David Pearce, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address600 16th Street, #N272C
San Francisco CA 94158
Phone415-502-4326
ORCID ORCID Icon0000-0003-0496-3173 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1989 Medicine
    University of California, San FranciscoResidency

    Collapse Overview 
    Collapse Overview
    EDUCATION
    College: University of California, Berkeley BA (Mathematics)
    Medical School: University of Chicago, Pritzker School of Medicine, MD
    Internal Medicine Residency: Harbor-UCLA Medical Center
    Nephrology Fellowship: University of California, San Francisco

    Dr. Pearce's research focuses on understanding the cellular and molecular mechanisms underlying hormone-regulated ion transport in the kidney tubules. His lab has cloned and characterized several key regulatory proteins involved in the control of epithelial Na+ and K+ transport. Notably, SGK1 is a serine-threonine signaling kinase, which mediates the effects of multiple hormones, and is necessary for normal Na+ and K+ homeostasis. Defects in SGK1 result in pseudohypoaldosteronism (Na+ wasting and inability to excrete K+ despite high aldosterone levels).

    His group has made seminal contributions to our understanding of how the effects of SGK1 and other signaling proteins are integrated to achieve specific regulation of ion transport. Recently, his lab identified a large multiprotein complex, which integrates manifold inputs that impact on Na+ transport in kidney tubule cells. The principal goal of this basic research is to identify points of entry for treatment of diseases such as hypertension and metabolic syndrome. Already, SGK1 inhibitors are in preclinical testing for the treatment of salt sensitive hypertension.

    Dr. Pearce's research is funded by two R01's from the NIDDK, and several Foundation awards.

    Dr. Pearce is Professor of Medicine and Cellular & Molecular Pharmacology at UCSF, and Chief of Nephrology at San Francisco General Hospital, one of the core teaching hospitals affiliated with UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    GILZ Regulation of ENaC
    NIH R01DK085101Aug 1, 2009 - Jul 31, 2014
    Role: Principal Investigator
    SGK Regulation of Epithelial Sodium Transport
    NIH R01DK056695Aug 15, 2000 - Mar 31, 2022
    Role: Principal Investigator
    MECHANISMS OF CORTICOSTEROID RECEPTOR FUNCTION IN BRAIN
    NIH R01DK054376Sep 25, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Mechanisms of Mineralcorticoid Receptor Function
    NIH R56DK051151Jun 1, 1996 - Jul 31, 2009
    Role: Principal Investigator
    Mechanisms of Mineralcorticoid Receptor Function
    NIH R01DK051151Jun 1, 1996 - May 31, 2007
    Role: Principal Investigator
    MECHANISMS OF MINERALOCORTICOID RECEPTOR FUNCTION
    NIH R29DK051151Jun 1, 1996 - May 31, 2002
    Role: Principal Investigator
    ROLE OF GENE REGULATION IN RENAL PHYSIOLOGIC RESPONSES
    NIH K11DK001877Sep 30, 1988 - Aug 31, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity. Pflugers Arch. 2024 Sep 10. Verouti S, Aeschlimann G, Wang Q, Del Olmo DA, Peyter AC, Menétrey S, Winter DV, Odermatt A, Pearce D, Hummler E, Vanderriele PE. PMID: 39256246.
      View in: PubMed   Mentions:    Fields:    
    2. Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium. bioRxiv. 2024 Jun 27. Demko J, Saha B, Takagi E, Mannis A, Weber R, Pearce D. PMID: 38979219; PMCID: PMC11230149.
      View in: PubMed   Mentions:
    3. Aldosterone-independent regulation of K + secretion in the distal nephron. Curr Opin Nephrol Hypertens. 2024 Sep 01; 33(5):526-534. Demko J, Weber R, Pearce D, Saha B. PMID: 38888034; PMCID: PMC11290980.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Site-specific activity of mTORC2 in regulating renal K+ secretion to maintain ion homeostasis. Physiology. 2023 May 1; 38(S1):5735093. Saha SB, Takagi TE, Demko DJ, Manis MA, Pearce PD. .
      View in: Publisher Site   Mentions:
    5. Renal tubule mTORC2 deletion increases gluconeogenesis and urinary glucose excretion. Physiology. 2023 May 1; 38(S1):5735039. Demko DJ, Saha SB, Takagi TE, Manis MA, Richman RP, Pearce PD. .
