-
The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice. J Neurosci. 2024 Jul 17; 44(29).
Hoisington ZW, Salvi A, Laguesse S, Ehinger Y, Shukla C, Phamluong K, Ron D. PMID: 38886056; PMCID: PMC11255432.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory. bioRxiv. 2024 Jun 13.
Hoisington ZW, Gangal H, Phamluong K, Shukla C, Ehinger Y, Moffat JJ, Homanics GE, Wang J, Ron D. PMID: 38915579; PMCID: PMC11195216.
View in:
PubMed Mentions:
-
Sex Differences In The Interaction Between Alcohol And mTORC1. bioRxiv. 2024 Apr 25.
Ehinger Y, Phamluong K, Ron D. PMID: 38712221; PMCID: PMC11071286.
View in:
PubMed Mentions:
-
The small G-protein Rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice. bioRxiv. 2024 Apr 18.
Hoisington ZW, Salvi A, Laguesse S, Ehinger Y, Shukla C, Phamluong K, Ron D. PMID: 37693512; PMCID: PMC10491244.
View in:
PubMed Mentions:
-
Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis. bioRxiv. 2023 Dec 01.
Ehinger Y, Laguesse S, Phamluong K, Salvi A, Hoisington ZW, Soneja D, Sei YJ, Nakamura K, Ron D. PMID: 38076984; PMCID: PMC10705386.
View in:
PubMed Mentions:
-
Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking. Neuropsychopharmacology. 2024 Apr; 49(5):824-836.
da Silva D, Matsui A, Murray EM, Mamais A, Authement ME, Shin JH, Shaw M, Ron D, Cookson MR, Alvarez VA. PMID: 37684522; PMCID: PMC10948780.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Alcohol Inhibits Glycolysis in the Nucleus Accumbens of Mice Through mTORC1-Dependent Repression of Translation. Alcohol. 2023 Jun 1; 109:74.
Ron RD, Ehinger EY, Salvi SA, Phamluong PK, Sei SY, Sonja SD, Whiteley WE, Laguesse LS, Nakamura NK. .
View in:
Publisher Site Mentions:
-
The Small G-Protein Rac1 Promotes Neuroadaptations that Underlie Alcohol Use Disorder. Alcohol. 2023 Jun 1; 109:99-100.
Hoisington HZ, Salvi SA, Phamluong PK, Ehinger EY, Ron RD. .
View in:
Publisher Site Mentions:
-
Identification of Novel BDNF-Specific Corticostriatal Circuitries. eNeuro. 2023 05; 10(5).
Ehinger Y, Soneja D, Phamluong K, Salvi A, Ron D. PMID: 37156610; PMCID: PMC10198608.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice. Psychopharmacology (Berl). 2023 Feb; 240(2):303-317.
Moffat JJ, Sakhai SA, Hoisington ZW, Ehinger Y, Ron D. PMID: 36622381; PMCID: PMC9879818.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Correction: mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking. Elife. 2022 May 04; 11.
Morisot N, Phamluong K, Ehinger Y, Berger AL, Moffat JJ, Ron D. PMID: 35507409; PMCID: PMC9068206.
View in:
PubMed Mentions: Fields:
-
Alcohol and the brain: from genes to circuits. Trends Neurosci. 2021 12; 44(12):1004-1015.
Egervari G, Siciliano CA, Whiteley EL, Ron D. PMID: 34702580; PMCID: PMC8616825.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
-
Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice. Nat Commun. 2021 07 27; 12(1):4407.
Ehinger Y, Zhang Z, Phamluong K, Soneja D, Shokat KM, Ron D. PMID: 34315870; PMCID: PMC8316332.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. 2021 01; 589(7842):474-479.
Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. PMID: 33299186; PMCID: PMC7874389.
View in:
PubMed Mentions:
125 Fields:
Translation:
Animals
-
Growth Factors and Alcohol Use Disorder. Cold Spring Harb Perspect Med. 2020 12 01; 10(12).
