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Maxence Nachury, PhD

Photo of Maxence Nachury, PhD
Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #352X
San Francisco CA 94158
ORCID ORCID Icon0000-0003-4918-1562 Additional info
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    Collapse Biography 
    Collapse education and training
    UC Berkeley, BerkeleyPhD12/2001Molecular and Cellular Biology
    Stanford and Genentech, Stanford and South San FranciscoPostodoctorate12/2007Cell Biology and Biochemistry
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse awards and honors
    Kinship Foundation2010Searle Scholar
    American Society for Cell Biology2011Early Career Life Scientist Award
    American Society for Cell Biology2016Keith R. Porter Fellowship Award
    Association for Research in Vision and Ophthalmology2019Cogan Award

    Collapse Overview 
    Collapse overview
    We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling. Our lab is interested in the mechanisms of trafficking in and out of cilia and how trafficking decisions impact signaling at the cilium. One research axis focuses on Bardet-Biedl Syndrome (BBS), a ciliopathy characterized by obesity, skeletal malformations and kidney cysts. The BBSome is an evolutionarily conserved complex of 8 BBS proteins that traffics signaling receptors out of cilia and we aim to decipher the molecular details of BBSome-mediated trafficking and the cellular, biochemical and structural level. A second research direction is aimed at cilia-derived extracellular vesicles (EVs). Ciliary signaling receptors that fail conventional exit are packaged into ciliary EVs. By dissecting the mechanisms of ciliary EV biogenesis, we will gain insight into the roles of these extracellular parcels in cell-cell communication.
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    Collapse Research 
    Collapse research activities and funding
    Structural basis of BBSome-mediated ciliary exit
    NIH R01EY031462Jun 1, 2020 - May 31, 2024
    Role: Principal Investigator
    Proteomics of Primary Cilia through Proximity Labeling
    NIH R21HD087126Dec 1, 2015 - Nov 30, 2019
    Role: Principal Investigator
    Quality control of the primary cilium proteome
    NIH R01GM089933Apr 1, 2010 - Jan 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MON-661 Melanocortin-4 Receptor is Rapidly Ubiquitinated, Exits Primary Cilia and Undergoes Endocytosis After Activation. Journal of the Endocrine Society. 2025 Oct 22; 9(Supplement_1):bvaf149.001. Diamant DA, Ojeda-Naharros OI, Vaisse VC, Nachury NM. .
      View in: Publisher Site   Mentions:
    2. BBSome-Mediated Clearance of Ubiquitinated IMPG2 Defines a Constitutive Ciliary Retrieval Pathway in Photoreceptors. bioRxiv. 2025 Aug 01. Das T, Bradshaw GA, Hyer J, Masek M, Kuo YM, Bachmann-Gagescu R, Kalocsay M, Nachury MV. PMID: 40766594; PMCID: PMC12324355.
