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Robert Fletterick, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
Phone415-463-7452
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    Collapse Research 
    Collapse Research Activities and Funding
    Screening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells
    NIH/NIMH R03MH094165Jan 15, 2012 - Dec 31, 2013
    Role: Principal Investigator
    Structures of Protein Complexes Regulating Transcription in Enbryonic Stem Cells
    NIH/NIGMS U01GM094614Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Nuclear receptor LRH-1 in pancreatic cancer
    NIH/NCI R21CA140751Mar 23, 2010 - Feb 29, 2012
    Role: Principal Investigator
    Imaging Nuclear Receptor LRH-1 in Functional Transcriptional Assemblies
    NIH/NIDDK R21DK084504Jun 1, 2009 - May 31, 2011
    Role: Principal Investigator
    Mechanisms of regulation of LRH-1, Nanog and SF-1 by DAX-1
    NIH/NIDDK R01DK078075Dec 10, 2007 - Nov 30, 2012
    Role: Principal Investigator
    A State-of-the-art BIACORE for UCSF Mission Bay
    NIH/NCRR S10RR023443Mar 23, 2007 - Mar 22, 2008
    Role: Principal Investigator
    Folding of Androgen Receptor-Coregulator Complex
    NIH/NIGMS R21GM077327Sep 25, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Crystal Farm Imaging System
    NIH/NCRR S10RR022322Apr 15, 2006 - Apr 14, 2007
    Role: Principal Investigator
    REGULATION OF ORPHAN NUCLEAR RECEPTORS LRH-1 AND SF-1
    NIH/NIDDK R21DK067466Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    CONFORMATIONAL CHANGES IN ACTIN
    NIH/NIGMS R01GM067830Aug 1, 2003 - Jul 31, 2007
    Role: Principal Investigator
    Inhibition of Androgen Receptor Activation
    NIH/NCI R21CA095324Jul 8, 2002 - Jun 30, 2004
    Role: Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH/NIDDK P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    NEUTRON STUDIES OF REGULATION OF VERTEBRATE MUSCLE
    NIH/NIAMS R01AR045659Sep 1, 1999 - Aug 31, 2005
    Role: Principal Investigator
    REGULATING NEUROTRANSMITTERS THROUGH MONOAMINE OXIDASES
    NIH/NINDS R01NS037495Jan 5, 1999 - Dec 31, 2003
    Role: Principal Investigator
    LINKING STRUCTURE TO RESPONSE IN THYROID RECEPTOR
    NIH/NIDDK R01DK053417Sep 28, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Structure and Function of Molecular Motors
    NIH P01AR042895Jul 6, 1994 - Jun 30, 2010
    Role: Co-Investigator
    EXCELLENCE IN MOLECULAR BIOLOGY
    NIH P01HL043821Sep 30, 1989 - Nov 30, 1997
    Role: Co-Investigator
    PROTEASE SPECIFICITY AND INHIBITION
    NIH/NIDDK R01DK039304Mar 1, 1988 - Apr 30, 2004
    Role: Principal Investigator
    EVOLUTION OF ALLOSTERIC REGULATION IN PHOSPHORYLASE
    NIH/NIDDK R01DK032822Jan 1, 1984 - Jul 31, 2000
    Role: Principal Investigator
    PRIMARY AND TERTIARY STRUCTURES OF HUMAN PHOSPHORYLASES
    NIH/NIADDK R01AM032822Jan 1, 1984 - Dec 31, 1986
    Role: Principal Investigator
    Macromolecular Diffraction Resource: MacCHESS
    NIH P41RR001646Sep 1, 1983 - Jun 30, 2013
    Role: Co-Investigator
    MOLECULAR BIOLOGY OF CELLULAR GROWTH CONTROL
    NIH P01GM031286Feb 1, 1983 - Jan 31, 1993
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator
    STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHORYLASE A
    NIH/NIDDK R01DK026081Jul 1, 1979 - Jun 30, 1994
    Role: Principal Investigator
    STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHORYLASE A
    NIH/NIADDK R01AM026081Jul 1, 1979 - Jun 30, 1989
    Role: Principal Investigator
    CNS DEGENERATION CAUSED BY NOVEL PATHOGENS
    NIH/NINDS P50NS014069Dec 1, 1977 - Nov 30, 2002
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. ACS Chem Biol. 2017 12 15; 12(12):2934-2939. PMID: 28981251.
