Philip Coffino, MD, PhD

Title(s)Professor Emeritus, Microbiology and Immunology
SchoolSchool of Medicine
Address35 Medical Center Way, #900F
San Francisco CA 94143
ORCID ORCID Icon0000-0003-0344-5083 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Structure of functionally important dynamic states of the proteasome
    NIH R01GM107124Sep 15, 2014 - Aug 31, 2019
    Role: Principal Investigator
    A novel biochemical nanomotor
    NIH R21EB009236May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Energy production and utilization in the proteasome
    NIH R01GM074760Aug 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    NIH R41GM062115Mar 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    NIH R13CA082148Aug 18, 1999 - Jul 31, 2000
    Role: Principal Investigator
    NIH F06TW002274Dec 3, 1998
    Role: Principal Investigator
    Proteasome substrate processing
    NIH R01GM045335Jan 1, 1991 - Jan 31, 2015
    Role: Principal Investigator
    NIH R01CA047721May 1, 1988 - Apr 30, 1992
    Role: Principal Investigator
    NIH R13AG006771Jul 1, 1986 - Jul 31, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    NIH R01CA029048Feb 1, 1982 - Feb 29, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1. Cancer Res. 2024 Jun 18. Shirani M, Levin S, Shebl B, Requena D, Finkelstein TM, Johnson DS, Ng D, Lalazar G, Heissel S, Hojrup P, Molina H, de Jong YP, Rice CM, Singhi AD, Torbenson MS, Coffino P, Lyons B, Simon SM. PMID: 38888469.
      View in: PubMed   Mentions:    Fields:    
    2. Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma. Sci Adv. 2023 06 23; 9(25):eadg7038. Levin SN, Tomasini MD, Knox J, Shirani M, Shebl B, Requena D, Clark J, Heissel S, Alwaseem H, Surjan R, Lahasky R, Molina H, Torbenson MS, Lyons B, Migler RD, Coffino P, Simon SM. PMID: 37343102; PMCID: PMC10284549.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Targeting BCL-XL in fibrolamellar hepatocellular carcinoma. JCI Insight. 2022 09 08; 7(17). Shebl B, Ng D, Lalazar G, Rosemore C, Finkelstein TM, Migler RD, Zheng G, Zhang P, Jiang CS, Qureshi A, Vaughan R, Yarchoan M, de Jong YP, Rice CM, Coffino P, Ortiz MV, Zhou D, Simon SM. PMID: 36073545; PMCID: PMC9536265.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    4. Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA+ ATPase function. J Biol Chem. 2022 10; 298(10):102457. Wang X, Simon SM, Coffino P. PMID: 36064000; PMCID: PMC9531181.
      View in: PubMed   Mentions: 1     Fields:    
    5. Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles. Biomolecules. 2022 05 30; 12(6). Coffino P, Cheng Y. PMID: 35740889; PMCID: PMC9221237.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening. Cancer Discov. 2021 10; 11(10):2544-2563. Lalazar G, Requena D, Ramos-Espiritu L, Ng D, Bhola PD, de Jong YP, Wang R, Narayan NJC, Shebl B, Levin S, Michailidis E, Kabbani M, Vercauteren KOA, Hurley AM, Farber BA, Hammond WJ, Saltsman JA, Weinberg EM, Glickman JF, Lyons BA, Ellison J, Schadde E, Hertl M, Leiting JL, Truty MJ, Smoot RL, Tierney F, Kato T, Wendel HG, LaQuaglia MP, Rice CM, Letai A, Coffino P, Torbenson MS, Ortiz MV, Simon SM. PMID: 34127480; PMCID: PMC8734228.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    7. Allosteric coupling between α-rings of the 20S proteasome. Nat Commun. 2020 09 11; 11(1):4580. Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y. PMID: 32917864; PMCID: PMC7486400.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    8. Slippery substrates impair ATP-dependent protease function by slowing unfolding. J Biol Chem. 2014 Feb 07; 289(6):3826. Coffino P, Too PH, Erales J. PMID: 24510918; PMCID: PMC3916579.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Ubiquitin-independent proteasomal degradation. Biochim Biophys Acta. 2014 Jan; 1843(1):216-21. Erales J, Coffino P. PMID: 23684952; PMCID: PMC3770795.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    10. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. PMID: 23644457; PMCID: PMC3687086.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    11. Slippery substrates impair function of a bacterial protease ATPase by unbalancing translocation versus exit. J Biol Chem. 2013 May 10; 288(19):13243-57. Too PH, Erales J, Simen JD, Marjanovic A, Coffino P. PMID: 23530043; PMCID: PMC3650364.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    12. Ubiquitin proteasome system in stress and disease. Biochem Res Int. 2012; 2012:454796. Karpov D, Glickman MH, Bar-Nun S, Coffino P. PMID: 23227337; PMCID: PMC3513720.
