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Ryan Corces, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
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ORCID ORCID Icon0000-0001-7465-7652 Additional info
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    Princeton University, Princeton, NJAB06/2008Molecular Biology
    Stanford University, Stanford, CAPhD10/2015Cancer Biology
    Stanford University, Stanford, CAPostDoc06/2020Epigenetics, Neurobiology

    Collapse Overview 
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    The Corces lab melds epigenomics, computational biology, large-scale screens, and single-cell technologies to study neurodegeneration. We make heavy use of primary patient tissue to form hypotheses that can be tested in cellular and organismal model systems. Our long-term research interest is to use insights from the epigenome to inform our understanding of neurological disease with the goal of identifying novel avenues for therapeutic intervention. More specifically, we are interested in how the genome and epigenome intersect and how inherited genetic variation interfaces with lived experiences and environmental factors to produce durable and functional epigenetic alterations that lead to Alzheimer’s and Parkinson’s disease.

    Alzheimer’s disease (AD) and Parkinson’s disease (PD) both manifest as devastating age-related progressive neurodegeneration. This neurodegeneration and the concomitant loss of cognitive function plagues more than 44 million individuals worldwide for AD and more than 10 million individuals worldwide for PD. Our understanding of the molecular pathogenesis of these diseases remains incomplete and no therapies exist to prevent, stop, or cure the associated neurodegeneration. This marks one of the greatest unmet clinical needs of our time and a looming global public health crisis. At the most basic level, neurodegenerative diseases such as AD and PD result from the wrong genes being expressed in the wrong ways at the wrong times. Moreover, these are diseases of age with most patients manifesting symptoms after age 70. This age-associated onset of symptoms indicates that in addition to the known genetic causes of neurodegeneration, there are also epigenetic underpinnings to these diseases. This leads to the hypothesis that understanding the epigenome in AD and PD has the potential to provide key insights that inform the development of novel therapies.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-cell mutational profiling enhances the clinical evaluation of AML MRD. Blood Adv. 2020 03 10; 4(5):943-952. Ediriwickrema A, Aleshin A, Reiter JG, Corces MR, Köhnke T, Stafford M, Liedtke M, Medeiros BC, Majeti R. PMID: 32150611.
      View in: PubMed   Mentions: 1     Fields:    
    2. Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia. Nat Biotechnol. 2019 12; 37(12):1458-1465. Granja JM, Klemm S, McGinnis LM, Kathiria AS, Mezger A, Corces MR, Parks B, Gars E, Liedtke M, Zheng GXY, Chang HY, Majeti R, Greenleaf WJ. PMID: 31792411.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    3. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 11; 575(7784):699-703. Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. PMID: 31748743.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Nat Biotechnol. 2019 08; 37(8):925-936. Satpathy AT, Granja JM, Yost KE, Qi Y, Meschi F, McDermott GP, Olsen BN, Mumbach MR, Pierce SE, Corces MR, Shah P, Bell JC, Jhutty D, Nemec CM, Wang J, Wang L, Yin Y, Giresi PG, Chang ALS, Zheng GXY, Greenleaf WJ, Chang HY. PMID: 31375813.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    5. HiChIRP reveals RNA-associated chromosome conformation. Nat Methods. 2019 06; 16(6):489-492. Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ, Chang HY. PMID: 31133759.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA. Elife. 2019 04 09; 8. Xu J, Nuno K, Litzenburger UM, Qi Y, Corces MR, Majeti R, Chang HY. PMID: 30958261.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. The chromatin accessibility landscape of primary human cancers. Science. 2018 10 26; 362(6413). Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C, Greenleaf WJ, Chang HY. PMID: 30361341.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    8. Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation. Cell. 2018 05 31; 173(6):1535-1548.e16. Buenrostro JD, Corces MR, Lareau CA, Wu B, Schep AN, Aryee MJ, Majeti R, Chang HY, Greenleaf WJ. PMID: 29706549.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    9. Transcript-indexed ATAC-seq for precision immune profiling. Nat Med. 2018 05; 24(5):580-590. Satpathy AT, Saligrama N, Buenrostro JD, Wei Y, Wu B, Rubin AJ, Granja JM, Lareau CA, Li R, Qi Y, Parker KR, Mumbach MR, Serratelli WS, Gennert DG, Schep AN, Corces MR, Khodadoust MS, Kim YH, Khavari PA, Greenleaf WJ, Davis MM, Chang HY. PMID: 29686426.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    10. Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia. Front Oncol. 2017; 7:263. Corces MR, Chang HY, Majeti R. PMID: 29164062.
