David Gardner, MD

Title(s)Professor , Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #1131
San Francisco CA 94143
Phone415-476-1364
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    Collapse Research Activities and Funding
    Regulation of ANP Receptor Activity in Vascular Cells
    NIH R01HL045637Jul 1, 1992 - Feb 28, 2013
    Role: Principal Investigator
    EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    NIH R01HL035753Sep 30, 1985 - Jun 30, 2004
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH S07RR005890Apr 1, 1983 - Mar 31, 1991
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. PMID: 27217488; PMCID: PMC5001188.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    2. Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. J Steroid Biochem Mol Biol. 2016 11; 164:292-298. Glenn DJ, Cardema MC, Gardner DG. PMID: 26429397.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    3. Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance. J Steroid Biochem Mol Biol. 2016 11; 164:281-286. Ni W, Glenn DJ, Gardner DG. PMID: 26369613; PMCID: PMC4788578.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    4. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS One. 2015; 10(7):e0131539. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. PMID: 26134669; PMCID: PMC4489761.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    5. Cardiac steatosis potentiates angiotensin II effects in the heart. Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H339-50. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. PMID: 25485904; PMCID: PMC4329483.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    6. Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Hypertension. 2014 Dec; 64(6):1290-8. Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG. PMID: 25201890; PMCID: PMC4430199.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    7. Vitamin D and the heart. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 01; 305(9):R969-77. Gardner DG, Chen S, Glenn DJ. PMID: 24026071; PMCID: PMC3840320.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    8. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. PMID: 23682710; PMCID: PMC3717170.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    9. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. PMID: 23337142.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart. J Steroid Biochem Mol Biol. 2013 Jul; 136:150-5. Chen S, Gardner DG. PMID: 22989481.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer. 2012 Aug; 19(4):497-508. Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC. PMID: 22645228.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    12. Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F141-9. Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E. PMID: 21957179.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    13. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011 Oct 25; 124(17):1838-47. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21947295; PMCID: PMC4160312.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    14. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21220706; PMCID: PMC3322545.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    15. Chapter 31 Vitamin D and the Cardiovascular System. Vitamin D. 2011 Jan 1; 541-563. Gardner GD, Chen CS, Glenn GD, Ni NW. .
      View in: Publisher Site   Mentions:
    16. A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. J Steroid Biochem Mol Biol. 2010 Nov; 122(5):326-32. Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG. PMID: 20813185; PMCID: PMC4143149.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. J Steroid Biochem Mol Biol. 2010 Feb 15; 118(3):135-41. Chen S, Law CS, Gardner DG. PMID: 19961935; PMCID: PMC2830853.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    18. Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Cardiovasc Res. 2009 Nov 01; 84(2):209-17. Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG. PMID: 19546173; PMCID: PMC2761198.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. PMID: 19436108; PMCID: PMC2689130.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    20. Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. Hypertension. 2009 Mar; 53(3):549-55. Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG. PMID: 19139378; PMCID: PMC2710878.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. Expression of the vitamin d receptor is increased in the hypertrophic heart. Hypertension. 2008 Dec; 52(6):1106-12. Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG. PMID: 18936343; PMCID: PMC2690395.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    22. Lipids and the heart: neither feast nor famine. Hypertension. 2007 Sep; 50(3):463-4. Glenn DJ, Gardner DG. PMID: 17664386.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension. 2007 Mar; 49(3):419-26. Gardner DG, Chen S, Glenn DJ, Grigsby CL. PMID: 17283251.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    24. Molecular aspects of the natriuretic peptide system. Molecular Mechanisms in Hypertension. 2006 Apr 19; 199-209. Gardner GD, Chen CS, Rahmutula RD, Wang WF, Olsen OK. .
      View in: Publisher Site   Mentions:
    25. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Neurocrit Care. 2006; 5(3):180-5. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. PMID: 17290085.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    26. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006 Feb; 47(2):252-8. Chen S, Qiong Y, Gardner DG. PMID: 16365184.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    27. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology. 2005 Nov; 146(11):4968-74. Rahmutula D, Gardner DG. PMID: 16109786.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30; 128(3):197-202. Chen S, Nakamura K, Gardner DG. PMID: 15837528.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    29. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. Chen S, Ni XP, Humphreys MH, Gardner DG. PMID: 15590756.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E125-32. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. PMID: 15367398.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    31. Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1. Hypertension. 2004 Sep; 44(3):283-8. Rahmutula D, Cui J, Chen S, Gardner DG. PMID: 15262909.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    32. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. PMID: 15007040.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    33. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem. 2004 Apr 02; 279(14):13755-63. Chen S, Gardner DG. PMID: 14742443.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004 Mar 05; 279(10):9287-97. Anderson HD, Wang F, Gardner DG. PMID: 14645255.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab. 2003 Nov; 14(9):411-6. Gardner DG. PMID: 14580760.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    36. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004 Jan 09; 279(2):963-9. Anderson HD, Rahmutula D, Gardner DG. PMID: 14581470.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    37. Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology. 2003 Sep; 144(9):4187-94. Liang F, Wang F, Zhang S, Gardner DG. PMID: 12933694.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    38. Brain natriuretic peptide: a marker for subclinical cardiovascular disease? Am J Med. 2003 Mar; 114(4):329-30. Gardner DG. PMID: 12681464.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21; 92(3):300-7. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. PMID: 12595342.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    40. Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. J Biol Chem. 2003 Apr 25; 278(17):15073-83. Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG. PMID: 12562779.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    41. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Hypertension. 2003 Mar; 41(3 Pt 2):675-81. Ye Q, Chen S, Gardner DG. PMID: 12623978.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    42. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 06; 277(36):32498-504. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. PMID: 12082097.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Thyroid hormone export varies among primary cells and appears to differ from hormone uptake. Endocrinology. 2002 Feb; 143(2):476-83. Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC. PMID: 11796501.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    44. Manipulating the renin-angiotensin system: more than we bargained for? Am J Med. 2002 Feb 01; 112(2):152-3. Gardner DG. PMID: 11835956.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Thyroid Hormone Export Varies among Primary Cells and Appears to Differ from Hormone Uptake. Endocrinology. 2002 Feb 1; 143(2):476-483. Neves NF, Cavalieri CR, Simeoni SL, Gardner GD, Baxter BJ, Scharschmidt SB, Lomri LN, Ribeiro RR. .
      View in: Publisher Site   Mentions:
    46. Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes. Cell Mol Biol Lett. 2002; 7(2):323-9. Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D. PMID: 12097978.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK. J Biol Chem. 2002 Feb 22; 277(8):6037-43. Chen S, Gardner DG. PMID: 11744737.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    48. Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells 1. Endocrinology. 1999 Apr 1; 140(4):1695-1701. Liang LF, Schaufele SF, Gardner GD. .
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    49. Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells*. Endocrinology. 1999 Apr 1; 140(4):1695-1701. Liang LF, Schaufele SF, Gardner GD. .
      View in: Publisher Site   Mentions:
    50. Natriuretic Peptides and the Heart. Hormones and the Heart in Health and Disease. 1999 Jan 1; 1-20. Gardner GD, Kovacic-Milivojevic KB, Liang LF, Chen CS. .
      View in: Publisher Site   Mentions:
    51. Cellular and Molecular Aspects of the A-Type Natriuretic Peptide. Natriuretic Peptides in Health and Disease. 1997 Jan 1; 71-94. Gardner GD, Wu WJ, Kovacic-Milivojevic KB. .
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    52. Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos. Molecular and Cellular Biology. 1992 Jan 1; 12(1):292-301. Kovacic-Milivojevic KB, Gardner GD. .
      View in: Publisher Site   Mentions:
    53. Divergent Regulation of the Human Atrial Natriuretic Peptide Gene by c-jun and c-fos. Molecular and Cellular Biology. 1992 Jan 1; 12(1):292-301. Kovacic-Milivojevic KB, Gardner GD. .
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    54. 42 Extravascular shift of fluid and albumin induced by endothelin in binephrectomized rats. Journal of Hypertension. 1991 Sep 1; 9(9):885. Valentin VJ, Gardner GD, Ribstein RJ, Mimran MA, Humphreys HM. .
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    55. Atrial Natriuretic Peptide. Nature Biotechnology. 1988 May 1; 6(5):529-546. Baxter BJ, Lewicki LJ, Gardner GD. .
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    56. THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION11This work was supported by NIH Grants AM19997 and AM18878 and NSF Grant 8004735. Gene Regulation. 1982 Jan 1; 235-251. Eberhardt EN, Selby SM, Cathala CG, Karin KM, Gutierrez-Hartmann GA, Mellon MS, Lan LN, Gardner GD, Baxter BJ. .
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