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Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC-92480), a novel cereblon E3 ligase modulator. CPT Pharmacometrics Syst Pharmacol. 2023 10; 12(10):1473-1484.
Wu F, Liu L, Gaudy A, Wang X, Carayannopoulos L, Pourdehnad M, Lamba M. PMID: 37705327; PMCID: PMC10583261.
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2 Fields:
Translation:
Humans
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Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma. N Engl J Med. 2023 09 14; 389(11):1009-1022.
Richardson PG, Trudel S, Popat R, Mateos MV, Vangsted AJ, Ramasamy K, Martinez-Lopez J, Quach H, Orlowski RZ, Arnao M, Lonial S, Karanes C, Pawlyn C, Kim K, Oriol A, Berdeja JG, Rodríguez Otero P, Casas-Avilés I, Spirli A, Poon J, Li S, Gong J, Wong L, Lamba M, Pierce DW, Amatangelo M, Peluso T, Maciag P, Katz J, Pourdehnad M, Bahlis NJ, CC-92480-MM-001 Study Investigators. PMID: 37646702.
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22 Fields:
Translation:
CTClinical Trials
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Phase Ib study of avadomide (CC-122) in combination with rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma. EJHaem. 2022 May; 3(2):394-405.
Nastoupil LJ, Kuruvilla J, Chavez JC, Bijou F, Witzig TE, Santoro A, Flinn IW, Boccomini C, Kenkre VP, Corradini P, Isufi I, Andorsky DJ, Klein LM, Greenwald DR, Sangha R, Shen F, Hagner P, Li Y, Dobmeyer J, Gong N, Uttamsingh S, Pourdehnad M, Ribrag V. PMID: 35846031; PMCID: PMC9175947.
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5
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Correction to: Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies. AAPS J. 2022 Jan 14; 24(1):29.
Abbiati RA, Pourdehnad M, Carrancio S, Pierce DW, Kasibhatla S, McConnell M, Trotter MWB, Loos R, Santini CC, Ratushny AV. PMID: 35038051; PMCID: PMC9172776.
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Phase Ib study of combinations of avadomide (CC-122), CC-223, CC-292, and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma. EJHaem. 2022 Feb; 3(1):139-153.
Ribrag V, Chavez JC, Boccomini C, Kaplan J, Chandler JC, Santoro A, Corradini P, Flinn IW, Advani R, Cassier PA, Sangha R, Kenkre VP, Isufi I, Uttamsingh S, Hagner PR, Gandhi AK, Shen F, Michelliza S, Haeske H, Hege K, Pourdehnad M, Kuruvilla J. PMID: 35846221; PMCID: PMC9176062.
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PubMed Mentions:
3
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Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies. AAPS J. 2021 08 27; 23(5):103.
Abbiati RA, Pourdehnad M, Carrancio S, Pierce DW, Kasibhatla S, McConnell M, Trotter MWB, Loos R, Santini CC, Ratushny AV. PMID: 34453265; PMCID: PMC8397660.
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1 Fields:
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HumansCells
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Population Pharmacokinetics of CC-122. Clin Pharmacol. 2021; 13:61-71.
Cheng Y, Chen J, Pourdehnad M, Zhou S, Li Y. PMID: 33958900; PMCID: PMC8093142.
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CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 02 25; 64(4):1835-1843.
Hansen JD, Correa M, Alexander M, Nagy M, Huang D, Sapienza J, Lu G, LeBrun LA, Cathers BE, Zhang W, Tang Y, Ammirante M, Narla RK, Piccotti JR, Pourdehnad M, Lopez-Girona A. PMID: 33591756.
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34 Fields:
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HumansAnimalsCells
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CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 02 04; 137(5):661-677.
Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, Fontanillo C, Tran E, Contreras A, Ng SWK, Matyskiela M, Wang K, Chamberlain P, Cathers B, Carmichael J, Hansen J, Wang JCY, Minden MD, Fan J, Pierce DW, Pourdehnad M, Rolfe M, Lopez-Girona A, Dick JE, Lu G. PMID: 33197925; PMCID: PMC8215192.
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56 Fields:
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HumansAnimalsCells
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Phase I, multicenter, dose-escalation study of avadomide in adult Japanese patients with advanced malignancies. Cancer Sci. 2021 Jan; 112(1):331-338.
Hatake K, Chou T, Doi T, Terui Y, Kato H, Hirose T, Seo S, Pourdehnad M, Ogaki Y, Fujimoto H, Hagner PR, Yamamoto K. PMID: 33075165; PMCID: PMC7780008.
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PubMed Mentions:
5 Fields:
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HumansCTClinical Trials
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Avadomide plus obinutuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (CC-122-NHL-001): a multicentre, dose escalation and expansion phase 1 study. Lancet Haematol. 2020 Sep; 7(9):e649-e659.
