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Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol. 2019 05 16; 26(5):674-685.e6.
Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. PMID: 30853418; PMCID: PMC7185887.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055.
Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. PMID: 30305617; PMCID: PMC6180039.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimals
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Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. ACS Chem Biol. 2017 12 15; 12(12):2934-2939.
de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. PMID: 28981251.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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NR5A2 discovering compounds that block tumor growth in PDAC. J Surg Oncol. 2017 Jul; 116(1):89-93.
Fletterick R. PMID: 28445593; PMCID: PMC5519325.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316.
de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. PMID: 27467220; PMCID: PMC4965143.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. J Mol Biol. 2016 Mar 27; 428(6):1130-1141.
Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P. PMID: 26829219; PMCID: PMC4826628.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4.
Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140; PMCID: PMC4749390.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015 Dec; 192(3):342-348.
Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. PMID: 26416531; PMCID: PMC4651778.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. PLoS One. 2015; 10(7):e0134015.
Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson JÅ, Webb P, Cox MB. PMID: 26207810; PMCID: PMC4514735.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4666-71.
Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. PMID: 25825768; PMCID: PMC4403148.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nat Commun. 2015 Feb 17; 6:6204.
Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG. PMID: 25686748; PMCID: PMC5080983.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2467-72.
Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. PMID: 25675535; PMCID: PMC4345603.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Advances in our structural understanding of orphan nuclear receptors. Trends Biochem Sci. 2015 Jan; 40(1):25-35.
Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E. PMID: 25499868.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
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The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9.
Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. PMID: 25288771; PMCID: PMC4210282.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients. Thyroid. 2014 Sep; 24(9):1430-1.
Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. PMID: 24906004; PMCID: PMC4361411.
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PubMed Mentions: Fields:
Translation:
Humans
-
The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014; 9(6):e99440.
Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. PMID: 24936658; PMCID: PMC4060991.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8.
Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. PMID: 24927529; PMCID: PMC4078864.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease. Thyroid. 2013 Dec; 23(12):1638-43.
Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. PMID: 23806029; PMCID: PMC3868256.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. PLoS One. 2013; 8(6):e66669.
Vinogradova MV, Malanina GG, Waitzman JS, Rice SE, Fletterick RJ. PMID: 23805258; PMCID: PMC3689661.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 05; 288(27):19830-44.
Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. PMID: 23667258; PMCID: PMC3707686.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansCells
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Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761.
Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. PMID: 22984442; PMCID: PMC3439487.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):143-8.
Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. PMID: 22187462; PMCID: PMC3252924.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31.
Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. PMID: 21949357; PMCID: PMC3193228.
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PubMed Mentions:
59 Fields:
Translation:
HumansCells
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A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402.
Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. PMID: 21878368.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83.
De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. PMID: 21730179; PMCID: PMC3141981.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23.
Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. PMID: 21041940; PMCID: PMC4983869.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8.
Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. PMID: 20493816; PMCID: PMC2975025.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-15267.
Pfaff SJ, Fletterick RJ. PMID: 20335180; PMCID: PMC2865338.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8.
Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. PMID: 20179344; PMCID: PMC2827350.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9.
Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. PMID: 19416847; PMCID: PMC2688874.
View in:
PubMed Mentions:
22 Fields:
Translation:
Cells
-
Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7.
Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. PMID: 18798561; PMCID: PMC2649980.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
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The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5.
Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. PMID: 19015525; PMCID: PMC2587556.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34.
Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. PMID: 18988706; PMCID: PMC2646595.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60.
Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. PMID: 18754610; PMCID: PMC2945402.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
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Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9.
Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. PMID: 18790740; PMCID: PMC2583295.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J Struct Biol. 2008 Jul; 163(1):76-83.
Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. PMID: 18513992.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallogr D Biol Crystallogr. 2007 Nov; 63(Pt 11):1198-200.
Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. PMID: 18007036.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 01; 50(22):5269-80.
Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. PMID: 17918822; PMCID: PMC2536611.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16074-9.
Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. PMID: 17911242; PMCID: PMC1999396.
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PubMed Mentions:
109 Fields:
Translation:
AnimalsCells
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Perspectives on designs of antiandrogens for prostate cancer. Expert Opin Drug Discov. 2007 Oct; 2(10):1341-55.
Estébanez-Perpiñá E, Jouravel N, Fletterick RJ. PMID: 23484530.
View in:
PubMed Mentions:
3 Fields:
-
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol. 2007 Dec; 21(12):2919-28.
Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. PMID: 17823305.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43.
Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. PMID: 17502099.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Ca ion and the troponin switch. Adv Exp Med Biol. 2007; 592:47-57.
Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ. PMID: 17278355.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8.
Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794; PMCID: PMC1544199.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97.
Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. PMID: 16962610.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE. 2006 Jun 27; 2006(341):pl3.
Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. PMID: 16804159.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J. 2006 Apr 01; 90(7):2436-44.
Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. PMID: 16415057; PMCID: PMC1403181.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol. 2006 Mar 31; 357(3):707-17.
Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. PMID: 16469331.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJU Int. 2005 Dec; 96 Suppl 2:2-9.
Fletterick RJ. PMID: 16359432.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem. 2005 Dec 30; 280(52):43048-55.
Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. PMID: 16263725.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem. 2005 Jul 08; 280(27):25665-73.
Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. PMID: 15886199.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. J Biol Chem. 2005 Jun 10; 280(23):21924-32.
Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. PMID: 15826946.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5038-43.
Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. PMID: 15784741; PMCID: PMC555973.
View in:
PubMed Mentions:
156 Fields:
Translation:
AnimalsCells
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Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol. 2005 Feb; 93(2-5):127-37.
Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. PMID: 15860255.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55.
Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. PMID: 15707893.
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PubMed Mentions:
185 Fields:
Translation:
HumansAnimalsCells
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The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem. 2005 Mar 04; 280(9):8060-8.
Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. PMID: 15563469.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Thyroxine-thyroid hormone receptor interactions. J Biol Chem. 2004 Dec 31; 279(53):55801-8.
Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. PMID: 15466465.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004 Sep; 2(9):E274.
Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ. PMID: 15328534; PMCID: PMC509409.
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PubMed Mentions:
77 Fields:
Translation:
HumansCells
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Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem. 2004 Jul 16; 279(29):30751-9.
Ruggles SW, Fletterick RJ, Craik CS. PMID: 15123647.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Structure of a kinesin microtubule depolymerization machine. EMBO J. 2004 Apr 07; 23(7):1422-32.
Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R. PMID: 15029249; PMCID: PMC391071.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Crystal structure of kinesin regulated by Ca(2+)-calmodulin. J Biol Chem. 2004 May 28; 279(22):23504-9.
Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ. PMID: 14988396.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Coordination between motor domains in processive kinesins. J Biol Chem. 2004 Apr 16; 279(16):15707-10.
Sablin EP, Fletterick RJ. PMID: 14973135.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15358-63.
Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. PMID: 14673100; PMCID: PMC307572.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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The extended interactions and Gla domain of blood coagulation factor Xa. Biochemistry. 2003 Jul 08; 42(26):7959-66.
Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ. PMID: 12834348.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol. 2003 Jul; 10(7):527-34.
Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. PMID: 12819769.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 2003 Jun; 11(6):1575-85.
Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. PMID: 12820970.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansCells
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Two resistance to thyroid hormone mutants with impaired hormone binding. Mol Endocrinol. 2003 Apr; 17(4):643-52.
Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ. PMID: 12554782.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol. 2003 Jan; 17(1):107-16.
Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. PMID: 12511610.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):59-73.
Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD. PMID: 12650702.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat Struct Biol. 2002 Nov; 9(11):844-8.
Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R. PMID: 12368902.
View in:
PubMed Mentions:
63 Fields:
Translation:
Cells
-
Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol. 2002 Oct; 22(20):7193-203.
Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. PMID: 12242296; PMCID: PMC139795.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing. J Biol Chem. 2003 Jan 10; 278(2):1229-38.
Dawson JF, Sablin EP, Spudich JA, Fletterick RJ. PMID: 12356759.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
How does ATP hydrolysis control actin's associations? Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):10945-7.
Sablin EP, Dawson JF, VanLoock MS, Spudich JA, Egelman EH, Fletterick RJ. PMID: 12167670; PMCID: PMC123189.
View in:
PubMed Mentions:
28 Fields:
Translation:
Cells
-
Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem Biol. 2002 Aug; 9(8):915-24.
Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL. PMID: 12204691.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding. J Biol Chem. 2002 Jul 26; 277(30):27360-6.
Walther M, Anton M, Wiedmann M, Fletterick R, Kuhn H. PMID: 12004065.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem. 2002 Jul 19; 277(29):26623-31.
Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. PMID: 11959867.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology. 2002 Feb; 143(2):517-24.
Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S. PMID: 11796506.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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TR surfaces and conformations required to bind nuclear receptor corepressor. Mol Endocrinol. 2002 Feb; 16(2):271-86.
Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson JL, Fletterick RJ, Baxter JD, West BL. PMID: 11818500.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Nucleotide switches in molecular motors: structural analysis of kinesins and myosins. Curr Opin Struct Biol. 2001 Dec; 11(6):716-24.
Sablin EP, Fletterick RJ. PMID: 11751053.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
-
Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study. Ann Neurol. 2001 Nov; 50(5):574-81.
Martín MA, Rubio JC, Buchbinder J, Fernández-Hojas R, del Hoyo P, Teijeira S, Gámez J, Navarro C, Fernández JM, Cabello A, Campos Y, Cervera C, Culebras JM, Andreu AL, Fletterick R, Arenas J. PMID: 11706962.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28; 40(34):10038-46.
Wang SX, Esmon CT, Fletterick RJ. PMID: 11513582.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Switch-based mechanism of kinesin motors. Nature. 2001 May 24; 411(6836):439-45.
Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N. PMID: 11373668.
View in:
PubMed Mentions:
119 Fields:
Translation:
Cells
-
The role of ecotin dimerization in protease inhibition. J Mol Biol. 2001 May 18; 308(5):975-91.
Eggers CT, Wang SX, Fletterick RJ, Craik CS. PMID: 11352586.
View in:
PubMed Mentions:
15 Fields:
Translation:
Cells
-
Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker. J Biol Chem. 2001 Jul 06; 276(27):25496-502.
Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R. PMID: 11328809.
View in:
PubMed Mentions:
81 Fields:
Translation:
HumansCells
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Hormone selectivity in thyroid hormone receptors. Mol Endocrinol. 2001 Mar; 15(3):398-410.
Wagner RL, Huber BR, Shiau AK, Kelly A, Cunha Lima ST, Scanlan TS, Apriletti JW, Baxter JD, West BL, Fletterick RJ. PMID: 11222741.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor. J Biol Chem. 2001 May 04; 276(18):14987-95.
Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD. PMID: 11145963.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Structural relationships among regulated and unregulated phosphorylases. Annu Rev Biophys Biomol Struct. 2001; 30:191-209.
Buchbinder JL, Rath VL, Fletterick RJ. PMID: 11340058.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Selective modulation of thyroid hormone receptor action. J Steroid Biochem Mol Biol. 2001 Jan-Mar; 76(1-5):31-42.
Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS. PMID: 11384861.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
-
Three-dimensional structural analysis of fibronectin heparin-binding domain mutations. J Cell Biochem Suppl. 2001; Suppl 36:156-61.
Kapila Y, Doan D, Tafolla E, Fletterick R. PMID: 11455580.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity. Nat Struct Biol. 2000 Sep; 7(9):762-5.
Waugh SM, Harris JL, Fletterick R, Craik CS. PMID: 10966646.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15; 8(8):831-40.
Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. PMID: 10997902.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. J Mol Biol. 2000 Jun 16; 299(4):993-1003.
Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. PMID: 10843853.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Searching for kinesin's mechanical amplifier. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):449-57.
