Robert Fletterick, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #001
San Francisco CA 94158
Phone415-476-2829
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Screening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells
    NIH R03MH094165Jan 15, 2012 - Dec 31, 2013
    Role: Principal Investigator
    Structures of Protein Complexes Regulating Transcription in Enbryonic Stem Cells
    NIH U01GM094614Sep 30, 2010 - Jun 30, 2016
    Role: Principal Investigator
    Nuclear receptor LRH-1 in pancreatic cancer
    NIH R21CA140751Mar 23, 2010 - Feb 29, 2012
    Role: Principal Investigator
    Imaging Nuclear Receptor LRH-1 in Functional Transcriptional Assemblies
    NIH R21DK084504Jun 1, 2009 - May 31, 2011
    Role: Principal Investigator
    Mechanisms of regulation of LRH-1, Nanog and SF-1 by DAX-1
    NIH R01DK078075Dec 10, 2007 - Nov 30, 2012
    Role: Principal Investigator
    A State-of-the-art BIACORE for UCSF Mission Bay
    NIH S10RR023443Mar 23, 2007 - Mar 22, 2008
    Role: Principal Investigator
    Folding of Androgen Receptor-Coregulator Complex
    NIH R21GM077327Sep 25, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Crystal Farm Imaging System
    NIH S10RR022322Apr 15, 2006 - Apr 14, 2007
    Role: Principal Investigator
    REGULATION OF ORPHAN NUCLEAR RECEPTORS LRH-1 AND SF-1
    NIH R21DK067466Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    CONFORMATIONAL CHANGES IN ACTIN
    NIH R01GM067830Aug 1, 2003 - Jul 31, 2007
    Role: Principal Investigator
    Inhibition of Androgen Receptor Activation
    NIH R21CA095324Jul 8, 2002 - Jun 30, 2004
    Role: Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    NEUTRON STUDIES OF REGULATION OF VERTEBRATE MUSCLE
    NIH R01AR045659Sep 1, 1999 - Aug 31, 2005
    Role: Principal Investigator
    REGULATING NEUROTRANSMITTERS THROUGH MONOAMINE OXIDASES
    NIH R01NS037495Jan 5, 1999 - Dec 31, 2003
    Role: Principal Investigator
    LINKING STRUCTURE TO RESPONSE IN THYROID RECEPTOR
    NIH R01DK053417Sep 28, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Structure and Function of Molecular Motors
    NIH P01AR042895Jul 6, 1994 - Jun 30, 2010
    Role: Co-Investigator
    EXCELLENCE IN MOLECULAR BIOLOGY
    NIH P01HL043821Sep 30, 1989 - Nov 30, 1997
    Role: Co-Investigator
    PROTEASE SPECIFICITY AND INHIBITION
    NIH R01DK039304Mar 1, 1988 - Apr 30, 2004
    Role: Principal Investigator
    EVOLUTION OF ALLOSTERIC REGULATION IN PHOSPHORYLASE
    NIH R01DK032822Jan 1, 1984 - Jul 31, 2000
    Role: Principal Investigator
    PRIMARY AND TERTIARY STRUCTURES OF HUMAN PHOSPHORYLASES
    NIH R01AM032822Jan 1, 1984 - Dec 31, 1986
    Role: Principal Investigator
    Macromolecular Diffraction Resource: MacCHESS
    NIH P41RR001646Sep 1, 1983 - Jun 30, 2013
    Role: Co-Investigator
    MOLECULAR BIOLOGY OF CELLULAR GROWTH CONTROL
    NIH P01GM031286Feb 1, 1983 - Jan 31, 1993
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator
    STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHORYLASE A
    NIH R01DK026081Jul 1, 1979 - Jun 30, 1994
    Role: Principal Investigator
    STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHORYLASE A
    NIH R01AM026081Jul 1, 1979 - Jun 30, 1989
    Role: Principal Investigator
    CNS DEGENERATION CAUSED BY NOVEL PATHOGENS
    NIH P50NS014069Nov 30, 2002
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol. 2019 05 16; 26(5):674-685.e6. Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. PMID: 30853418; PMCID: PMC7185887.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    2. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. PMID: 30305617; PMCID: PMC6180039.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    3. Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. ACS Chem Biol. 2017 12 15; 12(12):2934-2939. de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. PMID: 28981251.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. NR5A2 discovering compounds that block tumor growth in PDAC. J Surg Oncol. 2017 Jul; 116(1):89-93. Fletterick R. PMID: 28445593; PMCID: PMC5519325.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    5. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. PMID: 27467220; PMCID: PMC4965143.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    6. Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. J Mol Biol. 2016 Mar 27; 428(6):1130-1141. Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P. PMID: 26829219; PMCID: PMC4826628.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140; PMCID: PMC4749390.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    8. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015 Dec; 192(3):342-348. Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. PMID: 26416531; PMCID: PMC4651778.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    9. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. PLoS One. 2015; 10(7):e0134015. Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson JÅ, Webb P, Cox MB. PMID: 26207810; PMCID: PMC4514735.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4666-71. Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. PMID: 25825768; PMCID: PMC4403148.