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David Gardner, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-476-2729
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of ANP Receptor Activity in Vascular Cells
    NIH/NHLBI R01HL045637Jul 1, 1992 - Feb 28, 2013
    Role: Principal Investigator
    EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    NIH/NHLBI R01HL035753Sep 30, 1985 - Jun 30, 2004
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH/NCRR S07RR005890Apr 1, 1983 - Mar 31, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488.
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    2. Glenn DJ, Cardema MC, Gardner DG. Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. J Steroid Biochem Mol Biol. 2016 11; 164:292-298. PMID: 26429397.
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    3. Ni W, Glenn DJ, Gardner DG. Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance. J Steroid Biochem Mol Biol. 2016 11; 164:281-286. PMID: 26369613.
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    4. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS One. 2015; 10(7):e0131539. PMID: 26134669.
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    5. Bishop D, Christiansen D, Bartlett J, Gardner D, Craigon J, Goodall S, Thomas K, Temesi J, Millet GY, Cattagni T, Lepers R, Deaner RO, Guenette JA, Pageaux B, Lepers R, Lepers R, Stapley PJ, Cattagni T, Sparling PB, Santos-Lozano A, Garatachea N, Sanchis-Gomar F, Pareja-Galeano H, Fiuza-Luces C, Lucia A, Ward SA. Commentaries on Viewpoint: The two-hour marathon: what's the equivalent for women? J Appl Physiol (1985). 2015 May 15; 118(10):1324-8. PMID: 25979937.
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    6. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. Cardiac steatosis potentiates angiotensin II effects in the heart. Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H339-50. PMID: 25485904.
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    7. Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG. Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Hypertension. 2014 Dec; 64(6):1290-8. PMID: 25201890.
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    8. Gardner DG, Chen S, Glenn DJ. Vitamin D and the heart. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 01; 305(9):R969-77. PMID: 24026071.
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    9. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. PMID: 23682710.
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    10. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. PMID: 23337142.
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    11. Chen S, Gardner DG. Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart. J Steroid Biochem Mol Biol. 2013 Jul; 136:150-5. PMID: 22989481.
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    12. Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC. Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer. 2012 Aug; 19(4):497-508. PMID: 22645228.
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    13. Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E. Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F141-9. PMID: 21957179.
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    14. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011 Oct 25; 124(17):1838-47. PMID: 21947295.
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    15. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. PMID: 21220706.
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    16. David G. Gardner, Songcang Chen, Denis J. Glenn, Wei Ni. Chapter 31 Vitamin D and the Cardiovascular System. Vitamin D. 2011 Jan 1; 541-563.
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    17. Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG. A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. J Steroid Biochem Mol Biol. 2010 Nov; 122(5):326-32. PMID: 20813185.
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    18. Chen S, Law CS, Gardner DG. Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. J Steroid Biochem Mol Biol. 2010 Feb 15; 118(3):135-41. PMID: 19961935.
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    19. Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG. Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Cardiovasc Res. 2009 Nov 01; 84(2):209-17. PMID: 19546173.
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    20. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. PMID: 19436108.
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    21. Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG. Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. Hypertension. 2009 Mar; 53(3):549-55. PMID: 19139378.
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    22. Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG. Expression of the vitamin d receptor is increased in the hypertrophic heart. Hypertension. 2008 Dec; 52(6):1106-12. PMID: 18936343.
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    23. Glenn DJ, Gardner DG. Lipids and the heart: neither feast nor famine. Hypertension. 2007 Sep; 50(3):463-4. PMID: 17664386.
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    24. Chen S, Olsen K, Grigsby C, Gardner DG. Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells. Kidney Int. 2007 Aug; 72(3):300-6. PMID: 17440494.
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    25. Gardner DG, Chen S, Glenn DJ, Grigsby CL. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension. 2007 Mar; 49(3):419-26. PMID: 17283251.
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    26. David Gardner, Songcang Chen, Dolkun Rahmutula, Feng Wang, Keith Olsen. Molecular aspects of the natriuretic peptide system. Molecular Mechanisms in Hypertension. 2006 Apr 19; 199-209.
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    27. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Neurocrit Care. 2006; 5(3):180-5. PMID: 17290085.
