Loading...

Davide Ruggero, PhD

Title(s)Professor, Urology
SchoolSchool of Medicine
Phone415-514-9755
ORCID ORCID Icon0000-0002-9444-5865 Additional info
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of regulated translation control in cancer and its therapeutic implications
    NIH/NCI R35CA242986Aug 6, 2019 - Jul 31, 2026
    Role: Principal Investigator
    MYCN, mTOR and translation control in medulloblastoma
    NIH/NINDS R01NS089868Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    X-linked Dyskeratosis Congenita and ribosomal frameshifting
    NIH/NHLBI R01HL119439Aug 1, 2014 - Apr 30, 2018
    Role: Co-Principal Investigator
    elF4E-Dependent Translation Control in the Oncogenic Stress Response and Cancer
    NIH/NCI R01CA184624May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Deciphering the role of the translational oncogenic program in Prostate Cancer
    NIH/NCI R01CA154916Sep 1, 2011 - Jun 30, 2022
    Role: Principal Investigator
    Delineating the Mechanisms Responsible for Synthetic Lethality in MYC-induced Tumorigenesis Driven by Control of Protein Synthesis
    NIH/NCI R01CA140456Jul 1, 2009 - Apr 30, 2020
    Role: Principal Investigator
    Role of ribosome impairments in X-linked Dyskeratosis Congenita pathogenesis
    NIH/NIDDK R01DK098057Aug 1, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Role of rRNA Modifications in Dyskeratosis Congenita and Translation Control
    NIH/NHLBI R01HL085572Aug 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yichen Xu, Davide Ruggero. The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications. Annual Review of Cancer Biology. 2020 Mar 4; 4(1):1-21.
      View in: Publisher Site
    2. Wei J, Leung K, Truillet C, Ruggero D, Wells J, Evans MJ. Profiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling. Mol Cell Proteomics. 2019 Dec 02. PMID: 31792071.
      View in: PubMed
    3. McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. Elife. 2019 09 03; 8. PMID: 31478838.
      View in: PubMed
    4. Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C. Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 2019 Aug; 21(8):1052. PMID: 31316187.
      View in: PubMed
    5. Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H. Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay. Mol Cell. 2019 Sep 05; 75(5):967-981.e9. PMID: 31300274.
      View in: PubMed
    6. Robichaud N, Sonenberg N, Ruggero D, Schneider RJ. Translational Control in Cancer. Cold Spring Harb Perspect Biol. 2019 Jul 01; 11(7). PMID: 29959193.
      View in: PubMed
    7. Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 2019 07; 21(7):889-899. PMID: 31263264.
      View in: PubMed
    8. Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Cent Sci. 2019 Apr 24; 5(4):727-736. PMID: 31041393.
      View in: PubMed
    9. Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host Microbe. 2019 03 13; 25(3):454-462.e6. PMID: 30827827.
      View in: PubMed
    10. Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 02; 25(2):301-311. PMID: 30643286.
      View in: PubMed
    11. Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA. The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes. J Immunol. 2019 01 15; 202(2):579-590. PMID: 30530594.
      View in: PubMed
    12. McMahon M, Ruggero D. A Translation Tuning HuDdle for Neurons. Mol Cell. 2018 07 19; 71(2):195-196. PMID: 30028999.
      View in: PubMed
    13. McMahon M, Ruggero D. A wobbly road to drug resistance in melanoma: tRNA-modifying enzymes in translation reprogramming. EMBO J. 2018 08 01; 37(15). PMID: 29967029.
      View in: PubMed
    14. Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 05 02; 10(439). PMID: 29720449.
      View in: PubMed
    15. Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL. Revealing nascent proteomics in signaling pathways and cell differentiation. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2353-2358. PMID: 29467287.
      View in: PubMed
    16. Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018 01 08; 33(1):91-107.e6. PMID: 29316436.
      View in: PubMed
    17. Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018 01; 20(1):104-115. PMID: 29230015.
      View in: PubMed
    18. Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss. CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi58-vi58.
