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Umesh Masharani, MBBS

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-353-2350
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency Internal Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Chromium and Insulin Resistance
    NIH/NCCIH R21AT002616Aug 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    BIOGENESIS, TOPOLOGY AND FUNCTION OF GRP 94
    NIH/NIGMS F32GM015460Aug 1, 1993
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Sep 29, 2006
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shumway M, Fisher L, Hessler D, Bowyer V, Polonsky WH, Masharani U. Economic costs of implementing group interventions to reduce diabetes distress in adults with type 1 diabetes mellitus in the T1-REDEEM trial. J Diabetes Complications. 2019 Nov; 33(11):107416. PMID: 31473079.
      View in: PubMed
    2. Hessler D, Fisher L, Polonsky W, Strycker L, Parra J, Bowyer V, Dedhia M, Masharani U. There is value in treating elevated levels of diabetes distress: the clinical impact of targeted interventions in adults with Type 1 diabetes. Diabet Med. 2020 Jan; 37(1):71-74. PMID: 31314907.
      View in: PubMed
    3. Fisher L, Hessler D, Polonsky W, Strycker L, Bowyer V, Masharani U. Toward effective interventions to reduce diabetes distress among adults with type 1 diabetes: Enhancing?Emotion regulation and cognitive skills. Patient Educ Couns. 2019 08; 102(8):1499-1505. PMID: 30952482.
      View in: PubMed
    4. Kim S, Dillon WP, Hope TA, El-Sayed IH, van Zante A, Wu K, Masharani U. Ectopic Thyroid-Stimulating Hormone-Secreting Pituitary Adenoma of the Nasopharynx Diagnosed by Gallium 68 DOTATATE Positron Emission Tomography/Computed Tomography. World Neurosurg. 2019 05; 125:400-404. PMID: 30797906.
      View in: PubMed
    5. Wentworth KL, Masharani U, Hsiao EC. Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva. Br J Clin Pharmacol. 2019 06; 85(6):1180-1187. PMID: 30501012.
      View in: PubMed
    6. Masharani U, Alba D. Methadone-Associated Hypoglycemia in Chronic Renal Failure Masquerading as an Insulinoma. Pain Med. 2018 09 01; 19(9):1876-1878. PMID: 29145621.
      View in: PubMed
    7. Fisher L, Hessler D, Polonsky WH, Masharani U, Guzman S, Bowyer V, Strycker L, Ahmann A, Basina M, Blumer I, Chloe C, Kim S, Peters AL, Shumway M, Weihs K, Wu P. T1-REDEEM: A Randomized Controlled Trial to Reduce Diabetes Distress Among Adults With Type 1 Diabetes. Diabetes Care. 2018 09; 41(9):1862-1869. PMID: 29976567.
      View in: PubMed
    8. Fisher L, Hessler D, Polonsky W, Strycker L, Guzman S, Bowyer V, Blumer I, Masharani U. Emotion regulation contributes to the development of diabetes distress among adults with type 1 diabetes. Patient Educ Couns. 2018 Jan; 101(1):124-131. PMID: 28739179.
      View in: PubMed
    9. Hessler DM, Fisher L, Polonsky WH, Masharani U, Strycker LA, Peters AL, Blumer I, Bowyer V. Diabetes distress is linked with worsening diabetes management over time in adults with Type 1 diabetes. Diabet Med. 2017 09; 34(9):1228-1234. PMID: 28498610.
      View in: PubMed
    10. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy. Ann Nucl Med. 2017 May; 31(4):295-303. PMID: 28260185.
      View in: PubMed
    11. Mulvey CK, Van Loon K, Bergsland EK, Masharani U, Nakakura EK. Complicated Case Presentation: Management of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1. Pancreas. 2017 03; 46(3):416-426. PMID: 28187108.
      View in: PubMed
    12. Fisher L, Hessler D, Polonsky W, Strycker L, Masharani U, Peters A. Diabetes distress in adults with type 1 diabetes: Prevalence, incidence and change over time. J Diabetes Complications. 2016 08; 30(6):1123-8. PMID: 27118163.
