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V Courtney Broaddus, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
AddressLocation Required
Varies CA 00000
Phone415-206-3513
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986 Medicine
    University of PennsylvaniaResidency 1982School of Medicine
    University of PennsylvaniaMedical Degree1979Medicine
    Duke UniversityBS1975Zoology
    Collapse Awards and Honors
    American Thoracic Society2018Elizabeth Rich Award
    International Mesothelioma Interest Group2016Wagner Medal
    UCSF2012John F. Murray Distinguished Professorship
    The Mesothelioma Applied Research Foundation2010Pioneer Award

    Collapse Research 
    Collapse Research Activities and Funding
    Amplification of TRIAL-Indcued Apoptosis in Mesothelioma
    NIH R01CA095671Mar 12, 2003 - Feb 28, 2009
    Role: Principal Investigator
    PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    NIH R01ES008985Aug 29, 1997 - Jul 31, 2003
    Role: Principal Investigator
    MOLECULAR INTERACTIONS ON ASBESTOS AND MESOTHELIAL CELLS
    NIH R01ES006331Jul 15, 1994 - Jun 30, 1999
    Role: Principal Investigator
    COMPARATIVE PHYSIOLOGY OF THE NORMAL AND INFLAMED PLEURA
    NIH K08HL001893Aug 1, 1987 - Jul 31, 1992
    Role: Principal Investigator
    PLEURAL LIQUID TRANSPORT
    NIH F32HL007271Mar 15, 1986
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Follo C, Cheng Y, Richards WG, Bueno R, Broaddus VC. Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma. Mol Carcinog. 2018 Mar; 57(3):319-332. PMID: 29073722.
      View in: PubMed
    2. Follo C, Barbone D, Richards WG, Bueno R, Broaddus VC. Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome. Autophagy. 2016 Jul 02; 12(7):1180-94. PMID: 27097020; PMCID: PMC4990992.
    3. Barbone D, Van Dam L, Follo C, Jithesh PV, Zhang SD, Richards WG, Bueno R, Fennell DA, Broaddus VC. Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. PLoS One. 2016; 11(3):e0150044. PMID: 26982031; PMCID: PMC4794185.
    4. Weinstock T, Kidambi P, Channick CL, Michaud GC, Broaddus C, Makani SS, Wiener RS, Wilson KC, Thomson CC. Implementation of Lung Cancer Screening Programs with Low-Dose Computed Tomography in Clinical Practice. Ann Am Thorac Soc. 2016 Mar; 13(3):425-7. PMID: 26963353.
      View in: PubMed
    5. Barbone D, Follo C, Echeverry N, Gerbaudo VH, Klabatsa A, Bueno R, Felley-Bosco E, Broaddus VC. Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models. PLoS One. 2015; 10(8):e0134825. PMID: 26284517; PMCID: PMC4540424.
    6. Broaddus VC, Grippi MA. Medical Subspecialty Textbooks in the 21st Century. Essential or Headed for Extinction? Ann Am Thorac Soc. 2015 Aug; 12(8):1113-5. PMID: 26177458.
      View in: PubMed
    7. Busacca S, Chacko AD, Klabatsa A, Arthur K, Sheaff M, Barbone D, Mutti L, Gunasekharan VK, Gorski JJ, El-Tanani M, Broaddus VC, Gaudino G, Fennell DA. BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma. PLoS One. 2013; 8(6):e65489. PMID: 23762382; PMCID: PMC3676324.
    8. Barbone D, Cheung P, Battula S, Busacca S, Gray SG, Longley DB, Bueno R, Sugarbaker DJ, Fennell DA, Broaddus VC. Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression. PLoS One. 2012; 7(12):e52753. PMID: 23300762; PMCID: PMC3530471.
    9. Lee HK, Park GB, Kim YS, Song H, Broaddus VC, Hur DY. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. Int J Oncol. 2013 Feb; 42(2):469-77. PMID: 23232551; PMCID: PMC3583643.
    10. Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus VC, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB. Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent. Eur J Cancer. 2012 May; 48(7):1096-107. PMID: 22154545.
      View in: PubMed
    11. Phung YT, Barbone D, Broaddus VC, Ho M. Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy. J Cancer. 2011; 2:507-14. PMID: 22043235; PMCID: PMC3204399.
    12. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 01; 71(7):2428-32. PMID: 21447742; PMCID: PMC3071798.
    13. Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D, Ho M. The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. PLoS One. 2011 Jan 31; 6(1):e14640. PMID: 21305058; PMCID: PMC3031536.
    14. Broaddus VC, Everitt JI, Black B, Kane AB. Non-neoplastic and neoplastic pleural endpoints following fiber exposure. J Toxicol Environ Health B Crit Rev. 2011; 14(1-4):153-78. PMID: 21534088; PMCID: PMC3118521.
    15. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009 Feb 15; 69(4):1570-7. PMID: 19221091; PMCID: PMC2752656.
    16. Yang TM, Barbone D, Fennell DA, Broaddus VC. Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. Am J Respir Cell Mol Biol. 2009 Jul; 41(1):14-23. PMID: 19097992; PMCID: PMC2701959.
    17. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83. PMID: 18511708; PMCID: PMC2574528.
    18. Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus VC. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J Biol Chem. 2008 May 09; 283(19):13021-30. PMID: 18339627; PMCID: PMC2442321.
    19. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78. PMID: 18319332; PMCID: PMC2943512.
    20. Hassan R, Broaddus VC, Wilson S, Liewehr DJ, Zhang J. Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts. Clin Cancer Res. 2007 Dec 01; 13(23):7166-71. PMID: 18056197.
      View in: PubMed
    21. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.