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Steve Fancy, PhD, DVM

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7636
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    Cambridge University, United KingdomPhD
    Cambridge University, United KingdomVetMB
    Cambridge University, United KingdomMA
    Cambridge University, United KingdomBA

    Collapse Overview 
    Collapse Overview
    Oligodendrocytes are the myelinating cells of the CNS that enable formation of myelin and saltatory nerve conduction. In Multiple Sclerosis (MS), the most common cause of neurological disability in young adults, myelin sheaths are lost through injury or death of mature oligodendrocytes (OL) as a result of autoimmune damage. White matter disorders are also associated with human newborn neurological injuries leading to Cerebral palsy (CP). CP complicates over 3.3/1000 live births in the United States and the incidence of this devastating condition is on the rise due to the increasing rates of survival of very low birth weight premature infants. In these conditions, myelin sheaths can be regenerated by oligodendrocyte progenitors (OLP) that are recruited to lesions and differentiate in a process called remyelination. But evidence suggests that myelin repair often fails in these diseases and this inhibition of remyelination contributes significantly to ongoing neurological dysfunction, axonal loss and disease progression. In order to understand the regulatory factors relevant in human myelin disorders, it is first critical to understand the cellular mechanisms regulating developmental myelination and the remyelination repair process following injury. My lab is a developmental biology lab, with a disease/injury repair orientation, and access to human developmental brain and MS tissue.

    Major Mechanistic and Translational goals:(1) identification of novel factors critical to murine developmental myelination, a questioning of their recapitulation in adult murine remyelination, and validation in human pathological white matter injury tissue (2) gaining a greater understanding of the human white matter lesion as a dysregulated repair environment, and why myelin repair fails in human demyelinating injuries (3) identification and testing of therapeutics to promote repair in human white matter injury.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019 05; 22(5):709-718. Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. PMID: 30988524.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    2. Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors. Glia. 2019 07; 67(7):1374-1384. Baror R, Neumann B, Segel M, Chalut KJ, Fancy SPJ, Schafer DP, Franklin RJM. PMID: 30861188.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. Nat Commun. 2018 08 21; 9(1):2862. Daynac M, Chouchane M, Collins HY, Murphy NE, Andor N, Niu J, Fancy SPJ, Stallcup WB, Petritsch CK. PMID: 30131568.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron. 2018 08 22; 99(4):689-701.e5. Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F. PMID: 30078577.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain. 2018 01 01; 141(1):85-98. Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ. PMID: 29244098.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    7. Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone. Dev Neurosci. 2016; 38(6):430-444. Dawes WJ, Zhang X, Fancy SPJ, Rowitch D, Marino S. PMID: 28343214.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27; 5. Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von B├╝dingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. PMID: 27671734.
      View in: PubMed   Mentions: 24     Fields:    
    9. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22; 351(6271):379-84. Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. PMID: 26798014.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    10. Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. J Neurosci. 2015 Aug 19; 35(33):11482-99. Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ. PMID: 26290228.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9. Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. PMID: 25946682.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18; 85(6):1227-43. Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B. PMID: 25754822.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell. 2014 Jul 17; 158(2):383-396. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH. PMID: 25018103.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    14. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014 Aug; 20(8):954-960. Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR. PMID: 24997607.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    15. Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci. 2014 Apr; 17(4):506-12. Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH. PMID: 24609463.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    16. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. PMID: 23840004.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    17. Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug; 72(2):224-33. Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B. PMID: 22807310.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science. 2012 Jul 20; 337(6092):358-62. Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH. PMID: 22745251.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    19. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304. Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR. PMID: 22160722.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    20. Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics. 2011 Oct; 8(4):650-8. Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ. PMID: 21904791.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci. 2011 Jun 26; 14(8):1009-16. Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH. PMID: 21706018.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    22. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43. Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. PMID: 21692657.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    23. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol. 2010 Nov; 68(5):703-16. Harrington EP, Zhao C, Fancy SP, Kaing S, Franklin RJ, Rowitch DH. PMID: 20853437.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    24. CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell. 2010 Jun 04; 6(6):578-90. Zawadzka M, Rivers LE, Fancy SP, Zhao C, Tripathi R, Jamen F, Young K, Goncharevich A, Pohl H, Rizzi M, Rowitch DH, Kessaris N, Suter U, Richardson WD, Franklin RJ. PMID: 20569695.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    25. Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol. 2010 Sep; 225(1):18-23. Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ. PMID: 20044992.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    26. Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination. J Neurosci Res. 2009 Nov 15; 87(15):3447-55. Zhao C, Fancy SP, Franklin RJ, ffrench-Constant C. PMID: 19739252.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    27. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 2009 Jul 01; 23(13):1571-85. Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH. PMID: 19515974.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    28. Comparison of sevoflurane and isoflurane in dogs anaesthetised for clinical surgical or diagnostic procedures. J Small Anim Pract. 2008 Aug; 49(8):392-7. Bennett RC, Fancy SP, Walsh CM, Brown AJ, Taylor PM. PMID: 18631219.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    29. Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination. Neurobiol Dis. 2008 Aug; 31(2):209-17. Zhao C, Fancy SP, ffrench-Constant C, Franklin RJ. PMID: 18539470.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    30. Olig gene function in CNS development and disease. Glia. 2006 Jul; 54(1):1-10. Ligon KL, Fancy SP, Franklin RJ, Rowitch DH. PMID: 16652341.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    31. Stem cells, progenitors and myelin repair. J Anat. 2005 Sep; 207(3):251-8. Zhao C, Fancy SP, Magy L, Urwin JE, Franklin RJ. PMID: 16185249.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    32. Mechanisms of CNS remyelination--the key to therapeutic advances. J Neurol Sci. 2005 Jun 15; 233(1-2):87-91. Zhao C, Fancy SP, Kotter MR, Li WW, Franklin RJ. PMID: 15949498.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    33. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004 Dec 17; 306(5704):2111-5. Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD. PMID: 15604411.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    34. Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. Mol Cell Neurosci. 2004 Nov; 27(3):247-54. Fancy SP, Zhao C, Franklin RJ. PMID: 15519240.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
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