Liran M, Rahamim N, Ron D, Barak S. PMID: 31964648; PMCID: PMC7371553.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Investigating the link between serum concentrations of brain-derived neurotrophic factor and behavioral measures in anxious alcohol-dependent individuals. Alcohol. 2020 12; 89:75-83.
Portelli J, Farokhnia M, Deschaine SL, Battista JT, Lee MR, Li X, Ron D, Leggio L. PMID: 32798692; PMCID: PMC7722014.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Astrocytes and alcohol: cortical astrocytes regulate alcohol consumption and intoxication. Neuropsychopharmacology. 2021 02; 46(3):487-488.
Moffat JJ, Ron D. PMID: 32561855; PMCID: PMC8026953.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use. Neuropsychopharmacology. 2021 01; 46(2):334-342.
Ehinger Y, Morisot N, Phamluong K, Sakhai SA, Soneja D, Adrover MF, Alvarez VA, Ron D. PMID: 32417851; PMCID: PMC7852539.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Addict Biol. 2021 03; 26(2):e12890.
Ehinger Y, Phamluong K, Darevesky D, Welman M, Moffat JJ, Sakhai SA, Whiteley EL, Berger AL, Laguesse S, Farokhnia M, Leggio L, Lordkipanidzé M, Ron D. PMID: 32135570; PMCID: PMC7483353.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking. Elife. 2019 12 11; 8.
Morisot N, Phamluong K, Ehinger Y, Berger AL, Moffat JJ, Ron D. PMID: 31820733; PMCID: PMC6959998.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
Protein Translation and Psychiatric Disorders. Neuroscientist. 2020 02; 26(1):21-42.
Laguesse S, Ron D. PMID: 31271100; PMCID: PMC7255087.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking. Addict Biol. 2019 11; 24(6):1227-1234.
Morisot N, Berger AL, Phamluong K, Cross A, Ron D. PMID: 30536923; PMCID: PMC7032525.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors. Neuropsychopharmacology. 2019 03; 44(4):805-816.
Dobbs LK, Kaplan AR, Bock R, Phamluong K, Shin JH, Bocarsly ME, Eberhart L, Ron D, Alvarez VA. PMID: 30504927; PMCID: PMC6372593.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. 2018 09 15; 140:35-42.
Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC. PMID: 30056122; PMCID: PMC6113096.
View in:
PubMed Mentions:
19 Fields:
Translation:
Animals
-
Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking. Addict Biol. 2019 09; 24(5):908-920.
Ben Hamida S, Laguesse S, Morisot N, Park JH, Phuamluong K, Berger AL, Park KD, Ron D. PMID: 30022576; PMCID: PMC7255088.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Special issue on new technologies for alcohol research and treatment. Alcohol. 2019 02; 74:1-2.
Ron D, Weiner J. PMID: 30409742.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies. Dev Cogn Neurosci. 2018 11; 34:34-41.
Vandenberg A, Lin WC, Tai LH, Ron D, Wilbrecht L. PMID: 29909248; PMCID: PMC6596311.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
GDNF and alcohol use disorder. Addict Biol. 2019 05; 24(3):335-343.
Barak S, Ahmadiantehrani S, Logrip ML, Ron D. PMID: 29726054; PMCID: PMC6215739.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders. Psychopharmacology (Berl). 2018 06; 235(6):1727-1743.
Ron D, Berger A. PMID: 29654346; PMCID: PMC5949137.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. Neuropsychopharmacology. 2018 06; 43(7):1539-1547.
Laguesse S, Morisot N, Phamluong K, Sakhai SA, Ron D. PMID: 29497165; PMCID: PMC5983552.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. Mol Psychiatry. 2018 01; 23(1):164.
Liu F, Laguesse S, Legastelois R, Morisot N, Ben Hamida S, Ron D. PMID: 29133951; PMCID: PMC5754470.
