V Courtney Broaddus, MD

InstitutionUniversity of California San Francisco
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986 Medicine
    University of PennsylvaniaResidency 1982School of Medicine
    University of PennsylvaniaMedical Degree1979Medicine
    Duke UniversityBS1975Zoology
    Collapse Awards and Honors
    American Thoracic Society2018Elizabeth Rich Award
    International Mesothelioma Interest Group2016Wagner Medal
    UCSF2012John F. Murray Distinguished Professorship
    The Mesothelioma Applied Research Foundation2010Pioneer Award

    Collapse Research 
    Collapse Research Activities and Funding
    Amplification of TRIAL-Indcued Apoptosis in Mesothelioma
    NIH R01CA095671Mar 12, 2003 - Feb 28, 2009
    Role: Principal Investigator
    NIH R01ES008985Aug 29, 1997 - Jul 31, 2003
    Role: Principal Investigator
    NIH R01ES006331Jul 15, 1994 - Jun 30, 1999
    Role: Principal Investigator
    NIH K08HL001893Aug 1, 1987 - Jul 31, 1992
    Role: Principal Investigator
    NIH F32HL007271Mar 15, 1986
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Follo C, Cheng Y, Richards WG, Bueno R, Broaddus V. Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma. Mol Carcinog. 2018 Mar; 57(3):319-332. PMID: 29073722.
      View in: PubMed
    2. Follo C, Barbone D, Richards WG, Bueno R, Broaddus V. Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome. Autophagy. 2016 Jul 02; 12(7):1180-94. PMID: 27097020; PMCID: PMC4990992.
    3. Barbone D, Van Dam L, Follo C, Jithesh PV, Zhang SD, Richards WG, Bueno R, Fennell DA, Broaddus V. Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. PLoS One. 2016; 11(3):e0150044. PMID: 26982031; PMCID: PMC4794185.
    4. Weinstock T, Kidambi P, Channick CL, Michaud GC, Broaddus V, Makani SS, Wiener RS, Wilson KC, Thomson CC. Implementation of Lung Cancer Screening Programs with Low-Dose Computed Tomography in Clinical Practice. Ann Am Thorac Soc. 2016 Mar; 13(3):425-7. PMID: 26963353.
      View in: PubMed
    5. Barbone D, Follo C, Echeverry N, Gerbaudo VH, Klabatsa A, Bueno R, Felley-Bosco E, Broaddus V. Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models. PLoS One. 2015; 10(8):e0134825. PMID: 26284517; PMCID: PMC4540424.
    6. Broaddus V, Grippi MA. Medical Subspecialty Textbooks in the 21st Century. Essential or Headed for Extinction? Ann Am Thorac Soc. 2015 Aug; 12(8):1113-5. PMID: 26177458.
      View in: PubMed
    7. Busacca S, Chacko AD, Klabatsa A, Arthur K, Sheaff M, Barbone D, Mutti L, Gunasekharan VK, Gorski JJ, El-Tanani M, Broaddus V, Gaudino G, Fennell DA. BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma. PLoS One. 2013; 8(6):e65489. PMID: 23762382; PMCID: PMC3676324.
    8. Barbone D, Cheung P, Battula S, Busacca S, Gray SG, Longley DB, Bueno R, Sugarbaker DJ, Fennell DA, Broaddus V. Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression. PLoS One. 2012; 7(12):e52753. PMID: 23300762; PMCID: PMC3530471.
    9. Lee HK, Park GB, Kim YS, Song H, Broaddus V, Hur DY. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. Int J Oncol. 2013 Feb; 42(2):469-77. PMID: 23232551; PMCID: PMC3583643.
    10. Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus V, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB. Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent. Eur J Cancer. 2012 May; 48(7):1096-107. PMID: 22154545.
      View in: PubMed
    11. Phung YT, Barbone D, Broaddus V, Ho M. Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy. J Cancer. 2011; 2:507-14. PMID: 22043235; PMCID: PMC3204399.
    12. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus V, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 01; 71(7):2428-32. PMID: 21447742; PMCID: PMC3071798.
    13. Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus V, Hassan R, Fitzgerald D, Ho M. The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. PLoS One. 2011 Jan 31; 6(1):e14640. PMID: 21305058; PMCID: PMC3031536.
    14. Broaddus V, Everitt JI, Black B, Kane AB. Non-neoplastic and neoplastic pleural endpoints following fiber exposure. J Toxicol Environ Health B Crit Rev. 2011; 14(1-4):153-78. PMID: 21534088; PMCID: PMC3118521.
    15. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus V, Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009 Feb 15; 69(4):1570-7. PMID: 19221091; PMCID: PMC2752656.
    16. Yang TM, Barbone D, Fennell DA, Broaddus V. Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. Am J Respir Cell Mol Biol. 2009 Jul; 41(1):14-23. PMID: 19097992; PMCID: PMC2701959.
    17. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus V. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83. PMID: 18511708; PMCID: PMC2574528.
    18. Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus V. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J Biol Chem. 2008 May 09; 283(19):13021-30. PMID: 18339627; PMCID: PMC2442321.
    19. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus V, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78. PMID: 18319332; PMCID: PMC2943512.
    20. Hassan R, Broaddus V, Wilson S, Liewehr DJ, Zhang J. Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts. Clin Cancer Res. 2007 Dec 01; 13(23):7166-71. PMID: 18056197.
      View in: PubMed
    21. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus V, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.
    22. Abayasiriwardana KS, Barbone D, Kim KU, Vivo C, Lee KK, Dansen TB, Hunt AE, Evan GI, Broaddus V. Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim. Mol Cancer Ther. 2007 Oct; 6(10):2766-76. PMID: 17938269.
      View in: PubMed
    23. Pespeni MH, Hodnett M, Abayasiriwardana KS, Roux J, Howard M, Broaddus V, Pittet JF. Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway. Cancer Res. 2007 Mar 15; 67(6):2865-71. PMID: 17363610.
      View in: PubMed
    24. Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, Broaddus V. A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance. Am J Respir Cell Mol Biol. 2005 Dec; 33(6):541-8. PMID: 16123394; PMCID: PMC2715331.
    25. Broaddus V, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI. Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage. J Biol Chem. 2005 Apr 01; 280(13):12486-93. PMID: 15615731.
      View in: PubMed
    26. Mutti L, Broaddus V. Malignant mesothelioma as both a challenge and an opportunity. Oncogene. 2004 Dec 09; 23(57):9155-61. PMID: 15516978.
      View in: PubMed
    27. Leard LE, Broaddus V. Mesothelial cell proliferation and apoptosis. Respirology. 2004 Aug; 9(3):292-9. PMID: 15362999.
      View in: PubMed
    28. Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus V. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L448-53. PMID: 15121637.
      View in: PubMed
    29. Fjellbirkeland L, Cambier S, Broaddus V, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL. Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol. 2003 Aug; 163(2):533-42. PMID: 12875973; PMCID: PMC1868219.
    30. Vivo C, Liu W, Broaddus V. c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. J Biol Chem. 2003 Jul 11; 278(28):25461-7. PMID: 12707267.
      View in: PubMed
    31. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus V, Nishimura SL. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507. PMID: 11970960.
      View in: PubMed