      View in: PubMed   Mentions: 1  
    13. Functional asymmetries of proteasome translocase pore. J Biol Chem. 2012 May 25; 287(22):18535-43. Erales J, Hoyt MA, Troll F, Coffino P. PMID: 22493437; PMCID: PMC3365715.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    14. Dependence of proteasome processing rate on substrate unfolding. J Biol Chem. 2011 May 20; 286(20):17495-502. Henderson A, Erales J, Hoyt MA, Coffino P. PMID: 21454622; PMCID: PMC3093823.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    15. Ordering an engagement ring. Mol Cell. 2010 May 14; 38(3):319-20. Hoyt MA, Coffino P. PMID: 20471937.
      View in: PubMed   Mentions:    Fields:    
    16. Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase. Biochem J. 2008 Mar 01; 410(2):401-7. Takeuchi J, Chen H, Hoyt MA, Coffino P. PMID: 17979831.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    17. A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate. Yeast. 2008 Mar; 25(3):199-217. Hoyt MA, McDonough S, Pimpl SA, Scheel H, Hofmann K, Coffino P. PMID: 18260085.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Proteasome substrate degradation requires association plus extended peptide. EMBO J. 2007 Jan 10; 26(1):123-31. Takeuchi J, Chen H, Coffino P. PMID: 17170706; PMCID: PMC1782366.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    19. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 2007 Jan; 18(1):153-65. Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH. PMID: 17065559; PMCID: PMC1751312.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    20. Glycine-alanine repeats impair proper substrate unfolding by the proteasome. EMBO J. 2006 Apr 19; 25(8):1720-9. Hoyt MA, Zich J, Takeuchi J, Zhang M, Govaerts C, Coffino P. PMID: 16601692; PMCID: PMC1440830.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    21. Probing the ubiquitin/proteasome system with ornithine decarboxylase, a ubiquitin-independent substrate. Methods Enzymol. 2005; 398:399-413. Hoyt MA, Zhang M, Coffino P. PMID: 16275346.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Varshavsky's contributions. Science. 2004 Nov 19; 306(5700):1290-2. Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, Jentsch S, Johnson E, Kwon YT, Pagano M, Pickart C, Rechsteiner M, Scheffner M, Sommer T, Tansey W, Tyers M, Vierstra R, Weissman A, Wilkinson KD, Wolf D. PMID: 15550643.
      View in: PubMed   Mentions:    Fields:    
    23. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science. 2004 Oct 01; 306(5693):117-20. Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. PMID: 15459393.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    24. Development of a method for screening short-lived proteins using green fluorescent protein. Genome Biol. 2004; 5(10):R81. Jiang X, Coffino P, Li X. PMID: 15461799; PMCID: PMC545601.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Ubiquitin-free routes into the proteasome. Cell Mol Life Sci. 2004 Jul; 61(13):1596-600. Hoyt MA, Coffino P. PMID: 15224184.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    26. Proteasomes begin ornithine decarboxylase digestion at the C terminus. J Biol Chem. 2004 May 14; 279(20):20959-65. Zhang M, MacDonald AI, Hoyt MA, Coffino P. PMID: 15016805.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    27. Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome substrate processing. J Biol Chem. 2004 Mar 05; 279(10):8635-41. Zhang M, Coffino P. PMID: 14688254.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    28. Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J. 2003 Apr 01; 22(7):1488-96. Zhang M, Pickart CM, Coffino P. PMID: 12660156; PMCID: PMC152902.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    29. Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. Int J Biochem Cell Biol. 2003 Apr; 35(4):496-521. Auvinen M, Järvinen K, Hotti A, Okkeri J, Laitinen J, Jänne OA, Coffino P, Bergman M, Andersson LC, Alitalo K, Hölttä E. PMID: 12565711.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. Ubiquitin-independent mechanisms of mouse ornithine decarboxylase degradation are conserved between mammalian and fungal cells. J Biol Chem. 2003 Apr 04; 278(14):12135-43. Hoyt MA, Zhang M, Coffino P. PMID: 12562772.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    31. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002 Nov 29; 277(48):45957-61. Chen H, MacDonald A, Coffino P. PMID: 12359729.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    32. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. J Biol Chem. 2002 May 03; 277(18):15486-98. Li Z, Zou CB, Yao Y, Hoyt MA, McDonough S, Mackey ZB, Coffino P, Wang CC. PMID: 11854272.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    33. Regulation of cellular polyamines by antizyme. Nat Rev Mol Cell Biol. 2001 Mar; 2(3):188-94. Coffino P. PMID: 11265248.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimals
    34. Antizyme, a mediator of ubiquitin-independent proteasomal degradation. Biochimie. 2001 Mar-Apr; 83(3-4):319-23. Coffino P. PMID: 11295492.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    35. A homolog of mammalian antizyme is present in fission yeast Schizosaccharomyces pombe but not detected in budding yeast Saccharomyces cerevisiae. Bioinformatics. 2000 May; 16(5):478-81. Zhu C, Karplus K, Grate L, Coffino P. PMID: 10871270.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    36. Polyamines in spermiogenesis: not now, darling. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4421-3. Coffino P. PMID: 10781034; PMCID: PMC34313.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    37. alpha5 subunit in Trypanosoma brucei proteasome can self-assemble to form a cylinder of four stacked heptamer rings. Biochem J. 1999 Dec 01; 344 Pt 2:349-58. Yao Y, Toth CR, Huang L, Wong ML, Dias P, Burlingame AL, Coffino P, Wang CC. PMID: 10567215; PMCID: PMC1220650.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport. J Biol Chem. 1999 Sep 10; 274(37):26425-30. Zhu C, Lang DW, Coffino P. PMID: 10473601.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    39. Regulated degradation of yeast ornithine decarboxylase. J Biol Chem. 1999 Sep 03; 274(36):25921-6. Toth C, Coffino P. PMID: 10464336.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases. Structure. 1999 May; 7(5):567-81. Kern AD, Oliveira MA, Coffino P, Hackert ML. PMID: 10378276.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    41. Developmental effect of polyamine depletion in Caenorhabditis elegans. Biochem J. 1998 Jul 15; 333 ( Pt 2):309-15. MacRae M, Kramer DL, Coffino P. PMID: 9657970; PMCID: PMC1219587.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    42. High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation. J Virol. 1996 Jul; 70(7):4509-16. Li X, Coffino P. PMID: 8676476; PMCID: PMC190386.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    43. Identification of a region of p53 that confers lability. J Biol Chem. 1996 Feb 23; 271(8):4447-51. Li X, Coffino P. PMID: 8626797.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    44. The N terminus of antizyme promotes degradation of heterologous proteins. J Biol Chem. 1996 Feb 23; 271(8):4441-6. Li X, Stebbins B, Hoffman L, Pratt G, Rechsteiner M, Coffino P. PMID: 8626796.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. Crystallization of a mammalian ornithine decarboxylase. Proteins. 1996 Feb; 24(2):266-8. Kern A, Oliveira MA, Chang NL, Ernst SR, Carroll DW, Momany C, Minard K, Coffino P, Hackert ML. PMID: 8820494.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    46. The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis. Genetics. 1995 Jun; 140(2):517-25. Macrae M, Plasterk RH, Coffino P. PMID: 7498733; PMCID: PMC1206631.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Rat antizyme inhibits the activity but does not promote the degradation of mouse ornithine decarboxylase in Trypanosoma brucei. J Biol Chem. 1995 Apr 28; 270(17):10264-71. Hua SB, Li X, Coffino P, Wang CC. PMID: 7730330.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease. Eur J Biochem. 1995 Apr 01; 229(1):276-83. Elias S, Bercovich B, Kahana C, Coffino P, Fischer M, Hilt W, Wolf DH, Ciechanover A. PMID: 7744041.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    49. Distinct domains of antizyme required for binding and proteolysis of ornithine decarboxylase. Mol Cell Biol. 1994 Jan; 14(1):87-92. Li X, Coffino P. PMID: 8264655; PMCID: PMC358359.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    50. Multiple active conformers of mouse ornithine decarboxylase. Biochem J. 1993 Jul 01; 293 ( Pt 1):289-95. Tsirka SE, Turck CW, Coffino P. PMID: 8328969; PMCID: PMC1134353.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein. Mol Cell Biol. 1993 Apr; 13(4):2377-83. Li X, Coffino P. PMID: 8455617; PMCID: PMC359558.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    52. Dominant negative mutants of ornithine decarboxylase. J Biol Chem. 1992 Nov 15; 267(32):23057-62. Tsirka S, Coffino P. PMID: 1429654.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. Role of ornithine decarboxylase suppression and polyamine depletion in the antiproliferative activity of polyamine analogs. Mol Pharmacol. 1992 Aug; 42(2):302-6. Ghoda L, Basu HS, Porter CW, Marton LJ, Coffino P. PMID: 1513327.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme. Mol Cell Biol. 1992 Aug; 12(8):3556-62. Li X, Coffino P. PMID: 1630460; PMCID: PMC364621.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    55. Sequestered end products and enzyme regulation: the case of ornithine decarboxylase. Microbiol Rev. 1992 Jun; 56(2):280-90. Davis RH, Morris DR, Coffino P. PMID: 1620066; PMCID: PMC372868.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    56. Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation. Mol Cell Biol. 1992 May; 12(5):2178-85. Ghoda L, Sidney D, Macrae M, Coffino P. PMID: 1569947; PMCID: PMC364389.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    57. Expression and post-transcriptional regulation of ornithine decarboxylase during early Xenopus development. Eur J Biochem. 1991 Dec 05; 202(2):575-81. Osborne HB, Duval C, Ghoda L, Omilli F, Bassez T, Coffino P. PMID: 1761057.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    58. Killer polyamines? J Cell Biochem. 1991 Jan; 45(1):54-8. Coffino P, Poznanski A. PMID: 2005185.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    59. Ornithine decarboxylase of African trypanosomes. Biochem Soc Trans. 1990 Oct; 18(5):739-40. Ghoda L, Wang CC, Coffino P. PMID: 2083662.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    60. Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation. J Biol Chem. 1990 Jul 15; 265(20):11823-6. Ghoda L, Phillips MA, Bass KE, Wang CC, Coffino P. PMID: 2365702.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    61. Regulation of mouse ornithine decarboxylase activity by cell growth, serum and tetradecanoyl phorbol acetate is governed primarily by sequences within the coding region of the gene. Nucleic Acids Res. 1989 Dec 11; 17(23):9843-60. van Daalen Wetters T, Brabant M, Coffino P. PMID: 2602143; PMCID: PMC335218.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    62. Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational. Mol Cell Biol. 1989 Dec; 9(12):5484-90. van Daalen Wetters T, Macrae M, Brabant M, Sittler A, Coffino P. PMID: 2511435; PMCID: PMC363718.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    63. Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation. Science. 1989 Mar 17; 243(4897):1493-5. Ghoda L, van Daalen Wetters T, Macrae M, Ascherman D, Coffino P. PMID: 2928784.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    64. Trypanosoma brucei ornithine decarboxylase: enzyme purification, characterization, and expression in Escherichia coli. J Biol Chem. 1988 Dec 05; 263(34):17933-41. Phillips MA, Coffino P, Wang CC. PMID: 3056933.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    65. Probable cloning artefacts previously interpreted as unusual leader sequences of rodent ornithine decarboxylase mRNAs--a cautionary tale. Gene. 1988 Sep 30; 69(2):365-8. Coffino P. PMID: 3234772.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    66. Mouse ornithine decarboxylase gene: cloning, structure, and expression. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2200-4. Brabant M, McConlogue L, van Daalen Wetters T, Coffino P. PMID: 3353375; PMCID: PMC279957.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    67. Nucleotide sequence of the mouse ornithine decarboxylase gene. Nucleic Acids Res. 1988 Mar 25; 16(6):2731-2. Coffino P, Chen EL. PMID: 3362685; PMCID: PMC336413.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    68. A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2. Cytogenet Cell Genet. 1988; 48(2):92-4. Cox DR, Trouillot T, Ashley PL, Brabant M, Coffino P. PMID: 3197454.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    69. Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition. J Biol Chem. 1987 Jun 25; 262(18):8721-7. Phillips MA, Coffino P, Wang CC. PMID: 3036823.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    70. Complementation of a polyamine-deficient Escherichia coli mutant by expression of mouse ornithine decarboxylase. Mol Cell Biol. 1987 Jan; 7(1):564-7. Macrae M, Coffino P. PMID: 3550425; PMCID: PMC365106.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    71. Multiple mechanisms are responsible for altered expression of ornithine decarboxylase in overproducing variant cells. Mol Cell Biol. 1986 Aug; 6(8):2865-71. McConlogue L, Dana SL, Coffino P. PMID: 3023951; PMCID: PMC367854.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    72. Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5761-5. Feinstein SC, Dana SL, McConlogue L, Shooter EM, Coffino P. PMID: 3862093; PMCID: PMC390632.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    73. Mouse ornithine decarboxylase. Complete amino acid sequence deduced from cDNA. J Biol Chem. 1985 Mar 10; 260(5):2941-4. Gupta M, Coffino P. PMID: 2982844.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    74. Molecular cloning and expression of the mouse ornithine decarboxylase gene. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):540-4. McConlogue L, Gupta M, Wu L, Coffino P. PMID: 6582509; PMCID: PMC344714.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    75. A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase. J Biol Chem. 1983 Oct 25; 258(20):12083-6. McConlogue L, Coffino P. PMID: 6415048.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    76. Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover. J Biol Chem. 1983 Jul 10; 258(13):8384-8. McConlogue L, Coffino P. PMID: 6408089.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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