Vale RD, Case R, Sablin E, Hart C, Fletterick R. PMID: 10836498; PMCID: PMC1692751.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity. J Biol Chem. 1999 Dec 24; 274(52):37345-50.
Borngräber S, Browner M, Gillmor S, Gerth C, Anton M, Fletterick R, Kühn H. PMID: 10601303.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Visualizing a new binding site of ncd-motor domain on tubulin. J Struct Biol. 1999 Dec 01; 128(1):26-33.
Han Y, Sablin EP, Nogales E, Fletterick RJ, Downing KH. PMID: 10600555.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. J Mol Biol. 1999 Nov 05; 293(4):855-63.
Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE. PMID: 10543972.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3). J Cell Biochem. 1999 Sep 01; 74(3):323-33.
Norman AW, Adams D, Collins ED, Okamura WH, Fletterick RJ. PMID: 10412035.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature. 1999 May 27; 399(6734):371-5.
Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK. PMID: 10360576.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Nuclear-receptor ligands and ligand-binding domains. Annu Rev Biochem. 1999; 68:559-81.
Weatherman RV, Fletterick RJ, Scanlan TS. PMID: 10872460.
View in:
PubMed Mentions:
63 Fields:
-
Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 1998 Dec 01; 37(48):16846-52.
Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. PMID: 9836577.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J Muscle Res Cell Motil. 1998 Nov; 19(8):877-86.
Kull FJ, Vale RD, Fletterick RJ. PMID: 10047987.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
-
Molecular and structural biology of thyroid hormone receptors. Clin Exp Pharmacol Physiol Suppl. 1998 Nov; 25:S2-11.
Apriletti JW, Ribeiro RC, Wagner RL, Feng W, Webb P, Kushner PJ, West BL, Nilsson S, Scanlan TS, Fletterick RJ, Baxter JD. PMID: 9809185.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 1998 Nov 01; 12(21):3343-56.
Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR. PMID: 9808622; PMCID: PMC317236.
View in:
PubMed Mentions:
265 Fields:
Translation:
Cells
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A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi. Biochemistry. 1998 Oct 27; 37(43):15066-75.
Focia PJ, Craig SP, Nieves-Alicea R, Fletterick RJ, Eakin AE. PMID: 9790669.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Direction determination in the minus-end-directed kinesin motor ncd. Nature. 1998 Oct 22; 395(6704):813-6.
Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ. PMID: 9796817.
View in:
PubMed Mentions:
76 Fields:
Translation:
Cells
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A comparison of the crystallographic structures of two catalytic antibodies with esterase activity. J Mol Biol. 1998 Oct 09; 282(5):1033-41.
Buchbinder JL, Stephenson RC, Scanlan TS, Fletterick RJ. PMID: 9753552.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
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A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. EMBO J. 1998 Aug 17; 17(16):4760-70.
Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, Rajanayagam O, Agostini M, Fletterick RJ, Beck-Peccoz P, Reinhardt W, Binder G, Ranke MB, Hermus A, Hesch RD, Lazarus J, Newrick P, Parfitt V, Raggatt P, de Zegher F, Chatterjee VK. PMID: 9707435; PMCID: PMC1170805.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Is the tubulin/FtsZ fold related to the G-protein fold? Trends Cell Biol. 1998 Aug; 8(8):306-7.
Kull FJ, Fletterick RJ. PMID: 9704406.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
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Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. J Mol Biol. 1998 Jun 19; 279(4):945-57.
Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. PMID: 9642073.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science. 1998 Jun 12; 280(5370):1747-9.
Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL. PMID: 9624051.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansCells
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A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation. Mol Endocrinol. 1998 May; 12(5):609-21.
Clifton-Bligh RJ, de Zegher F, Wagner RL, Collingwood TN, Francois I, Van Helvoirt M, Fletterick RJ, Chatterjee VK. PMID: 9605924.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan. Biochemistry. 1998 Apr 21; 37(16):5344-8.
Somoza JR, Skillman AG, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC. PMID: 9548915.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family. Biochemistry. 1998 Apr 14; 37(15):5096-106.
Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ. PMID: 9548740.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
X-ray crystallographic and functional studies of thyroid hormone receptor. J Steroid Biochem Mol Biol. 1998 Apr; 65(1-6):133-41.
Ribeiro RC, Apriletti JW, Wagner RL, Feng W, Kushner PJ, Nilsson S, Scanlan TS, West BL, Fletterick RJ, Baxter JD. PMID: 9699866.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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DAX1 mutations map to putative structural domains in a deduced three-dimensional model. Am J Hum Genet. 1998 Apr; 62(4):855-64.
Zhang YH, Guo W, Wagner RL, Huang BL, McCabe L, Vilain E, Burris TP, Anyane-Yeboa K, Burghes AH, Chitayat D, Chudley AE, Genel M, Gertner JM, Klingensmith GJ, Levine SN, Nakamoto J, New MI, Pagon RA, Pappas JG, Quigley CA, Rosenthal IM, Baxter JD, Fletterick RJ, McCabe ER. PMID: 9529340; PMCID: PMC1377022.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies. Recent Prog Horm Res. 1998; 53:351-92; discussion 392-4.
Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD. PMID: 9769715.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat Struct Biol. 1997 Dec; 4(12):1003-9.
Gillmor SA, Villaseñor A, Fletterick R, Sigal E, Browner MF. PMID: 9406550.
View in:
PubMed Mentions:
110 Fields:
Translation:
AnimalsCells
-
Distinct phosphorylation signals converge at the catalytic center in glycogen phosphorylases. Structure. 1997 Nov 15; 5(11):1511-23.
Lin K, Hwang PK, Fletterick RJ. PMID: 9384566.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. Biochemistry. 1997 Sep 02; 36(35):10666-74.
Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. PMID: 9271497.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Structural determinants of specificity in the cysteine protease cruzain. Protein Sci. 1997 Aug; 6(8):1603-11.
Gillmor SA, Craik CS, Fletterick RJ. PMID: 9260273; PMCID: PMC2143760.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 1997 Jul 25; 90(2):217-24.
Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale RD, Milligan RA. PMID: 9244296.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
-
Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation. Biochemistry. 1997 Jul 01; 36(26):8039-44.
Buchbinder JL, Luong CB, Browner MF, Fletterick RJ. PMID: 9201951.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry. 1997 May 06; 36(18):5381-92.
Perona JJ, Tsu CA, Craik CS, Fletterick RJ. PMID: 9154920.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry. 1997 May 06; 36(18):5393-401.
Tsu CA, Perona JJ, Fletterick RJ, Craik CS. PMID: 9154921.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site. Biochim Biophys Acta. 1997 Apr 25; 1339(1):1-3.
Craig SP, Focia PJ, Fletterick RJ. PMID: 9165092.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):248-53.
Collingwood TN, Rajanayagam O, Adams M, Wagner R, Cavaillès V, Kalkhoven E, Matthews C, Nystrom E, Stenlof K, Lindstedt G, Tisell L, Fletterick RJ, Parker MG, Chatterjee VK. PMID: 8990194; PMCID: PMC19304.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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The design plan of kinesin motors. Annu Rev Cell Dev Biol. 1997; 13:745-77.
Vale RD, Fletterick RJ. PMID: 9442886.
View in:
PubMed Mentions:
148 Fields:
Translation:
HumansAnimalsCells
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A protein phosphorylation switch at the conserved allosteric site in GP. Science. 1996 Sep 13; 273(5281):1539-42.
Lin K, Rath VL, Dai SC, Fletterick RJ, Hwang PK. PMID: 8703213.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding. J Biol Chem. 1996 Sep 13; 271(37):22305-9.
Buchbinder JL, Fletterick RJ. PMID: 8798388.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Structure-based design of parasitic protease inhibitors. Bioorg Med Chem. 1996 Sep; 4(9):1421-7.
Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL. PMID: 8894100.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. Biochemistry. 1996 Jun 04; 35(22):7032-40.
Somoza JR, Chin MS, Focia PJ, Wang CC, Fletterick RJ. PMID: 8679528.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Delocalizing trypsin specificity with metal activation. Biochemistry. 1996 May 14; 35(19):5992-8.
Willett WS, Brinen LS, Fletterick RJ, Craik CS. PMID: 8634240.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
-
X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 1996 May 14; 35(19):5999-6009.
Brinen LS, Willett WS, Craik CS, Fletterick RJ. PMID: 8634241.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
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High-level expression and characterization of a purified 142-residue polypeptide of the prion protein. Biochemistry. 1996 Apr 30; 35(17):5528-37.
Mehlhorn I, Groth D, Stöckel J, Moffat B, Reilly D, Yansura D, Willett WS, Baldwin M, Fletterick R, Cohen FE, Vandlen R, Henner D, Prusiner SB. PMID: 8611544.
View in:
PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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The evolution of an allosteric site in phosphorylase. Structure. 1996 Apr 15; 4(4):463-73.
Rath VL, Lin K, Hwang PK, Fletterick RJ. PMID: 8740368.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996 Apr 11; 380(6574):550-5.
Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD. PMID: 8606779; PMCID: PMC2851642.
View in:
PubMed Mentions:
196 Fields:
Translation:
HumansCells
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Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 1996 Apr 11; 380(6574):555-9.
Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ. PMID: 8606780.
View in:
PubMed Mentions:
115 Fields:
Translation:
AnimalsCells
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A structural role for hormone in the thyroid hormone receptor. Nature. 1995 Dec 14; 378(6558):690-7.
Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ. PMID: 7501015.
View in:
PubMed Mentions:
177 Fields:
Translation:
HumansAnimalsCells
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Mechanism of regulation in yeast glycogen phosphorylase. J Biol Chem. 1995 Nov 10; 270(45):26833-9.
Lin K, Hwang PK, Fletterick RJ. PMID: 7592925.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain. Biochemistry. 1995 Oct 10; 34(40):13259-66.
Shimizu T, Sablin E, Vale RD, Fletterick R, Pechatnikova E, Taylor EW. PMID: 7548090.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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X-ray diffraction of scrapie prion rods and PrP peptides. J Mol Biol. 1995 Sep 29; 252(4):412-22.
Nguyen JT, Inouye H, Baldwin MA, Fletterick RJ, Cohen FE, Prusiner SB, Kirschner DA. PMID: 7563061.
View in:
PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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When one and one are not two. Nat Struct Biol. 1995 Sep; 2(9):721-3.
Fletterick RJ, Bazan JF. PMID: 7552738.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
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Three-dimensional structure of a tubulin-motor-protein complex. Nature. 1995 Jul 20; 376(6537):271-4.
Hoenger A, Sablin EP, Vale RD, Fletterick RJ, Milligan RA. PMID: 7617040.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
The molecular biology of thyroid hormone action. Ann N Y Acad Sci. 1995 Jun 30; 758:366-89.
Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD. PMID: 7625705.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation. J Biol Chem. 1995 Jun 09; 270(23):13748-56.
Crerar MM, Karlsson O, Fletterick RJ, Hwang PK. PMID: 7775430.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Mutations in paired alpha-helices at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity. Biochemistry. 1995 May 16; 34(19):6423-32.
Buchbinder JL, Guinovart JJ, Fletterick RJ. PMID: 7756273.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Crystallization and preliminary diffraction studies of thioesterase II from rat mammary gland. Proteins. 1995 May; 22(1):73-5.
Buchbinder JL, Witkowski A, Smith S, Fletterick RJ. PMID: 7675790.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24; 247(2):251-9.
McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. PMID: 7707373.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
-
Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1694-8.
Guo J, Huang W, Zhou GW, Fletterick RJ, Scanlan TS. PMID: 7878042; PMCID: PMC42586.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Engineered metal regulation of trypsin specificity. Biochemistry. 1995 Feb 21; 34(7):2172-80.
Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS. PMID: 7857928.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry. 1995 Feb 07; 34(5):1489-99.
Perona JJ, Hedstrom L, Rutter WJ, Fletterick RJ. PMID: 7849008.
