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Jason Gestwicki, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentInstitute for Neurodegenerative Diseases
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Awards and Honors
    University of Michigan2012American Association for the Advancement of Science (AAAS) Fellow
    University of Michigan2009NSF CAREER Award
    University of Michigan2006McKnight Foundation's Brain Disorders Award
    University of Michigan2005Biological Sciences Scholar
    Stanford Univeristy2003Helen Hay Whitney Foundation Fellow
    University of Wisconsin - Madison2001Sigrid Leirmo Award
    University of Wisconsin - Madison1998NIH Biotechnology Training Fellow

    Collapse Overview 
    Collapse Overview
    The Gestwicki Laboratory is interested in molecular chaperones, protein homeostasis and protein misfolding disorders. To approach the big questions in this area, we use a chemical biology strategy that includes the discovery and optimization of new chemical inhibitors. We use these chemical probes to acutely perturb chaperone functions, revealing how these systems normally protect from cancer and neurodegeneration. Many of our chemical probes target allosteric and protein-protein interaction sites on the molecular chaperones and we have a significant interest in discovering inhibitors of "difficult" targets. We hope to better understand the logic of protein folding and misfolding and use this information to design more effective therapies.


    Collapse Research 
    Collapse Research Activities and Funding
    Activation of the 20S Proteasome to Normalize Tau Homeostasis
    NIH/NIA R21AG053619Aug 15, 2016 - May 31, 2018
    Role: Principal Investigator
    Exploration of Molecular Chaperone Complexes During Active Protein Triage
    NIH/NIGMS R01GM109896Jun 1, 2014 - Feb 28, 2018
    Role: Co-Principal Investigator
    Chemical Probes and Chaperone-Accelerated Turnover of Tau
    NIH/NIA R21AG042813Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator
    Natural Product-Inspired Method for Enhancing HIV Protease Inhibitors
    NIH/NIAID R21AI098431Feb 1, 2012 - Jan 31, 2014
    Role: Principal Investigator
    Molecular Chaperones and Small Molecules
    NIH/NINDS R01NS059690Feb 1, 2008 - Jul 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rauch JN, Olson SH, Gestwicki J. Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules. Cold Spring Harb Perspect Med. 2017 Jul 05; 7(7). PMID: 27940599.
      View in: PubMed
    2. Zuiderweg ER, Hightower LE, Gestwicki J. The remarkable multivalency of the Hsp70 chaperones. Cell Stress Chaperones. 2017 Mar; 22(2):173-189. PMID: 28220454.
      View in: PubMed
    3. Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki J. BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. J Mol Biol. 2017 Jan 06; 429(1):128-141. PMID: 27884606.
      View in: PubMed
    4. Zuiderweg ER, Gestwicki J. Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state. Biomol NMR Assign. 2017 Apr; 11(1):11-15. PMID: 27699616.
      View in: PubMed
    5. Costa MD, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki J, Todi SV, Ivanova MI, Paulson HL. Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain. 2016 Sep 19. PMID: 27645800.
      View in: PubMed
    6. Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res. 2016 Oct 15; 76(20):5926-5932. PMID: 27503927.
      View in: PubMed
    7. Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki J. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 Aug 18; 23(8):992-1001. PMID: 27499529; PMCID: PMC4992411 [Available on 08/18/17].
    8. Rauch JN, Zuiderweg ER, Gestwicki J. Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release. J Biol Chem. 2016 Sep 16; 291(38):19848-57. PMID: 27474739.
      View in: PubMed
    9. Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues B, Dickey CA, Gestwicki J, Kennedy RT. Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis. Anal Chem. 2016 Aug 16; 88(16):8272-8. PMID: 27434096.
      View in: PubMed
    10. Dunyak BM, Gestwicki J. Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. J Med Chem. 2016 Nov 10; 59(21):9622-9644. PMID: 27409354.
      View in: PubMed
    11. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki J, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 09; 113(32):9015-20. PMID: 27450084; PMCID: PMC4987817 [Available on 02/09/17].
    12. Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki J, Cuervo AM, Zuiderweg ER, Santambrogio L. Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy. J Biol Chem. 2016 Aug 26; 291(35):18096-106. PMID: 27405763; PMCID: PMC5000059 [Available on 08/26/17].
    13. Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki J, Dickey CA. Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. ACS Chem Biol. 2016 Jul 15; 11(7):2041-8. PMID: 27177119.
      View in: PubMed
    14. Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki J, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 May 19; 23(5):561-566. PMID: 27203376.
      View in: PubMed
    15. Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki J, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents. 2016 Apr; 47(4):289-96. PMID: 27013001; PMCID: PMC4833571 [Available on 04/01/17].
    16. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977 [Available on 01/21/17].
    17. Li X, Shao H, Taylor IR, Gestwicki J. Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70). Curr Top Med Chem. 2016; 16(25):2729-40. PMID: 27072701.
      View in: PubMed
    18. Assimon VA, Southworth DR, Gestwicki J. Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation. Biochemistry. 2015 Dec 08; 54(48):7120-31. PMID: 26565746; PMCID: PMC4714923 [Available on 12/08/16].
    19. Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki J, Andino R, Fernandez-Sesma A, Frydman J. Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell. 2015 Nov 19; 163(5):1108-1123. PMID: 26582131; PMCID: PMC4869517 [Available on 11/19/16].
    20. Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki J. Pharmacological chaperone for a-crystallin partially restores transparency in cataract models. Science. 2015 Nov 06; 350(6261):674-7. PMID: 26542570; PMCID: PMC4725592 [Available on 11/06/16].
    21. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. PMID: 26390242; PMCID: PMC4598295.
    22. Dunyak BM, Nakamura RL, Frankel AD, Gestwicki J. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins. ACS Chem Biol. 2015 Nov 20; 10(11):2441-7. PMID: 26322864; PMCID: PMC4714926 [Available on 11/20/16].
    23. Cesa LC, Mapp AK, Gestwicki J. Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks. Front Bioeng Biotechnol. 2015; 3:119. PMID: 26380257; PMCID: PMC4547496.
    24. Guan S, Trnka MJ, Bushnell DA, Robinson PJ, Gestwicki J, Burlingame AL. Deconvolution method for specific and nonspecific binding of ligand to multiprotein complex by native mass spectrometry. Anal Chem. 2015 Aug 18; 87(16):8541-6. PMID: 26189511; PMCID: PMC4714924.
    25. Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki J, Zweckstetter M, Dickey CA. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Hum Mol Genet. 2015 Jul 15; 24(14):3971-81. PMID: 25882706; PMCID: PMC4560066.
    26. Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM, Zuiderweg ER, Gestwicki J, Dickey CA. Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. J Biol Chem. 2015 May 22; 290(21):13115-27. PMID: 25864199; PMCID: PMC4505567.
    27. Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki J. Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity. Medchemcomm. 2015 May 01; 6(5):912-918. PMID: 27087913.
      View in: PubMed
    28. Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki J, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. ACS Chem Biol. 2015 Apr 17; 10(4):1099-109. PMID: 25588114; PMCID: PMC4971885.
    29. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki J. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440; PMCID: PMC4456214.
    30. Evans CG, Gestwicki J. Correction to enantioselective organocatalytic hantzsch synthesis of polyhydroquinolines. Org Lett. 2014 Nov 21; 16(22):6040. PMID: 25275212; PMCID: PMC4198511.
    31. Pratt WB, Gestwicki J, Osawa Y, Lieberman AP. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annu Rev Pharmacol Toxicol. 2015; 55:353-71. PMID: 25292434; PMCID: PMC4372135.
    32. Jaeger AM, Makley LN, Gestwicki J, Thiele DJ. Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity. J Biol Chem. 2014 Oct 31; 289(44):30459-69. PMID: 25204655; PMCID: PMC4215228.
    33. Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki J, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. J Neuroinflammation. 2014 Sep 03; 11:152. PMID: 25183004; PMCID: PMC4167523.
    34. Rauch JN, Gestwicki J. Rehabilitating mutant GCase. Chem Biol. 2014 Aug 14; 21(8):919-20. PMID: 25126987.
      View in: PubMed
    35. Ung PM, Dunbar JB, Gestwicki J, Carlson HA. An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases. J Med Chem. 2014 Aug 14; 57(15):6468-78. PMID: 25062388; PMCID: PMC4136727.
    36. Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki J, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 01; 74(17):4731-40. PMID: 24994713; PMCID: PMC4174322.
    37. Pratt WB, Morishima Y, Gestwicki J, Lieberman AP, Osawa Y. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Exp Biol Med (Maywood). 2014 Nov; 239(11):1405-13. PMID: 24990484; PMCID: PMC4318483.
    38. Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki J. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chem Biol Drug Des. 2014 Apr; 83(4):440-9. PMID: 24636344; PMCID: PMC4068144.
    39. Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki J, Sun D. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. J Biol Chem. 2014 Jan 31; 289(5):2908-17. PMID: 24327656; PMCID: PMC3908423.
    40. Rauch JN, Gestwicki J. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17; 289(3):1402-14. PMID: 24318877; PMCID: PMC3894324.
    41. Ung PM, Thompson AD, Chang L, Gestwicki J, Carlson HA. Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. PLoS Comput Biol. 2013; 9(11):e1003279. PMID: 24277995; PMCID: PMC3836694.
    42. Li X, Srinivasan SR, Connarn J, Ahmad A, Young ZT, Kabza AM, Zuiderweg ER, Sun D, Gestwicki J. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14; 4(11). PMID: 24312699.
      View in: PubMed
    43. Rauch JN, Nie J, Buchholz TJ, Gestwicki J, Kennedy RT. Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions. Anal Chem. 2013 Oct 15; 85(20):9824-31. PMID: 24060167; PMCID: PMC3845662.
    44. Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki J, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 2013 Aug 13; 52(32):5354-64. PMID: 23865999; PMCID: PMC3856692.
    45. Cesa LC, Patury S, Komiyama T, Ahmad A, Zuiderweg ER, Gestwicki J. Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes. ACS Chem Biol. 2013 Sep 20; 8(9):1988-1997. PMID: 23819499; PMCID: PMC3783524.
    46. Dunbar JB, Smith RD, Damm-Ganamet KL, Ahmed A, Esposito EX, Delproposto J, Chinnaswamy K, Kang YN, Kubish G, Gestwicki J, Stuckey JA, Carlson HA. CSAR data set release 2012: ligands, affinities, complexes, and docking decoys. J Chem Inf Model. 2013 Aug 26; 53(8):1842-52. PMID: 23617227; PMCID: PMC3753885.
    47. Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki J, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry. 2013 Sep 01; 74(5):367-74. PMID: 23607970; PMCID: PMC3740016.
    48. Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki J. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19; 4(6):930-9. PMID: 23472668; PMCID: PMC3689201.
    49. Makley LN, Gestwicki J. Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions. Chem Biol Drug Des. 2013 Jan; 81(1):22-32. PMID: 23253128; PMCID: PMC3531880.
    50. Assimon VA, Gillies AT, Rauch JN, Gestwicki J. Hsp70 protein complexes as drug targets. Curr Pharm Des. 2013; 19(3):404-17. PMID: 22920901; PMCID: PMC3593251.
    51. Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki J, Ahmad A. Allostery in the Hsp70 chaperone proteins. Top Curr Chem. 2013; 328:99-153. PMID: 22576356; PMCID: PMC3623542.
    52. Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki J, Zweckstetter M, Dickey CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J. 2013 Apr; 27(4):1450-9. PMID: 23271055; PMCID: PMC3606536.
    53. Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki J, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol. 2013 Feb; 9(2):112-8. PMID: 23222885; PMCID: PMC3552084.
    54. Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki J. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol. 2012 Nov 21; 19(11):1391-9. PMID: 23177194; PMCID: PMC3508472.
    55. Gillies AT, Taylor R, Gestwicki J. Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones. Mol Biosyst. 2012 Nov; 8(11):2901-8. PMID: 22851130; PMCID: PMC3463740.
    56. Davis MJ, Gregorka B, Gestwicki J, Swanson JA. Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. J Immunol. 2012 Nov 01; 189(9):4488-95. PMID: 23002437; PMCID: PMC3478491.
    57. Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki J, Brodsky JL. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res. 2012 Oct; 96(1):70-81. PMID: 22898086; PMCID: PMC3465505.
    58. Smith MC, Gestwicki J. Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med. 2012 Jul 26; 14:e16. PMID: 22831787; PMCID: PMC3591511.
    59. Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki J. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chem Biol. 2012 Oct 19; 7(10):1677-86. PMID: 22769591; PMCID: PMC3477299.
    60. Thompson AD, Dugan A, Gestwicki J, Mapp AK. Fine-tuning multiprotein complexes using small molecules. ACS Chem Biol. 2012 Aug 17; 7(8):1311-20. PMID: 22725693; PMCID: PMC3517816.
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