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    11. Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nat Commun. 2015 Feb 17; 6:6204. Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG. PMID: 25686748; PMCID: PMC5080983.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    12. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2467-72. Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. PMID: 25675535; PMCID: PMC4345603.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    13. Advances in our structural understanding of orphan nuclear receptors. Trends Biochem Sci. 2015 Jan; 40(1):25-35. Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E. PMID: 25499868.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    14. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9. Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. PMID: 25288771; PMCID: PMC4210282.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    15. Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients. Thyroid. 2014 Sep; 24(9):1430-1. Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. PMID: 24906004; PMCID: PMC4361411.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014; 9(6):e99440. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. PMID: 24936658; PMCID: PMC4060991.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    17. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. PMID: 24927529; PMCID: PMC4078864.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    18. Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease. Thyroid. 2013 Dec; 23(12):1638-43. Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. PMID: 23806029; PMCID: PMC3868256.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. PLoS One. 2013; 8(6):e66669. Vinogradova MV, Malanina GG, Waitzman JS, Rice SE, Fletterick RJ. PMID: 23805258; PMCID: PMC3689661.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 05; 288(27):19830-44. Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. PMID: 23667258; PMCID: PMC3707686.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    21. Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761. Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. PMID: 22984442; PMCID: PMC3439487.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):143-8. Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. PMID: 22187462; PMCID: PMC3252924.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    23. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. PMID: 21949357; PMCID: PMC3193228.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    24. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402. Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. PMID: 21878368.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    25. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. PMID: 21730179; PMCID: PMC3141981.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    26. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23. Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. PMID: 21041940; PMCID: PMC4983869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. PMID: 20493816; PMCID: PMC2975025.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    28. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-15267. Pfaff SJ, Fletterick RJ. PMID: 20335180; PMCID: PMC2865338.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. PMID: 20179344; PMCID: PMC2827350.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9. Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. PMID: 19416847; PMCID: PMC2688874.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    31. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7. Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. PMID: 18798561; PMCID: PMC2649980.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. PMID: 19015525; PMCID: PMC2587556.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    33. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. PMID: 18988706; PMCID: PMC2646595.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    34. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. PMID: 18754610; PMCID: PMC2945402.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. PMID: 18790740; PMCID: PMC2583295.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    36. Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J Struct Biol. 2008 Jul; 163(1):76-83. Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. PMID: 18513992.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallogr D Biol Crystallogr. 2007 Nov; 63(Pt 11):1198-200. Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. PMID: 18007036.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 01; 50(22):5269-80. Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. PMID: 17918822; PMCID: PMC2536611.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16074-9. Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. PMID: 17911242; PMCID: PMC1999396.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    40. Perspectives on designs of antiandrogens for prostate cancer. Expert Opin Drug Discov. 2007 Oct; 2(10):1341-55. Estébanez-Perpiñá E, Jouravel N, Fletterick RJ. PMID: 23484530.