View in:
PubMed Mentions:
3 Fields:
-
Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron. 2017 Sep 27; 96(1):145-159.e8.
Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC, Becker HC, Bender KJ, Alvarez VA, Ron D. PMID: 28890345; PMCID: PMC6014831.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum. Front Mol Neurosci. 2017; 10:273.
Phamluong K, Darcq E, Wu S, Sakhai SA, Ron D. PMID: 28912680; PMCID: PMC5583218.
View in:
PubMed Mentions:
5
-
Alcohol operant self-administration: Investigating how alcohol-seeking behaviors predict drinking in mice using two operant approaches. Alcohol. 2018 03; 67:23-36.
Blegen MB, da Silva E Silva D, Bock R, Morisot N, Ron D, Alvarez VA. PMID: 29310048; PMCID: PMC5939586.
View in:
PubMed Mentions:
22 Fields:
Translation:
Animals
-
A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addict Biol. 2018 03; 23(2):713-722.
Morisot N, Novotny CJ, Shokat KM, Ron D. PMID: 28681511.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment. Cell Rep. 2017 07 05; 20(1):21-29.
Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ. PMID: 28683314; PMCID: PMC6483373.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
mTORC1 is a key molecular transducer of alcohol-dependent plasticity, seeking and relapse. Alcohol. 2017 May 1; 60:205-206.
Ron RD. .
View in:
Publisher Site Mentions:
-
Altered sensitivity to the anxiolytic and rewarding properties of alcohol in mice which carry the BDNF valine 68 to methionine polymorphism. Alcohol. 2017 May 1; 60:232-233.
Sakhai SS, Morisot MN, Ron RD. .
View in:
Publisher Site Mentions:
-
Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 02; 41(2):345-358.
Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW. PMID: 28103636; PMCID: PMC5636002.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Alcohol-dependent molecular adaptations of the NMDA receptor system. Genes Brain Behav. 2017 Jan; 16(1):139-148.
Morisot N, Ron D. PMID: 27906494; PMCID: PMC5444330.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
-
Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol. 2017 Nov; 22(6):1856-1869.
Laguesse S, Morisot N, Phamluong K, Ron D. PMID: 27766766; PMCID: PMC5398951.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci. 2016 09 28; 36(39):10116-27.
Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. PMID: 27683907; PMCID: PMC5039257.
View in:
PubMed Mentions:
26 Fields:
Translation:
Animals
-
Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter. PLoS One. 2016; 11(8):e0160948.
Neasta J, Fiorenza A, He DY, Phamluong K, Kiely PA, Ron D. PMID: 27505161; PMCID: PMC4978483.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Molecular mechanisms underlying alcohol-drinking behaviours. Nat Rev Neurosci. 2016 09; 17(9):576-91.
Ron D, Barak S. PMID: 27444358; PMCID: PMC5131788.
View in:
PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
-
The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci. 2016 Jan 20; 36(3):701-13.
Beckley JT, Laguesse S, Phamluong K, Morisot N, Wegner SA, Ron D. PMID: 26791202; PMCID: PMC4719011.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Chapter 13 mTOR and Drugs of Abuse. Molecules to Medicine with mTOR. 2016 Jan 1; 215-226.
Beckley BJ, Ron RD. .
View in:
Publisher Site Mentions:
-
Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J Neurosci. 2015 Aug 19; 35(33):11634-43.
Wang J, Cheng Y, Wang X, Roltsch Hellard E, Ma T, Gil H, Ben Hamida S, Ron D. PMID: 26290240; PMCID: PMC4540799.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
-
The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15; 79(6):463-73.
Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. PMID: 26204799; PMCID: PMC4676961.
View in:
PubMed Mentions:
52 Fields:
Translation:
Animals
-
Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. PLoS One. 2015; 10(5):e0127408.
Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. PMID: 25992601; PMCID: PMC4438985.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Corticostriatal BDNF and alcohol addiction. Brain Res. 2015 Dec 02; 1628(Pt A):60-7.
