David Pearce, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-502-4326
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1989 Medicine
    University of California, San FranciscoResidency

    Collapse Overview 
    Collapse Overview
    EDUCATION
    College: University of California, Berkeley BA (Mathematics)
    Medical School: University of Chicago, Pritzker School of Medicine, MD
    Internal Medicine Residency: Harbor-UCLA Medical Center
    Nephrology Fellowship: University of California, San Francisco

    Dr. Pearce's research focuses on understanding the cellular and molecular mechanisms underlying hormone-regulated ion transport in the kidney tubules. His lab has cloned and characterized several key regulatory proteins involved in the control of epithelial Na+ and K+ transport. Notably, SGK1 is a serine-threonine signaling kinase, which mediates the effects of multiple hormones, and is necessary for normal Na+ and K+ homeostasis. Defects in SGK1 result in pseudohypoaldosteronism (Na+ wasting and inability to excrete K+ despite high aldosterone levels).

    His group has made seminal contributions to our understanding of how the effects of SGK1 and other signaling proteins are integrated to achieve specific regulation of ion transport. Recently, his lab identified a large multiprotein complex, which integrates manifold inputs that impact on Na+ transport in kidney tubule cells. The principal goal of this basic research is to identify points of entry for treatment of diseases such as hypertension and metabolic syndrome. Already, SGK1 inhibitors are in preclinical testing for the treatment of salt sensitive hypertension.

    Dr. Pearce's research is funded by two R01's from the NIDDK, and several Foundation awards.

    Dr. Pearce is Professor of Medicine and Cellular & Molecular Pharmacology at UCSF, and Chief of Nephrology at San Francisco General Hospital, one of the core teaching hospitals affiliated with UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    GILZ Regulation of ENaC
    NIH R01DK085101Aug 1, 2009 - Jul 31, 2014
    Role: Principal Investigator
    SGK Regulation of Epithelial Sodium Transport
    NIH R01DK056695Aug 15, 2000 - Mar 31, 2022
    Role: Principal Investigator
    MECHANISMS OF CORTICOSTEROID RECEPTOR FUNCTION IN BRAIN
    NIH R01DK054376Sep 25, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Mechanisms of Mineralcorticoid Receptor Function
    NIH R56DK051151Jun 1, 1996 - Jul 31, 2009
    Role: Principal Investigator
    Mechanisms of Mineralcorticoid Receptor Function
    NIH R01DK051151Jun 1, 1996 - May 31, 2007
    Role: Principal Investigator
    MECHANISMS OF MINERALOCORTICOID RECEPTOR FUNCTION
    NIH R29DK051151Jun 1, 1996 - May 31, 2002
    Role: Principal Investigator
    ROLE OF GENE REGULATION IN RENAL PHYSIOLOGIC RESPONSES
    NIH K11DK001877Sep 30, 1988 - Aug 31, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold. J Biol Chem. 2021 Jan-Jun; 296:100632. Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D. PMID: 33865855.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19. Med Hypotheses. 2020 Nov; 144:110237. Stookey JD, Allu PKR, Chabas D, Pearce D, Lang F. PMID: 33254543.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    3. mTOR Modulates Sodium and Potassium Conduction in Heterologous Expression System. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Shabbir SW, Gleason GC, Saha SB, Dellova DD, Pearce PD. .
      View in: Publisher Site   Mentions:
    4. Regulation of ENaC by aldosterone and potassium. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Dellova DD, Saha SB, Takagi TE, Shabbir SW, Pearce PD. .
      View in: Publisher Site   Mentions:
    5. Association of Urinary Plasminogen-Plasmin with Edema and Epithelial Sodium Channel Activation in Patients with Nephrotic Syndrome. Am J Nephrol. 2019; 50(2):92-104. Chen JL, Wang L, Yao XM, Zang YJ, Wang Y, Li ZJ, Pearce D, Wang H. PMID: 31269481.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Potassium acts through mTOR to regulate its own secretion. JCI Insight. 2019 04 23; 5. Sørensen MV, Saha B, Jensen IS, Wu P, Ayasse N, Gleason CE, Svendsen SL, Wang WH, Pearce D. PMID: 31013253.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt. J Cell Sci. 2019 04 09; 132(7). Gleason CE, Oses-Prieto JA, Li KH, Saha B, Situ G, Burlingame AL, Pearce D. PMID: 30837283.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    8. The mTORC2-SGK1 Signaling Module Mediates Local Sensing of Potassium in Kidney Tubule Principal Cells to Activate ENaC and Promote Potassium Secretion. The FASEB Journal. 2019 Apr 1; 33(S1):862.28-862.28. Saha SB, Gleason GC, Wu WP, Wang WW, Pearce PD. .
      View in: Publisher Site   Mentions:
    9. The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex. Cell Death Dis. 2018 11 01; 9(11):1114. Yuan YP, Zhao H, Peng LQ, Li ZF, Liu S, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ. PMID: 30385740.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Potassium Can Regulate Its Own Excretion in Collecting Duct Cells: Role of mTORC2, SGK1 and ENaC. The FASEB Journal. 2018 Apr 1; 32:620.13-620.13. Saha SB, Wu WP, Gleason GC, Wang WW, Pearce PD. .
      View in: Publisher Site   Mentions:
    11. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo. Sci Rep. 2018 02 01; 8(1):2088. Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. PMID: 29391429.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction. FASEB J. 2018 02; 32(2):576-587. Peng LQ, Zhao H, Liu S, Yuan YP, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ. PMID: 28935820.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 04; 79(4):1862-1869. von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. PMID: 29314217.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease. Biosci Rep. 2017 Dec 22; 37(6). Nelson T, Pearce DA, Kovács AD. PMID: 29089465.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron. Kidney Int. 2017 05; 91(5):1159-1177. Rashmi P, Colussi G, Ng M, Wu X, Kidwai A, Pearce D. PMID: 28094030.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 01; 77(1):65-73. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. PMID: 27859575.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    17. Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia. Metab Brain Dis. 2017 02; 32(1):275-279. Meyer M, Kovács AD, Pearce DA. PMID: 27722792.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver. Magn Reson Med. 2017 04; 77(4):1429-1437. von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. PMID: 27098724.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    19. Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med. 2017 04; 77(4):1419-1428. Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB. PMID: 27017966.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway. Nephrol Dial Transplant. 2016 Feb; 31(2):200-5. Lang F, Pearce D. PMID: 26163195.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    21. mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity. J Clin Invest. 2015 Jan; 125(1):117-28. Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D. PMID: 25415435.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015 Jan 01; 24(1):185-96. Miller JN, Kovács AD, Pearce DA. PMID: 25205113.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    23. Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):135-46. Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE. PMID: 24875192.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    24. Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription. Am J Physiol Renal Physiol. 2013 Nov 15; 305(10):F1436-44. Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W. PMID: 24026182.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3. PLoS One. 2013; 8(6):e66203. Getty A, Kovács AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH, Pearce DA. PMID: 23840424.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Jul 01; 22(13):2723-34. Miller JN, Chan CH, Pearce DA. PMID: 23539563.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    27. Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24; 199(7):1145-58. Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH. PMID: 23266958.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cell Physiol Biochem. 2012; 30(6):1423-35. Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F. PMID: 23171960.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    29. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. PMID: 22851176.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    30. Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease. Neuropharmacology. 2012 Oct; 63(5):769-75. Kovács AD, Saje A, Wong A, Ramji S, Cooper JD, Pearce DA. PMID: 22683643.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis. Sex Dev. 2012; 6(4):169-77. Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S. PMID: 22571926.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun; 26(6):1000-13. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E. PMID: 22556341.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    33. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012 Jul-Aug; 47(4):349-59. Soundararajan R, Lu M, Pearce D. PMID: 22506713.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    34. Chapter 6 Aldosterone Regulation of Ion Transport. Brenner and Rector\u0027s The Kidney. 2012 Jan 1; 202-225. Pearce PD, Bhalla BV, Funder FJ, Stokes SJ. .
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    35. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012 Mar 24; 350(2):242-7. Soundararajan R, Pearce D, Ziera T. PMID: 22101317.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    36. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 2011 Dec; 25(12):2106-18. Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. PMID: 21980074.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    37. Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis. J Neurosci Res. 2012 Feb; 90(2):367-75. Finn R, Kovács AD, Pearce DA. PMID: 21971706.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    38. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011 Sep 02; 286(35):30647-30654. Lu M, Wang J, Ives HE, Pearce D. PMID: 21757730.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    39. Identification of CNK3 in the Aldosterone-regulated ENaC Regulatory Complex. The FASEB Journal. 2011 Apr 1; 25:950.1-950.1. Ziera ZT, Koo KE, Soundararajan SR, Pearce PD. .
      View in: Publisher Site   Mentions:
    40. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 2011 Jul; 80(1):61-7. Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F. PMID: 21451460.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    41. Cardiovascular effects of melanocortins. Eur J Pharmacol. 2011 Jun 11; 660(1):43-52. Humphreys MH, Ni XP, Pearce D. PMID: 21199648.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3. J Gastroenterol. 2011 Mar; 46(3):305-17. Pasham V, Rotte A, Bhandaru M, Eichenmüller M, Fröhlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F. PMID: 21113728.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease. Neuropharmacology. 2011 Feb-Mar; 60(2-3):405-9. Kovács AD, Saje A, Wong A, Szénási G, Kiricsi P, Szabó E, Cooper JD, Pearce DA. PMID: 20971125.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    44. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem. 2010 Dec 17; 285(51):39905-13. Soundararajan R, Wang J, Melters D, Pearce D. PMID: 20947508.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    45. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1496-506. Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D. PMID: 20926631.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    46. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. . 2010 Nov; 299(5):C1007-14. Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F. PMID: 20686074.
      View in: PubMed   Mentions:
    47. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem. 2010 Oct 01; 285(40):30363-9. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. PMID: 20624922.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    48. Regulation of gastric acid secretion by PKB/Akt2. Cell Physiol Biochem. 2010; 25(6):695-704. Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F. PMID: 20511715.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    50. Akt/PKB-sensitive proximal tubular glucose and phosphate transport. The FASEB Journal. 2010 Apr 1; 24:606.5-606.5. Föller FM, Kempe KD, Siraskar SG, Fröhlich FH, Ackermann AT, Siraskar SB, Völkl VH, Judenhofer JM, Pichler PB, Leavens LK, Birnbaum BM, Pearce PD, Lang LF. .
      View in: Publisher Site   Mentions:
    51. GILZ1: a key molecular determinant of intracellular signaling specificity governing epithelial sodium transport. The FASEB Journal. 2010 Apr 1; 24:701.9-701.9. Soundararajan SR, Wang WJ, Melters MD, Shih SI, Pearce PD. .
      View in: Publisher Site   Mentions:
    52. Phosphopeptide Screen Uncovers JNK1 as a Potentiator of Nedd4-2-Mediated Epithelial Na+ Channel Inhibition. The FASEB Journal. 2010 Apr 1; 24:611.18-611.18. Bhalla BV, Oyster ON, Wijngaarden WM, Lee LJ, Li LH, Xia XX, Huang HZ, Chalkley CR, Burlingame BA, Pearce PD, Hallows HK. .
      View in: Publisher Site   Mentions:
    53. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. PMID: 20338997.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    54. Akt2/PKBbeta-sensitive regulation of renal phosphate transport. Acta Physiol (Oxf). 2010 Sep; 200(1):75-85. Kempe DS, Ackermann TF, Boini KM, Klaus F, Umbach AT, Dërmaku-Sopjani M, Judenhofer MS, Pichler BJ, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F. PMID: 20236253.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. Regulation of renal tubular glucose reabsorption by Akt2/PKBβ. Am J Physiol Renal Physiol. 2010 May; 298(5):F1113-7. Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F. PMID: 20164156.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    56. Akt2 and SGK3 are both determinants of postnatal hair follicle development. FASEB J. 2009 Sep; 23(9):3193-202. Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D. PMID: 19433625.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    57. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone. Exp Physiol. 2009 Aug; 94(8):867-76. Ni XP, van Dijk C, Pearce D, Humphreys MH. PMID: 19429645.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    58. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7804-9. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. PMID: 19380724.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    59. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 03; 7(3):e60. Jones KT, Greer ER, Pearce D, Ashrafi K. PMID: 19260765.
      View in: PubMed   Mentions: 85     Fields:    Translation:Animals
    60. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50. Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. PMID: 18653476.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    61. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem. 2007 Dec 14; 282(50):36303-13. Soundararajan R, Wang J, Melters D, Pearce D. PMID: 17956870.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    62. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1741-50. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. PMID: 17356130.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    63. Salt, sodium channels, and SGK1. J Clin Invest. 2007 Mar; 117(3):592-5. Pearce D, Kleyman TR. PMID: 17332888.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    64. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. PMID: 16844684.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    65. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F714-21. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. PMID: 16720863.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
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