      View in: PubMed   Mentions:
    3. Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2413968122. Sun S, Liang B, Koplas A, Tikhonenko I, Nachury M, Khodjakov A, Sui H. PMID: 40249775; PMCID: PMC12037007.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia. PLoS Biol. 2025 Feb; 23(2):e3003025. Ojeda-Naharros I, Das T, Castro RA, Bazan JF, Vaisse C, Nachury MV. PMID: 39899600; PMCID: PMC11825094.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Long-term effectiveness and acceptability of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel disease treated with intensified doses: The REMSWITCH-LT study. Aliment Pharmacol Ther. 2024 02; 59(4):526-534. Buisson A, Nachury M, Bazoge M, Yzet C, Wils P, Dodel M, Coban D, Pereira B, Fumery M. PMID: 38037279.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    6. Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling. Cell Rep. 2023 10 31; 42(10):113272. Hoi KK, Xia W, Wei MM, Ulloa Navas MJ, Garcia Verdugo JM, Nachury MV, Reiter JF, Fancy SPJ. PMID: 37858465; PMCID: PMC10715572.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia. Dev Cell. 2023 04 24; 58(8):677-693.e9. Shinde SR, Mick DU, Aoki E, Rodrigues RB, Gygi SP, Nachury MV. PMID: 37019113; PMCID: PMC10133032.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    8. MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R. JCI Insight. 2023 01 24; 8(2). Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C. PMID: 36692018; PMCID: PMC9977312.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    9. The gymnastics of intraflagellar transport complexes keeps trains running inside cilia. Cell. 2022 12 22; 185(26):4863-4865. Nachury MV. PMID: 36563659.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    10. Shedding of ciliary vesicles at a glance. J Cell Sci. 2022 10 01; 135(19). Ojeda Naharros I, Nachury MV. PMID: 36222105; PMCID: PMC10399986.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    11. Localization of GFP-Tagged Proteins Under the Electron Microscope. . 2021 Jul 27; 169:201-212. Gil-Perotin GS, Cebrián-Silla CA, Herranz-Pérez HV, García-Belda GP, Gil-García GS, Fil FM, Lee LJ, Nachury NM, García-Verdugo GJ. .
      View in: Publisher Site   Mentions:
    12. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol. 2021 05 03; 220(5). May EA, Kalocsay M, D'Auriac IG, Schuster PS, Gygi SP, Nachury MV, Mick DU. PMID: 33856408; PMCID: PMC8054476.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    13. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia. J Cell Biol. 2020 12 07; 219(12). Shinde SR, Nager AR, Nachury MV. PMID: 33185668; PMCID: PMC7716378.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    14. Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes. Elife. 2020 06 08; 9. Yang S, Bahl K, Chou HT, Woodsmith J, Stelzl U, Walz T, Nachury MV. PMID: 32510327; PMCID: PMC7311171.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    15. The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach. Structure. 2019 09 03; 27(9):1384-1394.e4. Chou HT, Apelt L, Farrell DP, White SR, Woodsmith J, Svetlov V, Goldstein JS, Nager AR, Li Z, Muller J, Dollfus H, Nudler E, Stelzl U, DiMaio F, Nachury MV, Walz T. PMID: 31303482; PMCID: PMC6726506.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    16. Establishing and regulating the composition of cilia for signal transduction. Nat Rev Mol Cell Biol. 2019 07; 20(7):389-405. Nachury MV, Mick DU. PMID: 30948801; PMCID: PMC6738346.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    17. Effects of α-tubulin acetylation on microtubule structure and stability. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10366-10371. Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E. PMID: 31072936; PMCID: PMC6535015.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    18. Adalimumab for patients with Crohn's disease complicated by intra-abdominal abscess: a multicentre, prospective, observational cohort study. J Crohns Colitis. 2019 Jan 25; 13(Supplement_1):S616. Pineton de Chambrun G, Pariente B, Seksik P, Altwegg R, Vuitton L, Stefasnescu C, Nancey S, Aubourg A, Serrero M, Peyrin-Biroulet L, Filippi J, Viennot S, Abitbol V, Boualit M, Boureille A, Moreau J, Buisson A, Roblin X, Nachury M, Zappa M, Lambert J, Bouhnik Y, GETAID-MICA study group. PMID: 30794285.
