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Yifan Cheng, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #S472D
San Francisco CA 94158
Phone415-514-9708
ORCID ORCID Icon0000-0001-9535-0369 Additional info
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    Collapse Biography 
    Collapse education and training
    Institute of Physics, Chinese Academy of Sciences, Beijing, ChinaPh.D.1991Condensed Matter Physics
    Wuhan University, Wuhan, ChinaM.Sc.1987Solid State Physics
    Wuhan University, Wuhan, ChinaB.Sc1982Semiconductor Physics
    Collapse awards and honors
    The Protein Society2018Christian B. Anfinsen Award
    American Academy of Arts and Sciences2019Elected member
    National Academy of Sciences2020Elected Member
    Wuhan University2020Outstanding Alumni
    Vanderbilt University2023Discovery Lecture

    Collapse Overview 
    Collapse overview
    We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). A full understanding of the biological functions/processes of any macromolecular complex requires structural information at a wide range of resolutions, including atomic details of its components, spatial arrangements of these components and interactions between them. CryoEM can be used to study macromolecules in their native conformations at a wide resolution range, from sub-nanometer resolution (single particle cryoEM) to the cellular level (electron tomography).

    Collapse Research 
    Collapse research activities and funding
    Advancing cryo-EM technology to address difficult biological questions
    NIH R35GM140847Apr 1, 2021 - Feb 28, 2026
    Role: Principal Investigator
    Structural mechanism of integrin-mediated TGF-b activation
    NIH R01HL134183Jul 4, 2016 - May 31, 2024
    Role: Co-Principal Investigator
    Acquisition of an electron microscope for high-resolution single particle cryo-EM
    NIH S10OD021741May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    Mapping the conformational cycle of transmembrane transporters
    NIH P01GM111126Aug 1, 2015 - Jul 31, 2020
    Role: Co-Investigator
    Linux cluster for near atomic resolution single particle cryo-EM
    NIH S10OD020054Apr 15, 2015 - Apr 14, 2016
    Role: Principal Investigator
    Structures and gating mechanisms of TRP ion channels
    NIH R01GM098672Aug 1, 2011 - Jun 30, 2020
    Role: Principal Investigator
    GPU Computing Enabled Linux Computer Cluster
    NIH S10RR026814Jan 28, 2010 - Jan 27, 2012
    Role: Principal Investigator
    Mechanism of gate-opening in the 20S proteasome induced by the proteasomal ATPase
    NIH R01GM082893Jan 1, 2008 - Mar 31, 2019
    Role: Principal Investigator
    HARC Center: HIV Accessory and Regulatory Complexes
    NIH P50GM082250Aug 27, 2007 - Aug 31, 2022
    Role: Co-Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition. Mol Cell. 2025 Aug 21; 85(16):3108-3122.e7. Smith AM, Li Y, Velarde A, Cheng Y, Frankel AD. PMID: 40845804; PMCID: PMC12410093.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Structural dynamics of human fatty acid synthase in the condensing cycle. Nature. 2025 May; 641(8062):529-536. Choi W, Li C, Chen Y, Wang Y, Cheng Y. PMID: 39978408; PMCID: PMC12058526.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex. Nat Commun. 2025 Jan 28; 16(1):1100. Bi M, Wang X, Wang J, Xu J, Sun W, Adediwura VA, Miao Y, Cheng Y, Ye L. PMID: 39875358; PMCID: PMC11775185.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Dynamic allostery drives autocrine and paracrine TGF-β signaling. Cell. 2024 Oct 31; 187(22):6200-6219.e23. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. PMID: 39288764; PMCID: PMC11531391.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat Struct Mol Biol. 2024 Sep; 31(9):1377-1385. Arnold WR, Mancino A, Moss FR, Frost A, Julius D, Cheng Y. PMID: 38698206; PMCID: PMC11402599.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    6. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun. 2024 Mar 12; 15(1):2225. Chio US, Palovcak E, Smith AAA, Autzen H, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. PMID: 38472177; PMCID: PMC10933330.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    7. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun. 2023 08 12; 14(1):4874. Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY. PMID: 37573365; PMCID: PMC10423226.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    8. A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM. STAR Protoc. 2022 12 16; 3(4):101732. Zhang K, Julius D, Cheng Y. PMID: 36181684; PMCID: PMC9530669.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    9. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature. 2022 09; 609(7928):846-853. Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. PMID: 35940205; PMCID: PMC9678024.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    10. Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun. 2022 07 28; 13(1):4366. Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y. PMID: 35902590; PMCID: PMC9334595.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    11. Sensory TRP Channels in Three Dimensions. Annu Rev Biochem. 2022 06 21; 91:629-649. Diver MM, Lin King JV, Julius D, Cheng Y. PMID: 35287474; PMCID: PMC9233036.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    12. Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat Chem Biol. 2022 01; 18(1):109-115. Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A. PMID: 34711980; PMCID: PMC8712391.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    13. Dispatched uses Na+ flux to power release of lipid-modified Hedgehog. Nature. 2021 11; 599(7884):320-324. Wang Q, Asarnow DE, Ding K, Mann RK, Hatakeyama J, Zhang Y, Ma Y, Cheng Y, Beachy PA. PMID: 34707294; PMCID: PMC8785653.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell. 2021 09 30; 184(20):5138-5150.e12. Zhang K, Julius D, Cheng Y. PMID: 34496225; PMCID: PMC8488022.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    15. Allosteric coupling between α-rings of the 20S proteasome. Nat Commun. 2020 09 11; 11(1):4580. Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y. PMID: 32917864; PMCID: PMC7486400.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    16. Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry. Mol Cell Proteomics. 2020 12; 19(12):1997-2015. Yu Y, Liu H, Yu Z, Witkowska HE, Cheng Y. PMID: 32883800; PMCID: PMC7710143.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 10; 586(7831):807-811. Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. PMID: 32814342; PMCID: PMC7906036.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    18. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature. 2020 09; 585(7823):141-145. Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. PMID: 32641835; PMCID: PMC7483980.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    19. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. PMID: 31955848; PMCID: PMC7238552.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    20. Structural insights into TRPM8 inhibition and desensitization. Science. 2019 09 27; 365(6460):1434-1440. Diver MM, Cheng Y, Julius D. PMID: 31488702; PMCID: PMC7262954.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    21. Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment. Curr Opin Struct Biol. 2019 10; 58:259-268. Autzen HE, Julius D, Cheng Y. PMID: 31279500; PMCID: PMC6778513.
      View in: PubMed   Mentions: 42     Fields:    
    22. Structural insight into TRPV5 channel function and modulation. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8869-8878. Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J. PMID: 30975749; PMCID: PMC6500171.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    23. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell. 2018 11 15; 175(5):1352-1364.e14. Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA. PMID: 30415841; PMCID: PMC6326742.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    24. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 08; 25(8):698-704. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. PMID: 30061598; PMCID: PMC6214843.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    25. The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA. Elife. 2014 Dec 08; 3:e04121. Booth DS, Cheng Y, Frankel AD. PMID: 25486595; PMCID: PMC4360530.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    26. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 06; 159(4):857-68. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD. PMID: 25417161; PMCID: PMC4269335.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    27. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature. 2015 Jan 15; 517(7534):396-400. Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. PMID: 25363761; PMCID: PMC4372080.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    28. Localization events-based sample drift correction for localization microscopy with redundant cross-correlation algorithm. Opt Express. 2014 Jun 30; 22(13):15982-91. Wang Y, Schnitzbauer J, Hu Z, Li X, Cheng Y, Huang ZL, Huang B. PMID: 24977854; PMCID: PMC4162368.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    29. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194; PMCID: PMC4341974.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    30. Single particle electron cryo-microscopy of a mammalian ion channel. Curr Opin Struct Biol. 2014 Aug; 27:1-7. Liao M, Cao E, Julius D, Cheng Y. PMID: 24681231; PMCID: PMC4176607.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    31. Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5189-94. Lu J, Yu Y, Zhu I, Cheng Y, Sun PD. PMID: 24706838; PMCID: PMC3986191.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    32. CTER-rapid estimation of CTF parameters with error assessment. Ultramicroscopy. 2014 May; 140:9-19. Penczek PA, Fang J, Li X, Cheng Y, Loerke J, Spahn CM. PMID: 24562077; PMCID: PMC4016771.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    33. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 05; 504(7478):107-12. Liao M, Cao E, Julius D, Cheng Y. PMID: 24305160; PMCID: PMC4078027.
      View in: PubMed   Mentions: 863     Fields:    Translation:HumansAnimalsCells
    34. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature. 2013 Dec 05; 504(7478):113-8. Cao E, Liao M, Cheng Y, Julius D. PMID: 24305161; PMCID: PMC4023639.
      View in: PubMed   Mentions: 554     Fields:    Translation:AnimalsCells
    35. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. PMID: 24210660; PMCID: PMC3974617.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    36. Influence of electron dose rate on electron counting images recorded with the K2 camera. J Struct Biol. 2013 Nov; 184(2):251-60. Li X, Zheng SQ, Egami K, Agard DA, Cheng Y. PMID: 23968652; PMCID: PMC3854003.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    37. Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell. 2013 May 23; 153(5):1012-24. Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB. PMID: 23706739; PMCID: PMC3983474.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    38. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. PMID: 23644457; PMCID: PMC3687086.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    39. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods. 2013 Jun; 10(6):584-90. Li X, Mooney P, Zheng S, Booth CR, Braunfeld MB, Gubbens S, Agard DA, Cheng Y. PMID: 23644547; PMCID: PMC3684049.
      View in: PubMed   Mentions: 1053     Fields:    Translation:Cells
    40. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. PMID: 23485968; PMCID: PMC3907283.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    41. Recording high-resolution images of two-dimensional crystals of membrane proteins. Methods Mol Biol. 2013; 955:129-52. Avila-Sakar A, Li X, Zheng SQ, Cheng Y. PMID: 23132059.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. A method for integrative structure determination of protein-protein complexes. Bioinformatics. 2012 Dec 15; 28(24):3282-9. Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A. PMID: 23093611; PMCID: PMC3519461.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    43. Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils. Biomacromolecules. 2012 Nov 12; 13(11):3494-502. Martinez-Avila O, Wu S, Kim SJ, Cheng Y, Khan F, Samudrala R, Sali A, Horst JA, Habelitz S. PMID: 22974364; PMCID: PMC3496023.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    44. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. PMID: 22483106; PMCID: PMC3322386.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    45. Visualizing proteins and macromolecular complexes by negative stain EM: from grid preparation to image acquisition. J Vis Exp. 2011 Dec 22; (58). Booth DS, Avila-Sakar A, Cheng Y. PMID: 22215030; PMCID: PMC3369646.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    46. Self-assembly of amelogenin proteins at the water-oil interface. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:75-82. Martinez-Avila OM, Wu S, Cheng Y, Lee R, Khan F, Habelitz S. PMID: 22243231; PMCID: PMC6339812.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    47. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26. Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. PMID: 21489994; PMCID: PMC3121472.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimalsCells
    48. A distributed multi-GPU system for high speed electron microscopic tomographic reconstruction. Ultramicroscopy. 2011 Jul; 111(8):1137-43. Zheng SQ, Branlund E, Kesthelyi B, Braunfeld MB, Cheng Y, Sedat JW, Agard DA. PMID: 21741915; PMCID: PMC3190582.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    49. Self-aligning amelogenin nanoribbons in oil-water system. J Struct Biol. 2011 Apr; 174(1):203-12. He X, Wu S, Martinez-Avila O, Cheng Y, Habelitz S. PMID: 21134461; PMCID: PMC3204882.
