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    Fred Schaufele, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentOb/Gyn, Reproductive Sciences
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-7086
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bailey K, Yazdi T, Masharani U, Tyrrell B, Butch A, Schaufele F. Advantages and Limitations of Androgen Receptor-Based Methods for Detecting Anabolic Androgenic Steroid Abuse as Performance Enhancing Drugs. PLoS One. 2016; 11(3):e0151860. PMID: 26998755.
        View in: PubMed
      2. Schaufele F. Studying Nuclear Receptor Complexes in the Cellular Environment. Methods Mol Biol. 2016; 1443:79-104. PMID: 27246335.
        View in: PubMed
      3. Fujinaga K, Luo Z, Schaufele F, Peterlin BM. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells. J Biol Chem. 2015 Jan 16; 290(3):1829-36. PMID: 25492871; PMCID: PMC4340424 [Available on 01/16/16].
      4. Catalano KJ, Maddux BA, Szary J, Youngren JF, Goldfine ID, Schaufele F. Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain. PLoS One. 2014; 9(9):e108693. PMID: 25259572; PMCID: PMC4178179.
      5. Schaufele F. Maximizing the quantitative accuracy and reproducibility of Förster resonance energy transfer measurement for screening by high throughput widefield microscopy. Methods. 2014 Mar 15; 66(2):188-99. PMID: 23927839; PMCID: PMC3916941.
      6. Krylova I, Kumar RR, Kofoed EM, Schaufele F. A versatile, bar-coded nuclear marker/reporter for live cell fluorescent and multiplexed high content imaging. PLoS One. 2013; 8(5):e63286. PMID: 23691010; PMCID: PMC3653935.
      7. Schaufele F. FRET analysis of androgen receptor structure and biochemistry in living cells. Methods Mol Biol. 2011; 776:147-66. PMID: 21796526.
        View in: PubMed
      8. Kofoed EM, Guerbadot M, Schaufele F. Structure, affinity, and availability of estrogen receptor complexes in the cellular environment. J Biol Chem. 2010 Jan 22; 285(4):2428-37. PMID: 19926790; PMCID: PMC2807300.
      9. Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, Staub RE, Baggett S, Herber CB, Griffin C, Tagliaferri M, Harris HA, Cohen I, Bjeldanes LF, Speed TP, Schaufele F, Leitman DC. Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS One. 2009; 4(7):e6271. PMID: 19609440; PMCID: PMC2707612.
      10. Kofoed EM, Guerbadot M, Schaufele F. Dimerization between aequorea fluorescent proteins does not affect interaction between tagged estrogen receptors in living cells. J Biomed Opt. 2008 May-Jun; 13(3):031207. PMID: 18601531; PMCID: PMC2581880.
      11. Day RN, Schaufele F. Fluorescent protein tools for studying protein dynamics in living cells: a review. J Biomed Opt. 2008 May-Jun; 13(3):031202. PMID: 18601526.
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      12. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49. PMID: 18230651.
        View in: PubMed
      13. Liu X, Wu B, Szary J, Kofoed EM, Schaufele F. Functional sequestration of transcription factor activity by repetitive DNA. J Biol Chem. 2007 Jul 20; 282(29):20868-76. PMID: 17526489; PMCID: PMC3812952.
      14. Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007 Feb; 148(2):538-47. PMID: 17095596.
        View in: PubMed
      15. Padron A, Li L, Kofoed EM, Schaufele F. Ligand-selective interdomain conformations of estrogen receptor-alpha. Mol Endocrinol. 2007 Jan; 21(1):49-61. PMID: 17008385.
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      16. Schaufele F, Carbonell X, Guerbadot M, Borngraeber S, Chapman MS, Ma AA, Miner JN, Diamond MI. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9802-7. PMID: 15994236; PMCID: PMC1168953.
      17. Day RN, Schaufele F. Imaging molecular interactions in living cells. Mol Endocrinol. 2005 Jul; 19(7):1675-86. PMID: 15761028; PMCID: PMC2900770.
      18. Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA. Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol. 2004 Jan; 24(2):675-86. PMID: 14701740; PMCID: PMC343788.
      19. Enwright JF, Kawecki-Crook MA, Voss TC, Schaufele F, Day RN. A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription. Mol Endocrinol. 2003 Feb; 17(2):209-22. PMID: 12554749; PMCID: PMC2900764.
      20. Schaufele F, Wang X, Liu X, Day RN. Conformation of CCAAT/enhancer-binding protein alpha dimers varies with intranuclear location in living cells. J Biol Chem. 2003 Mar 21; 278(12):10578-87. PMID: 12531886.
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      21. Day RN, Voss TC, Enwright JF, Booker CF, Periasamy A, Schaufele F. Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus. Mol Endocrinol. 2003 Mar; 17(3):333-45. PMID: 12554785; PMCID: PMC2910340.
      22. Liu W, Enwright JF, Hyun W, Day RN, Schaufele F. CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle. BMC Cell Biol. 2002 Mar 21; 3:6. PMID: 11914124; PMCID: PMC101385.
      23. Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F. Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol. 2002 Mar; 16(3):487-96. PMID: 11875107.
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      24. Schaufele F, Enwright JF, Wang X, Teoh C, Srihari R, Erickson R, MacDougald OA, Day RN. CCAAT/enhancer binding protein alpha assembles essential cooperating factors in common subnuclear domains. Mol Endocrinol. 2001 Oct; 15(10):1665-76. PMID: 11579200.
