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    Dorit Ron, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94143
    Phone415-502-7620

       Overview 
       Overview
      Dr. Ron is a graduate of the School of Pharmacy at the Hebrew University Jerusalem, Israel. She obtained her PhD in Pharmacology from the Hebrew University Jerusalem. She then did her postdoctoral training at The University of California, San Francisco (UCSF) and Stanford University studying the role of scaffolding proteins in signal transduction under the mentorship of Prof. Daria Mochly-Rosen. She has been at the Ernest Gallo Research Center at UCSF for over 10 years. Dr. Ron is a Professor in the Department of Neurology at UCSF and a member of the Neuroscience Graduate Program. She is also the Endowed Chair in Cell Biology of Addiction in Neurology at UCSF, the Scientific Director for a P50 NIH-NIAAA Center Grant and the Director of Intramural Programs at the Ernest Gallo Research Center. She is a recipient of three NIH RO1 grant awards, and is an Associate Editor for the Journal of Neuroscience, Addiction Biology, the Alcohol Journal, as well as a field editor for Alcoholism: Clinical and Experimental Research.

      Dr. Ron's research focuses on the molecular neurobiology of alcohol use disorders for which her laboratory uses molecular, electrophysiological and rodent behavior approaches. Dr. Ron's areas of expertise are: molecular neuroscience, signal transduction, neurobiology of addiction and psychiatric disorders. She has published extensively in high impact factor journals such as Proceedings of the National Academy of Sciences USA, the Journal of Neuroscience, FASEB Journal, Biological Psychiatry, the Journal of Biological Chemistry and many others. Over the years her group has made several major contributions to the field of addiction and identified novel targets that could potentially be developed as therapeutics to treat alcohol addiction. Several of her studies resulted in UCSF press releases which received the attention of both the scientific community and the general public.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Neasta J, Barak S, Hamida SB, Ron D. mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem. 2014 Jul; 130(2):172-84.
        View in: PubMed
      2. Becker HC, Ron D. Animal models of excessive alcohol consumption: Recent advances and future challenges. Alcohol. 2014 May; 48(3):205-8.
        View in: PubMed
      3. Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. J Neurochem. 2014 Jun; 129(6):1024-34.
        View in: PubMed
      4. Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014 May; 48(3):243-52.
        View in: PubMed
      5. Warnault V, Ron D. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov; 5(17):2011-3.
        View in: PubMed
      6. Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D. Protein tyrosine phosphatase a in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. J Neurosci. 2013 Sep 4; 33(36):14369-78.
        View in: PubMed
      7. Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. RACK1 to the future--a historical perspective. Cell Commun Signal. 2013; 11:53.
        View in: PubMed
      8. Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug; 16(8):1094-100.
        View in: PubMed
      9. Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH and Ron D. Nature Neurosci June 3, 2013 [epub ahead of print]. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. 2013.
      10. Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug; 16(8):1111-7.
        View in: PubMed
      11. Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct; 37(10):1680-7.
        View in: PubMed
      12. Ahmadiantehrani S, Barak S, Ron D. GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul; 19(4):623-33.
        View in: PubMed
      13. Warnault V, Darcq E, Levine A, Barak S, Ron D. Transl Psychiatry. Chromatin remodeling - A novel strategy to control excessive alcohol drinking. 2013; e231(3).
      14. Ahmadiantehrani S, Barak S and Ron D. Addiction Biology January 9, 2013 [epub ahead of print]. GDNF is a novel ethanol-responsive gene in the VTA: Implications for the development and persistence of excessive drinking. 2013.
      15. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Alcohol: Clin Exp Res. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. 2013; 37:8-15.
      16. Ahmadiantehrani S and Ron D. J Neurochem. Dopamine D2 receptor activation leads to an upregulation of glial cell line-derived neurotrophic factor via Gbetagamma-Erk1/2-dependent induction of Zif268. 2013; 125:193-204.
      17. Jeanblanc J, Logrip ML, Janak PH, Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb; 37(4):607-12.
        View in: PubMed
      18. Martino MB, Jones L, Brighton B, Ehre C, Abdulah L, Davis CW, Ron D, O'Neal WK, Ribeiro CM. The ER stress transducer IRE1ß is required for airway epithelial mucin production. Mucosal Immunol. 2013 May; 6(3):639-54.
        View in: PubMed
      19. Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, Ron D. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. J Neurosci. 2012 Oct 24; 32(43):15124-32.