      View in: PubMed
    13. Bailey K, Yazdi T, Masharani U, Tyrrell B, Butch A, Schaufele F. Advantages and Limitations of Androgen Receptor-Based Methods for Detecting Anabolic Androgenic Steroid Abuse as Performance Enhancing Drugs. PLoS One. 2016; 11(3):e0151860. PMID: 26998755.
      View in: PubMed
    14. Fisher L, Hessler DM, Polonsky WH, Masharani U, Peters AL, Blumer I, Strycker LA. Prevalence of depression in Type 1 diabetes and the problem of over-diagnosis. Diabet Med. 2016 11; 33(11):1590-1597. PMID: 26433004.
      View in: PubMed
    15. Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM. A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes. Am J Transplant. 2016 Feb; 16(2):518-26. PMID: 26595767.
      View in: PubMed
    16. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. PMID: 26253396.
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    17. Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015 Aug; 69(8):944-8. PMID: 25828624.
      View in: PubMed
    18. Fisher L, Polonsky WH, Hessler DM, Masharani U, Blumer I, Peters AL, Strycker LA, Bowyer V. Understanding the sources of diabetes distress in adults with type 1 diabetes. J Diabetes Complications. 2015 May-Jun; 29(4):572-7. PMID: 25765489.
      View in: PubMed
    19. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J. 2015 Feb; 29(2):589-96. PMID: 25342129.
      View in: PubMed
    20. Chandran S, Masharani U, Webber AB, Wojciechowski DM. Prediabetic living kidney donors have preserved kidney function at 10 years after donation. Transplantation. 2014 Apr 15; 97(7):748-54. PMID: 24342975.
      View in: PubMed
    21. Fisher L, Hessler D, Masharani U, Strycker L. Impact of baseline patient characteristics on interventions to reduce diabetes distress: the role of personal conscientiousness and diabetes self-efficacy. Diabet Med. 2014 Jun; 31(6):739-46. PMID: 24494593.
      View in: PubMed
    22. Hessler D, Fisher L, Glasgow RE, Strycker LA, Dickinson LM, Arean PA, Masharani U. Reductions in regimen distress are associated with improved management and glycemic control over time. Diabetes Care. 2014; 37(3):617-24. PMID: 24170750.
      View in: PubMed
    23. Draznin B, Gilden J, Golden SH, Inzucchi SE, Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, Kosiborod M, Lien LF, Magee MF, Masharani U, Maynard G, McDonnell ME, Moghissi ES, Rasouli N, Rubin DJ, Rushakoff RJ, Sadhu AR, Schwartz S, Seley JJ, Umpierrez GE, Vigersky RA, Low CC, Wexler DJ. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care. 2013 Jul; 36(7):1807-14. PMID: 23801791.
      View in: PubMed
    24. Fisher L, Hessler D, Glasgow RE, Arean PA, Masharani U, Naranjo D, Strycker LA. REDEEM: a pragmatic trial to reduce diabetes distress. Diabetes Care. 2013 Sep; 36(9):2551-8. PMID: 23735726.
      View in: PubMed
    25. Masharani U, Gjerde C, McCoy S, Maddux BA, Hessler D, Goldfine ID, Youngren JF. Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity. BMC Endocr Disord. 2012 Nov 30; 12:31. PMID: 23194380.
      View in: PubMed
    26. Hessler DM, Fisher L, Naranjo D, Masharani U. Young adult African American patients with type 2 diabetes: a high risk patient sub-group with few supports for good diabetes management. J Health Psychol. 2012 May; 17(4):535-44. PMID: 21963680.
      View in: PubMed
    27. Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012 Jan; 35(1):117-24. PMID: 22190287.
      View in: PubMed
    28. Masharani UB, Maddux BA, Li X, Sakkas GK, Mulligan K, Schambelan M, Goldfine ID, Youngren JF. Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle. PLoS One. 2011 May 11; 6(5):e19878. PMID: 21589939.
