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Davide Ruggero, PhD

Title(s)Professor, Urology
SchoolSchool of Medicine
Address1450 3rd Street
San Francisco CA 94158
Phone415-514-9755
ORCID ORCID Icon0000-0002-9444-5865 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Rome, La Sapienza, ItalyB.S.1994Biology
    University of Rome, La Sapienza, ItalyPh.D.1998Molecular and Cell Biology
    Collapse Awards and Honors
    1994Enichem Society Fellowship
    1998  - 2000American-Italian Cancer Foundation Fellowship
    2003Outstanding Research Fellow Award at MSKCC
    2005  - 2007V Foundation Scholar Award
    2006  - 2007Pennsylvania Department of Health Merit Award (Commonwealth Universal Research Enhancement Program)
    2008AACR Gertrude B. Elion Cancer Research Award
    2010Leukemia & Lymphoma Society Scholar Award
    2010Phi Beta Psi Sorority National Project Research Award
    2010UCSF Program for Breakthrough Biomedical Research Award
    2010Co-Chair and Organizer, 1st American Association for Cancer Research "Protein Translation and Cancer
    2011Helen Diller Family Endowed Chair of Basic Cancer Research
    2013Co-Organizer, AACR 3rd International Conference on Frontiers in Basic Cancer Research
    2013Chair, 2013 AACR Annual Meeting Major Symposium on "Stress Response Pathways in Cancer"
    2016Co-Chair and Organizer, AACR Special Conference on "Translating the cancer genome: a new frontier in
    2017Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther
    2017Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther
    2017Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther
    2017Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther
    2017Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther
    2018Co-Chair, 2018 Cold Spring Harbor Laboratories Meeting on Translational Control
    2019Chair, NCI Special Workshop on Dysregulation of Ribosome Biogenesis & Protein Synthesis in Cancer
    2019NCI Outstanding Investigator Award (R35)
    2019American Cancer Society (ACS) Research Professorship Award
    2020Co-Organizer, ACS “Expanding the Central Dogma to Fight Cancer” Symposium
    2020Co-Organizer, QBI Cancer Cell Symposium

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of regulated translation control in cancer and its therapeutic implications
    NIH/NCI R35CA242986Aug 6, 2019 - Jul 31, 2026
    Role: Principal Investigator
    MYCN, mTOR and translation control in medulloblastoma
    NIH/NINDS R01NS089868Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    X-linked Dyskeratosis Congenita and ribosomal frameshifting
    NIH/NHLBI R01HL119439Aug 1, 2014 - Apr 30, 2018
    Role: Co-Principal Investigator
    elF4E-Dependent Translation Control in the Oncogenic Stress Response and Cancer
    NIH/NCI R01CA184624May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Deciphering the role of the translational oncogenic program in Prostate Cancer
    NIH/NCI R01CA154916Sep 1, 2011 - Jun 30, 2022
    Role: Principal Investigator
    Delineating the Mechanisms Responsible for Synthetic Lethality in MYC-induced Tumorigenesis Driven by Control of Protein Synthesis
    NIH/NCI R01CA140456Jul 1, 2009 - Apr 30, 2020
    Role: Principal Investigator
    Role of ribosome impairments in X-linked Dyskeratosis Congenita pathogenesis
    NIH/NIDDK R01DK098057Aug 1, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Role of rRNA Modifications in Dyskeratosis Congenita and Translation Control
    NIH/NHLBI R01HL085572Aug 1, 2006 - May 31, 2011
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Apr 30. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 27     Fields:    
    2. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329.
      View in: PubMed   Mentions:
    3. The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications. Annual Review of Cancer Biology. 2020 Mar 4; 4(1):1-21. Yichen Xu, Davide Ruggero. .
      View in: Publisher Site   Mentions:
    4. Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. Mol Cell Proteomics. 2020 02; 19(2):294-307. Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. PMID: 31792071.
      View in: PubMed   Mentions:    Fields:    
    5. Regulation of eIF4E Guides a Unique Translational Program to Steer Erythroid Maturation. Blood. 2019 Nov 13; 134(Supplement_1):156-156. Craig M Forester, Gun Woo-Byeon, Juan Oses-Prieto, Al Burlingame, Maria Barna, Davide M Ruggero. .
      View in: Publisher Site   Mentions:
    6. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. Elife. 2019 09 03; 8. McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D. PMID: 31478838.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 2019 Aug; 21(8):1052. Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C. PMID: 31316187.
      View in: PubMed   Mentions: 2     Fields:    
    8. Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay. Mol Cell. 2019 09 05; 75(5):967-981.e9. Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H. PMID: 31300274.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Translational Control in Cancer. Cold Spring Harb Perspect Biol. 2019 07 01; 11(7). Robichaud N, Sonenberg N, Ruggero D, Schneider RJ. PMID: 29959193.
      View in: PubMed   Mentions: 9     Fields:    
    10. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 2019 07; 21(7):889-899. Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C. PMID: 31263264.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Cent Sci. 2019 Apr 24; 5(4):727-736. Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ. PMID: 31041393.
      View in: PubMed   Mentions:
    12. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host Microbe. 2019 03 13; 25(3):454-462.e6. Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S. PMID: 30827827.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    13. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 02; 25(2):301-311. Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D. PMID: 30643286.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes. J Immunol. 2019 01 15; 202(2):579-590. Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA. PMID: 30530594.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. A Translation Tuning HuDdle for Neurons. Mol Cell. 2018 07 19; 71(2):195-196. McMahon M, Ruggero D. PMID: 30028999.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. A wobbly road to drug resistance in melanoma: tRNA-modifying enzymes in translation reprogramming. EMBO J. 2018 08 01; 37(15). McMahon M, Ruggero D. PMID: 29967029.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 05 02; 10(439). Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. PMID: 29720449.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Revealing nascent proteomics in signaling pathways and cell differentiation. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2353-2358. Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL. PMID: 29467287.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018 01 08; 33(1):91-107.e6. Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. PMID: 29316436.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018 01; 20(1):104-115. Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. PMID: 29230015.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    21. CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi58-vi58. Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss. .
      View in: Publisher Site   Mentions:
    22. New frontiers in translational control of the cancer genome. Nat Rev Cancer. 2017 04 24; 17(5):332. Truitt ML, Ruggero D. PMID: 28436470.
      View in: PubMed   Mentions: 6     Fields:    
    23. Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers. Curr Opin Cell Biol. 2017 04; 45:iv-vi. Ruggero D, Shaw RJ. PMID: 28641761.
      View in: PubMed   Mentions:    Fields:    
    24. Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin. Clin Cancer Res. 2017 Jun 15; 23(12):3045-3052. Truillet C, Cunningham JT, Parker MFL, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ. PMID: 28007777.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Sci Signal. 2016 05 31; 9(430):ra57. So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. PMID: 27245614.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. New frontiers in translational control of the cancer genome. Nat Rev Cancer. 2016 04 26; 16(5):288-304. Truitt ML, Ruggero D. PMID: 27112207.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    27. Automated High-Throughput Quantification Reveals Morphological Heterogeneity in Mammalian Cell Populations. Biophysical Journal. 2016 Feb 1; 110(3):317a. Amy Y. Chang, Steven C. Chen, Morgan L. Truitt, Davide Ruggero, Wallace F. Marshall. .
      View in: Publisher Site   Mentions:
    28. A Tailor-Made Protein Synthesis Program Drives Erythroid Development and Disease. Blood. 2015 Dec 3; 126(23):3581-3581. Craig M Forester, Zhen Shi, Maria Barna, Davide Ruggero. .
      View in: Publisher Site   Mentions:
    29. Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors. Sci Signal. 2015 Nov 17; 8(403):ra116. Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero D. PMID: 26577921.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 02; 162(1):59-71. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. PMID: 26095252.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    31. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Res. 2015 Jul 15; 75(14):2851-62. Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. PMID: 25977330.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    32. YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence. Oncotarget. 2015 Apr 10; 6(10):7470-80. Sheridan CM, Grogan TR, Nguyen HG, Galet C, Rettig MB, Hsieh AC, Ruggero D. PMID: 25797255.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    33. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res. 2015 Jan 15; 75(2):250-63. Pelletier J, Graff J, Ruggero D, Sonenberg N. PMID: 25593033.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    34. Early Hematopoietic Progenitors of Dkc1 Hypomorphic Mutant Mice Display Decreased Proliferation Rate and an Impaired Control of Serine/Arginine-Rich Splicing Factor 4 (Srsf4) Translation. Blood. 2014 Dec 6; 124(21):2937-2937. Antonio R Lucena-Araujo, Bárbara A Santana-Lemos, Carol H Thome, Germano A Ferreira, Davide Ruggero, Vitor Marcel Faça, Eduardo M Rego. .
      View in: Publisher Site   Mentions:
    35. Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. Wiley Interdiscip Rev RNA. 2015 Mar-Apr; 6(2):173-89. McMahon M, Contreras A, Ruggero D. PMID: 25363811.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    36. Marrow failure: a window into ribosome biology. Blood. 2014 Oct 30; 124(18):2784-92. Ruggero D, Shimamura A. PMID: 25237201.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. Cell. 2014 Jul 1; 158(3):689. John T. Cunningham, Melissa V. Moreno, Alessia Lodi, Sabrina M. Ronen, Davide Ruggero. .
      View in: Publisher Site   Mentions:
    38. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 2014 May 22; 157(5):1088-103. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. PMID: 24855946.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    39. Tailor made protein synthesis for HSCs. Cell Stem Cell. 2014 Apr 03; 14(4):423-4. Barna M, Ruggero D. PMID: 24702992.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    40. mTOR and Regulation of Translation. Translation and Its Regulation in Cancer Biology and Medicine. 2014 Jan 1; 307-343. Yoshinori Tsukumo, Mathieu Laplante, Armen Parsyan, Davide Ruggero, Bruno Fonseca. .
      View in: Publisher Site   Mentions:
    41. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2014 Jan; 11(1):86-93. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. PMID: 24213167.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. The translational landscape of the mammalian cell cycle. Mol Cell. 2013 Nov 21; 52(4):574-82. Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D. PMID: 24120665.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    43. New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization. Cancer Discov. 2013 Oct; 3(10):1099-102. Cunningham JT, Ruggero D. PMID: 24124229.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    44. Assessing gene-level translational control from ribosome profiling. Bioinformatics. 2013 Dec 01; 29(23):2995-3002. Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS. PMID: 24048356.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    45. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93. Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. PMID: 23803853.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    46. H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. Cell Rep. 2013 May 30; 3(5):1493-502. Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D. PMID: 23707062.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    47. Common variable immunodeficiency as the initial presentation of dyskeratosis congenita. J Allergy Clin Immunol. 2013 Jul; 132(1):223-6. Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR. PMID: 23403051.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Translational control in cancer etiology. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). Ruggero D. PMID: 22767671.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    49. Investigating Myc-dependent translational regulation in normal and cancer cells. Methods Mol Biol. 2013; 1012:201-12. Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D. PMID: 24006066.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    50. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature. 2013 Jan 17; 493(7432):411-5. Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E. PMID: 23263185.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    51. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17; 493(7432):371-7. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. PMID: 23172145.
      View in: PubMed   Mentions: 168     Fields:    Translation:AnimalsCells
    52. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Dec; 122(12):4621-34. Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. PMID: 23143306.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    53. Translational Control in Cancer Etiology. Cold Spring Harbor Perspectives in Biology. 2012 Nov 1; 4(11):a015891. Davide Ruggero. .
      View in: Publisher Site   Mentions:
    54. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. PMID: 23042294.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    55. Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal. 2012 Sep 11; 5(241):pe38. Ruggero D. PMID: 22969157.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    56. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22; 485(7396):55-61. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. PMID: 22367541.
      View in: PubMed   Mentions: 414     Fields:    Translation:HumansAnimalsCells
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