      View in: PubMed   Mentions: 3     Fields:    
    19. The molecular machines that traffic signaling receptors into and out of cilia. Curr Opin Cell Biol. 2018 04; 51:124-131. Nachury MV. PMID: 29579578; PMCID: PMC5949257.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    20. BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone. J Cell Biol. 2018 05 07; 217(5):1847-1868. Ye F, Nager AR, Nachury MV. PMID: 29483145; PMCID: PMC5940304.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    21. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nat Genet. 2018 03; 50(3):460-471. Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV. PMID: 29459677; PMCID: PMC5862771.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    22. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Curr Biol. 2017 Sep 11; 27(17):2569-2578.e4. Niwa S, Tao L, Lu SY, Liew GM, Feng W, Nachury MV, Shen K. PMID: 28823680; PMCID: PMC5693321.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    23. Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents. Am J Gastroenterol. 2018 02; 113(2):265-272. Ghione S, Sarter H, Fumery M, Armengol-Debeir L, Savoye G, Ley D, Spyckerelle C, Pariente B, Peyrin-Biroulet L, Turck D, Gower-Rousseau C, Andre JM, Antonietti M, Aouakli A, Armand A, Aroichane I, Assi F, Aubet JP, Auxenfants E, Ayafi-Ramelot F, Bankovski D, Barbry B, Bardoux N, Baron P, Baudet A, Bazin B, Bebahani A, Becqwort JP, Benet V, Benali H, Benguigui C, Soussan BE, Bental A, Berkelmans I, Bernet J, Bernou K, Bernou-Dron C, Bertot P, Bertiaux-Vandaële N, Bertrand V, Billoud E, Biron N, Bismuth B, Bleuet M, Blondel F, Blondin V, Bohon P, Boniface E, Bonnière P, Bonvarlet E, Bonvarlet P, Boruchowicz A, Bostvironnois R, Boualit M, Bouche B, Boudaillez C, Bourgeaux C, Bourgeois M, Bourguet A, Bourienne A, Branche J, Bray G, Brazier F, Breban P, Brihier H, Brung-Lefebvre V, Bulois P, Burgiere P, Butel J, Canva JY, Canva-Delcambre V, Capron JP, Cardot F, Carpentier P, Cartier E, Cassar JF, Cassagnou M, Castex JF, Catala P, Cattan S, Catteau S, Caujolle B, Cayron G, Chandelier C, Chantre M, Charles J, Charneau T, Chavance-Thelu M, Chirita D, Choteau A, Claerbout JF, Clergue PY, Coevoet H, Cohen G, Collet R, Colombel JF, Coopman S, Corvisart J, Cortot A, Couttenier F, Crinquette JF, Crombe V, Dadamessi I, Dapvril V, Davion T, Dautreme S, Debas J, Degrave N, Dehont F, Delatre C, Delcenserie R, Delette O, Delgrange T, Delhoustal L, Delmotte JS, Demmane S, Deregnaucourt G, Descombes P, Desechalliers JP, Desmet P, Desreumaux P, Desseaux G, Desurmont P, Devienne A, Devouge E, Devred M, Devroux A, Dewailly A, Dharancy S, Di Fiore A, Djeddi D, Djedir R, Dreher-Duwat ML, Dubois R, Dubuque C, Ducatillon P, Duclay J, Ducrocq B, Ducrot F, Ducrotte P, Dufilho A, Duhamel C, Dujardin D, Dumant-Forest C, Dupas JL, Dupont F, Duranton Y, Duriez A, El Achkar K, El Farisi M, Elie C, Elie-Legrand MC, Elkhaki A, Eoche M, Evrard D, Evrard JP, Fatome A, Filoche B, Finet L, Flahaut M, Flamme C, Foissey D, Fournier P, Foutrein-Comes MC, Foutrein P, Fremond D, Frere T, Fumery M, Gallet P, Gamblin C, Ganga-Zandzou PS, Gérard R, Geslin G, Gheyssens Y, Ghossini N, Ghrib S, Gilbert T, Gillet B, Godard D, Godard P, Godchaux JM, Godchaux R, Goegebeur G, Goria O, Gottrand F, Gower P, Grandmaison