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Dorit Ron, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Phone415-502-7068
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    The Hebrew University of Jerusalem, Jerusalem, IsraelPh.D.1990Pharmacology
    Stanford University, Stanford, CA1995Postdoctoral training
    Collapse Awards and Honors
    NIH2013  - 2023Merit Award

    Collapse Overview 
    Collapse Overview
    Dr. Ron is a Professor in the Department of Neurology at UCSF, and is a member of the Neuroscience Graduate Program. She is also the Endowed Chair in Cell Biology of Addiction in Neurology at UCSF, the Director for a P50 NIH-NIAAA Center Grant. She is a recipient of several NIH RO1 and DOD grant awards. In 2013, Dr. Ron received and NIH MERIT. She has served as an Associate Editor for the Journal of Neuroscience and is currently a reviewing editor for Addiction Biology, the Alcohol Journal, as well as a field editor for Alcoholism: Clinical and Experimental Research. Dr. Ron’s research focuses on the molecular neurobiology of alcohol use disorders for which her laboratory uses molecular, and rodent behavior approaches. Dr. Ron’s areas of expertise are: molecular neuroscience, signal transduction, neurobiology of addiction and psychiatric disorders. Over the years the Ron lab has made numerous major contributions to the field of addiction and identified novel targets that could potentially be developed as therapeutics to treat alcohol addiction. Several of the studies resulted in UCSF press releases, which received the attention of both the scientific community and the general public.

    Collapse Research 
    Collapse Research Activities and Funding
    Small G proteins and alcohol use disorder
    NIH/NIAAA R01AA027682Sep 1, 2019 - Jul 31, 2024
    Role: Principal Investigator
    Adolescent alcohol drinking and GABA signaling
    NIH/NIAAA R01AA027023Apr 12, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    mTOR Signaling and Alcohol Use Disorder
    NIH/NIAAA R01AA027474Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Pathway-specific Fyn signaling in the striatum and ethanol drinking
    NIH/NIAAA UO1AA023489AOct 1, 2014 - Aug 31, 2019
    Role: Principal Investigator
    BDNF and Alcohol Addiction
    NIH/NIAAA R37AA016848-05Apr 1, 2013 - Jun 30, 2023
    Role: Principal Investigator
    PI3K/AKT/mTOR Signaling Pathways in Models of Binge Drinking and Relapse
    NIH/NIAAA P50AA017072-06Aug 1, 2008 - Jun 30, 2018
    Role: Principal Investigator
    Alcohol Center for Translational Genetics (ACTG)
    NIH/NIAAA P50AA017072-06Aug 1, 2008 - Jun 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Astrocytes and alcohol: cortical astrocytes regulate alcohol consumption and intoxication. Neuropsychopharmacology. 2020 Jun 19. Moffat JJ, Ron D. PMID: 32561855.
      View in: PubMed   Mentions:    Fields:    
    2. cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use. Neuropsychopharmacology. 2020 May 17. Ehinger Y, Morisot N, Phamluong K, Sakhai SA, Soneja D, Adrover MF, Alvarez VA, Ron D. PMID: 32417851.
      View in: PubMed   Mentions:    Fields:    
    3. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Addict Biol. 2020 Mar 05; e12890. Ehinger Y, Phamluong K, Darevesky D, Welman M, Moffat JJ, Sakhai SA, Whiteley EL, Berger AL, Laguesse S, Farokhnia M, Leggio L, Lordkipanidzé M, Ron D. PMID: 32135570.
      View in: PubMed   Mentions:    Fields:    
    4. Growth Factors and Alcohol Use Disorder. Cold Spring Harb Perspect Med. 2020 Jan 21. Liran M, Rahamim N, Ron D, Barak S. PMID: 31964648.
      View in: PubMed   Mentions:    Fields:    
    5. mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking. Elife. 2019 12 11; 8. Morisot N, Phamluong K, Ehinger Y, Berger AL, Moffat JJ, Ron D. PMID: 31820733.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking. eLife. 2019 Dec 10; 8:e51333. Nadege Morisot, Khanhky Phamluong, Yann Ehinger, Anthony L Berger, Jeffrey J Moffat, Dorit Ron. .
      View in: Publisher Site   Mentions:
    7. Protein Translation and Psychiatric Disorders. Neuroscientist. 2020 Feb; 26(1):21-42. Laguesse S, Ron D. PMID: 31271100.
      View in: PubMed   Mentions:    Fields:    
    8. The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking. Addict Biol. 2019 11; 24(6):1227-1234. Morisot N, Berger AL, Phamluong K, Cross A, Ron D. PMID: 30536923.
      View in: PubMed   Mentions:    Fields:    
    9. D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors. Neuropsychopharmacology. 2019 03; 44(4):805-816. Dobbs LK, Kaplan AR, Bock R, Phamluong K, Shin JH, Bocarsly ME, Eberhart L, Ron D, Alvarez VA. PMID: 30504927.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. 2018 09 15; 140:35-42. Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC. PMID: 30056122.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking. Addict Biol. 2019 09; 24(5):908-920. Ben Hamida S, Laguesse S, Morisot N, Park JH, Phuamluong K, Berger AL, Park KD, Ron D. PMID: 30022576.
      View in: PubMed   Mentions: 2     Fields:    
    12. Special issue on new technologies for alcohol research and treatment. Alcohol. 2019 02; 74:1-2. Ron D, Weiner J. PMID: 30409742.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies. Dev Cogn Neurosci. 2018 11; 34:34-41. Vandenberg A, Lin WC, Tai LH, Ron D, Wilbrecht L. PMID: 29909248.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    14. GDNF and alcohol use disorder. Addict Biol. 2019 05; 24(3):335-343. Barak S, Ahmadiantehrani S, Logrip ML, Ron D. PMID: 29726054.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders. Psychopharmacology (Berl). 2018 06; 235(6):1727-1743. Ron D, Berger A. PMID: 29654346.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. Neuropsychopharmacology. 2018 06; 43(7):1539-1547. Laguesse S, Morisot N, Phamluong K, Sakhai SA, Ron D. PMID: 29497165.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. Mol Psychiatry. 2018 01; 23(1):164. Liu F, Laguesse S, Legastelois R, Morisot N, Ben Hamida S, Ron D. PMID: 29133951.
      View in: PubMed   Mentions:    Fields:    
    18. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron. 2017 Sep 27; 96(1):145-159.e8. Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC, Becker HC, Bender KJ, Alvarez VA, Ron D. PMID: 28890345.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    19. Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum. Front Mol Neurosci. 2017; 10:273. Phamluong K, Darcq E, Wu S, Sakhai SA, Ron D. PMID: 28912680.
      View in: PubMed   Mentions:
    20. Alcohol operant self-administration: Investigating how alcohol-seeking behaviors predict drinking in mice using two operant approaches. Alcohol. 2018 03; 67:23-36. Blegen MB, da Silva E Silva D, Bock R, Morisot N, Ron D, Alvarez VA. PMID: 29310048.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addict Biol. 2018 03; 23(2):713-722. Morisot N, Novotny CJ, Shokat KM, Ron D. PMID: 28681511.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    22. Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment. Cell Rep. 2017 07 05; 20(1):21-29. Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ. PMID: 28683314.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Altered sensitivity to the anxiolytic and rewarding properties of alcohol in mice which carry the BDNF valine 68 to methionine polymorphism. Alcohol. 2017 May 1; 60:232-233. Samuel A. Sakhai, Nadege Morisot, Dorit Ron. .
      View in: Publisher Site   Mentions:
    24. mTORC1 is a key molecular transducer of alcohol-dependent plasticity, seeking and relapse. Alcohol. 2017 May 1; 60:205-206. Dorit Ron. .
      View in: Publisher Site   Mentions:
    25. Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 02; 41(2):345-358. Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW. PMID: 28103636.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Alcohol-dependent molecular adaptations of the NMDA receptor system. Genes Brain Behav. 2017 Jan; 16(1):139-148. Morisot N, Ron D. PMID: 27906494.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol. 2017 Nov; 22(6):1856-1869. Laguesse S, Morisot N, Phamluong K, Ron D. PMID: 27766766.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci. 2016 09 28; 36(39):10116-27. Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. PMID: 27683907.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    29. Activation of the cAMP Pathway Induces RACK1-Dependent Binding of ß-Actin to BDNF Promoter. PLoS One. 2016; 11(8):e0160948. Neasta J, Fiorenza A, He DY, Phamluong K, Kiely PA, Ron D. PMID: 27505161.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Molecular mechanisms underlying alcohol-drinking behaviours. Nat Rev Neurosci. 2016 09; 17(9):576-91. Ron D, Barak S. PMID: 27444358.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    31. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci. 2016 Jan 20; 36(3):701-13. Beckley JT, Laguesse S, Phamluong K, Morisot N, Wegner SA, Ron D. PMID: 26791202.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    32. Chapter 13 mTOR and Drugs of Abuse. Molecules to Medicine with mTOR. 2016 Jan 1; 215-226. Jacob T. Beckley, Dorit Ron. .
      View in: Publisher Site   Mentions:
    33. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J Neurosci. 2015 Aug 19; 35(33):11634-43. Wang J, Cheng Y, Wang X, Roltsch Hellard E, Ma T, Gil H, Ben Hamida S, Ron D. PMID: 26290240.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    34. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15; 79(6):463-73. Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. PMID: 26204799.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    35. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. PLoS One. 2015; 10(5):e0127408. Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. PMID: 25992601.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    36. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015 Dec 02; 1628(Pt A):60-7. Logrip ML, Barak S, Warnault V, Ron D. PMID: 25801118.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    37. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Addict Biol. 2015 Jul; 20(4):629-42. Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D. PMID: 24801661.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem. 2014 Jul; 130(2):172-84. Neasta J, Barak S, Hamida SB, Ron D. PMID: 24666346.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    39. Animal models of excessive alcohol consumption: recent advances and future challenges. Alcohol. 2014 May; 48(3):205-8. Becker HC, Ron D. PMID: 24811154.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    40. Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. J Neurochem. 2014 Jun; 129(6):1024-34. Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. PMID: 24588427.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014 May; 48(3):243-52. Carnicella S, Ron D, Barak S. PMID: 24721195.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    42. Chapter 9 From Signaling Pathways to Behavior The Light and Dark Sides of Alcohol. Neurobiology of Alcohol Dependence. 2014 Jan 1; 155-171. Somayeh Ahmadiantehrani, Vincent Warnault, Remi Legastelois, Dorit Ron. .
      View in: Publisher Site   Mentions:
    43. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov; 5(17):2011-3. Warnault V, Ron D. PMID: 24215342.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    44. Protein tyrosine phosphatase a in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. J Neurosci. 2013 Sep 04; 33(36):14369-78. Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D. PMID: 24005290.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    45. RACK1 to the future--a historical perspective. Cell Commun Signal. 2013 Aug 01; 11:53. Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. PMID: 23915285.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug; 16(8):1094-100. Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. PMID: 23817545.
      View in: PubMed   Mentions: 88     Fields:    Translation:Animals
    47. Nature Neurosci June 3, 2013 [epub ahead of print]. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. 2013. Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH and Ron D..
    48. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug; 16(8):1111-7. Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. PMID: 23792945.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    49. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct; 37(10):1680-7. Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. PMID: 23763790.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    50. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gß?-Erk1/2-dependent induction of Zif268. J Neurochem. 2013 Apr; 125(2):193-204. Ahmadiantehrani S, Ron D. PMID: 23373701.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    51. GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul; 19(4):623-33. Ahmadiantehrani S, Barak S, Ron D. PMID: 23298382.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    52. Addiction Biology January 9, 2013 [epub ahead of print]. GDNF is a novel ethanol-responsive gene in the VTA: Implications for the development and persistence of excessive drinking. 2013. Ahmadiantehrani S, Barak S and Ron D..
    53. J Neurochem. Dopamine D2 receptor activation leads to an upregulation of glial cell line-derived neurotrophic factor via Gbetagamma-Erk1/2-dependent induction of Zif268. 2013; 125:193-204. View Publication.
    54. Transl Psychiatry. Chromatin remodeling - A novel strategy to control excessive alcohol drinking. 2013; e231(3). View Publication.
    55. Alcohol: Clin Exp Res. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. 2013; 37:8-15. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW.
    56. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb; 37(4):607-12. Jeanblanc J, Logrip ML, Janak PH, Ron D. PMID: 23189980.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. J Neurosci. 2012 Oct 24; 32(43):15124-32. Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, Ron D. PMID: 23100433.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    58. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan; 37(1):8-15. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. PMID: 22671690.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    59. J Neurosci. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. 2012; 32:15849-15858. View Publication.
    60. Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Signaling pathways mediating alcohol effects. 2012; 13:87-126. Ron D, Messing RO.
    61. J Neurosci. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: Implications for alcohol drinking behavior. 2012; 32:15124-15132. Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S and Ron D..
    62. Addic Biol. Alpha4 subunit-containing GABA(A) receptors in the accumbens shell contribute to the reinforcing effects of alcohol. 2012; 17:309-21. Rewal M, Donahue R, Gill TM, Nie H, Ron D, Janak PH.
    63. J Biol Chem. Direct interaction between scaffolding proteins RACK1 and 14-3-3zeta regulates brain-derived neurotrophic factor (BDNF) transcription. 2012; 287:322-36. Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D..
    64. RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal. 2011 Oct 06; 9:22. Adams DR, Ron D, Kiely PA. PMID: 21978545.
      View in: PubMed   Mentions: 124     Fields:    
    65. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J Neurosci. 2011 Jul 06; 31(27):9885-94. Barak S, Carnicella S, Yowell QV, Ron D. PMID: 21734280.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    66. Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcohol Clin Exp Res. 2011 Oct; 35(10):1739-48. Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. PMID: 21615425.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    67. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biol Psychiatry. 2011 Sep 15; 70(6):575-82. Neasta J, Ben Hamida S, Yowell QV, Carnicella S, Ron D. PMID: 21549353.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    68. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-Jun; 5(3):205-9. Wang J, Lanfranco MF, Gibb SL, Ron D. PMID: 21289476.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    69. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4459-64. Nie H, Rewal M, Gill TM, Ron D, Janak PH. PMID: 21368141.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    70. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J Neurosci. 2011 Feb 09; 31(6):2180-7. Gibb SL, Jeanblanc J, Barak S, Yowell QV, Yaka R, Ron D. PMID: 21307254.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    71. Signaling Pathways Mediating Alcohol Effects. Behavioral Neurobiology of Alcohol Addiction. 2011 Jan 1; 13:87-126. Dorit Ron, Robert O. Messing. .
      View in: Publisher Site   Mentions:
    72. J Neurochem. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase alpha. 2011; 119:879-89. Gibb SL, Ben Hamida S, Lanfranco MF, Ron D..
    73. J Neurochem. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase alpha. 2011; 119:879-89. Gibb SL, Hamida SB, Lanfranco MF, Ron D..
    74. Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20093-8. Neasta J, Ben Hamida S, Yowell Q, Carnicella S, Ron D. PMID: 21041654.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    75. Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system. J Neurosci. 2010 Oct 27; 30(43):14502-12. Wang J, Carnicella S, Ahmadiantehrani S, He DY, Barak S, Kharazia V, Ben Hamida S, Zapata A, Shippenberg TS, Ron D. PMID: 20980608.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    76. Regulation of operant oral ethanol self-administration: a dose-response curve study in rats. Alcohol Clin Exp Res. 2011 Jan; 35(1):116-25. Carnicella S, Yowell QV, Ron D. PMID: 21039633.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    77. Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. Addict Biol. 2010 Oct; 15(4):424-33. Carnicella S, He DY, Yowell QV, Glick SD, Ron D. PMID: 21040239.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    78. Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse. J Neurosci. 2010 Jul 28; 30(30):10187-98. Wang J, Lanfranco MF, Gibb SL, Yowell QV, Carnicella S, Ron D. PMID: 20668202.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    79. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18; 285(25):19043-50. He DY, Neasta J, Ron D. PMID: 20410295.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    80. Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci. 2009 Oct 28; 29(43):13494-502. Jeanblanc J, He DY, Carnicella S, Kharazia V, Janak PH, Ron D. PMID: 19864562.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    81. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug; 43(5):359-65. Logrip ML, Janak PH, Ron D. PMID: 19671462.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    82. Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem. 2009 Jun; 109(5):1459-68. Logrip ML, Janak PH, Ron D. PMID: 19453942.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    83. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun; 33(6):1012-24. Carnicella S, Ahmadiantehrani S, Janak PH, Ron D. PMID: 19302086.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    84. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15; 66(2):146-53. Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH, Ron D. PMID: 19232578.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    85. Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol. 2009 Feb; 43(1):35-43. Carnicella S, Amamoto R, Ron D. PMID: 19185208.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    86. Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci. 2009 Jan 14; 29(2):543-9. Rewal M, Jurd R, Gill TM, He DY, Ron D, Janak PH. PMID: 19144854.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    87. GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr; 122(1):9-18. Carnicella S, Ron D. PMID: 19136027.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    88. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 01; 415(1):77-85. Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PMID: 18557705.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    89. GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8114-9. Carnicella S, Kharazia V, Jeanblanc J, Janak PH, Ron D. PMID: 18541917.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCellsPHPublic Health
    90. Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. J Biol Chem. 2008 May 09; 283(19):12811-8. He DY, Ron D. PMID: 18343820.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    91. Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. FASEB J. 2008 Jul; 22(7):2393-404. Logrip ML, Janak PH, Ron D. PMID: 18310464.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    92. Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem. 2008 Jan 04; 283(1):301-10. Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb SL, Ron D. PMID: 17962190.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    93. Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun; 55(6):570-7. Newton PM, Ron D. PMID: 17566760.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    94. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci. 2007 Mar 28; 27(13):3593-602. Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, Janak PH, Lovinger DM, Ron D. PMID: 17392475.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    95. Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. FASEB J. 2006 Nov; 20(13):2420-2. He DY, Ron D. PMID: 17023388.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    96. Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci. 2006 Aug 16; 26(33):8549-58. Schilström B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D, Bonci A. PMID: 16914681.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    97. Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol Cell Biol. 2006 Jun; 26(11):4041-51. Kiely PA, O'Gorman D, Luong K, Ron D, O'Connor R. PMID: 16705158.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    98. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr; 31(4):768-77. Szumlinski KK, Abernathy KE, Oleson EB, Klugmann M, Lominac KD, He DY, Ron D, During M, Kalivas PW. PMID: 16160706.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    99. BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res. 2006 Feb; 30(2):214-21. Janak PH, Wolf FW, Heberlein U, Pandey SC, Logrip ML, Ron D. PMID: 16441270.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    100. The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci. 2006 Feb 01; 26(5):1457-64. Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D. PMID: 16452669.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    101. From blue states to up states: a regional view of NMDA-ethanol interactions. Alcohol Clin Exp Res. 2006 Feb; 30(2):359-67. Woodward JJ, Ron D, Winder D, Roberto M. PMID: 16441285.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    102. The "ups and downs" of signaling cascades in addiction. Sci STKE. 2005 Nov 08; 2005(309):re14. Ron D, Jurd R. PMID: 16278489.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    103. Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem. 2005 Sep 09; 280(36):31450-9. Suvarna N, Borgland SL, Wang J, Phamluong K, Auberson YP, Bonci A, Ron D. PMID: 16009711.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    104. Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J Neurosci. 2005 Jan 19; 25(3):619-28. He DY, McGough NN, Ravindranathan A, Jeanblanc J, Logrip ML, Phamluong K, Janak PH, Ron D. PMID: 15659598.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    105. GDNF and addiction. Rev Neurosci. 2005; 16(4):277-85. Ron D, Janak PH. PMID: 16519005.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    106. RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci. 2004 Nov 17; 24(46):10542-52. McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. PMID: 15548669.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    107. Signaling cascades regulating NMDA receptor sensitivity to ethanol. Neuroscientist. 2004 Aug; 10(4):325-36. Ron D. PMID: 15271260.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    108. Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biol Chem. 2004 Jul 23; 279(30):31357-64. Thornton C, Tang KC, Phamluong K, Luong K, Vagts A, Nikanjam D, Yaka R, Ron D. PMID: 15140893.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    109. Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcohol Clin Exp Res. 2003 Nov; 27(11):1736-42. Yaka R, Tang KC, Camarini R, Janak PH, Ron D. PMID: 14634488.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    110. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcohol Clin Exp Res. 2003 Oct; 27(10):1599-605. Vagts AJ, He DY, Yaka R, Ron D. PMID: 14574230.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    111. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron. 2003 Jul 31; 39(3):401-7. Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. PMID: 12895416.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    112. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci. 2003 May 01; 23(9):3623-32. Yaka R, Phamluong K, Ron D. PMID: 12736333.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    113. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biol Chem. 2003 Jun 27; 278(26):23823-9. Thornton C, Yaka R, Dinh S, Ron D. PMID: 12695509.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    114. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003 Mar 14; 278(11):9630-8. Yaka R, He DY, Phamluong K, Ron D. PMID: 12524444.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    115. Glutathione S-transferase pull-down assay. Methods Mol Biol. 2003; 233:345-50. Schechtman D, Mochly-Rosen D, Ron D. PMID: 12840520.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    116. Alcohol addiction. Methods Mol Biol. 2003; 233:555-70. Olive MF, Ron D. PMID: 12840534.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    117. Alcohol Addiction. Protein Kinase C Protocols. 2003 Jan 1; 233:555-570. M. Foster Olive, Dorit Ron. .
      View in: Publisher Site   Mentions:
    118. Glutathione S-Transferase Pull-Down Assay. Protein Kinase C Protocols. 2003 Jan 1; 233:345-350. Deborah Schechtman, Daria Mochly-Rosen, Dorit Ron. .
      View in: Publisher Site   Mentions:
    119. Ethanol induces gene expression via nuclear compartmentalization of receptor for activated C kinase 1. Mol Pharmacol. 2002 Aug; 62(2):272-80. He DY, Vagts AJ, Yaka R, Ron D. PMID: 12130678.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    120. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5710-5. Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. PMID: 11943848.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
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