      View in: PubMed
    29. Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation. 2010 Dec 27; 90(12):1595-601. PMID: 20978464.
      View in: PubMed
    30. Hessler DM, Fisher L, Mullan JT, Glasgow RE, Masharani U. Patient age: a neglected factor when considering disease management in adults with type 2 diabetes. Patient Educ Couns. 2011 Nov; 85(2):154-9. PMID: 21112720.
      View in: PubMed
    31. Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM. High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2010 Nov; 95(11):5045-55. PMID: 20719835.
      View in: PubMed
    32. Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. Am J Transplant. 2010 Aug; 10(8):1870-80. PMID: 20659093.
      View in: PubMed
    33. Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID. Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome. J Diabetes Sci Technol. 2010 Mar 01; 4(2):359-64. PMID: 20307398.
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    34. Masharani UB, Becker J. Teplizumab therapy for type 1 diabetes. Expert Opin Biol Ther. 2010 Mar; 10(3):459-65. PMID: 20095914.
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    35. Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG. Clinical islet transplantation at the University of California, San Francisco. Clin Transpl. 2010; 235-43. PMID: 21698834.
      View in: PubMed
    36. Fisher L, Mullan JT, Arean P, Glasgow RE, Hessler D, Masharani U. Diabetes distress but not clinical depression or depressive symptoms is associated with glycemic control in both cross-sectional and longitudinal analyses. Diabetes Care. 2010 Jan; 33(1):23-8. PMID: 19837786.
      View in: PubMed
    37. Masharani U, Goldfine ID, Youngren JF. Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects. Metabolism. 2009 Nov; 58(11):1602-8. PMID: 19604524.
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    38. Skaff MM, Mullan JT, Almeida DM, Hoffman L, Masharani U, Mohr D, Fisher L. Daily negative mood affects fasting glucose in type 2 diabetes. Health Psychol. 2009 May; 28(3):265-72. PMID: 19450031.
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    39. Masharani U, Rushakoff RJ. Update on systemic management of diabetes. Int Ophthalmol Clin. 2009; 49(2):13-33. PMID: 19349784.
      View in: PubMed
    40. Fisher L, Skaff MM, Mullan JT, Arean P, Glasgow R, Masharani U. A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with Type 2 diabetes. Diabet Med. 2008 Sep; 25(9):1096-101. PMID: 19183314.
      View in: PubMed
    41. Sweet MP, Izumisato Y, Way LW, Clark OH, Masharani U, Duh QY. Laparoscopic enucleation of insulinomas. Arch Surg. 2007 Dec; 142(12):1202-4; discussion 1205. PMID: 18086988.
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    42. Li X, Youngren JF, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID. Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T. Magn Reson Imaging. 2008 Feb; 26(2):188-97. PMID: 17683890.
      View in: PubMed
    43. Fisher L, Skaff MM, Mullan JT, Arean P, Mohr D, Masharani U, Glasgow R, Laurencin G. Clinical depression versus distress among patients with type 2 diabetes: not just a question of semantics. Diabetes Care. 2007 Mar; 30(3):542-8. PMID: 17327318.
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    44. Archea C, Yen IH, Chen H, Eisner MD, Katz PP, Masharani U, Yelin EH, Earnest G, Blanc PD. Negative life events and quality of life in adults with asthma. Thorax. 2007 Feb; 62(2):139-46. PMID: 16928721.
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    45. Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes. 2005 Jun; 54(6):1763-9. PMID: 15919798.
      View in: PubMed
    46. Masharani U, Shiboski S, Eisner MD, Katz PP, Janson SL, Granger DA, Blanc PD. Impact of exogenous glucocorticoid use on salivary cortisol measurements among adults with asthma and rhinitis. Psychoneuroendocrinology. 2005 Sep; 30(8):744-52. PMID: 15919580.
      View in: PubMed
    47. Blanc PD, Eisner MD, Katz PP, Yen IH, Archea C, Earnest G, Janson S, Masharani UB, Quinlan PJ, Hammond SK, Thorne PS, Balmes JR, Trupin L, Yelin EH. Impact of the home indoor environment on adult asthma and rhinitis. J Occup Environ Med. 2005 Apr; 47(4):362-72. PMID: 15824627.
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    48. Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC. Insulin secretion in type 1 diabetes. Diabetes. 2004 Feb; 53(2):426-33. PMID: 14747294.
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    49. Campos E, Kotite L, Blanche P, Mitsugi Y, Frost PH, Masharani U, Krauss RM, Havel RJ. Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma. J Lipid Res. 2002 Mar; 43(3):365-74. PMID: 11893772.
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    50. Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S. Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients. Diabetologia. 2000 May; 43(5):598-608. PMID: 10855535.
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    51. Murphy EJ, Davern TJ, Shakil AO, Shick L, Masharani U, Chow H, Freise C, Lee WM, Bass NM. Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group. Dig Dis Sci. 2000 Mar; 45(3):549-53. PMID: 10749332.
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    52. Masharani U, Schambelan M. The endocrine complications of acquired immunodeficiency syndrome. Adv Intern Med. 1993; 38:323-36. PMID: 8438644.
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    53. Ordovas JM, Civeira F, Genest J, Craig S, Robbins AH, Meade T, Pocovi M, Frossard PM, Masharani U, Wilson PW. Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis. 1991 Mar; 87(1):75-86. PMID: 1678604.
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    54. Masharani U, Wolf D. BglII restriction fragment length polymorphisms at the human p53 gene locus. Hum Genet. 1990 Dec; 86(2):244. PMID: 1979960.
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    55. Genest JJ, Ordovas JM, McNamara JR, Robbins AM, Meade T, Cohn SD, Salem DN, Wilson PW, Masharani U, Frossard PM. DNA polymorphisms of the apolipoprotein B gene in patients with premature coronary artery disease. Atherosclerosis. 1990 May; 82(1-2):7-17. PMID: 1972879.
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    56. Masharani U. HinfI RFLP at the human renin (REN) gene locus. Nucleic Acids Res. 1989 Jan 11; 17(1):467. PMID: 2563155.
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    57. Tinklenberg KJ, Masharani U, Coleman RT, Taylor J, Cawthorn R, Frossard P. DraI and ScaI RFLPs at human tyrosine hydroxylase (TH) gene locus. Nucleic Acids Res. 1988 Nov 25; 16(22):10948. PMID: 2905044.
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    58. Masharani U, Nakashima PF, Lim DW, Frossard PM. NsiI and ScaI restriction fragment length polymorphisms at the atrial natriuretic peptides (ANP) gene locus. Hum Genet. 1988 Nov; 80(3):307. PMID: 2903848.
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    59. Masharani U, Frossard PM. MspI and HindIII restriction fragment length polymorphisms at the human Na,K-ATPase beta-subunit (ATP1B) gene locus. Hum Genet. 1988 Nov; 80(3):308. PMID: 2461341.
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    60. Masharani U, Coleman RT, Johnson LK, Seilhamer JJ. EcoRI and NsiI RFLPs at a human PLA2 gene on chromosome 1. Nucleic Acids Res. 1988 Sep 26; 16(18):9073. PMID: 2902574.
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    61. Masharani U, Wolf D, Frossard PM. BanII and ScaI RFLPs at the human p53 gene locus. Nucleic Acids Res. 1988 Aug 11; 16(15):7757. PMID: 2901071.
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    62. Masharani U, Baxter JD, Frossard PM. Two EcoT14I RFLPs at the human renin (REN) gene locus. Nucleic Acids Res. 1988 Jul 11; 16(13):6253. PMID: 2899876.
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    63. Masharani U, Frossard PM. MboI RFLP at the human renin (ren) gene locus. Nucleic Acids Res. 1988 Mar 25; 16(5):2357. PMID: 2895911.
      View in: PubMed
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