Alan Verkman, MD, PhD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #1235A
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    M.I.T.S.B., S.B.Physics, Biology
    Harvard UniversityM.A., Ph.D.Physics
    Harvard Medical School / HSTM.D.
    Brigham & Womens HospitalResidency Medicine
    University of California, San FranciscoFellowship Nephrology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Urea transport inhibitors as a new class of diuretics
    NIH R01DK101373Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    CFTR inhibitors for therapy of polycystic kidney disease
    NIH RC1DK086125Sep 25, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Novel small-molecule therapies for CF
    NIH P30DK072517Aug 1, 2005 - May 31, 2023
    Role: Principal Investigator
    Role of airway submucosal glands in CF lung disease
    NIH R01HL073856Sep 1, 2003 - Aug 31, 2013
    Role: Principal Investigator
    Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New Therapies
    NIH R01EY013574Jul 1, 2001 - Apr 30, 2023
    Role: Principal Investigator
    Physiology and Molecular Biology of Lung Water Transport
    NIH R01HL059198Sep 1, 1998 - Jul 31, 2009
    Role: Principal Investigator
    NIH P50HL060288Sep 1, 1998 - Aug 31, 2003
    Role: Co-Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH R37EB000415Jul 1, 1997 - Mar 31, 2019
    Role: Principal Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH R01EB000415Jul 1, 1997 - Mar 31, 2007
    Role: Principal Investigator
    NIH R03TW000704Sep 1, 1996 - Aug 31, 2000
    Role: Principal Investigator
    NIH R01DK043840Feb 1, 1993 - Jan 31, 2002
    Role: Principal Investigator
    NIH R01DK039354Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    Mechanisms of water transport in renal epithelia
    NIH R01DK035124Jan 1, 1986 - Jun 30, 2017
    Role: Principal Investigator
    NIH R37DK035124Jan 1, 1986 - May 31, 2010
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CF pathogenesis mechanisms and therapies
    Cystic Fibrosis Foundation
    Role: PI
    Neuromyelitis Optica: Disease Mechanisms & New Therapies
    Guthy-Jackson Charitable Foundation
    Role: PI

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration. Ocul Surf. 2024 Jun 11; 34:30-37. Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O. PMID: 38871216.
      View in: PubMed   Mentions:    Fields:    
    2. Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria. RSC Med Chem. 2024 May 22; 15(5):1731-1736. Ahmadi M, de Souza Goncalves L, Verkman AS, Cil O, Anderson MO. PMID: 38784456; PMCID: PMC11110725.
      View in: PubMed   Mentions:
    3. Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs). Curr Ophthalmol Rep. 2024 Jun; 12(2):13-22. Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND. PMID: 38756824; PMCID: PMC11095972.
      View in: PubMed   Mentions:
    4. Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice. Fluids Barriers CNS. 2024 Jan 04; 21(1):1. Tong XJ, Akdemir G, Wadhwa M, Verkman AS, Smith AJ. PMID: 38178155; PMCID: PMC10768282.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Transgenic ferret models define pulmonary ionocyte diversity and function. Nature. 2023 Sep; 621(7980):857-867. Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, Dick DW, Wadas TJ, Joo NS, Wine JJ, Birket S, Fernandez CM, Leung HM, Tearney GJ, Verkman AS, Haggie PM, Scott K, Bartels D, Meyerholz DK, Rowe SM, Liu X, Yan Z, Haber AL, Sun X, Engelhardt JF. PMID: 37730992; PMCID: PMC10533402.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    6. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC Med Chem. 2023 Nov 15; 14(11):2342-2347. Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O. PMID: 37974969; PMCID: PMC10650448.
      View in: PubMed   Mentions:
    7. T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity. Proc Natl Acad Sci U S A. 2023 07 25; 120(30):e2306572120. Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS. PMID: 37463205; PMCID: PMC10372680.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 05; 249:115149. Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS. PMID: 36724632; PMCID: PMC10124120.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    9. Ocular Surface Ion Transport and Dry Eye Disease. Curr Ophthalmol Rep. 2022 Dec; 10(4):188-197. Lindgren ES, Cil O, Verkman AS, Pasricha ND. PMID: 38213468; PMCID: PMC10783585.
      View in: PubMed   Mentions:
    10. Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis. JCI Insight. 2022 07 08; 7(13). Cil O, Chu T, Lee S, Haggie PM, Verkman AS. PMID: 35608921; PMCID: PMC9310519.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    11. A simple method to generate human airway epithelial organoids with externally orientated apical membranes. Am J Physiol Lung Cell Mol Physiol. 2022 03 01; 322(3):L420-L437. Boecking CA, Walentek P, Zlock LT, Sun DI, Wolters PJ, Ishikawa H, Jin BJ, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE. PMID: 35080188; PMCID: PMC8917940.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder. Sci Rep. 2021 11 09; 11(1):21962. Tradtrantip L, Yeaman MR, Verkman AS. PMID: 34753987; PMCID: PMC8578624.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Chloride transport modulators as drug candidates. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C932-C946. Verkman AS, Galietta LJV. PMID: 34644122; PMCID: PMC8714991.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    14. Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake. J Gen Physiol. 2021 08 02; 153(8). Smith AJ, Akdemir G, Wadhwa M, Song D, Verkman AS. PMID: 34128962; PMCID: PMC8210582.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. JCI Insight. 2021 06 08; 6(11). Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS. PMID: 34100381; PMCID: PMC8262356.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats. Kidney Int. 2021 08; 100(2):311-320. Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS. PMID: 33836171; PMCID: PMC8319106.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    17. Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas. JCI Insight. 2021 02 22; 6(4). Oak AA, Chhetri PD, Rivera AA, Verkman AS, Cil O. PMID: 33400691; PMCID: PMC7934922.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. Targeting the complement system in neuromyelitis optica spectrum disorder. Expert Opin Biol Ther. 2021 08; 21(8):1073-1086. Asavapanumas N, Tradtrantip L, Verkman AS. PMID: 33513036; PMCID: PMC8316261.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    19. Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation. PLoS One. 2020; 15(11):e0238484. Nalle SC, Barreira da Silva R, Zhang H, Decker M, Chalouni C, Xu M, Posthuma G, de Mazière A, Klumperman J, Baz Morelli A, Fleire SJ, Verkman AS, Trombetta ES, Albert ML, Mellman I. PMID: 33232321; PMCID: PMC7685505.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury. Nat Commun. 2020 11 09; 11(1):5666. Hara-Chikuma M, Tanaka M, Verkman AS, Yasui M. PMID: 33168815; PMCID: PMC7653938.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport. Transl Vis Sci Technol. 2020 10; 9(11):20. Pasricha ND, Smith AJ, Levin MH, Schallhorn JM, Verkman AS. PMID: 33117611; PMCID: PMC7571274.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. 1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants. Eur J Med Chem. 2021 Jan 01; 209:112888. Son JH, Phuan PW, Zhu JS, Lipman E, Cheung A, Tsui KY, Tantillo DJ, Verkman AS, Haggie PM, Kurth MJ. PMID: 33092904; PMCID: PMC7744356.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation. J Cyst Fibros. 2021 05; 20(3):452-459. Phuan PW, Haggie PM, Tan JA, Rivera AA, Finkbeiner WE, Nielson DW, Thomas MM, Janahi IA, Verkman AS. PMID: 32674984; PMCID: PMC7854863.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    24. Current and potential future applications of human stem cell models in drug development. J Clin Invest. 2020 07 01; 130(7):3342-3344. Donowitz M, Turner JR, Verkman AS, Zachos NC. PMID: 32452833; PMCID: PMC7324189.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 04 01; 130(4):2041-2053. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. PMID: 31961827; PMCID: PMC7108932.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    26. Emerging therapeutic targets for neuromyelitis optica spectrum disorder. Expert Opin Ther Targets. 2020 03; 24(3):219-229. Tradtrantip L, Asavapanumas N, Verkman AS. PMID: 32070155; PMCID: PMC7941255.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    27. Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye. J Ocul Pharmacol Ther. 2020 04; 36(3):147-153. Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS. PMID: 31934802; PMCID: PMC7175624.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    28. Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. Sci Rep. 2019 11 27; 9(1):17640. Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS. PMID: 31776420; PMCID: PMC6881293.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    29. Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders. Neuropharmacology. 2020 01 01; 162:107827. Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS. PMID: 31654702; PMCID: PMC7882122.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings. Brain Pathol. 2020 01; 30(1):13-25. Duan T, Verkman AS. PMID: 31587392; PMCID: PMC7034663.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    31. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem. 2019 09 12; 62(17):8330-8337. Lee S, Cil O, Haggie PM, Verkman AS. PMID: 31389695; PMCID: PMC7034394.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Diabetes insipidus. Nat Rev Dis Primers. 2019 08 08; 5(1):54. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS. PMID: 31395885.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    33. Rebuttal from Alex J. Smith and Alan S. Verkman. J Physiol. 2019 09; 597(17):4427-4428. Smith AJ, Verkman AS. PMID: 31389015; PMCID: PMC6939754.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    34. CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin-4 independent. J Physiol. 2019 09; 597(17):4421-4424. Smith AJ, Verkman AS. PMID: 31389038; PMCID: PMC6717017.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    35. Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. Sci Rep. 2019 07 16; 9(1):10310. Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. PMID: 31311979; PMCID: PMC6635361.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB J. 2019 10; 33(10):11247-11257. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. PMID: 31299174; PMCID: PMC6766656.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    37. Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity. Acta Neuropathol Commun. 2019 07 11; 7(1):112. Duan T, Smith AJ, Verkman AS. PMID: 31296268; PMCID: PMC6621951.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    38. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorg Med Chem Lett. 2019 08 15; 29(16):2119-2123. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. PMID: 31281021; PMCID: PMC6690761.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    39. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. FASEB J. 2019 10; 33(10):10924-10934. Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. PMID: 31268738; PMCID: PMC6766649.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    40. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta Neuropathol Commun. 2019 05 08; 7(1):74. Smith AJ, Duan T, Verkman AS. PMID: 31068220; PMCID: PMC6506955.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    41. CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2019 Mar 09; 16(1):57. Tradtrantip L, Duan T, Yeaman MR, Verkman AS. PMID: 30851734; PMCID: PMC6408857.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 02 21; 4(4). Duan T, Cil O, Thiagarajah JR, Verkman AS. PMID: 30668547; PMCID: PMC6478423.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    43. Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. FASEB J. 2019 05; 33(5):6185-6196. Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B. PMID: 30768374; PMCID: PMC6463927.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    44. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cell Mol Gastroenterol Hepatol. 2019; 7(3):641-653. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. PMID: 30659943; PMCID: PMC6438990.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    45. Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. J Neuropathol Exp Neurol. 2019 01 01; 78(1):47-56. Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS. PMID: 30500945; PMCID: PMC6657442.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    46. Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2018 Oct 22; 15(1):294. Duan T, Smith AJ, Verkman AS. PMID: 30348195; PMCID: PMC6198534.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    47. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight. 2018 07 26; 3(14). Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. PMID: 30046015; PMCID: PMC6124422.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    48. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. J Cyst Fibros. 2018 09; 17(5):595-606. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. PMID: 29903467; PMCID: PMC6436558.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    49. Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Anal Chem. 2018 06 19; 90(12):7675-7681. Jin BJ, Lee S, Verkman AS. PMID: 29779372; PMCID: PMC6461040.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis. JCI Insight. 2018 05 17; 3(10). Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW. PMID: 29769447; PMCID: PMC6012506.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    51. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 04 12; 61(7):3209-3217. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. PMID: 29589443; PMCID: PMC5976253.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    52. ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov. 2018 09; 23(8):823-831. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. PMID: 29533733; PMCID: PMC6133293.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    53. Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica. Neuropharmacology. 2018 05 01; 133:345-353. Tradtrantip L, Felix CM, Spirig R, Morelli AB, Verkman AS. PMID: 29428821; PMCID: PMC6322534.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    54. The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. J Cell Mol Med. 2018 03; 22(3):2039-2040. Verkman AS, Yao X, Smith AJ. PMID: 29363875; PMCID: PMC5824395.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    55. The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB J. 2018 02; 32(2):543-551. Smith AJ, Verkman AS. PMID: 29101220; PMCID: PMC5888402.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    56. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert Opin Ther Targets. 2017 12; 21(12):1161-1170. Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO. PMID: 29072508; PMCID: PMC6481624.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    57. Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4506-4513. Felix CM, Lee S, Levin MH, Verkman AS. PMID: 28873176; PMCID: PMC5584707.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    58. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. Elife. 2017 08 21; 6. Smith AJ, Yao X, Dix JA, Jin BJ, Verkman AS. PMID: 28826498; PMCID: PMC5578736.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    59. Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 07 27; 5(1):57. Yao X, Verkman AS. PMID: 28750658; PMCID: PMC5532786.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    60. Mechanisms of Autoantibody-Induced Pathology. Front Immunol. 2017; 8:603. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. PMID: 28620373; PMCID: PMC5449453.
      View in: PubMed   Mentions: 206     Fields:    
    61. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta Neuropathol. 2017 07; 134(1):35-44. Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS. PMID: 28567523; PMCID: PMC5600280.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    62. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 06 08; 60(11):4626-4635. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. PMID: 28493701; PMCID: PMC5516794.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    63. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochim Biophys Acta Biomembr. 2017 Aug; 1859(8):1326-1334. Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O. PMID: 28477975; PMCID: PMC5581535.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    64. Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1231-1241. Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B. PMID: 28344130.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    65. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 03 23; 60(6):2401-2410. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. PMID: 28230981; PMCID: PMC5463557.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    66. Microfluidic platform for rapid measurement of transepithelial water transport. Lab Chip. 2017 02 28; 17(5):887-895. Jin BJ, Verkman AS. PMID: 28184395; PMCID: PMC5453641.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    67. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 Feb 17; 5(1):15. Yao X, Verkman AS. PMID: 28212662; PMCID: PMC5316191.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    68. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. J Med Chem. 2017 02 09; 60(3):1210-1218. Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS. PMID: 28099811; PMCID: PMC5453640.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    69. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. PMID: 28049834; PMCID: PMC5255594.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    70. Aquaporin-Targeted Therapeutics: State-of-the-Field. Adv Exp Med Biol. 2017; 969:239-250. Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS. PMID: 28258578; PMCID: PMC5628614.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    71. Aquaporin Water Channels and Hydrocephalus. Pediatr Neurosurg. 2017; 52(6):409-416. Verkman AS, Tradtrantip L, Smith AJ, Yao X. PMID: 27978530; PMCID: PMC5969073.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    72. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14781-14786. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. PMID: 27940915; PMCID: PMC5187685.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    73. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. J Biol Chem. 2017 01 20; 292(3):771-785. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 27895116; PMCID: PMC5247652.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    74. Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. J Gen Physiol. 2016 12; 148(6):489-501. Jin BJ, Smith AJ, Verkman AS. PMID: 27836940; PMCID: PMC5129742.
      View in: PubMed   Mentions: 99     Fields:    Translation:Cells
    75. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 02; 31(2):751-760. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. PMID: 27871064; PMCID: PMC5240666.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    76. Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. J Neuroinflammation. 2016 10 20; 13(1):275. Felix CM, Levin MH, Verkman AS. PMID: 27765056; PMCID: PMC5072328.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    77. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. PMID: 27815136; PMCID: PMC5453637.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    78. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. PMID: 27570835; PMCID: PMC4996281.
      View in: PubMed   Mentions: 21     Fields:    
    79. Aquaporin gene therapy for disorders of cholestasis? Hepatology. 2016 08; 64(2):344-6. Tradtrantip L, Verkman AS. PMID: 27115396; PMCID: PMC5687515.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    80. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Sci Rep. 2016 05 11; 6:25781. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K. PMID: 27165276; PMCID: PMC4863152.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    81. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. PMID: 27153921; PMCID: PMC5118489.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    82. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun. 2016 04 26; 4(1):42. Yao X, Su T, Verkman AS. PMID: 27117475; PMCID: PMC4845317.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    83. Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1. Mol Pharmacol. 2016 06; 89(6):686-93. Esteva-Font C, Jin BJ, Lee S, Phuan PW, Anderson MO, Verkman AS. PMID: 26993802; PMCID: PMC4885500.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    84. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J. 2016 06; 30(6):2187-97. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. PMID: 26932931; PMCID: PMC4871793.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    85. Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease. FASEB J. 2016 05; 30(5):1789-97. Flores AM, Casey SD, Felix CM, Phuan PW, Verkman AS, Levin MH. PMID: 26842854; PMCID: PMC4836376.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    86. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. J Enzyme Inhib Med Chem. 2016 Dec; 31(6):1362-8. Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO. PMID: 26796863; PMCID: PMC4958041.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    87. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. J Cereb Blood Flow Metab. 2017 01; 37(1):277-290. Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J. PMID: 26767580; PMCID: PMC5363745.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    88. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. PMID: 27127798; PMCID: PMC4844355.
      View in: PubMed   Mentions: 29     Fields:    
    89. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophys J. 2015 Dec 15; 109(12):2511-2522. Smith AJ, Verkman AS. PMID: 26682810; PMCID: PMC4699884.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    90. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. J Cyst Fibros. 2015 Nov; 14(6):700-5. Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. PMID: 26474804; PMCID: PMC4786369.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    91. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci. 2015 Sep 30; 35(39):13525-37. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D. PMID: 26424896; PMCID: PMC4588615.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    92. Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab Chip. 2015 Aug 21; 15(16):3380-90. Jin BJ, Esteva-Font C, Verkman AS. PMID: 26159099; PMCID: PMC4706553.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    93. Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action. Mol Pharmacol. 2015 Oct; 88(4):791-9. Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 26245207; PMCID: PMC4576684.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    94. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct; 88(4):689-96. Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. PMID: 26174774; PMCID: PMC4576686.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    95. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):446-57. Thiagarajah JR, Donowitz M, Verkman AS. PMID: 26122478; PMCID: PMC4786374.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    96. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis. Nat Commun. 2015 Jun 23; 6:7454. Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS. PMID: 26100668; PMCID: PMC5628617.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    97. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. J Neurotrauma. 2015 Oct 01; 32(19):1458-64. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS. PMID: 25790314; PMCID: PMC4589265.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    98. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015 Aug; 88(2):311-20. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. PMID: 25993324; PMCID: PMC4523423.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    99. Muddying the water in brain edema? Trends Neurosci. 2015 Jun; 38(6):331-2. Smith AJ, Jin BJ, Verkman AS. PMID: 25980601; PMCID: PMC4739497.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    100. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia. 2015 Oct; 63(10):1860-9. Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS. PMID: 25944186; PMCID: PMC4743984.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    101. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. J Biol Chem. 2015 May 08; 290(19):12123-34. Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. PMID: 25792738; PMCID: PMC4424347.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    102. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochim Biophys Acta. 2015 May; 1848(5):1075-80. Esteva-Font C, Phuan PW, Lee S, Su T, Anderson MO, Verkman AS. PMID: 25613743; PMCID: PMC4364388.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    103. Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons. Exp Neurol. 2015 Mar; 265:152-9. Zhang H, Verkman AS. PMID: 25585012; PMCID: PMC4346453.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    104. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. FASEB J. 2015 Apr; 29(4):1551-63. Wang W, Li F, Sun Y, Lei L, Zhou H, Lei T, Xia Y, Verkman AS, Yang B. PMID: 25573755; PMCID: PMC4396615.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    105. Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors. Medchemcomm. 2015; 6:1278-1284. Lee S, Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. PMID: 26191399; PMCID: PMC4501499.
