Loading...

David Gardner, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-2729
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of ANP Receptor Activity in Vascular Cells
    NIH/NHLBI R01HL045637Jul 1, 1992 - Feb 28, 2013
    Role: Principal Investigator
    EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    NIH/NHLBI R01HL035753Sep 30, 1985 - Jun 30, 2004
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH/NCRR S07RR005890Apr 1, 1983 - Mar 31, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488; PMCID: PMC5001188 [Available on 09/01/17].
    2. Glenn DJ, Cardema MC, Gardner DG. Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. J Steroid Biochem Mol Biol. 2016 11; 164:292-298. PMID: 26429397.
      View in: PubMed
    3. Ni W, Glenn DJ, Gardner DG. Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance. J Steroid Biochem Mol Biol. 2016 11; 164:281-286. PMID: 26369613.
      View in: PubMed
    4. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS One. 2015; 10(7):e0131539. PMID: 26134669; PMCID: PMC4489761.
    5. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. Cardiac steatosis potentiates angiotensin II effects in the heart. Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H339-50. PMID: 25485904; PMCID: PMC4329483.
    6. Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG. Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Hypertension. 2014 Dec; 64(6):1290-8. PMID: 25201890; PMCID: PMC4430199.
    7. Gardner DG, Chen S, Glenn DJ. Vitamin D and the heart. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 01; 305(9):R969-77. PMID: 24026071; PMCID: PMC3840320.
    8. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. PMID: 23682710; PMCID: PMC3717170.
    9. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. PMID: 23337142.
      View in: PubMed
    10. Chen S, Gardner DG. Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart. J Steroid Biochem Mol Biol. 2013 Jul; 136:150-5. PMID: 22989481.
      View in: PubMed
    11. Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC. Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer. 2012 Aug; 19(4):497-508. PMID: 22645228.
      View in: PubMed
    12. Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E. Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F141-9. PMID: 21957179.
      View in: PubMed
    13. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011 Oct 25; 124(17):1838-47. PMID: 21947295; PMCID: PMC4160312.
    14. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. PMID: 21220706; PMCID: PMC3322545.
    15. Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG. A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. J Steroid Biochem Mol Biol. 2010 Nov; 122(5):326-32. PMID: 20813185; PMCID: PMC4143149.
    16. Chen S, Law CS, Gardner DG. Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. J Steroid Biochem Mol Biol. 2010 Feb 15; 118(3):135-41. PMID: 19961935; PMCID: PMC2830853.
    17. Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG. Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Cardiovasc Res. 2009 Nov 01; 84(2):209-17. PMID: 19546173; PMCID: PMC2761198.
    18. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. PMID: 19436108; PMCID: PMC2689130.
    19. Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG. Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. Hypertension. 2009 Mar; 53(3):549-55. PMID: 19139378; PMCID: PMC2710878.
    20. Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG. Expression of the vitamin d receptor is increased in the hypertrophic heart. Hypertension. 2008 Dec; 52(6):1106-12. PMID: 18936343; PMCID: PMC2690395.
    21. Glenn DJ, Gardner DG. Lipids and the heart: neither feast nor famine. Hypertension. 2007 Sep; 50(3):463-4. PMID: 17664386.
      View in: PubMed
    22. Gardner DG, Chen S, Glenn DJ, Grigsby CL. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension. 2007 Mar; 49(3):419-26. PMID: 17283251.
      View in: PubMed
    23. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Neurocrit Care. 2006; 5(3):180-5. PMID: 17290085.
      View in: PubMed
    24. Chen S, Qiong Y, Gardner DG. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006 Feb; 47(2):252-8. PMID: 16365184.
      View in: PubMed
    25. Rahmutula D, Gardner DG. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology. 2005 Nov; 146(11):4968-74. PMID: 16109786.
      View in: PubMed
    26. Chen S, Nakamura K, Gardner DG. 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30; 128(3):197-202. PMID: 15837528.
      View in: PubMed
    27. Chen S, Ni XP, Humphreys MH, Gardner DG. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. PMID: 15590756.
      View in: PubMed
    28. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E125-32. PMID: 15367398.
      View in: PubMed
    29. Rahmutula D, Cui J, Chen S, Gardner DG. Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1. Hypertension. 2004 Sep; 44(3):283-8. PMID: 15262909.
      View in: PubMed
    30. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. PMID: 15007040.
      View in: PubMed
    31. Chen S, Gardner DG. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem. 2004 Apr 02; 279(14):13755-63. PMID: 14742443.
      View in: PubMed
    32. Anderson HD, Wang F, Gardner DG. Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004 Mar 05; 279(10):9287-97. PMID: 14645255.
      View in: PubMed
    33. Gardner DG. Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab. 2003 Nov; 14(9):411-6. PMID: 14580760.
      View in: PubMed
    34. Anderson HD, Rahmutula D, Gardner DG. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004 Jan 09; 279(2):963-9. PMID: 14581470.
      View in: PubMed
    35. Liang F, Wang F, Zhang S, Gardner DG. Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology. 2003 Sep; 144(9):4187-94. PMID: 12933694.
      View in: PubMed
    36. Gardner DG. Brain natriuretic peptide: a marker for subclinical cardiovascular disease? Am J Med. 2003 Mar; 114(4):329-30. PMID: 12681464.
      View in: PubMed
    37. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21; 92(3):300-7. PMID: 12595342.
      View in: PubMed
    38. Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG. Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. J Biol Chem. 2003 Apr 25; 278(17):15073-83. PMID: 12562779.
      View in: PubMed
    39. Ye Q, Chen S, Gardner DG. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Hypertension. 2003 Mar; 41(3 Pt 2):675-81. PMID: 12623978.
      View in: PubMed
    40. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 06; 277(36):32498-504. PMID: 12082097.
      View in: PubMed
    41. Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC. Thyroid hormone export varies among primary cells and appears to differ from hormone uptake. Endocrinology. 2002 Feb; 143(2):476-83. PMID: 11796501.
      View in: PubMed
    42. Gardner DG. Manipulating the renin-angiotensin system: more than we bargained for? Am J Med. 2002 Feb 01; 112(2):152-3. PMID: 11835956.
      View in: PubMed
    43. Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D. Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes. Cell Mol Biol Lett. 2002; 7(2):323-9. PMID: 12097978.
      View in: PubMed
    44. Chen S, Gardner DG. Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK. J Biol Chem. 2002 Feb 22; 277(8):6037-43. PMID: 11744737.
      View in: PubMed