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Michael Humphreys, MD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-502-3834
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Collapse Awards and Honors
    American Heart Association1999John Alexander, MD Research Award
    1991Elected to American Clinical and Climatological Association
    Case Western Reserve University1965Alpha Omega Alpha Society

    Collapse Overview 
    Collapse Overview
    Dr. Humphreys' primary research interest has been in sodium metabolism and the pathophysiology of edema formation and salt-sensitive hypertension. He and his colleagues identified that rodent models of sodium retention like nephrotic syndrome, liver cirrhosis, and pregnancy are characterized by resistance to the natriuretic actions of atrial natriuretic peptide (ANP), and this in turn is caused by a heightened activity of Type V phosphodiesterase (PDE), which catabolizes cGMP formed normally in renal collecting duct cells when ANP interacts with its renal receptors. Inhibition of Type V PDE restores ANP responsiveness in these models. His group has also identified a novel hormonal system involved in normal sodium metabolism in rodents. It involves a peptide hormone gamma-melanocyte stimulating hormone (g-MSH) released from the pituitary ACTH precursor proopiomelanocortin. When animals are fed a high salt diet, g-MSH synthesis and secretion are up-regulated; it acts on the kidneys to increase sodium excretion, and on the brain to dampen down sympathetic excitation which occurs with high sodium intakes. When rodents have impaired ability to increase g-MSH secretion during ingestion of the high sodium diet, or lack the melanocortinr receptor with which it interacts, marked hypertension develops, and is accompanied by insulin resistance.
    Dr. Humphreys has also done clinical research in these areas and has studied the occurrence of HIV-associated nephropathy in patients at San Francisco General Hospital. He participated in early studies measuring nitrogen balance in ESRD patients treated with hemodialysis, and was for a short time a site director for the Frequent Hemodialysis Network clinical trial.


    Collapse Research 
    Collapse Research Activities and Funding
    gamma-MSH and Sodium Metabolism
    NIH/NHLBI R01HL068871Apr 1, 2003 - Mar 31, 2009
    Role: Principal Investigator
    BASIS FOR RENAL RESISTANCE TO ATRIAL NATRIURETIC PEPTIDE
    NIH/NIDDK R01DK058812Mar 1, 2001 - Jan 31, 2006
    Role: Principal Investigator
    REFLEX CONTROL OF COMPENSATORY RENAL GROWTH &FUNCTION
    NIH/NIDDK R01DK031623Mar 1, 1983 - Nov 30, 1993
    Role: Principal Investigator
    REFLEX CONTROL OF COMPENSATORY RENAL GROWTH AND FUNCTION
    NIH/NIADDK R01AM031623Mar 1, 1983 - Feb 28, 1986
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Humphreys M. Renal nerves and CKD: is renal denervation the answer? J Am Soc Nephrol. 2012 Jul; 23(7):1132-5. PMID: 22677558.
      View in: PubMed
    2. Humphreys M. The brain splits obesity and hypertension. Nat Med. 2011 Jul; 17(7):782-3. PMID: 21738154.
      View in: PubMed
    3. Humphreys M, Ni XP, Pearce D. Cardiovascular effects of melanocortins. Eur J Pharmacol. 2011 Jun 11; 660(1):43-52. PMID: 21199648; PMCID: PMC3086937.
    4. Sasser JM, Ni XP, Humphreys M, Baylis C. Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F810-4. PMID: 20668100; PMCID: PMC2957261.
    5. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys M, Gardner DG. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. PMID: 19436108; PMCID: PMC2689130.
    6. Ni XP, van Dijk C, Pearce D, Humphreys M. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone. Exp Physiol. 2009 Aug; 94(8):867-76. PMID: 19429645; PMCID: PMC2853237.
    7. Ni XP, Humphreys M. Abnormal glucose metabolism in hypertensive mice with genetically interrupted gamma-melanocyte stimulating hormone signaling fed a high-sodium diet. Am J Hypertens. 2008 Dec; 21(12):1284-7. PMID: 18802429; PMCID: PMC3035849.
