Steinunn Baekkeskov, PhD

Title(s)Professor Emeritus, Diabetes Center
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-6267
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    GENERATION OF A NON-HUMAN PRIMATE MODEL TYPE
    NIH R21DK055977Sep 30, 1999 - Aug 31, 2002
    Role: Principal Investigator
    IMMUNOPATHOLOGY OF BETA CELL AUTOANTIGENS
    NIH R01DK047043Apr 1, 1994 - Mar 31, 2003
    Role: Principal Investigator
    MOLECULAR CHARACTERIZATION OF B-CELL MEMBRANE ANTIGENS
    NIH R55DK041567Sep 30, 1991 - Sep 29, 1993
    Role: Principal Investigator
    CELL AND MOLECULAR BIOLOGY OF THE PANCREATIC ISLET CELLS
    NIH P01DK041822Aug 1, 1989 - Jul 31, 2001
    Role: Co-Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. Nat Metab. 2019 11; 1(11):1110-1126. Menegaz D, Hagan DW, Almaça J, Cianciaruso C, Rodriguez-Diaz R, Molina J, Dolan RM, Becker MW, Schwalie PC, Nano R, Lebreton F, Kang C, Sah R, Gaisano HY, Berggren PO, Baekkeskov S, Caicedo A, Phelps EA. PMID: 32432213; PMCID: PMC7236889.
      View in: PubMed   Mentions: 10  Translation:HumansCells
    2. Bioengineering strategies for inducing tolerance in autoimmune diabetes. Adv Drug Deliv Rev. 2017 05 15; 114:256-265. Baekkeskov S, Hubbell JA, Phelps EA. PMID: 28625830.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 05 09; 7:46801. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. PMID: 28485397; PMCID: PMC5422918.
      View in: PubMed   Mentions:    Fields:    
    4. Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 04 12; 7:45961. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. PMID: 28401888; PMCID: PMC5388888.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. Diabetes. 2017 02; 66(2):460-473. Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S. PMID: 27872147.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    6. Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity. Diabetes. 2016 09; 65(9):2686-99. Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S. PMID: 27284108; PMCID: PMC5001175.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons. PLoS One. 2015; 10(2):e0117130. Kanaani J, Cianciaruso C, Phelps EA, Pasquier M, Brioudes E, Billestrup N, Baekkeskov S. PMID: 25647668; PMCID: PMC4315522.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters. J Cell Biol. 2010 Sep 06; 190(5):911-25. Kanaani J, Kolibachuk J, Martinez H, Baekkeskov S. PMID: 20805323; PMCID: PMC2935578.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    9. Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun. 2009 Aug; 33(1):50-7. Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC. PMID: 19289270; PMCID: PMC2705176.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Palmitoylation cycles and regulation of protein function (Review). Mol Membr Biol. 2009 Jan; 26(1):42-54. Baekkeskov S, Kanaani J. PMID: 19169934.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    11. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. PMID: 18230651.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    12. Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Neurochem. 2005 Dec; 95(5):1373-86. Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G. PMID: 16313516.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    13. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. J Cell Sci. 2004 Apr 15; 117(Pt 10):2001-13. Kanaani J, Diacovo MJ, El-Husseini Ael-D, Bredt DS, Baekkeskov S. PMID: 15039456.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65. J Cell Biol. 2002 Sep 30; 158(7):1229-38. Kanaani J, el-Husseini Ael-D, Aguilera-Moreno A, Diacovo JM, Bredt DS, Baekkeskov S. PMID: 12356867; PMCID: PMC2173248.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase. Autoimmunity. 2002 Aug; 35(5):343-55. Hayakawa N, Premawardhana LD, Powell M, Masuda M, Arnold C, Sanders J, Evans M, Chen S, Jaume JC, Baekkeskov S, Smith BR, Furmaniak J. PMID: 12515289.
      View in: PubMed   Mentions:
    16. Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. J Immunol. 2002 Jul 15; 169(2):665-72. Jaume JC, Parry SL, Madec AM, Sønderstrup G, Baekkeskov S. PMID: 12097368.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    17. Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety. Eur J Immunol. 2002 01; 32(1):113-21. Wolfe T, Bot A, Hughes A, Möhrle U, Rodrigo E, Jaume JC, Baekkeskov S, von Herrath M. PMID: 11754351.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Does GAD have a unique role in triggering IDDM? J Autoimmun. 2000 Nov; 15(3):279-86. Baekkeskov S, Kanaani J, Jaume JC, Kash S. PMID: 11040068.
      View in: PubMed   Mentions:
    19. Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion. Am J Physiol Endocrinol Metab. 2000 Sep; 279(3):E684-94. Shi Y, Kanaani J, Menard-Rose V, Ma YH, Chang PY, Hanahan D, Tobin A, Grodsky G, Baekkeskov S. PMID: 10950838.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants. Transplantation. 2000 May 15; 69(9):1813-7. Kang SM, Braat D, Schneider DB, O'Rourke RW, Lin Z, Ascher NL, Dichek DA, Baekkeskov S, Stock PG. PMID: 10830216.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients. Diabetologia. 2000 May; 43(5):598-608. Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S. PMID: 10855535.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival. Transplantation. 2000 Apr 15; 69(7):1440-6. O'Rourke RW, Kang SM, Lower JA, Feng S, Ascher NL, Baekkeskov S, Stock PG. PMID: 10798768.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    23. The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65. J Biol Chem. 1999 Dec 24; 274(52):37200-9. Kanaani J, Lissin D, Kash SF, Baekkeskov S. PMID: 10601283.
      View in: PubMed   Mentions:
    24. The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12911-6. Tian N, Petersen C, Kash S, Baekkeskov S, Copenhagen D, Nicoll R. PMID: 10536022; PMCID: PMC23160.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    25. Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice. Horm Metab Res. 1999 May; 31(5):340-4. Kash SF, Condie BG, Baekkeskov S. PMID: 10422732.
      View in: PubMed   Mentions:
    26. High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase. J Mol Biol. 1999 Apr 16; 287(5):983-99. Schwartz HL, Chandonia JM, Kash SF, Kanaani J, Tunnell E, Domingo A, Cohen FE, Banga JP, Madec AM, Richter W, Baekkeskov S. PMID: 10222205.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    27. Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1698-703. Kash SF, Tecott LH, Hodge C, Baekkeskov S. PMID: 9990087; PMCID: PMC15565.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    28. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. Diabetes. 1998 Dec; 47(12):1848-56. Bridgett M, Cetkovic-Cvrlje M, O'Rourke R, Shi Y, Narayanswami S, Lambert J, Ramiya V, Baekkeskov S, Leiter EH. PMID: 9836515.
      View in: PubMed   Mentions:
    29. Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998 Nov 20; 282(5393):1504-8. Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. PMID: 9822384; PMCID: PMC2851625.
      View in: PubMed   Mentions: 326     Fields:    Translation:AnimalsCells
    30. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14060-5. Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov S. PMID: 9391152; PMCID: PMC28432.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    31. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med. 1997 Jul; 3(7):738-43. Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S. PMID: 9212099.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    32. Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha. J Biol Chem. 1997 Jan 17; 272(3):1548-57. Namchuk M, Lindsay L, Turck CW, Kanaani J, Baekkeskov S. PMID: 8999827.
      View in: PubMed   Mentions:
    33. Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase. J Immunol. 1996 Dec 01; 157(11):5208-14. Syren K, Lindsay L, Stoehrer B, Jury K, Lühder F, Baekkeskov S, Richter W. PMID: 8943434.
      View in: PubMed   Mentions:
    34. Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes. J Clin Invest. 1996 Jun 15; 97(12):2772-83. Aanstoot HJ, Kang SM, Kim J, Lindsay LA, Roll U, Knip M, Atkinson M, Mose-Larsen P, Fey S, Ludvigsson J, Landin L, Bruining J, Maclaren N, Akerblom HK, Baekkeskov S. PMID: 8675688; PMCID: PMC507370.
      View in: PubMed   Mentions:
    35. Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population. Diabetologia. 1994 Sep; 37(9):917-24. Aanstoot HJ, Sigurdsson E, Jaffe M, Shi Y, Christgau S, Grobbee D, Bruining GJ, Molenaar JL, Hofman A, Baekkeskov S. PMID: 7806022.
      View in: PubMed   Mentions:
    36. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. J Exp Med. 1994 Aug 01; 180(2):595-606. Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, Aanstoot HJ, Turck CW, Erlich H, Lennon V, Baekkeskov S. PMID: 7519242; PMCID: PMC2191592.
      View in: PubMed   Mentions:
    37. Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. J Cell Biol. 1994 Mar; 124(6):927-34. Shi Y, Veit B, Baekkeskov S. PMID: 8132714; PMCID: PMC2119982.
      View in: PubMed   Mentions:
    38. Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets. Diabetes. 1993 Dec; 42(12):1799-808. Kim J, Richter W, Aanstoot HJ, Shi Y, Fu Q, Rajotte R, Warnock G, Baekkeskov S. PMID: 8243826.