      View in: PubMed   Mentions: 4  
    106. Urea transporter proteins as targets for small-molecule diuretics. Nat Rev Nephrol. 2015 Feb; 11(2):113-23. Esteva-Font C, Anderson MO, Verkman AS. PMID: 25488859; PMCID: PMC4743986.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    107. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neurosci Lett. 2015 Jan 01; 584:368-72. Yao X, Derugin N, Manley GT, Verkman AS. PMID: 25449874; PMCID: PMC4737527.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    108. ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5840-5844. Ye L, Hu B, El-Badri F, Hudson BM, Phuan PW, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25452003; PMCID: PMC4255153.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    109. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle Nerve. 2014 Nov; 50(5):859-62. Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman AS, Bollen AW, Ralph JW. PMID: 24862586; PMCID: PMC4306419.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    110. Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. PLoS One. 2014; 9(9):e106824. Tradtrantip L, Asavapanumas N, Phuan PW, Verkman AS. PMID: 25191939; PMCID: PMC4156393.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    111. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nat Rev Neurol. 2014 Sep; 10(9):493-506. Papadopoulos MC, Bennett JL, Verkman AS. PMID: 25112508; PMCID: PMC4229040.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    112. Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking. J Med Chem. 2014 Aug 14; 57(15):6729-38. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25061695; PMCID: PMC4136667.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    113. Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Sci Transl Med. 2014 Jul 23; 6(246):246ra97. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. PMID: 25101887; PMCID: PMC4467693.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    114. Inhibitor(s) of the classical complement pathway in mouse serum limit the utility of mice as experimental models of neuromyelitis optica. Mol Immunol. 2014 Nov; 62(1):104-13. Ratelade J, Verkman AS. PMID: 24980869; PMCID: PMC4306420.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    115. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors. FASEB J. 2014 Sep; 28(9):3878-90. Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. PMID: 24843071; PMCID: PMC4139901.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    116. Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury. Acta Neuropathol Commun. 2014 Apr 24; 2:48. Asavapanumas N, Verkman AS. PMID: 24758159; PMCID: PMC4234989.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    117. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul; 86(1):42-51. Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. PMID: 24737137; PMCID: PMC4054004.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    118. Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neurosci Lett. 2014 Jun 27; 574:70-5. Akdemir G, Ratelade J, Asavapanumas N, Verkman AS. PMID: 24717641; PMCID: PMC4306422.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    119. Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids. Biomicrofluidics. 2014 Mar; 8(2):024106. Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS. PMID: 24738013; PMCID: PMC3976466.
      View in: PubMed   Mentions: 22  
    120. Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. J Autoimmun. 2014 Sep; 53:67-77. Zhang H, Verkman AS. PMID: 24698947; PMCID: PMC4162764.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    121. Aquaporins: important but elusive drug targets. Nat Rev Drug Discov. 2014 Apr; 13(4):259-77. Verkman AS, Anderson MO, Papadopoulos MC. PMID: 24625825; PMCID: PMC4067137.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimalsCells
    122. Human immunoglobulin G reduces the pathogenicity of aquaporin-4 autoantibodies in neuromyelitis optica. Exp Neurol. 2014 May; 255:145-53. Ratelade J, Smith AJ, Verkman AS. PMID: 24636863; PMCID: PMC4291172.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    123. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2674. Tradtrantip L, Ko EA, Verkman AS. PMID: 24551253; PMCID: PMC3923670.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    124. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. J Cell Biol. 2014 Feb 17; 204(4):559-73. Smith AJ, Jin BJ, Ratelade J, Verkman AS. PMID: 24515349; PMCID: PMC3926963.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    125. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. J Neuroinflammation. 2014 Jan 27; 11:16. Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS. PMID: 24468108; PMCID: PMC3909205.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    126. Small-molecule inhibitors of urea transporters. Subcell Biochem. 2014; 73:165-77. Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. PMID: 25298345; PMCID: PMC4306426.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    127. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J. 2014 Mar; 28(3):1446-53. Esteva-Font C, Jin BJ, Verkman AS. PMID: 24334548; PMCID: PMC3929666.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    128. Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure. Neurobiol Dis. 2014 Mar; 63:222-8. Rama Rao KV, Verkman AS, Curtis KM, Norenberg MD. PMID: 24321433; PMCID: PMC3982919.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    129. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clin Gastroenterol Hepatol. 2014 Feb; 12(2):204-9. Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. PMID: 24316107; PMCID: PMC3935719.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    130. Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia. FASEB J. 2014 Feb; 28(2):791-801. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. PMID: 24200884; PMCID: PMC3898646.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    131. Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG. Acta Neuropathol. 2014 Apr; 127(4):539-51. Asavapanumas N, Ratelade J, Verkman AS. PMID: 24190619; PMCID: PMC3954950.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    132. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB J. 2014 Feb; 28(2):705-14. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS. PMID: 24186965; PMCID: PMC3898642.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    133. Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO. Brain Pathol. 2013 Nov; 23(6):684-95. Verkman AS, Phuan PW, Asavapanumas N, Tradtrantip L. PMID: 24118484; PMCID: PMC3890327.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    134. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clin Gastroenterol Hepatol. 2014 Jan; 12(1):27-31. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. PMID: 24184676; PMCID: PMC3926754.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    135. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds. Lab Chip. 2013 Oct 07; 13(19):3862-7. Jin BJ, Ko EA, Namkung W, Verkman AS. PMID: 23907501; PMCID: PMC3904508.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    136. A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol. 2013 Oct 24; 20(10):1235-44. Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. PMID: 24055006; PMCID: PMC3890325.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    137. Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014 Jul; 63(7):1120-9. Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS. PMID: 24052273; PMCID: PMC4048772.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    138. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Acta Neuropathol. 2013 Nov; 126(5):699-709. Ratelade J, Asavapanumas N, Ritchie AM, Wemlinger S, Bennett JL, Verkman AS. PMID: 23995423; PMCID: PMC3890328.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    139. Chloride channel-targeted therapy for secretory diarrheas. Curr Opin Pharmacol. 2013 Dec; 13(6):888-94. Thiagarajah JR, Verkman AS. PMID: 23992767; PMCID: PMC3890324.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    140. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2014 Jan; 16(1):1-14. Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM. PMID: 23910799; PMCID: PMC3909729.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    141. Diffusion in the extracellular space in brain and tumors. Phys Biol. 2013 08; 10(4):045003. Verkman AS. PMID: 23913007; PMCID: PMC3937300.
      View in: PubMed   Mentions: 14     Fields:    
    142. Response to "Diffusion versus convection". J Gen Physiol. 2013 Aug; 142(2):173. Jin BJ, Thiagarajah JR, Verkman AS. PMID: 23898009; PMCID: PMC3727305.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    143. Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harb Perspect Med. 2013 Jul 01; 3(7). Rowe SM, Verkman AS. PMID: 23818513; PMCID: PMC3685879.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    144. Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist. Mol Pharmacol. 2013 Sep; 84(3):384-92. Namkung W, Park J, Seo Y, Verkman AS. PMID: 23788656; PMCID: PMC3876813.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    145. Response to "When can AQP4 assist transporter-mediated K⁺ uptake?". J Gen Physiol. 2013 Jul; 142(1):91-2. Jin BJ, Zhang H, Binder DK, Verkman AS. PMID: 23752331; PMCID: PMC3691444.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    146. C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica. Acta Neuropathol. 2013 Jun; 125(6):829-40. Phuan PW, Zhang H, Asavapanumas N, Leviten M, Rosenthal A, Tradtrantip L, Verkman AS. PMID: 23677375; PMCID: PMC3941651.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    147. Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nat Chem Biol. 2013 Jul; 9(7):444-54. Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. PMID: 23666117; PMCID: PMC3840170.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    148. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 09; 4(5):456-459. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. PMID: 23814642; PMCID: PMC3694630.
      View in: PubMed   Mentions: 9  
    149. Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase. Mol Pharmacol. 2013 Jun; 83(6):1268-75. Tradtrantip L, Asavapanumas N, Verkman AS. PMID: 23571414; PMCID: PMC3657102.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    150. Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. J Clin Invest. 2013 May; 123(5):2306-16. Zhang H, Verkman AS. PMID: 23563310; PMCID: PMC3635742.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    151. 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorg Med Chem Lett. 2013 Jun 01; 23(11):3338-41. Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS, Anderson MO. PMID: 23597791; PMCID: PMC3954708.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    152. Optic neuritis in neuromyelitis optica. Prog Retin Eye Res. 2013 Sep; 36:159-71. Levin MH, Bennett JL, Verkman AS. PMID: 23545439; PMCID: PMC3770284.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    153. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013 Apr; 14(4):265-77. Papadopoulos MC, Verkman AS. PMID: 23481483; PMCID: PMC3732112.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimalsCells
    154. Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. J Gen Physiol. 2013 Feb; 141(2):261-72. Jin BJ, Thiagarajah JR, Verkman AS. PMID: 23359285; PMCID: PMC3557305.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    155. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol. 2013 Feb; 168(3):773-84. Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA. PMID: 22946562; PMCID: PMC3579294.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    156. Aquaporins. Curr Biol. 2013 Jan 21; 23(2):R52-5. Verkman AS. PMID: 23347934; PMCID: PMC3590904.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    157. CFTR inhibitors. Curr Pharm Des. 2013; 19(19):3529-41. Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. PMID: 23331030; PMCID: PMC4012685.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    158. Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. J Gen Physiol. 2013 Jan; 141(1):119-32. Jin BJ, Zhang H, Binder DK, Verkman AS. PMID: 23277478; PMCID: PMC3536523.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    159. Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions. Neuroreport. 2012 Dec 19; 23(18):1044-7. Saadoun S, Bridges LR, Verkman AS, Papadopoulos MC. PMID: 23108041; PMCID: PMC3590012.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    160. Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility. J Biol Chem. 2012 Dec 21; 287(52):43630-8. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. PMID: 23115232; PMCID: PMC3527949.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    161. Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody. Ann Neurol. 2013 Jan; 73(1):77-85. Tradtrantip L, Ratelade J, Zhang H, Verkman AS. PMID: 23055279; PMCID: PMC3567850.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    162. A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4. J Biol Chem. 2012 Oct 26; 287(44):36837-44. Phuan PW, Anderson MO, Tradtrantip L, Zhang H, Tan J, Lam C, Bennett JL, Verkman AS. PMID: 22989877; PMCID: PMC3481286.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    163. Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly. Glia. 2012 Dec; 60(12):2027-39. Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22987455; PMCID: PMC3586219.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    164. Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Mol Biol Cell. 2012 Nov; 23(21):4188-202. Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL. PMID: 22973054; PMCID: PMC3484098.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    165. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med. 2012 Sep 24; 209(10):1743-52. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y. PMID: 22927550; PMCID: PMC3457725.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    166. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep; 92(3):287-90. Thiagarajah JR, Verkman AS. PMID: 22850599; PMCID: PMC3643514.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    167. Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis. Bioorg Med Chem. 2012 Sep 01; 20(17):5247-53. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. PMID: 22841006; PMCID: PMC3419814.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    168. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes. J Cell Sci. 2012 Sep 15; 125(Pt 18):4405-12. Rossi A, Moritz TJ, Ratelade J, Verkman AS. PMID: 22718347; PMCID: PMC3516444.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    169. Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. J Med Chem. 2012 Jun 28; 55(12):5942-50. Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS. PMID: 22694147; PMCID: PMC3590912.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    170. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. Int J Biochem Cell Biol. 2012 Sep; 44(9):1519-30. Ratelade J, Verkman AS. PMID: 22713791; PMCID: PMC3676174.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    171. Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem. 2012 Jul 15; 20(14):4237-44. Kumar S, Namkung W, Verkman AS, Sharma PK. PMID: 22739085; PMCID: PMC3643516.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    172. Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. PLoS One. 2012; 7(5):e38030. Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS. PMID: 22666439; PMCID: PMC3364195.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    173. Aquaporin 4 and neuromyelitis optica. Lancet Neurol. 2012 Jun; 11(6):535-44. Papadopoulos MC, Verkman AS. PMID: 22608667; PMCID: PMC3678971.
      View in: PubMed   Mentions: 224     Fields:    Translation:Humans
    174. Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):E1511; author reply E1512. Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22589299; PMCID: PMC3386066.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    175. Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss. Acta Neuropathol. 2012 Jun; 123(6):861-72. Ratelade J, Zhang H, Saadoun S, Bennett JL, Papadopoulos MC, Verkman AS. PMID: 22526022; PMCID: PMC3581313.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    176. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul; 23(7):1210-20. Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS. PMID: 22491419; PMCID: PMC3380644.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    177. Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays. J Biol Chem. 2012 Apr 20; 287(17):13829-39. Phuan PW, Ratelade J, Rossi A, Tradtrantip L, Verkman AS. PMID: 22393049; PMCID: PMC3340190.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    178. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol. 2012 Mar; 71(3):323-33. Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. PMID: 22374891; PMCID: PMC3643520.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    179. Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB J. 2012 May; 26(5):2197-208. Tradtrantip L, Zhang H, Anderson MO, Saadoun S, Phuan PW, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22319008; PMCID: PMC3336779.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    180. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol. 2012 Mar; 71(3):314-22. Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. PMID: 22271321; PMCID: PMC3314396.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    181. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein. J Med Chem. 2012 Feb 09; 55(3):1242-51. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 22214395; PMCID: PMC3277286.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    182. Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1602-5. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. PMID: 22281185; PMCID: PMC3274619.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    183. Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion. Methods Enzymol. 2012; 504:341-54. Verkman AS, Rossi A, Crane JM. PMID: 22264543; PMCID: PMC3579562.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    184. Aquaporins in clinical medicine. Annu Rev Med. 2012; 63:303-16. Verkman AS. PMID: 22248325; PMCID: PMC3319404.
      View in: PubMed   Mentions: 167     Fields:    Translation:Humans
    185. Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras. J Gen Physiol. 2012 Jan; 139(1):83-91. Baumgart F, Rossi A, Verkman AS. PMID: 22200949; PMCID: PMC3250104.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    186. CFTR: folding, misfolding and correcting the ΔF508 conformational defect. Trends Mol Med. 2012 Feb; 18(2):81-91. Lukacs GL, Verkman AS. PMID: 22138491; PMCID: PMC3643519.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    187. Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. PMID: 22034937; PMCID: PMC3245868.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    188. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. Ann Neurol. 2011 Dec; 70(6):943-54. Zhang H, Bennett JL, Verkman AS. PMID: 22069219; PMCID: PMC3319401.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    189. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. J Biol Chem. 2011 Dec 30; 286(52):45156-64. Ratelade J, Bennett JL, Verkman AS. PMID: 22069320; PMCID: PMC3247969.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    190. Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays. Traffic. 2012 Jan; 13(1):43-53. Rossi A, Baumgart F, van Hoek AN, Verkman AS. PMID: 21981006; PMCID: PMC3319398.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    191. Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema. PLoS One. 2011; 6(11):e27412. Ratelade J, Bennett JL, Verkman AS. PMID: 22076159; PMCID: PMC3208637.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    192. Protein trafficking rates assessed by quantum dot quenching with bromocresol green. Traffic. 2012 Jan; 13(1):25-9. Valentine CD, Verkman AS, Haggie PM. PMID: 21951589; PMCID: PMC3237755.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    193. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 2011 Nov; 25(11):4048-62. Namkung W, Yao Z, Finkbeiner WE, Verkman AS. PMID: 21836025; PMCID: PMC3205834.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    194. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11; 54(15):5468-77. Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. PMID: 21707078; PMCID: PMC3314378.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    195. Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis. Mol Pharmacol. 2011 Oct; 80(4):683-93. Phuan PW, Yang B, Knapp JM, Wood AB, Lukacs GL, Kurth MJ, Verkman AS. PMID: 21730204; PMCID: PMC3187530.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    196. Aquaporins at a glance. J Cell Sci. 2011 Jul 01; 124(Pt 13):2107-12. Verkman AS. PMID: 21670197.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    197. Model of aquaporin-4 supramolecular assembly in orthogonal arrays based on heterotetrameric association of M1-M23 isoforms. Biophys J. 2011 Jun 22; 100(12):2936-45. Jin BJ, Rossi A, Verkman AS. PMID: 21689527; PMCID: PMC3123972.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    198. Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms. J Neuroimmunol. 2011 Jul; 236(1-2):93-8. Crane JM, Rossi A, Gupta T, Bennett JL, Verkman AS. PMID: 21621278; PMCID: PMC3582392.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    199. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta Pharmacol Sin. 2011 Jun; 32(6):702-10. Verkman AS, Ratelade J, Rossi A, Zhang H, Tradtrantip L. PMID: 21552296; PMCID: PMC3601948.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    200. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci. 2011 Apr 27; 31(17):6392-7. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. PMID: 21525279; PMCID: PMC3107562.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    201. T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. J Neuroimmunol. 2011 Jun; 235(1-2):27-32. Saadoun S, Waters P, Macdonald C, Bridges LR, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. PMID: 21492943.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    202. Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding. Glia. 2011 Jul; 59(7):1056-63. Rossi A, Crane JM, Verkman AS. PMID: 21491501; PMCID: PMC3327643.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    203. Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB J. 2011 Jul; 25(7):2325-32. Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. PMID: 21427214; PMCID: PMC3114535.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    204. Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. J Biol Chem. 2011 May 06; 286(18):16516-24. Crane JM, Lam C, Rossi A, Gupta T, Bennett JL, Verkman AS. PMID: 21454592; PMCID: PMC3091256.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    205. Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing. European J Org Chem. 2011 Mar 01; 2011(7):1242-1248. Carpenter RD, Verkman AS. PMID: 23914138; PMCID: PMC3729919.
      View in: PubMed   Mentions: 3  
    206. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J. 2011 May; 25(5):1556-66. Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS. PMID: 21257712; PMCID: PMC3079299.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    207. Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. J Invest Dermatol. 2011 Apr; 131(4):865-73. Nakahigashi K, Kabashima K, Ikoma A, Verkman AS, Miyachi Y, Hara-Chikuma M. PMID: 21191421.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    208. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21; 286(3):2365-74. Namkung W, Phuan PW, Verkman AS. PMID: 21084298; PMCID: PMC3023530.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansCells
    209. Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. Mol Cell Neurosci. 2011 Jan; 46(1):318-24. Wang D, Nykanen M, Yang N, Winlaw D, North K, Verkman AS, Owler BK. PMID: 21040788.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    210. Airway surface liquid depth imaged by surface laser reflectance microscopy. J Gen Physiol. 2010 Sep; 136(3):353-62. Thiagarajah JR, Song Y, Derichs N, Verkman AS. PMID: 20713545; PMCID: PMC2931148.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    211. Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning. Biophys J. 2010 Aug 09; 99(4):1284-91. Zhang H, Verkman AS. PMID: 20713014; PMCID: PMC2920647.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    212. Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J. 2010 Nov; 24(11):4178-86. Namkung W, Thiagarajah JR, Phuan PW, Verkman AS. PMID: 20581223; PMCID: PMC2974422.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    213. CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. Mol Biol Cell. 2010 Aug 01; 21(15):2639-48. Namkung W, Finkbeiner WE, Verkman AS. PMID: 20554763; PMCID: PMC2912350.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    214. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010 Jun; 67(6):794-801. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. PMID: 20517941.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    215. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. J Med Chem. 2010 May 13; 53(9):3772-81. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. PMID: 20373765; PMCID: PMC3109609.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    216. Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors. Synlett. 2010 Apr 01; 2010(7):1063-1066. Yu GJ, Yang B, Verkman AS, Kurth MJ. PMID: 23710112; PMCID: PMC3662250.
      View in: PubMed   Mentions: 5  
    217. Synthesis of a sensitive and selective potassium-sensing fluoroionophore. Org Lett. 2010 Mar 19; 12(6):1160-3. Carpenter RD, Verkman AS. PMID: 20148571; PMCID: PMC3315285.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    218. Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. Neuroscience. 2010 Apr 28; 167(1):60-7. Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. PMID: 20132873; PMCID: PMC2852644.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    219. Aquaporin-4 (AQP4) associations and array dynamics probed by photobleaching and single-molecule analysis of green fluorescent protein-AQP4 chimeras. J Biol Chem. 2010 Mar 12; 285(11):8163-70. Tajima M, Crane JM, Verkman AS. PMID: 20071343; PMCID: PMC2832968.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    220. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain. 2010 Feb; 133(Pt 2):349-61. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. PMID: 20047900; PMCID: PMC2822632.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    221. Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells. J Biol Chem. 2009 Dec 18; 284(51):35850-60. Crane JM, Bennett JL, Verkman AS. PMID: 19843522; PMCID: PMC2791014.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    222. Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. J Biol Chem. 2010 Feb 19; 285(8):5896-906. Zhang H, Verkman AS. PMID: 20018876; PMCID: PMC2820815.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    223. Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes. Biophys J. 2009 Dec 02; 97(11):3010-8. Crane JM, Verkman AS. PMID: 19948131; PMCID: PMC2784574.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    224. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):87-91. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ. PMID: 19954980; PMCID: PMC3165007.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    225. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22; 52(20):6447-55. Tradtrantip L, Sonawane ND, Namkung W, Verkman AS. PMID: 19785436; PMCID: PMC3319430.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    226. Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1131-40. Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS. PMID: 19820035; PMCID: PMC2793186.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    227. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan; 77(1):69-78. Tradtrantip L, Namkung W, Verkman AS. PMID: 19808995; PMCID: PMC2802429.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    228. Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles. Neuroscience. 2010 Jul 28; 168(4):892-902. Crane JM, Tajima M, Verkman AS. PMID: 19699275; PMCID: PMC3586212.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    229. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. BMC Neurosci. 2009 Aug 06; 10:94. Li L, Zhang H, Verkman AS. PMID: 19660138; PMCID: PMC3152780.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    230. Aquaporins: translating bench research to human disease. J Exp Biol. 2009 Jun; 212(Pt 11):1707-15. Verkman AS. PMID: 19448080; PMCID: PMC2683014.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    231. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye. J Biol Chem. 2009 Jun 05; 284(23):15916-26. Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS. PMID: 19364771; PMCID: PMC2708887.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    232. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. 2009 Jul 07; 161(3):764-72. Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC. PMID: 19345723.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    233. Sporadic obstructive hydrocephalus in Aqp4 null mice. J Neurosci Res. 2009 Apr; 87(5):1150-5. Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T. PMID: 18951529; PMCID: PMC3582395.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    234. Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L859-67. Haggie PM, Verkman AS. PMID: 19329540; PMCID: PMC2692795.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    235. Extracellular space volume measured by two-color pulsed dye infusion with microfiberoptic fluorescence photodetection. Biophys J. 2009 Mar 18; 96(6):2382-90. Magzoub M, Zhang H, Dix JA, Verkman AS. PMID: 19289063; PMCID: PMC2907719.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    236. Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Exp Eye Res. 2009 Aug; 89(2):159-65. Ruiz-Ederra J, Verkman AS. PMID: 19298815; PMCID: PMC3319399.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
      View in: PubMed   Mentions: 2  
    238. Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging. J Cell Sci. 2009 Mar 15; 122(Pt 6):813-21. Crane JM, Verkman AS. PMID: 19240114; PMCID: PMC2714425.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    239. The expression of differentiation markers in aquaporin-3 deficient epidermis. Arch Dermatol Res. 2009 Mar; 301(3):245-52. Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, Miyachi Y. PMID: 19184071; PMCID: PMC3582396.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    240. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G816-22. Li L, Zhang H, Ma T, Verkman AS. PMID: 19179619; PMCID: PMC2670675.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    241. In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2132-8. Ruiz-Ederra J, Levin MH, Verkman AS. PMID: 19136711; PMCID: PMC2904304.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    242. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem. 2009 Mar 20; 284(12):7681-6. Haggie PM, Verkman AS. PMID: 19136560; PMCID: PMC2658062.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    243. Knock-out models reveal new aquaporin functions. Handb Exp Pharmacol. 2009; (190):359-81. Verkman AS. PMID: 19096787; PMCID: PMC3595129.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    244. Aquaporin water channels in transepithelial fluid transport. J Med Invest. 2009; 56 Suppl:179-84. Tradtrantip L, Tajima M, Li L, Verkman AS. PMID: 20224178; PMCID: PMC3601945.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    245. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J. 2009 Feb; 23(2):503-12. Yang B, Zhao D, Verkman AS. PMID: 18854434; PMCID: PMC2630791.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    246. Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Mol Pharmacol. 2009 Jan; 75(1):134-42. Tradtrantip L, Yangthara B, Padmawar P, Morrison C, Verkman AS. PMID: 18824527; PMCID: PMC2685055.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    247. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem. 2008 Oct 09; 51(19):6044-54. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 18788728; PMCID: PMC3167067.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    248. Evidence against involvement of aquaporin-4 in cell-cell adhesion. J Mol Biol. 2008 Oct 24; 382(5):1136-43. Zhang H, Verkman AS. PMID: 18708067; PMCID: PMC3319413.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    249. Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorg Med Chem. 2008 Sep 01; 16(17):8187-95. Sonawane ND, Verkman AS. PMID: 18691893; PMCID: PMC2577561.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    250. Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chem Biol. 2008 Jul 21; 15(7):718-28. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 18635008; PMCID: PMC3322358.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    251. Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. J Biol Chem. 2008 Aug 29; 283(35):23510-3. Haggie PM, Verkman AS. PMID: 18617526; PMCID: PMC2527093.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    252. Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis. Biochem J. 2008 Jul 01; 413(1):135-42. Caci E, Caputo A, Hinzpeter A, Arous N, Fanen P, Sonawane N, Verkman AS, Ravazzolo R, Zegarra-Moran O, Galietta LJ. PMID: 18366345.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    253. Roles of aquaporin-3 in the epidermis. J Invest Dermatol. 2008 Sep; 128(9):2145-51. Hara-Chikuma M, Verkman AS. PMID: 18548108.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    254. Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorg Med Chem. 2008 Aug 01; 16(15):7489-93. Yang B, Zhang H, Verkman AS. PMID: 18572411; PMCID: PMC3325054.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    255. Cell-based fluorescence screen for K+ channels and transporters using an extracellular triazacryptand-based K+ sensor. J Am Chem Soc. 2008 Jun 25; 130(25):7794-5. Namkung W, Padmawar P, Mills AD, Verkman AS. PMID: 18512924; PMCID: PMC2692188.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    256. Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB J. 2008 Sep; 22(9):3216-23. Lu DC, Zhang H, Zador Z, Verkman AS. PMID: 18511552; PMCID: PMC2518258.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    257. From the farm to the lab: the pig as a new model of cystic fibrosis lung disease. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L238-9. Verkman AS. PMID: 18502814.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    258. Functions of aquaporins in the eye. Prog Retin Eye Res. 2008 Jul; 27(4):420-33. Verkman AS, Ruiz-Ederra J, Levin MH. PMID: 18501660; PMCID: PMC3319433.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    259. Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking. Mol Biol Cell. 2008 Aug; 19(8):3369-78. Crane JM, Van Hoek AN, Skach WR, Verkman AS. PMID: 18495865; PMCID: PMC2488293.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    260. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert Rev Mol Med. 2008 May 16; 10:e13. Verkman AS. PMID: 18482462; PMCID: PMC3601943.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    261. Random-walk model of diffusion in three dimensions in brain extracellular space: comparison with microfiberoptic photobleaching measurements. Biophys J. 2008 Aug; 95(4):1785-94. Jin S, Zador Z, Verkman AS. PMID: 18469079; PMCID: PMC2483768.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    262. Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Semin Nephrol. 2008 May; 28(3):217-26. Verkman AS. PMID: 18519083; PMCID: PMC2692584.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    263. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol. 2008 Jul; 19(7):1300-10. Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS. PMID: 18385427; PMCID: PMC2440296.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    264. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem. 2008 May 30; 283(22):15280-6. Yang B, Zador Z, Verkman AS. PMID: 18375385; PMCID: PMC2397463.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    265. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett. 2008 Apr 15; 18(8):2610-4. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. PMID: 18394886; PMCID: PMC3166558.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    266. Aquaporins--new players in cancer biology. J Mol Med (Berl). 2008 May; 86(5):523-9. Verkman AS, Hara-Chikuma M, Papadopoulos MC. PMID: 18311471; PMCID: PMC3590015.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    267. A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression. Exp Dermatol. 2008 Oct; 17(10):871-2. Verkman AS. PMID: 18312385.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    268. Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity. J Pharmacol Exp Ther. 2008 May; 325(2):529-35. Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS. PMID: 18272811.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    269. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008 Apr; 131(Pt 4):1087-98. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. PMID: 18267965.
