Trevor Fidler, PhD

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #452J
San Francisco CA 94158
Phone415-514-8082
Pronounshe/him/his
ORCID ORCID Icon0000-0002-0758-9984 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia University, New York, NYPostdoctoral Fellow2023Molecular Medicine
    University of Utah, Salt Lake City, UTPhD2016Pharmacology & Toxicology
    New Mexico State University, Las Cruces, NMBS2010Biochemistry

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Atherogenesis in Clonal Hematopoiesis
    NIH/NHLBI R00HL157649Aug 1, 2023 - Jul 30, 2026
    Role: PI

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    Collapse Featured Publications

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis. Nat Cardiovasc Res. 2024 Jan; 3(1):60-75. Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR. PMID: 38362011; PMCID: PMC10868728.
      View in: PubMed   Mentions:
    2. Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. J Clin Invest. 2023 09 15; 133(18). Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P. PMID: 37498674; PMCID: PMC10503804.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    3. Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis. Diabetes. 2023 07 01; 72(7):999-1011. Hsu CC, Fidler TP, Kanter JE, Kothari V, Kramer F, Tang J, Tall AR, Bornfeldt KE. PMID: 37083999; PMCID: PMC10281813.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    4. Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging. Arterioscler Thromb Vasc Biol. 2023 01; 43(1):79-91. Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S. PMID: 36325902; PMCID: PMC9780178.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis. J Clin Invest. 2022 07 01; 132(13). Liu W, Östberg N, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, Hou X, Xiao T, Fidler TP, Abramowicz S, Yang YG, Soehnlein O, Tall AR, Wang N. PMID: 35587375; PMCID: PMC9246386.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    6. Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein. Sci Rep. 2021 12 24; 11(1):24432. Yalcinkaya M, Liu W, Islam MN, Kotini AG, Gusarova GA, Fidler TP, Papapetrou EP, Bhattacharya J, Wang N, Tall AR. PMID: 34952919; PMCID: PMC8709866.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    7. Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Circulation. 2021 12 14; 144(24):1940-1954. Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR. PMID: 34846914; PMCID: PMC8663540.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    8. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature. 2021 04; 592(7853):296-301. Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR. PMID: 33731931; PMCID: PMC8038646.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    9. Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice. Cardiovasc Drugs Ther. 2020 04; 34(2):145-152. Tang Y, Liu W, Wang W, Fidler T, Woods B, Levine RL, Tall AR, Wang N. PMID: 32086626; PMCID: PMC7125070.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    10. Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Sci Signal. 2019 04 30; 12(579). Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM. PMID: 31040260; PMCID: PMC6768401.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    11. Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes. 2019 05; 68(5):932-938. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED. PMID: 30765335; PMCID: PMC6477909.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    12. Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice. Circ Res. 2018 11 09; 123(11):e35-e47. Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N. PMID: 30571460; PMCID: PMC6309796.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    13. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 11 07; 21(6):1705. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED. PMID: 29117572; PMCID: PMC5700809.
      View in: PubMed   Mentions: 7     Fields:    
    14. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 08 29; 20(9):2277. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED. PMID: 28854375.
      View in: PubMed   Mentions: 2     Fields:    
    15. Superoxide Dismutase 2 is dispensable for platelet function. Thromb Haemost. 2017 10 05; 117(10):1859-1867. Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED. PMID: 28771279; PMCID: PMC5894334.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    16. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017 07 25; 20(4):881-894. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED. PMID: 28746873; PMCID: PMC5600478.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 Jun 29; 19(7):873. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28659636.
      View in: PubMed   Mentions: 2     Fields:    
    18. Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1628-1639. Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. PMID: 28663252; PMCID: PMC5570649.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May 31; 19(6):740. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28561048.
      View in: PubMed   Mentions:    Fields:    
    20. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 05; 19(5):504-517. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. PMID: 28436964; PMCID: PMC5415409.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    21. Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb; 41(2):379-89. Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS. PMID: 23143891; PMCID: PMC3558858.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    22. Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis. Drug Metab Dispos. 2012 Nov; 40(11):2119-25. Madanayake TW, Fidler TP, Fresquez TM, Bajaj N, Rowland AM. PMID: 22863683; PMCID: PMC3477203.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. Correction to "improved coiled-coil design enhances interaction with bcr-abl and induces apoptosis". Mol Pharm. 2012 May 07; 9(5):1535. Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS. PMID: 22444272; PMCID: PMC3348366.
      View in: PubMed   Mentions: 1     Fields:    
    24. Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis. Mol Pharm. 2012 01 01; 9(1):187-95. Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS. PMID: 22136227; PMCID: PMC3313827.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
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