Philip Coffino, MD, PhD

Title(s)Professor Emeritus, Microbiology and Immunology
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
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    Structure of functionally important dynamic states of the proteasome
    NIH R01GM107124Sep 15, 2014 - Aug 31, 2019
    Role: Principal Investigator
    A novel biochemical nanomotor
    NIH R21EB009236May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Energy production and utilization in the proteasome
    NIH R01GM074760Aug 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    NIH R41GM062115Mar 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    NIH R13CA082148Aug 18, 1999 - Jul 31, 2000
    Role: Principal Investigator
    NIH F06TW002274Dec 3, 1998
    Role: Principal Investigator
    Proteasome substrate processing
    NIH R01GM045335Jan 1, 1991 - Jan 31, 2015
    Role: Principal Investigator
    NIH R01CA047721May 1, 1988 - Apr 30, 1992
    Role: Principal Investigator
    NIH R13AG006771Jul 1, 1986 - Jul 31, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    NIH R01CA029048Feb 1, 1982 - Feb 29, 1996
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Allosteric coupling between a-rings of the 20S proteasome. Nat Commun. 2020 09 11; 11(1):4580. Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y. PMID: 32917864.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Slippery substrates impair ATP-dependent protease function by slowing unfolding. J Biol Chem. 2014 Feb 07; 289(6):3826. Coffino P, Too PH, Erales J. PMID: 24510918.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Ubiquitin-independent proteasomal degradation. Biochim Biophys Acta. 2014 Jan; 1843(1):216-21. Erales J, Coffino P. PMID: 23684952.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    4. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. PMID: 23644457.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    5. Slippery substrates impair function of a bacterial protease ATPase by unbalancing translocation versus exit. J Biol Chem. 2013 May 10; 288(19):13243-57. Too PH, Erales J, Simen JD, Marjanovic A, Coffino P. PMID: 23530043.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    6. Ubiquitin proteasome system in stress and disease. Biochem Res Int. 2012; 2012:454796. Karpov D, Glickman MH, Bar-Nun S, Coffino P. PMID: 23227337.
      View in: PubMed   Mentions:
    7. Functional asymmetries of proteasome translocase pore. J Biol Chem. 2012 May 25; 287(22):18535-43. Erales J, Hoyt MA, Troll F, Coffino P. PMID: 22493437.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    8. Dependence of proteasome processing rate on substrate unfolding. J Biol Chem. 2011 May 20; 286(20):17495-502. Henderson A, Erales J, Hoyt MA, Coffino P. PMID: 21454622.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    9. Ordering an engagement ring. Mol Cell. 2010 May 14; 38(3):319-20. Hoyt MA, Coffino P. PMID: 20471937.
      View in: PubMed   Mentions:    Fields:    
    10. Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase. Biochem J. 2008 Mar 01; 410(2):401-7. Takeuchi J, Chen H, Hoyt MA, Coffino P. PMID: 17979831.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    11. A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate. Yeast. 2008 Mar; 25(3):199-217. Hoyt MA, McDonough S, Pimpl SA, Scheel H, Hofmann K, Coffino P. PMID: 18260085.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Proteasome substrate degradation requires association plus extended peptide. EMBO J. 2007 Jan 10; 26(1):123-31. Takeuchi J, Chen H, Coffino P. PMID: 17170706.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    13. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 2007 Jan; 18(1):153-65. Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH. PMID: 17065559.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    14. Glycine-alanine repeats impair proper substrate unfolding by the proteasome. EMBO J. 2006 Apr 19; 25(8):1720-9. Hoyt MA, Zich J, Takeuchi J, Zhang M, Govaerts C, Coffino P. PMID: 16601692.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    15. Probing the ubiquitin/proteasome system with ornithine decarboxylase, a ubiquitin-independent substrate. Methods Enzymol. 2005; 398:399-413. Hoyt MA, Zhang M, Coffino P. PMID: 16275346.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. Varshavsky's contributions. Science. 2004 Nov 19; 306(5700):1290-2. Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, Jentsch S, Johnson E, Kwon YT, Pagano M, Pickart C, Rechsteiner M, Scheffner M, Sommer T, Tansey W, Tyers M, Vierstra R, Weissman A, Wilkinson KD, Wolf D. PMID: 15550643.
      View in: PubMed   Mentions:    Fields:    
    17. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science. 2004 Oct 01; 306(5693):117-20. Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. PMID: 15459393.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    18. Development of a method for screening short-lived proteins using green fluorescent protein. Genome Biol. 2004; 5(10):R81. Jiang X, Coffino P, Li X. PMID: 15461799.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Proteasomes begin ornithine decarboxylase digestion at the C terminus. J Biol Chem. 2004 May 14; 279(20):20959-65. Zhang M, MacDonald AI, Hoyt MA, Coffino P. PMID: 15016805.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome substrate processing. J Biol Chem. 2004 Mar 05; 279(10):8635-41. Zhang M, Coffino P. PMID: 14688254.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    21. Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J. 2003 Apr 01; 22(7):1488-96. Zhang M, Pickart CM, Coffino P. PMID: 12660156.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    22. Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. Int J Biochem Cell Biol. 2003 Apr; 35(4):496-521. Auvinen M, Järvinen K, Hotti A, Okkeri J, Laitinen J, Jänne OA, Coffino P, Bergman M, Andersson LC, Alitalo K, Hölttä E. PMID: 12565711.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    23. Ubiquitin-independent mechanisms of mouse ornithine decarboxylase degradation are conserved between mammalian and fungal cells. J Biol Chem. 2003 Apr 04; 278(14):12135-43. Hoyt MA, Zhang M, Coffino P. PMID: 12562772.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002 Nov 29; 277(48):45957-61. Chen H, MacDonald A, Coffino P. PMID: 12359729.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    25. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. J Biol Chem. 2002 May 03; 277(18):15486-98. Li Z, Zou CB, Yao Y, Hoyt MA, McDonough S, Mackey ZB, Coffino P, Wang CC. PMID: 11854272.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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