Immune Activation and Region-specific Myocardial Arrhythmic Substrate in Sudden Cardiac Death Victims with HIV
NIH NHLBI 1R01HL178399Jul 1, 2025 - Jun 30, 2030
Role: Co-PI (contact)
Description: We discovered that people with HIV (PWH) have higher rates of autopsy-confirmed sudden cardiac death (SCD) and higher levels of interstitial myocardial fibrosis (microscopic scarring of the heart) which may underlie lethal heart rhythms. Leveraging our unique biobank of autopsy tissue from victims of SCD, we will test the hypothesis that immune cell activation in the hearts of PWH, with particular specificity for specific layers of the heart, increases the risk of
lethal arrhythmias and SCD via increased tissue fibrosis and disruption of cardiac electrical conduction. |
In Vivo Imaging and Post-Mortem Study of Methamphetamine Use on Immune Dysfunction and HIV Reservoir Transcription among People with HIV on ART
NIH NIDA 1RM1DA063218Jul 1, 2025 - Jun 30, 2030
Role: Multiple PI
Description: The goal of this collaborative, multidisciplinary proposal is to study the impact of methamphetamine use on
whole-body HIV persistence, immune dysfunction, inflammation, and subsequent clinical morbidity. We are
leveraging cohorts of people with HIV on antiviral therapy and the unique San Francisco POstmortem
Systematic InvesTigation of Sudden Cardiac Death (POST SCD) study to perform in-depth, multifaceted
investigations that have the capacity to change clinical paradigm. |
In situ spatial characterization of CNS HIV-host cellular interactions from victims of sudden death
NIH R61DA061826Sep 30, 2024 - Jul 31, 2027
Role: Co-PI |
Whole Body Deep Tissue Characterization of the Human Virome
NIH U01AT012993Sep 13, 2024 - Aug 31, 2029
Role: Co-PI |
COVID-19 POST SCD Study
PolyBio Research Foundation CA-0235823Jan 1, 2024 - Jan 1, 2027
Role: Co-PI
Description: We will leverage the one-of-kind POST SCD biobank for the study of tissue SARS-CoV-2 persistence to uncover potential mechanisms for long-term tissue-based immune responses, inflammation, and damage which may lead to ongoing symptoms. |
The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound
NIH/NIAID 1P01AI169606-01May 1, 2022 - Apr 30, 2027
Role: Co-Investigator |
Clonal Hematopoesis of Indeterminate Potential and Risk of Autopsy-Defined Sudden Cardiac Death
NIH/NHLBI R01HL157247Dec 1, 2021 - Nov 30, 2026
Role: Principal Investigator |
Somatic Mosaicism in Autopsy-Defined Sudden Cardiac Death
Marcus Program Seeding Bold Ideas Award (MP-SBI) May 1, 2021 - Apr 30, 2022
Role: Multiple PI |
Molecular Phenotyping for Autopsy-Defined Sudden Cardiac Death
NIH R01HL147035Jan 1, 2020 - Dec 31, 2023
Role: Principal Investigator |
San Francisco Sudden Death in the Young Registry
CDC CDC DP14-1403Jul 1, 2015 - Jun 30, 2028
Role: Principal Investigator |
Cardiac Pathology and Risk Prediction for Sudden Cardiac Death in Patients with HIV
NIH R01HL126555Sep 15, 2014 - Jun 30, 2020
Role: Principal Investigator |
Comprehensive autopsy characterization of sudden cardiac death
NIH R01HL102090Aug 1, 2010 - May 31, 2016
Role: Principal Investigator |