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Maxence Nachury, PhD

TitleAdjunct Instructor
SchoolUCSF School of Medicine
DepartmentOphthalmology
Address10 Koret Way
San Francisco CA 94117
Phone415-476-6758
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    Collapse Biography 
    Collapse Education and Training
    UC Berkeley, BerkeleyPhD12/2001Molecular and Cellular Biology
    Collapse Awards and Honors
    Kinship Foundation2010Searle Scholar
    American Society for Cell Biology2011Early Career Life Scientist Award
    American Society for Cell Biology2016Keith R. Porter Fellowship Award

    Collapse Overview 
    Collapse Overview
    We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling and whose dysfunction leads to obesity, skeletal malformations and kidney cysts. To decode the fundamental principles of ciliary trafficking and to understand how trafficking shapes signaling at the primary cilium, we leverage a broad expertise in biochemistry, proteomics, cell biology and in vitro reconstitution


    Collapse Research 
    Collapse Research Activities and Funding
    Proteomics of Primary Cilia through Proximity Labeling
    NIH/NICHD R21HD087126Dec 1, 2015 - Nov 30, 2017
    Role: Principal Investigator
    MOLECULAR STUDIES OF PRIMARY CILIUM BIOGENESIS
    NIH/NIGMS R01GM089933Apr 1, 2010 - Jan 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Niwa S, Tao L, Lu SY, Liew GM, Feng W, Nachury M, Shen K. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Curr Biol. 2017 Aug 10. PMID: 28823680.
      View in: PubMed
    2. Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury M, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife. 2017 May 19; 6. PMID: 28524820.
      View in: PubMed
    3. Xu Z, Schaedel L, Portran D, Aguilar A, Gaillard J, Marinkovich MP, Théry M, Nachury M. Microtubules acquire resistance from mechanical breakage through intralumenal acetylation. Science. 2017 Apr 21; 356(6335):328-332. PMID: 28428427.
      View in: PubMed
    4. Lee TH, Nachury M. Membrane traffic control by cytoskeletal and molecular machines. Mol Biol Cell. 2017 Mar 15; 28(6):697-698. PMID: 28292910.
      View in: PubMed
    5. Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-Pérez V, Goldstein JS, Pasquier L, Loget P, Saunier S, Mégarbané A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury M, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C. Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. J Med Genet. 2017 Jun; 54(6):371-380. PMID: 28289185.
      View in: PubMed
    6. Portran D, Schaedel L, Xu Z, Théry M, Nachury M. Tubulin acetylation protects long-lived microtubules against mechanical ageing. Nat Cell Biol. 2017 Apr; 19(4):391-398. PMID: 28250419.
      View in: PubMed
    7. Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury M. An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling. Cell. 2017 Jan 12; 168(1-2):252-263.e14. PMID: 28017328.
      View in: PubMed
    8. Langousis G, Shimogawa MM, Saada EA, Vashisht AA, Spreafico R, Nager AR, Barshop WD, Nachury M, Wohlschlegel JA, Hill KL. Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):632-7. PMID: 26721397; PMCID: PMC4725476.
    9. Mick DU, Rodrigues RB, Leib RD, Adams CM, Chien AS, Gygi SP, Nachury M. Proteomics of Primary Cilia by Proximity Labeling. Dev Cell. 2015 Nov 23; 35(4):497-512. PMID: 26585297; PMCID: PMC4662609 [Available on 11/23/16].
    10. See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury M, Kapoor TM, Chen JK. Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. ACS Chem Biol. 2016 Jan 15; 11(1):53-60. PMID: 26555042; PMCID: PMC4715766.
    11. Schaedel L, John K, Gaillard J, Nachury M, Blanchoin L, Théry M. Microtubules self-repair in response to mechanical stress. Nat Mater. 2015 Nov; 14(11):1156-63. PMID: 26343914; PMCID: PMC4620915.