      View in: Publisher Site   Mentions:
    6. Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium. J Am Soc Nephrol. 2023 06 01; 34(6):1019-1038. Saha B, Shabbir W, Takagi E, Duan XP, Leite Dellova DCA, Demko J, Manis A, Loffing-Cueni D, Loffing J, Sørensen MV, Wang WH, Pearce D. PMID: 36890646; PMCID: PMC10278851.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport. J Cell Sci. 2022 12 01; 135(23). Saha B, Leite-Dellova DCA, Demko J, Sørensen MV, Takagi E, Gleason CE, Shabbir W, Pearce D. PMID: 36373794; PMCID: PMC9789407.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls. J Endocr Soc. 2022 Oct 26; 6(12):bvac144. Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL. PMID: 36338506; PMCID: PMC9619433.
      View in: PubMed   Mentions: 1  
    9. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J Biol Chem. 2022 09; 298(9):102288. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D. PMID: 35926713; PMCID: PMC9440446.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology. Pflugers Arch. 2022 08; 474(8):869-884. Pearce D, Manis AD, Nesterov V, Korbmacher C. PMID: 35895103; PMCID: PMC9338908.
      View in: PubMed   Mentions: 12     Fields:    
    11. Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold. J Biol Chem. 2021 Jan-Jun; 296:100632. Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D. PMID: 33865855; PMCID: PMC8121962.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19. Med Hypotheses. 2020 Nov; 144:110237. Stookey JD, Allu PKR, Chabas D, Pearce D, Lang F. PMID: 33254543; PMCID: PMC7467030.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansPHPublic Health
    13. Regulation of ENaC by aldosterone and potassium. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Dellova DD, Saha SB, Takagi TE, Shabbir SW, Pearce PD. .
      View in: Publisher Site   Mentions:
    14. mTOR Modulates Sodium and Potassium Conduction in Heterologous Expression System. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Shabbir SW, Gleason GC, Saha SB, Dellova DD, Pearce PD. .
      View in: Publisher Site   Mentions:
    15. Association of Urinary Plasminogen-Plasmin with Edema and Epithelial Sodium Channel Activation in Patients with Nephrotic Syndrome. Am J Nephrol. 2019; 50(2):92-104. Chen JL, Wang L, Yao XM, Zang YJ, Wang Y, Li ZJ, Pearce D, Wang H. PMID: 31269481.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Potassium acts through mTOR to regulate its own secretion. JCI Insight. 2019 04 23; 5. Sørensen MV, Saha B, Jensen IS, Wu P, Ayasse N, Gleason CE, Svendsen SL, Wang WH, Pearce D. PMID: 31013253; PMCID: PMC6629116.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    17. Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt. J Cell Sci. 2019 04 09; 132(7). Gleason CE, Oses-Prieto JA, Li KH, Saha B, Situ G, Burlingame AL, Pearce D. PMID: 30837283; PMCID: PMC6467483.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    18. The mTORC2-SGK1 Signaling Module Mediates Local Sensing of Potassium in Kidney Tubule Principal Cells to Activate ENaC and Promote Potassium Secretion. The FASEB Journal. 2019 Apr 1; 33(S1):862.28-862.28. Saha SB, Gleason GC, Wu WP, Wang WW, Pearce PD. .
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    19. The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex. Cell Death Dis. 2018 11 01; 9(11):1114. Yuan YP, Zhao H, Peng LQ, Li ZF, Liu S, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ. PMID: 30385740; PMCID: PMC6212497.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Potassium Can Regulate Its Own Excretion in Collecting Duct Cells: Role of mTORC2, SGK1 and ENaC. The FASEB Journal. 2018 Apr 1; 32:620.13-620.13. Saha SB, Wu WP, Gleason GC, Wang WW, Pearce PD. .
      View in: Publisher Site   Mentions:
    21. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo. Sci Rep. 2018 02 01; 8(1):2088. Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. PMID: 29391429; PMCID: PMC5794967.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    22. Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction. FASEB J. 2018 02; 32(2):576-587. Peng LQ, Zhao H, Liu S, Yuan YP, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ. PMID: 28935820; PMCID: PMC8793723.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 04; 79(4):1862-1869. von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. PMID: 29314217; PMCID: PMC5815327.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease. Biosci Rep. 2017 Dec 22; 37(6). Nelson T, Pearce DA, Kovács AD. PMID: 29089465; PMCID: PMC5700270.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron. Kidney Int. 2017 05; 91(5):1159-1177. Rashmi P, Colussi G, Ng M, Wu X, Kidwai A, Pearce D. PMID: 28094030; PMCID: PMC6034684.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 01; 77(1):65-73. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. PMID: 27859575; PMCID: PMC5191913.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    27. Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia. Metab Brain Dis. 2017 02; 32(1):275-279. Meyer M, Kovács AD, Pearce DA. PMID: 27722792; PMCID: PMC5335868.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver. Magn Reson Med. 2017 04; 77(4):1429-1437. von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. PMID: 27098724; PMCID: PMC5074920.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    29. Detecting Metabolism of Gluconeogenic Precursors Lactate and Pyruvate in Kidney & Liver with Hyperpolarized 13 C MRI. The FASEB Journal. 2016 Apr 1; 30(S1). von Morze vC, Chang CG, Larson LP, Shang SH, Allu AP, Bok BR, Crane CJ, Olson OM, Tan TC, Marco-Rius MI, Nelson NS, Kurhanewicz KJ, Pearce PD, Vigneron VD. .
      View in: Publisher Site   Mentions:
    30. Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med. 2017 04; 77(4):1419-1428. Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB. PMID: 27017966; PMCID: PMC5040611.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway. Nephrol Dial Transplant. 2016 Feb; 31(2):200-5. Lang F, Pearce D. PMID: 26163195; PMCID: PMC6281043.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    32. mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity. J Clin Invest. 2015 Jan; 125(1):117-28. Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D. PMID: 25415435; PMCID: PMC4382226.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    33. The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015 Jan 01; 24(1):185-96. Miller JN, Kovács AD, Pearce DA. PMID: 25205113; PMCID: PMC4326326.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    34. Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):135-46. Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE. PMID: 24875192; PMCID: PMC4284417.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    35. Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription. Am J Physiol Renal Physiol. 2013 Nov 15; 305(10):F1436-44. Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W. PMID: 24026182; PMCID: PMC3840248.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3. PLoS One. 2013; 8(6):e66203. Getty A, Kovács AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH, Pearce DA. PMID: 23840424; PMCID: PMC3688782.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Jul 01; 22(13):2723-34. Miller JN, Chan CH, Pearce DA. PMID: 23539563; PMCID: PMC4439521.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    38. Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24; 199(7):1145-58. Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH. PMID: 23266958; PMCID: PMC3529522.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    39. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cell Physiol Biochem. 2012; 30(6):1423-35. Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F. PMID: 23171960; PMCID: PMC6175581.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    40. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. PMID: 22851176; PMCID: PMC3463358.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    41. Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease. Neuropharmacology. 2012 Oct; 63(5):769-75. Kovács AD, Saje A, Wong A, Ramji S, Cooper JD, Pearce DA. PMID: 22683643; PMCID: PMC3408822.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    42. The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis. Sex Dev. 2012; 6(4):169-77. Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S. PMID: 22571926; PMCID: PMC6187839.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    43. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun; 26(6):1000-13. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E. PMID: 22556341; PMCID: PMC5416992.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    44. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012 Jul-Aug; 47(4):349-59. Soundararajan R, Lu M, Pearce D. PMID: 22506713; PMCID: PMC4319811.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    45. Chapter 6 Aldosterone Regulation of Ion Transport. Brenner and Rector\u0027s The Kidney. 2012 Jan 1; 202-225. Pearce PD, Bhalla BV, Funder FJ, Stokes SJ. .
      View in: Publisher Site   Mentions:
    46. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012 Mar 24; 350(2):242-7. Soundararajan R, Pearce D, Ziera T. PMID: 22101317; PMCID: PMC3270213.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    47. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 2011 Dec; 25(12):2106-18. Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. PMID: 21980074; PMCID: PMC3231839.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    48. Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis. J Neurosci Res. 2012 Feb; 90(2):367-75. Finn R, Kovács AD, Pearce DA. PMID: 21971706; PMCID: PMC3237775.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    49. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011 Sep 02; 286(35):30647-30654. Lu M, Wang J, Ives HE, Pearce D. PMID: 21757730; PMCID: PMC3162425.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    50. Identification of CNK3 in the Aldosterone-regulated ENaC Regulatory Complex. The FASEB Journal. 2011 Apr 1; 25:950.1-950.1. Ziera ZT, Koo KE, Soundararajan SR, Pearce PD. .
