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Alan Verkman, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Phone415-476-8530
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    M.I.T.S.B., S.B.Physics, Biology
    Harvard UniversityM.A., Ph.D.Physics
    Harvard Medical School / HSTM.D.
    Brigham & Womens HospitalResidency Medicine
    University of California, San FranciscoFellowship Nephrology

    Collapse Research 
    Collapse Research Activities and Funding
    Urea transport inhibitors as a new class of diuretics
    NIH/NIDDK R01DK101373Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    CFTR inhibitors for therapy of polycystic kidney disease
    NIH/NIDDK RC1DK086125Sep 25, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Novel Small-Molecule Therapies for CF
    NIH/NIDDK P30DK072517Sep 15, 2005 - May 31, 2020
    Role: Principal Investigator
    Role of airway submucosal glands in CF lung disease
    NIH/NHLBI R01HL073856Sep 1, 2003 - Aug 31, 2013
    Role: Principal Investigator
    Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New Therapies
    NIH/NEI R01EY013574Jul 1, 2001 - Apr 30, 2023
    Role: Principal Investigator
    Physiology and Molecular Biology of Lung Water Transport
    NIH/NHLBI R01HL059198Sep 1, 1998 - Jul 31, 2009
    Role: Principal Investigator
    ALTERATIONS IN AIRWAY SURFACE LIQUID IN CYSTIC FIBROSIS
    NIH P50HL060288Sep 1, 1998 - Aug 31, 2003
    Role: Co-Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH/NIBIB R37EB000415Jul 1, 1997 - Mar 31, 2017
    Role: Principal Investigator
    Application of Novel Optical Methods to Cell Dynamics
    NIH/NIBIB R01EB000415Jul 1, 1997 - Mar 31, 2007
    Role: Principal Investigator
    MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    NIH/FIC R03TW000704Sep 1, 1996 - Aug 31, 2000
    Role: Principal Investigator
    APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    NIH/NIDDK R01DK043840Feb 1, 1993 - Jan 31, 2002
    Role: Principal Investigator
    DEVELOPMENT OF CHLORIDE-SENSITIVE FLUORESCENT INDICATORS
    NIH/NIDDK R01DK039354Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    Mechanisms of water transport in renal epithelia
    NIH/NIDDK R01DK035124Jan 1, 1986 - Jun 30, 2015
    Role: Principal Investigator
    MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    NIH/NIDDK R37DK035124Jan 1, 1986 - May 31, 2010
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CF pathogenesis mechanisms and therapies
    Cystic Fibrosis Foundation
    Role: PI
    Neuromyelitis Optica: Disease Mechanisms & New Therapies
    Guthy-Jackson Charitable Foundation
    Role: PI

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS. Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. J Neuropathol Exp Neurol. 2019 Jan 01; 78(1):47-56. PMID: 30500945.
      View in: PubMed
    2. Duan T, Smith AJ, Verkman AS. Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2018 Oct 22; 15(1):294. PMID: 30348195.
      View in: PubMed
    3. Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight. 2018 Jul 26; 3(14). PMID: 30046015.
      View in: PubMed
    4. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. J Cyst Fibros. 2018 Jun 11. PMID: 29903467.
      View in: PubMed
    5. Jin BJ, Lee S, Verkman AS. Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Anal Chem. 2018 May 30. PMID: 29779372.
      View in: PubMed
    6. Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW. Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis. JCI Insight. 2018 May 17; 3(10). PMID: 29769447.
      View in: PubMed
    7. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 Apr 12; 61(7):3209-3217. PMID: 29589443.
      View in: PubMed
    8. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov. 2018 Mar 01; 2472555218763310. PMID: 29533733.
      View in: PubMed
    9. Verkman AS, Yao X, Smith AJ. The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. J Cell Mol Med. 2018 Mar; 22(3):2039-2040. PMID: 29363875.
      View in: PubMed
    10. Smith AJ, Verkman AS. The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB J. 2018 Feb; 32(2):543-551. PMID: 29101220.
      View in: PubMed
    11. Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert Opin Ther Targets. 2017 12; 21(12):1161-1170. PMID: 29072508.
      View in: PubMed
    12. Felix CM, Lee S, Levin MH, Verkman AS. Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4506-4513. PMID: 28873176.
      View in: PubMed
    13. Smith AJ, Yao X, Dix JA, Jin BJ, Verkman AS. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. Elife. 2017 Aug 21; 6. PMID: 28826498.
      View in: PubMed
    14. Yao X, Verkman AS. Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 07 27; 5(1):57. PMID: 28750658.
      View in: PubMed
    15. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. Mechanisms of Autoantibody-Induced Pathology. Front Immunol. 2017; 8:603. PMID: 28620373.
      View in: PubMed
    16. Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta Neuropathol. 2017 Jul; 134(1):35-44. PMID: 28567523.
      View in: PubMed
    17. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 Jun 08; 60(11):4626-4635. PMID: 28493701.
      View in: PubMed
    18. Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochim Biophys Acta. 2017 08; 1859(8):1326-1334. PMID: 28477975.
      View in: PubMed
    19. Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B. Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochim Biophys Acta. 2017 Jun; 1863(6):1231-1241. PMID: 28344130.
      View in: PubMed
    20. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 Mar 23; 60(6):2401-2410. PMID: 28230981.
      View in: PubMed
    21. Jin BJ, Verkman AS. Microfluidic platform for rapid measurement of transepithelial water transport. Lab Chip. 2017 02 28; 17(5):887-895. PMID: 28184395.
      View in: PubMed
    22. Yao X, Verkman AS. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 Feb 17; 5(1):15. PMID: 28212662.
      View in: PubMed
    23. Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. J Med Chem. 2017 Feb 09; 60(3):1210-1218. PMID: 28099811.
      View in: PubMed
    24. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. PMID: 28049834.
      View in: PubMed
    25. Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS. Aquaporin-Targeted Therapeutics: State-of-the-Field. Adv Exp Med Biol. 2017; 969:239-250. PMID: 28258578.
      View in: PubMed
    26. Verkman AS, Tradtrantip L, Smith AJ, Yao X. Aquaporin Water Channels and Hydrocephalus. Pediatr Neurosurg. 2017; 52(6):409-416. PMID: 27978530.
      View in: PubMed
    27. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14781-14786. PMID: 27940915.
      View in: PubMed
    28. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. J Biol Chem. 2017 01 20; 292(3):771-785. PMID: 27895116.
      View in: PubMed
    29. Jin BJ, Smith AJ, Verkman AS. Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. J Gen Physiol. 2016 Dec; 148(6):489-501. PMID: 27836940.
      View in: PubMed
    30. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 02; 31(2):751-760. PMID: 27871064.
      View in: PubMed
    31. Felix CM, Levin MH, Verkman AS. Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. J Neuroinflammation. 2016 10 20; 13(1):275. PMID: 27765056.
      View in: PubMed
    32. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4. PMID: 27815136.
      View in: PubMed
    33. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. PMID: 27570835.
      View in: PubMed
    34. Tradtrantip L, Verkman AS. Aquaporin gene therapy for disorders of cholestasis? Hepatology. 2016 08; 64(2):344-6. PMID: 27115396.
      View in: PubMed
    35. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Sci Rep. 2016 05 11; 6:25781. PMID: 27165276.
      View in: PubMed
    36. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714. PMID: 27153921.
      View in: PubMed
    37. Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. J Enzyme Inhib Med Chem. 2016 Dec; 31(6):1362-8. PMID: 26796863; PMCID: PMC4958041 [Available on 07/22/17].
    38. Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. J Cereb Blood Flow Metab. 2017 Jan; 37(1):277-290. PMID: 26767580.
      View in: PubMed
    39. Smith AJ, Verkman AS. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophys J. 2015 Dec 15; 109(12):2511-22. PMID: 26682810; PMCID: PMC4699884 [Available on 12/15/16].
    40. Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. J Cyst Fibros. 2015 Nov; 14(6):700-5. PMID: 26474804; PMCID: PMC4786369.
    41. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci. 2015 Sep 30; 35(39):13525-37. PMID: 26424896; PMCID: PMC4588615.
    42. Jin BJ, Esteva-Font C, Verkman AS. Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab Chip. 2015 Aug 21; 15(16):3380-90. PMID: 26159099; PMCID: PMC4706553.
    43. Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):446-57. PMID: 26122478; PMCID: PMC4786374.
    44. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. J Neurotrauma. 2015 Oct 01; 32(19):1458-64. PMID: 25790314; PMCID: PMC4589265 [Available on 10/01/16].
    45. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015 Aug; 88(2):311-20. PMID: 25993324.
      View in: PubMed
    46. Smith AJ, Jin BJ, Verkman AS. Muddying the water in brain edema? Trends Neurosci. 2015 Jun; 38(6):331-2. PMID: 25980601; PMCID: PMC4739497.
    47. Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. J Biol Chem. 2015 May 08; 290(19):12123-34. PMID: 25792738; PMCID: PMC4424347.
    48. Esteva-Font C, Anderson MO, Verkman AS. Urea transporter proteins as targets for small-molecule diuretics. Nat Rev Nephrol. 2015 Feb; 11(2):113-23. PMID: 25488859; PMCID: PMC4743986.
    49. Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman AS, Bollen AW, Ralph JW. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle Nerve. 2014 Nov; 50(5):859-62. PMID: 24862586; PMCID: PMC4306419.
    50. Papadopoulos MC, Bennett JL, Verkman AS. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nat Rev Neurol. 2014 Sep; 10(9):493-506. PMID: 25112508; PMCID: PMC4229040.
    51. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Some gating potentiators, including VX-770, diminish ?F508-CFTR functional expression. Sci Transl Med. 2014 Jul 23; 6(246):246ra97. PMID: 25101887; PMCID: PMC4467693.
    52. Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS. Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids. Biomicrofluidics. 2014 Mar; 8(2):024106. PMID: 24738013; PMCID: PMC3976466.
    53. Verkman AS, Anderson MO, Papadopoulos MC. Aquaporins: important but elusive drug targets. Nat Rev Drug Discov. 2014 Apr; 13(4):259-77. PMID: 24625825; PMCID: PMC4067137.
    54. Tradtrantip L, Ko EA, Verkman AS. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2674. PMID: 24551253; PMCID: PMC3923670.
    55. Smith AJ, Jin BJ, Ratelade J, Verkman AS. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. J Cell Biol. 2014 Feb 17; 204(4):559-73. PMID: 24515349; PMCID: PMC3926963.
    56. Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. J Neuroinflammation. 2014 Jan 27; 11:16. PMID: 24468108; PMCID: PMC3909205.
    57. Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Small-molecule inhibitors of urea transporters. Subcell Biochem. 2014; 73:165-77. PMID: 25298345; PMCID: PMC4306426.
    58. Esteva-Font C, Jin BJ, Verkman AS. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J. 2014 Mar; 28(3):1446-53. PMID: 24334548; PMCID: PMC3929666.
    59. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB J. 2014 Feb; 28(2):791-801. PMID: 24200884; PMCID: PMC3898646.
    60. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB J. 2014 Feb; 28(2):705-14. PMID: 24186965; PMCID: PMC3898642.
    61. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clin Gastroenterol Hepatol. 2014 Jan; 12(1):27-31. PMID: 24184676; PMCID: PMC3926754.
    62. Jin BJ, Ko EA, Namkung W, Verkman AS. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds. Lab Chip. 2013 Oct 07; 13(19):3862-7. PMID: 23907501; PMCID: PMC3904508.
    63. Rowe SM, Verkman AS. Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harb Perspect Med. 2013 Jul 01; 3(7). PMID: 23818513; PMCID: PMC3685879.
    64. Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Mechanism-based corrector combination restores ?F508-CFTR folding and function. Nat Chem Biol. 2013 Jul; 9(7):444-54. PMID: 23666117; PMCID: PMC3840170.
    65. Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013 Apr; 14(4):265-77. PMID: 23481483; PMCID: PMC3732112.
    66. Verkman AS. Aquaporins. Curr Biol. 2013 Jan 21; 23(2):R52-5. PMID: 23347934; PMCID: PMC3590904.
    67. Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. CFTR inhibitors. Curr Pharm Des. 2013; 19(19):3529-41. PMID: 23331030; PMCID: PMC4012685.
    68. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. J Biol Chem. 2012 Dec 21; 287(52):43630-8. PMID: 23115232.
      View in: PubMed
    69. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med. 2012 Sep 24; 209(10):1743-52. PMID: 22927550; PMCID: PMC3457725.
    70. Verkman AS. Aquaporins in clinical medicine. Annu Rev Med. 2012; 63:303-16. PMID: 22248325; PMCID: PMC3319404.
    71. Verkman AS. Aquaporins at a glance. J Cell Sci. 2011 Jul 01; 124(Pt 13):2107-12. PMID: 21670197.
      View in: PubMed
    72. Verkman AS, Ratelade J, Rossi A, Zhang H, Tradtrantip L. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta Pharmacol Sin. 2011 Jun; 32(6):702-10. PMID: 21552296; PMCID: PMC3601948.
    73. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci. 2011 Apr 27; 31(17):6392-7. PMID: 21525279; PMCID: PMC3107562.
    74. Carpenter RD, Verkman AS. Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing. European J Org Chem. 2011 Mar 01; 2011(7):1242-1248. PMID: 23914138.
      View in: PubMed
    75. Nakahigashi K, Kabashima K, Ikoma A, Verkman AS, Miyachi Y, Hara-Chikuma M. Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. J Invest Dermatol. 2011 Apr; 131(4):865-73. PMID: 21191421.
      View in: PubMed
    76. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010 Jun; 67(6):794-801. PMID: 20517941.
      View in: PubMed
    77. Verkman AS. Aquaporins: translating bench research to human disease. J Exp Biol. 2009 Jun; 212(Pt 11):1707-15. PMID: 19448080; PMCID: PMC2683014.
    78. Crane JM, Verkman AS. Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging. J Cell Sci. 2009 Mar 15; 122(Pt 6):813-21. PMID: 19240114; PMCID: PMC2714425.
    79. Verkman AS. Knock-out models reveal new aquaporin functions. Handb Exp Pharmacol. 2009; (190):359-81. PMID: 19096787; PMCID: PMC3595129.
    80. Verkman AS, Ruiz-Ederra J, Levin MH. Functions of aquaporins in the eye. Prog Retin Eye Res. 2008 Jul; 27(4):420-33. PMID: 18501660; PMCID: PMC3319433.
    81. Verkman AS. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert Rev Mol Med. 2008 May 16; 10:e13. PMID: 18482462; PMCID: PMC3601943.
    82. Verkman AS. Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Semin Nephrol. 2008 May; 28(3):217-26. PMID: 18519083; PMCID: PMC2692584.
    83. Verkman AS, Hara-Chikuma M, Papadopoulos MC. Aquaporins--new players in cancer biology. J Mol Med (Berl). 2008 May; 86(5):523-9. PMID: 18311471; PMCID: PMC3590015.
    84. Verkman AS, Galietta LJ. Chloride channels as drug targets. Nat Rev Drug Discov. 2009 Feb; 8(2):153-71. PMID: 19153558; PMCID: PMC3601949.
    85. Papadopoulos MC, Verkman AS. Aquaporin-4 and brain edema. Pediatr Nephrol. 2007 Jun; 22(6):778-84. PMID: 17347837.
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    86. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol. 2007 Feb; 292(2):L383-95. PMID: 16920886.
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    87. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia. 2006 Apr 15; 53(6):631-6. PMID: 16470808.
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    88. Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol. 2005 Sep; 25(17):7770-9. PMID: 16107722; PMCID: PMC1190286.
    89. Schulz BL, Sloane AJ, Robinson LJ, Sebastian LT, Glanville AR, Song Y, Verkman AS, Harry JL, Packer NH, Karlsson NG. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. Biochem J. 2005 May 01; 387(Pt 3):911-9. PMID: 15563276; PMCID: PMC1135025.
    90. Verkman AS. Drug discovery and epithelial physiology. Curr Opin Nephrol Hypertens. 2004 Sep; 13(5):563-8. PMID: 15300164.
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    91. Thiagarajah JR, Broadbent T, Hsieh E, Verkman AS. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology. 2004 Feb; 126(2):511-9. PMID: 14762788.
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    92. Verkman AS. Diffusion in cells measured by fluorescence recovery after photobleaching. Methods Enzymol. 2003; 360:635-48. PMID: 12622172.
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    93. Mann SE, Ricke EA, Yang BA, Verkman AS, Taylor RN. Expression and localization of aquaporin 1 and 3 in human fetal membranes. Am J Obstet Gynecol. 2002 Oct; 187(4):902-7. PMID: 12388974.
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    94. Mennone A, Verkman AS, Boyer JL. Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G739-46. PMID: 12181190.
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    95. Verkman AS, Jayaraman S. Fluorescent indicator methods to assay functional CFTR expression in cells. Methods Mol Med. 2002; 70:187-96. PMID: 11917522.
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    96. Verkman AS. Physiological importance of aquaporin water channels. Ann Med. 2002; 34(3):192-200. PMID: 12173689.
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    97. Verkman AS, Yang B. Aquaporin gene delivery to kidney. Kidney Int. 2002 Jan; 61(1 Suppl):S120-4. PMID: 11841625.
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    98. Verkman AS. Solute and macromolecule diffusion in cellular aqueous compartments. Trends Biochem Sci. 2002 Jan; 27(1):27-33. PMID: 11796221.
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