View in:
PubMed Mentions:
27 Fields:
Translation:
Cells
-
Ecotin: lessons on survival in a protease-filled world. Protein Sci. 1995 Feb; 4(2):141-8.
McGrath ME, Gillmor SA, Fletterick RJ. PMID: 7757004; PMCID: PMC2143063.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Crystallization and preliminary structural studies of the ncd motor domain. Proteins. 1995 Jan; 21(1):68-9.
Sablin EP, Fletterick RJ. PMID: 7716170.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Parallel evolution in two homologues of phosphorylase. Nat Struct Biol. 1994 Oct; 1(10):681-90.
Rath VL, Fletterick RJ. PMID: 7634071.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Crystal structure of a catalytic antibody with a serine protease active site. Science. 1994 Aug 19; 265(5175):1059-64.
Zhou GW, Guo J, Huang W, Fletterick RJ, Scanlan TS. PMID: 8066444.
View in:
PubMed Mentions:
24 Fields:
Translation:
Cells
-
A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA. Protein Sci. 1994 Aug; 3(8):1276-85.
Guenot J, Fletterick RJ, Kollman PA. PMID: 7987223; PMCID: PMC2142927.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Proposed three-dimensional structure for the cellular prion protein. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7139-43.
Huang Z, Gabriel JM, Baldwin MA, Fletterick RJ, Prusiner SB, Cohen FE. PMID: 7913747; PMCID: PMC44354.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Identification of the molecular trigger for allosteric activation in glycogen phosphorylase. Nat Struct Biol. 1994 May; 1(5):327-33.
Browner MF, Hackos D, Fletterick R. PMID: 7664039.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Structural clues to prion replication. Science. 1994 Apr 22; 264(5158):530-1.
Cohen FE, Pan KM, Huang Z, Baldwin M, Fletterick RJ, Prusiner SB. PMID: 7909169.
View in:
PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
-
Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex. EMBO J. 1994 Apr 01; 13(7):1502-7.
McGrath ME, Erpel T, Bystroff C, Fletterick RJ. PMID: 8156987; PMCID: PMC394978.
View in:
PubMed Mentions:
14 Fields:
-
Deconvoluting serpins. Nat Struct Biol. 1994 Apr; 1(4):201-3.
Fletterick RJ, McGrath ME. PMID: 7656041.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition. Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29; 343(1306):435-41.
Baldwin MA, Pan KM, Nguyen J, Huang Z, Groth D, Serban A, Gasset M, Mehlhorn I, Fletterick RJ, Cohen FE, et al. PMID: 7913763.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine. J Mol Biol. 1994 Mar 25; 237(2):236-9.
McGrath ME, Wagner RL, Apriletti JW, West BL, Ramalingam V, Baxter JD, Fletterick RJ. PMID: 8126736.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
-
Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 1994 Mar 22; 33(11):3252-9.
Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. PMID: 8136360.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):10962-6.
Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE, et al. PMID: 7902575; PMCID: PMC47901.
View in:
PubMed Mentions:
657 Fields:
Translation:
AnimalsCells
-
PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):429-39.
Baker D, Bystroff C, Fletterick RJ, Agard DA. PMID: 15299502.
View in:
PubMed Mentions:
8 Fields:
-
PRISM: application to the solution of two protein structures. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):440-8.
Bystroff C, Baker D, Fletterick RJ, Agard DA. PMID: 15299503.
View in:
PubMed Mentions:
2 Fields:
-
Locating the catalytic water molecule in serine proteases. Science. 1993 Jul 30; 261(5121):620-2.
Perona JJ, Craik CS, Fletterick RJ. PMID: 8342029.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Relocating a negative charge in the binding pocket of trypsin. J Mol Biol. 1993 Apr 05; 230(3):934-49.
Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ. PMID: 8478942.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI. J Mol Biol. 1993 Apr 05; 230(3):919-33.
Perona JJ, Tsu CA, Craik CS, Fletterick RJ. PMID: 7683059.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J Biol Chem. 1993 Mar 25; 268(9):6115-8.
Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS. PMID: 8454586.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Structure of an engineered, metal-actuated switch in trypsin. Biochemistry. 1993 Mar 02; 32(8):1914-9.
McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ. PMID: 8448149.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):1-5.
Gasset M, Baldwin MA, Fletterick RJ, Prusiner SB. PMID: 8419912; PMCID: PMC45587.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
-
Purification of glycogen phosphorylase isozymes by metal-affinity chromatography. J Chromatogr. 1992 Dec 11; 584(1):77-84.
Luong CB, Browner MF, Fletterick RJ, Haymore BL. PMID: 1487518.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Tracking conformational states in allosteric transitions of phosphorylase. Biochemistry. 1992 Nov 24; 31(46):11297-304.
Browner MF, Fauman EB, Fletterick RJ. PMID: 1445867.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Cooperative binding is not required for activation of muscle phosphorylase. Biochemistry. 1992 Nov 24; 31(46):11291-6.
Browner MF, Hwang PK, Fletterick RJ. PMID: 1445866.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution. J Mol Biol. 1992 Nov 20; 228(2):580-95.
Goddette DW, Paech C, Yang SS, Mielenz JR, Bystroff C, Wilke ME, Fletterick RJ. PMID: 1453465.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10940-4.
Gasset M, Baldwin MA, Lloyd DH, Gabriel JM, Holtzman DM, Cohen F, Fletterick R, Prusiner SB. PMID: 1438300; PMCID: PMC50458.
View in:
PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
-
Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae. J Mol Biol. 1992 Jun 20; 225(4):1027-34.
Rath VL, Hwang PK, Fletterick RJ. PMID: 1613787.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry. 1992 Mar 31; 31(12):3059-64.
McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ. PMID: 1554694.
View in:
PubMed Mentions:
19 Fields:
Translation:
Cells
-
Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin. J Bacteriol. 1992 Mar; 174(5):1704.