      View in: PubMed   Mentions:
    39. Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines. Mol Cell Biol. 1993 Jul; 13(7):4223-32. Radvanyi F, Christgau S, Baekkeskov S, Jolicoeur C, Hanahan D. PMID: 8391634; PMCID: PMC359972.
      View in: PubMed   Mentions:
    40. Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID). Diabetologia. 1993 Jun; 36(6):510-5. Petersen JS, Marshall MO, Baekkeskov S, Hejnaes KR, Høier-Madsen M, Dyrberg T. PMID: 8335172.
      View in: PubMed   Mentions:
    41. Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2832-6. Richter W, Shi Y, Baekkeskov S. PMID: 7681990; PMCID: PMC46190.
      View in: PubMed   Mentions:
    42. The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition. Autoimmunity. 1993; 15 Suppl:24-6. Baekkeskov S, Aanstoot HJ, Fu Q, Jaffe M, Kim J, Quan J, Richter W, Shi Y. PMID: 7692998.
      View in: PubMed   Mentions:
    43. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol. 1992 Aug; 6(8):1332-42. Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S. PMID: 1406710.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    44. Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. J Cell Biol. 1992 Jul; 118(2):309-20. Christgau S, Aanstoot HJ, Schierbeck H, Begley K, Tullin S, Hejnaes K, Baekkeskov S. PMID: 1321158; PMCID: PMC2290048.
      View in: PubMed   Mentions:
    45. Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. J Biol Chem. 1991 Dec 05; 266(34):23516. Christgau S, Schierbeck H, Aanstoot HJ, Aagaard L, Begley K, Kofod H, Hejnaes K, Baekkeskov S. PMID: 1744145.
      View in: PubMed   Mentions:
    46. Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. J Biol Chem. 1991 Nov 05; 266(31):21257-64. Christgau S, Schierbeck H, Aanstoot HJ, Aagaard L, Begley K, Kofod H, Hejnaes K, Baekkeskov S. PMID: 1939164.
      View in: PubMed   Mentions:
    47. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990 Sep 13; 347(6289):151-6. Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. PMID: 1697648.
      View in: PubMed   Mentions:
    48. Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. J Biol Chem. 1990 Jan 05; 265(1):376-81. Christie MR, Pipeleers DG, Lernmark A, Baekkeskov S. PMID: 2403561.
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    49. The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitus. Curr Top Microbiol Immunol. 1990; 164:143-68. Sigurdsson E, Baekkeskov S. PMID: 2073783.
      View in: PubMed   Mentions:
    50. Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes. 1989 Sep; 38(9):1133-41. Baekkeskov S, Warnock G, Christie M, Rajotte RV, Larsen PM, Fey S. PMID: 2670643.
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    51. Preclinical and manifest diabetes mellitus in young patients with Friedreich's ataxia: no evidence of immune process behind the islet cell destruction. Diabetologia. 1989 Jun; 32(6):378-81. Schoenle EJ, Boltshauser EJ, Baekkeskov S, Landin Olsson M, Torresani T, von Felten A. PMID: 2668085.
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    52. Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Res. 1989 Feb; 10(2):53-7. Hansen WA, Christie MR, Kahn R, Norgaard A, Abel I, Petersen AM, Jorgensen DW, Baekkeskov S, Nielsen JH, Lernmark A, et al. PMID: 2545405.
      View in: PubMed   Mentions:
    53. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9037-41. Efrat S, Linde S, Kofod H, Spector D, Delannoy M, Grant S, Hanahan D, Baekkeskov S. PMID: 2848253; PMCID: PMC282658.
      View in: PubMed   Mentions:
    54. Antibodies to a Mr-64,000 islet cell protein in Swedish children with newly diagnosed type 1 (insulin-dependent) diabetes. Diabetologia. 1988 Aug; 31(8):597-602. Christie M, Landin-Olsson M, Sundkvist G, Dahlquist G, Lernmark A, Baekkeskov S. PMID: 3065114.
      View in: PubMed   Mentions:
    55. Studies of the isolation and viability of human islets of Langerhans. Transplantation. 1988 May; 45(5):957-63. Warnock GL, Ellis D, Rajotte RV, Dawidson I, Baekkeskov S, Egebjerg J. PMID: 2835843.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    56. [Spontaneous diabetes and diabetes induced by streptozotocin in the rat and mouse]. Journ Annu Diabetol Hotel Dieu. 1988; 15-31. Lernmark A, Markholst H, Laursen H, Contreas G, Altieri M, Baekkeskov S, Herold R, Kastern W, Madsen OD. PMID: 2971832.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    57. Islet-specific immune mechanisms. Diabetes Metab Rev. 1987 Oct; 3(4):959-80. Lernmark A, Li S, Baekkeskov S, Christie M, Michelsen B, Ursing J, Olsson ML, Sundkvist G. PMID: 3315527.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    58. Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes. EMBO J. 1987 Sep; 6(9):2699-704. Efrat S, Baekkeskov S, Lane D, Hanahan D. PMID: 2824189; PMCID: PMC553692.