    8. Ni XP, Humphreys M. Prevention of salt-induced hypertension by an analog of gamma-melanocyte-stimulating hormone in the rat. Am J Hypertens. 2007 Aug; 20(8):862-5. PMID: 17679034.
      View in: PubMed
    9. Humphreys M. Cardiovascular and renal actions of melanocyte-stimulating hormone peptides. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):32-8. PMID: 17143069.
      View in: PubMed
    10. Ni XP, Butler AA, Cone RD, Humphreys M. Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones. J Hypertens. 2006 Nov; 24(11):2239-46. PMID: 17053546.
      View in: PubMed
    11. Knight S, Snellen H, Humphreys M, Baylis C. Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F655-9. PMID: 17003222; PMCID: PMC2765210.
    12. Ni XP, Bhargava A, Pearce D, Humphreys M. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R560-7. PMID: 16195498.
      View in: PubMed
    13. Chen S, Ni XP, Humphreys M, Gardner DG. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. PMID: 15590756.
      View in: PubMed
    14. Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys M, Kopple JD. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004 Aug; 80(2):299-307. PMID: 15277149.
      View in: PubMed
    15. Ni XP, Safai M, Rishi R, Baylis C, Humphreys M. Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat. J Am Soc Nephrol. 2004 May; 15(5):1254-60. PMID: 15100365; PMCID: PMC2756797.
    16. Kalantar-Zadeh K, Kopple JD, Humphreys M, Block G. Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patients. Nephrol Dial Transplant. 2004 Jun; 19(6):1507-19. PMID: 15069177.
      View in: PubMed
    17. Humphreys M. Gamma-MSH, sodium metabolism, and salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol. 2004 Mar; 286(3):R417-30. PMID: 14761863.
      View in: PubMed
    18. Kalantar-Zadeh K, Block G, Humphreys M, McAllister CJ, Kopple JD. A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients. J Am Soc Nephrol. 2004 Feb; 15(2):442-53. PMID: 14747392.
      View in: PubMed
    19. Kalantar-Zadeh K, Rodriguez RA, Humphreys M. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant. 2004 Jan; 19(1):141-9. PMID: 14671049.
      View in: PubMed
    20. Mayan H, Ni XP, Almog S, Humphreys M. Suppression of gamma-melanocyte-stimulating hormone secretion is accompanied by salt-sensitive hypertension in the rat. Hypertension. 2003 Nov; 42(5):962-7. PMID: 14568996.
      View in: PubMed
    21. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys M. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest. 2003 Apr; 111(8):1251-8. PMID: 12697744; PMCID: PMC152936.
    22. Kalantar-Zadeh K, Block G, Humphreys M, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int. 2003 Mar; 63(3):793-808. PMID: 12631061.
      View in: PubMed
    23. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 6; 277(36):32498-504. PMID: 12082097.
      View in: PubMed
    24. Kalantar-Zadeh K, Kopple JD, Block G, Humphreys M. Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis. J Am Soc Nephrol. 2001 Dec; 12(12):2797-806. PMID: 11729250.
      View in: PubMed
    25. Kalantar-Zadeh K, Kopple JD, Block G, Humphreys M. A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis. 2001 Dec; 38(6):1251-63. PMID: 11728958.
      View in: PubMed
    26. Chandramohan G, Ni XP, Kalinyak JE, Humphreys M. Dietary sodium modulates mRNA abundance of enzymes involved in pituitary processing of proopiomelanocortin. Pituitary. 2001 Sep; 4(4):231-7. PMID: 12501973.
      View in: PubMed
    27. Ni XP, Safai M, Gardner DG, Humphreys M. Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation. Kidney Int. 2001 Apr; 59(4):1264-73. PMID: 11260387.
      View in: PubMed
    28. Humphreys M. Salt intake and body fluid volumes: have we learned all there is to know? Am J Kidney Dis. 2001 Mar; 37(3):648-52. PMID: 11228194.
      View in: PubMed
    29. Kalantar-Zadeh K, Don BR, Rodriguez RA, Humphreys M. Serum ferritin is a marker of morbidity and mortality in hemodialysis patients. Am J Kidney Dis. 2001 Mar; 37(3):564-72. PMID: 11228181.
      View in: PubMed
    30. Berkhin EB, Humphreys M. Regulation of renal tubular secretion of organic compounds. Kidney Int. 2001 Jan; 59(1):17-30. PMID: 11135053.
      View in: PubMed
    31. Kalantar-Zadeh K, Block G, Kelly MP, Schroepfer C, Rodriguez RA, Humphreys M. Near infra-red interactance for longitudinal assessment of nutrition in dialysis patients. J Ren Nutr. 2001 Jan; 11(1):23-31. PMID: 11172450.
      View in: PubMed
    32. Facchini FS, Humphreys M, DoNascimento CA, Abbasi F, Reaven GM. Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. Am J Clin Nutr. 2000 Sep; 72(3):776-9. PMID: 10966898.
      View in: PubMed
    33. Abbasi F, Facchini F, Humphreys M, Reaven GM. Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal. Atherosclerosis. 1999 Sep; 146(1):175-8. PMID: 10487501.
      View in: PubMed
    34. Jayasekara D, Aweeka FT, Rodriguez R, Kalayjian RC, Humphreys M, Gambertoglio JG. Antiviral therapy for HIV patients with renal insufficiency. J Acquir Immune Defic Syndr. 1999 Aug 15; 21(5):384-95. PMID: 10458619.
      View in: PubMed
    35. Kalantar-Zadeh K, Luft FC, Humphreys M. Moderately high serum ferritin concentration is not a sign of iron overload in dialysis patients. Kidney Int. 1999 Aug; 56(2):758-9. PMID: 10432420.
      View in: PubMed
    36. Facchini F, Humphreys M, Jeppesen J, Reaven GM. Measurements of insulin-mediated glucose disposal are stable over time. J Clin Endocrinol Metab. 1999 May; 84(5):1567-9. PMID: 10323381.
      View in: PubMed
    37. Facchini FS, DoNascimento C, Reaven GM, Yip JW, Ni XP, Humphreys M. Blood pressure, sodium intake, insulin resistance, and urinary nitrate excretion. Hypertension. 1999 Apr; 33(4):1008-12. PMID: 10205239.
      View in: PubMed
    38. Brody SR, Humphreys M, Gambertoglio JG, Schoenfeld P, Cundy KC, Aweeka FT. Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis. Clin Pharmacol Ther. 1999 Jan; 65(1):21-8. PMID: 9951427.
      View in: PubMed
    39. Cao L, Chen SC, Cheng T, Humphreys M, Gardner DG. Ligand-dependent regulation of NPR-A gene expression in inner medullary collecting duct cells. Am J Physiol. 1998 Jul; 275(1 Pt 2):F119-25. PMID: 9689013.
      View in: PubMed
    40. Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys M. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. Am J Physiol. 1998 Apr; 274(4 Pt 2):R931-8. PMID: 9575953.
      View in: PubMed
    41. Valentin JP, Ying WZ, Couser WG, Humphreys M. Extrarenal resistance to atrial natriuretic peptide in rats with experimental nephrotic syndrome. Am J Physiol. 1998 Mar; 274(3 Pt 2):F556-63. PMID: 9530272.
      View in: PubMed
    42. Valentin JP, Mazbar SA, Humphreys M. Long-term captopril treatment restores natriuresis after carotid baroreceptor activation in the SHR. Am J Physiol. 1997 Jul; 273(1 Pt 2):R70-9. PMID: 9249534.
      View in: PubMed
    43. Chen XW, Ying WZ, Valentin JP, Ling KT, Lin SY, Wiedemann E, Humphreys M. Mechanism of the natriuretic action of gamma-melanocyte-stimulating hormone. Am J Physiol. 1997 Jun; 272(6 Pt 2):R1946-53. PMID: 9227612.
      View in: PubMed
    44. Valentin JP, Sechi LA, Griffin CA, Humphreys M, Schambelan M. The renin-angiotensin system and compensatory renal hypertrophy in the rat. Am J Hypertens. 1997 Apr; 10(4 Pt 1):397-402. PMID: 9128205.
      View in: PubMed
    45. Ni X, Cheng Y, Cao L, Gardner DG, Humphreys M. Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation. J Am Soc Nephrol. 1996 Oct; 7(10):2110-8. PMID: 8915970.
      View in: PubMed
    46. Mayan H, Ling KT, Lee EY, Wiedemann E, Kalinyak JE, Humphreys M. Dietary sodium intake modulates pituitary proopiomelanocortin mRNA abundance. Hypertension. 1996 Aug; 28(2):244-9. PMID: 8707389.
      View in: PubMed
    47. Lee EY, Humphreys M. Phosphodiesterase activity as a mediator of renal resistance to ANP in pathological salt retention. Am J Physiol. 1996 Jul; 271(1 Pt 2):F3-6. PMID: 8760236.
      View in: PubMed
    48. Valentin JP, Ying WZ, Sechi LA, Ling KT, Qiu C, Couser WG, Humphreys M. Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis. J Am Soc Nephrol. 1996 Apr; 7(4):582-93. PMID: 8724892.
      View in: PubMed
    49. Humphreys M. Human immunodeficiency virus-associated glomerulosclerosis. Kidney Int. 1995 Aug; 48(2):311-20. PMID: 7564098.
      View in: PubMed
    50. Sechi LA, Valentin JP, Griffin CA, Lee E, Bartoli E, Humphreys M, Schambelan M. Receptors for atrial natriuretic peptide are decreased in the kidney of rats with streptozotocin-induced diabetes mellitus. J Clin Invest. 1995 Jun; 95(6):2451-7. PMID: 7769090; PMCID: PMC295920.
    51. Valentin JP, Qiu C, Wiedemann E, Gardner DG, Humphreys M. Modulation of ANP-dependent effects of endothelin by inhibitors of neutral endopeptidase and cGMP phosphodiesterase. J Pharmacol Exp Ther. 1995 May; 273(2):744-52. PMID: 7752077.
      View in: PubMed
    52. Valentin JP, Sechi LA, Humphreys M. [Resistance to hemoconcentration but non hypotensive action of atrial natriuretic peptide in diabetes mellitus induced by streptozocin in the rat]. Arch Mal Coeur Vaiss. 1994 Aug; 87(8):1119-23. PMID: 7755472.
      View in: PubMed
    53. Valentin JP, Sechi LA, Griffin CA, Humphreys M, Schambelan M. [Gene expression of the renin-angiotensin system in compensatory renal hypertrophy secondary to contralateral nephrectomy]. Arch Mal Coeur Vaiss. 1994 Aug; 87(8):1115-7. PMID: 7755471.
      View in: PubMed
    54. Valentin JP, Ying WZ, Sechi LA, Humphreys M. [Resistance to the action of atrial natriuretic peptide and urodilatin in Heymann nephritis in vitro]. Arch Mal Coeur Vaiss. 1994 Aug; 87(8):1125-9. PMID: 7755473.
      View in: PubMed
    55. Valentin JP, Sechi LA, Humphreys M. Blunted effect of ANP on hematocrit and plasma volume in streptozotocin-induced diabetes mellitus in rats. Am J Physiol. 1994 Feb; 266(2 Pt 2):R584-91. PMID: 8141419.
      View in: PubMed
    56. Humphreys M. Mechanisms and management of nephrotic edema. Kidney Int. 1994 Jan; 45(1):266-81. PMID: 8127018.
      View in: PubMed
    57. Humphreys M, Lin SY, Ying WZ, Wiedemann E. A gamma-melanocyte stimulating hormone and postnephrectomy natriuresis. Hypertension. 1993 Dec; 22(6):934-5. PMID: 8244525.
      View in: PubMed
    58. Valentin JP, Sechi LA, Griffin CA, Humphreys M, Schambelan M. Renin-angiotensin system gene expression during compensatory renal hypertrophy in the rat. J Hypertens Suppl. 1993 Dec; 11(5):S236-7. PMID: 8158362.
      View in: PubMed
    59. Valentin JP, Ying WZ, Sechi LA, Humphreys M. Atrial natriuretic peptide and blunted renal responses to volume expansion in rats with Heymann nephritis. J Hypertens Suppl. 1993 Dec; 11(5):S218-9. PMID: 8158353.
      View in: PubMed
    60. Humphreys M, Wiedemann E, Valentin JP, Chen XW, Ying WZ. Natriuretic actions of gamma-melanocyte-stimulating hormone. Ann N Y Acad Sci. 1993 May 31; 680:545-8. PMID: 8390189.
      View in: PubMed
    61. Valentin JP, Sechi LA, Qui C, Schambelan M, Humphreys M. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr; 21(4):432-8. PMID: 8384600.
      View in: PubMed
    62. Humphreys M, Valentin JP, Qiu C, Ying WZ, Muldowney WP, Gardner DG. Underfill and overflow revisited: mechanisms of nephrotic edema. Trans Am Clin Climatol Assoc. 1993; 104:47-59; discussion 59-60. PMID: 1343447; PMCID: PMC2376618.
    63. Valentin JP, Wiedemann E, Humphreys M. Natriuretic properties of melanocyte-stimulating hormones. J Cardiovasc Pharmacol. 1993; 22 Suppl 2:S114-8. PMID: 7508015.
      View in: PubMed
    64. Valentin JP, Humphreys M. Urodilatin: a paracrine renal natriuretic peptide. Semin Nephrol. 1993 Jan; 13(1):61-70. PMID: 8434187.
      View in: PubMed
    65. Qiu C, Valentin JP, Chen XW, Wiedemann E, Humphreys M. Acute unilateral nephrectomy elicits a specific increase in plasma of peptides derived from the N-terminal region of proopiomelanocortin. J Am Soc Nephrol. 1992 Nov; 3(5):1105-12. PMID: 1336405.
      View in: PubMed
    66. Valentin JP, Qiu C, Muldowney WP, Ying WZ, Gardner DG, Humphreys M. Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome. J Clin Invest. 1992 Oct; 90(4):1302-12. PMID: 1328296; PMCID: PMC443174.
    67. Valentin JP, Humphreys M. [Modulating effects of atrial natriuretic peptide on vascular permeability and blood pressure by inhibition of cyclic phosphodiesterase GMP in the rat]. Arch Mal Coeur Vaiss. 1992 Aug; 85(8):1219-22. PMID: 1336359.
      View in: PubMed
    68. Valentin JP, Qiu CB, Wiedemann E, Gardner D, Humphreys M. Inhibition of neutral endopeptidase amplifies the effects of endogenous atrial natriuretic peptide on blood pressure and fluid partition. Am J Hypertens. 1992 Feb; 5(2):88-91. PMID: 1532317.
      View in: PubMed
    69. Vannucchi MT, Vannucchi H, Humphreys M. Serum levels of vitamin A and retinol binding protein in chronic renal patients treated by continuous ambulatorial peritoneal dialysis. Int J Vitam Nutr Res. 1992; 62(2):107-12. PMID: 1517032.
      View in: PubMed
    70. Valentin JP, Mazbar SA, Humphreys M. Natriuretic effect of intermittent bilateral carotid artery traction in the rat. J Hypertens Suppl. 1991 Dec; 9(6):S86-7. PMID: 1819022.
      View in: PubMed
    71. Frassetto L, Schoenfeld PY, Humphreys M. Increasing incidence of human immunodeficiency virus-associated nephropathy at San Francisco General Hospital. Am J Kidney Dis. 1991 Dec; 18(6):655-9. PMID: 1962649.
      View in: PubMed
    72. Valentin JP, Gardner DG, Ribstein J, Mimran A, Humphreys M. [Extravascular transfer of fluids and proteins induced by endothelin in the binephrectomized rat]. Arch Mal Coeur Vaiss. 1991 Aug; 84(8):1159-62. PMID: 1835358.
      View in: PubMed
    73. Valentin JP, Gardner DG, Wiedemann E, Humphreys M. Modulation of endothelin effects on blood pressure and hematocrit by atrial natriuretic peptide. Hypertension. 1991 Jun; 17(6 Pt 2):864-9. PMID: 1828459.
      View in: PubMed
    74. Humphreys M. Urodilatin--renal natriuretic peptide? J Am Soc Nephrol. 1991 Mar; 1(9):1057-9. PMID: 1832981.
      View in: PubMed
    75. Humphreys M, Lin SY, Wiedemann E. Renal nerves and the natriuresis following unilateral renal exclusion in the rat. Kidney Int. 1991 Jan; 39(1):63-70. PMID: 2002634.
      View in: PubMed
    76. Mazbar SA, Wiedemann E, Humphreys M. Mechanism of the natriuretic effect of unilateral carotid artery traction in the rat. J Am Soc Nephrol. 1990 Sep; 1(3):266-71. PMID: 2104270.
      View in: PubMed
    77. Mazbar SA, Schoenfeld PY, Humphreys M. Renal involvement in patients infected with HIV: experience at San Francisco General Hospital. Kidney Int. 1990 May; 37(5):1325-32. PMID: 2345428.
      View in: PubMed
    78. Humphreys M. Human immunodeficiency virus-associated nephropathy. East is east and west is west? Arch Intern Med. 1990 Feb; 150(2):253-5. PMID: 2405796.
      View in: PubMed
    79. Humphreys M, Etheredge SB, Lin SY, Ribstein J, Marton LJ. Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat. Am J Physiol. 1988 Aug; 255(2 Pt 2):F270-7. PMID: 3136663.
      View in: PubMed
    80. Humphreys M, Lin SY. Peptide hormones and the regulation of sodium excretion. Hypertension. 1988 May; 11(5):397-410. PMID: 2966767.
      View in: PubMed
    81. Chaves C, Humphreys M. Amplification of the natriuretic response to acute unilateral nephrectomy by volume expansion. Miner Electrolyte Metab. 1988; 14(5):277-82. PMID: 3173265.
      View in: PubMed
    82. Lin SY, Chaves C, Wiedemann E, Humphreys M. A gamma-melanocyte stimulating hormone-like peptide causes reflex natriuresis after acute unilateral nephrectomy. Hypertension. 1987 Dec; 10(6):619-27. PMID: 3692573.
      View in: PubMed
    83. Lin SY, Wiedemann E, Deschepper CF, Alper RH, Humphreys M. Prevention of reflex natriuresis after acute unilateral nephrectomy by neonatal administration of MSG. Am J Physiol. 1987 Feb; 252(2 Pt 2):F276-82. PMID: 3812742.
      View in: PubMed
    84. Humphreys M, Schoenfeld PY. Renal complications in patients with the acquired immune deficiency syndrome (AIDS). Am J Nephrol. 1987; 7(1):1-7. PMID: 3555070.
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    85. Al-Bander HA, Mock DM, Etheredge SB, Paukert TT, Humphreys M, Morris RC. Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid. Kidney Int. 1986 Dec; 30(6):804-12. PMID: 3102828.
      View in: PubMed
    86. Humphreys M, Lin SY, Ribstein J, Wiedemann E. Reflex responses to reductions in functioning renal mass. Fed Proc. 1985 Oct; 44(13):2840-5. PMID: 2995143.
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    87. Lin SY, Humphreys M. Centrally administered naloxone blocks reflex natriuresis after acute unilateral nephrectomy. Am J Physiol. 1985 Sep; 249(3 Pt 2):F390-5. PMID: 3929623.
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    88. Lin SY, Wiedemann E, Humphreys M. Role of the pituitary in reflex natriuresis following acute unilateral nephrectomy. Am J Physiol. 1985 Aug; 249(2 Pt 2):F282-90. PMID: 3161342.
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    89. Al-Bander H, Etheredge SB, Paukert T, Humphreys M, Morris RC. Phosphate loading attenuates renal tubular dysfunction induced by maleic acid in the dog. Am J Physiol. 1985 Apr; 248(4 Pt 2):F513-21. PMID: 3985158.
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    90. Kaysen GA, Paukert TT, Menke DJ, Couser WG, Humphreys M. Plasma volume expansion is necessary for edema formation in the rate with Heymann nephritis. Am J Physiol. 1985 Feb; 248(2 Pt 2):F247-53. PMID: 3970214.
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    91. Al-Bander H, Court SB, Humphreys M. Determinants of the kaliuresis after acute unilateral nephrectomy in the dog. Miner Electrolyte Metab. 1985; 11(5):287-94. PMID: 4047005.
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    92. Ribstein J, Humphreys M. Renal nerves and cation excretion after acute reduction in functioning renal mass in the rat. Am J Physiol. 1984 Mar; 246(3 Pt 2):F260-5. PMID: 6703059.
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    93. Ribstein J, Humphreys M. Endogenous opioids and electrolyte excretion after contralateral renal exclusion. Am J Physiol. 1983 Apr; 244(4):F392-8. PMID: 6837737.
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    94. Humphreys M, Chou LY. Anion effects on fluid absorption from rat jejunum perfused in vivo. Am J Physiol. 1983 Jan; 244(1):G33-9. PMID: 6295185.
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    95. Al-Bander HA, Weiss RA, Humphreys M, Morris RC. Dysfunction of the proximal tubule underlies maleic acid-induced type II renal tubular acidosis. Am J Physiol. 1982 Dec; 243(6):F604-11. PMID: 7149027.
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    96. Ayus JC, Humphreys M. Hemodynamic and renal functional changes after acute unilateral nephrectomy in the dog: role of carotid sinus baroreceptors. Am J Physiol. 1982 Feb; 242(2):F181-9. PMID: 7065134.
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    97. Cogan JJ, Humphreys M, Carlson CJ, Benowitz NL, Rapaport E. Acute vasodilator therapy increases renal clearance of digoxin in patients with congestive heart failure. Circulation. 1981 Nov; 64(5):973-6. PMID: 7285311.
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    98. Humphreys M, Al-Bander H, Eneas JF, Schambelan M. Factors determining electrolyte excretion and renin secretion after closure of an arteriovenous fistula in the dog. J Lab Clin Med. 1981 Jul; 98(1):89-98. PMID: 7019367.
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    99. Humphreys M, Ayus JC, Stanton CJ. Prevention by vagotomy or atropine administration of the hemodynamic changes occurring after acute unilateral nephrectomy in the dog. Circ Res. 1980 Apr; 46(4):575-80. PMID: 7357705.
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    100. Benowitz N, Abolin C, Tozer T, Rosenberg J, Rogers W, Pond S, Schoenfeld P, Humphreys M. Resin hemoperfusion in ethychlorvynol overdose. Clin Pharmacol Ther. 1980 Feb; 27(2):236-42. PMID: 7353346.
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    101. Humphreys M, Kaysen GA, Chou LY, Watson JB. Anion-stimulated phosphohydrolase activity of intestinal alkaline phosphatase. Am J Physiol. 1980 Jan; 238(1):G3-9. PMID: 6153512.
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    102. Andrew OT, Schoenfeld PY, Hopewell PC, Humphreys M. Tuberculosis in patients with end-stage renal disease. Am J Med. 1980 Jan; 68(1):59-65. PMID: 7350806.
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    103. Eneas JF, Schoenfeld PY, Humphreys M. The effect of infusion of mannitol-sodium bicarbonate on the clinical course of myoglobinuria. Arch Intern Med. 1979 Jul; 139(7):801-5. PMID: 454069.
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    104. Ayus JC, Eneas JF, Tong TG, Benowitz NL, Schoenfeld PY, Hadley KL, Becker CE, Humphreys M. Peritoneal clearance and total body elimination of vancomycin during chronic intermittent peritoneal dialysis. Clin Nephrol. 1979 Mar; 11(3):129-32. PMID: 436339.
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    105. Humphreys M, Reid IA. Effects of clonidine on glucose and phosphate metabolism in the anesthetized dog. J Pharmacol Exp Ther. 1979 Feb; 208(2):243-7. PMID: 762655.
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    106. Humphreys M, Chou LY. Anion-stimulated ATPase activity of brush border from rat small intestine. Am J Physiol. 1979 Jan; 236(1):E70-6. PMID: 155403.
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    107. Borah MF, Schoenfeld PY, Gotch FA, Sargent JA, Wolfsen M, Humphreys M. Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int. 1978 Nov; 14(5):491-500. PMID: 750694.
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    108. Sargent J, Gotch F, Borah M, Piercy L, Spinozzi N, Schoenfeld P, Humphreys M. Urea kinetics: a guide to nutritional management of renal failure. Am J Clin Nutr. 1978 Sep; 31(9):1696-702. PMID: 99022.
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    109. Humphreys M, Ayus JC. Role of hemodynamic changes in the increased cation excretion after acute unilateral nephrectomy in the anesthetized dog. J Clin Invest. 1978 Mar; 61(3):590-6. PMID: 641140; PMCID: PMC372571.
    110. Humphreys M. Inhibition of NaCl absorption from perfused rat ileum by furosemide. Am J Physiol. 1976 Jun; 230(6):1517-23. PMID: 937541.
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    111. Beallo R, Dallman PR, Schoenfeld PY, Humphreys M. Serum ferritin and iron deficiency in patients on chronic hemodialysis. Trans Am Soc Artif Intern Organs. 1976; 22:73-9. PMID: 951893.
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    112. Humphreys M, Reid IA, Ufferman RC, Lieberman RA, Earley LE. The relationship between sodium excretion and renin secretion by the perfused kidney. Proc Soc Exp Biol Med. 1975 Dec; 150(3):728-34. PMID: 1208596.
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    113. Humphreys M, Reid IA, Chou LY. Suppression of antidiuretic hormone secretion by clonidine in the anesthetized dog. Kidney Int. 1975 Jun; 7(6):405-12. PMID: 1167185.
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    114. Earley LE, Humphreys M, Bartoli E. Capillary circulation as a regulator of sodium reabsorption and excretion. Circ Res. 1972 Sep; 31(9):Suppl 2:1-18. PMID: 5057027.
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    115. Schrier RW, Humphreys M. Role of distal reabsorption and peritubular environment in glomerulotubular balance. Am J Physiol. 1972 Feb; 222(2):379-87. PMID: 5058378.
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    116. Schrier RW, Humphreys M, Ufferman RC. Role of cardiac output and the autonomic nervous system in the antinatriuretic response to acute constriction of the thoracic superior vena cava. Circ Res. 1971 Nov; 29(5):490-8. PMID: 5120614.
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    117. Schrier RW, Humphreys M. Factors involved in antinatriuretic effects of acute constriction of the thoracic and abdominal inferior vena cava. Circ Res. 1971 Nov; 29(5):479-89. PMID: 5120613.
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    118. Humphreys M, Earley LE. The mechanism of decreased intestinal sodium and water absorption after acute volume expansion in the rat. J Clin Invest. 1971 Nov; 50(11):2355-67. PMID: 5096520; PMCID: PMC292178.
    119. Humphreys M, Friedler RM, Earley LE. Natrriuresis produced by vasopressin or hemorrhage during water diuresis in the dog. Am J Physiol. 1970 Sep; 219(3):658-65. PMID: 5450867.
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