzymatic Reactions in Nanochannels. ACS Nano. 2016 08 23; 10(8):7476-84. Duan C, Alibakhshi MA, Kim DK, Brown CM, Craik CS, Majumdar A. PMID: 27472431.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    44. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. ACS Infect Dis. 2016 11 11; 2(11):807-815. Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. PMID: 27739665.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. Intracellular Action of a Secreted Peptide Required for Fungal Virulence. Cell Host Microbe. 2016 Jun 08; 19(6):849-64. Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik CS, Madhani HD. PMID: 27212659.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    46. Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling. Blood. 2016 06 23; 127(25):3260-9. Le Gall SM, Szabo R, Lee M, Kirchhofer D, Craik CS, Bugge TH, Camerer E. PMID: 27114461.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    47. Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase. ACS Chem Biol. 2016 06 17; 11(6):1587-94. Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ. PMID: 27008570.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500.
      View in: PubMed   Mentions: 16     Fields:    
    49. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 2016 Feb 11; 530(7589):233-6. Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. PMID: 26863983.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    50. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. ChemMedChem. 2016 Apr 19; 11(8):862-9. Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. PMID: 26822284.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    51. Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion. Mar Biotechnol (NY). 2016 Apr; 18(2):201-14. Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F. PMID: 26613762.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    52. Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity. mBio. 2015 Nov 24; 6(6):e01604-15. Jones SK, Clarke SC, Craik CS, Bennett RJ. PMID: 26604258.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    53. In vivo imaging of protease activity by Probody therapeutic activation. Biochimie. 2016 Mar; 122:62-7. Wong KR, Menendez E, Craik CS, Kavanaugh WM, Vasiljeva O. PMID: 26546838.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. PMID: 26423607.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    55. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. PMID: 26409899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    56. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7478-83. O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. PMID: 25944934.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    57. Ecotin: Exploring a feasible antithrombotic profile. Int J Biol Macromol. 2015 Jul; 78:296-303. Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB. PMID: 25881959.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    58. Imaging active urokinase plasminogen activator in prostate cancer. Cancer Res. 2015 Apr 01; 75(7):1225-35. LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF. PMID: 25672980.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    59. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor. Biochem J. 2015 Jan 01; 465(1):163-73. Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. PMID: 25279554.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    60. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature. 2015 Jan 15; 517(7534):396-400. Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. PMID: 25363761.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    61. Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. J Biol Chem. 2014 Dec 05; 289(49):34267-83. Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P. PMID: 25326387.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    62. Cullin E3 ligases and their rewiring by viral factors. Biomolecules. 2014 Oct 13; 4(4):897-930. Mahon C, Krogan NJ, Craik CS, Pick E. PMID: 25314029.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    63. Current and potential treatments for ubiquitous but neglected herpesvirus infections. Chem Rev. 2014 Nov 26; 114(22):11382-412. Gable JE, Acker TM, Craik CS. PMID: 25275644.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    64. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. ACS Nano. 2014 Sep 23; 8(9):9199-208. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS. PMID: 25166742.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    65. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014 Nov; 4(11):1310-25. Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, Simon JA, Bedalov A, Nelson PS. PMID: 25122198.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    66. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. PMID: 24977643.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    67. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. J Biol Chem. 2014 May 02; 289(18):12791-804. Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. PMID: 24644284.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance. Theranostics. 2014; 4(3):267-79. LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF. PMID: 24505235.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    69. Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology. Methods Enzymol. 2014; 544:271-97. Tajon C, Jun YW, Craik CS. PMID: 24974294.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    70. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discov. 2014 Feb; 4(2):200-15. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. PMID: 24362263.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    71. Elastin degradation by cathepsin V requires two exosites. J Biol Chem. 2013 Nov 29; 288(48):34871-81. Du X, Chen NL, Wong A, Craik CS, Brömme D. PMID: 24121514.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    72. Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. PLoS One. 2013; 8(9):e75141. O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. PMID: 24073241.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    73. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. PMID: 23875031.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    74. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. J Biol Chem. 2013 May 03; 288(18):12489-99. Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. PMID: 23504313.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    75. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013 Apr 12; 288(15):10588-98. Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH. PMID: 23447538.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    76. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res. 2013 Apr 01; 73(7):2070-81. LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS. PMID: 23400595.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    77. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):93-8. LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS. PMID: 23248318.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    78. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18; 51(50):10087-98. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. PMID: 23181936.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    79. Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods. 2012 Nov; 9(11):1095-100. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. PMID: 23023596.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    80. Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L97-106. Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH. PMID: 22582115.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    81. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. PMID: 22539347.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    82. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. PMID: 22483106.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    83. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis. 2012; 6(4):e1589. Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. PMID: 22509414.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    84. Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference. Biochimie. 2012 May; 94(5):1119-27. Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV, Smooker PM. PMID: 22285967.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    85. A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor. Methods Mol Biol. 2012; 928:119-31. Craik CS, Shahian T. PMID: 22956137.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    86. Global landscape of HIV-human protein complexes. Nature. 2011 Dec 21; 481(7381):365-70. Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ. PMID: 22190034.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansCells
    87. Vif hijacks CBF-ß to degrade APOBEC3G and promote HIV-1 infection. Nature. 2011 Dec 21; 481(7381):371-5. Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, Sali A, Craik CS, Harris RS, Gross JD, Krogan NJ. PMID: 22190037.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    88. A reverse binding motif that contributes to specific protease inhibition by antibodies. J Mol Biol. 2012 Jan 27; 415(4):699-715. Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS. PMID: 22154938.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    89. Rapid identification of recombinant Fabs that bind to membrane proteins. Methods. 2011 Dec; 55(4):303-9. Kim J, Stroud RM, Craik CS. PMID: 21958987.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    90. Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis. Prostate. 2012 Jun 01; 72(8):846-55. Ray M, Hostetter DR, Loeb CR, Simko J, Craik CS. PMID: 21919028.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    91. Human and mouse granzyme M display divergent and species-specific substrate specificities. Biochem J. 2011 Aug 01; 437(3):431-42. de Poot SA, Westgeest M, Hostetter DR, Van Damme P, Plasman K, Demeyer K, Broekhuizen R, Gevaert K, Craik CS, Bovenschen N. PMID: 21564021.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    92. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Res. 2011 Nov; 92(2):187-94. Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G. PMID: 21820471.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    93. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. PMID: 21819989.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    94. GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data. BMC Bioinformatics. 2011 Jul 22; 12:298. Fahey ME, Bennett MJ, Mahon C, Jäger S, Pache L, Kumar D, Shapiro A, Rao K, Chanda SK, Craik CS, Frankel AD, Krogan NJ. PMID: 21777475.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    95. Enzyme inhibition by allosteric capture of an inactive conformation. J Mol Biol. 2011 Sep 02; 411(5):999-1016. Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. PMID: 21723875.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    96. Proteases as therapeutics. Biochem J. 2011 Apr 01; 435(1):1-16. Craik CS, Page MJ, Madison EL. PMID: 21406063.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    97. Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors. Chem Biol. 2011 Jan 28; 18(1):48-57. Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS. PMID: 21276938.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    98. Mechanisms of macromolecular protease inhibitors. Chembiochem. 2010 Nov 22; 11(17):2341-6. Farady CJ, Craik CS. PMID: 21053238.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    99. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J Biol Chem. 2011 Jan 07; 286(1):429-40. Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. PMID: 20961853.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    100. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis. 2010 Oct 12; 4(10):e849. Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. PMID: 20967286.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    101. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. J Immunol. 2010 Nov 01; 185(9):5360-8. Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. PMID: 20889553.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    102. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors. 2010 Jul 27; 3:63. Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S. PMID: 20663211.
      View in: PubMed   Mentions: 12     Fields:    
    103. Prediction of protease substrates using sequence and structure features. Bioinformatics. 2010 Jul 15; 26(14):1714-22. Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. PMID: 20505003.
      View in: PubMed   Mentions: 22     Fields:    
    104. Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. J Biol Chem. 2010 Aug 27; 285(35):26878-88. Duriseti S, Goetz DH, Hostetter DR, LeBeau AM, Wei Y, Craik CS. PMID: 20501655.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    105. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11; 285(24):18516-27. He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. PMID: 20378535.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    106. Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation. Biol Chem. 2010 Apr; 391(4):425-33. Stoop AA, Joshi RV, Eggers CT, Craik CS. PMID: 20180651.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    107. Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer. Biol Chem. 2010 Apr; 391(4):333-43. LeBeau AM, Kostova M, Craik CS, Denmeade SR. PMID: 20180648.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    108. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host Microbe. 2010 Mar 18; 7(3):210-20. Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS. PMID: 20227664.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    109. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. ACS Nano. 2010 Feb 23; 4(2):978-84. Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X. PMID: 20121209.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    110. Tumor detection by imaging proteolytic activity. Cancer Res. 2010 Feb 15; 70(4):1505-12. Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. PMID: 20145119.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    111. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19; 18(1):25-38. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR. PMID: 20152175.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    112. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17735-40. Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP. PMID: 19805121.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    113. Engineering ecotin for identifying proteins with a trypsin fold. Appl Biochem Biotechnol. 2010 Apr; 160(8):2355-65. Sathler PC, Craik CS, Takeuchi T, Zingali RB, Castro HC. PMID: 19728173.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    114. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol. 2009 Sep; 5(9):640-6. Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. PMID: 19633659.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    115. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. PMID: 19620707.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    116. Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz. 2009 Jul; 104 Suppl 1:263-9. McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. PMID: 19753483.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    117. Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology. 2009 Nov; 155(Pt 11):3673-3682. Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. PMID: 19556294.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    118. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009 Jun 02; 3(6):e449. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. PMID: 19488406.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    119. Improving the species cross-reactivity of an antibody using computational design. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3744-7. Farady CJ, Sellers BD, Jacobson MP, Craik CS. PMID: 19477127.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    120. Substrate specificity of transthyretin: identification of natural substrates in the nervous system. Biochem J. 2009 Apr 15; 419(2):467-74. Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM. PMID: 19138167.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    121. Trapping moving targets with small molecules. Science. 2009 Apr 10; 324(5924):213-5. Lee GM, Craik CS. PMID: 19359579.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    122. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. PLoS One. 2009; 4(4):e5156. Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. PMID: 19357776.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    123. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. J Biol Chem. 2009 May 15; 284(20):13792-803. Lilla JN, Joshi RV, Craik CS, Werb Z. PMID: 19297327.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    124. Positional scanning synthetic combinatorial libraries for substrate profiling. Methods Mol Biol. 2009; 539:59-78. Schneider EL, Craik CS. PMID: 19377970.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    125. Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array. Nano Lett. 2008 Sep; 8(9):2968-74. Raorane DA, Lim MD, Chen FF, Craik CS, Majumdar A. PMID: 18720973.
      View in: PubMed   Mentions: 4     Fields:    
    126. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. PMID: 18701454.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    127. Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. J Biol Chem. 2008 Oct 24; 283(43):29186-95. O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG. PMID: 18687686.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    128. The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti. Int J Parasitol. 2009 Jan; 39(2):201-11. Dolecková K, Kasný M, Mikes L, Cartwright J, Jedelský P, Schneider EL, Dvorák J, Mountford AP, Craik CS, Horák P. PMID: 18708063.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    129. Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis. Arch Biochem Biophys. 2008 Sep 15; 477(2):239-43. Lucas JJ, Hayes GR, Kalsi HK, Gilbert RO, Choe Y, Craik CS, Singh BN. PMID: 18554499.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    130. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7. Biol Chem. 2008 Jun; 389(6):623-32. Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P. PMID: 18627343.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    131. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. J Mol Biol. 2008 Jul 04; 380(2):351-60. Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS. PMID: 18514224.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    132. Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27; 283(26):18024-31. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. PMID: 18445589.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    133. Using specificity to strategically target proteases. Bioorg Med Chem. 2009 Feb 01; 17(3):1094-100. Lim MD, Craik CS. PMID: 18434168.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    134. MT-SP1 proteolysis and regulation of cell-microenvironment interactions. Front Biosci. 2008 Jan 01; 13:528-39. Darragh MR, Bhatt AS, Craik CS. PMID: 17981566.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    135. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11; 283(15):9896-908. Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. PMID: 18160404.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    136. Substrate modulation of enzyme activity in the herpesvirus protease family. J Mol Biol. 2007 Nov 02; 373(4):913-23. Lazic A, Goetz DH, Nomura AM, Marnett AB, Craik CS. PMID: 17870089.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    137. Hip is a pro-survival substrate of granzyme B. J Biol Chem. 2007 Sep 21; 282(38):27865-74. Hostetter DR, Loeb CR, Chu F, Craik CS. PMID: 17620340.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    138. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. Biochemistry. 2007 Jul 31; 46(30):8744-52. Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. PMID: 17605471.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    139. Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity. J Nanosci Nanotechnol. 2007 Jul; 7(7):2323-30. Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP. PMID: 17663247.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    140. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. PMID: 17513563.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    141. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). J Mol Biol. 2007 Jun 15; 369(4):1041-51. Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS. PMID: 17475279.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    142. Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5771-6. Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS. PMID: 17389401.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    143. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun; 37(7):713-24. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. PMID: 17336985.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    144. Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces. J Am Chem Soc. 2006 Aug 16; 128(32):10362-3. Chu F, Mahrus S, Craik CS, Burlingame AL. PMID: 16895390.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    145. Expression and characterization of constitutively active human caspase-14. Biochem Biophys Res Commun. 