    12. Luca VC, Jude KM, Pierce NW, Nachury M, Fischer S, Garcia KC. Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science. 2015 Feb 20; 347(6224):847-53. PMID: 25700513; PMCID: PMC4445638.
    13. Breslow DK, Nachury M. Analysis of soluble protein entry into primary cilia using semipermeabilized cells. Methods Cell Biol. 2015; 127:203-21. PMID: 25837393; PMCID: PMC4797650.
    14. Mourão A, Nager AR, Nachury M, Lorentzen E. Structural basis for membrane targeting of the BBSome by ARL6. Nat Struct Mol Biol. 2014 Dec; 21(12):1035-41. PMID: 25402481; PMCID: PMC4255524.
    15. Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury M. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev Cell. 2014 Nov 10; 31(3):265-78. PMID: 25443296; PMCID: PMC4255629.
    16. Nachury M. How do cilia organize signalling cascades? Philos Trans R Soc Lond B Biol Sci. 2014 Sep 05; 369(1650). PMID: 25047619; PMCID: PMC4113109.
    17. Thauvin-Robinet C, Lee JS, Lopez E, Herranz-Pérez V, Shida T, Franco B, Jego L, Ye F, Pasquier L, Loget P, Gigot N, Aral B, Lopes CA, St-Onge J, Bruel AL, Thevenon J, González-Granero S, Alby C, Munnich A, Vekemans M, Huet F, Fry AM, Saunier S, Rivière JB, Attié-Bitach T, Garcia-Verdugo JM, Faivre L, Mégarbané A, Nachury M. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nat Genet. 2014 Aug; 46(8):905-11. PMID: 24997988; PMCID: PMC4120243.
    18. Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury M. Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol Biol Cell. 2014 Jun 15; 25(12):1854-66. PMID: 24743598; PMCID: PMC4055265.
    19. Howes SC, Alushin GM, Shida T, Nachury M, Nogales E. Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure. Mol Biol Cell. 2014 Jan; 25(2):257-66. PMID: 24227885; PMCID: PMC3890346.
    20. Pierce NW, Nachury M. Cilia grow by taking a bite out of the cell. Dev Cell. 2013 Oct 28; 27(2):126-7. PMID: 24176638; PMCID: PMC3890250.
    21. Breslow DK, Koslover EF, Seydel F, Spakowitz AJ, Nachury M. An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. J Cell Biol. 2013 Oct 14; 203(1):129-47. PMID: 24100294; PMCID: PMC3798247.
    22. Montagnac G, Meas-Yedid V, Irondelle M, Castro-Castro A, Franco M, Shida T, Nachury M, Benmerah A, Olivo-Marin JC, Chavrier P. αTAT1 catalyses microtubule acetylation at clathrin-coated pits. Nature. 2013 Oct 24; 502(7472):567-70. PMID: 24097348; PMCID: PMC3970258.
    23. Scheidecker S, Etard C, Pierce NW, Geoffroy V, Schaefer E, Muller J, Chennen K, Flori E, Pelletier V, Poch O, Marion V, Stoetzel C, Strähle U, Nachury M, Dollfus H. Exome sequencing of Bardet-Biedl syndrome patient identifies a null mutation in the BBSome subunit BBIP1 (BBS18). J Med Genet. 2014 Feb; 51(2):132-6. PMID: 24026985; PMCID: PMC3966300.
    24. Ye F, Breslow DK, Koslover EF, Spakowitz AJ, Nelson WJ, Nachury M. Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors. Elife. 2013 Aug 06; 2:e00654. PMID: 23930224; PMCID: PMC3736543.
    25. Friedmann DR, Aguilar A, Fan J, Nachury M, Marmorstein R. Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19655-60. PMID: 23071314; PMCID: PMC3511727.
    26. Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury M, Sheffield VC. A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genet. 2011 Nov; 7(11):e1002358. PMID: 22072986; PMCID: PMC3207910.
    27. Nachury M. Give chance a chance. Mol Biol Cell. 2011 Nov; 22(21):3919-20. PMID: 22039061; PMCID: PMC3204048.
    28. Breslow DK, Nachury M. Primary cilia: how to keep the riff-raff in the plasma membrane. Curr Biol. 2011 Jun 07; 21(11):R434-6. PMID: 21640903.
      View in: PubMed
    29. Westlake CJ, Baye LM, Nachury M, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK. Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2759-64. PMID: 21273506; PMCID: PMC3041065.
    30. Shida T, Cueva JG, Xu Z, Goodman MB, Nachury M. The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21517-22. PMID: 21068373; PMCID: PMC3003046.
    31. Nachury M. Maxence Nachury: a transporting view of the primary cilium. Interview by Ben Short. J Cell Biol. 2010 Nov 01; 191(3):436-7. PMID: 21041439; PMCID: PMC3003325.
    32. Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury M. The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell. 2010 Jun 25; 141(7):1208-19. PMID: 20603001; PMCID: PMC2898735.
    33. Hu Q, Milenkovic L, Jin H, Scott MP, Nachury M, Spiliotis ET, Nelson WJ. A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science. 2010 Jul 23; 329(5990):436-9. PMID: 20558667; PMCID: PMC3092790.
    34. Seeley ES, Nachury M. The perennial organelle: assembly and disassembly of the primary cilium. J Cell Sci. 2010 Feb 15; 123(Pt 4):511-8. PMID: 20144999; PMCID: PMC2818191.
    35. Nachury M, Seeley ES, Jin H. Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Annu Rev Cell Dev Biol. 2010; 26:59-87. PMID: 19575670; PMCID: PMC2952038.
    36. Seeley ES, Nachury M. Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer. Methods Cell Biol. 2009; 94:299-313. PMID: 20362097; PMCID: PMC2885964.
    37. Jin H, Nachury M. The BBSome. Curr Biol. 2009 Jun 23; 19(12):R472-3. PMID: 19549489.
      View in: PubMed
    38. Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury M. A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Dev Cell. 2008 Dec; 15(6):854-65. PMID: 19081074.
      View in: PubMed
    39. Berdougo E, Nachury M, Jackson PK, Jallepalli PV. The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle. 2008 May 01; 7(9):1184-90. PMID: 18418058.
      View in: PubMed
    40. Nachury M. Tandem affinity purification of the BBSome, a critical regulator of Rab8 in ciliogenesis. Methods Enzymol. 2008; 439:501-13. PMID: 18374185.
      View in: PubMed
    41. Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury M, Tung JJ, Rieder CL, Jackson PK. The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev Cell. 2007 Jul; 13(1):29-42. PMID: 17609108.
      View in: PubMed
    42. Nachury M, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell. 2007 Jun 15; 129(6):1201-13. PMID: 17574030.
      View in: PubMed
    43. Miller JJ, Summers MK, Hansen DV, Nachury M, Lehman NL, Loktev A, Jackson PK. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 2006 Sep 01; 20(17):2410-20. PMID: 16921029; PMCID: PMC1560415.
    44. Blower MD, Nachury M, Heald R, Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell. 2005 Apr 22; 121(2):223-34. PMID: 15851029.
      View in: PubMed
    45. Kaiser BK, Nachury M, Gardner BE, Jackson PK. Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. BMC Cell Biol. 2004 Jul 13; 5:27. PMID: 15251038; PMCID: PMC481057.
    46. Nachury M, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell. 2001 Jan 12; 104(1):95-106. PMID: 11163243.
      View in: PubMed
    47. Nachury M, Weis K. The direction of transport through the nuclear pore can be inverted. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9622-7. PMID: 10449743; PMCID: PMC22259.
    48. Nachury M, Ryder UW, Lamond AI, Weis K. Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):582-7. PMID: 9435235; PMCID: PMC18463.
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