Stephen Massa, MD, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-750-2011 ext. 2469
vCardDownload vCard
    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    p75NTR ligands for ALS therapy
    NIH I21BX004612Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    ShEEP request for Real-Time Quantitative PCR machine
    NIH IS1BX003569May 1, 2016 - Sep 30, 2016
    Role: Principal Investigator
    Trk Ligands for Treatment of Traumatic Brain Injury
    NIH I01BX000267Oct 1, 2009 - Dec 31, 2018
    Role: Principal Investigator
    STRESS GENES IN BRAIN ISCHEMIA
    NIH K08NS001662Sep 1, 1993 - Aug 31, 1998
    Role: Principal Investigator
    CHARACTERIZATION OF AN 18K BRAIN LECTIN
    NIH F32NS008650Aug 28, 1989
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies. Sci Rep. 2020 11 23; 10(1):20322. Yang T, Tran KC, Zeng AY, Massa SM, Longo FM. PMID: 33230162.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice. Acta Neuropathol Commun. 2020 09 05; 8(1):156. Yang T, Liu H, Tran KC, Leng A, Massa SM, Longo FM. PMID: 32891185.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019; 13:533. Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. PMID: 31312116.
      View in: PubMed   Mentions:
    4. Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration. Sci Rep. 2019 03 27; 9(1):5273. Xie Y, Meeker RB, Massa SM, Longo FM. PMID: 30918278.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    5. Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. Nat Commun. 2017 09 22; 8(1):624. Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA. PMID: 28935892.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    6. A data-driven approach for evaluating multi-modal therapy in traumatic brain injury. Sci Rep. 2017 02 16; 7:42474. Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM. PMID: 28205533.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    7. Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease. CNS Neurol Disord Drug Targets. 2017; 16(3):291-302. Simmons DA, Longo FM, Massa SM. PMID: 27823570.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum Mol Genet. 2016 11 15; 25(22):4920-4938. Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. PMID: 28171570.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    9. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci. 2016 09 28; 36(39):10116-27. Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. PMID: 27683907.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    10. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 11; 110(Pt A):343-361. Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM. PMID: 27334657.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15; 79(6):463-73. Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. PMID: 26204799.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    12. Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology. 2014 Dec; 45:81-90. Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q. PMID: 25277379.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    13. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014; 9(8):e102136. Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. PMID: 25153701.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    14. Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice. J Alzheimers Dis. 2014; 42(2):459-83. Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM. PMID: 24898660.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    15. A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. J Neurosci. 2013 Nov 27; 33(48):18712-27. Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM. PMID: 24285878.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    16. A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury. Stem Cells. 2013 Nov; 31(11):2561-74. Shi J, Longo FM, Massa SM. PMID: 23940017.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov. 2013 Jul; 12(7):507-25. Longo FM, Massa SM. PMID: 23977697.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    18. Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury. Neurorehabil Neural Repair. 2013 Nov-Dec; 27(9):889-99. Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J. PMID: 23778701.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiol Aging. 2013 Aug; 34(8):2052-63. Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. PMID: 23545424.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    20. Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J Neurosci. 2013 Jan 09; 33(2):397-410. Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO. PMID: 23303920.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    21. Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke. Stroke. 2012 Jul; 43(7):1918-24. Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS. PMID: 22535263.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    22. Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation. 2012 Feb 15; 9:31. d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA. PMID: 22335939.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    23. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci. 2012 Feb 01; 32(5):1803-10. Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM. PMID: 22302819.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    24. PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease. J Huntingtons Dis. 2012; 1(2):211-9. Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM. PMID: 25063332.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    25. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010 May; 120(5):1774-85. Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. PMID: 20407211.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    26. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci. 2009 Aug 26; 29(34):10627-37. Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. PMID: 19710315.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    27. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem. 2009; 16(11):1355-65. Lu Q, Longo FM, Zhou H, Massa SM, Chen YH. PMID: 19355891.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    28. Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PLoS One. 2008; 3(11):e3604. Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM. PMID: 18978948.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    29. Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. Neurotoxicology. 2008 Jul; 29(4):605-12. James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q. PMID: 18539332.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    30. Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol Disord Drug Targets. 2008 Feb; 7(1):63-70. Longo FM, Massa SM. PMID: 18289033.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    31. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Curr Alzheimer Res. 2007 Dec; 4(5):503-6. Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM. PMID: 18220511.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    32. Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels. Eur J Neurosci. 2007 Jun; 25(12):3499-512. Shi J, Miles DK, Orr BA, Massa SM, Kernie SG. PMID: 17610570.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. J Neurobiol. 2006 Nov; 66(13):1420-36. Yang T, Massa SM, Longo FM. PMID: 17013927.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. Eur J Neurosci. 2006 Sep; 24(6):1575-80. Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L. PMID: 17004921.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    35. Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J Neurosci. 2006 May 17; 26(20):5288-300. Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM. PMID: 16707781.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    36. Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function. J Biol Chem. 2006 Jun 16; 281(24):16482-92. Xie Y, Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, Longo FM. PMID: 16613844.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    37. Small molecule approaches for promoting neurogenesis. Curr Alzheimer Res. 2006 Feb; 3(1):5-10. Longo FM, Yang T, Xie Y, Massa SM. PMID: 16472196.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11840-5. Nguyen T, Hamby A, Massa SM. PMID: 16087879.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    39. Neurotrophin receptor-based strategies for Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):167-9. Longo FM, Massa SM. PMID: 15974914.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    40. Neurotrophin-based strategies for neuroprotection. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S13-7. Longo FM, Massa SM. PMID: 15665408.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. Neuroprotective strategies in Alzheimer's disease. NeuroRx. 2004 Jan; 1(1):117-27. Longo FM, Massa SM. PMID: 15717012.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    42. A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA Cell Biol. 2003 May; 22(5):303-15. Zhang C, Xie Y, Martignetti JA, Yeo TT, Massa SM, Longo FM. PMID: 12941158.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    43. Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. J Neurosci. 2003 Apr 15; 23(8):3353-63. Yang T, Bernabeu R, Xie Y, Zhang JS, Massa SM, Rempel HC, Longo FM. PMID: 12716943.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    44. Adaptable modification of adenoviral tropism using a bifunctional ligand protein. Virus Res. 2003 Feb; 91(2):223-30. Li Y, Yao XM, Hong-Brown L, Massa SM. PMID: 12573501.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    45. Alzheimer's therapeutics: neurotrophin domain small molecule mimetics. J Mol Neurosci. 2003; 20(3):323-6. Massa SM, Xie Y, Longo FM. PMID: 14501015.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Alzheimer's therapeutics: neurotrophin small molecule mimetics. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):107-11. Massa SM, Xie Y, Longo FM. PMID: 12212765.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    Stephen's Networks
    Concepts (301)
    Derived automatically from this person's publications.
    _
    Co-Authors (6)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _