Yifan Cheng, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #S472D
San Francisco CA 94158
ORCID ORCID Icon0000-0001-9535-0369 Additional info
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    Collapse Overview 
    Collapse overview
    We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). A full understanding of the biological functions/processes of any macromolecular complex requires structural information at a wide range of resolutions, including atomic details of its components, spatial arrangements of these components and interactions between them. CryoEM can be used to study macromolecules in their native conformations at a wide resolution range, from sub-nanometer resolution (single particle cryoEM) to the cellular level (electron tomography).

    Collapse Biography 
    Collapse education and training
    Institute of Physics, Chinese Academy of Sciences, Beijing, ChinaPh.D.1991Condensed Matter Physics
    Wuhan University, Wuhan, ChinaM.Sc.1987Solid State Physics
    Wuhan University, Wuhan, ChinaB.Sc1982Semiconductor Physics
    Collapse awards and honors
    The Protein Society2018Christian B. Anfinsen Award
    American Academy of Arts and Sciences2019Elected member
    National Academy of Sciences2020Elected Member
    Wuhan University2020Outstanding Alumni
    Vanderbilt University2023Discovery Lecture

    Collapse Research 
    Collapse research activities and funding
    Conformational regulation of TGF-? activation by integrin av?6
    NIH R01HL165175Jul 1, 2023 - Jun 30, 2027
    Role: Co-Principal Investigator
    Advancing cryo-EM technology to address difficult biological questions
    NIH R35GM140847Apr 1, 2021 - Feb 28, 2031
    Role: Principal Investigator
    Structural mechanism of integrin-mediated TGF-b activation
    NIH R01HL134183Jul 4, 2016 - Feb 28, 2030
    Role: Co-Principal Investigator
    Acquisition of an electron microscope for high-resolution single particle cryo-EM
    NIH S10OD021741May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    Mapping the conformational cycle of transmembrane transporters
    NIH P01GM111126Aug 1, 2015 - Jul 31, 2020
    Role: Co-Investigator
    Linux cluster for near atomic resolution single particle cryo-EM
    NIH S10OD020054Apr 15, 2015 - Apr 14, 2016
    Role: Principal Investigator
    Structures and gating mechanisms of TRP ion channels
    NIH R01GM098672Aug 1, 2011 - Jun 30, 2020
    Role: Principal Investigator
    GPU Computing Enabled Linux Computer Cluster
    NIH S10RR026814Jan 28, 2010 - Jan 27, 2012
    Role: Principal Investigator
    Mechanism of gate-opening in the 20S proteasome induced by the proteasomal ATPase
    NIH R01GM082893Jan 1, 2008 - Mar 31, 2019
    Role: Principal Investigator
    HARC Center: HIV Accessory and Regulatory Complexes
    NIH P50GM082250Aug 27, 2007 - Aug 31, 2022
    Role: Co-Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Substrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages. ACS Chem Biol. 2026 Sep 18; 21(9):2275-2285. Gu X, Rowheder PJ, Yu Z, Mohapatra A, Lun S, Jiang X, Li D, Yan NL, Detomasi TC, Pomares DFT, Chen Y, Gestwicki JE, Lin G, Bishai WR, Ernst JD, Cheng Y, Craik CS, Sello JK. PMID: 42906009.
      View in: PubMed   Mentions:
    2. Antibody reveals conformational latch regulating dimerization in β- and γ-herpesvirus proteases. Nat Commun. 2026 Jul 13; 17(1). Zimanyi MA, Hulce KR, Bohn MF, Norman J, Rohweder PJ, Detomasi TC, Cheng Y, Craik CS. PMID: 42443199; PMCID: PMC13486704.
      View in: PubMed   Mentions:    Fields:    
    3. Structure of the E3 ligase CRL2ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination. Cell Rep. 2026 Jun 23; 45(6):117401. Liu X, Li Y, Castro LK, Yu Z, Cheng Y, Daugherty MD, Gross JD. PMID: 42224082; PMCID: PMC13379236.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Making sense of invisible densities in single-particle cryo-EM. IUCrJ. 2026 May 01; 13(Pt 3):217-220. Lin X, Cheng Y. PMID: 42028876; PMCID: PMC13134491.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells. Cell. 2026 Jun 11; 189(12):3651-3668.e31. Rathore U, Dugan E, Thornton H, Kumar VE, Dajani R, Burdick RC, Young JM, Steinhart Z, Lao R, Delviks-Frankenberry KA, Choi W, Henriques WS, Echeverria I, Dann E, Dureja I, Pathak N, Arce MM, McKetney J, Umhoefer JM, Parulekar S, Schmidt R, Polacco BJ, Neidleman J, Montano M, Nguyen VQ, Sali A, Levy JA, Tenthorey JL, Cheng Y, Roan NR, Swaney DL, Kaake RM, Dodgson SE, Hiatt J, Pathak VK, Malik HS, Krogan NJ, Marson A. PMID: 42013838; PMCID: PMC13105272.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction. Sci Adv. 2026 Apr 03; 12(14):eaeb6165. Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y. PMID: 41921004; PMCID: PMC13041742.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Structural energetics of cold sensitivity. Nature. 2026 May; 653(8115):962-970. Choi KY, Lin X, Cheng Y, Julius D. PMID: 41882351; PMCID: PMC13190261.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Latent-TGF-β has a domain swapped architecture. Nat Commun. 2025 Nov 25; 16(1):10469. Jin M, Seed RI, Shing T, Wang L, Li J, Cheng Y, Nishimura SL. PMID: 41290649; PMCID: PMC12647607.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis. Mol Cell. 2025 Dec 04; 85(23):4437-4451.e11. Zheng F, Yu Z, Zhuang J, Vannur L, Nickols W, Wang Y, Li L, Tan SJO, Yoo S, Cheng Y, Zhou C. PMID: 41202813; PMCID: PMC12721022.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition. Mol Cell. 2025 Aug 21; 85(16):3108-3122.e7. Smith AM, Li Y, Velarde A, Cheng Y, Frankel AD. PMID: 40845804; PMCID: PMC12410093.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. HMGB1 deforms nucleosomal DNA to generate a dynamic chromatin environment counteracting the effects of linker histone. Sci Adv. 2025 08 15; 11(33):eads4473. Saunders HS, Chio US, Moore CM, Ramani V, Cheng Y, Narlikar GJ. PMID: 40815652; PMCID: PMC12356256.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning. Science. 2025 07 17; 389(6757):eadr3831. Kaur U, Wu H, Cheng Y, Narlikar GJ. PMID: 40674492; PMCID: PMC12403922.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Structural dynamics of human fatty acid synthase in the condensing cycle. Nature. 2025 05; 641(8062):529-536. Choi W, Li C, Chen Y, Wang Y, Cheng Y. PMID: 39978408; PMCID: PMC12058526.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex. Nat Commun. 2025 Jan 28; 16(1):1100. Bi M, Wang X, Wang J, Xu J, Sun W, Adediwura VA, Miao Y, Cheng Y, Ye L. PMID: 39875358; PMCID: PMC11775185.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Dynamic allostery drives autocrine and paracrine TGF-β signaling. Cell. 2024 Oct 31; 187(22):6200-6219.e23. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. PMID: 39288764; PMCID: PMC11531391.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    16. A systematic search for RNA structural switches across the human transcriptome. Nat Methods. 2024 Sep; 21(9):1634-1645. Khoroshkin M, Asarnow D, Zhou S, Navickas A, Winters A, Goudreau J, Zhou SK, Yu J, Palka C, Fish L, Borah A, Yousefi K, Carpenter C, Ansel KM, Cheng Y, Gilbert LA, Goodarzi H. PMID: 39014073; PMCID: PMC11399106.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination. bioRxiv. 2024 Jun 24. Liu X, Li Y, Castro L, Yu Z, Cheng Y, Daugherty MD, Gross JD. PMID: 38979164; PMCID: PMC11230176.
      View in: PubMed   Mentions:
    18. Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat Struct Mol Biol. 2024 Sep; 31(9):1377-1385. Arnold WR, Mancino A, Moss FR, Frost A, Julius D, Cheng Y. PMID: 38698206; PMCID: PMC11402599.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    19. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun. 2024 Mar 12; 15(1):2225. Chio US, Palovcak E, Smith AAA, Autzen H, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. PMID: 38472177; PMCID: PMC10933330.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    20. Structural basis of prostaglandin efflux by MRP4. Nat Struct Mol Biol. 2024 Apr; 31(4):621-632. Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM. PMID: 38216659; PMCID: PMC11145372.
      View in: PubMed   Mentions: 11     Fields:    
    21. Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein. J Biol Chem. 2023 12; 299(12):105362. Adly AN, Bi M, Carlson CR, Syed AM, Ciling A, Doudna JA, Cheng Y, Morgan DO. PMID: 37863261; PMCID: PMC10665939.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    22. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun. 2023 08 12; 14(1):4874. Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY. PMID: 37573365; PMCID: PMC10423226.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    23. A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM. STAR Protoc. 2022 12 16; 3(4):101732. Zhang K, Julius D, Cheng Y. PMID: 36181684; PMCID: PMC9530669.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    24. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature. 2022 09; 609(7928):846-853. Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. PMID: 35940205; PMCID: PMC9678024.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    25. Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun. 2022 07 28; 13(1):4366. Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y. PMID: 35902590; PMCID: PMC9334595.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    26. Sensory TRP Channels in Three Dimensions. Annu Rev Biochem. 2022 06 21; 91:629-649. Diver MM, Lin King JV, Julius D, Cheng Y. PMID: 35287474; PMCID: PMC9233036.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    27. Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat Chem Biol. 2022 01; 18(1):109-115. Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A. PMID: 34711980; PMCID: PMC8712391.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    28. Dispatched uses Na+ flux to power release of lipid-modified Hedgehog. Nature. 2021 11; 599(7884):320-324. Wang Q, Asarnow DE, Ding K, Mann RK, Hatakeyama J, Zhang Y, Ma Y, Cheng Y, Beachy PA. PMID: 34707294; PMCID: PMC8785653.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    29. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell. 2021 09 30; 184(20):5138-5150.e12. Zhang K, Julius D, Cheng Y. PMID: 34496225; PMCID: PMC8488022.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    30. Allosteric coupling between α-rings of the 20S proteasome. Nat Commun. 2020 09 11; 11(1):4580. Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y. PMID: 32917864; PMCID: PMC7486400.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    31. Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry. Mol Cell Proteomics. 2020 12; 19(12):1997-2015. Yu Y, Liu H, Yu Z, Witkowska HE, Cheng Y. PMID: 32883800; PMCID: PMC7710143.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    32. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 10; 586(7831):807-811. Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. PMID: 32814342; PMCID: PMC7906036.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    33. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature. 2020 09; 585(7823):141-145. Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. PMID: 32641835; PMCID: PMC7483980.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    34. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. PMID: 31955848; PMCID: PMC7238552.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    35. Structural insights into TRPM8 inhibition and desensitization. Science. 2019 09 27; 365(6460):1434-1440. Diver MM, Cheng Y, Julius D. PMID: 31488702; PMCID: PMC7262954.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    36. Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment. Curr Opin Struct Biol. 2019 10; 58:259-268. Autzen HE, Julius D, Cheng Y. PMID: 31279500; PMCID: PMC6778513.
      View in: PubMed   Mentions: 44     Fields:    
    37. Structural insight into TRPV5 channel function and modulation. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8869-8878. Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J. PMID: 30975749; PMCID: PMC6500171.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    38. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell. 2018 11 15; 175(5):1352-1364.e14. Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA. PMID: 30415841; PMCID: PMC6326742.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    39. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 08; 25(8):698-704. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. PMID: 30061598; PMCID: PMC6214843.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    40. The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA. Elife. 2014 Dec 08; 3:e04121. Booth DS, Cheng Y, Frankel AD. PMID: 25486595; PMCID: PMC4360530.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    41. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 06; 159(4):857-68. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD. PMID: 25417161; PMCID: PMC4269335.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    42. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature. 2015 Jan 15; 517(7534):396-400. Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. PMID: 25363761; PMCID: PMC4372080.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    43. Localization events-based sample drift correction for localization microscopy with redundant cross-correlation algorithm. Opt Express. 2014 Jun 30; 22(13):15982-91. Wang Y, Schnitzbauer J, Hu Z, Li X, Cheng Y, Huang ZL, Huang B. PMID: 24977854; PMCID: PMC4162368.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    44. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194; PMCID: PMC4341974.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    45. Single particle electron cryo-microscopy of a mammalian ion channel. Curr Opin Struct Biol. 2014 Aug; 27:1-7. Liao M, Cao E, Julius D, Cheng Y. PMID: 24681231; PMCID: PMC4176607.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    46. Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5189-94. Lu J, Yu Y, Zhu I, Cheng Y, Sun PD. PMID: 24706838; PMCID: PMC3986191.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    47. CTER-rapid estimation of CTF parameters with error assessment. Ultramicroscopy. 2014 May; 140:9-19. Penczek PA, Fang J, Li X, Cheng Y, Loerke J, Spahn CM. PMID: 24562077; PMCID: PMC4016771.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    48. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 05; 504(7478):107-12. Liao M, Cao E, Julius D, Cheng Y. PMID: 24305160; PMCID: PMC4078027.
      View in: PubMed   Mentions: 889     Fields:    Translation:HumansAnimalsCells
    49. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature. 2013 Dec 05; 504(7478):113-8. Cao E, Liao M, Cheng Y, Julius D. PMID: 24305161; PMCID: PMC4023639.
      View in: PubMed   Mentions: 572     Fields:    Translation:AnimalsCells
    50. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. PMID: 24210660; PMCID: PMC3974617.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    51. Influence of electron dose rate on electron counting images recorded with the K2 camera. J Struct Biol. 2013 Nov; 184(2):251-60. Li X, Zheng SQ, Egami K, Agard DA, Cheng Y. PMID: 23968652; PMCID: PMC3854003.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    52. Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell. 2013 May 23; 153(5):1012-24. Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB. PMID: 23706739; PMCID: PMC3983474.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    53. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. PMID: 23644457; PMCID: PMC3687086.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    54. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods. 2013 Jun; 10(6):584-90. Li X, Mooney P, Zheng S, Booth CR, Braunfeld MB, Gubbens S, Agard DA, Cheng Y. PMID: 23644547; PMCID: PMC3684049.
      View in: PubMed   Mentions: 1066     Fields:    Translation:Cells
    55. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. PMID: 23485968; PMCID: PMC3907283.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    56. Recording high-resolution images of two-dimensional crystals of membrane proteins. Methods Mol Biol. 2013; 955:129-52. Avila-Sakar A, Li X, Zheng SQ, Cheng Y. PMID: 23132059.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. A method for integrative structure determination of protein-protein complexes. Bioinformatics. 2012 Dec 15; 28(24):3282-9. Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A. PMID: 23093611; PMCID: PMC3519461.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    58. Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils. Biomacromolecules. 2012 Nov 12; 13(11):3494-502. Martinez-Avila O, Wu S, Kim SJ, Cheng Y, Khan F, Samudrala R, Sali A, Horst JA, Habelitz S. PMID: 22974364; PMCID: PMC3496023.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    59. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. PMID: 22483106; PMCID: PMC3322386.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    60. Visualizing proteins and macromolecular complexes by negative stain EM: from grid preparation to image acquisition. J Vis Exp. 2011 Dec 22; (58). Booth DS, Avila-Sakar A, Cheng Y. PMID: 22215030; PMCID: PMC3369646.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    61. Self-assembly of amelogenin proteins at the water-oil interface. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:75-82. Martinez-Avila OM, Wu S, Cheng Y, Lee R, Khan F, Habelitz S. PMID: 22243231; PMCID: PMC6339812.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    62. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26. Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. PMID: 21489994; PMCID: PMC3121472.
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    63. A distributed multi-GPU system for high speed electron microscopic tomographic reconstruction. Ultramicroscopy. 2011 Jul; 111(8):1137-43. Zheng SQ, Branlund E, Kesthelyi B, Braunfeld MB, Cheng Y, Sedat JW, Agard DA. PMID: 21741915; PMCID: PMC3190582.
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    64. Self-aligning amelogenin nanoribbons in oil-water system. J Struct Biol. 2011 Apr; 174(1):203-12. He X, Wu S, Martinez-Avila O, Cheng Y, Habelitz S. PMID: 21134461; PMCID: PMC3204882.
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    65. Structure characterization of the 26S proteasome. Biochim Biophys Acta. 2011 Feb; 1809(2):67-79. Kim HM, Yu Y, Cheng Y. PMID: 20800708; PMCID: PMC3010250.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    66. HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12481-6. Daugherty MD, Booth DS, Jayaraman B, Cheng Y, Frankel AD. PMID: 20616058; PMCID: PMC2906596.
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    67. GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors. J Struct Biol. 2010 Dec; 172(3):407-12. Li X, Grigorieff N, Cheng Y. PMID: 20558298; PMCID: PMC2964447.
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    68. Collecting electron crystallographic data of two-dimensional protein crystals. Methods Enzymol. 2010; 481:251-82. Hite RK, Schenk AD, Li Z, Cheng Y, Walz T. PMID: 20887861.
      View in: PubMed   Mentions: 6     Fields:    
    69. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic. 2010 Jan; 11(1):110-22. Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM. PMID: 19912576; PMCID: PMC2796297.
      View in: PubMed   Mentions: 337     Fields:    Translation:HumansCells
    70. The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature. 2009 Dec 24; 462(7276):1016-21. Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ. PMID: 20033039; PMCID: PMC2869534.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    71. Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J. 2010 Feb 03; 29(3):692-702. Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y. PMID: 20019667; PMCID: PMC2830694.
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    72. Evaluation of imaging plates as recording medium for images of negatively stained single particles and electron diffraction patterns of two-dimensional crystals. J Electron Microsc (Tokyo). 2010; 59(1):53-63. Li Z, Hite RK, Cheng Y, Walz T. PMID: 19643814; PMCID: PMC3156676.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    73. Toward an atomic model of the 26S proteasome. Curr Opin Struct Biol. 2009 Apr; 19(2):203-8. Cheng Y. PMID: 19286367; PMCID: PMC2743420.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    74. A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis. Biochim Biophys Acta. 2009 May; 1793(5):772-80. Kim HZ, Jung K, Kim HM, Cheng Y, Koh GY. PMID: 19339208.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    75. The advent of near-atomic resolution in single-particle electron microscopy. Annu Rev Biochem. 2009; 78:723-42. Cheng Y, Walz T. PMID: 19489732.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    76. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell. 2008 May 09; 30(3):360-8. Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y. PMID: 18471981; PMCID: PMC4141531.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    77. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3739-44. Frey G, Peng H, Rits-Volloch S, Morelli M, Cheng Y, Chen B. PMID: 18322015; PMCID: PMC2268799.
      View in: PubMed   Mentions: 169     Fields:    Translation:Cells
    78. In vitro self-assembly of tailorable nanotubes from a simple protein building block. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3733-8. Ballister ER, Lai AH, Zuckermann RN, Cheng Y, Mougous JD. PMID: 18310321; PMCID: PMC2268831.
      View in: PubMed   Mentions: 118     Fields:    Translation:Cells
    79. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell. 2007 Dec 14; 28(5):871-85. Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T. PMID: 18082611; PMCID: PMC2197158.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    80. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20. J Mol Biol. 2008 Feb 15; 376(2):380-92. Gonen T, Hite RK, Cheng Y, Petre BM, Kistler J, Walz T. PMID: 18166196.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    81. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell. 2007 Sep 07; 27(5):731-44. Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL. PMID: 17803938; PMCID: PMC2083707.
      View in: PubMed   Mentions: 313     Fields:    Translation:AnimalsCells
    82. Reconstructing the endocytotic machinery. Methods Cell Biol. 2007; 79:463-87. Cheng Y, Walz T. PMID: 17327169.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    83. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9. Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T. PMID: 17095010; PMCID: PMC1839968.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    84. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity. 2006 Oct; 25(4):583-94. Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA. PMID: 17045822.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansCells
    85. Electron tomography of swollen rigor fibers of insect flight muscle reveals a short and variably angled S2 domain. J Mol Biol. 2006 Sep 29; 362(4):844-60. Liu J, Wu S, Reedy MC, Winkler H, Lucaveche C, Cheng Y, Reedy MK, Taylor KA. PMID: 16949613.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    86. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. PMID: 16908193; PMCID: PMC2910098.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    87. Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins. Biol Chem. 2006 Feb; 387(2):179-87. Nakagawa T, Cheng Y, Sheng M, Walz T. PMID: 16497150.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    88. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell. 2005 Dec 09; 20(5):687-98. Smith DM, Kafri G, Cheng Y, Ng D, Walz T, Goldberg AL. PMID: 16337593.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    89. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 01; 438(7068):633-8. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T. PMID: 16319884; PMCID: PMC1350984.
      View in: PubMed   Mentions: 333     Fields:    Translation:AnimalsCells
    90. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 03; 355(5):1048-65. Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T. PMID: 16343539.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    91. Single particle reconstruction of the human apo-transferrin-transferrin receptor complex. J Struct Biol. 2005 Dec; 152(3):204-10. Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. PMID: 16343946.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    92. Structure and different conformational states of native AMPA receptor complexes. Nature. 2005 Feb 03; 433(7025):545-9. Nakagawa T, Cheng Y, Ramm E, Sheng M, Walz T. PMID: 15690046.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    93. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. PMID: 15502812.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    94. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. PMID: 15502813.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    95. Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol. 2004 Sep 24; 342(4):1337-45. Gonen T, Cheng Y, Kistler J, Walz T. PMID: 15351655.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    96. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13; 429(6988):193-7. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. PMID: 15141214.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    97. A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol. 2004 May; 78(9):4508-16. Chen B, Cheng Y, Calder L, Harrison SC, Reinherz EL, Skehel JJ, Wiley DC. PMID: 15078931; PMCID: PMC387710.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    98. Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online. 2004; 6:23-34. Ohi M, Li Y, Cheng Y, Walz T. PMID: 15103397; PMCID: PMC389902.
      View in: PubMed   Mentions: 433  
    99. Structure of the human transferrin receptor-transferrin complex. Cell. 2004 Feb 20; 116(4):565-76. Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. PMID: 14980223.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    100. The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell. 2003 Nov; 12(5):1113-23. Toth EA, Li Y, Sawaya MR, Cheng Y, Ellenberger T. PMID: 14636571.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    101. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10704-9. Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T. PMID: 11535824; PMCID: PMC58530.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    102. The three-dimensional map of microsomal glutathione transferase 1 at 6 A resolution. EMBO J. 2000 Dec 01; 19(23):6311-6. Schmidt-Krey I, Mitsuoka K, Hirai T, Murata K, Cheng Y, Fujiyoshi Y, Morgenstern R, Hebert H. PMID: 11101503; PMCID: PMC305867.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    103. The projection structure of the membrane protein microsomal glutathione transferase at 3 A resolution as determined from two-dimensional hexagonal crystals. J Mol Biol. 1999 Apr 30; 288(2):243-53. Schmidt-Krey I, Murata K, Hirai T, Mitsuoka K, Cheng Y, Morgenstern R, Fujiyoshi Y, Hebert H. PMID: 10329140.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    104. Influence of various nucleotides on the in situ crystallization of Ca2+-ATPase. Biochim Biophys Acta. 1999 Jan 08; 1415(2):361-8. Hiroaki Y, Mitsuoka K, Cheng Y, Hiroaki H, Fujiyoshi Y. PMID: 9889398.
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    105. Characterization of the low magnification performance of a Philips CM300-FEG. Ultramicroscopy. 1998 Sep; 74(4):209-20. Cheng Y, Taylor KA. PMID: 9809458.
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    106. The use of electron tomography for structural analysis of disordered protein arrays. J Struct Biol. 1997 Dec; 120(3):372-86. Taylor KA, Tang J, Cheng Y, Winkler H. PMID: 9441940.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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