      View in: PubMed   Mentions: 23     Fields:    
    50. Structure characterization of the 26S proteasome. Biochim Biophys Acta. 2011 Feb; 1809(2):67-79. Kim HM, Yu Y, Cheng Y. PMID: 20800708; PMCID: PMC3010250.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    51. HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12481-6. Daugherty MD, Booth DS, Jayaraman B, Cheng Y, Frankel AD. PMID: 20616058; PMCID: PMC2906596.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    52. GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors. J Struct Biol. 2010 Dec; 172(3):407-12. Li X, Grigorieff N, Cheng Y. PMID: 20558298; PMCID: PMC2964447.
      View in: PubMed   Mentions: 22     Fields:    
    53. Collecting electron crystallographic data of two-dimensional protein crystals. Methods Enzymol. 2010; 481:251-82. Hite RK, Schenk AD, Li Z, Cheng Y, Walz T. PMID: 20887861.
      View in: PubMed   Mentions: 6     Fields:    
    54. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic. 2010 Jan; 11(1):110-22. Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM. PMID: 19912576; PMCID: PMC2796297.
      View in: PubMed   Mentions: 328     Fields:    Translation:HumansCells
    55. The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature. 2009 Dec 24; 462(7276):1016-21. Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ. PMID: 20033039; PMCID: PMC2869534.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    56. Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J. 2010 Feb 03; 29(3):692-702. Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y. PMID: 20019667; PMCID: PMC2830694.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    57. Evaluation of imaging plates as recording medium for images of negatively stained single particles and electron diffraction patterns of two-dimensional crystals. J Electron Microsc (Tokyo). 2010; 59(1):53-63. Li Z, Hite RK, Cheng Y, Walz T. PMID: 19643814; PMCID: PMC3156676.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    58. Toward an atomic model of the 26S proteasome. Curr Opin Struct Biol. 2009 Apr; 19(2):203-8. Cheng Y. PMID: 19286367; PMCID: PMC2743420.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    59. A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis. Biochim Biophys Acta. 2009 May; 1793(5):772-80. Kim HZ, Jung K, Kim HM, Cheng Y, Koh GY. PMID: 19339208.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    60. The advent of near-atomic resolution in single-particle electron microscopy. Annu Rev Biochem. 2009; 78:723-42. Cheng Y, Walz T. PMID: 19489732.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    61. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell. 2008 May 09; 30(3):360-8. Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y. PMID: 18471981; PMCID: PMC4141531.
      View in: PubMed   Mentions: 231     Fields:    Translation:AnimalsCells
    62. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3739-44. Frey G, Peng H, Rits-Volloch S, Morelli M, Cheng Y, Chen B. PMID: 18322015; PMCID: PMC2268799.
      View in: PubMed   Mentions: 167     Fields:    Translation:Cells
    63. In vitro self-assembly of tailorable nanotubes from a simple protein building block. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3733-8. Ballister ER, Lai AH, Zuckermann RN, Cheng Y, Mougous JD. PMID: 18310321; PMCID: PMC2268831.
      View in: PubMed   Mentions: 117     Fields:    Translation:Cells
    64. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell. 2007 Dec 14; 28(5):871-85. Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T. PMID: 18082611; PMCID: PMC2197158.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    65. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20. J Mol Biol. 2008 Feb 15; 376(2):380-92. Gonen T, Hite RK, Cheng Y, Petre BM, Kistler J, Walz T. PMID: 18166196.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    66. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell. 2007 Sep 07; 27(5):731-44. Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL. PMID: 17803938; PMCID: PMC2083707.