B, Groux M, Guedon C, Guillard JF, Guillem L, Guillemot F, Guimber D, Haddouche B, Hakim S, Hanon D, Hautefeuille V, Heckestweiller P, Hecquet G, Hedde JP, Hellal H, Henneresse PE, Heyman B, Heraud M, Herve S, Hochain P, Houssin-Bailly L, Houcke P, Huguenin B, Iobagiu S, Ivanovic A, Iwanicki-Caron I, Janicki E, Jarry M, Jeu J, Joly JP, Jonas C, Katherin F, Kerleveo A, Khachfe A, Kiriakos A, Kiriakos J, Klein O, Kohut M, Kornhauser R, Koutsomanis D, Laberenne JE, Laffineur G, Lagarde M, Lannoy P, Lapchin J, Lapprand M, Laude D, Leblanc R, Lecieux P, Leclerc N, Le Couteulx C, Ledent J, Lefebvre J, Lefiliatre P, Legrand C, Le Grix A, Lelong P, Leluyer B, Lenaerts C, Lepileur L, Leplat A, Lepoutre-Dujardin E, Leroi H, Leroy MY, Lesage JP, Lesage X, Lesage J, Lescanne-Darchis I, Lescut J, Lescut D, Leurent B, Levy P, Lhermie M, Lion A, Lisambert B, Loire F, Louf S, Louvet A, Luciani M, Lucidarme D, Lugand J, Macaigne O, Maetz D, Maillard D, Mancheron H, Manolache O, Marks-Brunel AB, Marti R, Martin F, Martin G, Marzloff E, Mathurin P, Mauillon J, Maunoury V, Maupas JL, Mesnard B, Metayer P, Methari L, Meurisse B, Meurisse F, Michaud L, Mirmaran X, Modaine P, Monthe A, Morel L, Mortier PE, Moulin E, Mouterde O, Mudry J, Nachury M, Khac NE, Notteghem B, Ollevier V, Ostyn A, Ouraghi A, Ouvry D, Paillot B, Panien-Claudot N, Paoletti C, Papazian A, Parent B, Pariente B, Paris JC, Patrier P, Paupart L, Pauwels B, Pauwels M, Petit R, Piat M, Piotte S, Plane C, Plouvier B, Pollet E, Pommelet P, Pop D, Pordes C, Pouchain G, Prades P, Prevost A, Prevost JC, Quesnel B, Queuniet AM, Quinton JF, Rabache A, Rabelle P, Raclot G, Ratajczyk S, Rault D, Razemon V, Reix N, Revillon M, Richez C, Robinson P, Rodriguez J, Roger J, Roux JM, Rudelli A, Saber A, Savoye G, et al. PMID: 28809388.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    24. Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife. 2017 05 19; 6. Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. PMID: 28524820; PMCID: PMC5478271.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. Microtubules acquire resistance from mechanical breakage through intralumenal acetylation. Science. 2017 04 21; 356(6335):328-332. Xu Z, Schaedel L, Portran D, Aguilar A, Gaillard J, Marinkovich MP, Théry M, Nachury MV. PMID: 28428427; PMCID: PMC5457157.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansCells
    26. Membrane traffic control by cytoskeletal and molecular machines. Mol Biol Cell. 2017 03 15; 28(6):697-698. Lee TH, Nachury MV. PMID: 28292910; PMCID: PMC5349772.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. J Med Genet. 2017 06; 54(6):371-380. Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-Pérez V, Goldstein JS, Pasquier L, Loget P, Saunier S, Mégarbané A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C. PMID: 28289185; PMCID: PMC5557276.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    28. Measurement of tubulin oligomers self-assembly by FRET. Protocol Exchange. 2017 Mar 9. Portran PD, Portran PD, Nachury NM. .
      View in: Publisher Site   Mentions:
    29. Tubulin acetylation protects long-lived microtubules against mechanical ageing. Nat Cell Biol. 2017 04; 19(4):391-398. Portran D, Schaedel L, Xu Z, Théry M, Nachury MV. PMID: 28250419; PMCID: PMC5376231.