        View in: PubMed
      20. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan; 37(1):8-15.
        View in: PubMed
      21. Rewal M, Donahue R, Gill TM, Nie H, Ron D, Janak PH. . Addic Biol. Alpha4 subunit-containing GABA(A) receptors in the accumbens shell contribute to the reinforcing effects of alcohol. 2012; 17:309-21.
      22. Ron D, Messing RO. Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Signaling pathways mediating alcohol effects. 2012; 13:87-126.
      23. Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D. . J Biol Chem. Direct interaction between scaffolding proteins RACK1 and 14-3-3zeta regulates brain-derived neurotrophic factor (BDNF) transcription. 2012; 287:322-36.
      24. Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D. J Neurosci. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. 2012; 32:15849-15858.
      25. Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S and Ron D. J Neurosci. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: Implications for alcohol drinking behavior. 2012; 32:15124-15132.
      26. Adams DR, Ron D, Kiely PA. RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal. 2011; 9:22.
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      27. Barak S, Carnicella S, Yowell QV, Ron D. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J Neurosci. 2011 Jul 6; 31(27):9885-94.
        View in: PubMed
      28. Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcohol Clin Exp Res. 2011 Oct; 35(10):1739-48.
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      29. Neasta J, Ben Hamida S, Yowell QV, Carnicella S, Ron D. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biol Psychiatry. 2011 Sep 15; 70(6):575-82.
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      30. Wang J, Lanfranco MF, Gibb SL, Ron D. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-Jun; 5(3):205-9.
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      31. Nie H, Rewal M, Gill TM, Ron D, Janak PH. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4459-64.
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      32. Gibb SL, Jeanblanc J, Barak S, Yowell QV, Yaka R, Ron D. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J Neurosci. 2011 Feb 9; 31(6):2180-7.
        View in: PubMed
      33. Gibb SL, Hamida SB, Lanfranco MF, Ron D. . J Neurochem. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase alpha. 2011; 119:879-89.
      34. Gibb SL, Ben Hamida S, Lanfranco MF, Ron D. J Neurochem. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase alpha. 2011; 119:879-89.
      35. Barak S, Ahmadiantehrani S, Kharazia V, Ron D. Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry. 2011; 1.
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      36. Neasta J, Ben Hamida S, Yowell Q, Carnicella S, Ron D. Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20093-8.
        View in: PubMed
      37. Wang J, Carnicella S, Ahmadiantehrani S, He DY, Barak S, Kharazia V, Ben Hamida S, Zapata A, Shippenberg TS, Ron D. Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system. J Neurosci. 2010 Oct 27; 30(43):14502-12.
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      38. Carnicella S, Yowell QV, Ron D. Regulation of operant oral ethanol self-administration: a dose-response curve study in rats. Alcohol Clin Exp Res. 2011 Jan; 35(1):116-25.
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      39. Carnicella S, He DY, Yowell QV, Glick SD, Ron D. Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. Addict Biol. 2010 Oct; 15(4):424-33.
        View in: PubMed
      40. Wang J, Lanfranco MF, Gibb SL, Yowell QV, Carnicella S, Ron D. Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse. J Neurosci. 2010 Jul 28; 30(30):10187-98.
        View in: PubMed
      41. He DY, Neasta J, Ron D. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18; 285(25):19043-50.
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      42. Jeanblanc J, He DY, Carnicella S, Kharazia V, Janak PH, Ron D. Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci. 2009 Oct 28; 29(43):13494-502.
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      43. Logrip ML, Janak PH, Ron D. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug; 43(5):359-65.
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      44. Logrip ML, Janak PH, Ron D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem. 2009 Jun; 109(5):1459-68.
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      45. Carnicella S, Ahmadiantehrani S, Janak PH, Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun; 33(6):1012-24.
        View in: PubMed
      46. Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH, Ron D. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15; 66(2):146-53.
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      47. Carnicella S, Amamoto R, Ron D. Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol. 2009 Feb; 43(1):35-43.
        View in: PubMed
      48. Rewal M, Jurd R, Gill TM, He DY, Ron D, Janak PH. Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci. 2009 Jan 14; 29(2):543-9.
        View in: PubMed
      49. Carnicella S, Ron D. GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr; 122(1):9-18.
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      50. Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 1; 415(1):77-85.
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      51. Carnicella S, Kharazia V, Jeanblanc J, Janak PH, Ron D. GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8114-9.
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      52. He DY, Ron D. Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. J Biol Chem. 2008 May 9; 283(19):12811-8.
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      53. Logrip ML, Janak PH, Ron D. Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. FASEB J. 2008 Jul; 22(7):2393-404.
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      54. Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb SL, Ron D. Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem. 2008 Jan 4; 283(1):301-10.
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      55. Newton PM, Ron D. Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun; 55(6):570-7.
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      56. Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, Janak PH, Lovinger DM, Ron D. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci. 2007 Mar 28; 27(13):3593-602.
        View in: PubMed
      57. He DY, Ron D. Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. FASEB J. 2006 Nov; 20(13):2420-2.
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      58. Schilström B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D, Bonci A. Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci. 2006 Aug 16; 26(33):8549-58.
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      59. Kiely PA, O'Gorman D, Luong K, Ron D, O'Connor R. Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol Cell Biol. 2006 Jun; 26(11):4041-51.
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      60. Szumlinski KK, Abernathy KE, Oleson EB, Klugmann M, Lominac KD, He DY, Ron D, During M, Kalivas PW. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr; 31(4):768-77.
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      61. Woodward JJ, Ron D, Winder D, Roberto M. From blue states to up states: a regional view of NMDA-ethanol interactions. Alcohol Clin Exp Res. 2006 Feb; 30(2):359-67.
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      62. Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D. The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci. 2006 Feb 1; 26(5):1457-64.
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      63. Janak PH, Wolf FW, Heberlein U, Pandey SC, Logrip ML, Ron D. BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res. 2006 Feb; 30(2):214-21.
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      64. Ashique AM, Kharazia V, Yaka R, Phamluong K, Peterson AS, Ron D. Localization of the scaffolding protein RACK1 in the developing and adult mouse brain. Brain Res. 2006 Jan 19; 1069(1):31-8.
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      65. Ron D, Jurd R. The "ups and downs" of signaling cascades in addiction. Sci STKE. 2005 Nov 8; 2005(309):re14.
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      66. Suvarna N, Borgland SL, Wang J, Phamluong K, Auberson YP, Bonci A, Ron D. Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem. 2005 Sep 9; 280(36):31450-9.
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      67. He DY, McGough NN, Ravindranathan A, Jeanblanc J, Logrip ML, Phamluong K, Janak PH, Ron D. Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J Neurosci. 2005 Jan 19; 25(3):619-28.
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      68. Ron D, Janak PH. GDNF and addiction. Rev Neurosci. 2005; 16(4):277-85.
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      69. McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci. 2004 Nov 17; 24(46):10542-52.
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      70. Ron D. Signaling cascades regulating NMDA receptor sensitivity to ethanol. Neuroscientist. 2004 Aug; 10(4):325-36.
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      71. Thornton C, Tang KC, Phamluong K, Luong K, Vagts A, Nikanjam D, Yaka R, Ron D. Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biol Chem. 2004 Jul 23; 279(30):31357-64.
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      72. Yaka R, Tang KC, Camarini R, Janak PH, Ron D. Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcohol Clin Exp Res. 2003 Nov; 27(11):1736-42.
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      73. Vagts AJ, He DY, Yaka R, Ron D. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcohol Clin Exp Res. 2003 Oct; 27(10):1599-605.
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      74. Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron. 2003 Jul 31; 39(3):401-7.
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      75. Yaka R, Phamluong K, Ron D. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci. 2003 May 1; 23(9):3623-32.
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      76. Thornton C, Yaka R, Dinh S, Ron D. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biol Chem. 2003 Jun 27; 278(26):23823-9.
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      77. Yaka R, He DY, Phamluong K, Ron D. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003 Mar 14; 278(11):9630-8.
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      78. Schechtman D, Mochly-Rosen D, Ron D. Glutathione S-transferase pull-down assay. Methods Mol Biol. 2003; 233:345-50.
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      79. Olive MF, Ron D. Alcohol addiction. Methods Mol Biol. 2003; 233:555-70.
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      80. He DY, Vagts AJ, Yaka R, Ron D. Ethanol induces gene expression via nuclear compartmentalization of receptor for activated C kinase 1. Mol Pharmacol. 2002 Aug; 62(2):272-80.
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      81. Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5710-5.
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      82. Ron D, Vagts AJ, Dohrman DP, Yaka R, Jiang Z, Yao L, Crabbe J, Grisel JE, Diamond I. Uncoupling of betaIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB J. 2000 Nov; 14(14):2303-14.
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