Philip Coffino, MD, PhD

Title(s)Professor Emeritus, Microbiology and Immunology
SchoolSchool of Medicine
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    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structure of functionally important dynamic states of the proteasome
    NIH/NIGMS R01GM107124Sep 15, 2014 - Aug 31, 2018
    Role: Principal Investigator
    A novel biochemical nanomotor
    NIH/NIBIB R21EB009236May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Energy production and utilization in the proteasome
    NIH/NIGMS R01GM074760Aug 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    NIH/NIGMS R41GM062115Mar 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    NIH/NCI R13CA082148Aug 18, 1999 - Jul 31, 2000
    Role: Principal Investigator
    NIH/FIC F06TW002274Dec 3, 1998
    Role: Principal Investigator
    Proteasome substrate processing
    NIH/NIGMS R01GM045335Jan 1, 1991 - Jan 31, 2015
    Role: Principal Investigator
    NIH/NCI R01CA047721May 1, 1988 - Apr 30, 1992
    Role: Principal Investigator
    NIH/NIA R13AG006771Jul 1, 1986 - Jul 31, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    NIH/NCI R01CA029048Feb 1, 1982 - Feb 29, 1996
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coffino P, Too PH, Erales J. Slippery substrates impair ATP-dependent protease function by slowing unfolding. J Biol Chem. 2014 Feb 07; 289(6):3826. PMID: 24510918; PMCID: PMC3916579.
    2. Erales J, Coffino P. Ubiquitin-independent proteasomal degradation. Biochim Biophys Acta. 2014 Jan; 1843(1):216-21. PMID: 23684952; PMCID: PMC3770795.
    3. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. PMID: 23644457; PMCID: PMC3687086.
    4. Too PH, Erales J, Simen JD, Marjanovic A, Coffino P. Slippery substrates impair function of a bacterial protease ATPase by unbalancing translocation versus exit. J Biol Chem. 2013 May 10; 288(19):13243-57. PMID: 23530043; PMCID: PMC3650364.
    5. Karpov D, Glickman MH, Bar-Nun S, Coffino P. Ubiquitin proteasome system in stress and disease. Biochem Res Int. 2012; 2012:454796. PMID: 23227337; PMCID: PMC3513720.
    6. Erales J, Hoyt MA, Troll F, Coffino P. Functional asymmetries of proteasome translocase pore. J Biol Chem. 2012 May 25; 287(22):18535-43. PMID: 22493437; PMCID: PMC3365715.
    7. Henderson A, Erales J, Hoyt MA, Coffino P. Dependence of proteasome processing rate on substrate unfolding. J Biol Chem. 2011 May 20; 286(20):17495-502. PMID: 21454622; PMCID: PMC3093823.
    8. Hoyt MA, Coffino P. Ordering an engagement ring. Mol Cell. 2010 May 14; 38(3):319-20. PMID: 20471937.
      View in: PubMed
    9. Takeuchi J, Chen H, Hoyt MA, Coffino P. Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase. Biochem J. 2008 Mar 01; 410(2):401-7. PMID: 17979831.
      View in: PubMed
    10. Hoyt MA, McDonough S, Pimpl SA, Scheel H, Hofmann K, Coffino P. A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate. Yeast. 2008 Mar; 25(3):199-217. PMID: 18260085.
      View in: PubMed
    11. Takeuchi J, Chen H, Coffino P. Proteasome substrate degradation requires association plus extended peptide. EMBO J. 2007 Jan 10; 26(1):123-31. PMID: 17170706; PMCID: PMC1782366.
    12. Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 2007 Jan; 18(1):153-65. PMID: 17065559.
      View in: PubMed
    13. Hoyt MA, Zich J, Takeuchi J, Zhang M, Govaerts C, Coffino P. Glycine-alanine repeats impair proper substrate unfolding by the proteasome. EMBO J. 2006 Apr 19; 25(8):1720-9. PMID: 16601692; PMCID: PMC1440830.
    14. Hoyt MA, Zhang M, Coffino P. Probing the ubiquitin/proteasome system with ornithine decarboxylase, a ubiquitin-independent substrate. Methods Enzymol. 2005; 398:399-413. PMID: 16275346.
      View in: PubMed
    15. Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, Jentsch S, Johnson E, Kwon YT, Pagano M, Pickart C, Rechsteiner M, Scheffner M, Sommer T, Tansey W, Tyers M, Vierstra R, Weissman A, Wilkinson KD, Wolf D. Varshavsky's contributions. Science. 2004 Nov 19; 306(5700):1290-2. PMID: 15550643.
      View in: PubMed
    16. Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science. 2004 Oct 01; 306(5693):117-20. PMID: 15459393.
      View in: PubMed
    17. Jiang X, Coffino P, Li X. Development of a method for screening short-lived proteins using green fluorescent protein. Genome Biol. 2004; 5(10):R81. PMID: 15461799; PMCID: PMC545601.
    18. Zhang M, MacDonald AI, Hoyt MA, Coffino P. Proteasomes begin ornithine decarboxylase digestion at the C terminus. J Biol Chem. 2004 May 14; 279(20):20959-65. PMID: 15016805.
      View in: PubMed
    19. Zhang M, Coffino P. Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome substrate processing. J Biol Chem. 2004 Mar 05; 279(10):8635-41. PMID: 14688254.
      View in: PubMed
    20. Zhang M, Pickart CM, Coffino P. Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J. 2003 Apr 01; 22(7):1488-96. PMID: 12660156; PMCID: PMC152902.
    21. Auvinen M, Järvinen K, Hotti A, Okkeri J, Laitinen J, Jänne OA, Coffino P, Bergman M, Andersson LC, Alitalo K, Hölttä E. Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. Int J Biochem Cell Biol. 2003 Apr; 35(4):496-521. PMID: 12565711.
      View in: PubMed
    22. Hoyt MA, Zhang M, Coffino P. Ubiquitin-independent mechanisms of mouse ornithine decarboxylase degradation are conserved between mammalian and fungal cells. J Biol Chem. 2003 Apr 04; 278(14):12135-43. PMID: 12562772.
      View in: PubMed
    23. Chen H, MacDonald A, Coffino P. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002 Nov 29; 277(48):45957-61. PMID: 12359729.
      View in: PubMed
    24. Li Z, Zou CB, Yao Y, Hoyt MA, McDonough S, Mackey ZB, Coffino P, Wang CC. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. J Biol Chem. 2002 May 03; 277(18):15486-98. PMID: 11854272.
      View in: PubMed
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