Yu Zhou, PhD

Title(s)Associate Professor, Anesthesia
SchoolSchool of Medicine
Address2540 23rd Street, #5709
San Francisco CA 94110
ORCID ORCID Icon0000-0002-5130-4042 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Internalizing and cross-reactive human mAbs to tumor associate antigen
    ImmunoGen, Inc. A131104Apr 1, 2018 - Mar 31, 2019
    Role: Principal Investigator
    Cross reactive human mAbs to tumor associated antigens
    Merrimack Pharmaceuticals, Inc. A128580Aug 1, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Description: Lead the development and application of display antibody libraries for isolation of human monoclonal antibodies to various immune-oncology targets, direct the research, construct and supervise the overall research plan
    The antibody technology research center: renewable antibodies to biomedical relevant antigens
    NIH/NCI 1P41CA196276-01Nov 1, 2014 - Oct 31, 2019
    Role: Co-Investigator
    Description: Lead the Project 1 to construct nature-inspired recombinant antibody libraries, develop high-throughput antibody selection platform, identify target specific antibodies, and study antibody structure-function relationship.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity. Sci Transl Med. 2019 10 02; 11(512). Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, Dugast AS, Zhang H, Depis F, Feau S, Jakubowski A, Qiao W, Craig G, Razlog M, Qiu J, Zhou Y, Marks JD, Croft M, Drummond DC, Raue A. PMID: 31578241.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    2. Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models. Nat Biomed Eng. 2019 04; 3(4):264-280. Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, Wilton JH, Geddie ML, Suchy J, Grabow S, Kohli N, Reynolds CP, Blaydes R, Zhou Y, Sawyer AJ, Marks JD, Drummond DC. PMID: 30952988.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    3. Discovery of internalizing antibodies to basal breast cancer cells. Protein Eng Des Sel. 2018 01 01; 31(1):17-28. Zhou Y, Zou H, Yau C, Zhao L, Hall SC, Drummond DC, Farr-Jones S, Park JW, Benz CC, Marks JD. PMID: 29301020; PMCID: PMC6283401.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5. Mol Cancer Ther. 2015 Nov; 14(11):2595-605. Le Gall M, Crépin R, Neiveyans M, Auclair C, Fan Y, Zhou Y, Marks JD, Pèlegrin A, Poul MA. PMID: 26358753; PMCID: PMC6013065.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation. Leukemia. 2016 Mar; 30(3):692-700. Seldon TA, Pryor R, Palkova A, Jones ML, Verma ND, Findova M, Braet K, Sheng Y, Fan Y, Zhou EY, Marks JD, Munro T, Mahler SM, Barnard RT, Fromm PD, Silveira PA, Elgundi Z, Ju X, Clark GJ, Bradstock KF, Munster DJ, Hart DN. PMID: 26286117.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    6. A fully human scFv phage display library for rapid antibody fragment reformatting. Protein Eng Des Sel. 2015 Oct; 28(10):307-16. Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Mallick P, Reiter RE, Wu AM. PMID: 25991864; PMCID: PMC4607741.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    7. High throughput identification of monoclonal antibodies to membrane bound and secreted proteins using yeast and phage display. PLoS One. 2014; 9(10):e111339. Zhao L, Qu L, Zhou J, Sun Z, Zou H, Chen YY, Marks JD, Zhou Y. PMID: 25353955; PMCID: PMC4213037.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments. Mol Cancer Ther. 2014 Nov; 13(11):2607-17. Li K, Tavaré R, Zettlitz KA, Mumenthaler SM, Mallick P, Zhou Y, Marks JD, Wu AM. PMID: 25143449; PMCID: PMC4221648.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    9. Identifying blood-brain-barrier selective single-chain antibody fragments. Biotechnol J. 2014 May; 9(5):664-74. Jones AR, Stutz CC, Zhou Y, Marks JD, Shusta EV. PMID: 24644233; PMCID: PMC4073886.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    10. N-Terminal labeling of filamentous phage to create cancer marker imaging agents. ACS Nano. 2012 Aug 28; 6(8):6675-80. Carrico ZM, Farkas ME, Zhou Y, Hsiao SC, Marks JD, Chokhawala H, Clark DS, Francis MB. PMID: 22830952; PMCID: PMC3435507.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    11. Selection and characterization of cell binding and internalizing phage antibodies. Arch Biochem Biophys. 2012 Oct 15; 526(2):107-13. Zhou Y, Zhao L, Marks JD. PMID: 22627065; PMCID: PMC4209712.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies. Mol Cancer Ther. 2012 Jul; 11(7):1467-76. Zhou Y, Goenaga AL, Harms BD, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD. PMID: 22564724; PMCID: PMC4209485.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    13. Building and characterizing antibody-targeted lipidic nanotherapeutics. Methods Enzymol. 2012; 502:139-66. Kirpotin DB, Noble CO, Hayes ME, Huang Z, Kornaga T, Zhou Y, Nielsen UB, Marks JD, Drummond DC. PMID: 22208985.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    14. Discovery of internalizing antibodies to tumor antigens from phage libraries. Methods Enzymol. 2012; 502:43-66. Zhou Y, Marks JD. PMID: 22208981; PMCID: PMC4180867.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast-displayed tumor antigens. J Mol Biol. 2010 Nov 19; 404(1):88-99. Zhou Y, Zou H, Zhang S, Marks JD. PMID: 20851130; PMCID: PMC4195448.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. TSG101 exposure on the surface of HIV-1 infected cells: implications for monoclonal antibody therapy for HIV/AIDS. Am J Transl Res. 2010 Jul 20; 2(4):368-80. Diaz L, Mao H, Zhou Y, Kohli M, Cassella J, Santos D, Fesseha Z, Weng K, Chen H, Bamba D, Marks JD, Goldblatt M, Kinch M. PMID: 20733947; PMCID: PMC2923861.
      View in: PubMed   Mentions: 2  
    17. An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors. Eur J Nucl Med Mol Imaging. 2010 Aug; 37(8):1529-38. Lepin EJ, Leyton JV, Zhou Y, Olafsen T, Salazar FB, McCabe KE, Hahm S, Marks JD, Reiter RE, Wu AM. PMID: 20354850; PMCID: PMC2903645.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    18. Identification of target and function specific antibodies for effective drug delivery. Methods Mol Biol. 2009; 525:145-60, xv. Zhou Y, Marks JD. PMID: 19252832.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Development of human single-chain antibodies against SARS-associated coronavirus. Intervirology. 2008; 51(3):173-81. Leung KM, Feng DX, Lou J, Zhou Y, Fung KP, Waye MM, Tsui SK, Chan PK, Marks JD, Pang SF, Kan YW. PMID: 18724064; PMCID: PMC7179547.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol Immunol. 2007 Jul; 44(15):3777-88. Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA. PMID: 17498801; PMCID: PMC2739904.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells. J Mol Biol. 2007 Aug 24; 371(4):934-47. Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD. PMID: 17602702; PMCID: PMC4198021.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    22. Isolation of scFvs to in vitro produced extracellular domains of EGFR family members. Cancer Biother Radiopharm. 2005 Dec; 20(6):603-13. Horak E, Heitner T, Robinson MK, Simmons HH, Garrison J, Russeva M, Furmanova P, Lou J, Zhou Y, Yuan QA, Weiner LM, Adams GP, Marks JD. PMID: 16398612.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
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