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Alan Verkman, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-8530
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    Collapse Biography 
    Collapse Education and Training
    M.I.T.S.B., S.B.Physics, Biology
    Harvard UniversityM.A., Ph.D.Physics
    Harvard Medical School / HSTM.D.
    Brigham & Womens HospitalResidency Medicine
    University of California, San FranciscoFellowship Nephrology

    Collapse Research 
    Collapse Research Activities and Funding
    Urea transport inhibitors as a new class of diuretics
    NIH/NIDDK R01DK101373Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    CFTR inhibitors for therapy of polycystic kidney disease
    NIH/NIDDK RC1DK086125Sep 25, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Novel Small-Molecule Therapies for CF
    NIH/NIDDK P30DK072517Sep 15, 2005 - May 31, 2020
    Role: Principal Investigator
    Role of airway submucosal glands in CF lung disease
    NIH/NHLBI R01HL073856Sep 1, 2003 - Aug 31, 2013
    Role: Principal Investigator
    Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New Therapies
    NIH/NEI R01EY013574Jul 1, 2001 - Apr 30, 2023
    Role: Principal Investigator
    Physiology and Molecular Biology of Lung Water Transport
    NIH/NHLBI R01HL059198Sep 1, 1998 - Jul 31, 2009
    Role: Principal Investigator
    ALTERATIONS IN AIRWAY SURFACE LIQUID IN CYSTIC FIBROSIS
    NIH P50HL060288Sep 1, 1998 - Aug 31, 2003
    Role: Co-Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH/NIBIB R37EB000415Jul 1, 1997 - Mar 31, 2017
    Role: Principal Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH/NIBIB R01EB000415Jul 1, 1997 - Mar 31, 2007
    Role: Principal Investigator
    MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    NIH/FIC R03TW000704Sep 1, 1996 - Aug 31, 2000
    Role: Principal Investigator
    APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    NIH/NIDDK R01DK043840Feb 1, 1993 - Jan 31, 2002
    Role: Principal Investigator
    DEVELOPMENT OF CHLORIDE-SENSITIVE FLUORESCENT INDICATORS
    NIH/NIDDK R01DK039354Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    Mechanisms of water transport in renal epithelia
    NIH/NIDDK R01DK035124Jan 1, 1986 - Jun 30, 2015
    Role: Principal Investigator
    MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    NIH/NIDDK R37DK035124Jan 1, 1986 - May 31, 2010
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CF pathogenesis mechanisms and therapies
    Cystic Fibrosis Foundation
    Role: PI
    Neuromyelitis Optica: Disease Mechanisms & New Therapies
    Guthy-Jackson Charitable Foundation
    Role: PI

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman A. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 Apr 12; 61(7):3209-3217. PMID: 29589443.
      View in: PubMed
    2. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman A. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov. 2018 Mar 01; 2472555218763310. PMID: 29533733.
      View in: PubMed
    3. Verkman A, Yao X, Smith AJ. The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. J Cell Mol Med. 2018 Mar; 22(3):2039-2040. PMID: 29363875.
      View in: PubMed
    4. Smith AJ, Verkman A. The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB J. 2018 Feb; 32(2):543-551. PMID: 29101220.
      View in: PubMed
    5. Verkman A, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert Opin Ther Targets. 2017 12; 21(12):1161-1170. PMID: 29072508.
      View in: PubMed
    6. Felix CM, Lee S, Levin MH, Verkman A. Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4506-4513. PMID: 28873176.
      View in: PubMed
    7. Smith AJ, Yao X, Dix JA, Jin BJ, Verkman A. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. Elife. 2017 Aug 21; 6. PMID: 28826498.
      View in: PubMed
    8. Yao X, Verkman A. Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 07 27; 5(1):57. PMID: 28750658.
      View in: PubMed
    9. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. Mechanisms of Autoantibody-Induced Pathology. Front Immunol. 2017; 8:603. PMID: 28620373.
      View in: PubMed
    10. Tradtrantip L, Yao X, Su T, Smith AJ, Verkman A. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta Neuropathol. 2017 Jul; 134(1):35-44. PMID: 28567523.
      View in: PubMed
    11. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman A, Anderson MO. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 Jun 08; 60(11):4626-4635. PMID: 28493701.
      View in: PubMed
    12. Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman A, Mangiatordi GF, Nicolotti O. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochim Biophys Acta. 2017 08; 1859(8):1326-1334. PMID: 28477975.
      View in: PubMed
    13. Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman A, Yang B. Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochim Biophys Acta. 2017 Jun; 1863(6):1231-1241. PMID: 28344130.
      View in: PubMed
    14. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman A, Kurth MJ. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 Mar 23; 60(6):2401-2410. PMID: 28230981.
      View in: PubMed
    15. Jin BJ, Verkman A. Microfluidic platform for rapid measurement of transepithelial water transport. Lab Chip. 2017 02 28; 17(5):887-895. PMID: 28184395.
      View in: PubMed
    16. Yao X, Verkman A. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 Feb 17; 5(1):15. PMID: 28212662.
      View in: PubMed
    17. Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman A. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. J Med Chem. 2017 Feb 09; 60(3):1210-1218. PMID: 28099811.
      View in: PubMed
    18. Thiagarajah JR, Chang J, Goettel JA, Verkman A, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. PMID: 28049834.
      View in: PubMed
    19. Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman A. Aquaporin-Targeted Therapeutics: State-of-the-Field. Adv Exp Med Biol. 2017; 969:239-250. PMID: 28258578.
      View in: PubMed
    20. Verkman A, Tradtrantip L, Smith AJ, Yao X. Aquaporin Water Channels and Hydrocephalus. Pediatr Neurosurg. 2017; 52(6):409-416. PMID: 27978530.
      View in: PubMed
    21. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman A, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14781-14786. PMID: 27940915.
      View in: PubMed
    22. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman A. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. J Biol Chem. 2017 01 20; 292(3):771-785. PMID: 27895116.
      View in: PubMed
    23. Jin BJ, Smith AJ, Verkman A. Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. J Gen Physiol. 2016 Dec; 148(6):489-501. PMID: 27836940.
      View in: PubMed
    24. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman A. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 02; 31(2):751-760. PMID: 27871064.
      View in: PubMed
    25. Felix CM, Levin MH, Verkman A. Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. J Neuroinflammation. 2016 10 20; 13(1):275. PMID: 27765056.
      View in: PubMed
    26. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman A. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4. PMID: 27815136.
      View in: PubMed
    27. Reed GD, von Morze C, Verkman A, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. PMID: 27570835.
      View in: PubMed
    28. Tradtrantip L, Verkman A. Aquaporin gene therapy for disorders of cholestasis? Hepatology. 2016 08; 64(2):344-6. PMID: 27115396.
      View in: PubMed
    29. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman A, Narumiya S, Mishima M, Chin K. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Sci Rep. 2016 05 11; 6:25781. PMID: 27165276.
      View in: PubMed
    30. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman A. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714. PMID: 27153921.
      View in: PubMed
    31. Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman A, Anderson MO. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. J Enzyme Inhib Med Chem. 2016 Dec; 31(6):1362-8. PMID: 26796863; PMCID: PMC4958041 [Available on 07/22/17].
    32. Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. J Cereb Blood Flow Metab. 2017 Jan; 37(1):277-290. PMID: 26767580.
      View in: PubMed
    33. Smith AJ, Verkman A. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophys J. 2015 Dec 15; 109(12):2511-22. PMID: 26682810; PMCID: PMC4699884 [Available on 12/15/16].
    34. Verkman A, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. J Cyst Fibros. 2015 Nov; 14(6):700-5. PMID: 26474804; PMCID: PMC4786369.
    35. Jo AO, Ryskamp DA, Phuong TT, Verkman A, Yarishkin O, MacAulay N, Križaj D. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci. 2015 Sep 30; 35(39):13525-37. PMID: 26424896; PMCID: PMC4588615.
    36. Jin BJ, Esteva-Font C, Verkman A. Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab Chip. 2015 Aug 21; 15(16):3380-90. PMID: 26159099; PMCID: PMC4706553.
    37. Thiagarajah JR, Donowitz M, Verkman A. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):446-57. PMID: 26122478; PMCID: PMC4786374.
    38. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman A. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. J Neurotrauma. 2015 Oct 01; 32(19):1458-64. PMID: 25790314; PMCID: PMC4589265 [Available on 10/01/16].
    39. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman A. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015 Aug; 88(2):311-20. PMID: 25993324.
      View in: PubMed
    40. Smith AJ, Jin BJ, Verkman A. Muddying the water in brain edema? Trends Neurosci. 2015 Jun; 38(6):331-2. PMID: 25980601; PMCID: PMC4739497.
    41. Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman A, Bennett JL. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. J Biol Chem. 2015 May 08; 290(19):12123-34. PMID: 25792738; PMCID: PMC4424347.
    42. Esteva-Font C, Anderson MO, Verkman A. Urea transporter proteins as targets for small-molecule diuretics. Nat Rev Nephrol. 2015 Feb; 11(2):113-23. PMID: 25488859; PMCID: PMC4743986.
    43. Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman A, Bollen AW, Ralph JW. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle Nerve. 2014 Nov; 50(5):859-62. PMID: 24862586; PMCID: PMC4306419.
    44. Papadopoulos MC, Bennett JL, Verkman A. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nat Rev Neurol. 2014 Sep; 10(9):493-506. PMID: 25112508; PMCID: PMC4229040.
    45. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman A, Lukacs GL. Some gating potentiators, including VX-770, diminish ?F508-CFTR functional expression. Sci Transl Med. 2014 Jul 23; 6(246):246ra97. PMID: 25101887; PMCID: PMC4467693.
    46. Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman A. Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids. Biomicrofluidics. 2014 Mar; 8(2):024106. PMID: 24738013; PMCID: PMC3976466.
    47. Verkman A, Anderson MO, Papadopoulos MC. Aquaporins: important but elusive drug targets. Nat Rev Drug Discov. 2014 Apr; 13(4):259-77. PMID: 24625825; PMCID: PMC4067137.
    48. Tradtrantip L, Ko EA, Verkman A. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2674. PMID: 24551253; PMCID: PMC3923670.
    49. Smith AJ, Jin BJ, Ratelade J, Verkman A. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. J Cell Biol. 2014 Feb 17; 204(4):559-73. PMID: 24515349; PMCID: PMC3926963.
    50. Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman A. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. J Neuroinflammation. 2014 Jan 27; 11:16. PMID: 24468108; PMCID: PMC3909205.
    51. Verkman A, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Small-molecule inhibitors of urea transporters. Subcell Biochem. 2014; 73:165-77. PMID: 25298345; PMCID: PMC4306426.
    52. Esteva-Font C, Jin BJ, Verkman A. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J. 2014 Mar; 28(3):1446-53. PMID: 24334548; PMCID: PMC3929666.
    53. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman A, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB J. 2014 Feb; 28(2):791-801. PMID: 24200884; PMCID: PMC3898646.
    54. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman A. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB J. 2014 Feb; 28(2):705-14. PMID: 24186965; PMCID: PMC3898642.
    55. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman A, Donowitz M. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clin Gastroenterol Hepatol. 2014 Jan; 12(1):27-31. PMID: 24184676; PMCID: PMC3926754.
    56. Jin BJ, Ko EA, Namkung W, Verkman A. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds. Lab Chip. 2013 Oct 07; 13(19):3862-7. PMID: 23907501; PMCID: PMC3904508.
    57. Rowe SM, Verkman A. Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harb Perspect Med. 2013 Jul 01; 3(7). PMID: 23818513; PMCID: PMC3685879.
    58. Jin BJ, Zhang H, Binder DK, Verkman A. Response to "When can AQP4 assist transporter-mediated K? uptake?". J Gen Physiol. 2013 Jul; 142(1):91-2. PMID: 23752331; PMCID: PMC3691444.
    59. Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman A, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Mechanism-based corrector combination restores ?F508-CFTR folding and function. Nat Chem Biol. 2013 Jul; 9(7):444-54. PMID: 23666117; PMCID: PMC3840170.
    60. Papadopoulos MC, Verkman A. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013 Apr; 14(4):265-77. PMID: 23481483; PMCID: PMC3732112.
    61. Verkman A. Aquaporins. Curr Biol. 2013 Jan 21; 23(2):R52-5. PMID: 23347934; PMCID: PMC3590904.
    62. Verkman A, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. CFTR inhibitors. Curr Pharm Des. 2013; 19(19):3529-41. PMID: 23331030; PMCID: PMC4012685.
    63. Valentine CD, Lukacs GL, Verkman A, Haggie PM. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. J Biol Chem. 2012 Dec 21; 287(52):43630-8. PMID: 23115232.
      View in: PubMed
    64. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman A, Inoue S, Miyachi Y. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med. 2012 Sep 24; 209(10):1743-52. PMID: 22927550; PMCID: PMC3457725.
    65. Verkman A. Aquaporins in clinical medicine. Annu Rev Med. 2012; 63:303-16. PMID: 22248325; PMCID: PMC3319404.
    66. Verkman A. Aquaporins at a glance. J Cell Sci. 2011 Jul 01; 124(Pt 13):2107-12. PMID: 21670197.
      View in: PubMed
    67. Verkman A, Ratelade J, Rossi A, Zhang H, Tradtrantip L. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta Pharmacol Sin. 2011 Jun; 32(6):702-10. PMID: 21552296; PMCID: PMC3601948.
    68. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman A, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci. 2011 Apr 27; 31(17):6392-7. PMID: 21525279; PMCID: PMC3107562.
    69. Carpenter RD, Verkman A. Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing. European J Org Chem. 2011 Mar 01; 2011(7):1242-1248. PMID: 23914138.
      View in: PubMed
    70. Nakahigashi K, Kabashima K, Ikoma A, Verkman A, Miyachi Y, Hara-Chikuma M. Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. J Invest Dermatol. 2011 Apr; 131(4):865-73. PMID: 21191421.
      View in: PubMed
    71. Kimura A, Hsu M, Seldin M, Verkman A, Scharfman HE, Binder DK. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010 Jun; 67(6):794-801. PMID: 20517941.
      View in: PubMed
    72. Verkman A. Aquaporins: translating bench research to human disease. J Exp Biol. 2009 Jun; 212(Pt 11):1707-15. PMID: 19448080; PMCID: PMC2683014.
    73. Crane JM, Verkman A. Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging. J Cell Sci. 2009 Mar 15; 122(Pt 6):813-21. PMID: 19240114; PMCID: PMC2714425.
    74. Verkman A. Knock-out models reveal new aquaporin functions. Handb Exp Pharmacol. 2009; (190):359-81. PMID: 19096787; PMCID: PMC3595129.
    75. Verkman A, Ruiz-Ederra J, Levin MH. Functions of aquaporins in the eye. Prog Retin Eye Res. 2008 Jul; 27(4):420-33. PMID: 18501660; PMCID: PMC3319433.
    76. Verkman A. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert Rev Mol Med. 2008 May 16; 10:e13. PMID: 18482462; PMCID: PMC3601943.
    77. Verkman A. Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Semin Nephrol. 2008 May; 28(3):217-26. PMID: 18519083; PMCID: PMC2692584.
    78. Verkman A, Hara-Chikuma M, Papadopoulos MC. Aquaporins--new players in cancer biology. J Mol Med (Berl). 2008 May; 86(5):523-9. PMID: 18311471; PMCID: PMC3590015.
    79. Verkman A, Galietta LJ. Chloride channels as drug targets. Nat Rev Drug Discov. 2009 Feb; 8(2):153-71. PMID: 19153558; PMCID: PMC3601949.
    80. Papadopoulos MC, Verkman A. Aquaporin-4 and brain edema. Pediatr Nephrol. 2007 Jun; 22(6):778-84. PMID: 17347837.
      View in: PubMed
    81. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman A, Davis PB. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L383-95. PMID: 16920886.
      View in: PubMed
    82. Binder DK, Yao X, Zador Z, Sick TJ, Verkman A, Manley GT. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia. 2006 Apr 15; 53(6):631-6. PMID: 16470808.
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    83. Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol. 2005 Sep; 25(17):7770-9. PMID: 16107722; PMCID: PMC1190286.
    84. Schulz BL, Sloane AJ, Robinson LJ, Sebastian LT, Glanville AR, Song Y, Verkman A, Harry JL, Packer NH, Karlsson NG. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. Biochem J. 2005 May 01; 387(Pt 3):911-9. PMID: 15563276; PMCID: PMC1135025.
    85. Verkman A. Drug discovery and epithelial physiology. Curr Opin Nephrol Hypertens. 2004 Sep; 13(5):563-8. PMID: 15300164.
      View in: PubMed
    86. Thiagarajah JR, Broadbent T, Hsieh E, Verkman A. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology. 2004 Feb; 126(2):511-9. PMID: 14762788.
      View in: PubMed
    87. Verkman A. Diffusion in cells measured by fluorescence recovery after photobleaching. Methods Enzymol. 2003; 360:635-48. PMID: 12622172.
      View in: PubMed
    88. Mann SE, Ricke EA, Yang BA, Verkman A, Taylor RN. Expression and localization of aquaporin 1 and 3 in human fetal membranes. Am J Obstet Gynecol. 2002 Oct; 187(4):902-7. PMID: 12388974.
      View in: PubMed
    89. Mennone A, Verkman A, Boyer JL. Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G739-46. PMID: 12181190.
      View in: PubMed
    90. Verkman A. Physiological importance of aquaporin water channels. Ann Med. 2002; 34(3):192-200. PMID: 12173689.
      View in: PubMed
    91. Verkman A. Solute and macromolecule diffusion in cellular aqueous compartments. Trends Biochem Sci. 2002 Jan; 27(1):27-33. PMID: 11796221.
      View in: PubMed
    92. Verkman A, Jayaraman S. Fluorescent indicator methods to assay functional CFTR expression in cells. Methods Mol Med. 2002; 70:187-96. PMID: 11917522.
      View in: PubMed
    93. Verkman A, Yang B. Aquaporin gene delivery to kidney. Kidney Int. 2002 Jan; 61(1 Suppl):S120-4. PMID: 11841625.
      View in: PubMed