      View in: PubMed   Mentions: 3     Fields:    
    41. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol. 2007 Dec; 21(12):2919-28. Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. PMID: 17823305.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    42. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. PMID: 17502099.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    43. Ca ion and the troponin switch. Adv Exp Med Biol. 2007; 592:47-57. Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ. PMID: 17278355.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    44. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794; PMCID: PMC1544199.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    45. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97. Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. PMID: 16962610.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    46. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE. 2006 Jun 27; 2006(341):pl3. Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. PMID: 16804159.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    47. Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J. 2006 Apr 01; 90(7):2436-44. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. PMID: 16415057; PMCID: PMC1403181.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    48. An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol. 2006 Mar 31; 357(3):707-17. Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. PMID: 16469331.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    49. Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJU Int. 2005 Dec; 96 Suppl 2:2-9. Fletterick RJ. PMID: 16359432.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    50. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem. 2005 Dec 30; 280(52):43048-55. Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. PMID: 16263725.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    51. Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem. 2005 Jul 08; 280(27):25665-73. Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. PMID: 15886199.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    52. Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. J Biol Chem. 2005 Jun 10; 280(23):21924-32. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. PMID: 15826946.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5038-43. Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. PMID: 15784741; PMCID: PMC555973.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    54. Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol. 2005 Feb; 93(2-5):127-37. Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. PMID: 15860255.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
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    217. The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science. 1987 Aug 21; 237(4817):905-9. Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. PMID: 3112942.
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    218. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry. 1987 May 05; 26(9):2616-23. Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ. PMID: 3111531.
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    219. The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14. Am J Hum Genet. 1987 Apr; 40(4):351-64. Newgard CB, Fletterick RJ, Anderson LA, Lebo RV. PMID: 2883891; PMCID: PMC1684093.
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    220. Redesigning trypsin via genetic engineering. J Cell Biochem. 1987 Mar; 33(3):199-211. Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. PMID: 3553217.
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    221. The three-dimensional structure of acarbose bound to glycogen phosphorylase. J Biol Chem. 1987 Feb 05; 262(4):1449-55. Goldsmith EJ, Fletterick RJ, Withers SG. PMID: 3805034.
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    222. AIDS virus and scrapie protein genes. Nature. 1987 Feb 12-18; 325(6105):581. Fernando Bazan J, Fletterick RJ, Prusiner SB. PMID: 3100963.
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    223. Predicted secondary structure and membrane topology of the scrapie prion protein. Protein Eng. 1987 Feb-Mar; 1(2):125-35. Bazan JF, Fletterick RJ, McKinley MP, Prusiner SB. PMID: 2907134.
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    224. Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase. Proteins. 1987; 2(3):177-87. Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R. PMID: 3447177.
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    225. Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. Proteins. 1987; 2(3):225-35. Rath VL, Newgard CB, Sprang SR, Goldsmith EJ, Fletterick RJ. PMID: 3447179.
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    226. Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8132-6. Newgard CB, Nakano K, Hwang PK, Fletterick RJ. PMID: 2877458; PMCID: PMC386881.
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    227. Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases. Nature. 1986 Nov 6-12; 324(6092):80-4. Hwang PK, Fletterick RJ. PMID: 3537803.
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    228. Complete cDNA sequence for rabbit muscle glycogen phosphorylase. FEBS Lett. 1986 Aug 18; 204(2):283-7. Nakano K, Hwang PK, Fletterick RJ. PMID: 3015680.
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    229. Turn prediction in proteins using a pattern-matching approach. Biochemistry. 1986 Jan 14; 25(1):266-75. Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. PMID: 3754149.