      View in: PubMed
    2. Fletterick R. NR5A2 discovering compounds that block tumor growth in PDAC. J Surg Oncol. 2017 Jul; 116(1):89-93. PMID: 28445593.
      View in: PubMed
    3. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. PMID: 27467220; PMCID: PMC4965143.
    4. Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P. Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. J Mol Biol. 2016 Mar 27; 428(6):1130-1141. PMID: 26829219; PMCID: PMC4826628.
    5. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. PMID: 26653140.
      View in: PubMed
    6. Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015 Dec; 192(3):342-348. PMID: 26416531.
      View in: PubMed
    7. Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson JÅ, Webb P, Cox MB. The FKBP52 Cochaperone Acts in Synergy with ß-Catenin to Potentiate Androgen Receptor Signaling. PLoS One. 2015; 10(7):e0134015. PMID: 26207810; PMCID: PMC4514735.
    8. Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4666-71. PMID: 25825768; PMCID: PMC4403148.
    9. Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG. Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nat Commun. 2015 Feb 17; 6:6204. PMID: 25686748.
      View in: PubMed
    10. Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2467-72. PMID: 25675535; PMCID: PMC4345603.
    11. Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E. Advances in our structural understanding of orphan nuclear receptors. Trends Biochem Sci. 2015 Jan; 40(1):25-35. PMID: 25499868.
      View in: PubMed
    12. Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9. PMID: 25288771; PMCID: PMC4210282.
    13. Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients. Thyroid. 2014 Sep; 24(9):1430-1. PMID: 24906004; PMCID: PMC4361411.
    14. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014; 9(6):e99440. PMID: 24936658; PMCID: PMC4060991.
    15. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8. PMID: 24927529; PMCID: PMC4078864.
    16. Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease. Thyroid. 2013 Dec; 23(12):1638-43. PMID: 23806029; PMCID: PMC3868256.
    17. Vinogradova MV, Malanina GG, Waitzman JS, Rice SE, Fletterick RJ. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. PLoS One. 2013; 8(6):e66669. PMID: 23805258; PMCID: PMC3689661.
    18. Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 05; 288(27):19830-44. PMID: 23667258; PMCID: PMC3707686.
    19. Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761. PMID: 22984442; PMCID: PMC3439487.
    20. Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Structural basis of coactivation of liver receptor homolog-1 by ß-catenin. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):143-8. PMID: 22187462; PMCID: PMC3252924.
    21. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31. PMID: 21949357; PMCID: PMC3193228.
    22. Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402. PMID: 21878368.
      View in: PubMed
    23. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83. PMID: 21730179; PMCID: PMC3141981.
    24. Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23. PMID: 21041940; PMCID: PMC4983869.
    25. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8. PMID: 20493816; PMCID: PMC2975025.
    26. Pfaff SJ, Fletterick RJ. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-67. PMID: 20335180; PMCID: PMC2865338.
    27. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8. PMID: 20179344; PMCID: PMC2827350.
    28. Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9. PMID: 19416847; PMCID: PMC2688874.
    29. Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7. PMID: 18798561; PMCID: PMC2649980.
    30. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5. PMID: 19015525; PMCID: PMC2587556.
    31. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34. PMID: 18988706; PMCID: PMC2646595.
    32. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60. PMID: 18754610; PMCID: PMC2945402.
    33. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9. PMID: 18790740; PMCID: PMC2583295.
    34. Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J Struct Biol. 2008 Jul; 163(1):76-83. PMID: 18513992.
      View in: PubMed
    35. Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallogr D Biol Crystallogr. 2007 Nov; 63(Pt 11):1198-200. PMID: 18007036.
      View in: PubMed
    36. Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 01; 50(22):5269-80. PMID: 17918822; PMCID: PMC2536611.
    37. Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16074-9. PMID: 17911242; PMCID: PMC1999396.
    38. Estébanez-Perpiñá E, Jouravel N, Fletterick RJ. Perspectives on designs of antiandrogens for prostate cancer. Expert Opin Drug Discov. 2007 Oct; 2(10):1341-55. PMID: 23484530.
      View in: PubMed
    39. Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol. 2007 Dec; 21(12):2919-28. PMID: 17823305.
      View in: PubMed
    40. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. PMID: 17502099.
      View in: PubMed
    41. Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ. Ca ion and the troponin switch. Adv Exp Med Biol. 2007; 592:47-57. PMID: 17278355.
      View in: PubMed
    42. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. PMID: 16864794; PMCID: PMC1544199.
    43. Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97. PMID: 16962610.
      View in: PubMed
    44. Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE. 2006 Jun 27; 2006(341):pl3. PMID: 16804159.
      View in: PubMed
    45. Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol. 2006 Mar 31; 357(3):707-17. PMID: 16469331.
      View in: PubMed
    46. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J. 2006 Apr 01; 90(7):2436-44. PMID: 16415057; PMCID: PMC1403181.
    47. Fletterick RJ. Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJU Int. 2005 Dec; 96 Suppl 2:2-9. PMID: 16359432.
      View in: PubMed
    48. Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem. 2005 Dec 30; 280(52):43048-55. PMID: 16263725.
      View in: PubMed
    49. Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem. 2005 Jul 08; 280(27):25665-73. PMID: 15886199.
      View in: PubMed
    50. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. J Biol Chem. 2005 Jun 10; 280(23):21924-32. PMID: 15826946.
      View in: PubMed
    51. Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5038-43. PMID: 15784741; PMCID: PMC555973.
    52. Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol. 2005 Feb; 93(2-5):127-37. PMID: 15860255.
      View in: PubMed
    53. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55. PMID: 15707893.
      View in: PubMed
    54. Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem. 2005 Mar 04; 280(9):8060-8. PMID: 15563469.
      View in: PubMed
    55. Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. Thyroxine-thyroid hormone receptor interactions. J Biol Chem. 2004 Dec 31; 279(53):55801-8. PMID: 15466465.
      View in: PubMed
    56. Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ. Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004 Sep; 2(9):E274. PMID: 15328534; PMCID: PMC509409.
    57. Ruggles SW, Fletterick RJ, Craik CS. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem. 2004 Jul 16; 279(29):30751-9. PMID: 15123647.
      View in: PubMed
    58. Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R. Structure of a kinesin microtubule depolymerization machine. EMBO J. 2004 Apr 07; 23(7):1422-32. PMID: 15029249; PMCID: PMC391071.
    59. Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ. Crystal structure of kinesin regulated by Ca(2+)-calmodulin. J Biol Chem. 2004 May 28; 279(22):23504-9. PMID: 14988396.
      View in: PubMed
    60. Sablin EP, Fletterick RJ. Coordination between motor domains in processive kinesins. J Biol Chem. 2004 Apr 16; 279(16):15707-10. PMID: 14973135.
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    61. Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15358-63. PMID: 14673100; PMCID: PMC307572.
    62. Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ. The extended interactions and Gla domain of blood coagulation factor Xa. Biochemistry. 2003 Jul 08; 42(26):7959-66. PMID: 12834348.
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    63. Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol. 2003 Jul; 10(7):527-34. PMID: 12819769.
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    64. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 2003 Jun; 11(6):1575-85. PMID: 12820970.
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    65. Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ. Two resistance to thyroid hormone mutants with impaired hormone binding. Mol Endocrinol. 2003 Apr; 17(4):643-52. PMID: 12554782.
      View in: PubMed
    66. Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol. 2003 Jan; 17(1):107-16. PMID: 12511610.
      View in: PubMed
    67. Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD. Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):59-73. PMID: 12650702.
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    68. Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R. Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat Struct Biol. 2002 Nov; 9(11):844-8. PMID: 12368902.
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    69. Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol. 2002 Oct; 22(20):7193-203. PMID: 12242296; PMCID: PMC139795.
    70. Dawson JF, Sablin EP, Spudich JA, Fletterick RJ. Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing. J Biol Chem. 2003 Jan 10; 278(2):1229-38. PMID: 12356759.
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