2006 Sep 08; 347(4):941-8. Park K, Kuechle MK, Choe Y, Craik CS, Lawrence OT, Presland RB. PMID: 16854378.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    146. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. J Biol Chem. 2006 Sep 22; 281(38):28326-35. Loeb CR, Harris JL, Craik CS. PMID: 16798735.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    147. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J. 2006 Jun 21; 25(12):2686-97. Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J. PMID: 16763560.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    148. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. J Biol Chem. 2006 Sep 01; 281(35):25678-88. Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P. PMID: 16740631.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    149. Ecotin modulates thrombin activity through exosite-2 interactions. Int J Biochem Cell Biol. 2006; 38(11):1893-900. Castro HC, Monteiro RQ, Assafim M, Loureiro NI, Craik C, Zingali RB. PMID: 16843700.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    150. Conversion of trypsin to a functional threonine protease. Protein Sci. 2006 Jun; 15(6):1229-38. Baird TT, Wright WD, Craik CS. PMID: 16672242.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    151. One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease. Biochemistry. 2006 Mar 21; 45(11):3572-9. Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS. PMID: 16533039.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    152. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem. 2006 May 05; 281(18):12824-32. Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. PMID: 16520377.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    153. Induced structure of a helical switch as a mechanism to regulate enzymatic activity. Nat Struct Mol Biol. 2005 Nov; 12(11):1019-20. Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS. PMID: 16244665.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    154. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem J. 2005 Aug 15; 390(Pt 1):125-36. Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ. PMID: 15839837.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    155. Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene. 2005 Aug 11; 24(34):5333-43. Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM. PMID: 16007225.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    156. Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells. Chem Biol. 2005 May; 12(5):567-77. Mahrus S, Craik CS. PMID: 15911377.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    157. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. Bioorg Med Chem. 2005 Mar 15; 13(6):2141-56. Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS. PMID: 15727867.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    158. Papa's got a brand new tag: advances in identification of proteases and their substrates. Trends Biotechnol. 2005 Feb; 23(2):59-64. Marnett AB, Craik CS. PMID: 15661339.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    159. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate. 2005 Jan 01; 62(1):1-13. Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS. PMID: 15389820.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    160. Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. J Biol Chem. 2004 Dec 24; 279(52):54275-82. Mahrus S, Kisiel W, Craik CS. PMID: 15494398.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    161. Optimization of 13C direct detection NMR methods. J Biomol NMR. 2004 Oct; 30(2):175-9. Shimba N, Kovacs H, Stern AS, Nomura AM, Shimada I, Hoch JC, Craik CS, Dötsch V. PMID: 15557804.
      View in: PubMed   Mentions: 8     Fields:    
    162. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. PMID: 15199048.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    163. Methyl groups as probes for proteins and complexes in in-cell NMR experiments. J Am Chem Soc. 2004 Jun 09; 126(22):7119-25. Serber Z, Straub W, Corsini L, Nomura AM, Shimba N, Craik CS, Ortiz de Montellano P, Dötsch V. PMID: 15174883.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    164. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem. 2004 Jul 16; 279(29):30751-9. Ruggles SW, Fletterick RJ, Craik CS. PMID: 15123647.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    165. Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):6870-5. Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS. PMID: 15118083.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    166. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 01; 379(Pt 1):107-18. Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. PMID: 14705961.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    167. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochem J. 2004 Mar 01; 378(Pt 2):529-38. Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. PMID: 14629194.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    168. 2004; 12(78):6657-65 . Shimba, N. Nomura, A.M., Marnett, A.B. and Craik, C.S. Herpesvirus Protease Inhibition by Dimer Disruption. J. Virol.
    169. 2004; 2nd Ed. Brachyurins. Tsu, C., and Craik, C.S. Handbook of Proteolytic Enzymes .
    170. Engineering of a macromolecular scaffold to develop specific protease inhibitors. Nat Biotechnol. 2003 Sep; 21(9):1063-8. Stoop AA, Craik CS. PMID: 12923547.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    171. Quantitative identification of the protonation state of histidines in vitro and in vivo. Biochemistry. 2003 Aug 05; 42(30):9227-34. Shimba N, Serber Z, Ledwidge R, Miller SM, Craik CS, Dötsch V. PMID: 12885258.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    172. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol. 2003 Jul; 10(7):527-34. Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. PMID: 12819769.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    173. Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. J Biol Chem. 2003 Sep 05; 278(36):34517-24. Raymond WW, Ruggles SW, Craik CS, Caughey GH. PMID: 12815038.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    174. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem J. 2003 Apr 15; 371(Pt 2):525-32. Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA. PMID: 12529175.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    175. The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3433-8. Mackewicz CE, Craik CS, Levy JA. PMID: 12624186.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    176. Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction. J Am Chem Soc. 2003 Mar 05; 125(9):2382-3. Shimba N, Stern AS, Craik CS, Hoch JC, Dötsch V. PMID: 12603112.
      View in: PubMed   Mentions: 21     Fields:    
    177. Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies. Biochemistry. 2003 Feb 04; 42(4):892-900. Sun J, Pons J, Craik CS. PMID: 12549907.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    178. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. Biol Chem. 2003 Feb; 384(2):257-66. Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS. PMID: 12675519.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    179. Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorg Med Chem Lett. 2002 Dec 16; 12(24):3619-23. Barrios AM, Craik CS. PMID: 12443789.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    180. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochem J. 2002 Nov 15; 368(Pt 1):273-81. Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. PMID: 12169096.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    181. Design and synthesis of novel inhibitors of gelatinase B. Bioorg Med Chem Lett. 2002 Aug 19; 12(16):2201-4. Wang X, Choe Y, Craik CS, Ellman JA. PMID: 12127537.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    182. Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity. Biochemistry. 2002 Jul 02; 41(26):8447-54. Lecaille F, Choe Y, Brandt W, Li Z, Craik CS, Brömme D. PMID: 12081494.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    183. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002 Jul 05; 277(27):24618-24. Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. PMID: 11986325.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    184. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    185. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem. 2002 Jul 19; 277(29):26623-31. Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. PMID: 11959867.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    186. Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. Biochemistry. 2002 Apr 09; 41(14):4582-94. Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM. PMID: 11926820.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    187. Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction. Biochemistry. 2002 Feb 26; 41(8):2805-13. Wang B, Brown KC, Lodder M, Craik CS, Hecht SM. PMID: 11851428.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    188. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. J Org Chem. 2002 Feb 08; 67(3):910-5. Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. PMID: 11856036.
      View in: PubMed   Mentions: 27     Fields:    
    189. Conformational change coupling the dimerization and activation of KSHV protease. Biochemistry. 2002 Feb 05; 41(5):1474-82. Pray TR, Reiling KK, Demirjian BG, Craik CS. PMID: 11814340.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    190. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. J Virol. 2002 Feb; 76(3):1359-68. Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS. PMID: 11773410.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    191. Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer. Protein Sci. 2001 Aug; 10(8):1549-62. Person MD, Brown KC, Mahrus S, Craik CS, Burlingame AL. PMID: 11468352.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    192. Definition of the extended substrate specificity determinants for beta-tryptases I and II. J Biol Chem. 2001 Sep 14; 276(37):34941-7. Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. PMID: 11438529.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    193. Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform? Biochim Biophys Acta. 2001 Jun 11; 1547(2):183-95. Castro HC, Silva DM, Craik C, Zingali RB. PMID: 11410274.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    194. The role of ecotin dimerization in protease inhibition. J Mol Biol. 2001 May 18; 308(5):975-91. Eggers CT, Wang SX, Fletterick RJ, Craik CS. PMID: 11352586.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    195. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. J Virol. 2001 Mar; 75(6):2866-78. Nealon K, Newcomb WW, Pray TR, Craik CS, Brown JC, Kedes DH. PMID: 11222712.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    196. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Nat Cell Biol. 2001 Mar; 3(3):267-75. Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z. PMID: 11231576.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    197. Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry. 2000 Oct 24; 39(42):12796-803. Reiling KK, Pray TR, Craik CS, Stroud RM. PMID: 11041844.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    198. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity. Nat Struct Biol. 2000 Sep; 7(9):762-5. Waugh SM, Harris JL, Fletterick R, Craik CS. PMID: 10966646.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    199. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem. 2000 Aug 25; 275(34):26333-42. Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. PMID: 10831593.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    200. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7754-9. Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. PMID: 10869434.
      View in: PubMed   Mentions: 121     Fields:    
    201. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. J Mol Biol. 2000 Jun 16; 299(4):993-1003. Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. PMID: 10843853.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    202. Cathepsin G activates protease-activated receptor-4 in human platelets. J Biol Chem. 2000 Mar 10; 275(10):6819-23. Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR. PMID: 10702240.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    203. Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers. J Biol Chem. 2000 Mar 10; 275(10):7080-6. Rozzelle JE, Dauber DS, Todd S, Kelley R, Craik CS. PMID: 10702274.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    204. HIV protease as a target for retrovirus vector-mediated gene therapy. Biochim Biophys Acta. 2000 Mar 07; 1477(1-2):168-88. Todd S, Anderson C, Jolly DJ, Craik CS. PMID: 10708857.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    205. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nat Biotechnol. 2000 Feb; 18(2):187-93. Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. PMID: 10657126.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    206. Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants. Anal Biochem. 2000 Jan 15; 277(2):247-53. Todd S, Laboissière MC, Craik CS. PMID: 10625514.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    207. 2000; 24:12796-803 . K.K. Reiling, T.R. Pray, C.S. Craik, R.M. Stroud. Structure: Regulation of Activity and Dimerization by Conserved Structural Elements. Biochemistry.
    208. 2000; 556:9477-9485 . T.T. Baird Jr., B. Wang, M. Lodder, S.M. Hecht and C.S. Craik. Generation of Active Trypsin by Chemical Cleavage. Tetrahedron Letters..
    209. J. Am. Chem. Soc. Chemically Mediated Site-Specific Cleavage of Proteins. 2000; 122:7402-7403. B. Wang, M. Lodder, J. Zhou, T.T. Baird, Jr., K.C. Brown, C.S. Craik, S.M. Hecht.
    210. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11054-61. Takeuchi T, Shuman MA, Craik CS. PMID: 10500122.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    211. Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease. J Mol Biol. 1999 Jun 04; 289(2):197-203. Pray TR, Nomura AM, Pennington MW, Craik CS. PMID: 10366498.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    212. Definition and redesign of the extended substrate specificity of granzyme B. J Biol Chem. 1998 Oct 16; 273(42):27364-73. Harris JL, Peterson EP, Hudig D, Thornberry NA, Craik CS. PMID: 9765264.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    213. Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator. J Mol Biol. 1998 Jun 19; 279(4):1001-11. Yang SQ, Craik CS. PMID: 9642077.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    214. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. J Mol Biol. 1998 Jun 19; 279(4):945-57. Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. PMID: 9642073.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    215. Determining protein-protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein. Biochemistry. 1998 Mar 31; 37(13):4397-406. Brown KC, Yu Z, Burlingame AL, Craik CS. PMID: 9521759.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    216. Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry. 1998 Feb 24; 37(8):2607-21. Rose RB, Craik CS, Stroud RM. PMID: 9485411.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    217. Engineering enzyme specificity. Curr Opin Chem Biol. 1998 Feb; 2(1):127-32. Harris JL, Craik CS. PMID: 9667915.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    218. Optimization of a macromolecular inhibitor of HIV-1 protease. Adv Exp Med Biol. 1998; 436:65-70. Dauber DS, McPhee F, Unal A, Craik CS. PMID: 9561201.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    219. Engineering catalytically defective forms of HIV protease to modulate its activity. Adv Exp Med Biol. 1998; 436:31-9. Craik CS, Babé LM, Dauber D, McPhee F, Rosé J, Unal A. PMID: 9561196.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    220. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold. J Biol Chem. 1997 Nov 28; 272(48):29987-90. Perona JJ, Craik CS. PMID: 9374470.
      View in: PubMed   Mentions: 82     Fields:    Translation:Cells
    221. Viral proteases: evolution of diverse structural motifs to optimize function. Cell. 1997 Nov 14; 91(4):427-30. Babé LM, Craik CS. PMID: 9390549.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    222. Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor. Bioorg Med Chem. 1997 Nov; 5(11):2019-27. Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR. PMID: 9416419.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    223. The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol. 1997 Sep; 71(9):7030-8. Unal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS. PMID: 9261433.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    224. Structural determinants of specificity in the cysteine protease cruzain. Protein Sci. 1997 Aug; 6(8):1603-11. Gillmor SA, Craik CS, Fletterick RJ. PMID: 9260273.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    225. The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. Bioorg Med Chem. 1997 Jul; 5(7):1311-20. Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR. PMID: 9377091.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    226. P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes. J Immunol. 1997 May 15; 158(10):4574-83. Ewoldt GR, Smyth MJ, Darcy PK, Harris JL, Craik CS, Horowitz B, Woodard SL, Powers JC, Hudig D. PMID: 9144469.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    227. Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry. 1997 May 06; 36(18):5381-92. Perona JJ, Tsu CA, Craik CS, Fletterick RJ. PMID: 9154920.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    228. Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry. 1997 May 06; 36(18):5393-401. Tsu CA, Perona JJ, Fletterick RJ, Craik CS. PMID: 9154921.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    229. Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein. J Interferon Cytokine Res. 1997 May; 17(5):287-93. Babé LM, Unal A, Craik CS. PMID: 9181467.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    230. Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity. Pharm Res. 1997 Feb; 14(2):176-80. Kågedahl M, Swaan PW, Redemann CT, Tang M, Craik CS, Szoka FC, Oie S. PMID: 9090705.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    231. 1997; 125-126 . C.S. Craik & R.J. Fletterick. The Marriage of Protein Structure and Pharmaceutical Discovery. Biotech. & Appl. Biochem. 26 ..
    232. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. Biochem J. 1996 Dec 01; 320 ( Pt 2):681-6. McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. PMID: 8973584.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    233. Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines. J Virol. 1996 Nov; 70(11):7765-72. Junker U, Escaich S, Plavec I, Baker J, McPhee F, Rose JR, Craik CS, Böhnlein E. PMID: 8892897.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    234. Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11477-81. McPhee F, Good AC, Kuntz ID, Craik CS. PMID: 8876160.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    235. Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry. 1996 Oct 01; 35(39):12933-44. Rose RB, Craik CS, Douglas NL, Stroud RM. PMID: 8841139.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    236. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 1996 May 14; 35(19):5999-6009. Brinen LS, Willett WS, Craik CS, Fletterick RJ. PMID: 8634241.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    237. Substrate recognition by recombinant serine collagenase 1 from Uca pugilator. J Biol Chem. 1996 May 10; 271(19):11563-70. Tsu CA, Craik CS. PMID: 8626718.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    238. Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases. Comp Biochem Physiol B Biochem Mol Biol. 1996 Apr; 113(4):795-801. Gudmundsdóttir E, Spilliaert R, Yang Q, Craik CS, Bjarnason JB, Gudmundsdóttir A. PMID: 8925447.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    239. 1996; 1421-1427. R. Li, X. Chen, B. Gong, Z. Li, E. Davidson, G. Kurzban, R.E. Miller, E.O. Nuzman, J.H. McKerrow, R.J. Fletterick, S.A. Gillmore, C.S. Craik, I.D. Kuntz, F.E. Cohen & G.L. Kenyon. Structure-based Design of Parasitic Protease Inhibitors. Bioorg. & Med. Chem. 4 .
    240. 1996; 1545-1558 . E.E. Rutenber, F. McPhee, A.P. Kaplan, S.L. Gallion, J.C. Hogan Jr., C.S. Craik & R.M. Stroud. A New Class of HIV1 Protease Inhibitor: The Crystallographic Structure, Inhibition and Chemical Synthesis of an Aminimide Peptide Isostere. Bioorg.& Med. Chem. 4.
    241. 1996; 5846-5856. Z. Yu, P. Caldera, F. McPhee, J. DeVoss, P.R. Jones, A. Burlingame, I. Kuntz, C.S. Craik & P.R. Ortiz de Montellano. Irreversible Inhibition of the HIV-1 Protease: Targeting Alkylating Agents to the Catalytic Aspartate Groups. J. Amer. Chem. Soc. 118..
    242. 1996; 1227-1228 . S. Halfon & C.S. Craik. Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding Loops. J. Am. Chem. Soc. 118..
    243. 1996; 5992-5998. W.S. Willett, L.S. Brinen, R.J. Fletterick & C.S. Craik. Delocalizing Trypsin Specificity with Metal-Activation. Biochem; 35..
    244. Phage display of proteases and macromolecular inhibitors. Methods Enzymol. 1996; 267:52-68. Wang CI, Yang Q, Craik CS. PMID: 8743309.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    245. Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10069-73. Babé LM, Rosé J, Craik CS. PMID: 7479728.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    246. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Cell. 1995 Oct 20; 83(2):257-67. Liu SH, Wong ML, Craik CS, Brodsky FM. PMID: 7585943.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    247. Trypsin specificity increased through substrate-assisted catalysis. Biochemistry. 1995 Sep 12; 34(36):11521-7. Corey DR, Willett WS, Coombs GS, Craik CS. PMID: 7547882.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    248. Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin. J Biol Chem. 1995 May 19; 270(20):12250-6. Wang CI, Yang Q, Craik CS. PMID: 7744876.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    249. Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity. J Virol. 1995 May; 69(5):2751-8. Rosé JR, Babé LM, Craik CS. PMID: 7535864.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    250. The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24; 247(2):251-9. McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. PMID: 7707373.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    251. Structural basis of substrate specificity in the serine proteases. Protein Sci. 1995 Mar; 4(3):337-60. Perona JJ, Craik CS. PMID: 7795518.
      View in: PubMed   Mentions: 195     Fields:    Translation:Cells
    252. Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Eng. 1995 Mar; 8(3):275-82. Sloane DL, Leung R, Barnett J, Craik CS, Sigal E. PMID: 7479689.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    253. Engineered metal regulation of trypsin specificity. Biochemistry. 1995 Feb 21; 34(7):2172-80. Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS. PMID: 7857928.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    254. 1995; 29:1501S-1517S. A.E. Eakin, J.H. McKerrow & C.S.Craik. A Cysteine Protease is a Target for the Enzyme Structure-based Design of Antiparasitic Drugs. Drug Information Journal 29.
    255. Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 2):S176-82. Rosé JR, Craik CS. PMID: 7952656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    256. Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation. Antimicrob Agents Chemother. 1994 Oct; 38(10):2430-9. Babé LM, Craik CS. PMID: 7840583.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    257. Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen. Biochim Biophys Acta. 1994 Sep 13; 1219(1):211-4. Guthmundsdóttir A, Oskarsson S, Eakin AE, Craik CS, Bjarnason JB. PMID: 8086467.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    258. The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites. J Biol Chem. 1994 Jul 29; 269(30):19565-72. Tsu CA, Perona JJ, Schellenberger V, Turck CW, Craik CS. PMID: 8034725.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    259. Can small cyclic peptides have the activity and specificity of proteolytic enzymes? Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4103-5. Matthews BW, Craik CS, Neurath H. PMID: 8183878.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    260. In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases. J Biol Chem. 1994 Apr 08; 269(14):10691-8. Salto R, Babé LM, Li J, Rosé JR, Yu Z, Burlingame A, De Voss JJ, Sui Z, Ortiz de Montellano P, Craik CS. PMID: 8144659.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    261. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 1994 Mar 22; 33(11):3252-9. Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. PMID: 8136360.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    262. Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases. J Med Chem. 1994 Mar 04; 37(5):665-73. De Voss JJ, Sui Z, DeCamp DL, Salto R, Babé LM, Craik CS, Ortiz de Montellano PR. PMID: 8126707.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    263. 1994; 6194-6199 . K.L. Lee, F. McPhee, J.J. DeVoss, C.S. Craik & P. Ortiz de Montellano. Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the two Aryl Rings of Haloperidol. J. of Organic Chemistry 59..
    264. A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin. Gene. 1993 Dec 27; 137(1):121-6. Perona JJ, Evnin LB, Craik CS. PMID: 8282194.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    265. Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor. Biochemistry. 1993 Nov 23; 32(46):12498-507. Rose RB, Rosé JR, Salto R, Craik CS, Stroud RM. PMID: 8241141.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    266. Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen. Eur J Biochem. 1993 Nov 01; 217(3):1091-7. Gudmundsdóttir A, Gudmundsdóttir E, Oskarsson S, Bjarnason JB, Eakin AK, Craik CS. PMID: 8223632.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    267. Locating the catalytic water molecule in serine proteases. Science. 1993 Jul 30; 261(5121):620-2. Perona JJ, Craik CS, Fletterick RJ. PMID: 8342029.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    268. Trypsin display on the surface of bacteriophage. Gene. 1993 Jun 15; 128(1):129-34. Corey DR, Shiau AK, Yang Q, Janowski BA, Craik CS. PMID: 8508953.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    269. Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions. J Biol Chem. 1993 Jun 05; 268(16):11939-45. Rosé JR, Salto R, Craik CS. PMID: 8505318.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    270. Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI. J Mol Biol. 1993 Apr 05; 230(3):919-33. Perona JJ, Tsu CA, Craik CS, Fletterick RJ. PMID: 7683059.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    271. Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J Biol Chem. 1993 Mar 25; 268(9):6115-8. Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS. PMID: 8454586.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    272. Structure of an engineered, metal-actuated switch in trypsin. Biochemistry. 1993 Mar 02; 32(8):1914-9. McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ. PMID: 8448149.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    273. 1993; 819-824 . T.K. Sawyer, J.F. Fisher, J.B. Hester, C.W. Smith, A.G. Tomasselli, W.G. Tarpley, P.S. Burton, J.O. Hui T.J. McQuade, R.A. Conradi, V.S. Bradford, L. Liu, J.H. Kinner, J.Tustin, D.L. Alexander, A.W. Harrison, D.E. Emmert, D.J. Staples, L.I. Maggira, Y.Z. Zhang, R.A. Poorman, BM. Dunn, C. Rao, .E. Scarborough, W.T. Lowther, C.S. Craik, D. DeCamp, J.Moon, W.H. Howe & R.L. Heinrikson. Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease (HIV-PR): Design, Enzyme Binding and Selectivity, Antiviral Efficacy and Cell Permeability Properties. Bioorg. Med. Chem. Letts 3.
    274. J. Bio. Chem. Structure of a Non-Peptide Inhibitor Complexed with HIV-1 Protease: Developing a Cycle of Structure-Based Drug Design. 1993; 15343-15346. E. Rutenber, E.B. Fauman, R.J. Keenan, S. Fong, P.S. Furth, P.R. Ortiz de Montellano, E. Meng, I.D. Kuntz, D.L. DeCamp, R. Salto, J.R. Rosé, C.S. Craik, R.M. Stroud.
    275. Synthesis. Synthesis of Haloperidol Ethanedithioketal HIV-1 Protease Inhibitors: Magnesium Chloride Facilitated Addition of Grignard Reagents. 1993; 8:803-808. Z. Sui, J. DeVoss, D. DeCamp, J. Li, C.S. Craik & P.R. Ortiz de Montellano..
    276. 1993; 415-422 . Z. Sui, R. Salto, C.S. Craik, P. Ortiz de Montellano. Inhibition of the HIV1 and the HIV2 Proteases by Curcumin and Curcumin Boron Complexes. Bioorg. & Med. Chem. Let. 1 .
    277. 1993; 19-20 . D.L. Decamp, S.B. Kahl & C.S. Craik. Boronated Porphyrins—A New Class of HIV Proteinase Inhibitors. Intl. Antiviral News 1..
    278. 1993; 934-949. J.J. Perona, C.A. Tsu, M.E. McGrath, C.S. Craik & R.J. Fletterick. Relocating a Negative Charge in the Binding Pocket of Trypsin. J. Mol. Bio. 230..
    279. Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases. Protein Sci. 1992 Oct; 1(10):1244-53. Babé LM, Rosé J, Craik CS. PMID: 1338945.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    280. Specific inhibition of HIV-1 protease by boronated porphyrins. J Med Chem. 1992 Sep 04; 35(18):3426-8. DeCamp DL, Babé LM, Salto R, Lucich JL, Koo MS, Kahl SB, Craik CS. PMID: 1527792.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    281. The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. J Biol Chem. 1992 Apr 15; 267(11):7411-20. Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS. PMID: 1559982.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    282. Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry. 1992 Mar 31; 31(12):3059-64. McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ. PMID: 1554694.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    283. Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin. J Bacteriol. 1992 Mar; 174(5):1704. Erpel T, Hwang P, Craik CS, Fletterick RJ, McGrath ME. PMID: 1537814.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    284. Engineered metalloregulation in enzymes. Trends Biochem Sci. 1992 Mar; 17(3):100-4. Higaki JN, Fletterick RJ, Craik CS. PMID: 1329276.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    285. 1992; 4906-4907 . D.R. Corey, M.E. McGrath, J.R. Vasquez, R.J. Fletterick & C.S. Craik. An Alternate Geometry for the Catalytic Triad of Serine Proteases. J. Amer. Chem. Soc. 114..
    286. Int. J. Pep. Protein Res. HIV Protease (HIV PR) Inhibitor Structure-Activity-Selectivity and Active Site Molecular Modeling of High Affinity Leu [CH(OH)CH2] Val Modified Viral and Nonviral Substrate Analogs. 1992; 274-281 . T.K. Sawyer, D.J. Staples, L. Liu, A.G. Tomasselli, J.O. Hui, K. O’Connell, H. Schostarez, J.B. Hester, J. Moon, W.J. Howe, C.W. Smith, D. L. DeCamp, C.S. Craik, B.M. Dunn, W. T. Lowther, J. Harris, R.A. Poorman, A. Wlodawer, M. Jaskolski & R.L. Heinrikson.
    287. A primary determinant for lipoxygenase positional specificity. Nature. 1991 Nov 14; 354(6349):149-52. Sloane DL, Leung R, Craik CS, Sigal E. PMID: 1944593.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    288. Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis. J Mol Biol. 1991 Jun 05; 219(3):525-32. Wilke ME, Higaki JN, Craik CS, Fletterick RJ. PMID: 2051486.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    289. Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases. J Mol Biol. 1991 Jun 05; 219(3):511-23. Wilke ME, Higaki JN, Craik CS, Fletterick RJ. PMID: 1904942.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    290. The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli. J Biol Chem. 1991 Apr 05; 266(10):6620-5. McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS. PMID: 2007606.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    291. Inhibition of HIV protease activity by heterodimer formation. Biochemistry. 1991 Jan 08; 30(1):106-11. Babé LM, Pichuantes S, Craik CS. PMID: 1988010.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    292. Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2. Proteins. 1991; 10(1):1-9. Tomasselli AG, Howe WJ, Hui JO, Sawyer TK, Reardon IM, DeCamp DL, Craik CS, Heinrikson RL. PMID: 2062825.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    293. A Primary Determinant for Lipoxygenase Postional Specificity. Nature 354, 149-152. 1991. D.L. Sloane, R. Leung, C.S. Craik & E. Sigal..
