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Lisa McConlogue, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-476-4836
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    Collapse Overview
    The McConlogue laboratory focuses on both understanding the mechanisms involved in neurodegeneration driven by misfolding-prone proteins and in developing therapeutic approaches to treat neurological diseases such as Alzheimer’s and Parkinson’s diseases (AD and PD). We are particularly interested in understanding the pathogenic role and functional perturbation of intrinsically disordered proteins (IDP) that, due to their unique structural characteristics and key functional roles, lead to diseases of amyloid-type misfolding including cancer and neurodegenerative diseases.
    Our current focus is on understanding and blocking the pathogenic processes of α-Synuclein (α-Syn), an IDP that plays a central role in PD and also contributes to AD. We are developing small molecules that act as chaperones restoring the native structure and function of α-Syn under disease conditions to both probe the pathogenic mechanisms of α-Syn misfolding and malfunction, and to develop therapies to treat PD, AD and related diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Small-Molecule Pharmacological Chaperones to Prevent Synuclein Transmission
    NIH/NINDS R21NS092897Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of a-Synuclein Protect Against Diverse a-Synuclein Mediated Dysfunctions. Sci Rep. 2019 11 18; 9(1):16947. Tóth G, Neumann T, Berthet A, Masliah E, Spencer B, Tao J, Jobling MF, Gardai SJ, Bertoncini CW, Cremades N, Bova M, Ballaron S, Chen XH, Mao W, Nguyen P, Tabios MC, Tambe MA, Rochet JC, Junker HD, Schwizer D, Sekul R, Ott I, Anderson JP, Szoke B, Hoffman W, Christodoulou J, Yednock T, Agard DA, Schenk D, McConlogue L. PMID: 31740740.
      View in: PubMed   Mentions:    Fields:    
    2. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Curr Alzheimer Res. 2015; 12(9):814-28. Pickhardt M, Neumann T, Schwizer D, Callaway K, Vendruscolo M, Schenk D, St George-Hyslop P, Mandelkow EM, Dobson CM, McConlogue L, Mandelkow E, Tóth G. PMID: 26510979.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    3. Targeting the intrinsically disordered structural ensemble of a-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One. 2014; 9(2):e87133. Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L. PMID: 24551051.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    4. Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease. PLoS One. 2013; 8(8):e71634. Gardai SJ, Mao W, Schüle B, Babcock M, Schoebel S, Lorenzana C, Alexander J, Kim S, Glick H, Hilton K, Fitzgerald JK, Buttini M, Chiou SS, McConlogue L, Anderson JP, Schenk DB, Bard F, Langston JW, Yednock T, Johnston JA. PMID: 24058406.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    5. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One. 2011 Apr 29; 6(4):e19338. Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D. PMID: 21559417.
      View in: PubMed   Mentions: 171     Fields:    Translation:AnimalsCells
    6. Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem. 2009 Jan 30; 284(5):2598-602. Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP. PMID: 19004816.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    7. Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice. J Biol Chem. 2007 Sep 07; 282(36):26326-34. McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S. PMID: 17616527.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    8. BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease. Neurobiol Aging. 2008 Jun; 29(6):861-73. Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, Freedman S, Morris RG, Chen KS. PMID: 17331621.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    9. Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells. J Biol Chem. 2003 Aug 22; 278(34):31512-20. Basi G, Frigon N, Barbour R, Doan T, Gordon G, McConlogue L, Sinha S, Zeller M. PMID: 12801932.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    10. Key signaling pathways regulate the biological activities and accumulation of amyloid-beta. Neurobiol Aging. 2001 Nov-Dec; 22(6):967-73. Wyss-Coray T, McConlogue L, Kindy M, Schmidt AM, Du Yan S, Stern DM. PMID: 11755005.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001 Jun 01; 10(12):1317-24. Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. PMID: 11406613.
      View in: PubMed   Mentions: 190     Fields:    Translation:AnimalsCells
    12. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med. 2001 May; 7(5):612-8. Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. PMID: 11329064.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimalsCells
    13. Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide. J Biol Chem. 2001 Jun 08; 276(23):20267-79. Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L. PMID: 11278337.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    14. Alzheimer’s Disease:Advances in Etiology, Pathogenesis and Therapeutics. Functional analysis of β-secretase using mutagenesis and structural homology modeling. 2001; Chapter 74:799-808. . 41 Gwen Tatsuno, John Anderson , Jin Hong, David A. Agard, Nobuyuki Ota, Sukanto Sinha, Guriqbal Basi, Lisa McConlogue . .
    15. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature. 2000 Dec 21-28; 408(6815):975-9. Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG. PMID: 11140684.
      View in: PubMed   Mentions: 195     Fields:    Translation:Animals
    16. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. Am J Pathol. 2000 Dec; 157(6):2003-10. Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. PMID: 11106573.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    17. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000 Jun 01; 20(11):4050-8. Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L. PMID: 10818140.
      View in: PubMed   Mentions: 617     Fields:    Translation:HumansAnimalsCells
    18. Recent advances in the understanding of the processing of APP to beta amyloid peptide. Ann N Y Acad Sci. 2000; 920:206-8. Sinha S, Anderson J, John V, McConlogue L, Basi G, Thorsett E, Schenk D. PMID: 11193151.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999 Dec 02; 402(6761):537-40. Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V. PMID: 10591214.
      View in: PubMed   Mentions: 384     Fields:    Translation:HumansAnimalsCells
    20. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol. 1999 Nov; 155(5):1741-7. Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L. PMID: 10550330.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    21. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3228-33. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L. PMID: 10077666.
      View in: PubMed   Mentions: 344     Fields:    Translation:HumansAnimals
    22. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus. Biochim Biophys Acta. 1998 Jul 01; 1407(1):69-78. Tan Y, Hong J, Doan T, McConlogue L, Maltese WA. PMID: 9639678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature. 1997 Oct 09; 389(6651):603-6. Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L. PMID: 9335500.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    24. Individual isoforms of the amyloid beta precursor protein demonstrate differential adhesive potentials to constituents of the extracellular matrix. J Neurosci Res. 1997 Jul 15; 49(2):154-60. Gillian AM, McFarlane I, Lucy FM, Overly C, McConlogue L, Breen KC. PMID: 9272638.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    25. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1550-5. Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L. PMID: 9037091.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    26. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J Biol Chem. 1996 Dec 06; 271(49):31407-11. Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. PMID: 8940150.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    27. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. J Biol Chem. 1996 Jan 19; 271(3):1343-8. McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA. PMID: 8576122.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    28. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem. 1995 Nov 24; 270(47):28257-67. Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. PMID: 7499323.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    29. The potential utility of transgenic mice harboring beta-amyloid precursor protein. Neurobiol Aging. 1995 Jul-Aug; 16(4):711-3; discussion 715-8. Schenk D, Games KD, McConlogue L. PMID: 8544925.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. The Ras-related GTP-binding protein, Rab1B, regulates early steps in exocytic transport and processing of beta-amyloid precursor protein. J Biol Chem. 1995 May 05; 270(18):10982-9. Dugan JM, deWit C, McConlogue L, Maltese WA. PMID: 7738040.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    31. Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases. J Biol Chem. 1995 Feb 10; 270(6):2419-22. Knops J, Suomensaari S, Lee M, McConlogue L, Seubert P, Sinha S. PMID: 7852298.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    32. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995 Feb 09; 373(6514):523-7. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F. PMID: 7845465.
      View in: PubMed   Mentions: 405     Fields:    Translation:HumansAnimalsCells
    33. Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells. Cell Motil Cytoskeleton. 1994; 28(3):195-8. Kosik KS, McConlogue L. PMID: 7954847.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    34. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 1992 Dec 17; 360(6405):672-4. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. PMID: 1465129.
      View in: PubMed   Mentions: 356     Fields:    Translation:HumansCells
    35. The beta-amyloid precursor protein is not processed by the regulated secretory pathway. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):513-9. Overly CC, Fritz LC, Lieberburg I, McConlogue L. PMID: 1661581.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. Overexpression of tau in a nonneuronal cell induces long cellular processes. J Cell Biol. 1991 Aug; 114(4):725-33. Knops J, Kosik KS, Lee G, Pardee JD, Cohen-Gould L, McConlogue L. PMID: 1678391.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    37. Isolation of baculovirus-derived secreted and full-length beta-amyloid precursor protein. J Biol Chem. 1991 Apr 15; 266(11):7285-90. Knops J, Johnson-Wood K, Schenk DB, Sinha S, Lieberburg I, McConlogue L. PMID: 1901866.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. Structure-independent DNA amplification by PCR using 7-deaza-2'-deoxyguanosine. Nucleic Acids Res. 1988 Oct 25; 16(20):9869. McConlogue L, Brow MA, Innis MA. PMID: 3186456.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    39. Mouse ornithine decarboxylase gene: cloning, structure, and expression. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2200-4. Brabant M, McConlogue L, van Daalen Wetters T, Coffino P. PMID: 3353375.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    40. Amplification and expression of heterologous ornithine decarboxylase in Chinese hamster cells. Mol Cell Biol. 1988 Feb; 8(2):764-9. Chiang TR, McConlogue L. PMID: 3352604.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    41. Multiple mechanisms are responsible for altered expression of ornithine decarboxylase in overproducing variant cells. Mol Cell Biol. 1986 Aug; 6(8):2865-71. McConlogue L, Dana SL, Coffino P. PMID: 3023951.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    42. Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5761-5. Feinstein SC, Dana SL, McConlogue L, Shooter EM, Coffino P. PMID: 3862093.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    43. Molecular cloning and expression of the mouse ornithine decarboxylase gene. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):540-4. McConlogue L, Gupta M, Wu L, Coffino P. PMID: 6582509.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    44. A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase. J Biol Chem. 1983 Oct 25; 258(20):12083-6. McConlogue L, Coffino P. PMID: 6415048.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover. J Biol Chem. 1983 Jul 10; 258(13):8384-8. McConlogue L, Coffino P. PMID: 6408089.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    46. Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells. J Cell Biol. 1983 Mar; 96(3):762-7. McConlogue LC, Marton LJ, Coffino P. PMID: 6300139.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Radioimmune assay of induction and removal of uv lesions in total and staphylococcal nuclease-resistant DNA of mammalian chromatin. Radiat Res. 1982 Feb; 89(2):381-95. McConlogue LC, Ward JF, Lewis HL, Norman A. PMID: 7063620.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    48. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer's Research. 12(9):814-828. Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St. George-Hyslop, Eva M. Mandelkow, Christopher M. Dobson, Lisa McConlogue, Eckhard Mandelkow and Gergely Toth. View Publication.
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