Erpel T, Hwang P, Craik CS, Fletterick RJ, McGrath ME. PMID: 1537814; PMCID: PMC206573.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
Engineered metalloregulation in enzymes. Trends Biochem Sci. 1992 Mar; 17(3):100-4.
Higaki JN, Fletterick RJ, Craik CS. PMID: 1329276.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Phosphorylase: a biological transducer. Trends Biochem Sci. 1992 Feb; 17(2):66-71.
Browner MF, Fletterick RJ. PMID: 1566331.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate. Science. 1991 Nov 29; 254(5036):1367-71.
Sprang SR, Withers SG, Goldsmith EJ, Fletterick RJ, Madsen NB. PMID: 1962195.
View in:
PubMed Mentions:
36 Fields:
Translation:
Cells
-
Expression of the protease inhibitor ecotin and its co-crystallization with trypsin. J Mol Biol. 1991 Nov 20; 222(2):139-42.
McGrath ME, Erpel T, Browner MF, Fletterick RJ. PMID: 1960717.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
-
An engineered liver glycogen phosphorylase with AMP allosteric activation. J Biol Chem. 1991 Aug 25; 266(24):16113-9.
Coats WS, Browner MF, Fletterick RJ, Newgard CB. PMID: 1874749.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
-
Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases. J Mol Biol. 1991 Jun 05; 219(3):511-23.
Wilke ME, Higaki JN, Craik CS, Fletterick RJ. PMID: 1904942.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis. J Mol Biol. 1991 Jun 05; 219(3):525-32.
Wilke ME, Higaki JN, Craik CS, Fletterick RJ. PMID: 2051486.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli. J Biol Chem. 1991 Apr 05; 266(10):6620-5.
McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS. PMID: 2007606.
View in:
PubMed Mentions:
20 Fields:
Translation:
Cells
-
Temperature-sensitive production of rabbit muscle glycogen phosphorylase in Escherichia coli. Protein Eng. 1991 Feb; 4(3):351-7.
Browner MF, Rasor P, Tugendreich S, Fletterick RJ. PMID: 1857717.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Hydrogen bonds involving sulfur atoms in proteins. Proteins. 1991; 9(2):99-107.
Gregoret LM, Rader SD, Fletterick RJ, Cohen FE. PMID: 1755867.
View in:
PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
-
Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes. Biochem Biophys Res Commun. 1990 Dec 14; 173(2):507-13.
Sloane DL, Browner MF, Dauter Z, Wilson K, Fletterick RJ, Sigal E. PMID: 2260964.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Arginine 127 stabilizes the transition state in carboxypeptidase. J Biol Chem. 1990 Nov 25; 265(33):20692-8.
Phillips MA, Fletterick R, Rutter WJ. PMID: 2243116.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8898-902.
Chambers TJ, Weir RC, Grakoui A, McCourt DW, Bazan JF, Fletterick RJ, Rice CM. PMID: 2147282; PMCID: PMC55067.
View in:
PubMed Mentions:
131 Fields:
Translation:
Cells
-
Rare McArdle disease locus polymorphic site on 11q13 contains CpG sequence. Hum Genet. 1990 Nov; 86(1):17-24.
Lebo RV, Anderson LA, DiMauro S, Lynch E, Hwang P, Fletterick R. PMID: 1701414.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Regulation of serine protease activity by an engineered metal switch. Biochemistry. 1990 Sep 18; 29(37):8582-6.
Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS. PMID: 2125468.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Electrical potentials in trypsin isozymes. Biochemistry. 1989 Dec 26; 28(26):9918-26.
Soman K, Yang AS, Honig B, Fletterick R. PMID: 2695163.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9642-6.
Bazan JF, Fletterick RJ, Pilkis SJ. PMID: 2557623; PMCID: PMC298557.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
-
Crystal structures of two engineered thiol trypsins. Biochemistry. 1989 Nov 28; 28(24):9264-70.
McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ. PMID: 2611228.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones. FASEB J. 1989 Nov; 3(13):2532-6.
Zhang WM, Browner MF, Fletterick RJ, DePaoli-Roach AA, Roach PJ. PMID: 2509275.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase. Virology. 1989 Sep; 172(1):302-10.
Dougherty WG, Parks TD, Cary SM, Bazan JF, Fletterick RJ. PMID: 2475971.
View in:
PubMed Mentions:
34 Fields:
Translation:
Cells
-
Domain separation in the activation of glycogen phosphorylase a. Science. 1989 Aug 04; 245(4917):528-32.
Goldsmith EJ, Sprang SR, Hamlin R, Xuong NH, Fletterick RJ. PMID: 2756432.
View in:
PubMed Mentions:
13 Fields:
Translation:
Cells
-
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses. Virology. 1989 Aug; 171(2):637-9.
Bazan JF, Fletterick RJ. PMID: 2548336.
View in:
PubMed Mentions:
109 Fields:
Translation:
Cells
-
Comparative analysis of viral cysteine protease structural models. FEBS Lett. 1989 May 22; 249(1):5-7.
Bazan JF, Fletterick RJ. PMID: 2721688.
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PubMed Mentions:
5 Fields:
Translation:
Cells
-
Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiae. Mol Cell Biol. 1989 Apr; 9(4):1659-66.
Hwang PK, Tugendreich S, Fletterick RJ. PMID: 2657401; PMCID: PMC362584.
View in:
PubMed Mentions:
35 Fields:
Translation:
Animals
-
Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution. Proc Natl Acad Sci U S A. 1989 Mar; 86(5):1443-7.
Browner MF, Nakano K, Bang AG, Fletterick RJ. PMID: 2493642; PMCID: PMC286712.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
-
Rapid preparation of proteins for crystallization trials. Biotechniques. 1989 Mar; 7(3):246-7.
McGrath ME, Fletterick RJ, Craik CS. PMID: 2631770.
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PubMed Mentions: Fields:
Translation:
Cells
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The family of glycogen phosphorylases: structure and function. Crit Rev Biochem Mol Biol. 1989; 24(1):69-99.
Newgard CB, Hwang PK, Fletterick RJ. PMID: 2667896.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
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McArdle's disease: biochemical and molecular genetic studies. Ann Neurol. 1988 Dec; 24(6):774-81.
Servidei S, Shanske S, Zeviani M, Lebo R, Fletterick R, DiMauro S. PMID: 3207360.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Structural changes in glycogen phosphorylase induced by phosphorylation. Nature. 1988 Nov 17; 336(6196):215-21.
Sprang SR, Acharya KR, Goldsmith EJ, Stuart DI, Varvill K, Fletterick RJ, Madsen NB, Johnson LN. PMID: 3194008.
View in:
PubMed Mentions:
62 Fields:
Translation:
Cells
-
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7872-6.
Bazan JF, Fletterick RJ. PMID: 3186696; PMCID: PMC282299.
View in:
PubMed Mentions:
138 Fields:
Translation:
AnimalsCells
-
Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. J Biol Chem. 1988 Mar 15; 263(8):3850-7.
Newgard CB, Littman DR, van Genderen C, Smith M, Fletterick RJ. PMID: 3346228.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansCells
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Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants. Crit Rev Biotechnol. 1988; 8(3):225-36.
Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS. PMID: 3063392.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
The burden of proof in linking AIDS to scrapie. Nature. 1987 Dec 10-16; 330(6148):525-6.
Braun MJ, Gonda MA, George DG, Bazan JF, Fletterick RJ, Prusiner SB. PMID: 2891035.
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PubMed Mentions:
1 Fields:
Translation:
Cells
-
Primary sequence and structural analysis of sterol carrier protein 2 from rat liver: homology with immunoglobulins. J Biol Chem. 1987 Sep 25; 262(27):13219-27.
Pastuszyn A, Noland BJ, Bazan JF, Fletterick RJ, Scallen TJ. PMID: 3115977.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Structure of the nucleotide activation switch in glycogen phosphorylase a. Science. 1987 Aug 28; 237(4818):1012-9.
Sprang S, Goldsmith E, Fletterick R. PMID: 3616621.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science. 1987 Aug 21; 237(4817):905-9.
Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. PMID: 3112942.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
-
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry. 1987 May 05; 26(9):2616-23.
Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ. PMID: 3111531.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14. Am J Hum Genet. 1987 Apr; 40(4):351-64.
Newgard CB, Fletterick RJ, Anderson LA, Lebo RV. PMID: 2883891; PMCID: PMC1684093.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Redesigning trypsin via genetic engineering. J Cell Biochem. 1987 Mar; 33(3):199-211.
Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. PMID: 3553217.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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The three-dimensional structure of acarbose bound to glycogen phosphorylase. J Biol Chem. 1987 Feb 05; 262(4):1449-55.
Goldsmith EJ, Fletterick RJ, Withers SG. PMID: 3805034.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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AIDS virus and scrapie protein genes. Nature. 1987 Feb 12-18; 325(6105):581.
Fernando Bazan J, Fletterick RJ, Prusiner SB. PMID: 3100963.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Predicted secondary structure and membrane topology of the scrapie prion protein. Protein Eng. 1987 Feb-Mar; 1(2):125-35.
Bazan JF, Fletterick RJ, McKinley MP, Prusiner SB. PMID: 2907134.
View in:
PubMed Mentions:
14 Fields:
Translation:
Cells
-
Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase. Proteins. 1987; 2(3):177-87.
Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R. PMID: 3447177.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. Proteins. 1987; 2(3):225-35.
Rath VL, Newgard CB, Sprang SR, Goldsmith EJ, Fletterick RJ. PMID: 3447179.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases. Nature. 1986 Nov 6-12; 324(6092):80-4.
Hwang PK, Fletterick RJ. PMID: 3537803.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8132-6.
Newgard CB, Nakano K, Hwang PK, Fletterick RJ. PMID: 2877458; PMCID: PMC386881.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Complete cDNA sequence for rabbit muscle glycogen phosphorylase. FEBS Lett. 1986 Aug 18; 204(2):283-7.
Nakano K, Hwang PK, Fletterick RJ. PMID: 3015680.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Turn prediction in proteins using a pattern-matching approach. Biochemistry. 1986 Jan 14; 25(1):266-75.
Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. PMID: 3754149.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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Structural relationships in glycogen phosphorylases. Ann N Y Acad Sci. 1986; 478:220-32.
Fletterick RJ, Burke JA, Hwang PK, Nakano K, Newgard CB. PMID: 3541750.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs. Eur J Biochem. 1985 Oct 15; 152(2):267-74.
Hwang PK, See YP, Vincentini AM, Powers MA, Fletterick RJ, Crerar MM. PMID: 3840433.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Redesigning trypsin: alteration of substrate specificity. Science. 1985 Apr 19; 228(4697):291-7.
Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. PMID: 3838593.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Measuring X-ray diffraction data from large proteins with X-ray diffractometry. Methods Enzymol. 1985; 114:386-97.
Fletterick RJ, Sygusch J. PMID: 4079773.
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PubMed Mentions: Fields:
Translation:
Cells
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Purification and crystallization of bovine liver phosphorylase. Biochim Biophys Acta. 1984 Dec 07; 791(2):252-8.
Hwang P, Stern M, Fletterick RJ. PMID: 6509068.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 06; 225(4657):57-9.
Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. PMID: 6587566.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Crystallization of the gene 45 protein from the DNA replication fork of bacteriophage T4. J Biol Chem. 1984 Feb 25; 259(4):2568-9.
Thaller C, Alberts B, Goldsmith E, Sprang S, Fletterick R. PMID: 6365913.
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PubMed Mentions: Fields:
Translation:
Cells
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Secondary structure assignment for alpha/beta proteins by a combinatorial approach. Biochemistry. 1983 Oct 11; 22(21):4894-904.
Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. PMID: 6639935.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site. Biochemistry. 1983 Sep 13; 22(19):4460-5.