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      25. Zhang WH, Srihari R, Day RN, Schaufele F. CCAAT/enhancer-binding protein alpha alters histone H3 acetylation at large subnuclear domains. J Biol Chem. 2001 Nov 2; 276(44):40373-6. PMID: 11568179.
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      26. Day RN, Periasamy A, Schaufele F. Fluorescence resonance energy transfer microscopy of localized protein interactions in the living cell nucleus. Methods. 2001 Sep; 25(1):4-18. PMID: 11558993.
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      27. Lopez GN, Turck CW, Schaufele F, Stallcup MR, Kushner PJ. Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity. J Biol Chem. 2001 Jun 22; 276(25):22177-82. PMID: 11301320.
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      28. Liang F, Schaufele F, Gardner DG. Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription. J Biol Chem. 2001 Jan 12; 276(2):1516-22. PMID: 11022037.
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      29. Schaufele F. Shedding light on molecular timing. Nat Biotechnol. 2001 Jan; 19(1):21-2. PMID: 11135545.
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      30. Schaufele F, Chang CY, Liu W, Baxter JD, Nordeen SK, Wan Y, Day RN, McDonnell DP. Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. Mol Endocrinol. 2000 Dec; 14(12):2024-39. PMID: 11117532.
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      31. Schaufele F. Regulation of estrogen receptor activation of the prolactin enhancer/promoter by antagonistic activation function-2-interacting proteins. Mol Endocrinol. 1999 Jun; 13(6):935-45. PMID: 10379892.
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      32. Liang F, Schaufele F, Gardner DG. Sp1 dependence of natriuretic peptide receptor A gene transcription in rat aortic smooth muscle cells. Endocrinology. 1999 Apr; 140(4):1695-701. PMID: 10098505.
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      33. Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD. Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies. Recent Prog Horm Res. 1998; 53:351-92; discussion 392-4. PMID: 9769715.
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      34. Chuang FM, West BL, Baxter JD, Schaufele F. Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1/nuclear receptor transcriptional synergy. Mol Endocrinol. 1997 Aug; 11(9):1332-41. PMID: 9259323.
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      35. Schaufele F. CCAAT/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells. J Biol Chem. 1996 Aug 30; 271(35):21484-9. PMID: 8702932.
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      36. Chang W, Zhou W, Theill LE, Baxter JD, Schaufele F. An activation function in Pit-1 required selectively for synergistic transcription. J Biol Chem. 1996 Jul 26; 271(30):17733-8. PMID: 8663468.
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      37. Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A. The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner. J Biol Chem. 1996 Jul 19; 271(29):17139-46. PMID: 8663380.
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      38. Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD. The molecular biology of thyroid hormone action. Ann N Y Acad Sci. 1995 Jun 30; 758:366-89. PMID: 7625705.
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      39. Kushner PJ, Baxter JD, Duncan KG, Lopez GN, Schaufele F, Uht RM, Webb P, West BL. Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC. Mol Endocrinol. 1994 Apr; 8(4):405-7. PMID: 8052261.
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      40. Tansey WP, Schaufele F, Heslewood M, Handford C, Reudelhuber TL, Catanzaro DF. Distance-dependent interactions between basal, cyclic AMP, and thyroid hormone response elements in the rat growth hormone promoter. J Biol Chem. 1993 Jul 15; 268(20):14906-11. PMID: 8392063.
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      41. Lopez G, Schaufele F, Webb P, Holloway JM, Baxter JD, Kushner PJ. Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site. Mol Cell Biol. 1993 May; 13(5):3042-9. PMID: 8474460; PMCID: PMC359696.
      42. Schaufele F, West BL, Baxter JD. Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Mol Endocrinol. 1992 Apr; 6(4):656-65. PMID: 1584227.
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      43. Schaufele F, West BL, Reudelhuber TL. Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding. J Biol Chem. 1990 Oct 5; 265(28):17189-96. PMID: 2211620.
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      44. Schaufele F, West BL, Reudelhuber T. Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter. Nucleic Acids Res. 1990 Sep 11; 18(17):5235-43. PMID: 1976240; PMCID: PMC332147.
      45. Schaufele F, Cassill JA, West BL, Reudelhuber T. Resolution by diagonal gel mobility shift assays of multisubunit complexes binding to a functionally important element of the rat growth hormone gene promoter. J Biol Chem. 1990 Aug 25; 265(24):14592-8. PMID: 2387870.
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      46. Vasserot AP, Schaufele FJ, Birnstiel ML. Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4345-9. PMID: 2734288; PMCID: PMC287265.
      47. Gilmartin GM, Schaufele F, Schaffner G, Birnstiel ML. Functional analysis of the sea urchin U7 small nuclear RNA. Mol Cell Biol. 1988 Mar; 8(3):1076-84. PMID: 2835659; PMCID: PMC363250.
      48. Schaufele F, Birnstiel ML. The inability of the Psammechinus miliaris H3 RNA to be processed in the Xenopus oocyte is associated with sequences distinct from those highly conserved amongst sea urchin histone RNAs. Nucleic Acids Res. 1987 Oct 26; 15(20):8305-17. PMID: 2823227; PMCID: PMC306361.
      49. Schaufele F, Gilmartin GM, Bannwarth W, Birnstiel ML. Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA. Nature. 1986 Oct 30-Nov 5; 323(6091):777-81. PMID: 3022153.
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