      View in: Publisher Site
    19. Truitt ML, Ruggero D. New frontiers in translational control of the cancer genome. Nat Rev Cancer. 2017 04 24; 17(5):332. PMID: 28436470.
      View in: PubMed
    20. Ruggero D, Shaw RJ. Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers. Curr Opin Cell Biol. 2017 04; 45:iv-vi. PMID: 28641761.
      View in: PubMed
    21. Truillet C, Cunningham JT, Parker MFL, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ. Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin. Clin Cancer Res. 2017 Jun 15; 23(12):3045-3052. PMID: 28007777.
      View in: PubMed
    22. So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Sci Signal. 2016 05 31; 9(430):ra57. PMID: 27245614.
      View in: PubMed
    23. Truitt ML, Ruggero D. New frontiers in translational control of the cancer genome. Nat Rev Cancer. 2016 04 26; 16(5):288-304. PMID: 27112207.
      View in: PubMed
    24. Amy Y. Chang, Steven C. Chen, Morgan L. Truitt, Davide Ruggero, Wallace F. Marshall. Automated High-Throughput Quantification Reveals Morphological Heterogeneity in Mammalian Cell Populations. Biophysical Journal. 2016 Feb 1; 110(3):317a.
      View in: Publisher Site
    25. Craig M Forester, Zhen Shi, Maria Barna, Davide Ruggero. A Tailor-Made Protein Synthesis Program Drives Erythroid Development and Disease. Blood. 2015 Dec 3; 126(23):3581-3581.
      View in: Publisher Site
    26. Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero D. Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors. Sci Signal. 2015 Nov 17; 8(403):ra116. PMID: 26577921.
      View in: PubMed
    27. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 02; 162(1):59-71. PMID: 26095252.
      View in: PubMed
    28. Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Res. 2015 Jul 15; 75(14):2851-62. PMID: 25977330.
      View in: PubMed
    29. Sheridan CM, Grogan TR, Nguyen HG, Galet C, Rettig MB, Hsieh AC, Ruggero D. YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence. Oncotarget. 2015 Apr 10; 6(10):7470-80. PMID: 25797255.
      View in: PubMed
    30. Pelletier J, Graff J, Ruggero D, Sonenberg N. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res. 2015 Jan 15; 75(2):250-63. PMID: 25593033.
      View in: PubMed
    31. Antonio R Lucena-Araujo, Bárbara A Santana-Lemos, Carol H Thome, Germano A Ferreira, Davide Ruggero, Vitor Marcel Faça, Eduardo M Rego. Early Hematopoietic Progenitors of Dkc1 Hypomorphic Mutant Mice Display Decreased Proliferation Rate and an Impaired Control of Serine/Arginine-Rich Splicing Factor 4 (Srsf4) Translation. Blood. 2014 Dec 6; 124(21):2937-2937.
      View in: Publisher Site
    32. McMahon M, Contreras A, Ruggero D. Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. Wiley Interdiscip Rev RNA. 2015 Mar-Apr; 6(2):173-89. PMID: 25363811.
      View in: PubMed
    33. Ruggero D, Shimamura A. Marrow failure: a window into ribosome biology. Blood. 2014 Oct 30; 124(18):2784-92. PMID: 25237201.
      View in: PubMed
    34. John T. Cunningham, Melissa V. Moreno, Alessia Lodi, Sabrina M. Ronen, Davide Ruggero. Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. Cell. 2014 Jul 1; 158(3):689.
      View in: Publisher Site
    35. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 2014 May 22; 157(5):1088-103. PMID: 24855946.
      View in: PubMed
    36. Barna M, Ruggero D. Tailor made protein synthesis for HSCs. Cell Stem Cell. 2014 Apr 03; 14(4):423-4. PMID: 24702992.
      View in: PubMed
    37. Yoshinori Tsukumo, Mathieu Laplante, Armen Parsyan, Davide Ruggero, Bruno Fonseca. mTOR and Regulation of Translation. Translation and Its Regulation in Cancer Biology and Medicine. 2014 Jan 1; 307-343.