      View in: PubMed   Mentions: 97     Fields:    Translation:Animals
    270. Chloride channels as drug targets. Nat Rev Drug Discov. 2009 Feb; 8(2):153-71. Verkman AS, Galietta LJ. PMID: 19153558; PMCID: PMC3601949.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    271. Crowding effects on diffusion in solutions and cells. Annu Rev Biophys. 2008; 37:247-63. Dix JA, Verkman AS. PMID: 18573081.
      View in: PubMed   Mentions: 198     Fields:    Translation:Cells
    272. Potential utility of aquaporin modulators for therapy of brain disorders. Prog Brain Res. 2008; 170:589-601. Papadopoulos MC, Verkman AS. PMID: 18655912; PMCID: PMC3601944.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    273. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol. 2008 Mar; 73(3):758-68. De La Fuente R, Namkung W, Mills A, Verkman AS. PMID: 18083779.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    274. Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. J Mol Med (Berl). 2008 Feb; 86(2):221-31. Hara-Chikuma M, Verkman AS. PMID: 17968524.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    275. Aquaporins and cell migration. Pflugers Arch. 2008 Jul; 456(4):693-700. Papadopoulos MC, Saadoun S, Verkman AS. PMID: 17968585; PMCID: PMC3595095.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimals
    276. Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Mol Cell Biol. 2008 Jan; 28(1):326-32. Hara-Chikuma M, Verkman AS. PMID: 17967887; PMCID: PMC2223314.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    277. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB J. 2008 Mar; 22(3):870-9. Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. PMID: 17965267.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    278. Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4802-10. Ruiz-Ederra J, Verkman AS. PMID: 17898307.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    279. Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane. Biophys J. 2008 Jan 15; 94(2):702-13. Crane JM, Verkman AS. PMID: 17890385; PMCID: PMC2157255.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    280. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 2008 Jan; 22(1):276-84. Magzoub M, Jin S, Verkman AS. PMID: 17761521.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    281. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem. 2007 Oct 26; 282(43):31422-8. Haggie PM, Verkman AS. PMID: 17724021.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    282. Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells. Mol Cell Neurosci. 2008 Jan; 37(1):1-10. Zhang H, Verkman AS. PMID: 17869537; PMCID: PMC2904300.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    283. Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut. 2007 Nov; 56(11):1529-35. Thiagarajah JR, Zhao D, Verkman AS. PMID: 17573386; PMCID: PMC2095633.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    284. Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells. J Biol Chem. 2007 Jul 27; 282(30):21866-72. Ruiz-Ederra J, Zhang H, Verkman AS. PMID: 17525153.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    285. Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels. Biophys J. 2007 Aug 01; 93(3):1079-88. Jin S, Haggie PM, Verkman AS. PMID: 17483157; PMCID: PMC1913154.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    286. Small-molecule vasopressin-2 receptor antagonist identified by a g-protein coupled receptor "pathway" screen. Mol Pharmacol. 2007 Jul; 72(1):86-94. Yangthara B, Mills A, Chatsudthipong V, Tradtrantip L, Verkman AS. PMID: 17435162.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    287. Single particle tracking of complex diffusion in membranes: simulation and detection of barrier, raft, and interaction phenomena. J Phys Chem B. 2007 Apr 12; 111(14):3625-32. Jin S, Verkman AS. PMID: 17388520.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    288. Aquaporin-4 and brain edema. Pediatr Nephrol. 2007 Jun; 22(6):778-84. Papadopoulos MC, Verkman AS. PMID: 17347837; PMCID: PMC6904420.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimals
    289. Role of aquaporins in lung liquid physiology. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):324-30. Verkman AS. PMID: 17369110; PMCID: PMC3315286.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    290. Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology. 2007 Apr; 132(4):1234-44. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 17408659.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    291. Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B. FASEB J. 2007 Feb; 21(2):551-63. Levin MH, de la Fuente R, Verkman AS. PMID: 17202246.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    292. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J. 2007 Jan; 21(1):108-16. Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS. PMID: 17135365.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    293. Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide. FEBS Lett. 2006 Dec 11; 580(28-29):6679-84. Yang B, Kim JK, Verkman AS. PMID: 17126329; PMCID: PMC3582400.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    294. Millisecond association kinetics of K+ with triazacryptand-based K+ indicators measured by fluorescence correlation spectroscopy. J Phys Chem B. 2006 Oct 26; 110(42):21216-21. Magzoub M, Padmawar P, Dix JA, Verkman AS. PMID: 17048948.
      View in: PubMed   Mentions: 9     Fields:    
    295. Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4365-72. Levin MH, Verkman AS. PMID: 17003427.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    296. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell. 2006 Dec; 17(12):4937-45. Haggie PM, Kim JK, Lukacs GL, Verkman AS. PMID: 16987954; PMCID: PMC1679663.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    297. Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening. Br J Pharmacol. 2006 Nov; 149(5):551-9. De La Fuente R, Sonawane ND, Arumainayagam D, Verkman AS. PMID: 16981005; PMCID: PMC2014677.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    298. Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3960-7. Ruiz-Ederra J, Verkman AS. PMID: 16936111.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    299. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L383-95. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. PMID: 16920886.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    300. Aquaporins and CFTR in ocular epithelial fluid transport. J Membr Biol. 2006 Mar; 210(2):105-15. Levin MH, Verkman AS. PMID: 16868675.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    301. Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins. J Biol Chem. 2006 Sep 01; 281(35):25803-12. Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS. PMID: 16829520.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    302. Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J. 2006 Sep; 20(11):1892-4. Hu J, Verkman AS. PMID: 16818469.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    303. Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins. Cell Mol Life Sci. 2006 Jun; 63(12):1386-92. Hara-Chikuma M, Verkman AS. PMID: 16715408.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    304. Roles of aquaporins in kidney revealed by transgenic mice. Semin Nephrol. 2006 May; 26(3):200-8. Verkman AS. PMID: 16713493.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    305. Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int. 2006 May; 69(9):1518-25. Ni J, Verbavatz JM, Rippe A, Boisdé I, Moulin P, Rippe B, Verkman AS, Devuyst O. PMID: 16508653.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    306. Evidence against functionally significant aquaporin expression in mitochondria. J Biol Chem. 2006 Jun 16; 281(24):16202-6. Yang B, Zhao D, Verkman AS. PMID: 16624821.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    307. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. Am J Physiol Cell Physiol. 2006 Sep; 291(3):C417-23. Yang B, Zhao D, Solenov E, Verkman AS. PMID: 16624991.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    308. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia. 2006 Apr 15; 53(6):631-6. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT. PMID: 16470808.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    309. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat Methods. 2006 Apr; 3(4):275-80. Thiagarajah JR, Kim JK, Magzoub M, Verkman AS. PMID: 16554832.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    310. Aquaporins in endothelia. Kidney Int. 2006 Apr; 69(7):1120-3. Verkman AS. PMID: 16508658.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    311. Cardiac aquaporin expression in humans, rats, and mice. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H705-13. Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, Winlaw DS. PMID: 16582023.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    312. Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis. Transfus Clin Biol. 2006 Mar-Apr; 13(1-2):117-22. Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman AS, Cartron JP. PMID: 16574458.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    313. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab. 2006 Dec; 26(12):1527-37. Bloch O, Auguste KI, Manley GT, Verkman AS. PMID: 16552421.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    314. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochim Biophys Acta. 2006 Aug; 1758(8):1085-93. Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC. PMID: 16564496.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    315. Fluorescence correlation spectroscopy simulations of photophysical phenomena and molecular interactions: a molecular dynamics/monte carlo approach. J Phys Chem B. 2006 Feb 02; 110(4):1896-906. Dix JA, Hom EF, Verkman AS. PMID: 16471761; PMCID: PMC3129548.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    316. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1022-8. Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT. PMID: 16476579.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    317. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F465-72. Yang B, Zhao D, Qian L, Verkman AS. PMID: 16434568.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    318. Increased seizure duration in mice lacking aquaporin-4 water channels. Acta Neurochir Suppl. 2006; 96:389-92. Binder DK, Yao X, Verkman AS, Manley GT. PMID: 16671491.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    319. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Curr Pharm Des. 2006; 12(18):2235-47. Verkman AS, Lukacs GL, Galietta LJ. PMID: 16787252.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    320. Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):306-16. Levin MH, Kim JK, Hu J, Verkman AS. PMID: 16384978.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    321. Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule. J Am Soc Nephrol. 2006 Jan; 17(1):39-45. Hara-Chikuma M, Verkman AS. PMID: 16319186.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    322. Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB J. 2006 Jan; 20(1):130-2. Sonawane ND, Hu J, Muanprasat C, Verkman AS. PMID: 16317066.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    323. Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Exp Eye Res. 2006 May; 82(5):879-84. Ruiz-Ederra J, Verkman AS. PMID: 16310189.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    324. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005 Dec 15; 118(Pt 24):5691-8. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS. PMID: 16303850.
      View in: PubMed   Mentions: 213     Fields:    Translation:AnimalsCells
    325. Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett. 2006 Feb; 16(3):537-40. Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ. PMID: 16288863.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    326. K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods. 2005 Nov; 2(11):825-7. Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS. PMID: 16278651.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    327. Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C741-9. Song Y, Salinas D, Nielson DW, Verkman AS. PMID: 16207791.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    328. Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice. Biol Cell. 2005 Oct; 97(10):765-78. Kim SW, Gresz V, Rojek A, Wang W, Verkman AS, Frøkiaer J, Nielsen S. PMID: 15898956.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    329. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem. 2005 Oct; 95(1):254-62. Bloch O, Papadopoulos MC, Manley GT, Verkman AS. PMID: 16181429.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    330. Extracellular space diffusion in central nervous system: anisotropic diffusion measured by elliptical surface photobleaching. Biophys J. 2005 Nov; 89(5):3660-8. Papadopoulos MC, Kim JK, Verkman AS. PMID: 16143636; PMCID: PMC1366858.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    331. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. PMID: 16143588.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    332. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol. 2005 Sep; 25(17):7770-9. Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K. PMID: 16107722; PMCID: PMC1190286.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    333. Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. J Clin Invest. 2005 Sep; 115(9):2564-71. Pedemonte N, Lukacs GL, Du K, Caci E, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 16127463; PMCID: PMC1190372.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansAnimalsCells
    334. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med. 2005 Aug 15; 202(4):473-7. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. PMID: 16087714; PMCID: PMC2212860.
      View in: PubMed   Mentions: 739     Fields:    Translation:HumansAnimalsCells
    335. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 2005 Aug 01; 118(Pt 15):3225-32. Verkman AS. PMID: 16079275.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    336. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005 Dec; 289(6):F1195-200. Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S. PMID: 15998844.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    337. Aquaporin-3 functions as a glycerol transporter in mammalian skin. Biol Cell. 2005 Jul; 97(7):479-86. Hara-Chikuma M, Verkman AS. PMID: 15966863.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    338. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. Biochem J. 2005 May 01; 387(Pt 3):911-9. Schulz BL, Sloane AJ, Robinson LJ, Sebastian LT, Glanville AR, Song Y, Verkman AS, Harry JL, Packer NH, Karlsson NG. PMID: 15563276; PMCID: PMC1135025.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    339. Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochem Biophys Res Commun. 2005 Apr 15; 329(3):941-6. Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS. PMID: 15752747.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    340. Noninvasive early detection of brain edema in mice by near-infrared light scattering. J Neurosci Res. 2005 Apr 15; 80(2):293-9. Thiagarajah JR, Papadopoulos MC, Verkman AS. PMID: 15765520.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    341. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005 Apr 07; 434(7034):786-92. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. PMID: 15815633.
      View in: PubMed   Mentions: 310     Fields:    Translation:AnimalsCells
    342. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv Drug Deliv Rev. 2005 Apr 05; 57(5):755-67. Lechardeur D, Verkman AS, Lukacs GL. PMID: 15757759.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    343. New drug targets for cholera therapy. Trends Pharmacol Sci. 2005 Apr; 26(4):172-5. Thiagarajah JR, Verkman AS. PMID: 15808339.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    344. CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1428-34. Levin MH, Verkman AS. PMID: 15790911.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    345. Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem. 2005 Apr 22; 280(16):15493-6. Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS. PMID: 15746100.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    346. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May; 67(5):1797-807. Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS. PMID: 15722457.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    347. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem. 2005 Apr 08; 280(14):13906-12. Papadopoulos MC, Verkman AS. PMID: 15695511.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    348. Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol. 2005 May; 288(5):C1161-70. Yang B, Song Y, Zhao D, Verkman AS. PMID: 15647389.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    349. Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery. J Biol Chem. 2005 Mar 04; 280(9):7823-8. Dauty E, Verkman AS. PMID: 15632160.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    350. In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents. J Pharm Sci. 2005 Jan; 94(1):134-43. Sonawane ND, Muanprasat C, Nagatani R, Song Y, Verkman AS. PMID: 15761937.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    351. Novel roles of aquaporins revealed by phenotype analysis of knockout mice. Rev Physiol Biochem Pharmacol. 2005; 155:31-55. Verkman AS. PMID: 16091927.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    352. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. PMID: 15596485.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    353. Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching. FASEB J. 2005 Mar; 19(3):425-7. Papadopoulos MC, Binder DK, Verkman AS. PMID: 15596484.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    354. Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4477-83. Da T, Verkman AS. PMID: 15557457.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    355. Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4423-32. Levin MH, Verkman AS. PMID: 15557451.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    356. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J. 2005 Jan; 19(1):76-8. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT. PMID: 15533949.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    357. ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem. 2005 Jan 14; 280(2):1241-7. Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS. PMID: 15504734.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    358. In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci. 2004 Sep 15; 24(37):8049-56. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS. PMID: 15371505; PMCID: PMC6729785.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    359. Drug discovery and epithelial physiology. Curr Opin Nephrol Hypertens. 2004 Sep; 13(5):563-8. Verkman AS. PMID: 15300164.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    360. Molecular crowding reduces to a similar extent the diffusion of small solutes and macromolecules: measurement by fluorescence correlation spectroscopy. J Mol Recognit. 2004 Sep-Oct; 17(5):441-7. Dauty E, Verkman AS. PMID: 15362103.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    361. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug; 124(2):125-37. Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. PMID: 15277574; PMCID: PMC2229623.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    362. Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models. J Biol Chem. 2004 Sep 24; 279(39):40629-33. Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS. PMID: 15280357.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    363. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L936-43. Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS. PMID: 15246976.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    364. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004 Aug; 18(11):1291-3. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. PMID: 15208268.
      View in: PubMed   Mentions: 288     Fields:    Translation:AnimalsCells
    365. Fluid transport across cultured layers of corneal endothelium from aquaporin-1 null mice. Exp Eye Res. 2004 Apr; 78(4):791-8. Kuang K, Yiming M, Wen Q, Li Y, Ma L, Iserovich P, Verkman AS, Fischbarg J. PMID: 15037113.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    366. A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J. 2004 May; 18(7):875-7. Thiagarajah JR, Song Y, Haggie PM, Verkman AS. PMID: 15001557.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    367. Drug discovery in academia. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C465-74. Verkman AS. PMID: 14761879.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    368. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport. 2004 Feb 09; 15(2):259-62. Binder DK, Oshio K, Ma T, Verkman AS, Manley GT. PMID: 15076748.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    369. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology. 2004 Feb; 126(2):511-9. Thiagarajah JR, Broadbent T, Hsieh E, Verkman AS. PMID: 14762788.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    370. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30; 558(1-3):52-6. Taddei A, Folli C, Zegarra-Moran O, Fanen P, Verkman AS, Galietta LJ. PMID: 14759515.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    371. New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience. 2004; 129(4):983-91. Manley GT, Binder DK, Papadopoulos MC, Verkman AS. PMID: 15561413.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    372. Molecular mechanisms of brain tumor edema. Neuroscience. 2004; 129(4):1011-20. Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. PMID: 15561416.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    373. Expression of aquaporin water channels in mouse spinal cord. Neuroscience. 2004; 127(3):685-93. Oshio K, Binder DK, Yang B, Schecter S, Verkman AS, Manley GT. PMID: 15283967.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    374. CFTR pharmacology and its role in intestinal fluid secretion. Curr Opin Pharmacol. 2003 Dec; 3(6):594-9. Thiagarajah JR, Verkman AS. PMID: 14644010.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    375. Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif. J Biol Chem. 2004 Feb 13; 279(7):5494-500. Haggie PM, Stanton BA, Verkman AS. PMID: 14660592.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    376. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C426-32. Solenov E, Watanabe H, Manley GT, Verkman AS. PMID: 14576087.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    377. Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. J Gen Physiol. 2003 Nov; 122(5):511-9. Song Y, Thiagarajah J, Verkman AS. PMID: 14557401; PMCID: PMC2229580.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    378. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 01; 11(18):4113-20. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. PMID: 12927873.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    379. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003 Nov 07; 278(45):44826-31. Sonawane ND, Szoka FC, Verkman AS. PMID: 12944394.
      View in: PubMed   Mentions: 262     Fields:    Translation:AnimalsCells
    380. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett. 2003 Aug 04; 13(15):2509-12. Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. PMID: 12852954.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    381. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem. 2003 Sep 12; 278(37):35079-85. Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. PMID: 12832418.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    382. Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7360-5. Hara M, Verkman AS. PMID: 12771381; PMCID: PMC165880.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    383. Increased expression of H+-ATPase in inner medullary collecting duct of aquaporin-1-deficient mice. Am J Physiol Renal Physiol. 2003 Sep; 285(3):F550-7. Kim YH, Kim J, Verkman AS, Madsen KM. PMID: 12759225.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    384. Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands. J Cell Biol. 2003 Mar 31; 160(7):1129-38. Sonawane ND, Verkman AS. PMID: 12668661; PMCID: PMC2172765.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    385. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L180-8. Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. PMID: 12651632.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    386. Role of aquaporin water channels in eye function. Exp Eye Res. 2003 Feb; 76(2):137-43. Verkman AS. PMID: 12565800.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    387. Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema. Acta Neurochir Suppl. 2003; 86:499-502. Oshio K, Binder DK, Bollen A, Verkman AS, Berger MS, Manley GT. PMID: 14753494.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    388. Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production. Acta Neurochir Suppl. 2003; 86:525-8. Oshio K, Song Y, Verkman AS, Manley GT. PMID: 14753499.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    389. Diffusion in cells measured by fluorescence recovery after photobleaching. Methods Enzymol. 2003; 360:635-48. Verkman AS. PMID: 12622172.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    390. Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C2-15. Verkman AS, Song Y, Thiagarajah JR. PMID: 12475759.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimals
    391. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec; 110(11):1651-8. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. PMID: 12464670; PMCID: PMC151633.
      View in: PubMed   Mentions: 310     Fields:    Translation:HumansAnimalsCells
    392. Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways. J Appl Physiol (1985). 2002 Dec; 93(6):2199-206. Borok Z, Verkman AS. PMID: 12433939.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    393. Expression and localization of aquaporin 1 and 3 in human fetal membranes. Am J Obstet Gynecol. 2002 Oct; 187(4):902-7. Mann SE, Ricke EA, Yang BA, Verkman AS, Taylor RN. PMID: 12388974.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    394. Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G739-46. Mennone A, Verkman AS, Boyer JL. PMID: 12181190.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    395. Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J Appl Physiol (1985). 2003 Jan; 94(1):343-52. Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS. PMID: 12391048.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    396. Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex. J Biol Chem. 2002 Oct 25; 277(43):40782-8. Haggie PM, Verkman AS. PMID: 12198136.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    397. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem. 2002 Oct 04; 277(40):37235-41. Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS. PMID: 12161441.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    398. Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J Biol Chem. 2002 Sep 27; 277(39):36782-6. Yang B, Verkman AS. PMID: 12133842.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    399. Analysis of coupled bimolecular reaction kinetics and diffusion by two-color fluorescence correlation spectroscopy: enhanced resolution of kinetics by resonance energy transfer. Biophys J. 2002 Jul; 83(1):533-46. Hom EF, Verkman AS. PMID: 12080140; PMCID: PMC1302167.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    400. Does aquaporin-1 pass gas? An opposing view. J Physiol. 2002 Jul 01; 542(Pt 1):31. Verkman AS. PMID: 12096046; PMCID: PMC2290386.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    401. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. J Physiol. 2002 Jul 01; 542(Pt 1):63-9. Fang X, Yang B, Matthay MA, Verkman AS. PMID: 12096051; PMCID: PMC2290384.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    402. Aquaporin water channels and endothelial cell function. J Anat. 2002 Jun; 200(6):617-27. Verkman AS. PMID: 12162729; PMCID: PMC1570747.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    403. Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production. J Gen Physiol. 2002 Jun; 119(6):561-9. Zhang D, Vetrivel L, Verkman AS. PMID: 12034763; PMCID: PMC2233864.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    404. Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice. J Physiol. 2002 Jun 01; 541(Pt 2):561-8. Song Y, Sonawane N, Verkman AS. PMID: 12042359; PMCID: PMC2290337.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    405. Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J Biol Chem. 2002 May 24; 277(21):19139-44. Thiagarajah JR, Verkman AS. PMID: 11891232.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    406. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J Biol Chem. 2002 May 10; 277(19):17147-53. Ma T, Hara M, Sougrat R, Verbavatz JM, Verkman AS. PMID: 11880378.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    407. Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. J Biol Chem. 2002 May 10; 277(19):16419-25. Haggie PM, Stanton BA, Verkman AS. PMID: 11877404.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    408. Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):573-9. Li J, Patil RV, Verkman AS. PMID: 11818406.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    409. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol. 2002 Feb; 119(2):199-207. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. PMID: 11815669; PMCID: PMC2233804.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    410. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J Neurosci Methods. 2002 Jan 15; 113(1):85-90. Solenov EI, Vetrivel L, Oshio K, Manley GT, Verkman AS. PMID: 11741725.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    411. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem. 2002 Mar 22; 277(12):10633-7. Yang B, Bankir L, Gillespie A, Epstein CJ, Verkman AS. PMID: 11792714.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    412. Physiological importance of aquaporin water channels. Ann Med. 2002; 34(3):192-200. Verkman AS. PMID: 12173689.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    413. Fluorescent indicator methods to assay functional CFTR expression in cells. Methods Mol Med. 2002; 70:187-96. Verkman AS, Jayaraman S. PMID: 11917522.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    414. Solute and macromolecule diffusion in cellular aqueous compartments. Trends Biochem Sci. 2002 Jan; 27(1):27-33. Verkman AS. PMID: 11796221.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    415. Renal concentrating and diluting function in deficiency of specific aquaporin genes. Exp Nephrol. 2002; 10(4):235-40. Verkman AS. PMID: 12097826.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    416. Aquaporin gene delivery to kidney. Kidney Int. 2002 Jan; 61(1 Suppl):S120-4. Verkman AS, Yang B. PMID: 11841625.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    417. Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. J Biol Chem. 2002 Feb 15; 277(7):5506-13. Sonawane ND, Thiagarajah JR, Verkman AS. PMID: 11741919.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    418. In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1898-903. Thiagarajah JR, Jayaraman S, Naftalin RJ, Verkman AS. PMID: 11698248.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    419. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):14132-7. Zhou Q, Clarke L, Nie R, Carnes K, Lai LW, Lien YH, Verkman A, Lubahn D, Fisher JS, Katzenellenbogen BS, Hess RA. PMID: 11698654; PMCID: PMC61180.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    420. Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1504-11. Jayaraman S, Song Y, Verkman AS. PMID: 11600413.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    421. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1734-42. Galietta LV, Jayaraman S, Verkman AS. PMID: 11600438.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    422. Applications of aquaporin inhibitors. Drug News Perspect. 2001 Sep; 14(7):412-20. Verkman AS. PMID: 12813584.
      View in: PubMed   Mentions: 9     Fields:    
    423. Aquaporin-4 expression in adult and developing mouse and rat kidney. J Am Soc Nephrol. 2001 Sep; 12(9):1795-1804. Kim YH, Earm JH, Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J. PMID: 11518772.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    424. Lung disease in cystic fibrosis: is airway surface liquid composition abnormal? Am J Physiol Lung Cell Mol Physiol. 2001 Aug; 281(2):L306-8. Verkman AS. PMID: 11435202.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    425. HCO3- transport in relation to mucus secretion from submucosal glands. JOP. 2001 Jul; 2(4 Suppl):280-4. Joo NS, Krouse ME, Wu JV, Saenz Y, Jayaraman S, Verkman AS, Wine JJ. PMID: 11875272.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    426. Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na(+)] and pH but elevated viscosity. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):8119-23. Jayaraman S, Joo NS, Reitz B, Wine JJ, Verkman AS. PMID: 11427704; PMCID: PMC35477.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    427. Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Lett. 2001 Jun 22; 499(3):220-4. Galietta LJ, Haggie PM, Verkman AS. PMID: 11423120.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    428. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol. 2001 Jun; 117(6):573-82. Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS. PMID: 11382807; PMCID: PMC2232398.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    429. Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes. J Gen Physiol. 2001 May; 117(5):423-30. Jayaraman S, Song Y, Verkman AS. PMID: 11331352; PMCID: PMC2233658.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    430. Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. J Biol Chem. 2001 Jun 15; 276(24):21331-6. Levin MH, Haggie PM, Vetrivel L, Verkman AS. PMID: 11297561.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    431. Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. J Biol Chem. 2001 Jun 08; 276(23):19723-8. Galietta LJ, Springsteel MF, Eda M, Niedzinski EJ, By K, Haddadin MJ, Kurth MJ, Nantz MH, Verkman AS. PMID: 11262417.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    432. Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH. J Clin Invest. 2001 Feb; 107(3):317-24. Jayaraman S, Song Y, Vetrivel L, Shankar L, Verkman AS. PMID: 11160155; PMCID: PMC199195.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    433. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001 Jan 05; 276(1):624-8. Yang B, Ma T, Verkman AS. PMID: 11035042.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    434. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C126-34. Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS. PMID: 11121384; PMCID: PMC3491804.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    435. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50. Song Y, Yang B, Matthay MA, Ma T, Verkman AS. PMID: 11078688.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    436. Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. J Biol Chem. 2000 Nov 03; 275(44):34157-65. Foster W, Helm A, Turnbull I, Gulati H, Yang B, Verkman AS, Skach WR. PMID: 10944517.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    437. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001 Jan 26; 276(4):2775-9. Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. PMID: 11035038.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    438. Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Mol Biol Cell. 2000 Sep; 11(9):2973-85. Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS, Skach WR. PMID: 10982394; PMCID: PMC14969.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    439. Physiological importance of aquaporins: lessons from knockout mice. Curr Opin Nephrol Hypertens. 2000 Sep; 9(5):517-22. Verkman AS. PMID: 10990371.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    440. Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G448-53. Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA. PMID: 10915655; PMCID: PMC3495182.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    441. Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G463-70. Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA. PMID: 10915657; PMCID: PMC3495185.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    442. Mesoscopic surfactant organization and membrane protein crystallization. Protein Sci. 2000 Jul; 9(7):1407-9. Wiener MC, Verkman AS, Stroud RM, van Hoek AN. PMID: 10933509; PMCID: PMC2144676.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    443. Analysis of organ physiology in transgenic mice. Am J Physiol Cell Physiol. 2000 Jul; 279(1):C1-C18. Rao S, Verkman AS. PMID: 10898711.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    444. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000 Jun 15; 525 Pt 3:771-9. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS. PMID: 10856128; PMCID: PMC2269974.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    445. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000 Jun; 278(6):C1108-15. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS. PMID: 10837338.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells