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David Pearce, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address1001 Potrero Ave, SFGH 100
San Francisco CA 94110
Phone415-476-7015
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1989 Medicine
    University of California, San FranciscoResidency

    Collapse Overview 
    Collapse Overview
    EDUCATION
    College: University of California, Berkeley BA (Mathematics)
    Medical School: University of Chicago, Pritzker School of Medicine, MD
    Internal Medicine Residency: Harbor-UCLA Medical Center
    Nephrology Fellowship: University of California, San Francisco

    Dr. Pearce's research focuses on understanding the cellular and molecular mechanisms underlying hormone-regulated ion transport in the kidney tubules. His lab has cloned and characterized several key regulatory proteins involved in the control of epithelial Na+ and K+ transport. Notably, SGK1 is a serine-threonine signaling kinase, which mediates the effects of multiple hormones, and is necessary for normal Na+ and K+ homeostasis. Defects in SGK1 result in pseudohypoaldosteronism (Na+ wasting and inability to excrete K+ despite high aldosterone levels).

    His group has made seminal contributions to our understanding of how the effects of SGK1 and other signaling proteins are integrated to achieve specific regulation of ion transport. Recently, his lab identified a large multiprotein complex, which integrates manifold inputs that impact on Na+ transport in kidney tubule cells. The principal goal of this basic research is to identify points of entry for treatment of diseases such as hypertension and metabolic syndrome. Already, SGK1 inhibitors are in preclinical testing for the treatment of salt sensitive hypertension.

    Dr. Pearce's research is funded by two R01's from the NIDDK, and several Foundation awards.

    Dr. Pearce is Professor of Medicine and Cellular & Molecular Pharmacology at UCSF, and Chief of Nephrology at San Francisco General Hospital, one of the core teaching hospitals affiliated with UCSF.