      View in: Publisher Site
    38. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2014 Jan; 11(1):86-93. PMID: 24213167.
      View in: PubMed
    39. Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D. The translational landscape of the mammalian cell cycle. Mol Cell. 2013 Nov 21; 52(4):574-82. PMID: 24120665.
      View in: PubMed
    40. Cunningham JT, Ruggero D. New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization. Cancer Discov. 2013 Oct; 3(10):1099-102. PMID: 24124229.
      View in: PubMed
    41. Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS. Assessing gene-level translational control from ribosome profiling. Bioinformatics. 2013 Dec 01; 29(23):2995-3002. PMID: 24048356.
      View in: PubMed
    42. Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93. PMID: 23803853.
      View in: PubMed
    43. Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D. H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. Cell Rep. 2013 May 30; 3(5):1493-502. PMID: 23707062.
      View in: PubMed
    44. Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR. Common variable immunodeficiency as the initial presentation of dyskeratosis congenita. J Allergy Clin Immunol. 2013 Jul; 132(1):223-6. PMID: 23403051.
      View in: PubMed
    45. Ruggero D. Translational control in cancer etiology. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). PMID: 22767671.
      View in: PubMed
    46. Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D. Investigating Myc-dependent translational regulation in normal and cancer cells. Methods Mol Biol. 2013; 1012:201-12. PMID: 24006066.
      View in: PubMed
    47. Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature. 2013 Jan 17; 493(7432):411-5. PMID: 23263185.
      View in: PubMed
    48. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17; 493(7432):371-7. PMID: 23172145.
      View in: PubMed
    49. Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Dec; 122(12):4621-34. PMID: 23143306.
      View in: PubMed
    50. Davide Ruggero. Translational Control in Cancer Etiology. Cold Spring Harbor Perspectives in Biology. 2012 Nov 1; 4(11):a015891.
      View in: Publisher Site
    51. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. PMID: 23042294.
      View in: PubMed
    52. Ruggero D. Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal. 2012 Sep 11; 5(241):pe38. PMID: 22969157.
      View in: PubMed
    53. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22; 485(7396):55-61. PMID: 22367541.
      View in: PubMed
    54. Mary McMahon, Cristian Bellodi, Davide Ruggero. The “Fifth” RNA Nucleotide: A Role for Ribosomal RNA Pseudouridylation in Control of Gene Expression at the Translational Level. Biophysical approaches to translational control of gene expression. 2012 Jan 1; 253-288.
      View in: Publisher Site
    55. Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol Cell. 2011 Nov 18; 44(4):660-6. PMID: 22099312.
      View in: PubMed
    56. Hsieh AC, Truitt ML, Ruggero D. Oncogenic AKTivation of translation as a therapeutic target. Br J Cancer. 2011 Jul 26; 105(3):329-36. PMID: 21772331.
      View in: PubMed
    57. Stumpf CR, Ruggero D. The cancerous translation apparatus. Curr Opin Genet Dev. 2011 Aug; 21(4):474-83. PMID: 21543223.
      View in: PubMed
    58. Hsieh AC, Ruggero D. Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer. Clin Cancer Res. 2010 Oct 15; 16(20):4914-20. PMID: 20702611.
      View in: PubMed
    59. Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D. Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res. 2010 Jul 15; 70(14):6026-35. PMID: 20587522.
      View in: PubMed
    60. Bellodi C, Kopmar N, Ruggero D. Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita. EMBO J. 2010 Jun 02; 29(11):1865-76. PMID: 20453831.
      View in: PubMed
    61. Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010 Mar 16; 17(3):249-61. PMID: 20227039.
      View in: PubMed
    62. Ruggero D. The role of Myc-induced protein synthesis in cancer. Cancer Res. 2009 Dec 01; 69(23):8839-43. PMID: 19934336.
      View in: PubMed
    63. Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii, David Lyden, J. Wels. Kaplan et al. reply. Nature. 2009 Sep 1; 461(7262):e5-e5.
      View in: Publisher Site
    64. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10; 7(2):e38. PMID: 19209957.