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    230. Structural relationships in glycogen phosphorylases. Ann N Y Acad Sci. 1986; 478:220-32. Fletterick RJ, Burke JA, Hwang PK, Nakano K, Newgard CB. PMID: 3541750.
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    231. Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs. Eur J Biochem. 1985 Oct 15; 152(2):267-74. Hwang PK, See YP, Vincentini AM, Powers MA, Fletterick RJ, Crerar MM. PMID: 3840433.
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    232. Redesigning trypsin: alteration of substrate specificity. Science. 1985 Apr 19; 228(4697):291-7. Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. PMID: 3838593.
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    233. Measuring X-ray diffraction data from large proteins with X-ray diffractometry. Methods Enzymol. 1985; 114:386-97. Fletterick RJ, Sygusch J. PMID: 4079773.
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    234. Purification and crystallization of bovine liver phosphorylase. Biochim Biophys Acta. 1984 Dec 07; 791(2):252-8. Hwang P, Stern M, Fletterick RJ. PMID: 6509068.
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    235. High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 06; 225(4657):57-9. Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. PMID: 6587566.
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    236. Crystallization of the gene 45 protein from the DNA replication fork of bacteriophage T4. J Biol Chem. 1984 Feb 25; 259(4):2568-9. Thaller C, Alberts B, Goldsmith E, Sprang S, Fletterick R. PMID: 6365913.
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    237. Secondary structure assignment for alpha/beta proteins by a combinatorial approach. Biochemistry. 1983 Oct 11; 22(21):4894-904. Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. PMID: 6639935.
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    238. Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site. Biochemistry. 1983 Sep 13; 22(19):4460-5. Madsen NB, Shechosky S, Fletterick RJ. PMID: 6414512.
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    239. Splice junctions: association with variation in protein structure. Science. 1983 Jun 10; 220(4602):1125-9. Craik CS, Rutter WJ, Fletterick R. PMID: 6344214.
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    240. Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications. Biochemistry. 1982 Oct 12; 21(21):5372-82. Withers SG, Madsen NB, Sprang SR, Fletterick RJ. PMID: 7171564.
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    241. Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose. Biochemistry. 1982 Oct 12; 21(21):5364-71. Sprang SR, Goldsmith EJ, Fletterick RJ, Withers SG, Madsen NB. PMID: 6816272.
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    242. Intron-exon splice junctions map at protein surfaces. Nature. 1982 Sep 09; 299(5879):180-2. Craik CS, Sprang S, Fletterick R, Rutter WJ. PMID: 7110339.
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    243. Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha. Biochemistry. 1982 Apr 27; 21(9):2036-48. Sprang S, Fletterick R, Stern M, Yang D, Madsen N, Sturtevant J. PMID: 7093228.
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    244. Structure of maltoheptaose by difference Fourier methods and a model for glycogen. J Mol Biol. 1982 Apr 05; 156(2):411-27. Goldsmith E, Sprang S, Fletterick R. PMID: 7086906.
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    245. Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes. Can J Biochem. 1981 Jun; 59(6):387-95. Kasvinsky PJ, Fletterick RJ, Madsen NB. PMID: 6794883.
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    246. Subunit interactions and the allosteric response in phosphorylase. Biophys J. 1980 Oct; 32(1):175-92. Sprang S, Fletterick RJ. PMID: 6788104; PMCID: PMC1327277.
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    247. Computer simulation of cellular self-sorting: a topological exchange model. J Theor Biol. 1980 Jun 21; 84(4):673-90. Matela RJ, Fletterick RJ. PMID: 7431947.
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    248. The structures and related functions of phosphorylase a. Annu Rev Biochem. 1980; 49:31-61. Fletterick RJ, Madsen NB. PMID: 6996565.
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    249. Solvent accessibility properties of complex proteins. Nature. 1979 Jul 26; 280(5720):333-5. Sprang S, Yang D, Fletterick RJ. PMID: 460408.
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    250. The structure of glycogen phosphorylase alpha at 2.5 A resolution. J Mol Biol. 1979 Jul 05; 131(3):523-51. Sprang S, Fletterick RJ. PMID: 513128.
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    251. Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms. Can J Biochem. 1979 Jun; 57(6):789-97. Fletterick RJ, Sprang S, Madsen NB. PMID: 476522.
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    252. A systematic approach to isomorphous replacement using a series of simple charged mercurials. Biochem Biophys Res Commun. 1979 Feb 28; 86(4):1044-50. Withers SG, Yang DS, Madsen NB, Fletterick RJ. PMID: 435308.
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    253. A topological exchange model for cell self-sorting. J Theor Biol. 1979 Feb 21; 76(4):403-14. Matela RJ, Fletterick RJ. PMID: 439912.
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    254. Crystallographic analysis of phosphorylase alpha at 2.5 A resolution, a comment on the chemical sequence. Biochemistry. 1978 Dec 26; 17(26):5693-4. Sprang S, Fletterick RJ. PMID: 728427.
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    255. Synergistic regulation of phosphorylase a by glucose and caffeine. J Biol Chem. 1978 Dec 25; 253(24):9102-6. Kasvinsky PJ, Shechosky S, Fletterick RJ. PMID: 721834.
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    256. Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism. J Biol Chem. 1978 Dec 25; 253(24):9097-101. Madsen NB, Fletterick RJ. PMID: 721833.
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    257. The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies. J Biol Chem. 1978 May 10; 253(9):3343-51. Kasvinsky PJ, Madsen NB, Sygusch J, Fletterick RJ. PMID: 641070.
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    258. X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase. J Biol Chem. 1978 Feb 25; 253(4):1290-6. Kasvinsky PJ, Madsen NB, Fletterick RJ, Sygusch J. PMID: 624732.
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    259. Location of pyridoxal phosphate in glycogen phosphorylase a. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):4757-61. Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick RJ. PMID: 270710; PMCID: PMC432034.
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    260. High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site. J Biol Chem. 1977 Jul 10; 252(13):4494-500. Steitz TA, Anderson WF, Fletterick RJ, Anderson CM. PMID: 326777.
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    261. An essential arginine residue in the active-site pocket of glycogen phosporylase. Can J Biochem. 1977 Apr; 55(4):465-73. Li EC, Fletterick RJ, Sygusch J, Madsen NB. PMID: 870152.
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    262. Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A. J Biol Chem. 1976 Oct 10; 251(19):6142-6. Fletterick RJ, Sygusch J, Semple H, Madsen NB. PMID: 184094.
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    263. High resolution x-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits. J Mol Biol. 1976 Jun 14; 104(1):197-22. Steitz TA, Fletterick RJ, Anderson WF, Anderson CM. PMID: 785010.
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    264. Low-resolution structure of the glycogen phosphorylase alpha monomer and comparison with phosphorylase beta. J Mol Biol. 1976 May 05; 103(1):1-13. Fletterick RJ, Sygusch J, Murray N, Madsen NB. PMID: 957422.
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    265. The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):38-42. Fletterick RJ, Bates DJ, Steitz TA. PMID: 164023; PMCID: PMC432235.
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    266. Structure of yeast hexokinase. 3. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding. J Mol Biol. 1974 Jun 25; 86(2):261-9. Anderson WF, Fletterick RJ, Steitz TA. PMID: 4370398.
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    267. Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits. J Mol Biol. 1973 Aug 15; 78(3):551-61. Steitz TA, Fletterick RJ, Hwang KJ. PMID: 4585329.
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    268. The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 01; 75(7):918-22. Fletterick RJ, Tsai CC, Hughes RE. PMID: 5552704.
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    269. The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 01; 75(7):918-22. Fletterick RJ, Tsai C, Hughes RE. PMID: 5135343.
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