    294. Structure-based inhibition of HIV-1 protease activity and viral infectivity. Adv Exp Med Biol. 1991; 306:489-92. DeCamp DL, Babé LM, Furth P, Ortiz de Montellano P, Kuntz ID, Craik CS. PMID: 1812747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    295. Time dependent heterodimer formation leads to inhibition of HIV protease activity. Adv Exp Med Biol. 1991; 306:543-7. Babé LM, Craik CS. PMID: 1812756.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    296. Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:25-8. Sloane DL, Dixon RA, Craik CS, Sigal E. PMID: 1825549.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    297. 1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures. Proteins. 1991; 10(3):171-87. Earnest T, Fauman E, Craik CS, Stroud R. PMID: 1881877.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    298. Adv. Exptl. Med. Bio. Structure-based inhibition of HIV-1 protease activity and viral infectivity. 1991; 306:489-492 . D.L. DeCamp, L.M. Babé, P. Furth, P. Ortiz de Montellano, I.D. Kuntz & C.S. Craik..
    299. 1991; 353, 469 . C.S.Craik. Modus Operandi. Nature .
    300. Regulation of serine protease activity by an engineered metal switch. Biochemistry. 1990 Sep 18; 29(37):8582-6. Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS. PMID: 2125468.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    301. Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast. Biochem Biophys Res Commun. 1990 Sep 14; 171(2):589-95. Bathurst IC, Moen LK, Lujan MA, Gibson HL, Feucht PH, Pichuantes S, Craik CS, Santi DV, Barr PJ. PMID: 1698361.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    302. Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):6954-8. Hall MN, Craik C, Hiraoka Y. PMID: 1976249.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    303. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6644-8. DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babé LM, Craik CS. PMID: 2204060.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    304. Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro. J Biol Chem. 1990 Aug 15; 265(23):13890-8. Pichuantes S, Babé LM, Barr PJ, DeCamp DL, Craik CS. PMID: 2199446.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    305. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc Natl Acad Sci U S A. 1990 May; 87(10):3811-5. Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH. PMID: 2187193.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    306. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter. Am J Hum Genet. 1990 Apr; 46(4):795-800. Stewart EA, Craik CS, Hake L, Bowcock AM. PMID: 1969228.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    307. Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related. J Biol Chem. 1990 Mar 25; 265(9):5113-20. Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS. PMID: 2318885.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    308. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Mol Biochem Parasitol. 1990 Feb; 39(1):1-8. Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH. PMID: 2406590.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    309. 1990; 456-464 . A.L. Ferris, A. Hizi, S.D. Showalter, S. Pichuantes, L. Babé & C.S. Craik. Immunologic and Proteolytic Analysis of HIV-2 Reverse Transcriptase Structure. Virology 175..
    310. 1990. S. Pichuantes, L. Babé, P. Barr, D. DeCamp & C.S. Craik. Recombinant HIV 2 Protease Processes HIV 1 Pr53gag and Analogous Junction Peptides In Vitro. J. Bio. Chem. 265, 13890-13898 .
    311. 1990; 6659-6663. L. Evnin, J. Vasquez & C.S. Craik. Proc. Substrate Specificity of Trypsin Investigated Using a Genetic Selection. Natl. Acad. Sci. USA 87 ..
    312. 1990. M. Obukowicz, M. Gustafson, K. Junger, R. Leimgruber, A. Wittwer, T-C. Wun, T. Warren, B. Bishop, K. Mathis, D. McPherson, N. Siegel, M. Jennings, B. Brightwell, J. Diaz-Collier, L. Bell, C.S. Craik & W. Tacon. Secretion of Active Kringle 2-Serine Protease in E. coli. J. Bio. Chem. 29, 9737-9745 .
    313. 1990. E. Stewart, C.S. Craik, L. Hake & A. Bowcock. Human CPA Identifies a BglII RFLP and Maps to 7q31-qter. Amer. J. Hum. Gen. 46, 795 -800 .
    314. The expression of active human reticulocyte 15-lipoxygenase in bacteria. Biomed Biochim Acta. 1990; 49(2-3):S11-6. Sloane DL, Craik CS, Sigal E. PMID: 1696810.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    315. Crystal structures of two engineered thiol trypsins. Biochemistry. 1989 Nov 28; 28(24):9264-70. McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ. PMID: 2611228.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    316. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4863-7. Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH. PMID: 2662185.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    317. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 1989 May 16; 28(10):4148-55. Vanderslice P, Craik CS, Nadel JA, Caughey GH. PMID: 2504277.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    318. Rapid preparation of proteins for crystallization trials. Biotechniques. 1989 Mar; 7(3):246-7. McGrath ME, Fletterick RJ, Craik CS. PMID: 2631770.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    319. An expression system for trypsin. J Cell Biochem. 1989 Mar; 39(3):265-76. Vasquez JR, Evnin LB, Higaki JN, Craik CS. PMID: 2651464.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    320. [A case of aseptic meningoencephalitis with recurrent abnormal behavior, status epilepticus and aphthous stomatitis, improved by acyclovir]. Rinsho Shinkeigaku. 1989 Mar; 29(3):367-70. Shimada K, Koh CS, Hashimoto T, Shoji S, Yanagisawa N. PMID: 2752665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    321. Cloning and expression of human arachidonate 15-lipoxygenase. Trans Assoc Am Physicians. 1989; 102:176-84. Sigal E, Craik CS, Dixon RA, Nadel JA. PMID: 2638524.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    322. Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:156-9. Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA. PMID: 2526462.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    323. Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein. Proteins. 1989; 6(3):324-37. Pichuantes S, Babé LM, Barr PJ, Craik CS. PMID: 2695931.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    324. 1989. A. Eakin, J.N. Higaki, J.H. McKerrow & C.S. Craik. Cysteine or Serine Proteinase. Nature 342, 132.
    325. 1989. J. Higaki L.B. Evnin & C.S. Craik. Introduction of a Cysteine Protease Active Site into Trypsin. Biochem. 28, 9256-9263 .
    326. Molecular cloning and primary structure of human 15-lipoxygenase. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):457-64. Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA. PMID: 3202857.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    327. Structural and functional integrity of specificity and catalytic sites of trypsin. Int J Pept Protein Res. 1988 Dec; 32(6):512-8. Gráf L, Hegyi G, Likó I, Hepp J, Medzihradszky K, Craik CS, Rutter WJ. PMID: 2907752.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    328. A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family. J Biol Chem. 1988 Nov 25; 263(33):17828-36. Gardell SJ, Craik CS, Clauser E, Goldsmith EJ, Stewart CB, Graf M, Rutter WJ. PMID: 3182871.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    329. Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family. J Biol Chem. 1988 Nov 25; 263(33):17837-45. Clauser E, Gardell SJ, Craik CS, MacDonald RJ, Rutter WJ. PMID: 3182872.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    330. Efficient targeting to storage granules of human proinsulins with altered propeptide domain. J Cell Biol. 1988 Jun; 106(6):1843-51. Powell SK, Orci L, Craik CS, Moore HP. PMID: 2838491.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    331. Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases. J Biol Chem. 1988 Apr 15; 263(11):5328-32. Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA. PMID: 3356688.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    332. Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties. Biochem Biophys Res Commun. 1988 Jan 15; 150(1):376-83. Sigal E, Grunberger D, Cashman JR, Craik CS, Caughey GH, Nadel JA. PMID: 3337718.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    333. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants. Crit Rev Biotechnol. 1988; 8(3):225-36. Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS. PMID: 3063392.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    334. Development of an efficient method for generating and screening active trypsin and trypsin variants. Ann N Y Acad Sci. 1988; 542:61-74. Evnin LB, Craik CS. PMID: 3228244.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    335. The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science. 1987 Aug 21; 237(4817):905-9. Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. PMID: 3112942.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    336. The catalytic role of the active site aspartic acid in serine proteases. Science. 1987 Aug 21; 237(4817):909-13. Craik CS, Roczniak S, Largman C, Rutter WJ. PMID: 3303334.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    337. Isolation and characterization of a cDNA encoding rat cationic trypsinogen. Biochemistry. 1987 Jun 02; 26(11):3081-6. Fletcher TS, Alhadeff M, Craik CS, Largman C. PMID: 3607011.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    338. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry. 1987 May 05; 26(9):2616-23. Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ. PMID: 3111531.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    339. Redesigning trypsin via genetic engineering. J Cell Biochem. 1987 Mar; 33(3):199-211. Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. PMID: 3553217.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    340. Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A. 1987 Feb; 84(3):704-8. Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ. PMID: 3101064.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    341. 1987. C.S. Craik. Edited by D. Oxender. New York: Alan R. Liss, Inc. Expression and Overproduction of Proteins. In: Protein Structure, Folding and Design 2, pp. 467-476.
    342. 1987. T.L. Burgess, C.S. Craik, L. Matsuuchi & R.B. Kelly. In Vitro Mutagenesis of Trypsinogen: The Role of the N-Terminus in Intracellular Protein Targeting to Secretory Granules. J. Cell Bio. 105, 659-668 .
    343. 1987; 183-195. C.S. Craik, S. Roczniak, S. Sprang, R.J. Fletterick & W.J. Rutter. Edited by D. Cunningham and G. Long. New York: Alan R Liss, Inc. Redesigning Trypsin via Genetic Engineering. In: Proteases in Biological Control and Biotechnology.
    344. 1987. W.J. Rutter, S.J. Gardell, S. Roczniak, D. Hilvert, S. Sprang, R.J. Fletterick & C.S. Craik. Edited by D. Oxender and C.F. Fox. New York: Alan R. Liss, Inc. Redesigning Proteins via Genetic Engineering. In: Protein Modification and Design, pp. 257-267.
    345. Evolution of catalysis in the serine proteases. Cold Spring Harb Symp Quant Biol. 1987; 52:615-21. Higaki JN, Gibson BW, Craik CS. PMID: 3331347.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    346. Genetic analysis of cystic fibrosis: linkage of DNA and classical markers in multiplex families. Am J Hum Genet. 1986 Dec; 39(6):699-706. Bowcock AM, Crandall J, Daneshvar L, Lee GM, Young B, Zunzunegui V, Craik C, Cavalli-Sforza LL, King MC. PMID: 3026172.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    347. 1986. S. Gardell, C.S. Craik, D. Hilvert, M. Urdea & W. Rutter. Edited by I. Bertini, C. Luchinat, W. Maret, and M. Zeppezauer. Boston, Massachusetts: Birkhäuser. Probing the Role of Tyrosine 248 in Carboxypeptidase A with Site-Directed Mutagenesis. In: Comparative Analysis of Catalytic Mechanisms of Zinc Enzymes.
    348. Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis. Nature. 1985 Oct 10-16; 317(6037):551-5. Gardell SJ, Craik CS, Hilvert D, Urdea MS, Rutter WJ. PMID: 3840231.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    349. The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer. J Cell Biol. 1985 Aug; 101(2):639-45. Burgess TL, Craik CS, Kelly RB. PMID: 2991303.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    350. Redesigning trypsin: alteration of substrate specificity. Science. 1985 Apr 19; 228(4697):291-7. Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. PMID: 3838593.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    351. Biotechniques. Use of Oligonucleotides for Site-Specific Mutagenesis. 1985; 3:12-19. C.S. Craik..
    352. Structure of the two related elastase genes expressed in the rat pancreas. J Biol Chem. 1984 Nov 25; 259(22):14271-8. Swift GH, Craik CS, Stary SJ, Quinto C, Lahaie RG, Rutter WJ, MacDonald RJ. PMID: 6094548.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    353. Structure of two related rat pancreatic trypsin genes. J Biol Chem. 1984 Nov 25; 259(22):14255-64. Craik CS, Choo QL, Swift GH, Quinto C, MacDonald RJ, Rutter WJ. PMID: 6094547.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    354. Isolation and sequence of a rat chymotrypsin B gene. J Biol Chem. 1984 Nov 25; 259(22):14265-70. Bell GI, Quinto C, Quiroga M, Valenzuela P, Craik CS, Rutter WJ. PMID: 6209274.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    355. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul; 10(4):377-83. Honey NK, Sakaguchi AY, Lalley PA, Quinto C, MacDonald RJ, Craik C, Bell GI, Rutter WJ, Naylor SL. PMID: 6589791.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    356. Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase. Somat Cell Mol Genet. 1984 Jul; 10(4):369-76. Honey NK, Sakaguchi AY, Quinto C, MacDonald RJ, Bell GI, Craik C, Rutter WJ, Naylor SL. PMID: 6589790.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    357. Splice junctions: association with variation in protein structure. Science. 1983 Jun 10; 220(4602):1125-9. Craik CS, Rutter WJ, Fletterick R. PMID: 6344214.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    358. Intron-exon splice junctions map at protein surfaces. Nature. 1982 Sep 09; 299(5879):180-2. Craik CS, Sprang S, Fletterick R, Rutter WJ. PMID: 7110339.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    359. 1982; 192-197. C.S. Craik & S. Beychok. Edited by C. Ho. In: Interaction Between Iron Proteins in Oxygen and Electron Transport, Elsevier North Holland Biomedical Press .
    360. O2 binding properties of the product of the central exon of beta-globin gene. Nature. 1981 May 07; 291(5810):87-90. Craik CS, Buchman SR, Beychok S. PMID: 7231528.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    361. Refolding defects in hemoglobin Rothschild. J Biol Chem. 1980 Jul 10; 255(13):6219-23. Craik CS, Vallette I, Beychok S, Waks M. PMID: 7391018.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    362. Characterization of globin domains: heme binding to the central exon product. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1384-8. Craik CS, Buchman SR, Beychok S. PMID: 6929492.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    Charles's Networks
    Concepts (1037)
    Derived automatically from this person's publications.
    _
    Co-Authors (147)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _