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Christian Vaisse, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentDiabetes Center
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-514-0530
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    Collapse Research 
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    Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite
    NIH/NIDDK R01DK106404Jun 1, 2016 - Apr 30, 2020
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH/NIDDK P30DK098722Aug 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Identification &functional characterization of SIM1 obesity-associated variants
    NIH/NIDDK R01DK090382May 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Role of Pro-opiomelanocortin mutations in human obesity
    NIH/NIDDK R01DK068152Sep 15, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Diabetes Research Center
    NIH/NIDDK P30DK063720Sep 1, 2002 - Mar 31, 2020
    Role: Co-Investigator
    The Melanocortin-4 Receptor in Human Obesity
    NIH/NIDDK R01DK060540Feb 15, 2002 - Apr 30, 2019
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

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    Collapse Global Health

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 Jun 13; 19(11):2257-2271. PMID: 28614713.
      View in: PubMed
    2. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR. The Association of Serum Leptin with Mortality in Older Adults. PLoS One. 2015; 10(10):e0140763. PMID: 26473487; PMCID: PMC4608587.
    3. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One. 2014; 9(5):e96805. PMID: 24820477; PMCID: PMC4018404.
    4. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17. PMID: 24574081; PMCID: PMC4159941.
    5. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. Functional characterization of SIM1-associated enhancers. Hum Mol Genet. 2014 Apr 01; 23(7):1700-8. PMID: 24203700; PMCID: PMC3943516.
    6. Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. Int J Obes (Lond). 2014 Jan; 38(1):148-51. PMID: 23649472; PMCID: PMC4648369.
    7. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg. 2011 Jul; 21(7):930-4. PMID: 20957447; PMCID: PMC3119798.
    8. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93. PMID: 20941479; PMCID: PMC3132390.
    9. Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C. Bariatric surgery in a patient with complete MC4R deficiency. Int J Obes (Lond). 2011 Mar; 35(3):457-61. PMID: 20733581; PMCID: PMC4648366.
    10. Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 2010 Jan; 46(1):217-25. PMID: 19853069; PMCID: PMC4501030.
    11. Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J. 2009 Sep; 23(9):3059-69. PMID: 19417090; PMCID: PMC2735358.
    12. Calton MA, Vaisse C. Narrowing down the role of common variants in the genetic predisposition to obesity. Genome Med. 2009 Mar 11; 1(3):31. PMID: 19341502.
      View in: PubMed
    13. Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clin Endocrinol (Oxf). 2009 Sep; 71(3):388-93. PMID: 19170711.
      View in: PubMed
    14. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7. PMID: 19091795; PMCID: PMC2649015.
    15. Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. J Clin Endocrinol Metab. 2008 Dec; 93(12):4955-62. PMID: 18765507; PMCID: PMC2729235.
    16. Ranadive SA, Vaisse C. Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am. 2008 Sep; 37(3):733-51, x. PMID: 18775361.
      View in: PubMed
    17. Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr Res. 2008 Feb; 63(2):211-6. PMID: 18091355.
      View in: PubMed
    18. Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Diabetes Obes Metab. 2008 Sep; 10(10):912-20. PMID: 18093211.
      View in: PubMed
    19. Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007 Aug 01; 2(7):e668. PMID: 17668051; PMCID: PMC1930153.
    20. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA. Medical sequencing at the extremes of human body mass. Am J Hum Genet. 2007 Apr; 80(4):779-91. PMID: 17357083; PMCID: PMC1852707.
    21. Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab. 2006 May; 91(5):1811-8. PMID: 16507637.
      View in: PubMed
    22. Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides. 2005 Oct; 26(10):1909-19. PMID: 16083993.
      View in: PubMed
    23. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C. Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol. 2005 Sep; 3(9):e315. PMID: 16122350; PMCID: PMC1193520.
    24. Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. J Clin Endocrinol Metab. 2005 Aug; 90(8):4446-51. PMID: 15914531.
      View in: PubMed
    25. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005 Mar 24; 434(7032):514-20. PMID: 15724149.
      View in: PubMed
    26. Picard F, Robin S, Lavielle M, Vaisse C, Daudin JJ. A statistical approach for array CGH data analysis. BMC Bioinformatics. 2005 Feb 11; 6:27. PMID: 15705208; PMCID: PMC549559.
    27. Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C. PAX4 gene variations predispose to ketosis-prone diabetes. Hum Mol Genet. 2004 Dec 15; 13(24):3151-9. PMID: 15509590.
      View in: PubMed
    28. Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest. 2004 Oct; 114(8):1158-64. PMID: 15489963; PMCID: PMC522250.
    29. Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C. A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans. J Clin Endocrinol Metab. 2004 May; 89(5):2028-32. PMID: 15126516.
      View in: PubMed
    30. Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Diabetes. 2004 Mar; 53(3):645-53. PMID: 14988248.
      View in: PubMed
    31. Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C. The human MC4R promoter: characterization and role in obesity. Diabetes. 2003 Dec; 52(12):2996-3000. PMID: 14633862.
      View in: PubMed
    32. Swarbrick MM, Vaisse C. Emerging trends in the search for genetic variants predisposing to human obesity. Curr Opin Clin Nutr Metab Care. 2003 Jul; 6(4):369-75. PMID: 12806208.
      View in: PubMed
    33. Srinivasan S, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann N Y Acad Sci. 2003 Jun; 994:225-32. PMID: 12851320.
      View in: PubMed
    34. Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C. Molecular genetics of human obesity-associated MC4R mutations. Ann N Y Acad Sci. 2003 Jun; 994:49-57. PMID: 12851297.
      View in: PubMed
    35. Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet. 2003 Jan 15; 12(2):145-53. PMID: 12499395.
      View in: PubMed
    36. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS. Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med. 2002 Jul; 8(7):643-4. PMID: 12091883.
      View in: PubMed
    37. Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. Hum Hered. 2000 Nov-Dec; 50(6):370-81. PMID: 10899756.
      View in: PubMed
    38. Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B. Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes. 2000 Aug; 49(8):1347-52. PMID: 10923636.
      View in: PubMed
    39. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest. 2000 Jul; 106(2):253-62. PMID: 10903341; PMCID: PMC314306.
    40. Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord. 2000 Mar; 24(3):391-3. PMID: 10757637.
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    41. Mueller MD, Vigne JL, Vaisse C, Taylor RN. Glycodelin: a pane in the implantation window. Semin Reprod Med. 2000; 18(3):289-98. PMID: 11299967.
      View in: PubMed
    42. Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E. Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. J Clin Endocrinol Metab. 1998 Nov; 83(11):4006-12. PMID: 9814484.
      View in: PubMed
    43. Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 1998 Oct; 20(2):113-4. PMID: 9771699.
      View in: PubMed
    44. Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26; 392(6674):398-401. PMID: 9537324.
      View in: PubMed
    45. Vaisse C, Kim J, Espinosa R, Le Beau MM, Stoffel M. Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Diabetes. 1997 Aug; 46(8):1364-7. PMID: 9231664.
      View in: PubMed
    46. Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet. 1996 Sep; 14(1):95-7. PMID: 8782827.
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    47. Ruiz J, Blanché H, James RW, Garin MC, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P. Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet. 1995 Sep 30; 346(8979):869-72. PMID: 7564671.
      View in: PubMed
    48. Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 1995 Aug 10; 333(6):352-4. PMID: 7609752.
      View in: PubMed
    49. Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nat Genet. 1995 Mar; 9(3):299-304. PMID: 7773293.
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    50. Mellon SH, Kushner JA, Vaisse C. Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. DNA Cell Biol. 1991 Jun; 10(5):339-47. PMID: 1863358.
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    51. Van Cong N, Vaisse C, Gross MS, Slim R, Milgrom E, Bernheim A. The human placental protein 14 (PP14) gene is localized on chromosome 9q34. Hum Genet. 1991 Mar; 86(5):515-8. PMID: 2016092.
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    52. Vaisse C, Atger M, Potier B, Milgrom E. Human placental protein 14 gene: sequence and characterization of a short duplication. DNA Cell Biol. 1990 Jul-Aug; 9(6):401-13. PMID: 2206398.
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    53. Mellon SH, Vaisse C. cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7775-9. PMID: 2554289; PMCID: PMC298153.
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