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Philip Coffino, MD, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentMicrobiology and Immunology
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
Phone415-476-1783
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structure of functionally important dynamic states of the proteasome
    NIH/NIGMS R01GM107124Sep 15, 2014 - Aug 31, 2018
    Role: Principal Investigator
    A novel biochemical nanomotor
    NIH/NIBIB R21EB009236May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Energy production and utilization in the proteasome
    NIH/NIGMS R01GM074760Aug 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    INDUCED SELECTIVE DEGRADATION OF CELLULAR PROTEINS
    NIH/NIGMS R41GM062115Mar 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    GORDON CONFERENCE ON POLYAMINES
    NIH/NCI R13CA082148Aug 18, 1999 - Jul 31, 2000
    Role: Principal Investigator
    REGULATION OF YEAST ORNITHINE DECARBOXYLASE DEGRADATION
    NIH/FIC F06TW002274Dec 3, 1998
    Role: Principal Investigator
    Proteasome substrate processing
    NIH/NIGMS R01GM045335Jan 1, 1991 - Jan 31, 2015
    Role: Principal Investigator
    FUNCTIONAL ANATOMY OF ORNITHINE DECARBOXYLASE
    NIH/NCI R01CA047721May 1, 1988 - Apr 30, 1992
    Role: Principal Investigator
    FASEB SUMMER RESEARCH CONFERENCE--SOMATIC CELL GENETICS
    NIH/NIA R13AG006771Jul 1, 1986 - Jul 31, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    MECHANISMS OF ORNITHINE DECARBOXYLASE REGULATION
    NIH/NCI R01CA029048Feb 1, 1982 - Feb 29, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coffino P, Too PH, Erales J. Slippery substrates impair ATP-dependent protease function by slowing unfolding. J Biol Chem. 2014 Feb 7; 289(6):3826. PMID: 24510918; PMCID: PMC3916579.
    2. Erales J, Coffino P. Ubiquitin-independent proteasomal degradation. Biochim Biophys Acta. 2014 Jan; 1843(1):216-21. PMID: 23684952; PMCID: PMC3770795.
    3. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. PMID: 23644457; PMCID: PMC3687086.
    4. Too PH, Erales J, Simen JD, Marjanovic A, Coffino P. Slippery substrates impair function of a bacterial protease ATPase by unbalancing translocation versus exit. J Biol Chem. 2013 May 10; 288(19):13243-57. PMID: 23530043; PMCID: PMC3650364.
    5. Karpov D, Glickman MH, Bar-Nun S, Coffino P. Ubiquitin proteasome system in stress and disease. Biochem Res Int. 2012; 2012:454796. PMID: 23227337; PMCID: PMC3513720.
    6. Erales J, Hoyt MA, Troll F, Coffino P. Functional asymmetries of proteasome translocase pore. J Biol Chem. 2012 May 25; 287(22):18535-43. PMID: 22493437; PMCID: PMC3365715.
    7. Henderson A, Erales J, Hoyt MA, Coffino P. Dependence of proteasome processing rate on substrate unfolding. J Biol Chem. 2011 May 20; 286(20):17495-502. PMID: 21454622; PMCID: PMC3093823.
    8. Hoyt MA, Coffino P. Ordering an engagement ring. Mol Cell. 2010 May 14; 38(3):319-20. PMID: 20471937.
      View in: PubMed
    9. Hoyt MA, McDonough S, Pimpl SA, Scheel H, Hofmann K, Coffino P. A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate. Yeast. 2008 Mar; 25(3):199-217. PMID: 18260085.
      View in: PubMed
    10. Takeuchi J, Chen H, Hoyt MA, Coffino P. Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase. Biochem J. 2008 Mar 1; 410(2):401-7. PMID: 17979831.
      View in: PubMed
    11. Takeuchi J, Chen H, Coffino P. Proteasome substrate degradation requires association plus extended peptide. EMBO J. 2007 Jan 10; 26(1):123-31. PMID: 17170706; PMCID: PMC1782366.
    12. Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 2007 Jan; 18(1):153-65. PMID: 17065559; PMCID: PMC1751312.
    13. Hoyt MA, Zich J, Takeuchi J, Zhang M, Govaerts C, Coffino P. Glycine-alanine repeats impair proper substrate unfolding by the proteasome. EMBO J. 2006 Apr 19; 25(8):1720-9. PMID: 16601692; PMCID: PMC1440830.
    14. Hoyt MA, Zhang M, Coffino P. Probing the ubiquitin/proteasome system with ornithine decarboxylase, a ubiquitin-independent substrate. Methods Enzymol. 2005; 398:399-413. PMID: 16275346.
      View in: PubMed
    15. Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, Jentsch S, Johnson E, Kwon YT, Pagano M, Pickart C, Rechsteiner M, Scheffner M, Sommer T, Tansey W, Tyers M, Vierstra R, Weissman A, Wilkinson KD, Wolf D. Varshavsky's contributions. Science. 2004 Nov 19; 306(5700):1290-2. PMID: 15550643.
      View in: PubMed
    16. Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science. 2004 Oct 1; 306(5693):117-20. PMID: 15459393.
      View in: PubMed
    17. Jiang X, Coffino P, Li X. Development of a method for screening short-lived proteins using green fluorescent protein. Genome Biol. 2004; 5(10):R81. PMID: 15461799; PMCID: PMC545601.
    18. Hoyt MA, Coffino P. Ubiquitin-free routes into the proteasome. Cell Mol Life Sci. 2004 Jul; 61(13):1596-600. PMID: 15224184.
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    19. Zhang M, MacDonald AI, Hoyt MA, Coffino P. Proteasomes begin ornithine decarboxylase digestion at the C terminus. J Biol Chem. 2004 May 14; 279(20):20959-65. PMID: 15016805.
      View in: PubMed
    20. Zhang M, Coffino P. Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome substrate processing. J Biol Chem. 2004 Mar 5; 279(10):8635-41. PMID: 14688254.
      View in: PubMed
    21. Zhang M, Pickart CM, Coffino P. Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J. 2003 Apr 1; 22(7):1488-96. PMID: 12660156; PMCID: PMC152902.
    22. Auvinen M, Järvinen K, Hotti A, Okkeri J, Laitinen J, Jänne OA, Coffino P, Bergman M, Andersson LC, Alitalo K, Hölttä E. Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. Int J Biochem Cell Biol. 2003 Apr; 35(4):496-521. PMID: 12565711.
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    23. Hoyt MA, Zhang M, Coffino P. Ubiquitin-independent mechanisms of mouse ornithine decarboxylase degradation are conserved between mammalian and fungal cells. J Biol Chem. 2003 Apr 4; 278(14):12135-43. PMID: 12562772.
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    24. Chen H, MacDonald A, Coffino P. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002 Nov 29; 277(48):45957-61. PMID: 12359729.
      View in: PubMed
    25. Li Z, Zou CB, Yao Y, Hoyt MA, McDonough S, Mackey ZB, Coffino P, Wang CC. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. J Biol Chem. 2002 May 3; 277(18):15486-98. PMID: 11854272.
      View in: PubMed
    26. Coffino P. Regulation of cellular polyamines by antizyme. Nat Rev Mol Cell Biol. 2001 Mar; 2(3):188-94. PMID: 11265248.
      View in: PubMed
    27. Coffino P. Antizyme, a mediator of ubiquitin-independent proteasomal degradation. Biochimie. 2001 Mar-Apr; 83(3-4):319-23. PMID: 11295492.
      View in: PubMed
    28. Zhu C, Karplus K, Grate L, Coffino P. A homolog of mammalian antizyme is present in fission yeast Schizosaccharomyces pombe but not detected in budding yeast Saccharomyces cerevisiae. Bioinformatics. 2000 May; 16(5):478-81. PMID: 10871270.
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    29. Coffino P. Polyamines in spermiogenesis: not now, darling. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4421-3. PMID: 10781034; PMCID: PMC34313.