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    28. Chen S, Qiong Y, Gardner DG. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006 Feb; 47(2):252-8. PMID: 16365184.
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    29. Rahmutula D, Gardner DG. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology. 2005 Nov; 146(11):4968-74. PMID: 16109786.
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    30. Chen S, Nakamura K, Gardner DG. 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30; 128(3):197-202. PMID: 15837528.
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    31. Chen S, Ni XP, Humphreys MH, Gardner DG. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. PMID: 15590756.
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    32. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E125-32. PMID: 15367398.
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    33. Rahmutula D, Cui J, Chen S, Gardner DG. Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1. Hypertension. 2004 Sep; 44(3):283-8. PMID: 15262909.
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    34. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. PMID: 15007040.
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    35. Chen S, Gardner DG. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem. 2004 Apr 02; 279(14):13755-63. PMID: 14742443.
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    36. Anderson HD, Wang F, Gardner DG. Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004 Mar 05; 279(10):9287-97. PMID: 14645255.
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    37. Gardner DG. Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab. 2003 Nov; 14(9):411-6. PMID: 14580760.
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    38. Anderson HD, Rahmutula D, Gardner DG. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004 Jan 09; 279(2):963-9. PMID: 14581470.
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    39. Liang F, Wang F, Zhang S, Gardner DG. Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology. 2003 Sep; 144(9):4187-94. PMID: 12933694.
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    40. Gardner DG. Brain natriuretic peptide: a marker for subclinical cardiovascular disease? Am J Med. 2003 Mar; 114(4):329-30. PMID: 12681464.
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    41. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21; 92(3):300-7. PMID: 12595342.
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    42. Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG. Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. J Biol Chem. 2003 Apr 25; 278(17):15073-83. PMID: 12562779.
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    43. Ye Q, Chen S, Gardner DG. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Hypertension. 2003 Mar; 41(3 Pt 2):675-81. PMID: 12623978.
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    44. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 06; 277(36):32498-504. PMID: 12082097.
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    45. Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC. Thyroid hormone export varies among primary cells and appears to differ from hormone uptake. Endocrinology. 2002 Feb; 143(2):476-83. PMID: 11796501.
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    46. Gardner DG. Manipulating the renin-angiotensin system: more than we bargained for? Am J Med. 2002 Feb 01; 112(2):152-3. PMID: 11835956.
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    47. Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D. Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes. Cell Mol Biol Lett. 2002; 7(2):323-9. PMID: 12097978.
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    48. Chen S, Gardner DG. Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK. J Biol Chem. 2002 Feb 22; 277(8):6037-43. PMID: 11744737.
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    49. Liang F, Kovacic-Milivojevic B, Chen S, Cui J, Roediger F, Intengan H, Gardner DG. Signaling mechanisms underlying strain-dependent brain natriuretic peptide gene transcription. Can J Physiol Pharmacol. 2001 Aug; 79(8):640-5. PMID: 11558672.
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    50. Kovacic-Milivojevic B, Roediger F, Almeida EA, Damsky CH, Gardner DG, Ilic D. Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy. Mol Biol Cell. 2001 Aug; 12(8):2290-307. PMID: 11514617.
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    51. Gardner DG. Hypercalcemia and sarcoidosis--another piece of the puzzle falls into place. Am J Med. 2001 Jun 15; 110(9):736-7. PMID: 11403760.
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    52. Ni XP, Safai M, Gardner DG, Humphreys MH. Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation. Kidney Int. 2001 Apr; 59(4):1264-73. PMID: 11260387.
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    53. Liang F, Schaufele F, Gardner DG. Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription. J Biol Chem. 2001 Jan 12; 276(2):1516-22. PMID: 11022037.
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    54. Liang F, Atakilit A, Gardner DG. Integrin dependence of brain natriuretic peptide gene promoter activation by mechanical strain. J Biol Chem. 2000 Jul 07; 275(27):20355-60. PMID: 10764770.
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    55. Chen S, Cui J, Nakamura K, Ribeiro RC, West BL, Gardner DG. Coactivator-vitamin D receptor interactions mediate inhibition of the atrial natriuretic peptide promoter. J Biol Chem. 2000 May 19; 275(20):15039-48. PMID: 10809746.