      View in: PubMed   Mentions: 245     Fields:    Translation:AnimalsCells
    30. An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling. Cell. 2017 Jan 12; 168(1-2):252-263.e14. Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury MV. PMID: 28017328; PMCID: PMC5235987.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansAnimalsCells
    31. Endoscopic Detection of Small Bowel Dysplasia and Adenocarcinoma in Crohn's Disease: A Prospective Cohort-Study in High-Risk Patients. J Crohns Colitis. 2017 Jan; 11(1):47-52. Simon M, Cosnes J, Gornet JM, Seksik P, Stefanescu C, Blain A, Pariente B, Nancey S, Vuitton L, Nachury M, D'Haens G, Filippi J, Chevret S, Laharie D, GETAID group. PMID: 27405958.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    32. Ileal or Anastomotic Location of Lesions Does Not Impact Rate of Postoperative Recurrence in Crohn's Disease Patients Classified i2 on the Rutgeerts Score. Dig Dis Sci. 2016 10; 61(10):2986-2992. Bayart P, Duveau N, Nachury M, Zerbib P, Gerard R, Branche J, Maunoury V, Wils P, Boruchowicz A, Boualit M, Laberenne JE, Manolache O, Desreumaux P, de Chambrun GP, Pariente B. PMID: 27401274.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    33. Localization of GFP-Tagged Proteins at the Electron Microscope. Receptor and Ion Channel Detection in the Brain. 2016 Jan 1; 110:179-190. Gil-Perotin GS, Cebrián-Silla CA, Herranz-Pérez HV, García-Belda GP, Gil-García GS, Fil FM, Lee LJ, Nachury NM, García-Verdugo GJ. .
      View in: Publisher Site   Mentions:
    34. Abstract B068: Structural basis for Notch1 engagement of Delta-like 4 and Jagged1. Immune Regulation of T Cell Responses/ Evolving Concepts in Cancer Immunology. 2016 Jan 1; b068-b068. Luca LV, Jude JK, Pierce PN, Nachury NM, Fischer FS, Garcia GK. .
      View in: Publisher Site   Mentions:
    35. Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):632-7. Langousis G, Shimogawa MM, Saada EA, Vashisht AA, Spreafico R, Nager AR, Barshop WD, Nachury MV, Wohlschlegel JA, Hill KL. PMID: 26721397; PMCID: PMC4725476.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    36. The Intraflagellar Transport Protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Cilia. 2015 Dec 1; 4(Suppl 1):o18. Liew LG, Ye YF, Nager NA, Murphy MJ, Lee LJ, Aguiar AM, Breslow BD, Gygi GS, Nachury NM. .
      View in: Publisher Site   Mentions:
    37. Proteomics of Primary Cilia by Proximity Labeling. Dev Cell. 2015 Nov 23; 35(4):497-512. Mick DU, Rodrigues RB, Leib RD, Adams CM, Chien AS, Gygi SP, Nachury MV. PMID: 26585297; PMCID: PMC4662609.
      View in: PubMed   Mentions: 236     Fields:    Translation:AnimalsCells
    38. Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. ACS Chem Biol. 2016 Jan 15; 11(1):53-60. See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK. PMID: 26555042; PMCID: PMC4715766.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Microtubules self-repair in response to mechanical stress. Nat Mater. 2015 Nov; 14(11):1156-63. Schaedel L, John K, Gaillard J, Nachury MV, Blanchoin L, Théry M. PMID: 26343914; PMCID: PMC4620915.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    40. Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science. 2015 Feb 20; 347(6224):847-53. Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. PMID: 25700513; PMCID: PMC4445638.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    41. Analysis of soluble protein entry into primary cilia using semipermeabilized cells. Methods Cell Biol. 2015; 127:203-21. Breslow DK, Nachury MV. PMID: 25837393; PMCID: PMC4797650.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. Structural basis for membrane targeting of the BBSome by ARL6. Nat Struct Mol Biol. 2014 Dec; 21(12):1035-41. Mourão A, Nager AR, Nachury MV, Lorentzen E. PMID: 25402481; PMCID: PMC4255524.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    43. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev Cell. 2014 Nov 10; 31(3):265-278. Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV. PMID: 25443296; PMCID: PMC4255629.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    44. How do cilia organize signalling cascades? Philos Trans R Soc Lond B Biol Sci. 2014 Sep 05; 369(1650). Nachury MV. PMID: 25047619; PMCID: PMC4113109.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    45. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nat Genet. 2014 Aug; 46(8):905-11. Thauvin-Robinet C, Lee JS, Lopez E, Herranz-Pérez V, Shida T, Franco B, Jego L, Ye F, Pasquier L, Loget P, Gigot N, Aral B, Lopes CA, St-Onge J, Bruel AL, Thevenon J, González-Granero S, Alby C, Munnich A, Vekemans M, Huet F, Fry AM, Saunier S, Rivière JB, Attié-Bitach T, Garcia-Verdugo JM, Faivre L, Mégarbané A, Nachury MV. PMID: 24997988; PMCID: PMC4120243.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    46. Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol Biol Cell. 2014 Jun 15; 25(12):1854-66. Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV. PMID: 24743598; PMCID: PMC4055265.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    47. Movement of Signaling Receptors Inside Primary Cilia. Biophysical Journal. 2014 Jan 1; 106(2):9a. Nachury NM. .
      View in: Publisher Site   Mentions:
    48. Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure. Mol Biol Cell. 2014 Jan; 25(2):257-66. Howes SC, Alushin GM, Shida T, Nachury MV, Nogales E. PMID: 24227885; PMCID: PMC3890346.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    49. Cilia grow by taking a bite out of the cell. Dev Cell. 2013 Oct 28; 27(2):126-127. Pierce NW, Nachury MV. PMID: 24176638; PMCID: PMC3890250.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    50. An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. J Cell Biol. 2013 Oct 14; 203(1):129-47. Breslow DK, Koslover EF, Seydel F, Spakowitz AJ, Nachury MV. PMID: 24100294; PMCID: PMC3798247.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    51. αTAT1 catalyses microtubule acetylation at clathrin-coated pits. Nature. 2013 Oct 24; 502(7472):567-70. Montagnac G, Meas-Yedid V, Irondelle M, Castro-Castro A, Franco M, Shida T, Nachury MV, Benmerah A, Olivo-Marin JC, Chavrier P. PMID: 24097348; PMCID: PMC3970258.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    52. Exome sequencing of Bardet-Biedl syndrome patient identifies a null mutation in the BBSome subunit BBIP1 (BBS18). J Med Genet. 2014 Feb; 51(2):132-6. Scheidecker S, Etard C, Pierce NW, Geoffroy V, Schaefer E, Muller J, Chennen K, Flori E, Pelletier V, Poch O, Marion V, Stoetzel C, Strähle U, Nachury MV, Dollfus H. PMID: 24026985; PMCID: PMC3966300.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    53. Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors. Elife. 2013 Aug 06; 2:e00654. Ye F, Breslow DK, Koslover EF, Spakowitz AJ, Nelson WJ, Nachury MV. PMID: 23930224; PMCID: PMC3736543.
      View in: PubMed   Mentions: 85     Fields:    Translation:Cells
    54. Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19655-60. Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R. PMID: 23071314; PMCID: PMC3511727.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    55. A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genet. 2011 Nov; 7(11):e1002358. Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, Sheffield VC. PMID: 22072986; PMCID: PMC3207910.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    56. Give chance a chance. Mol Biol Cell. 2011 Nov; 22(21):3919-20. Nachury MV. PMID: 22039061; PMCID: PMC3204048.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    57. Primary cilia: how to keep the riff-raff in the plasma membrane. Curr Biol. 2011 Jun 07; 21(11):R434-6. Breslow DK, Nachury MV. PMID: 21640903.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    58. Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2759-64. Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK. PMID: 21273506; PMCID: PMC3041065.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    59. The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21517-22. Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV. PMID: 21068373; PMCID: PMC3003046.