Logrip ML, Barak S, Warnault V, Ron D. PMID: 25801118; PMCID: PMC4577309.
View in:
PubMed Mentions:
60 Fields:
Translation:
Animals
-
Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Addict Biol. 2015 Jul; 20(4):629-42.
Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D. PMID: 24801661.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem. 2014 Jul; 130(2):172-84.
Neasta J, Barak S, Hamida SB, Ron D. PMID: 24666346; PMCID: PMC4107045.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
-
Animal models of excessive alcohol consumption: recent advances and future challenges. Alcohol. 2014 May; 48(3):205-8.
Becker HC, Ron D. PMID: 24811154; PMCID: PMC5081257.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. J Neurochem. 2014 Jun; 129(6):1024-34.
Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. PMID: 24588427; PMCID: PMC4055745.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014 May; 48(3):243-52.
Carnicella S, Ron D, Barak S. PMID: 24721195; PMCID: PMC4102254.
View in:
PubMed Mentions:
147 Fields:
Translation:
Animals
-
Chapter 9 From Signaling Pathways to Behavior The Light and Dark Sides of Alcohol. Neurobiology of Alcohol Dependence. 2014 Jan 1; 155-171.
Ahmadiantehrani AS, Warnault WV, Legastelois LR, Ron RD. .
View in:
Publisher Site Mentions:
-
Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov; 5(17):2011-3.
Warnault V, Ron D. PMID: 24215342; PMCID: PMC4072217.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. J Neurosci. 2013 Sep 04; 33(36):14369-78.
Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D. PMID: 24005290; PMCID: PMC3761047.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
RACK1 to the future--a historical perspective. Cell Commun Signal. 2013 Aug 01; 11:53.
Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. PMID: 23915285; PMCID: PMC3750812.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
-
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug; 16(8):1094-100.
Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. PMID: 23817545; PMCID: PMC3939030.
View in:
PubMed Mentions:
183 Fields:
Translation:
Animals
-
Nature Neurosci June 3, 2013 [epub ahead of print]. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. 2013.
Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH and Ron D.
-
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug; 16(8):1111-7.
Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. PMID: 23792945; PMCID: PMC3725202.
View in:
PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
-
Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct; 37(10):1680-7.
Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. PMID: 23763790; PMCID: PMC3985436.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem. 2013 Apr; 125(2):193-204.
Ahmadiantehrani S, Ron D. PMID: 23373701; PMCID: PMC3672320.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
-
GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul; 19(4):623-33.
Ahmadiantehrani S, Barak S, Ron D. PMID: 23298382; PMCID: PMC3626755.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Addiction Biology January 9, 2013 [epub ahead of print]. GDNF is a novel ethanol-responsive gene in the VTA: Implications for the development and persistence of excessive drinking. 2013.
Ahmadiantehrani S, Barak S and Ron D.
-
J Neurochem. Dopamine D2 receptor activation leads to an upregulation of glial cell line-derived neurotrophic factor via Gbetagamma-Erk1/2-dependent induction of Zif268. 2013; 125:193-204.
Ahmadiantehrani S and Ron D. View Publication.
-
Transl Psychiatry. Chromatin remodeling - A novel strategy to control excessive alcohol drinking. 2013; e231(3).
Warnault V, Darcq E, Levine A, Barak S, Ron D. View Publication.
-
Alcohol: Clin Exp Res. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. 2013; 37:8-15.
Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW.
-
BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb; 37(4):607-12.
Jeanblanc J, Logrip ML, Janak PH, Ron D. PMID: 23189980; PMCID: PMC3577946.
View in:
PubMed Mentions:
38 Translation:
AnimalsCells
-
Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. J Neurosci. 2012 Oct 24; 32(43):15124-32.
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, Ron D. PMID: 23100433; PMCID: PMC3498079.
View in:
PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
-
Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan; 37(1):8-15.
Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. PMID: 22671690; PMCID: PMC3443504.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Signaling pathways mediating alcohol effects. 2012; 13:87-126.