    Collapse Research 
    Collapse Research Activities and Funding
    GILZ Regulation of ENaC
    NIH/NIDDK R01DK085101Aug 1, 2009 - Jul 31, 2013
    Role: Principal Investigator
    SGK Regulation of Epithelial Sodium Transport
    NIH/NIDDK R01DK056695Aug 15, 2000 - Mar 31, 2022
    Role: Principal Investigator
    MECHANISMS OF CORTICOSTEROID RECEPTOR FUNCTION IN BRAIN
    NIH/NIDDK R01DK054376Sep 25, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Mechanisms of Mineralcorticoid Receptor Function
    NIH/NIDDK R56DK051151Jun 1, 1996 - Jul 31, 2009
    Role: Principal Investigator
    Mechanisms of Mineralcorticoid Receptor Function
    NIH/NIDDK R01DK051151Jun 1, 1996 - May 31, 2007
    Role: Principal Investigator
    MECHANISMS OF MINERALOCORTICOID RECEPTOR FUNCTION
    NIH/NIDDK R29DK051151Jun 1, 1996 - May 31, 2002
    Role: Principal Investigator
    ROLE OF GENE REGULATION IN RENAL PHYSIOLOGIC RESPONSES
    NIH/NIDDK K11DK001877Sep 30, 1988 - Aug 31, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo. Sci Rep. 2018 Feb 01; 8(1):2088. PMID: 29391429.
      View in: PubMed
    2. Peng LQ, Zhao H, Liu S, Yuan YP, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ. Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction. FASEB J. 2018 Feb; 32(2):576-587. PMID: 28935820.
      View in: PubMed
    3. von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 Apr; 79(4):1862-1869. PMID: 29314217.
      View in: PubMed
    4. Nelson T, Pearce DA, Kovács AD. Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease. Biosci Rep. 2017 Dec 22; 37(6). PMID: 29089465.
      View in: PubMed
    5. See-Too WS, Ee R, Lim YL, Convey P, Pearce DA, Yin WF, Chan KG. AidP, a novel N-Acyl homoserine lactonase gene from Antarctic Planococcus sp. Sci Rep. 2017 Feb 22; 7:42968. PMID: 28225085.
      View in: PubMed
    6. Rashmi P, Colussi G, Ng M, Wu X, Kidwai A, Pearce D. Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron. Kidney Int. 2017 05; 91(5):1159-1177. PMID: 28094030.
      View in: PubMed
    7. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 Jan; 77(1):65-73. PMID: 27859575.
      View in: PubMed
    8. Meyer M, Kovács AD, Pearce DA. Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia. Metab Brain Dis. 2017 02; 32(1):275-279. PMID: 27722792.
      View in: PubMed
    9. Wright S, Hull T, Sivyer DB, Pearce D, Pinnegar JK, Sayer MD, Mogg AO, Azzopardi E, Gontarek S, Hyder K. SCUBA divers as oceanographic samplers: The potential of dive computers to augment aquatic temperature monitoring. Sci Rep. 2016 07 22; 6:30164. PMID: 27445104.
      View in: PubMed
    10. von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver. Magn Reson Med. 2017 Apr; 77(4):1429-1437. PMID: 27098724.
      View in: PubMed
    11. Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB. Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med. 2017 Apr; 77(4):1419-1428. PMID: 27017966.
      View in: PubMed
    12. Lang F, Pearce D. Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway. Nephrol Dial Transplant. 2016 Feb; 31(2):200-5. PMID: 26163195.
      View in: PubMed
    13. Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D. mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity. J Clin Invest. 2015 Jan; 125(1):117-28. PMID: 25415435; PMCID: PMC4382226.
    14. Miller JN, Kovács AD, Pearce DA. The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015 Jan 01; 24(1):185-96. PMID: 25205113; PMCID: PMC4326326.
    15. Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE. Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):135-46. PMID: 24875192; PMCID: PMC4284417.
    16. Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W. Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase aENaC transcription. Am J Physiol Renal Physiol. 2013 Nov 15; 305(10):F1436-44. PMID: 24026182; PMCID: PMC3840248.
    17. Getty A, Kovács AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH, Pearce DA. Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3. PLoS One. 2013; 8(6):e66203. PMID: 23840424; PMCID: PMC3688782.
    18. Miller JN, Chan CH, Pearce DA. The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Jul 01; 22(13):2723-34. PMID: 23539563; PMCID: PMC4439521.
    19. Kovács AD, Pearce DA. Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains. Sci Rep. 2013; 3:2116. PMID: 23817037; PMCID: PMC3698490.
    20. Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH. Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24; 199(7):1145-58. PMID: 23266958; PMCID: PMC3529522.
    21. Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cell Physiol Biochem. 2012; 30(6):1423-35. PMID: 23171960.
      View in: PubMed
    22. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25. PMID: 22851176; PMCID: PMC3463358.
    23. Kovács AD, Saje A, Wong A, Ramji S, Cooper JD, Pearce DA. Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease. Neuropharmacology. 2012 Oct; 63(5):769-75. PMID: 22683643; PMCID: PMC3408822.
    24. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun; 26(6):1000-13. PMID: 22556341.
      View in: PubMed
    25. Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012 Jul-Aug; 47(4):349-59. PMID: 22506713; PMCID: PMC4319811.
    26. Soundararajan R, Pearce D, Ziera T. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012 Mar 24; 350(2):242-7. PMID: 22101317; PMCID: PMC3270213.
    27. Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 2011 Dec; 25(12):2106-18. PMID: 21980074; PMCID: PMC3231839.
    28. Finn R, Kovács AD, Pearce DA. Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis. J Neurosci Res. 2012 Feb; 90(2):367-75. PMID: 21971706; PMCID: PMC3237775.
    29. Lu M, Wang J, Ives HE, Pearce D. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011 Sep 02; 286(35):30647-54. PMID: 21757730; PMCID: PMC3162425.
    30. Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 2011 Jul; 80(1):61-7. PMID: 21451460.
      View in: PubMed
    31. Humphreys MH, Ni XP, Pearce D. Cardiovascular effects of melanocortins. Eur J Pharmacol. 2011 Jun 11; 660(1):43-52. PMID: 21199648; PMCID: PMC3086937.
    32. Pasham V, Rotte A, Bhandaru M, Eichenmüller M, Fröhlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F. Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3. J Gastroenterol. 2011 Mar; 46(3):305-17. PMID: 21113728.
      View in: PubMed
    33. Kovács AD, Saje A, Wong A, Szénási G, Kiricsi P, Szabó E, Cooper JD, Pearce DA. Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease. Neuropharmacology. 2011 Feb-Mar; 60(2-3):405-9. PMID: 20971125; PMCID: PMC3174473.
    34. Soundararajan R, Wang J, Melters D, Pearce D. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem. 2010 Dec 17; 285(51):39905-13. PMID: 20947508; PMCID: PMC3000972.
    35. Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1496-506. PMID: 20926631; PMCID: PMC3006302.
    36. Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1007-14. PMID: 20686074; PMCID: PMC3774517.
    37. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem. 2010 Oct 01; 285(40):30363-9. PMID: 20624922; PMCID: PMC2945528.
    38. Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F. Regulation of gastric acid secretion by PKB/Akt2. Cell Physiol Biochem. 2010; 25(6):695-704. PMID: 20511715; PMCID: PMC3709192.
    39. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. PMID: 20466724; PMCID: PMC2898378.
    40. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. PMID: 20338997; PMCID: PMC2865740.
    41. Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F. Regulation of renal tubular glucose reabsorption by Akt2/PKBß. Am J Physiol Renal Physiol. 2010 May; 298(5):F1113-7. PMID: 20164156; PMCID: PMC4116394.
    42. Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D. Akt2 and SGK3 are both determinants of postnatal hair follicle development. FASEB J. 2009 Sep; 23(9):3193-202. PMID: 19433625; PMCID: PMC2735357.
    43. Ni XP, van Dijk C, Pearce D, Humphreys MH. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone. Exp Physiol. 2009 Aug; 94(8):867-76. PMID: 19429645; PMCID: PMC2853237.
    44. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7804-9. PMID: 19380724; PMCID: PMC2683131.
    45. Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 03; 7(3):e60. PMID: 19260765; PMCID: PMC2650726.
    46. Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50. PMID: 18653476; PMCID: PMC2536874.
    47. Soundararajan R, Wang J, Melters D, Pearce D. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem. 2007 Dec 14; 282(50):36303-13. PMID: 17956870.
      View in: PubMed
    48. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1741-50. PMID: 17356130.
      View in: PubMed
    49. Pearce D, Kleyman TR. Salt, sodium channels, and SGK1. J Clin Invest. 2007 Mar; 117(3):592-5. PMID: 17332888; PMCID: PMC1804371.
    50. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69. PMID: 16844684.
      View in: PubMed
    51. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F714-21. PMID: 16720863.
      View in: PubMed
    52. Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F. Renal function of gene-targeted mice lacking both SGK1 and SGK3. Am J Physiol Regul Integr Comp Physiol. 2006 Apr; 290(4):R945-50. PMID: 16537821.
      View in: PubMed
    53. Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F. Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse. Behav Brain Res. 2006 Feb 15; 167(1):75-86. PMID: 16246437.
      View in: PubMed
    54. Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D. A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport. J Biol Chem. 2005 Dec 02; 280(48):39970-81. PMID: 16216878.
      View in: PubMed
    55. Ni XP, Bhargava A, Pearce D, Humphreys MH. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R560-7. PMID: 16195498.
      View in: PubMed
    56. Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol. 2005 Dec; 19(12):3073-84. PMID: 16099816.
      View in: PubMed
    57. Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F. Decreased intestinal glucose transport in the sgk3-knockout mouse. Pflugers Arch. 2005 Dec; 451(3):437-44. PMID: 15971077.
      View in: PubMed
    58. McCormick JA, Bhalla V, Pao AC, Pearce D. SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology (Bethesda). 2005 Apr; 20:134-9. PMID: 15772302.
      View in: PubMed
    59. Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol. 2005 Jun 01; 565(Pt 2):381-90. PMID: 15774536; PMCID: PMC1464516.
    60. McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell. 2004 Sep; 15(9):4278-88. PMID: 15240817; PMCID: PMC515358.
    61. Bhargava A, Dallman MF, Pearce D, Choi S. Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides. Brain Res Brain Res Protoc. 2004 Jun; 13(2):115-25. PMID: 15171994.
      View in: PubMed
    62. Bhargava A, Pearce D. Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products. Trends Endocrinol Metab. 2004 May-Jun; 15(4):147-53. PMID: 15109612.
      View in: PubMed
    63. Bhargava A, Wang J, Pearce D. Regulation of epithelial ion transport by aldosterone through changes in gene expression. Mol Cell Endocrinol. 2004 Mar 31; 217(1-2):189-96. PMID: 15134817.
      View in: PubMed
    64. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. PMID: 15007040.
      View in: PubMed
    65. Adams M, Meijer OC, Wang J, Bhargava A, Pearce D. Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants. Mol Endocrinol. 2003 Dec; 17(12):2583-92. PMID: 12933902.
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    66. Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD. Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities. Endocrinology. 2003 Oct; 144(10):4226-36. PMID: 12959971.
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    67. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest. 2003 Apr; 111(8):1251-8. PMID: 12697744; PMCID: PMC152936.
    68. Pearce D, Bhargava A, Cole TJ. Aldosterone: its receptor, target genes, and actions. Vitam Horm. 2003; 66:29-76. PMID: 12852252.
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    69. Pearce D. SGK1 regulation of epithelial sodium transport. Cell Physiol Biochem. 2003; 13(1):13-20. PMID: 12649598.
      View in: PubMed
    70. Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F. The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J Am Soc Nephrol. 2002 Dec; 13(12):2823-30. PMID: 12444200.
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    71. Edinger RS, Watkins SC, Pearce D, Johnson JP. Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F254-61. PMID: 12110508.
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    72. Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D. Hypotonic induction of SGK1 and Na+ transport in A6 cells. Am J Physiol Renal Physiol. 2002 Jul; 283(1):F105-13. PMID: 12060592.
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    73. Bhargava A, Mathias RS, McCormick JA, Dallman MF, Pearce D. Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1. Mol Endocrinol. 2002 Jul; 16(7):1629-37. PMID: 12089356.
      View in: PubMed
    74. Pearce D, Náray-Fejes-Tóth A, Fejes-Tóth G. Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors. J Biol Chem. 2002 Jan 11; 277(2):1451-6. PMID: 11677231.
      View in: PubMed