    30. Yao Y, Toth CR, Huang L, Wong ML, Dias P, Burlingame AL, Coffino P, Wang CC. alpha5 subunit in Trypanosoma brucei proteasome can self-assemble to form a cylinder of four stacked heptamer rings. Biochem J. 1999 Dec 1; 344 Pt 2:349-58. PMID: 10567215; PMCID: PMC1220650.
    31. Zhu C, Lang DW, Coffino P. Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport. J Biol Chem. 1999 Sep 10; 274(37):26425-30. PMID: 10473601.
      View in: PubMed
    32. Toth C, Coffino P. Regulated degradation of yeast ornithine decarboxylase. J Biol Chem. 1999 Sep 3; 274(36):25921-6. PMID: 10464336.
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    33. Kern AD, Oliveira MA, Coffino P, Hackert ML. Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases. Structure. 1999 May; 7(5):567-81. PMID: 10378276.
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    34. MacRae M, Kramer DL, Coffino P. Developmental effect of polyamine depletion in Caenorhabditis elegans. Biochem J. 1998 Jul 15; 333 ( Pt 2):309-15. PMID: 9657970; PMCID: PMC1219587.
    35. Li X, Coffino P. High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation. J Virol. 1996 Jul; 70(7):4509-16. PMID: 8676476; PMCID: PMC190386.
    36. Li X, Stebbins B, Hoffman L, Pratt G, Rechsteiner M, Coffino P. The N terminus of antizyme promotes degradation of heterologous proteins. J Biol Chem. 1996 Feb 23; 271(8):4441-6. PMID: 8626796.
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    37. Li X, Coffino P. Identification of a region of p53 that confers lability. J Biol Chem. 1996 Feb 23; 271(8):4447-51. PMID: 8626797.
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    38. Kern A, Oliveira MA, Chang NL, Ernst SR, Carroll DW, Momany C, Minard K, Coffino P, Hackert ML. Crystallization of a mammalian ornithine decarboxylase. Proteins. 1996 Feb; 24(2):266-8. PMID: 8820494.
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    39. Macrae M, Plasterk RH, Coffino P. The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis. Genetics. 1995 Jun; 140(2):517-25. PMID: 7498733; PMCID: PMC1206631.
    40. Hua SB, Li X, Coffino P, Wang CC. Rat antizyme inhibits the activity but does not promote the degradation of mouse ornithine decarboxylase in Trypanosoma brucei. J Biol Chem. 1995 Apr 28; 270(17):10264-71. PMID: 7730330.
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    41. Elias S, Bercovich B, Kahana C, Coffino P, Fischer M, Hilt W, Wolf DH, Ciechanover A. Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease. Eur J Biochem. 1995 Apr 1; 229(1):276-83. PMID: 7744041.
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    42. Li X, Coffino P. Distinct domains of antizyme required for binding and proteolysis of ornithine decarboxylase. Mol Cell Biol. 1994 Jan; 14(1):87-92. PMID: 8264655; PMCID: PMC358359.
    43. Tsirka SE, Turck CW, Coffino P. Multiple active conformers of mouse ornithine decarboxylase. Biochem J. 1993 Jul 1; 293 ( Pt 1):289-95. PMID: 8328969; PMCID: PMC1134353.
    44. Li X, Coffino P. Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein. Mol Cell Biol. 1993 Apr; 13(4):2377-83. PMID: 8455617; PMCID: PMC359558.
    45. Tsirka S, Coffino P. Dominant negative mutants of ornithine decarboxylase. J Biol Chem. 1992 Nov 15; 267(32):23057-62. PMID: 1429654.
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    46. Ghoda L, Basu HS, Porter CW, Marton LJ, Coffino P. Role of ornithine decarboxylase suppression and polyamine depletion in the antiproliferative activity of polyamine analogs. Mol Pharmacol. 1992 Aug; 42(2):302-6. PMID: 1513327.
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    47. Li X, Coffino P. Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme. Mol Cell Biol. 1992 Aug; 12(8):3556-62. PMID: 1630460; PMCID: PMC364621.