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    56. Liang F, Lu S, Gardner DG. Endothelin-dependent and -independent components of strain-activated brain natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase. Hypertension. 2000 Jan; 35(1 Pt 2):188-92. PMID: 10642296.
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    57. Chen S, Garami M, Gardner DG. Doxorubicin selectively inhibits brain versus atrial natriuretic peptide gene expression in cultured neonatal rat myocytes. Hypertension. 1999 Dec; 34(6):1223-31. PMID: 10601122.
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    58. Liang F, Gardner DG. Mechanical strain activates BNP gene transcription through a p38/NF-kappaB-dependent mechanism. J Clin Invest. 1999 Dec; 104(11):1603-12. PMID: 10587524.
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    59. Chen S, Costa CH, Nakamura K, Ribeiro RC, Gardner DG. Vitamin D-dependent suppression of human atrial natriuretic peptide gene promoter activity requires heterodimer assembly. J Biol Chem. 1999 Apr 16; 274(16):11260-6. PMID: 10196214.
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    60. Liang F, Schaufele F, Gardner DG. Sp1 dependence of natriuretic peptide receptor A gene transcription in rat aortic smooth muscle cells. Endocrinology. 1999 Apr; 140(4):1695-701. PMID: 10098505.
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    61. Faquan Liang, Fred Schaufele, David G. Gardner. Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells 1. Endocrinology. 1999 Apr 1; 140(4):1695-1701.
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    62. David G. Gardner, Branka Kovacic-Milivojevic, Faquan Liang, Songcang Chen. Natriuretic Peptides and the Heart. Hormones and the Heart in Health and Disease. 1999 Jan 1; 1-20.
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    63. Gardner DG, Chen S. Retinoids and cell growth in the cardiovascular system. Life Sci. 1999; 65(16):1607-13. PMID: 10573178.
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    64. Kovacic B, Ilic D, Damsky CH, Gardner DG. c-Src activation plays a role in endothelin-dependent hypertrophy of the cardiac myocyte. J Biol Chem. 1998 Dec 25; 273(52):35185-93. PMID: 9857056.
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    65. Kurtz TW, Gardner DG. Transcription-modulating drugs: a new frontier in the treatment of essential hypertension. Hypertension. 1998 Sep; 32(3):380-6. PMID: 9740599.
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    66. Chen S, Gardner DG. Retinoic acid uses divergent mechanisms to activate or suppress mitogenesis in rat aortic smooth muscle cells. J Clin Invest. 1998 Aug 15; 102(4):653-62. PMID: 9710432.
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    67. Levin ER, Gardner DG, Samson WK. Natriuretic peptides. N Engl J Med. 1998 Jul 30; 339(5):321-8. PMID: 9682046.
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    68. Cao L, Chen SC, Cheng T, Humphreys MH, Gardner DG. Ligand-dependent regulation of NPR-A gene expression in inner medullary collecting duct cells. Am J Physiol. 1998 07; 275(1):F119-25. PMID: 9689013.
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    69. Liang F, Gardner DG. Autocrine/paracrine determinants of strain-activated brain natriuretic peptide gene expression in cultured cardiac myocytes. J Biol Chem. 1998 Jun 05; 273(23):14612-9. PMID: 9603978.
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    70. Chen S, Su J, Wu K, Hu W, Gardner DG, Chen D. Early captopril treatment prevents hypertrophydependent gene expression in hearts of SHR. Am J Physiol. 1998 06; 274(6):R1511-7. PMID: 9608003.
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    71. Chen S, Wu J, Hsieh JC, Whitfield GK, Jurutka PW, Haussler MR, Gardner DG. Suppression of ANP gene transcription by liganded vitamin D receptor: involvement of specific receptor domains. Hypertension. 1998 Jun; 31(6):1338-42. PMID: 9622151.
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    72. Liang F, Wu J, Garami M, Gardner DG. Mechanical strain increases expression of the brain natriuretic peptide gene in rat cardiac myocytes. J Biol Chem. 1997 Oct 31; 272(44):28050-6. PMID: 9346958.
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    73. Kovacic-Milivojevic B, Zlock DW, Gardner DG. Ras inhibits Jun-activated human atrial natriuretic peptide gene transcription in cultured ventricular myocytes. Circ Res. 1997 Apr; 80(4):580-8. PMID: 9118490.
