Steinunn Baekkeskov, PhD

Title(s)Professor Emeritus, Diabetes Center
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-6267
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    GENERATION OF A NON-HUMAN PRIMATE MODEL TYPE
    NIH R21DK055977Sep 30, 1999 - Aug 31, 2002
    Role: Principal Investigator
    IMMUNOPATHOLOGY OF BETA CELL AUTOANTIGENS
    NIH R01DK047043Apr 1, 1994 - Mar 31, 2003
    Role: Principal Investigator
    MOLECULAR CHARACTERIZATION OF B-CELL MEMBRANE ANTIGENS
    NIH R55DK041567Sep 30, 1991 - Sep 29, 1993
    Role: Principal Investigator
    CELL AND MOLECULAR BIOLOGY OF THE PANCREATIC ISLET CELLS
    NIH P01DK041822Aug 1, 1989 - Jul 31, 2001
    Role: Co-Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. Nat Metab. 2019 11; 1(11):1110-1126. Menegaz D, Hagan DW, Almaça J, Cianciaruso C, Rodriguez-Diaz R, Molina J, Dolan RM, Becker MW, Schwalie PC, Nano R, Lebreton F, Kang C, Sah R, Gaisano HY, Berggren PO, Baekkeskov S, Caicedo A, Phelps EA. PMID: 32432213.
      View in: PubMed   Mentions: 10  Translation:HumansCells
    2. Bioengineering strategies for inducing tolerance in autoimmune diabetes. Adv Drug Deliv Rev. 2017 05 15; 114:256-265. Baekkeskov S, Hubbell JA, Phelps EA. PMID: 28625830.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 05 09; 7:46801. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. PMID: 28485397.
      View in: PubMed   Mentions:    Fields:    
    4. Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 04 12; 7:45961. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. PMID: 28401888.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. Diabetes. 2017 02; 66(2):460-473. Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S. PMID: 27872147.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    6. Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity. Diabetes. 2016 09; 65(9):2686-99. Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S. PMID: 27284108.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons. PLoS One. 2015; 10(2):e0117130. Kanaani J, Cianciaruso C, Phelps EA, Pasquier M, Brioudes E, Billestrup N, Baekkeskov S, Kanaani J, Cianciaruso C, Phelps EA, Pasquier M, Brioudes E, Billestrup N, Baekkeskov S. PMID: 25647668; PMCID: PMC4315522.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters. J Cell Biol. 2010 Sep 06; 190(5):911-25. Kanaani J, Kolibachuk J, Martinez H, Baekkeskov S, Kanaani J, Kolibachuk J, Martinez H, Baekkeskov S. PMID: 20805323; PMCID: PMC2935578.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    9. Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun. 2009 Aug; 33(1):50-7. Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC, Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC. PMID: 19289270; PMCID: PMC2705176.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Palmitoylation cycles and regulation of protein function (Review). Mol Membr Biol. 2009 Jan; 26(1):42-54. Baekkeskov S, Kanaani J, Baekkeskov S, Kanaani J. PMID: 19169934.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    11. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S, Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. PMID: 18230651.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    12. Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Neurochem. 2005 Dec; 95(5):1373-86. Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G, Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G. PMID: 16313516.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    13. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. J Cell Sci. 2004 Apr 15; 117(Pt 10):2001-13. Kanaani J, Diacovo MJ, El-Husseini Ael-D, Bredt DS, Baekkeskov S, Kanaani J, Diacovo MJ, El-Husseini Ael-D, Bredt DS, Baekkeskov S. PMID: 15039456.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65. J Cell Biol. 2002 Sep 30; 158(7):1229-38. Kanaani J, el-Husseini Ael-D, Aguilera-Moreno A, Diacovo JM, Bredt DS, Baekkeskov S, Kanaani J, el-Husseini Ael-D, Aguilera-Moreno A, Diacovo JM, Bredt DS, Baekkeskov S. PMID: 12356867; PMCID: PMC2173248.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. J Immunol. 2002 Jul 15; 169(2):665-72. Jaume JC, Parry SL, Madec AM, Sønderstrup G, Baekkeskov S, Jaume JC, Parry SL, Madec AM, Sønderstrup G, Baekkeskov S. PMID: 12097368.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    16. Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety. Eur J Immunol. 2002 01; 32(1):113-21. Wolfe T, Bot A, Hughes A, Möhrle U, Rodrigo E, Jaume JC, Baekkeskov S, von Herrath M, Wolfe T, Bot A, Hughes A, Möhrle U, Rodrigo E, Jaume JC, Baekkeskov S, von Herrath M. PMID: 11754351.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol. 1992 Aug; 6(8):1332-42. Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S, Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S. PMID: 1406710.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    18. Studies of the isolation and viability of human islets of Langerhans. Transplantation. 1988 May; 45(5):957-63. Warnock GL, Ellis D, Rajotte RV, Dawidson I, Baekkeskov S, Egebjerg J, Warnock GL, Ellis D, Rajotte RV, Dawidson I, Baekkeskov S, Egebjerg J. PMID: 2835843.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    19. [Spontaneous diabetes and diabetes induced by streptozotocin in the rat and mouse]. Journ Annu Diabetol Hotel Dieu. 1988; 15-31. Lernmark A, Markholst H, Laursen H, Contreas G, Altieri M, Baekkeskov S, Herold R, Kastern W, Madsen OD, Lernmark A, Markholst H, Laursen H, Contreas G, Altieri M, Baekkeskov S, Herold R, Kastern W, Madsen OD. PMID: 2971832.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    20. Islet-specific immune mechanisms. Diabetes Metab Rev. 1987 Oct; 3(4):959-80. Lernmark A, Li S, Baekkeskov S, Christie M, Michelsen B, Ursing J, Olsson ML, Sundkvist G, Lernmark A, Li S, Baekkeskov S, Christie M, Michelsen B, Ursing J, Olsson ML, Sundkvist G. PMID: 3315527.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Immunological aspects of type 1 and 2 diabetes mellitus. Adv Exp Med Biol. 1985; 189:107-27. Lernmark A, Baekkeskov S, Gerling I, Kastern W, Knutson C, Michelsen B, Lernmark A, Baekkeskov S, Gerling I, Kastern W, Knutson C, Michelsen B. PMID: 4036712.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Glucose stimulates the biosynthesis of a human pancreatic islet cell protein detected by an antiserum against the human erythrocyte glucose transporter. FEBS Lett. 1983 Jul 04; 157(2):331-5. Baekkeskov S, Lernmark A, Baekkeskov S, Lernmark A. PMID: 6190679.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Islet cell antibodies-theoretical and practical implications. Diabetologia. 1981 Nov; 21(5):431-5. Lernmark A, Baekkeskov S, Lernmark A, Baekkeskov S. PMID: 7028555.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    24. Expression of major histocompatibility antigens on pancreatic islet cells. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6456-60. Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A, Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. PMID: 7031653; PMCID: PMC349058.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Islet transplantation in mice differing in the I and S subregions of the H-2 complex. Transplantation. 1981 Jun; 31(6):476-9. Steffes MW, Nielsen O, Dyrberg T, Baekkeskov S, Scott J, Lernmark A, Steffes MW, Nielsen O, Dyrberg T, Baekkeskov S, Scott J, Lernmark A. PMID: 6789509.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Sub-cellular fractionation of Trypanosoma brucei. Isolation and characterization of plasma membranes. Parasitology. 1980 Jun; 80(3):507-24. Rovis L, Baekkeskov S, Rovis L, Baekkeskov S. PMID: 6248830.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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