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    59. Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest. 1987 Mar; 79(3):926-34. Baekkeskov S, Landin M, Kristensen JK, Srikanta S, Bruining GJ, Mandrup-Poulsen T, de Beaufort C, Soeldner JS, Eisenbarth G, Lindgren F, et al. PMID: 3546382; PMCID: PMC424239.
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    60. Islet cell and 64K autoantibodies are associated with plasma IgG in newly diagnosed insulin-dependent diabetic children. J Immunol. 1986 Dec 15; 137(12):3782-5. Gerling I, Baekkeskov S, Lernmark A. PMID: 3537124.
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    61. Immunoreactivity to a 64,000 Mr human islet cell antigen in sera from insulin-dependent diabetes mellitus patients and individuals with abnormal glucose tolerance. Mol Biol Med. 1986 Apr; 3(2):137-42. Baekkeskov S. PMID: 3526081.
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    62. Immunological aspects of type 1 and 2 diabetes mellitus. Adv Exp Med Biol. 1985; 189:107-27. Lernmark A, Baekkeskov S, Gerling I, Kastern W, Knutson C, Michelsen B. PMID: 4036712.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    63. [Mechanism and genetic control of the autoimmune response directed against beta-pancreatic cells in insulin-dependent diabetes]. Journ Annu Diabetol Hotel Dieu. 1985; 171-82. Michelsen B, Baekkeskov S, Deufel T, Kastern W, Kofod H, Lernmark A, Vissing H. PMID: 2577960.
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    64. A beta-cell glycoprotein of Mr 40 000 is the major rat islet cell immunogen following xenogenic immunisation. Diabetologia. 1984 Jul; 27 Suppl:70-3. Baekkeskov S, Lernmark A. PMID: 6383923.
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    65. Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science. 1984 Jun 22; 224(4655):1348-50. Baekkeskov S, Dyrberg T, Lernmark A. PMID: 6374896.
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    66. Glucose stimulates the biosynthesis of a human pancreatic islet cell protein detected by an antiserum against the human erythrocyte glucose transporter. FEBS Lett. 1983 Jul 04; 157(2):331-5. Baekkeskov S, Lernmark A. PMID: 6190679.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    67. Immunoglobulin from insulin-dependent diabetic children inhibits glucose-induced insulin release. Diabetes. 1983 Jun; 32(6):520-4. Kanatsuna T, Baekkeskov S, Lernmark A, Ludvigsson J. PMID: 6354781.
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    68. Role of islet cell antibodies in the pathogenesis of type I diabetes. Curr Probl Clin Biochem. 1983; 12:65-85. Brogren CH, Baekkeskov S, Dyrberg T, Lernmark A, Marner B, Nerup J, Papadopoulos GK. PMID: 6360543.
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    69. Specific pancreatic beta-cell surface antigens recognized by a xenogenic antiserum. J Cell Biol. 1982 Aug; 94(2):472-7. Dyrberg T, Baekkeskov S, Lernmark A. PMID: 7050130; PMCID: PMC2112876.
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    70. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature. 1982 Jul 08; 298(5870):167-9. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark A. PMID: 7045690.
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    71. Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat. Diabetes. 1982 Mar; 31(3):278-81. Dyrberg T, Nakhooda AF, Baekkeskov S, Lernmark A, Poussier P, Marliss EB. PMID: 6759244.
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    72. Rodent islet cell antigens recognized by antibodies in sera from diabetic patients. Acta Biol Med Ger. 1982; 41(12):1111-5. Baekkeskov S, Lernmark A. PMID: 6765152.
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    73. Islet cell antibodies-theoretical and practical implications. Diabetologia. 1981 Nov; 21(5):431-5. Lernmark A, Baekkeskov S. PMID: 7028555.
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    74. Expression of major histocompatibility antigens on pancreatic islet cells. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6456-60. Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. PMID: 7031653; PMCID: PMC349058.
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    75. Islet transplantation in mice differing in the I and S subregions of the H-2 complex. Transplantation. 1981 Jun; 31(6):476-9. Steffes MW, Nielsen O, Dyrberg T, Baekkeskov S, Scott J, Lernmark A. PMID: 6789509.
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