Ron D, Messing RO.
-
Addic Biol. Alpha4 subunit-containing GABA(A) receptors in the accumbens shell contribute to the reinforcing effects of alcohol. 2012; 17:309-21.
Rewal M, Donahue R, Gill TM, Nie H, Ron D, Janak PH.
-
J Neurosci. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. 2012; 32:15849-15858.
Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D. View Publication.
-
J Neurosci. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: Implications for alcohol drinking behavior. 2012; 32:15124-15132.
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S and Ron D.
-
J Biol Chem. Direct interaction between scaffolding proteins RACK1 and 14-3-3zeta regulates brain-derived neurotrophic factor (BDNF) transcription. 2012; 287:322-36.
Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D.
-
RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal. 2011 Oct 06; 9:22.
Adams DR, Ron D, Kiely PA. PMID: 21978545; PMCID: PMC3195729.
View in:
PubMed Mentions:
229 Fields:
-
Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J Neurosci. 2011 Jul 06; 31(27):9885-94.
Barak S, Carnicella S, Yowell QV, Ron D. PMID: 21734280; PMCID: PMC3144766.
View in:
PubMed Mentions:
48 Fields:
Translation:
Animals
-
Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcohol Clin Exp Res. 2011 Oct; 35(10):1739-48.
Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. PMID: 21615425; PMCID: PMC3276303.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimals
-
AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biol Psychiatry. 2011 Sep 15; 70(6):575-82.
Neasta J, Ben Hamida S, Yowell QV, Carnicella S, Ron D. PMID: 21549353; PMCID: PMC3228847.
View in:
PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
-
Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-Jun; 5(3):205-9.
Wang J, Lanfranco MF, Gibb SL, Ron D. PMID: 21289476; PMCID: PMC3225747.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4459-64.
Nie H, Rewal M, Gill TM, Ron D, Janak PH. PMID: 21368141; PMCID: PMC3060220.
View in:
PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
-
Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J Neurosci. 2011 Feb 09; 31(6):2180-7.
Gibb SL, Jeanblanc J, Barak S, Yowell QV, Yaka R, Ron D. PMID: 21307254; PMCID: PMC6633047.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
Signaling Pathways Mediating Alcohol Effects. Behavioral Neurobiology of Alcohol Addiction. 2011 Jan 1; 13:87-126.
Ron RD, Messing MR. .
View in:
Publisher Site Mentions:
-
J Neurochem. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase alpha. 2011; 119:879-89.
Gibb SL, Ben Hamida S, Lanfranco MF, Ron D.
-
J Neurochem. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase alpha. 2011; 119:879-89.
Gibb SL, Hamida SB, Lanfranco MF, Ron D.
-
Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20093-8.
Neasta J, Ben Hamida S, Yowell Q, Carnicella S, Ron D. PMID: 21041654; PMCID: PMC2993345.
View in:
PubMed Mentions:
80 Fields:
Translation:
AnimalsCells
-
Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system. J Neurosci. 2010 Oct 27; 30(43):14502-12.
Wang J, Carnicella S, Ahmadiantehrani S, He DY, Barak S, Kharazia V, Ben Hamida S, Zapata A, Shippenberg TS, Ron D. PMID: 20980608; PMCID: PMC2981598.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
-
Regulation of operant oral ethanol self-administration: a dose-response curve study in rats. Alcohol Clin Exp Res. 2011 Jan; 35(1):116-25.
Carnicella S, Yowell QV, Ron D. PMID: 21039633; PMCID: PMC3058717.
View in:
PubMed Mentions:
15 Fields:
Translation:
Animals
-
Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. Addict Biol. 2010 Oct; 15(4):424-33.
Carnicella S, He DY, Yowell QV, Glick SD, Ron D. PMID: 21040239; PMCID: PMC3783954.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse. J Neurosci. 2010 Jul 28; 30(30):10187-98.
Wang J, Lanfranco MF, Gibb SL, Yowell QV, Carnicella S, Ron D. PMID: 20668202; PMCID: PMC2950094.
View in:
PubMed Mentions:
118 Fields:
Translation:
AnimalsCells
-
Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18; 285(25):19043-50.
He DY, Neasta J, Ron D. PMID: 20410295; PMCID: PMC2885182.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
-
Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci. 2009 Oct 28; 29(43):13494-502.
Jeanblanc J, He DY, Carnicella S, Kharazia V, Janak PH, Ron D. PMID: 19864562; PMCID: PMC2855618.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansAnimalsCells
-
Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug; 43(5):359-65.
Logrip ML, Janak PH, Ron D. PMID: 19671462; PMCID: PMC3784271.
View in:
PubMed Mentions:
34 Fields:
Translation:
Animals
-
Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem. 2009 Jun; 109(5):1459-68.
Logrip ML, Janak PH, Ron D. PMID: 19453942; PMCID: PMC2847400.
View in:
PubMed Mentions:
60 Fields:
Translation:
Animals
-
GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun; 33(6):1012-24.
Carnicella S, Ahmadiantehrani S, Janak PH, Ron D. PMID: 19302086; PMCID: PMC2789657.
View in:
PubMed Mentions:
23 Fields:
Translation:
Animals
-
Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15; 66(2):146-53.
Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH, Ron D. PMID: 19232578; PMCID: PMC2895406.
View in:
PubMed Mentions:
20 Fields:
Translation:
Animals
-
Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol. 2009 Feb; 43(1):35-43.
Carnicella S, Amamoto R, Ron D. PMID: 19185208; PMCID: PMC2789656.
View in:
PubMed Mentions:
66 Fields:
Translation:
Animals
-
Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci. 2009 Jan 14; 29(2):543-9.
Rewal M, Jurd R, Gill TM, He DY, Ron D, Janak PH. PMID: 19144854; PMCID: PMC2768359.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
-
GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr; 122(1):9-18.
Carnicella S, Ron D. PMID: 19136027; PMCID: PMC3682485.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
-
PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 01; 415(1):77-85.
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PMID: 18557705.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
-
GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8114-9.
Carnicella S, Kharazia V, Jeanblanc J, Janak PH, Ron D. PMID: 18541917; PMCID: PMC2423415.
View in:
PubMed Mentions:
72 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. J Biol Chem. 2008 May 09; 283(19):12811-8.
He DY, Ron D. PMID: 18343820; PMCID: PMC2442340.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. FASEB J. 2008 Jul; 22(7):2393-404.
Logrip ML, Janak PH, Ron D. PMID: 18310464.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
-
Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem. 2008 Jan 04; 283(1):301-310.
Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb SL, Ron D. PMID: 17962190; PMCID: PMC3124443.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
-
Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun; 55(6):570-7.
Newton PM, Ron D. PMID: 17566760.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimals
-
Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci. 2007 Mar 28; 27(13):3593-602.
Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, Janak PH, Lovinger DM, Ron D. PMID: 17392475; PMCID: PMC6672130.
View in:
PubMed Mentions:
115 Fields:
Translation:
AnimalsCells
-
Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. FASEB J. 2006 Nov; 20(13):2420-2.
He DY, Ron D. PMID: 17023388.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
-
Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci. 2006 Aug 16; 26(33):8549-58.
Schilström B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D, Bonci A. PMID: 16914681; PMCID: PMC6674361.
View in:
PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
-
Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol Cell Biol. 2006 Jun; 26(11):4041-51.
Kiely PA, O'Gorman D, Luong K, Ron D, O'Connor R. PMID: 16705158; PMCID: PMC1489096.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
-
Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr; 31(4):768-77.
Szumlinski KK, Abernathy KE, Oleson EB, Klugmann M, Lominac KD, He DY, Ron D, During M, Kalivas PW. PMID: 16160706.
