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Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis. J Med Chem. 2022 02 24; 65(4):3539-3562.
Park SJ, Yeon SK, Kim Y, Kim HJ, Kim S, Kim J, Choi JW, Kim B, Lee EH, Kim R, Seo SH, Lee J, Kim JW, Lee HY, Hwang H, Bahn YS, Cheong E, Park JH, Park KD. PMID: 35077170.
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4 Fields:
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HumansAnimalsCells
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Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection. J Med Chem. 2021 11 11; 64(21):15912-15935.
Choi JW, Lee KT, Kim S, Lee YR, Kim HJ, Seo KJ, Lee MH, Yeon SK, Jang BK, Park SJ, Kim HJ, Park JH, Kim D, Lee DG, Cheong E, Lee JS, Bahn YS, Park KD. PMID: 34662122.
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4 Fields:
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HumansAnimalsCells
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Modular Approaches to Lankacidin Antibiotics. J Am Chem Soc. 2020 09 02; 142(35):15116-15126.
Cai L, Yao Y, Yeon SK, Seiple IB. PMID: 32786797; PMCID: PMC8193914.
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8 Fields:
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Cells
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Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease. Neuronal Signal. 2019 06; 3(2):NS20190001.
White KA, Cain JT, Magee H, Yeon SK, Park KD, Khanna R, Weimer JM. PMID: 32269836; PMCID: PMC7104323.
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Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease. Sci Adv. 2019 03; 5(3):eaav0316.
Park JH, Ju YH, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Kim J, Cho SJ, Cho S, Lee C, Hwang SY, Kim SW, Oh SJ, Cho J, Pae AN, Lee CJ, Park KD. PMID: 30906861; PMCID: PMC6426469.
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68 Fields:
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CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. 2017 Dec; 158(12):2301-2319.
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R. PMID: 28809766; PMCID: PMC6362827.
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40 Fields:
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AnimalsCells
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Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy. Bioorg Med Chem. 2018 01 01; 26(1):232-244.
Yeon SK, Choi JW, Park JH, Lee YR, Kim HJ, Shin SJ, Jang BK, Kim S, Bahn YS, Han G, Lee YS, Pae AN, Park KD. PMID: 29198609.
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10 Fields:
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HumansAnimalsCells
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CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation. Mol Neurobiol. 2018 May; 55(5):4403-4416.
Moutal A, Villa LS, Yeon SK, Householder KT, Park KD, Sirianni RW, Khanna R. PMID: 28660485; PMCID: PMC5745298.
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20 Fields:
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(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. 2016 07; 157(7):1448-1463.
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R. PMID: 26967696; PMCID: PMC4936788.
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34 Fields:
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AnimalsCells
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Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica. ChemMedChem. 2016 Feb 17; 11(4):377-81.
Ju EJ, Yeon SK, Park JH, Cheon SY, Choi JW, Ha T, Jang BK, Kim S, Kang YG, Hwang H, Cho SJ, Cheong E, Bahn YS, Pae AN, Kim SM, Park KD. PMID: 26804736.
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Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors. Bioorg Med Chem. 2015 Oct 01; 23(19):6486-96.
Choi JW, Jang BK, Cho NC, Park JH, Yeon SK, Ju EJ, Lee YS, Han G, Pae AN, Kim DJ, Park KD. PMID: 26337020.
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21 Fields:
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HumansCells
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(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5. Mol Neurobiol. 2016 Apr; 53(3):1959-1976.
Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R. PMID: 25846820.
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37 Fields:
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AnimalsCells
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Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy. J Med Chem. 2014 Feb 27; 57(4):1473-87.
Woo SY, Kim JH, Moon MK, Han SH, Yeon SK, Choi JW, Jang BK, Song HJ, Kang YG, Kim JW, Lee J, Kim DJ, Hwang O, Park KD. PMID: 24467268.
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41 Fields:
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HumansAnimalsCells