      View in: Publisher Site   Mentions:
    51. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 2011 Jul; 80(1):61-7. Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F. PMID: 21451460; PMCID: PMC6049080.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    52. Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3(Δex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. Neurochem Int. 2011 May; 58(6):648-55. Finn R, Kovács AD, Pearce DA. PMID: 21315126; PMCID: PMC3164971.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    53. Cardiovascular effects of melanocortins. Eur J Pharmacol. 2011 Jun 11; 660(1):43-52. Humphreys MH, Ni XP, Pearce D. PMID: 21199648; PMCID: PMC3086937.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    54. Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3. J Gastroenterol. 2011 Mar; 46(3):305-17. Pasham V, Rotte A, Bhandaru M, Eichenmüller M, Fröhlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F. PMID: 21113728; PMCID: PMC6049078.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    55. Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease. Neuropharmacology. 2011 Feb-Mar; 60(2-3):405-9. Kovács AD, Saje A, Wong A, Szénási G, Kiricsi P, Szabó E, Cooper JD, Pearce DA. PMID: 20971125; PMCID: PMC3174473.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    56. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem. 2010 Dec 17; 285(51):39905-13. Soundararajan R, Wang J, Melters D, Pearce D. PMID: 20947508; PMCID: PMC3000972.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    57. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1496-506. Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D. PMID: 20926631; PMCID: PMC3006302.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    58. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1007-14. Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F. PMID: 20686074; PMCID: PMC3774517.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    59. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem. 2010 Oct 01; 285(40):30363-9. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. PMID: 20624922; PMCID: PMC2945528.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    60. Regulation of gastric acid secretion by PKB/Akt2. Cell Physiol Biochem. 2010; 25(6):695-704. Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F. PMID: 20511715; PMCID: PMC3709192.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    61. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724; PMCID: PMC2898378.
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    62. GILZ1: a key molecular determinant of intracellular signaling specificity governing epithelial sodium transport. The FASEB Journal. 2010 Apr 1; 24:701.9-701.9. Soundararajan SR, Wang WJ, Melters MD, Shih SI, Pearce PD. .
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    63. Phosphopeptide Screen Uncovers JNK1 as a Potentiator of Nedd4-2-Mediated Epithelial Na+ Channel Inhibition. The FASEB Journal. 2010 Apr 1; 24:611.18-611.18. Bhalla BV, Oyster ON, Wijngaarden WM, Lee LJ, Li LH, Xia XX, Huang HZ, Chalkley CR, Burlingame BA, Pearce PD, Hallows HK. .
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    64. Akt/PKB-sensitive proximal tubular glucose and phosphate transport. The FASEB Journal. 2010 Apr 1; 24:606.5-606.5. Föller FM, Kempe KD, Siraskar SG, Fröhlich FH, Ackermann AT, Siraskar SB, Völkl VH, Judenhofer JM, Pichler PB, Leavens LK, Birnbaum BM, Pearce PD, Lang LF. .
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    65. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. PMID: 20338997; PMCID: PMC2865740.
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    66. Akt2/PKBbeta-sensitive regulation of renal phosphate transport. Acta Physiol (Oxf). 2010 Sep; 200(1):75-85. Kempe DS, Ackermann TF, Boini KM, Klaus F, Umbach AT, Dërmaku-Sopjani M, Judenhofer MS, Pichler BJ, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F. PMID: 20236253.
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    67. Regulation of renal tubular glucose reabsorption by Akt2/PKBβ. Am J Physiol Renal Physiol. 2010 May; 298(5):F1113-7. Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F. PMID: 20164156; PMCID: PMC4116394.
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    68. Akt2 and SGK3 are both determinants of postnatal hair follicle development. FASEB J. 2009 Sep; 23(9):3193-202. Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D. PMID: 19433625; PMCID: PMC2735357.
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    69. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone. Exp Physiol. 2009 Aug; 94(8):867-76. Ni XP, van Dijk C, Pearce D, Humphreys MH. PMID: 19429645; PMCID: PMC2853237.
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    70. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7804-9. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. PMID: 19380724; PMCID: PMC2683131.
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    71. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 03; 7(3):e60. Jones KT, Greer ER, Pearce D, Ashrafi K. PMID: 19260765; PMCID: PMC2650726.
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    72. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50. Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. PMID: 18653476; PMCID: PMC2536874.
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    73. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem. 2007 Dec 14; 282(50):36303-13. Soundararajan R, Wang J, Melters D, Pearce D. PMID: 17956870.
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    74. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1741-50. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. PMID: 17356130.
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    75. Salt, sodium channels, and SGK1. J Clin Invest. 2007 Mar; 117(3):592-5. Pearce D, Kleyman TR. PMID: 17332888; PMCID: PMC1804371.
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    76. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. PMID: 16844684.
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    77. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F714-21. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. PMID: 16720863.
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    78. Renal function of gene-targeted mice lacking both SGK1 and SGK3. Am J Physiol Regul Integr Comp Physiol. 2006 Apr; 290(4):R945-50. Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F. PMID: 16537821.
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    79. Inhibition of the Epithelial Sodium Channel by AMP-Activated Kinase Involves Modulation of Nedd4-2 Activity. The FASEB Journal. 2006 Mar 1; 20(4):a795-a796. Hallows HK, Oyster ON, Bhalla BV, Pearce PD. .
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    80. Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse. Behav Brain Res. 2006 Feb 15; 167(1):75-86. Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F. PMID: 16246437.
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    81. A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport. J Biol Chem. 2005 Dec 02; 280(48):39970-81. Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D. PMID: 16216878.
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    82. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R560-7. Ni XP, Bhargava A, Pearce D, Humphreys MH. PMID: 16195498.
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    83. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol. 2005 Dec; 19(12):3073-84. Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D. PMID: 16099816.
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    84. Decreased intestinal glucose transport in the sgk3-knockout mouse. Pflugers Arch. 2005 Dec; 451(3):437-44. Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F. PMID: 15971077.
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    85. SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology (Bethesda). 2005 Apr; 20:134-9. McCormick JA, Bhalla V, Pao AC, Pearce D. PMID: 15772302.
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    86. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol. 2005 Jun 01; 565(Pt 2):381-90. Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F. PMID: 15774536; PMCID: PMC1464516.
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    87. Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures. Curr Genet. 2005 Feb; 47(2):67-83. Chen X, Moerschell RP, Pearce DA, Ramanan DD, Sherman F. PMID: 15605252.
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    88. Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling. Endocrinology. 2005 Mar; 146(3):1438-48. Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, de Kloet ER. PMID: 15564339.
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    89. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell. 2004 Sep; 15(9):4278-88. McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D. PMID: 15240817; PMCID: PMC515358.
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    90. Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides. Brain Res Brain Res Protoc. 2004 Jun; 13(2):115-25. Bhargava A, Dallman MF, Pearce D, Choi S. PMID: 15171994.
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    91. Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products. Trends Endocrinol Metab. 2004 May-Jun; 15(4):147-53. Bhargava A, Pearce D. PMID: 15109612.
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    92. Regulation of epithelial ion transport by aldosterone through changes in gene expression. Mol Cell Endocrinol. 2004 Mar 31; 217(1-2):189-96. Bhargava A, Wang J, Pearce D. PMID: 15134817.
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    93. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. PMID: 15007040.
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    94. Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants. Mol Endocrinol. 2003 Dec; 17(12):2583-92. Adams M, Meijer OC, Wang J, Bhargava A, Pearce D. PMID: 12933902.
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    95. Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities. Endocrinology. 2003 Oct; 144(10):4226-36. Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD. PMID: 12959971.
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    96. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest. 2003 Apr; 111(8):1251-8. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH. PMID: 12697744; PMCID: PMC152936.
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    97. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Pflugers Arch. 2003 Mar; 445(6):693-6. Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F. PMID: 12632189.
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    98. SGK1 regulation of epithelial sodium transport. Cell Physiol Biochem. 2003; 13(1):13-20. Pearce D. PMID: 12649598.
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    99. Aldosterone: its receptor, target genes, and actions. Vitam Horm. 2003; 66:29-76. Pearce D, Bhargava A, Cole TJ. PMID: 12852252.
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    100. The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J Am Soc Nephrol. 2002 Dec; 13(12):2823-30. Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F. PMID: 12444200.
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    101. Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F254-61. Edinger RS, Watkins SC, Pearce D, Johnson JP. PMID: 12110508.
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    102. Hypotonic induction of SGK1 and Na+ transport in A6 cells. Am J Physiol Renal Physiol. 2002 Jul; 283(1):F105-13. Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D. PMID: 12060592.
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    103. Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1. Mol Endocrinol. 2002 Jul; 16(7):1629-37. Bhargava A, Mathias RS, McCormick JA, Dallman MF, Pearce D. PMID: 12089356.
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    104. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J. 2001 Dec 17; 20(24):7052-9. Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O. PMID: 11742982; PMCID: PMC125341.
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    105. Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors. J Biol Chem. 2002 Jan 11; 277(2):1451-6. Pearce D, Náray-Fejes-Tóth A, Fejes-Tóth G. PMID: 11677231.
