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Stephen Massa, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentNeurology
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 2469
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    ShEEP request for Real-Time Quantitative PCR machine
    VA IS1BX003569May 1, 2016 - Sep 30, 2016
    Role: Principal Investigator
    Trk Ligands for Treatment of Traumatic Brain Injury
    VA I01BX000267Oct 1, 2009 - Dec 31, 2018
    Role: Principal Investigator
    STRESS GENES IN BRAIN ISCHEMIA
    NIH/NINDS K08NS001662Sep 1, 1993 - Aug 31, 1998
    Role: Principal Investigator
    CHARACTERIZATION OF AN 18K BRAIN LECTIN
    NIH/NINDS F32NS008650Aug 28, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA. Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. Nat Commun. 2017 09 22; 8(1):624. PMID: 28935892.
      View in: PubMed
    2. Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM. A data-driven approach for evaluating multi-modal therapy in traumatic brain injury. Sci Rep. 2017 Feb 16; 7:42474. PMID: 28205533.
      View in: PubMed
    3. Simmons DA, Longo FM, Massa SM. Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease. CNS Neurol Disord Drug Targets. 2017; 16(3):291-302. PMID: 27823570.
      View in: PubMed
    4. Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum Mol Genet. 2016 11 15; 25(22):4920-4938. PMID: 28171570.
      View in: PubMed
    5. Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci. 2016 Sep 28; 36(39):10116-27. PMID: 27683907.
      View in: PubMed
    6. Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 11; 110(Pt A):343-361. PMID: 27334657.
      View in: PubMed
    7. Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15; 79(6):463-73. PMID: 26204799; PMCID: PMC4676961 [Available on 03/15/17].
    8. Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q. Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology. 2014 Dec; 45:81-90. PMID: 25277379; PMCID: PMC4268328.
    9. Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014; 9(8):e102136. PMID: 25153701; PMCID: PMC4143160.
    10. Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice. J Alzheimers Dis. 2014; 42(2):459-83. PMID: 24898660; PMCID: PMC4278429.
    11. Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM. A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. J Neurosci. 2013 Nov 27; 33(48):18712-27. PMID: 24285878; PMCID: PMC3841443.
    12. Shi J, Longo FM, Massa SM. A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury. Stem Cells. 2013 Nov; 31(11):2561-74. PMID: 23940017.
      View in: PubMed
    13. Longo FM, Massa SM. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov. 2013 Jul; 12(7):507-25. PMID: 23977697.
      View in: PubMed
    14. Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J. Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury. Neurorehabil Neural Repair. 2013 Nov-Dec; 27(9):889-99. PMID: 23778701.
      View in: PubMed
    15. Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiol Aging. 2013 Aug; 34(8):2052-63. PMID: 23545424.
      View in: PubMed
    16. Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO. Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J Neurosci. 2013 Jan 09; 33(2):397-410. PMID: 23303920; PMCID: PMC3710149.
    17. Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS. Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke. Stroke. 2012 Jul; 43(7):1918-24. PMID: 22535263; PMCID: PMC3383889.
    18. d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA. Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation. 2012 Feb 15; 9:31. PMID: 22335939; PMCID: PMC3298794.
    19. Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci. 2012 Feb 01; 32(5):1803-10. PMID: 22302819; PMCID: PMC3710112.
    20. Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM. PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease. J Huntingtons Dis. 2012; 1(2):211-9. PMID: 25063332.
      View in: PubMed
    21. Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010 May; 120(5):1774-85. PMID: 20407211; PMCID: PMC2860903.
    22. Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci. 2009 Aug 26; 29(34):10627-37. PMID: 19710315; PMCID: PMC2771439.
    23. Lu Q, Longo FM, Zhou H, Massa SM, Chen YH. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem. 2009; 16(11):1355-65. PMID: 19355891; PMCID: PMC3829470.
    24. Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM. Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PLoS One. 2008; 3(11):e3604. PMID: 18978948; PMCID: PMC2575383.
    25. James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q. Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. Neurotoxicology. 2008 Jul; 29(4):605-12. PMID: 18539332; PMCID: PMC2615238.
    26. Longo FM, Massa SM. Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol Disord Drug Targets. 2008 Feb; 7(1):63-70. PMID: 18289033.
      View in: PubMed
    27. Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Curr Alzheimer Res. 2007 Dec; 4(5):503-6. PMID: 18220511.
      View in: PubMed
    28. Shi J, Miles DK, Orr BA, Massa SM, Kernie SG. Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels. Eur J Neurosci. 2007 Jun; 25(12):3499-512. PMID: 17610570.
      View in: PubMed
    29. Yang T, Massa SM, Longo FM. LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. J Neurobiol. 2006 Nov; 66(13):1420-36. PMID: 17013927.
      View in: PubMed
    30. Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L. Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. Eur J Neurosci. 2006 Sep; 24(6):1575-80. PMID: 17004921.
      View in: PubMed
    31. Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM. Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J Neurosci. 2006 May 17; 26(20):5288-300. PMID: 16707781.
      View in: PubMed
    32. Xie Y, Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, Longo FM. Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function. J Biol Chem. 2006 Jun 16; 281(24):16482-92. PMID: 16613844.
      View in: PubMed
    33. Longo FM, Yang T, Xie Y, Massa SM. Small molecule approaches for promoting neurogenesis. Curr Alzheimer Res. 2006 Feb; 3(1):5-10. PMID: 16472196.
      View in: PubMed
    34. Nguyen T, Hamby A, Massa SM. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11840-5. PMID: 16087879; PMCID: PMC1187967.
    35. Longo FM, Massa SM. Neurotrophin receptor-based strategies for Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):167-9. PMID: 15974914.
      View in: PubMed
    36. Longo FM, Massa SM. Neurotrophin-based strategies for neuroprotection. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S13-7. PMID: 15665408.
      View in: PubMed
    37. Longo FM, Massa SM. Neuroprotective strategies in Alzheimer's disease. NeuroRx. 2004 Jan; 1(1):117-27. PMID: 15717012.
      View in: PubMed
    38. Zhang C, Xie Y, Martignetti JA, Yeo TT, Massa SM, Longo FM. A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA Cell Biol. 2003 May; 22(5):303-15. PMID: 12941158.
      View in: PubMed
    39. Yang T, Bernabeu R, Xie Y, Zhang JS, Massa SM, Rempel HC, Longo FM. Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. J Neurosci. 2003 Apr 15; 23(8):3353-63. PMID: 12716943.
      View in: PubMed
    40. Li Y, Yao XM, Hong-Brown L, Massa SM. Adaptable modification of adenoviral tropism using a bifunctional ligand protein. Virus Res. 2003 Feb; 91(2):223-30. PMID: 12573501.
      View in: PubMed
    41. Massa SM, Xie Y, Longo FM. Alzheimer's therapeutics: neurotrophin domain small molecule mimetics. J Mol Neurosci. 2003; 20(3):323-6. PMID: 14501015.
      View in: PubMed
    42. Massa SM, Xie Y, Longo FM. Alzheimer's therapeutics: neurotrophin small molecule mimetics. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):107-11. PMID: 12212765.
      View in: PubMed