William Hyun, MS

Title(s)Professional Researcher, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW, #1201
San Francisco CA 94143
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    Collapse Biography 
    Collapse Awards and Honors
    National Science Foundation1981Special Achievement Award
    University of Debrecen, Hungary1986Fulbright Specialist
    Shanghai Medical University1989Honorary PhD Cell Biology
    Iwate Medical University, Japan1992Honorary PhD Medical Science
    R&D 100 Product of the Year2005Zeiss Meta Spectral Confocal Microscope
    Red Dot Design Award2014Sony Spectral Cell Analyzer
    Mission Bio2016CYTO Technology Award Winner
    Akadeum Biosciences2017CYTO Technology Award Winner

    Collapse Overview 
    Collapse Overview
    William Hyun is an expert in the field of cytometry, specialized in the technical areas of flow cytometry and cell sorting, confocal and digital microscopy, high-content and high-throughput screening, in vivo small animal imaging, encoded array systems, biomarkers and bioinformatics. Hyun has worked in the field of cytometry for more than twenty-five (25) years, nineteen (19) years as Director of the Laboratory for Cell Analysis (LCA). In 2014, Hyun initiated and was appointed Director of the Laboratory for Advanced Cytometry (LAC) and Director of the Sony Biotechnology Center in the Department of Laboratory Medicine. Hyun has past appointments in the Biomedical Sciences (BMS) and Tetrad Graduate Programs, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and Affiliate Scientist appointments at Lawrence Berkeley National Lab (LBNL) and UC Berkeley (UCB). The LAC and Sony Biotechnology Center are focused on translating research science into the clinical cytology and pathology labs. Technology translation includes assay validation, development of CLIA/FDA approval processes, QC/QA procedures, automation and robotics, reimbursement coding, data handling, multiparametric data analysis and advanced presentation of results.
    Other technology areas include development of nanochips for soluble microanalysis and microfluidic chips for genomic and cytometric assays. The first effort in cellular bar coding resulted in the formation of a commercial company, Vitra Biosciences. Other efforts include encoded micro-fabricated chips, commercialized by True Materials, a startup housed in the UCSF QB3 Incubator and eventually purchased by Affymetrix. Another program has been investigating the use of bioscaffolds and molecular assembly along with 3D bio-printing for use in cytometric assays for stem cell engraftment, directional cell growth, surgical repair, and organoids for high content imaging assays like cellular invasion, migration and maturation studies. Some of this work is now commercialized by Fibralign Corporation. Working with the UCSF Abate lab, new partitioning technologies are being implemented for refined multiplex genomic and proteomic analysis at the single cell and single molecule level. Three commercial companies, Mission Bio, Scribe Bio and Fluent Biosciences, were founded to commercialize UCSF IP. Other developmental projects include mass spec flow and mass image cytometry, buoyancy bubble-based cell isolation (Akadeum Bio), single cell Western blot technology from the Herr lab at UC Berkeley (Zephyrus Bio, now BioTechne), and clinical single cell genomic diagnostics for oncology/pathology.
    Hyun is an angel investor/co-founder in several biotech startup companies, and currently sits on the Board of Mission Bio, Scribe Bio, Newbridge Media, Akadeum Biosciences, Fluent Bio and the Scientific Advisory Board of Fibralign Corporation, Intabio, and CellFe. Hyun is a venture partner at Genoa Ventures focused on early stage investments where biology meets technology. Hyun has current and past compensated consulting roles with ZEISS and CRI in the area of spectral microscopy, Becton Dickinson, Sony and Danaher Corporations in the area of flow cytometry and cell sorting, Bristol Meyer Squibb and Sanofi-Aventis/Regeneron in the area of high content screening. Past positions include investor/advisor to Accuri Cytometers, Vitra Biosciences, KAIROS, SEQ, True Materials, Biotrue, Symbiosis Biowares, and Unihart Biotech Pharma.
    Hyun has authored over 100 peer-reviewed publications.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Strategies for enrichment and selection of stem cell-derived tissue precursors. Stem Cell Res Ther. 2012 May 10; 3(3):17. Bernstein HS, Hyun WC. PMID: 22575029; PMCID: PMC3392764.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    2. Distinctive features of angiogenesis and lymphangiogenesis determine their functionality during de novo tumor development. Cancer Res. 2007 Jun 01; 67(11):5211-20. Eichten A, Hyun WC, Coussens LM. PMID: 17545601.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    3. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006 May 01; 107(9):3716-23. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. PMID: 16418334; PMCID: PMC1895776.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    4. Novel calibration method for flow cytometric fluorescence resonance energy transfer measurements between visible fluorescent proteins. Cytometry A. 2005 Oct; 67(2):86-96. Nagy P, Bene L, Hyun WC, Vereb G, Braun M, Antz C, Paysan J, Damjanovich S, Park JW, Szöllosi J. PMID: 16163690.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    5. Biphasic calcium response of platelet-derived growth factor stimulated glioblastoma cells is a function of cell confluence. Cytometry A. 2005 Oct; 67(2):172-9. Vereb G, Feuerstein BG, Hyun WC, Fulwyler MJ, Balázs M, Szöllosi J. PMID: 16163701.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines. Thyroid. 2005 Mar; 15(3):222-31. Park JW, Zarnegar R, Kanauchi H, Wong MG, Hyun WC, Ginzinger DG, Lobo M, Cotter P, Duh QY, Clark OH. PMID: 15785241.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    7. Modulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by chemotherapy in thyroid cancer cell lines. Thyroid. 2003 Dec; 13(12):1103-10. Park JW, Wong MG, Lobo M, Hyun WC, Duh QY, Clark OH. PMID: 14751030.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines. J Clin Endocrinol Metab. 2003 Jul; 88(7):3346-53. Park JW, Yeh MW, Wong MG, Lobo M, Hyun WC, Duh QY, Clark OH. PMID: 12843186.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    9. Persistent oxidative stress in chromosomally unstable cells. Cancer Res. 2003 Jun 15; 63(12):3107-11. Limoli CL, Giedzinski E, Morgan WF, Swarts SG, Jones GD, Hyun W. PMID: 12810636.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    10. Alterations of neutrophil f-actin kinetics by tobacco smoke: implications for periodontal diseases. J Periodontal Res. 2002 Aug; 37(4):286-92. Ryder MI, Wu TC, Kallaos SS, Hyun W. PMID: 12200973.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle. BMC Cell Biol. 2002 Mar 21; 3:6. Liu W, Enwright JF, Hyun W, Day RN, Schaufele F. PMID: 11914124; PMCID: PMC101385.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status. Am J Pathol. 2002 Jan; 160(1):151-64. Kobayashi A, Darragh T, Herndier B, Anastos K, Minkoff H, Cohen M, Young M, Levine A, Grant LA, Hyun W, Weinberg V, Greenblatt R, Smith-McCune K. PMID: 11786409; PMCID: PMC1867118.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
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