Michot JM, Bouabdallah R, Vitolo U, Doorduijn JK, Salles G, Chiappella A, Zinzani PL, Bijou F, Kersten MJ, Sarmiento R, Mosulen S, Mendez C, Uttamsingh S, Pourdehnad M, Hege K, Chen T, Klein C, Hagner PR, Nikolova Z, Ribrag V. PMID: 32758434.
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12 Fields:
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HumansCTClinical Trials
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Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier. Blood. 2020 03 26; 135(13):996-1007.
Carpio C, Bouabdallah R, Ysebaert L, Sancho JM, Salles G, Cordoba R, Pinto A, Gharibo M, Rasco D, Panizo C, Lopez-Martin JA, Santoro A, Salar A, Damian S, Martin A, Verhoef G, Van den Neste E, Wang M, Couto S, Carrancio S, Weng A, Wang X, Schmitz F, Wei X, Hege K, Trotter MWB, Risueño A, Buchholz TJ, Hagner PR, Gandhi AK, Pourdehnad M, Ribrag V. PMID: 31977002; PMCID: PMC7099331.
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33 Fields:
Translation:
HumansCells
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Leveraging gene expression subgroups to classify DLBCL patients and select for clinical benefit from a novel agent. Blood. 2020 03 26; 135(13):1008-1018.
Risueño A, Hagner PR, Towfic F, Fontanillo C, Djebbari A, Parker JS, Drew CP, Nowakowski GS, Maurer MJ, Cerhan JR, Wei X, Ren Y, Lee CW, Couto S, Wang M, Pourdehnad M, Gandhi AK, Trotter MWB. PMID: 31977005; PMCID: PMC7099333.
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14 Fields:
Translation:
HumansCells
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A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 01 01; 25(1):90-98.
Rasco DW, Papadopoulos KP, Pourdehnad M, Gandhi AK, Hagner PR, Li Y, Wei X, Chopra R, Hege K, DiMartino J, Shih K. PMID: 30201761.
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PubMed Mentions:
49 Fields:
Translation:
CTClinical Trials
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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL. Blood. 2015 Aug 06; 126(6):779-89.
Hagner PR, Man HW, Fontanillo C, Wang M, Couto S, Breider M, Bjorklund C, Havens CG, Lu G, Rychak E, Raymon H, Narla RK, Barnes L, Khambatta G, Chiu H, Kosek J, Kang J, Amantangelo MD, Waldman M, Lopez-Girona A, Cai T, Pourdehnad M, Trotter M, Daniel TO, Schafer PH, Klippel A, Thakurta A, Chopra R, Gandhi AK. PMID: 26002965; PMCID: PMC4528065.
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79 Fields:
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CTClinical Trials
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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93.
Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. PMID: 23803853; PMCID: PMC3718086.
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145 Fields:
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HumansAnimalsCells
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Investigating Myc-dependent translational regulation in normal and cancer cells. Methods Mol Biol. 2013; 1012:201-12.
Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D. PMID: 24006066; PMCID: PMC4390065.
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PubMed Mentions:
4 Fields:
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HumansCells
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Reduced grey matter metabolism due to white matter edema allows optimal assessment of brain tumors on 18F-FDG-PET. Hell J Nucl Med. 2011 Sep-Dec; 14(3):219-23.
Pourdehnad M, Basu S, Duarte P, Okpaku AS, Saboury B, Hustinx R, Alavi A. PMID: 22087438.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Stability of cerebral blood flow measures using a split-dose technique with (99m)Tc-exametazime SPECT. Nucl Med Commun. 2005 May; 26(5):475-8.
Newberg AB, Saffer J, Farrar J, Pourdehnad M, Alavi A. PMID: 15838432.
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PubMed Mentions:
1 Fields:
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Humans
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18F-FDG PET in malignant lymphoma: significance of positive findings. Eur J Nucl Med Mol Imaging. 2005 Jul; 32(7):749-56.
Castellucci P, Zinzani P, Pourdehnad M, Alinari L, Nanni C, Farsad M, Battista G, Tani M, Stefoni V, Canini R, Monetti N, Rubello D, Alavi A, Franchi R, Fanti S. PMID: 15785956.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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PET imaging for differentiating recurrent brain tumor from radiation necrosis. Radiol Clin North Am. 2005 Jan; 43(1):35-47.
Hustinx R, Pourdehnad M, Kaschten B, Alavi A. PMID: 15693646.
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PubMed Mentions:
26 Fields:
Translation:
HumansPHPublic Health
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Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004 May; 68(1):1-9.
Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS. PMID: 15174514.
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PubMed Mentions:
39 Fields:
Translation:
Animals
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Synthesis and evaluation of fluorine-18 labeled glyburide analogs as beta-cell imaging agents. Nucl Med Biol. 2004 May; 31(4):483-91.
Schmitz A, Shiue CY, Feng Q, Shiue GG, Deng S, Pourdehnad MT, Schirrmacher R, Vatamaniuk M, Doliba N, Matschinsky F, Wolf B, Rösch F, Naji A, Alavi AA. PMID: 15093819.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Cerebral blood flow during meditative prayer: preliminary findings and methodological issues. Percept Mot Skills. 2003 Oct; 97(2):625-30.
Newberg A, Pourdehnad M, Alavi A, d'Aquili EG. PMID: 14620252.
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32 Fields:
Translation:
Humans
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Do high glucose levels have differential effect on FDG uptake in inflammatory and malignant disorders? Nucl Med Commun. 2001 Oct; 22(10):1123-8.
Zhuang HM, Cortés-Blanco A, Pourdehnad M, Adam LE, Yamamoto AJ, Martínez-Lázaro R, Lee JH, Loman JC, Rossman MD, Alavi A. PMID: 11567186.
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23 Fields:
Translation:
HumansCells
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Inter-modality comparisons of seizure focus lateralization in complex partial seizures. Eur J Nucl Med. 2001 Oct; 28(10):1529-40.
Meyer PT, Cortés-Blanco A, Pourdehnad M, Levy-Reis I, Desiderio L, Jang S, Alavi A. PMID: 11685497.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes. J Nucl Med. 2001 Sep; 42(9):1412-7.
Zhuang H, Pourdehnad M, Lambright ES, Yamamoto AJ, Lanuti M, Li P, Mozley PD, Rossman MD, Albelda SM, Alavi A. PMID: 11535734.
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PubMed Mentions:
169 Fields:
Translation:
HumansAnimalsCells
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Similar pelvic abnormalities on FDG positron emission tomography of different origins. Clin Nucl Med. 2001 Jun; 26(6):515-7.
Zhuang H, Yamamoto AJ, Sinha P, Pourdehnad M, Liu Y, Alavi A. PMID: 11353298.
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Humans
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Intense F-18 fluorodeoxyglucose uptake caused by mycobacterium avium intracellulare infection. Clin Nucl Med. 2001 May; 26(5):458.
Zhuang H, Pourdehnad M, Yamamoto AJ, Rossman MD, Alavi A. PMID: 11317033.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The measurement of regional cerebral blood flow during the complex cognitive task of meditation: a preliminary SPECT study. Psychiatry Res. 2001 Apr 10; 106(2):113-22.
Newberg A, Alavi A, Baime M, Pourdehnad M, Santanna J, d'Aquili E. PMID: 11306250.
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PubMed Mentions:
66 Fields:
Translation:
Humans
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The promising role of 18F-FDG PET in detecting infected lower limb prosthesis implants. J Nucl Med. 2001 Jan; 42(1):44-8.
Zhuang H, Duarte PS, Pourdehnad M, Maes A, Van Acker F, Shnier D, Garino JP, Fitzgerald RH, Alavi A. PMID: 11197979.
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PubMed Mentions:
45 Fields:
Translation:
Humans
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The role of positron emission tomography with fluorine-18-deoxyglucose in identifying colorectal cancer metastases to liver. Nucl Med Commun. 2000 Sep; 21(9):793-8.
Zhuang H, Sinha P, Pourdehnad M, Duarte PS, Yamamoto AJ, Alavi A. PMID: 11065150.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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26. Incidental findings should be included in the analysis of cost-effectiveness for evaluation of pulmonary nodules by FDG-PET. Clin Positron Imaging. 2000 Jul; 3(4):180.
Zhuang HM, Duarte P, Pourdehnad M, Yamamoto AJ, Loman JC, Sinha P, Alavi A. PMID: 11150783.
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PubMed Mentions:
1
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Gastric emptying of solids: estimates of lag phase and constant emptying times. Nucl Med Commun. 2000 Jul; 21(7):665-75.
Couturier O, Le Rest C, Gournay J, Pourdehnad M, Bridji B, Turzo A, Bizais Y. PMID: 10994671.
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PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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Standardized uptake value as an unreliable index of renal disease on fluorodeoxyglucose PET imaging. Clin Nucl Med. 2000 May; 25(5):358-60.
Zhuang H, Duarte PS, Pourdehnad M, Li P, Alavi A. PMID: 10795695.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender. Am J Physiol. 1999 03; 276(3):R707-14.
Teff KL, Alavi A, Chen J, Pourdehnad M, Townsend RR. PMID: 10070130.
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PubMed Mentions:
12 Fields:
Translation:
HumansCTClinical Trials
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Effects of development of host immunity on the biodistribution of xenogeneic MHC non-restricted cytotoxic T cells: implications for adoptive cell therapy of cancer. Int J Oncol. 1999 Feb; 14(2):233-44.
Cesano A, Wortman JA, Pourdehnad M, Visonneau S, Mozley D, Bhatnagar A, Alavi A, Santoli D. PMID: 9917497.
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Translation:
HumansAnimalsCells