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Ian Seiple, PhD

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-502-3623
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    Collapse Biography 
    Collapse Education and Training
    UC BerkeleyBS2006Chemistry
    The Scripps Research InstitutePh.D.2011Chemistry
    Harvard UniversityPostdoctoral2015Chemistry and Chemical Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Platforms for the Synthesis of Bacterial Protein Synthesis Inhibitors
    NIH/NIGMS R35GM128656Aug 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Preparation of a Solid-Phase Polyketide Synthase Mimic
    NIH/NIGMS F32GM099233Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Modular Approaches to Lankacidin Antibiotics. J Am Chem Soc. 2020 Aug 19. Cai L, Yao Y, Yeon SK, Seiple IB. PMID: 32786797.
      View in: PubMed   Mentions:    Fields:    
    2. Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes. Angew Chem Int Ed Engl. 2019 12 19; 58(52):18839-18843. Liu J, Cai L, Sun W, Cheng R, Wang N, Jin L, Rozovsky S, Seiple IB, Wang L. PMID: 31644827.
      View in: PubMed   Mentions: 1     Fields:    
    3. A concise route to virginiamycin M2. Tetrahedron. 2019 Jun 14; 75(24):3309-3318. Li Q, Seiple IB. PMID: 32764837.
      View in: PubMed   Mentions:    Fields:    
    4. Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B. Angew Chem Int Ed Engl. 2018 10 08; 57(41):13551-13554. Yao Y, Cai L, Seiple IB. PMID: 30133094.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Modular, Scalable Synthesis of Group A Streptogramin Antibiotics. J Am Chem Soc. 2017 09 27; 139(38):13304-13307. Li Q, Seiple IB. PMID: 28902996.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    6. A platform for the discovery of new macrolide antibiotics. Nature. 2016 05 19; 533(7603):338-45. Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, Kitamura Y, Zhou X, Condakes ML, Szczypinski FT, Green WD, Myers AG. PMID: 27193679.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    7. Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxybutan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics. Synlett. 2015; 1(27):57-60. Seiple, I. B.; Hog, D. T.; Myers, A. G.
    8. The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8840-69. Wright PM, Seiple IB, Myers AG. PMID: 24990531.
      View in: PubMed   Mentions: 39     Fields:    
    9. Stereocontrolled synthesis of syn-ß-Hydroxy-a-amino acids by direct aldolization of pseudoephenamine glycinamide. Angew Chem Int Ed Engl. 2014 Apr 25; 53(18):4642-7. Seiple IB, Mercer JA, Sussman RJ, Zhang Z, Myers AG. PMID: 24692320.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome. J Nat Prod. 2012 May 25; 75(5):980-5. Lansdell TA, Hewlett NM, Skoumbourdis AP, Fodor MD, Seiple IB, Su S, Baran PS, Feldman KS, Tepe JJ. PMID: 22591513.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Configurational analysis of tetracyclic dimeric pyrrole-imidazole alkaloids using a floating chirality approach. J Nat Prod. 2012 Feb 24; 75(2):127-30. Köck M, Schmidt G, Seiple IB, Baran PS. PMID: 22332969.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc. 2011 Sep 21; 133(37):14710-26. Seiple IB, Su S, Young IS, Nakamura A, Yamaguchi J, Jørgensen L, Rodriguez RA, O'Malley DP, Gaich T, Köck M, Baran PS. PMID: 21861522.
      View in: PubMed   Mentions: 23     Fields:    
    13. Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14411-5. Ji Y, Brueckl T, Baxter RD, Fujiwara Y, Seiple IB, Su S, Blackmond DG, Baran PS. PMID: 21844378.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    14. Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc. 2011 Mar 16; 133(10):3292-5. Fujiwara Y, Domingo V, Seiple IB, Gianatassio R, Del Bel M, Baran PS. PMID: 21341741.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    15. Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc. 2010 Sep 29; 132(38):13194-6. Seiple IB, Su S, Rodriguez RA, Gianatassio R, Fujiwara Y, Sobel AL, Baran PS. PMID: 20812741.
      View in: PubMed   Mentions: 46     Fields:    
    16. Total synthesis of palau'amine. Angew Chem Int Ed Engl. 2010 Feb 01; 49(6):1095-8. Seiple IB, Su S, Young IS, Lewis CA, Yamaguchi J, Baran PS. PMID: 20041464.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    17. Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc. 2008 Dec 10; 130(49):16490-1. Su S, Seiple IB, Young IS, Baran PS. PMID: 19049446.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    18. Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl. 2008; 47(19):3578-80. Yamaguchi J, Seiple IB, Young IS, O'Malley DP, Maue M, Baran PS. PMID: 18357598.
      View in: PubMed   Mentions: 24     Fields:    
    19. Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl. 2008; 47(19):3581-3. O'Malley DP, Yamaguchi J, Young IS, Seiple IB, Baran PS. PMID: 18357612.
      View in: PubMed   Mentions: 27     Fields:    
    20. The pursuit of palau'amine. Angew Chem Int Ed Engl. 2007; 46(35):6586-94. Köck M, Grube A, Seiple IB, Baran PS. PMID: 17724780.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    21. Synthesis of taiwaniaquinoids via Nazarov triflation. J Am Chem Soc. 2006 Aug 30; 128(34):11022-3. Liang G, Xu Y, Seiple IB, Trauner D. PMID: 16925409.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    22. Stereoselective syntheses of the bioactive polypropionates aureothin, N-acetylaureothamine, and aureonitrile. Org Lett. 2005 Jul 07; 7(14):2837-9. Liang G, Seiple IB, Trauner D. PMID: 15987149.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
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