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    74. David G. Gardner, Jianming Wu, Branka Kovacic-Milivojevic. Cellular and Molecular Aspects of the A-Type Natriuretic Peptide. Natriuretic Peptides in Health and Disease. 1997 Jan 1; 71-94.
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    75. Gardner DG. Recent advances in multiple endocrine neoplasia syndromes. Adv Intern Med. 1997; 42:597-627. PMID: 9048131.
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    76. Zlock DW, Cao L, Wu J, Gardner DG. Thrombin inhibits atrial natriuretic peptide receptor activity in cultured bovine endothelial cells. Hypertension. 1997 Jan; 29(1 Pt 1):83-90. PMID: 9039085.
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    77. Ni X, Cheng Y, Cao L, Gardner DG, Humphreys MH. Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation. J Am Soc Nephrol. 1996 Oct; 7(10):2110-8. PMID: 8915970.
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    78. Garami M, Gardner DG. An E-box motif conveys inhibitory activity on the atrial natriuretic peptide gene. Hypertension. 1996 Aug; 28(2):315-9. PMID: 8707400.
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    79. Wu J, Garami M, Cheng T, Gardner DG. 1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. J Clin Invest. 1996 Apr 01; 97(7):1577-88. PMID: 8601621.
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    80. Kovacic-Milivojevic B, Wong VS, Gardner DG. Selective regulation of the atrial natriuretic peptide gene by individual components of the activator protein-1 complex. Endocrinology. 1996 Mar; 137(3):1108-17. PMID: 8603581.
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    81. LaPointe MC, Wu G, Garami M, Yang XP, Gardner DG. Tissue-specific expression of the human brain natriuretic peptide gene in cardiac myocytes. Hypertension. 1996 Mar; 27(3 Pt 2):715-22. PMID: 8613230.
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    82. Cao L, Wu J, Gardner DG. Atrial natriuretic peptide suppresses the transcription of its guanylyl cyclase-linked receptor. J Biol Chem. 1995 Oct 20; 270(42):24891-7. PMID: 7559613.
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    83. Wu J, Garami M, Cao L, Li Q, Gardner DG. 1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am J Physiol. 1995 Jun; 268(6 Pt 1):E1108-13. PMID: 7611385.
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    84. Valentin JP, Qiu C, Wiedemann E, Gardner DG, Humphreys MH. Modulation of ANP-dependent effects of endothelin by inhibitors of neutral endopeptidase and cGMP phosphodiesterase. J Pharmacol Exp Ther. 1995 May; 273(2):744-52. PMID: 7752077.
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    85. Kovacic-Milivojevic B, Gardner DG. Fra-1, a Fos gene family member that activates atrial natriuretic peptide gene transcription. Hypertension. 1995 Apr; 25(4 Pt 2):679-82. PMID: 7721415.
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    86. Cao L, Gardner DG. Natriuretic peptides inhibit DNA synthesis in cardiac fibroblasts. Hypertension. 1995 Feb; 25(2):227-34. PMID: 7843772.
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    87. Cao L, Zlock DW, Gardner DG. Differential regulation of natriuretic peptide receptor activity in vascular cells. Hypertension. 1994 Sep; 24(3):329-38. PMID: 8082940.
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    88. Gardner DG. Molecular biology of the natriuretic peptides. Trends Cardiovasc Med. 1994 Jul-Aug; 4(4):159-65. PMID: 21244881.
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    89. Li Q, Gardner DG. Negative regulation of the human atrial natriuretic peptide gene by 1,25-dihydroxyvitamin D3. J Biol Chem. 1994 Feb 18; 269(7):4934-9. PMID: 8106467.
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    90. Gardner DG. Designer natriuretic peptides. J Clin Invest. 1993 Oct; 92(4):1606-7. PMID: 8408614.
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    91. Kovacic-Milivojevic B, Gardner DG. Regulation of the human atrial natriuretic peptide gene in atrial cardiocytes by the transcription factor AP-1. Am J Hypertens. 1993 Apr; 6(4):258-63. PMID: 8507443.
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    92. Humphreys MH, Valentin JP, Qiu C, Ying WZ, Muldowney WP, Gardner DG. Underfill and overflow revisited: mechanisms of nephrotic edema. Trans Am Clin Climatol Assoc. 1993; 104:47-59; discussion 59-60. PMID: 1343447.
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    93. Valentin JP, Qiu C, Muldowney WP, Ying WZ, Gardner DG, Humphreys MH. Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome. J Clin Invest. 1992 Oct; 90(4):1302-12. PMID: 1328296.
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    94. Gardner DG, Wirtz H, Dobbs LG. Stretch-dependent regulation of atrial peptide synthesis and secretion in cultured atrial cardiocytes. Am J Physiol. 1992 Aug; 263(2 Pt 1):E239-44. PMID: 1381150.
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    95. Gardner DG, Camargo MJ, Behringer RR, Brinster RL, Baxter JD, Atlas SA, Laragh JH, Deschepper CF. Atrial natriuretic peptide synthesis in atrial tumors of transgenic mice. Am J Physiol. 1992 Apr; 262(4 Pt 1):E524-31. PMID: 1373564.
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    96. Valentin JP, Qiu CB, Wiedemann E, Gardner D, Humphreys MH. Inhibition of neutral endopeptidase amplifies the effects of endogenous atrial natriuretic peptide on blood pressure and fluid partition. Am J Hypertens. 1992 Feb; 5(2):88-91. PMID: 1532317.
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    97. Kovacic-Milivojevic B, Gardner DG. Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos. Mol Cell Biol. 1992 Jan; 12(1):292-301. PMID: 1530876.
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    98. Kovacic-Milivojevic B, Schultz HD, Gardner DG. Arachidonic acid metabolites regulate the secretion of atrial natriuretic peptide in cultured rat atrial cardiocytes. Can J Physiol Pharmacol. 1991 Oct; 69(10):1493-9. PMID: 1723348.
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    99. Wu JP, Kovacic-Milivojevic B, Lapointe MC, Nakamura K, Gardner DG. Cis-active determinants of cardiac-specific expression in the human atrial natriuretic peptide gene. Mol Endocrinol. 1991 Sep; 5(9):1311-22. PMID: 1837591.
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    100. Gardner DG, Newman ED, Nakamura KK, Nguyen KP. Endothelin increases the synthesis and secretion of atrial natriuretic peptide in neonatal rat cardiocytes. Am J Physiol. 1991 Aug; 261(2 Pt 1):E177-82. PMID: 1831328.
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    101. Valentin JP, Gardner DG, Ribstein J, Mimran A, Humphreys MH. [Extravascular transfer of fluids and proteins induced by endothelin in the binephrectomized rat]. Arch Mal Coeur Vaiss. 1991 Aug; 84(8):1159-62. PMID: 1835358.
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    102. Steele MK, Gardner DG, Xie PL, Schultz HD. Interactions between ANP and ANG II in regulating blood pressure and sympathetic outflow. Am J Physiol. 1991 Jun; 260(6 Pt 2):R1145-51. PMID: 1829337.
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    103. Valentin JP, Gardner DG, Wiedemann E, Humphreys MH. Modulation of endothelin effects on blood pressure and hematocrit by atrial natriuretic peptide. Hypertension. 1991 Jun; 17(6 Pt 2):864-9. PMID: 1828459.
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    104. Deschepper CF, Nguyen KP, Lapointe MC, Zahs KR, Gardner DG. Production and differential endocrine regulation of atrial natriuretic peptide in neuron-enriched primary cultures. Endocrinology. 1991 Jan; 128(1):5-12. PMID: 1702703.
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    105. Gardner DG. Transgenic animals in hypertension research. New approaches to old questions. Hypertension. 1990 Sep; 16(3):308-10. PMID: 2144262.
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    106. Gardner DG, Schultz HD. Prostaglandins regulate the synthesis and secretion of the atrial natriuretic peptide. J Clin Invest. 1990 Jul; 86(1):52-9. PMID: 2142168.
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    107. Schultz HD, Steele MK, Gardner DG. Central administration of atrial peptide decreases sympathetic outflow in rats. Am J Physiol. 1990 May; 258(5 Pt 2):R1250-6. PMID: 2140027.
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    108. LaPointe MC, Deschepper CF, Wu JP, Gardner DG. Extracellular calcium regulates expression of the gene for atrial natriuretic factor. Hypertension. 1990 Jan; 15(1):20-8. PMID: 1688546.
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    109. Rubinstein I, Reiss TF, Gardner DG, Liu J, Bigby BG, Boushey HA. Effect of exercise, hyperpnea, and bronchoconstriction on plasma atrial natriuretic peptide. J Appl Physiol (1985). 1989 Dec; 67(6):2565-70. PMID: 2532642.
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    110. Gardner DG, Hedges BK, Wu J, LaPointe MC, Deschepper CF. Expression of the atrial natriuretic peptide gene in human fetal heart. J Clin Endocrinol Metab. 1989 Oct; 69(4):729-37. PMID: 2528567.
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    111. Wu J, LaPointe MC, West BL, Gardner DG. Tissue-specific determinants of human atrial natriuretic factor gene expression in cardiac tissue. J Biol Chem. 1989 Apr 15; 264(11):6472-9. PMID: 2522932.
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    112. Wong KR, Xie MH, Shi LB, Liu FY, Huang CL, Gardner DG, Cogan MG. Urinary cGMP as biological marker of the renal activity of atrial natriuretic factor. Am J Physiol. 1988 Dec; 255(6 Pt 2):F1220-4. PMID: 2849318.
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    113. Gardner DG, Wu JP, LaPointe MC, Hedges BK, Deschepper CF. Expression of the gene for the atrial natriuretic peptide in cardiac myocytes in vitro. Cardiovasc Drugs Ther. 1988 Nov; 2(4):479-86. PMID: 2979001.
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    114. Gardner DG, Gertz BJ, Deschepper CF, Kim DY. Gene for the rat atrial natriuretic peptide is regulated by glucocorticoids in vitro. J Clin Invest. 1988 Oct; 82(4):1275-81. PMID: 2971674.
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    115. Gardner DG, Cathala G, Lan NY, David-Inouye Y, Baxter JD. Processing of the primary transcript for the rat growth hormone gene in vivo. DNA. 1988 Oct; 7(8):537-44. PMID: 3180994.
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    116. Wu JP, Deschepper CF, Gardner DG. Perinatal expression of the atrial natriuretic factor gene in rat cardiac tissue. Am J Physiol. 1988 Sep; 255(3 Pt 1):E388-96. PMID: 2971324.
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    117. LaPointe MC, Wu JP, Greenberg B, Gardner DG. Upstream sequences confer atrial-specific expression on the human atrial natriuretic factor gene. J Biol Chem. 1988 Jul 05; 263(19):9075-8. PMID: 2967819.
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    118. Schultz HD, Gardner DG, Deschepper CF, Coleridge HM, Coleridge JC. Vagal C-fiber blockade abolishes sympathetic inhibition by atrial natriuretic factor. Am J Physiol. 1988 Jul; 255(1 Pt 2):R6-13. PMID: 2969196.
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    119. Gertz BJ, Gardner DG, Baxter JD. Glucocorticoid control of rat growth hormone gene expression: effect on cytoplasmic messenger ribonucleic acid production and degradation. Mol Endocrinol. 1987 Dec; 1(12):933-41. PMID: 3153471.
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    120. Isaacs RE, Gardner DG, Baxter JD. Insulin regulation of rat growth hormone gene expression. Endocrinology. 1987 May; 120(5):2022-8. PMID: 3552628.
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    121. Gardner DG, Vlasuk GP, Baxter JD, Fiddes JC, Lewicki JA. Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat. Proc Natl Acad Sci U S A. 1987 Apr; 84(8):2175-9. PMID: 2951736.
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    122. Gardner DG, Gertz BJ, Hane S. Thyroid hormone increases rat atrial natriuretic peptide messenger ribonucleic acid accumulation in vivo and in vitro. Mol Endocrinol. 1987 Mar; 1(3):260-5. PMID: 2969452.
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    123. Gardner DG, Deschepper CF, Baxter JD. The gene for the atrial natriuretic factor is expressed in the aortic arch. Hypertension. 1987 Jan; 9(1):103-6. PMID: 2947852.
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    124. Metzler CH, Gardner DG, Keil LC, Baxter JD, Ramsay DJ. Increased synthesis and release of atrial peptide during DOCA escape in conscious dogs. Am J Physiol. 1987 Jan; 252(1 Pt 2):R188-92. PMID: 2949629.
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    125. Gardner DG, Hane S, Trachewsky D, Schenk D, Baxter JD. Atrial natriuretic peptide mRNA is regulated by glucocorticoids in vivo. Biochem Biophys Res Commun. 1986 Sep 30; 139(3):1047-54. PMID: 2945558.
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    126. Gardner DG, Deschepper CF, Ganong WF, Hane S, Fiddes J, Baxter JD, Lewicki J. Extra-atrial expression of the gene for atrial natriuretic factor. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6697-701. PMID: 2428040.
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    127. Slater EP, Anderson T, Cattini P, Isaacs R, Birnbaum MJ, Gardner DG, Eberhardt NL, Baxter JD. Mechanisms of glucocorticoid hormone action. Adv Exp Med Biol. 1986; 196:67-80. PMID: 3012984.
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    128. Thatcher JG, Gardner DG, Brown EM. Adenosine 3',5'-monophosphate-dependent protein kinase in supernatants from dispersed bovine parathyroid cells. Endocrinology. 1982 Apr; 110(4):1367-73. PMID: 6277602.
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    129. Gardner DG, Baxter JD. Recombinant DNA. Am J Med. 1982 Apr; 72(4):551-3. PMID: 6951412.
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    130. Norman L. Eberhardt, Mark Selby, Guy Cathala, Michael Karin, Arthur Gutierrez-Hartmann, Synthia H. Mellon, Nancy C. Lan, David Gardner, John D. Baxter. THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION11This work was supported by NIH Grants AM19997 and AM18878 and NSF Grant 8004735. Gene Regulation. 1982 Jan 1; 235-251.
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    131. Gardner DG, Brown EM, Aurbach GD. Sodium nitroprusside inhibition of parathyroid hormone release is not mediated through cyclic GMP. Metabolism. 1981 Dec; 30(12):1179-84. PMID: 6118808.
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    132. Brown EM, Adragna N, Gardner DG. Effect of potassium on PTH secretion from dispersed bovine parathyroid cells. J Clin Endocrinol Metab. 1981 Dec; 53(6):1304-6. PMID: 7298807.
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    133. Gardner DG, Brown EM, Attie MF, Aurbach GD. Effects of prostaglandins on adenosine 3',5'-monophosphate content and adenylate cyclase activity in dispersed bovine parathyroid cells. Endocrinology. 1981 Nov; 109(5):1545-51. PMID: 6271534.
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    134. Attie MF, Brown EM, Gardner DG, Spiegel AM, Aurbach GD. Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion. Endocrinology. 1980 Dec; 107(6):1776-81. PMID: 7428692.
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    135. Gardner DG, Brown EM, Attie MF, Aurbach GD. Prostaglandin-mediated stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed human parathyroid cells. J Clin Endocrinol Metab. 1980 Jul; 51(1):20-5. PMID: 6247364.
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    136. Marx SJ, Spiegel AM, Sharp ME, Brown EM, Gardner DG, Downs RW, Attie MF, Stock JL. Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. J Clin Endocrinol Metab. 1980 Mar; 50(3):546-8. PMID: 6244324.
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    137. Brown EM, Gardner DG, Aurbach GD. Effects of the calcium ionophore A23187 on dispersed bovine parathyroid cells. Endocrinology. 1980 Jan; 106(1):133-8. PMID: 6243093.
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    138. Gardner DG, Brown EM, Aurbach GD. Inhibition of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release by sodium nitroprusside. Endocrinology. 1979 Aug; 105(2):360-6. PMID: 222571.
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    139. Brown EM, Gardner DG, Brennan MF, Marx SJ, Spiegel AM, Attie MF, Downs RW, Doppman JL, Aurbach CD. Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells. Am J Med. 1979 Jun; 66(6):923-31. PMID: 453225.
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    140. Brown EM, Gardner DG, Windeck RA, Hurwitz S, Brennan MF, Aurbach GD. Beta-adrenergically stimulated adenosine 3',5'-monophosphate accumulation in and parathyroid hormone release from dispersed human parathyroid cells. J Clin Endocrinol Metab. 1979 Apr; 48(4):618-26. PMID: 219001.
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    141. Brown EM, Broadus AE, Brennan MF, Gardner DG, Marx SJ, Spiegel AM, Downs RW, Attie M, Aurbach GD. Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism. J Clin Endocrinol Metab. 1979 Apr; 48(4):604-10. PMID: 429506.
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    142. Brown EM, Brennan MF, Broadus AE, Marx SJ, Gardner DG, Spiegel AM, Downs RW, Attie MF, Aurbach GD. Human parathyroid autografts: comparison of function in vivo and in vitro. J Clin Endocrinol Metab. 1979 Apr; 48(4):648-54. PMID: 219003.
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    143. Gardner DG, Brown EM, Windeck R, Aurbach GD. Prostaglandin F2alpha inhibits 3',3'-adenosine monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1979 Jan; 104(1):1-7. PMID: 221165.
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    144. Brown EM, Gardner DG, Windeck RA, Aurbach GD. Cholera toxin stimulates 3',5'-adenosine monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1979 Jan; 104(1):218-25. PMID: 221168.
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    145. Windeck R, Brown EM, Gardner DG, Aurbach GD. Effect of gastrointestinal hormones on isolated bovine parathyroid cells. Endocrinology. 1978 Dec; 103(6):2020-6. PMID: 218798.
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    146. Brown EM, Gardner DG, Windeck RA, Aurbach GD. Relationship of intracellular 3',5'-adenosine monophosphate accumulation to parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1978 Dec; 103(6):2323-33. PMID: 85548.
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    147. Marx SJ, Spiegel AM, Brown EM, Gardner DG, Downs RW, Attie M, Hamstra AJ, DeLuca HF. A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab. 1978 Dec; 47(6):1303-10. PMID: 233695.
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    148. Marx SJ, Spiegel AM, Brown EM, Windeck R, Gardner DG, Downs RW, Attie M, Aurbach GD. Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. J Clin Endocrinol Metab. 1978 Dec; 47(6):1190-7. PMID: 233692.
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    149. Gardner DG, Brown EM, Windeck R, Aurbach GD. Prostaglandin E2 stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed bovine parathyroid cells. Endocrinology. 1978 Aug; 103(2):577-82. PMID: 217651.
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    150. Marx SJ, Spiegel AM, Brown EM, Koehler JO, Gardner DG, Brennan MF, Aurbach GD. Divalent cation metabolism. Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. Am J Med. 1978 Aug; 65(2):235-42. PMID: 686009.
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    151. Brown EM, Brennan MF, Hurwitz S, Windeck R, Marx SJ, Spiegel AM, Koehler JO, Gardner DG, Aurbach GD. Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia. J Clin Endocrinol Metab. 1978 Feb; 46(2):267-75. PMID: 750604.
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    152. Gardner DG, Wittliff JL. Characterization of a distinct glucocorticoid-binding protein in the lactating mammary gland of the rat. Biochim Biophys Acta. 1973 Oct 05; 320(3):617-27. PMID: 4752279.
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    153. Gardner DG, Wittliff JL. Specific estrogen receptors in the lactating mammary gland of the rat. Biochemistry. 1973 Jul 31; 12(16):3090-6. PMID: 4354253.
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    154. Gardner DG, Wittliff JL. Demonstration of a glucocorticoid hormone-receptor complex in the cytoplasm of a hormone-responsive tumour. Br J Cancer. 1973 Jun; 27(6):441-4. PMID: 4352788.
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    155. Wittliff JL, Gardner DG, Battema WL, Gilbert PJ. Specific estrogen-receptors in the neoplastic and lactating mammary gland of the rat. Biochem Biophys Res Commun. 1972 Jul 11; 48(1):119-25. PMID: 5064953.
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    156. GARDNER DG. Resolution of multi-component exponential decay curves using Fourier transforms. Ann N Y Acad Sci. 1963 May 10; 108:195-203. PMID: 13946538.
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