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    106. The role of SGK1 in hormone-regulated sodium transport. Trends Endocrinol Metab. 2001 Oct; 12(8):341-7. Pearce D. PMID: 11551807.
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    107. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol. 2001 Apr; 280(4):F675-82. Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F. PMID: 11249859.
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    108. The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Endocrinology. 2001 Apr; 142(4):1587-94. Bhargava A, Fullerton MJ, Myles K, Purdy TM, Funder JW, Pearce D, Cole TJ. PMID: 11250940.
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    109. The Serum- and Glucocorticoid-Induced Kinase Is a Physiological Mediator of Aldosterone Action*. Endocrinology. 2001 Apr 1; 142(4):1587-1594. Bhargava BA, Fullerton FM, Myles MK, Purdy PT, Funder FJ, Pearce PD, Cole CT. .
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    110. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol. 2001 Feb; 280(2):F303-13. Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D. PMID: 11208606.
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    111. Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest. J Virol. 2000 Sep; 74(17):8159-65. Sherman MP, de Noronha CM, Pearce D, Greene WC. PMID: 10933727; PMCID: PMC112350.
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    112. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol. 2000 Aug; 20(16):6040-50. Iñiguez-Lluhí JA, Pearce D. PMID: 10913186; PMCID: PMC86080.
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    113. Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus. J Neurosci. 2000 May 01; 20(9):3129-38. Bhargava A, Meijer OC, Dallman MF, Pearce D. PMID: 10777776; PMCID: PMC6773119.
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    114. Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms. Kidney Int. 2000 Apr; 57(4):1277-82. Verrey F, Pearce D, Pfeiffer R, Spindler B, Mastroberardino L, Summa V, Zecevic M. PMID: 10760054.
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    115. Role of SGK in mineralocorticoid-regulated sodium transport. Kidney Int. 2000 Apr; 57(4):1283-9. Pearce D, Verrey F, Chen SY, Mastroberardino L, Meijer OC, Wang J, Bhargava A. PMID: 10760055.
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    116. Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context. J Neuroendocrinol. 2000 Mar; 12(3):245-54. Meijer OC, Williamson A, Dallman MF, Pearce D. PMID: 10718920.
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    117. Regulation of the rat serotonin-1A receptor gene by corticosteroids. J Biol Chem. 2000 Jan 14; 275(2):1321-6. Wissink S, Meijer O, Pearce D, van Der Burg B, van Der Saag PT. PMID: 10625680.
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    118. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol. 1999 Aug; 181(16):4774-9. Pearce DA, Sherman F. PMID: 10438744; PMCID: PMC93961.
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    119. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Mol Cell Biol. 1999 Jul; 19(7):5036-49. Rogatsky I, Hittelman AB, Pearce D, Garabedian MJ. PMID: 10373553; PMCID: PMC84339.
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    120. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2514-9. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D. PMID: 10051674; PMCID: PMC26816.
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    121. Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites. J Biol Chem. 1998 Nov 13; 273(46):30081-5. Pearce D, Matsui W, Miner JN, Yamamoto KR. PMID: 9804760.
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    122. Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2973-8. Fejes-Tóth G, Pearce D, Náray-Fejes-Tóth A. PMID: 9501200; PMCID: PMC19679.
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    123. Aldosterone responsiveness of A6 cells is restored by cloned rat mineralocorticoid receptor. Am J Physiol. 1998 01; 274(1):C39-46. Chen SY, Wang J, Liu W, Pearce D. PMID: 9458711.
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    124. Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity. J Biol Chem. 1997 May 30; 272(22):14087-92. Chen Sy, Wang J, Yu Gq, Liu W, Pearce D. PMID: 9162033.
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    125. The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter. Microbiology (Reading). 1997 Feb; 143 ( Pt 2):563-576. Page MD, Pearce DA, Norris HAC, Ferguson SJ. PMID: 9043133.
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    127. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12480-4. Liu W, Wang J, Sauter NK, Pearce D. PMID: 8618925; PMCID: PMC40381.
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    129. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science. 1993 Feb 19; 259(5098):1161-5. Pearce D, Yamamoto KR. PMID: 8382376.
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    131. NaCl reflection coefficients in proximal tubule apical and basolateral membrane vesicles. Measurement by induced osmosis and solvent drag. Biophys J. 1989 Jun; 55(6):1251-9. Pearce D, Verkman AS. PMID: 2765660; PMCID: PMC1330589.
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