View in:
PubMed Mentions:
46 Fields:
Translation:
Animals
-
The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci. 2006 Feb 01; 26(5):1457-64.
Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D. PMID: 16452669; PMCID: PMC6675490.
View in:
PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
-
BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res. 2006 Feb; 30(2):214-21.
Janak PH, Wolf FW, Heberlein U, Pandey SC, Logrip ML, Ron D. PMID: 16441270.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
-
From blue states to up states: a regional view of NMDA-ethanol interactions. Alcohol Clin Exp Res. 2006 Feb; 30(2):359-67.
Woodward JJ, Ron D, Winder D, Roberto M. PMID: 16441285.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
The "ups and downs" of signaling cascades in addiction. Sci STKE. 2005 Nov 08; 2005(309):re14.
Ron D, Jurd R. PMID: 16278489.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem. 2005 Sep 09; 280(36):31450-9.
Suvarna N, Borgland SL, Wang J, Phamluong K, Auberson YP, Bonci A, Ron D. PMID: 16009711.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J Neurosci. 2005 Jan 19; 25(3):619-28.
He DY, McGough NN, Ravindranathan A, Jeanblanc J, Logrip ML, Phamluong K, Janak PH, Ron D. PMID: 15659598; PMCID: PMC1193648.
View in:
PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
-
GDNF and addiction. Rev Neurosci. 2005; 16(4):277-85.
Ron D, Janak PH. PMID: 16519005.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci. 2004 Nov 17; 24(46):10542-52.
McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. PMID: 15548669; PMCID: PMC6730316.
View in:
PubMed Mentions:
120 Fields:
Translation:
AnimalsCells
-
Signaling cascades regulating NMDA receptor sensitivity to ethanol. Neuroscientist. 2004 Aug; 10(4):325-36.
Ron D. PMID: 15271260; PMCID: PMC1361309.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
-
Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biol Chem. 2004 Jul 23; 279(30):31357-64.
Thornton C, Tang KC, Phamluong K, Luong K, Vagts A, Nikanjam D, Yaka R, Ron D. PMID: 15140893.
View in:
PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
-
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcohol Clin Exp Res. 2003 Nov; 27(11):1736-42.
Yaka R, Tang KC, Camarini R, Janak PH, Ron D. PMID: 14634488; PMCID: PMC1193705.
View in:
PubMed Mentions:
49 Fields:
Translation:
Animals
-
Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcohol Clin Exp Res. 2003 Oct; 27(10):1599-605.
Vagts AJ, He DY, Yaka R, Ron D. PMID: 14574230.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron. 2003 Jul 31; 39(3):401-7.
Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. PMID: 12895416.
View in:
PubMed Mentions:
164 Fields:
Translation:
AnimalsCells
-
Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci. 2003 May 01; 23(9):3623-32.
Yaka R, Phamluong K, Ron D. PMID: 12736333; PMCID: PMC1262669.
View in:
PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
-
H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biol Chem. 2003 Jun 27; 278(26):23823-9.
Thornton C, Yaka R, Dinh S, Ron D. PMID: 12695509; PMCID: PMC1196389.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003 Mar 14; 278(11):9630-8.
Yaka R, He DY, Phamluong K, Ron D. PMID: 12524444.
View in:
PubMed Mentions:
80 Fields:
Translation:
AnimalsCells
-
Glutathione S-transferase pull-down assay. Methods Mol Biol. 2003; 233:345-50.
Schechtman D, Mochly-Rosen D, Ron D. PMID: 12840520.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Alcohol addiction. Methods Mol Biol. 2003; 233:555-70.
Olive MF, Ron D. PMID: 12840534.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Ethanol induces gene expression via nuclear compartmentalization of receptor for activated C kinase 1. Mol Pharmacol. 2002 Aug; 62(2):272-80.
He DY, Vagts AJ, Yaka R, Ron D. PMID: 12130678.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5710-5.
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. PMID: 11943848; PMCID: PMC122836.
View in:
PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells