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Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies. Cell. 2022; 8(185):1431-1443.
Zhu, I., Liu, R., Garcia, J.M., Hyrenius-Wittsten, A., Piraner, D., Alavi, J., Israni, D.V., Liu, B., Khalil, A.S., Roybal, K.T.
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Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 2022; (40):16_s3001.
Aggarwal, R.R., Vuky, J., VanderWeele, D.J., Rettig, M., Heath, E.I., Beer, T.M., Huang, J., Pawlowska, N., Sinit, R., Abbey, J., Liu, B., Nasoff, M., Dorr, A., Small, E.J.
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Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits. Science Translational Medicine. 2021; 591(13):eabd8836.
Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J.M., Perry, N., Montgomery, G., Liu, B*., Roybal, K.T*.
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Molecular imaging of prostate cancer targeting CD46 using immunoPET. Clinical Cancer Res. 2020; 5(27):1305-1315.
Wang, S., Li, J., Hua, J., Su, Y., Beckford-Vera, D., Zhao, W., Jayaraman, M., Huynh, T.L., Zhao, N., Wang, Y.H., Huang, Y., Qin, F., Shen, S., Gioeli, D., Dreicer, R., Sriram, R., Egusa, E.A., Chou, J., Feng, F., Aggarwal, R., Evans, M.J., Seo, Y., Liu, B.*, Flavell, R.R.*, He, J.* .
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Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma. Clinical Cancer Res. 2020; 22(26):6028-6038.
Sherbenou, D.W., Su, Y., Behrens, C.R., Aftab, B.T., Perez de Acha, O., Murnane, M., Bearrows, S.C., Hann, B.C., Wolf, J.L., Martin, T.G., and Liu, B.
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ALPPL2 is a highly specific and targetable tumor cell surface antigen. Cancer Res. 2020; 20(80):4552-4564.
Su, Y., Zhang, X., Bidlingmaier, S., Behrens, C.R., Lee, N.K., and Liu, B.
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Quantitative (99m)Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma. Bioconjug Chem. 2020; 7(31):1750-1755.
He, J., Feng, J., Su, Y., Seo, Y., and Liu, B.
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Manipulation of cell-type selective antibody internalization by a guide-effector bispecific design. Mol Cancer Ther. 2019; 6(18):1092-1103.
Lee, N.K., Su, Y., Bidlingmaier, S., and Liu, B.
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Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018; 17(3):e121497.
Su, Y., Liu, Y., Behrens, C.R., Bidlingmaier, S., Lee, N.K., Aggarwal, R., Sherbenou, D.W., Burlingame, A.L., Hann, B.C., Simko, J.P., Premasekharan, G., Paris, P.L., Shuman, M.A., Seo, Y., Small, E.J., and Liu, B.
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Cell-type specific potent Wnt signaling blockade by bispecific antibody. Sci Rep. 2018; 1(8):766.
Lee, N.K., Zhang, Y., Su, Y., Bidlingmaier, S., Sherbenou, D.W., Ha, K.D., Liu, B.
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Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes. Methods Mol Biol. 2018; (1701):61-82.
Lee, N.K., Bidlingmaier, S., Su, Y., Liu, B.
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Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens. Methods Mol Biol. 2018; (1701):331-347.
Su, Y., Bidlingmaier, S., Lee, N.K., Liu, B.
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Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis. Methods Enzymol. 2017; (585):91-110.
Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.
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Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016; 12(126):4640-4653.
Sherbenou, D.W., Aftab, B.T., Su, Y., Behrens, C.R., Wiita, A., Logan, A.C., Acosta-Alvear, D., Hann, B.C., Walter, P., Shuman, M.A., Wu, X., Atkinson, J.P., Wolf, J.L., Martin, T.G., Liu, B.
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Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing. Mol Cell Proteomics. 2016; 4(15):1232-45.
Bidlingmaier, S., Ha, K., Lee, N.K., Su, Y., Liu, B.
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Macropinocytosis exploitation by cancers and cancer therapy. Frontier Physiology. 2016; (7):381.
Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.
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Identification of novel protein-ligand interactions by exon microarray analysis of yeast surface displayed cDNA library selection outputs. Methods Mol Biol. 2015; (1319):179-92.
Bidlingmaier, S., Liu, B.
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Combining phage and yeast cell surface antibody display to identify novel cell type-selective internalizing human monoclonal antibodies. Methods Mol Biol. 2015; (1319):51-63.
Bidlingmaier, S., Liu, B.
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Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions. Methods Mol Biol. 2015; (1319):203-14.
Bidlingmaier, S. and Liu, B.
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Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries. Methods Mol Biol. 2015; (1319):193-202.
Bidlingmaier, S., Su, Y., and Liu, B.
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The Development of Potential Antibody-Based Therapies for Multiple Myeloma. Blood Rev. 2015; 2(29):81-91.
Sherbenou, D.W., Behrens, C.R. Yang Su, Wolf, J.L., Martin III, T.G., and Liu, B.
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Methods for site-specific drug conjugation to antibodies. MAbs. 2014 Jan-Feb; 6(1):46-53.
Behrens CR, Liu B. PMID: 24135651; PMCID: PMC3929454.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimals
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Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906.
Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. PMID: 23024593; PMCID: PMC3447386.
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19
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An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. Mol Imaging Biol. 2012 Jun; 14(3):336-47.
McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM. PMID: 21630083; PMCID: PMC3227780.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 01; 71(7):2428-32.
Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. PMID: 21447742; PMCID: PMC3071798.
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PubMed Mentions:
9 Fields:
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HumansAnimals
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The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 2011 Apr; 32(10):2605-13.
Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. PMID: 21255833; PMCID: PMC3040448.
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PubMed Mentions:
20 Fields:
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HumansAnimals
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Construction of yeast surface-displayed cDNA libraries. Methods Mol Biol. 2011; 729:199-210.
Bidlingmaier S, Liu B. PMID: 21365492; PMCID: PMC3228857.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries. Methods Mol Biol. 2011; 729:211-23.
Bidlingmaier S, Liu B. PMID: 21365493; PMCID: PMC3229213.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions. Mol Cell Proteomics. 2011 Mar; 10(3):M110.005116.
Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B. PMID: 21127146; PMCID: PMC3047160.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther. 2010 Sep; 18(9):1650-6.
Chen Y, Zhu X, Zhang X, Liu B, Huang L. PMID: 20606648; PMCID: PMC2956922.
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PubMed Mentions:
206 Fields:
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HumansAnimalsCells
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Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment. J Nucl Med. 2010; 3(51):417-32.
He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B.
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Identification of internalizing human single antibodies targeting brain tumor stem cells. Mol Cancer Ther. 2010; 7(9):2131-41.
Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S., and Liu, B.
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Development of a highly stable and targetable nanoliposomal formulation of topotecan. J Control Release. 2010 Jan 04; 141(1):13-21.
Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB. PMID: 19686789.
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PubMed Mentions:
26 Fields:
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HumansAnimalsCells
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Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009 Feb 15; 69(4):1570-7.
Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. PMID: 19221091; PMCID: PMC2752656.
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PubMed Mentions:
34 Fields:
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HumansAnimalsCells
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Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. J Mol Med. 2009; 5(87):507-14.
Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B.
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The utility and limitation of CD133 epitopes in defining tumor stem cell population. J Mol Med. 2008; 9(86):1025-32.
Bidlingmaier, S., Zhu, X., and Liu, B.
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Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies. Mol Cancer Ther. 2008; 3(7):569-78.
An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B.
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Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol Immunol. 2007 Jul; 44(15):3777-88.
Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA. PMID: 17498801; PMCID: PMC2739904.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Explore Cell Type-Specific Internalizing Antibodies For Targeted siRNA Delivery. Brief Funct Genomic Proteomic. 2007; 2(6):112-9.
Liu, B.
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Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther. 2007; 10(6):2737-46.
Roth, A, Conrad, F., Hayes, M., Drummond, D.C., Kirpotin, D.B., Benz, C.C., Marks, J.D., and Liu, B.
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Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins. Mol Cell Proteomics. 2007; 11(6):2012-20.
Bidlingmaier, S and Liu, B.
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Prostate cancer targeting recombinant human IgG1s. J Mol Med. 2007; 10(85):1113-23.
Liu, B., Conrad, F., Roth, A., Drummond, D.C and Marks, J.D.
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Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection. Mol Cell Proteomics. 2006; 12(5):2364-73.
Ruan, W., Sassoon, A., An, F., Simko, J.P., Liu, B.
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Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions. Mol Cell Proteomics. 2006; 3(5):533-40.
Bidlingmaier, S. and Liu, B.
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Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells. Cancer Res. 2004; 2(64):704-710.
Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D.
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Towards proteome-wide production of monoclonal antibody by phage display. J Mol Biol. 2002; 5(315):1063-1073.
Liu, B., Huang, L., Burlingame, A.L., Marks, J.D.
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Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose. Anal Biochem. 2000 Nov 01; 286(1):119-28.
Liu B, Marks JD. PMID: 11038282.
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12 Fields:
Translation:
AnimalsCells
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Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Science. 1995 Feb 24; 267(5201):1131-7.
Liu B, Alberts BM. PMID: 7855590.
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PubMed Mentions:
96 Fields:
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Cells
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Organizational change as human process, not technique. NIDA Res Monogr. 1995; 155:119-31.
Diamond MA. PMID: 8594452.
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1 Fields:
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Humans
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A transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10660-4.
Liu B, Wong ML, Alberts B. PMID: 7524099; PMCID: PMC45081.
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16 Fields:
Translation:
Cells
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The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Nature. 1993 Nov 04; 366(6450):33-9.
Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM. PMID: 8232535.
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37 Fields:
Translation:
Cells