      View in: PubMed   Mentions: 307     Fields:    Translation:AnimalsCells
    67. Reconstructing the endocytotic machinery. Methods Cell Biol. 2007; 79:463-87. Cheng Y, Walz T. PMID: 17327169.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    68. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9. Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T. PMID: 17095010; PMCID: PMC1839968.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    69. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity. 2006 Oct; 25(4):583-94. Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA. PMID: 17045822.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    70. Electron tomography of swollen rigor fibers of insect flight muscle reveals a short and variably angled S2 domain. J Mol Biol. 2006 Sep 29; 362(4):844-60. Liu J, Wu S, Reedy MC, Winkler H, Lucaveche C, Cheng Y, Reedy MK, Taylor KA. PMID: 16949613.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    71. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. PMID: 16908193; PMCID: PMC2910098.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    72. Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins. Biol Chem. 2006 Feb; 387(2):179-87. Nakagawa T, Cheng Y, Sheng M, Walz T. PMID: 16497150.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    73. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell. 2005 Dec 09; 20(5):687-98. Smith DM, Kafri G, Cheng Y, Ng D, Walz T, Goldberg AL. PMID: 16337593.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    74. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 01; 438(7068):633-8. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T. PMID: 16319884; PMCID: PMC1350984.
      View in: PubMed   Mentions: 329     Fields:    Translation:AnimalsCells
    75. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 03; 355(5):1048-65. Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T. PMID: 16343539.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    76. Single particle reconstruction of the human apo-transferrin-transferrin receptor complex. J Struct Biol. 2005 Dec; 152(3):204-10. Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. PMID: 16343946.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    77. Structure and different conformational states of native AMPA receptor complexes. Nature. 2005 Feb 03; 433(7025):545-9. Nakagawa T, Cheng Y, Ramm E, Sheng M, Walz T. PMID: 15690046.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    78. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. PMID: 15502812.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    79. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. PMID: 15502813.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    80. Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol. 2004 Sep 24; 342(4):1337-45. Gonen T, Cheng Y, Kistler J, Walz T. PMID: 15351655.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    81. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13; 429(6988):193-7. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. PMID: 15141214.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    82. A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol. 2004 May; 78(9):4508-16. Chen B, Cheng Y, Calder L, Harrison SC, Reinherz EL, Skehel JJ, Wiley DC. PMID: 15078931; PMCID: PMC387710.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    83. Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online. 2004; 6:23-34. Ohi M, Li Y, Cheng Y, Walz T. PMID: 15103397; PMCID: PMC389902.
      View in: PubMed   Mentions: 423  
    84. Structure of the human transferrin receptor-transferrin complex. Cell. 2004 Feb 20; 116(4):565-76. Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. PMID: 14980223.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    85. The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell. 2003 Nov; 12(5):1113-23. Toth EA, Li Y, Sawaya MR, Cheng Y, Ellenberger T. PMID: 14636571.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    86. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10704-9. Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T. PMID: 11535824; PMCID: PMC58530.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    87. The three-dimensional map of microsomal glutathione transferase 1 at 6 A resolution. EMBO J. 2000 Dec 01; 19(23):6311-6. Schmidt-Krey I, Mitsuoka K, Hirai T, Murata K, Cheng Y, Fujiyoshi Y, Morgenstern R, Hebert H. PMID: 11101503; PMCID: PMC305867.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    88. The projection structure of the membrane protein microsomal glutathione transferase at 3 A resolution as determined from two-dimensional hexagonal crystals. J Mol Biol. 1999 Apr 30; 288(2):243-53. Schmidt-Krey I, Murata K, Hirai T, Mitsuoka K, Cheng Y, Morgenstern R, Fujiyoshi Y, Hebert H. PMID: 10329140.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    89. Influence of various nucleotides on the in situ crystallization of Ca2+-ATPase. Biochim Biophys Acta. 1999 Jan 08; 1415(2):361-8. Hiroaki Y, Mitsuoka K, Cheng Y, Hiroaki H, Fujiyoshi Y. PMID: 9889398.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    90. Characterization of the low magnification performance of a Philips CM300-FEG. Ultramicroscopy. 1998 Sep; 74(4):209-20. Cheng Y, Taylor KA. PMID: 9809458.
      View in: PubMed   Mentions:    Fields:    
    91. The use of electron tomography for structural analysis of disordered protein arrays. J Struct Biol. 1997 Dec; 120(3):372-86. Taylor KA, Tang J, Cheng Y, Winkler H. PMID: 9441940.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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