      View in: PubMed
    65. Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature. 2008 Dec 18; 456(7224):971-5. PMID: 19011615.
      View in: PubMed
    66. D. Ruggero, A. Yoon, G. Peng, O. Zollo, R. Adamo, N. Haynes, W. Xu, E. Rego. 130 INVITED Novel insight into the pathogenesis of dyskeratosis congenita: how defective ribosome activity can cause cancer and disease. European Journal of Cancer Supplements. 2007 Sep 1; 5(4):35-36.
      View in: Publisher Site
    67. Yoon A, Peng G, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science. 2006 May 12; 312(5775):902-6. PMID: 16690864.
      View in: PubMed
    68. Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. 2006 Mar 23; 25(13):1974-9. PMID: 16331271.
      View in: PubMed
    69. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005 Dec 08; 438(7069):820-7. PMID: 16341007.
      View in: PubMed
    70. Ruggero D, Sonenberg N. The Akt of translational control. Oncogene. 2005 Nov 14; 24(50):7426-34. PMID: 16288289.
      View in: PubMed
    71. Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med. 2004 May; 10(5):484-6. PMID: 15098029.
      View in: PubMed
    72. Ruggero D, Pandolfi PP. Does the ribosome translate cancer? Nat Rev Cancer. 2003 Mar; 3(3):179-92. PMID: 12612653.
      View in: PubMed
    73. Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Rao PH, Cordon-Cardo C, Pandolfi PP. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science. 2003 Jan 10; 299(5604):259-62. PMID: 12522253.
      View in: PubMed
    74. Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev Cell. 2002 Oct; 3(4):499-510. PMID: 12408802.
      View in: PubMed
    75. Ruggero D, Wang ZG, Pandolfi PP. The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays. 2000 Sep; 22(9):827-35. PMID: 10944585.
      View in: PubMed
    76. Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med. 2000 Feb 21; 191(4):631-40. PMID: 10684855.
      View in: PubMed
    77. Condò I, Ciammaruconi A, Benelli D, Ruggero D, Londei P. Cis-acting signals controlling translational initiation in the thermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 1999 Oct; 34(2):377-84. PMID: 10564480.
      View in: PubMed
    78. Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP. PML is essential for multiple apoptotic pathways. Nat Genet. 1998 Nov; 20(3):266-72. PMID: 9806545.
      View in: PubMed
    79. Condò I, Ruggero D, Reinhardt R, Londei P. A novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 1998 Aug; 29(3):775-85. PMID: 9723917.
      View in: PubMed
    80. Ruggero D, Ciammaruconi A, Londei P. The chaperonin of the archaeon Sulfolobus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing. EMBO J. 1998 Jun 15; 17(12):3471-7. PMID: 9628882.
      View in: PubMed
    81. Ruggero D, Londei P. Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea. J Bacteriol. 1996 Jun; 178(11):3396-8. PMID: 8655531.
      View in: PubMed
    82. Davide Ruggero, Roberta Creti, Paola Londei. In vitro translation of archaeal natural mRNAs at high temperature. FEMS Microbiology Letters. 1993 Feb 1; 107(1):89-94.
      View in: Publisher Site
    83. Bandini G, Ricci P, Ruggero D, Cantore M, Visani G, Tura S. Lithium and granulocytopenia during induction treatment of adult acute lymphoblastic leukemia. Tumori. 1982 Oct 31; 68(5):427-30. PMID: 6960590.
      View in: PubMed
    84. Speck B, Gratwohl A, Nissen C, Leibundgut U, Ruggero D, Osterwalder B, Burri HP, Cornu P, Jeannet M. Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation. Br Med J (Clin Res Ed). 1981 Mar 14; 282(6267):860-3. PMID: 6783204.
      View in: PubMed
    85. Gratwohl A, Cornu P, Nissen C, Ruggero D, Osterwalder B, Speck B. [Experience with intensive plasma exchange]. Schweiz Med Wochenschr. 1980 Oct 04; 110(40):1449-51. PMID: 7280593.
      View in: PubMed
    86. Bandini G, Ricci P, Baccarani M, Ruggero D, Tura S. Serum lysozyme level in adult acute non-lymphoid leukaemia. Haematologica. 1979 Jun; 64(3):288-95. PMID: 113297.
      View in: PubMed
    87. Ruggero D, Baccarani M, Gobbi M, Tura S. Adult acute lymphoblastic leukaemia: study of 32 patients and analysis of prognostic factors. Scand J Haematol. 1979 Feb; 22(2):154-64. PMID: 311937.
      View in: PubMed
    88. Baccarani M, Ruggero D, Gobbi M, Tura S. Sex and prognosis in adult acute lymphoblastic leukaemia. Br Med J. 1978 Dec 09; 2(6152):1646. PMID: 281982.
      View in: PubMed
    89. Zaccaria A, Ruggero D, Guolo ML, Guarini A, Frezza R, Baccarani M, Tura S. Ph1-positive chronic myeloid leukaemia presenting in blastic crisis: report of 12 cases. Boll Ist Sieroter Milan. 1978 Jul 31; 57(3):383-91. PMID: 282907.
      View in: PubMed
    90. Baccarani M, Ruggero D, Tura S. Therapy of chronic myeloid leukemia (CML): interim report on protocols CML/73 and CML/74. Boll Ist Sieroter Milan. 1978 Jul 31; 57(3):278-88. PMID: 367386.
      View in: PubMed
    91. Gobbi M, Ruggero D, Baccarani M, Zaccaria A, Tomasini I, Tura S. Immunotherapy with BCG and leukemic blast cells during complete remission of acute myeloid leukemia. Haematologica. 1977 Oct; 62(5):529-36. PMID: 412739.
      View in: PubMed
    92. Ruggero D, Baccarani M, Zaccaria A, Gobbi M, Tomasini I, Tura S. Nervous system involvement in adult acute myeloid leukaemia: report of five cases. Haematologica. 1977 Jun; 62(3):312-9. PMID: 408244.
      View in: PubMed
    93. Gobbi M, Fiacchini M, Tomasini I, Ruggero D, Lauria F, Tura S. Immunological study of patients with Hodgkin's disease in long-lasting not-maintained complete remission. Boll Ist Sieroter Milan. 1977 Mar 31; 56(2):144-51. PMID: 326273.
      View in: PubMed
    94. Ruggero D, Baccarani M, Guarini A, Gugliotta L, Gobbi M, Ricci P, Zaccaria A, Lauria F, Tomasini I, Fiacchini M, Santucci MA, Tura S. Acute promyelocytic leukemia: results of therapy and analysis of 13 cases. Acta Haematol. 1977; 58(2):108-19. PMID: 409019.
      View in: PubMed
    95. Ruggero D, Baccarani M, Tomasini I, Gobbi M, Santucci MA, Guarini A, Tura S. [Progress and problems in the treatment of acute myeloid leukemia: analysis of 92 cases]. G Clin Med. 1976 Sep-Oct; 57(9-10):283-97. PMID: 1072018.
      View in: PubMed
    96. Fiacchini M, Ruggero D, Tomasini I, Sciascia R, Emiliani E, Babini L. ["Cured" Hodgkin's disease in a retrospective study of 147 cases]. G Clin Med. 1976 Mar-Aug; 57(5-6):167-82. PMID: 1010166.
      View in: PubMed
    97. Tura S, Ruggero D. [Antibiotic therapy in the high risk patient (hematologic study)]. G Clin Med. 1976 Mar-Apr; 57(3-4):92-104. PMID: 1001857.
      View in: PubMed
    98. Baccarani M, Zaccaria A, Santucci AM, Bagnara GP, Ricci P, Gobbi M, Ruggero D, Brunelli MA, Tura S. A simultaneous study of bone marrow, spleen, and liver in chronic myeloid leukemia: evidence for differences in cell composition and karyotypes. Ser Haematol. 1975; 8(4):81-112. PMID: 1071286.
      View in: PubMed