      View in: PubMed   Mentions: 254     Fields:    Translation:AnimalsCells
    60. Maxence Nachury: a transporting view of the primary cilium. Interview by Ben Short. J Cell Biol. 2010 Nov 01; 191(3):436-7. Nachury M. PMID: 21041439; PMCID: PMC3003325.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    61. The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell. 2010 Jun 25; 141(7):1208-19. Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury MV. PMID: 20603001; PMCID: PMC2898735.
      View in: PubMed   Mentions: 384     Fields:    Translation:HumansAnimalsCells
    62. A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science. 2010 Jul 23; 329(5990):436-9. Hu Q, Milenkovic L, Jin H, Scott MP, Nachury MV, Spiliotis ET, Nelson WJ. PMID: 20558667; PMCID: PMC3092790.
      View in: PubMed   Mentions: 296     Fields:    Translation:AnimalsCells
    63. The perennial organelle: assembly and disassembly of the primary cilium. J Cell Sci. 2010 Feb 15; 123(Pt 4):511-8. Seeley ES, Nachury MV. PMID: 20144999; PMCID: PMC2818191.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    64. Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Annu Rev Cell Dev Biol. 2010; 26:59-87. Nachury MV, Seeley ES, Jin H. PMID: 19575670; PMCID: PMC2952038.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimalsCells
    65. Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer. Methods Cell Biol. 2009; 94:299-313. Seeley ES, Nachury MV. PMID: 20362097; PMCID: PMC2885964.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    66. The BBSome. Curr Biol. 2009 Jun 23; 19(12):R472-3. Jin H, Nachury MV. PMID: 19549489.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    67. A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Dev Cell. 2008 Dec; 15(6):854-65. Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV. PMID: 19081074.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    68. How to build a signalling organelle: A molecular pathway for biogenesis of the ciliary membrane. The FASEB Journal. 2008 Mar 1; 22:628.1-628.1. Nachury NM. .
      View in: Publisher Site   Mentions:
    69. The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle. 2008 May 01; 7(9):1184-90. Berdougo E, Nachury MV, Jackson PK, Jallepalli PV. PMID: 18418058.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    70. Tandem affinity purification of the BBSome, a critical regulator of Rab8 in ciliogenesis. Methods Enzymol. 2008; 439:501-13. Nachury MV. PMID: 18374185.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    71. [Cronkhite-Canada syndrome]. Ann Dermatol Venereol. 2007 Aug-Sep; 134(8-9):709-10. Duong T, Marrache F, Nachury M, Dubertret L, Lémann M, Viguier M. PMID: 17925707.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    72. The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev Cell. 2007 Jul; 13(1):29-42. Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK. PMID: 17609108.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    73. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell. 2007 Jun 15; 129(6):1201-13. Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK. PMID: 17574030.
      View in: PubMed   Mentions: 838     Fields:    Translation:HumansAnimalsCells
    74. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 2006 Sep 01; 20(17):2410-20. Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. PMID: 16921029; PMCID: PMC1560415.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    75. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell. 2005 Apr 22; 121(2):223-34. Blower MD, Nachury M, Heald R, Weis K. PMID: 15851029.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    76. Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. BMC Cell Biol. 2004 Jul 13; 5:27. Kaiser BK, Nachury MV, Gardner BE, Jackson PK. PMID: 15251038; PMCID: PMC481057.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    77. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell. 2001 Jan 12; 104(1):95-106. Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K. PMID: 11163243.
      View in: PubMed   Mentions: 175     Fields:    Translation:AnimalsCells
    78. The direction of transport through the nuclear pore can be inverted. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9622-7. Nachury MV, Weis K. PMID: 10449743; PMCID: PMC22259.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    79. Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):582-7. Nachury MV, Ryder UW, Lamond AI, Weis K. PMID: 9435235; PMCID: PMC18463.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
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