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David Gardner, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-1364
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    Collapse Research 
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    Regulation of ANP Receptor Activity in Vascular Cells
    NIH/NHLBI R01HL045637Jul 1, 1992 - Nov 30, 2011
    Role: Principal Investigator
    EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    NIH/NHLBI R01HL035753Sep 30, 1985 - Sep 29, 1994
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH/NCRR S07RR005890Apr 1, 1983 - Mar 31, 1991
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. PMID: 27217488.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    2. Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. J Steroid Biochem Mol Biol. 2016 11; 164:292-298. Glenn DJ, Cardema MC, Gardner DG. PMID: 26429397.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    3. Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance. J Steroid Biochem Mol Biol. 2016 11; 164:281-286. Ni W, Glenn DJ, Gardner DG. PMID: 26369613.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS One. 2015; 10(7):e0131539. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. PMID: 26134669.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    5. Cardiac steatosis potentiates angiotensin II effects in the heart. . 2015 Feb 15; 308(4):H339-50. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. PMID: 25485904.
      View in: PubMed   Mentions:
    6. Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Hypertension. 2014 Dec; 64(6):1290-8. Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG. PMID: 25201890.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    7. Vitamin D and the heart. . 2013 Nov 01; 305(9):R969-77. Gardner DG, Chen S, Glenn DJ. PMID: 24026071.
      View in: PubMed   Mentions:
    8. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. PMID: 23682710.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    9. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. PMID: 23337142.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart. J Steroid Biochem Mol Biol. 2013 Jul; 136:150-5. Chen S, Gardner DG. PMID: 22989481.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    11. Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer. 2012 Aug; 19(4):497-508. Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC. PMID: 22645228.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F141-9. Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E. PMID: 21957179.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    13. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011 Oct 25; 124(17):1838-47. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21947295.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    14. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21220706.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    15. Chapter 31 Vitamin D and the Cardiovascular System. Vitamin D. 2011 Jan 1; 541-563. David G. Gardner, Songcang Chen, Denis J. Glenn, Wei Ni. .
      View in: Publisher Site   Mentions:
    16. A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. J Steroid Biochem Mol Biol. 2010 Nov; 122(5):326-32. Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG. PMID: 20813185.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. J Steroid Biochem Mol Biol. 2010 Feb 15; 118(3):135-41. Chen S, Law CS, Gardner DG. PMID: 19961935.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    18. Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Cardiovasc Res. 2009 Nov 01; 84(2):209-17. Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG. PMID: 19546173.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. PMID: 19436108.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    20. Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. Hypertension. 2009 Mar; 53(3):549-55. Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG. PMID: 19139378.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Expression of the vitamin d receptor is increased in the hypertrophic heart. Hypertension. 2008 Dec; 52(6):1106-12. Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG. PMID: 18936343.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    22. Lipids and the heart: neither feast nor famine. Hypertension. 2007 Sep; 50(3):463-4. Glenn DJ, Gardner DG. PMID: 17664386.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension. 2007 Mar; 49(3):419-26. Gardner DG, Chen S, Glenn DJ, Grigsby CL. PMID: 17283251.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    24. Molecular aspects of the natriuretic peptide system. Molecular Mechanisms in Hypertension. 2006 Apr 19; 199-209. David Gardner, Songcang Chen, Dolkun Rahmutula, Feng Wang, Keith Olsen. .
      View in: Publisher Site   Mentions:
    25. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Neurocrit Care. 2006; 5(3):180-5. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. PMID: 17290085.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    26. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006 Feb; 47(2):252-8. Chen S, Qiong Y, Gardner DG. PMID: 16365184.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology. 2005 Nov; 146(11):4968-74. Rahmutula D, Gardner DG. PMID: 16109786.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30; 128(3):197-202. Chen S, Nakamura K, Gardner DG. PMID: 15837528.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    29. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. Chen S, Ni XP, Humphreys MH, Gardner DG. PMID: 15590756.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    30. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E125-32. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. PMID: 15367398.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    31. Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1. Hypertension. 2004 Sep; 44(3):283-8. Rahmutula D, Cui J, Chen S, Gardner DG. PMID: 15262909.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. PMID: 15007040.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    33. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem. 2004 Apr 02; 279(14):13755-63. Chen S, Gardner DG. PMID: 14742443.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    34. Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004 Mar 05; 279(10):9287-97. Anderson HD, Wang F, Gardner DG. PMID: 14645255.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    35. Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab. 2003 Nov; 14(9):411-6. Gardner DG. PMID: 14580760.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    36. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004 Jan 09; 279(2):963-9. Anderson HD, Rahmutula D, Gardner DG. PMID: 14581470.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    37. Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology. 2003 Sep; 144(9):4187-94. Liang F, Wang F, Zhang S, Gardner DG. PMID: 12933694.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    38. Brain natriuretic peptide: a marker for subclinical cardiovascular disease? Am J Med. 2003 Mar; 114(4):329-30. Gardner DG. PMID: 12681464.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21; 92(3):300-7. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. PMID: 12595342.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    40. Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. J Biol Chem. 2003 Apr 25; 278(17):15073-83. Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG. PMID: 12562779.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    41. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Hypertension. 2003 Mar; 41(3 Pt 2):675-81. Ye Q, Chen S, Gardner DG. PMID: 12623978.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 06; 277(36):32498-504. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. PMID: 12082097.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Manipulating the renin-angiotensin system: more than we bargained for? Am J Med. 2002 Feb 01; 112(2):152-3. Gardner DG. PMID: 11835956.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Thyroid hormone export varies among primary cells and appears to differ from hormone uptake. Endocrinology. 2002 Feb; 143(2):476-83. Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC. PMID: 11796501.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    45. Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes. Cell Mol Biol Lett. 2002; 7(2):323-9. Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D. PMID: 12097978.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK. J Biol Chem. 2002 Feb 22; 277(8):6037-43. Chen S, Gardner DG. PMID: 11744737.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    47. Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells 1. Endocrinology. 1999 Apr 1; 140(4):1695-1701. Faquan Liang, Fred Schaufele, David G. Gardner. .
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    48. Natriuretic Peptides and the Heart. Hormones and the Heart in Health and Disease. 1999 Jan 1; 1-20. David G. Gardner, Branka Kovacic-Milivojevic, Faquan Liang, Songcang Chen. .
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    49. Cellular and Molecular Aspects of the A-Type Natriuretic Peptide. Natriuretic Peptides in Health and Disease. 1997 Jan 1; 71-94. David G. Gardner, Jianming Wu, Branka Kovacic-Milivojevic. .
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    50. Atrial Natriuretic Peptide. Nature Biotechnology. 1988 May 1; 6(5):529-546. John D. Baxter, John A. Lewicki, David G. Gardner. .
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    51. THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION11This work was supported by NIH Grants AM19997 and AM18878 and NSF Grant 8004735. Gene Regulation. 1982 Jan 1; 235-251. Norman L. Eberhardt, Mark Selby, Guy Cathala, Michael Karin, Arthur Gutierrez-Hartmann, Synthia H. Mellon, Nancy C. Lan, David Gardner, John D. Baxter. .
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