Frederick Chang, PhD, MD
|School||UCSF School of Dentistry|
|Department||Cell and Tissue Biology|
|Address||513 Parnassus Ave|
San Francisco CA 94143
The Chang Lab studies fundamental questions concerning spatial organization within a single cell: How are cell shape and size determined? How do cells sense their own size, or their shape? How do molecules and cell mechanics contribute to determine the growth, size and shape of cells? To address these questions, we study primarily a simple eukaryotic model organism, the fission yeast Schizosaccharomyces pombe. These are rod-shaped cells that display a highly uniform size and rod-shaped morphology. We seek to elucidate quantitative molecular and biomechanical mechanisms underlying the dynamic cellular processes responsible for cell morphogenesis. Many of our studies use live cell imaging and image analyses to develop quantitative models. We use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, engineers and modelers.
Current projects include: regulation of cell size, mechanism of cell wall assembly, turgor pressure and shape, cytokinesis and the actin-based contractile ring, cell polarity and regulation of microtubule dynamics.
Cell biology; Cell Shape and Morphogenesis; Cytokinesis; Microtubules; Actin; Cell Size Control; Fission Yeast Schizosaccharomyces pombe
Derived automatically from this person's publications.