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Steinunn Baekkeskov, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentDiabetes Center
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-6267
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    GENERATION OF A NON-HUMAN PRIMATE MODEL TYPE
    NIH/NIDDK R21DK055977Sep 30, 1999 - Aug 31, 2002
    Role: Principal Investigator
    IMMUNOPATHOLOGY OF BETA CELL AUTOANTIGENS
    NIH/NIDDK R01DK047043Apr 1, 1994 - Mar 31, 2003
    Role: Principal Investigator
    MOLECULAR CHARACTERIZATION OF B-CELL MEMBRANE ANTIGENS
    NIH/NIDDK R55DK041567Sep 30, 1991 - Sep 29, 1993
    Role: Principal Investigator
    CELL AND MOLECULAR BIOLOGY OF THE PANCREATIC ISLET CELLS
    NIH P01DK041822Aug 1, 1989 - Jul 31, 2001
    Role: Co-Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baekkeskov S, Hubbell JA, Phelps EA. Bioengineering strategies for inducing tolerance in autoimmune diabetes. Adv Drug Deliv Rev. 2017 May 15; 114:256-265. PMID: 28625830.
      View in: PubMed
    2. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 05 09; 7:46801. PMID: 28485397.
      View in: PubMed
    3. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 Apr 12; 7:45961. PMID: 28401888.
      View in: PubMed
    4. Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S. Primary Human and Rat ß-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. Diabetes. 2017 02; 66(2):460-473. PMID: 27872147.
      View in: PubMed
    5. Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S. Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity. Diabetes. 2016 09; 65(9):2686-99. PMID: 27284108; PMCID: PMC5001175 [Available on 09/01/17].
      View in: PubMed, PubMed Central
    6. Kanaani J, Cianciaruso C, Phelps EA, Pasquier M, Brioudes E, Billestrup N, Baekkeskov S. Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons. PLoS One. 2015; 10(2):e0117130. PMID: 25647668; PMCID: PMC4315522.
      View in: PubMed, PubMed Central
    7. Kanaani J, Kolibachuk J, Martinez H, Baekkeskov S. Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters. J Cell Biol. 2010 Sep 06; 190(5):911-25. PMID: 20805323; PMCID: PMC2935578.
      View in: PubMed, PubMed Central
    8. Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC. Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun. 2009 Aug; 33(1):50-7. PMID: 19289270; PMCID: PMC2705176.
      View in: PubMed, PubMed Central
    9. Baekkeskov S, Kanaani J. Palmitoylation cycles and regulation of protein function (Review). Mol Membr Biol. 2009 Jan; 26(1):42-54. PMID: 19169934.
      View in: PubMed
    10. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49. PMID: 18230651.
      View in: PubMed
    11. Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G. Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Neurochem. 2005 Dec; 95(5):1373-86. PMID: 16313516.
      View in: PubMed
    12. Kanaani J, Diacovo MJ, El-Husseini Ael-D, Bredt DS, Baekkeskov S. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. J Cell Sci. 2004 Apr 15; 117(Pt 10):2001-13. PMID: 15039456.
      View in: PubMed
    13. Kanaani J, el-Husseini Ael-D, Aguilera-Moreno A, Diacovo JM, Bredt DS, Baekkeskov S. A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65. J Cell Biol. 2002 Sep 30; 158(7):1229-38. PMID: 12356867; PMCID: PMC2173248.
      View in: PubMed, PubMed Central
    14. Jaume JC, Parry SL, Madec AM, Sønderstrup G, Baekkeskov S. Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. J Immunol. 2002 Jul 15; 169(2):665-72. PMID: 12097368.
      View in: PubMed
    15. Wolfe T, Bot A, Hughes A, Möhrle U, Rodrigo E, Jaume JC, Baekkeskov S, von Herrath M. Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety. Eur J Immunol. 2002 Jan; 32(1):113-21. PMID: 11754351.
      View in: PubMed
    16. Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol. 1992 Aug; 6(8):1332-42. PMID: 1406710.
      View in: PubMed
    17. Warnock GL, Ellis D, Rajotte RV, Dawidson I, Baekkeskov S, Egebjerg J. Studies of the isolation and viability of human islets of Langerhans. Transplantation. 1988 May; 45(5):957-63. PMID: 2835843.
      View in: PubMed
    18. Lernmark A, Markholst H, Laursen H, Contreas G, Altieri M, Baekkeskov S, Herold R, Kastern W, Madsen OD. [Spontaneous diabetes and diabetes induced by streptozotocin in the rat and mouse]. Journ Annu Diabetol Hotel Dieu. 1988; 15-31. PMID: 2971832.
      View in: PubMed
    19. Lernmark A, Li S, Baekkeskov S, Christie M, Michelsen B, Ursing J, Olsson ML, Sundkvist G. Islet-specific immune mechanisms. Diabetes Metab Rev. 1987 Oct; 3(4):959-80. PMID: 3315527.
      View in: PubMed
    20. Lernmark A, Baekkeskov S, Gerling I, Kastern W, Knutson C, Michelsen B. Immunological aspects of type 1 and 2 diabetes mellitus. Adv Exp Med Biol. 1985; 189:107-27. PMID: 4036712.
      View in: PubMed
    21. Baekkeskov S, Lernmark A. Glucose stimulates the biosynthesis of a human pancreatic islet cell protein detected by an antiserum against the human erythrocyte glucose transporter. FEBS Lett. 1983 Jul 04; 157(2):331-5. PMID: 6190679.
      View in: PubMed
    22. Lernmark A, Baekkeskov S. Islet cell antibodies-theoretical and practical implications. Diabetologia. 1981 Nov; 21(5):431-5. PMID: 7028555.
      View in: PubMed
    23. Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. Expression of major histocompatibility antigens on pancreatic islet cells. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6456-60. PMID: 7031653; PMCID: PMC349058.
      View in: PubMed, PubMed Central
    24. Steffes MW, Nielsen O, Dyrberg T, Baekkeskov S, Scott J, Lernmark A. Islet transplantation in mice differing in the I and S subregions of the H-2 complex. Transplantation. 1981 Jun; 31(6):476-9. PMID: 6789509.
      View in: PubMed
    25. Rovis L, Baekkeskov S. Sub-cellular fractionation of Trypanosoma brucei. Isolation and characterization of plasma membranes. Parasitology. 1980 Jun; 80(3):507-24. PMID: 6248830.
      View in: PubMed
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