      View in: PubMed   Mentions:
    11. Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons. Cell Rep. 2017 Sep 26; 20(13):3236-3247. Wapinski OL, Lee QY, Chen AC, Li R, Corces MR, Ang CE, Treutlein B, Xiang C, Baubet V, Suchy FP, Sankar V, Sim S, Quake SR, Dahmane N, Wernig M, Chang HY. PMID: 28954238.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Nat Genet. 2017 Nov; 49(11):1602-1612. Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY. PMID: 28945252.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    13. An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods. 2017 Oct; 14(10):959-962. Corces MR, Trevino AE, Hamilton EG, Greenside PG, Sinnott-Armstrong NA, Vesuna S, Satpathy AT, Rubin AJ, Montine KS, Wu B, Kathiria A, Cho SW, Mumbach MR, Carter AC, Kasowski M, Orloff LA, Risca VI, Kundaje A, Khavari PA, Montine TJ, Greenleaf WJ, Chang HY. PMID: 28846090.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    14. Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARa Dependency Targetable by SY-1425, a Potent and Selective RARa Agonist. Cancer Discov. 2017 10; 7(10):1136-1153. McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R. PMID: 28729405.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    15. Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Cell Stem Cell. 2017 03 02; 20(3):329-344.e7. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. PMID: 28089908.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    16. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution. Nat Genet. 2016 10; 48(10):1193-203. Corces MR, Buenrostro JD, Wu B, Greenside PG, Chan SM, Koenig JL, Snyder MP, Pritchard JK, Kundaje A, Greenleaf WJ, Majeti R, Chang HY. PMID: 27526324.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    17. A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells. Nat Med. 2016 07; 22(7):812-21. Reinisch A, Thomas D, Corces MR, Zhang X, Gratzinger D, Hong WJ, Schallmoser K, Strunk D, Majeti R. PMID: 27213817.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    18. The three-dimensional cancer genome. Curr Opin Genet Dev. 2016 02; 36:1-7. Corces MR, Corces VG. PMID: 26855137.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. Cell Stem Cell. 2015 Dec 03; 17(6):675-688. Mazumdar C, Shen Y, Xavy S, Zhao F, Reinisch A, Li R, Corces MR, Flynn RA, Buenrostro JD, Chan SM, Thomas D, Koenig JL, Hong WJ, Chang HY, Majeti R. PMID: 26607380.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    20. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat Med. 2015 Feb; 21(2):178-84. Chan SM, Thomas D, Corces-Zimmerman MR, Xavy S, Rastogi S, Hong WJ, Zhao F, Medeiros BC, Tyvoll DA, Majeti R. PMID: 25599133.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    21. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition. Blood. 2015 Jan 08; 125(2):316-26. Sinha S, Thomas D, Yu L, Gentles AJ, Jung N, Corces-Zimmerman MR, Chan SM, Reinisch A, Feinberg AP, Dill DL, Majeti R. PMID: 25398938.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia. 2014 Dec; 28(12):2276-82. Corces-Zimmerman MR, Majeti R. PMID: 25005245.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    23. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2548-53. Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R. PMID: 24550281.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansCells
    24. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med. 2012 Aug 29; 4(149):149ra118. Jan M, Snyder TM, Corces-Zimmerman MR, Vyas P, Weissman IL, Quake SR, Majeti R. PMID: 22932223.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimalsCells
    25. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature. 2011 Apr 07; 472(7341):120-4. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta RA, Wysocka J, Lei M, Dekker J, Helms JA, Chang HY. PMID: 21423168.
      View in: PubMed   Mentions: 734     Fields:    Translation:HumansAnimalsCells
    26. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol. 2010 May 18; 8(5):e1000372. Kauffman AL, Ashraf JM, Corces-Zimmerman MR, Landis JN, Murphy CT. PMID: 20502519.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
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