    48. Davis RH, Morris DR, Coffino P. Sequestered end products and enzyme regulation: the case of ornithine decarboxylase. Microbiol Rev. 1992 Jun; 56(2):280-90. PMID: 1620066; PMCID: PMC372868.
    49. Ghoda L, Sidney D, Macrae M, Coffino P. Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation. Mol Cell Biol. 1992 May; 12(5):2178-85. PMID: 1569947; PMCID: PMC364389.
    50. Osborne HB, Duval C, Ghoda L, Omilli F, Bassez T, Coffino P. Expression and post-transcriptional regulation of ornithine decarboxylase during early Xenopus development. Eur J Biochem. 1991 Dec 5; 202(2):575-81. PMID: 1761057.
      View in: PubMed
    51. Coffino P, Poznanski A. Killer polyamines? J Cell Biochem. 1991 Jan; 45(1):54-8. PMID: 2005185.
      View in: PubMed
    52. Ghoda L, Wang CC, Coffino P. Ornithine decarboxylase of African trypanosomes. Biochem Soc Trans. 1990 Oct; 18(5):739-40. PMID: 2083662.
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    53. Ghoda L, Phillips MA, Bass KE, Wang CC, Coffino P. Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation. J Biol Chem. 1990 Jul 15; 265(20):11823-6. PMID: 2365702.
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    54. van Daalen Wetters T, Brabant M, Coffino P. Regulation of mouse ornithine decarboxylase activity by cell growth, serum and tetradecanoyl phorbol acetate is governed primarily by sequences within the coding region of the gene. Nucleic Acids Res. 1989 Dec 11; 17(23):9843-60. PMID: 2602143; PMCID: PMC335218.
    55. van Daalen Wetters T, Macrae M, Brabant M, Sittler A, Coffino P. Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational. Mol Cell Biol. 1989 Dec; 9(12):5484-90. PMID: 2511435; PMCID: PMC363718.
    56. Villani V, Coffino P, D'Eustachio P. Linkage genetics of mouse ornithine decarboxylase (Odc). Genomics. 1989 Oct; 5(3):636-8. PMID: 2575591.
      View in: PubMed
    57. Ghoda L, van Daalen Wetters T, Macrae M, Ascherman D, Coffino P. Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation. Science. 1989 Mar 17; 243(4897):1493-5. PMID: 2928784.
      View in: PubMed
    58. Phillips MA, Coffino P, Wang CC. Trypanosoma brucei ornithine decarboxylase: enzyme purification, characterization, and expression in Escherichia coli. J Biol Chem. 1988 Dec 5; 263(34):17933-41. PMID: 3056933.
      View in: PubMed
    59. Coffino P. Probable cloning artefacts previously interpreted as unusual leader sequences of rodent ornithine decarboxylase mRNAs--a cautionary tale. Gene. 1988 Sep 30; 69(2):365-8. PMID: 3234772.
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    60. Brabant M, McConlogue L, van Daalen Wetters T, Coffino P. Mouse ornithine decarboxylase gene: cloning, structure, and expression. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2200-4. PMID: 3353375; PMCID: PMC279957.
    61. Coffino P, Chen EL. Nucleotide sequence of the mouse ornithine decarboxylase gene. Nucleic Acids Res. 1988 Mar 25; 16(6):2731-2. PMID: 3362685; PMCID: PMC336413.
    62. Cox DR, Trouillot T, Ashley PL, Brabant M, Coffino P. A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2. Cytogenet Cell Genet. 1988; 48(2):92-4. PMID: 3197454.
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    63. Phillips MA, Coffino P, Wang CC. Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition. J Biol Chem. 1987 Jun 25; 262(18):8721-7. PMID: 3036823.
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    64. van Daalen Wetters T, Coffino P. Cultured S49 mouse T lymphoma cells. Methods Enzymol. 1987; 151:9-19. PMID: 3501530.
      View in: PubMed
    65. Macrae M, Coffino P. Complementation of a polyamine-deficient Escherichia coli mutant by expression of mouse ornithine decarboxylase. Mol Cell Biol. 1987 Jan; 7(1):564-7. PMID: 3550425; PMCID: PMC365106.
    66. McConlogue L, Dana SL, Coffino P. Multiple mechanisms are responsible for altered expression of ornithine decarboxylase in overproducing variant cells. Mol Cell Biol. 1986 Aug; 6(8):2865-71. PMID: 3023951; PMCID: PMC367854.
    67. Feinstein SC, Dana SL, McConlogue L, Shooter EM, Coffino P. Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5761-5. PMID: 3862093; PMCID: PMC390632.
    68. Gupta M, Coffino P. Mouse ornithine decarboxylase. Complete amino acid sequence deduced from cDNA. J Biol Chem. 1985 Mar 10; 260(5):2941-4. PMID: 2982844.
      View in: PubMed
    69. Stimac E, Groppi VE, Coffino P. Inhibition of protein synthesis stabilizes histone mRNA. Mol Cell Biol. 1984 Oct; 4(10):2082-90. PMID: 6209555; PMCID: PMC369025.
    70. McConlogue L, Gupta M, Wu L, Coffino P. Molecular cloning and expression of the mouse ornithine decarboxylase gene. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):540-4. PMID: 6582509; PMCID: PMC344714.
    71. van Daalen Wetters T, Murtaugh MP, Coffino P. Revertants of a trans-dominant S49 mouse lymphoma mutant that affects expression of cAMP-dependent protein kinase. Cell. 1983 Nov; 35(1):311-20. PMID: 6627398.
      View in: PubMed
    72. McConlogue L, Coffino P. A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase. J Biol Chem. 1983 Oct 25; 258(20):12083-6. PMID: 6415048.
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    73. Stimac E, Groppi VE, Coffino P. Increased histone mRNA levels during inhibition of protein synthesis. Biochem Biophys Res Commun. 1983 Jul 18; 114(1):131-7. PMID: 6882419.
      View in: PubMed
    74. McConlogue L, Coffino P. Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover. J Biol Chem. 1983 Jul 10; 258(13):8384-8. PMID: 6408089.
      View in: PubMed
    75. McConlogue LC, Marton LJ, Coffino P. Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells. J Cell Biol. 1983 Mar; 96(3):762-7. PMID: 6300139; PMCID: PMC2112398.
    76. van Daalen Wetters T, Coffino P. Reversion of an S49 cell cyclic AMP-dependent protein kinase structural gene mutant occurs primarily by functional elimination of mutant gene expression. Mol Cell Biol. 1983 Feb; 3(2):250-6. PMID: 6300660; PMCID: PMC368529.
    77. van Daalen Wetters T, Coffino P. Revertants of an S49 cell mutant that expresses altered cyclic AMP-dependent protein kinase. Mol Cell Biol. 1982 Oct; 2(10):1229-37. PMID: 6294499; PMCID: PMC369922.
    78. Caras IW, MacInnes MA, Persing DH, Coffino P, Martin DW. Mechanism of 2-aminopurine mutagenesis in mouse T-lymphosarcoma cells. Mol Cell Biol. 1982 Sep; 2(9):1096-103. PMID: 6983647; PMCID: PMC369902.
    79. MacInnes MA, Friedrich U, van Daalen Wetters T, Coffino P. Quantitative forward-mutation specificity of mono-functional alkylating agents, ICR-191, and aflatoxin B1 in mouse lymphoma cells. Mutat Res. 1982 Aug; 95(2-3):297-311. PMID: 6289092.
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    80. Coffino P. Hormonal regulation of cloned genes. Nature. 1981 Aug 6; 292(5823):492-3. PMID: 7254346.
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    81. Coffino P, Groppi VE. Growth regulation of S49 lymphoma cells: analysis of cAMP responsiveness and polyamine metabolism. Adv Cyclic Nucleotide Res. 1981; 14:399-410. PMID: 6269391.
      View in: PubMed
    82. Groppi VE, Coffino P. G1 and S phase mammalian cells synthesize histones at equivalent rates. Cell. 1980 Aug; 21(1):195-204. PMID: 7407911.
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    83. Kaiser N, Bourne HR, Insel PA, Coffino P. Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent. J Cell Physiol. 1979 Dec; 101(3):369-74. PMID: 231036.
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    84. Steinberg RA, Coffino P. Two-dimensional gel analysis of cyclic AMP effects in cultured S49 mouse lymphoma cells: protein modifications, inductions and repressions. Cell. 1979 Nov; 18(3):719-33. PMID: 229961.
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    85. Johnson GL, Bourne HR, Gleason MK, Coffino P, Insel PA, Melmon KL. Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase. Mol Pharmacol. 1979 Jan; 15(1):16-27. PMID: 34089.
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    86. Gray JW, Coffino P. Cell cycle analysis by flow cytometry. Methods Enzymol. 1979; 58:233-48. PMID: 423764.
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    87. Steinberg RA, van Daalen Wetters T, Coffino P. Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase. Cell. 1978 Dec; 15(4):1351-61. PMID: 215323.
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    88. Coffino P, Gray JW. Regulation of S49 lymphoma cell growth by cyclic adenosine 3':5'-monophosphate. Cancer Res. 1978 Nov; 38(11 Pt 2):4285-8. PMID: 212191.
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    89. Coffino P. Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase. Natl Cancer Inst Monogr. 1978 May; (48):377-80. PMID: 219362.
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    90. Naya-Vigne J, Johnson GL, Bourne HR, Coffino P. Complementation analysis of hormone-sensitive adenylate cyclase. Nature. 1978 Apr 20; 272(5655):720-2. PMID: 205796.
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    91. Coffino P, Bourne HR, Insel PA, Melmon KL, Johnson G, Vigne J. Studies of cyclic AMP action using mutant tissue culture cells. In Vitro. 1978 Jan; 14(1):140-5. PMID: 23989.
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    92. Lemaire I, Coffino P. Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP. J Cell Physiol. 1977 Sep; 92(3):437-45. PMID: 198416.
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    93. Gehring U, Coffino P. Independent mechanisms of cyclic AMP and glucocorticoid action. Nature. 1977 Jul 14; 268(5616):167-9. PMID: 201848.
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    94. Friedrich U, Coffino P. Hypoxanthine-guanine phosphoribosyl transferase with altered substrate affinity in mutant mouse lymphoma cells. Biochim Biophys Acta. 1977 Jul 8; 483(1):70-8. PMID: 560213.
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    95. Lemaire I, Coffino P. Cyclic AMP-induced cytolysis in S49 cells: selection of an unresponsive "deathless" mutant. Cell. 1977 May; 11(1):149-55. PMID: 194702.
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    96. Hochman J, Bourne HR, Coffino P, Insel PA, Krasny L, Melmon KL. Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):1167-71. PMID: 191831; PMCID: PMC430635.
    97. Steinberg RA, O'Farrell PH, Friedrich U, Coffino P. Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells. Cell. 1977 Mar; 10(3):381-91. PMID: 191196.
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    98. Friedrich U, Coffino P. Mutagenesis in S49 mouse lymphoma cells: induction of resistance to ouabain, 6-thioguanine, and dibutyryl cyclic AMP. Proc Natl Acad Sci U S A. 1977 Feb; 74(2):679-83. PMID: 191823; PMCID: PMC392356.
    99. Shear M, Insel PA, Melmon KL, Coffino P. Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells. J Biol Chem. 1976 Dec 10; 251(23):7572-6. PMID: 187593.
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    100. Insel PA, Maguire ME, Gilman AG, Bourne HR, Coffino P, Melmon KL. Beta adrenergic receptors and adenylate cyclase: products of separate genes? Mol Pharmacol. 1976 Nov; 12(6):1062-9. PMID: 187924.
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    101. Coffino P, Bourne HR, Friedrich U, Hochman J, Insel PA, Lemaire I, Melmon KL, Tomkins GM. Molecular mechanisms of cyclic AMP action: a genetic approach. Recent Prog Horm Res. 1976; 32:669-84. PMID: 183250.
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