Madsen NB, Shechosky S, Fletterick RJ. PMID: 6414512.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Splice junctions: association with variation in protein structure. Science. 1983 Jun 10; 220(4602):1125-9.
Craik CS, Rutter WJ, Fletterick R. PMID: 6344214.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications. Biochemistry. 1982 Oct 12; 21(21):5372-82.
Withers SG, Madsen NB, Sprang SR, Fletterick RJ. PMID: 7171564.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose. Biochemistry. 1982 Oct 12; 21(21):5364-71.
Sprang SR, Goldsmith EJ, Fletterick RJ, Withers SG, Madsen NB. PMID: 6816272.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Intron-exon splice junctions map at protein surfaces. Nature. 1982 Sep 09; 299(5879):180-2.
Craik CS, Sprang S, Fletterick R, Rutter WJ. PMID: 7110339.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha. Biochemistry. 1982 Apr 27; 21(9):2036-48.
Sprang S, Fletterick R, Stern M, Yang D, Madsen N, Sturtevant J. PMID: 7093228.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Structure of maltoheptaose by difference Fourier methods and a model for glycogen. J Mol Biol. 1982 Apr 05; 156(2):411-27.
Goldsmith E, Sprang S, Fletterick R. PMID: 7086906.
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PubMed Mentions:
29 Fields:
Translation:
Cells
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Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes. Can J Biochem. 1981 Jun; 59(6):387-95.
Kasvinsky PJ, Fletterick RJ, Madsen NB. PMID: 6794883.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Subunit interactions and the allosteric response in phosphorylase. Biophys J. 1980 Oct; 32(1):175-92.
Sprang S, Fletterick RJ. PMID: 6788104; PMCID: PMC1327277.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Computer simulation of cellular self-sorting: a topological exchange model. J Theor Biol. 1980 Jun 21; 84(4):673-90.
Matela RJ, Fletterick RJ. PMID: 7431947.
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PubMed Mentions: Fields:
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The structures and related functions of phosphorylase a. Annu Rev Biochem. 1980; 49:31-61.
Fletterick RJ, Madsen NB. PMID: 6996565.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Solvent accessibility properties of complex proteins. Nature. 1979 Jul 26; 280(5720):333-5.
Sprang S, Yang D, Fletterick RJ. PMID: 460408.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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The structure of glycogen phosphorylase alpha at 2.5 A resolution. J Mol Biol. 1979 Jul 05; 131(3):523-51.
Sprang S, Fletterick RJ. PMID: 513128.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms. Can J Biochem. 1979 Jun; 57(6):789-97.
Fletterick RJ, Sprang S, Madsen NB. PMID: 476522.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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A systematic approach to isomorphous replacement using a series of simple charged mercurials. Biochem Biophys Res Commun. 1979 Feb 28; 86(4):1044-50.
Withers SG, Yang DS, Madsen NB, Fletterick RJ. PMID: 435308.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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A topological exchange model for cell self-sorting. J Theor Biol. 1979 Feb 21; 76(4):403-14.
Matela RJ, Fletterick RJ. PMID: 439912.
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PubMed Mentions: Fields:
Translation:
Cells
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Crystallographic analysis of phosphorylase alpha at 2.5 A resolution, a comment on the chemical sequence. Biochemistry. 1978 Dec 26; 17(26):5693-4.
Sprang S, Fletterick RJ. PMID: 728427.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Synergistic regulation of phosphorylase a by glucose and caffeine. J Biol Chem. 1978 Dec 25; 253(24):9102-6.
Kasvinsky PJ, Shechosky S, Fletterick RJ. PMID: 721834.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism. J Biol Chem. 1978 Dec 25; 253(24):9097-101.
Madsen NB, Fletterick RJ. PMID: 721833.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies. J Biol Chem. 1978 May 10; 253(9):3343-51.
Kasvinsky PJ, Madsen NB, Sygusch J, Fletterick RJ. PMID: 641070.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase. J Biol Chem. 1978 Feb 25; 253(4):1290-6.
Kasvinsky PJ, Madsen NB, Fletterick RJ, Sygusch J. PMID: 624732.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Location of pyridoxal phosphate in glycogen phosphorylase a. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):4757-61.
Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick RJ. PMID: 270710; PMCID: PMC432034.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site. J Biol Chem. 1977 Jul 10; 252(13):4494-500.
Steitz TA, Anderson WF, Fletterick RJ, Anderson CM. PMID: 326777.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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An essential arginine residue in the active-site pocket of glycogen phosporylase. Can J Biochem. 1977 Apr; 55(4):465-73.
Li EC, Fletterick RJ, Sygusch J, Madsen NB. PMID: 870152.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A. J Biol Chem. 1976 Oct 10; 251(19):6142-6.
Fletterick RJ, Sygusch J, Semple H, Madsen NB. PMID: 184094.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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High resolution x-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits. J Mol Biol. 1976 Jun 14; 104(1):197-22.
Steitz TA, Fletterick RJ, Anderson WF, Anderson CM. PMID: 785010.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Low-resolution structure of the glycogen phosphorylase alpha monomer and comparison with phosphorylase beta. J Mol Biol. 1976 May 05; 103(1):1-13.
Fletterick RJ, Sygusch J, Murray N, Madsen NB. PMID: 957422.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):38-42.
Fletterick RJ, Bates DJ, Steitz TA. PMID: 164023; PMCID: PMC432235.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Structure of yeast hexokinase. 3. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding. J Mol Biol. 1974 Jun 25; 86(2):261-9.
Anderson WF, Fletterick RJ, Steitz TA. PMID: 4370398.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits. J Mol Biol. 1973 Aug 15; 78(3):551-61.
Steitz TA, Fletterick RJ, Hwang KJ. PMID: 4585329.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 01; 75(7):918-22.
Fletterick RJ, Tsai CC, Hughes RE. PMID: 5552704.
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PubMed Mentions: Fields:
Translation:
Cells
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The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 01; 75(7):918-22.
Fletterick RJ, Tsai C, Hughes RE. PMID: 5135343.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells