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    Frederick Chang, PhD, MD

    SchoolUCSF School of Dentistry
    DepartmentCell and Tissue Biology
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      Princeton UniversityABBiology1984
      UCSFMD PhDBiochemistry/Biophysics1992
      Oxford UniversityPostdoc1994
      UC BerkeleyPostdocMolecular Cellular Biology1996

      Collapse Overview 
      Collapse Overview
      The Chang Lab studies fundamental questions concerning spatial organization within a single cell: How are cell shape and size determined? How do cells sense their own size, or their shape? How do molecules and cell mechanics contribute to determine the growth, size and shape of cells? To address these questions, we study primarily the fission yeast Schizosaccharomyces pombe. These are rod-shaped eukaryotic cells that display a highly uniform size and morphology. Many of our studies use live cell imaging and image analyses to develop quantitative models. We use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, engineers and modelers. Current projects include: regulation of cell size, mechanisms of cell wall assembly, turgor pressure and shape, cytokinesis and the actin-based contractile ring, cell polarity and regulation of microtubule dynamics.

      Collapse Interests
      Cell biology; Cell Shape and Morphogenesis; Cytokinesis; Microtubules; Actin; Cell Size Control; Fission Yeast Schizosaccharomyces pombe

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Atilgan E, Magidson V, Khodjakov A, Chang F. Morphogenesis of the Fission Yeast Cell through Cell Wall Expansion. Curr Biol. 2015 Aug 17; 25(16):2150-7. PMID: 26212881; PMCID: PMC4627367.
      2. Haupt A, Campetelli A, Bonazzi D, Piel M, Chang F, Minc N. Electrochemical regulation of budding yeast polarity. PLoS Biol. 2014 Dec; 12(12):e1002029. PMID: 25548923; PMCID: PMC4280105.
      3. Zhou Z, Munteanu EL, He J, Ursell T, Bathe M, Huang KC, Chang F. The contractile ring coordinates curvature-dependent septum assembly during fission yeast cytokinesis. Mol Biol Cell. 2015 Jan 1; 26(1):78-90. PMID: 25355954; PMCID: PMC4279231.
      4. Chang F, Huang KC. How and why cells grow as rods. BMC Biol. 2014 Aug 02; 12:54. PMID: 25185019; PMCID: PMC4243964.
      5. Chang F, Minc N. Electrochemical control of cell and tissue polarity. Annu Rev Cell Dev Biol. 2014; 30:317-36. PMID: 25062359.
        View in: PubMed
      6. Pan KZ, Saunders TE, Flor-Parra I, Howard M, Chang F. Cortical regulation of cell size by a sizer cdr2p. Elife. 2014 Mar 18; 3:e02040. PMID: 24642412; PMCID: PMC3956294.
      7. Basu R, Munteanu EL, Chang F. Role of turgor pressure in endocytosis in fission yeast. Mol Biol Cell. 2014 Mar; 25(5):679-87. PMID: 24403609; PMCID: PMC3937093.
      8. Chang F, Atilgan E, Burgess D, Minc N. Manipulating cell shape by placing cells into micro-fabricated chambers. Methods Mol Biol. 2014; 1136:281-90. PMID: 24633802.
        View in: PubMed
      9. Hou H, Zhou Z, Wang Y, Wang J, Kallgren SP, Kurchuk T, Miller EA, Chang F, Jia S. Csi1 links centromeres to the nuclear envelope for centromere clustering. J Cell Biol. 2012 Nov 26; 199(5):735-44. PMID: 23166349; PMCID: PMC3514793.
      10. Atilgan E, Burgess D, Chang F. Localization of cytokinesis factors to the future cell division site by microtubule-dependent transport. Cytoskeleton (Hoboken). 2012 Nov; 69(11):973-82. PMID: 23001894; PMCID: PMC3593075.
      11. Proctor SA, Minc N, Boudaoud A, Chang F. Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast. Curr Biol. 2012 Sep 11; 22(17):1601-8. PMID: 22840513; PMCID: PMC3443309.
      12. Basu R, Chang F. Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis. Curr Biol. 2011 Jun 7; 21(11):905-16. PMID: 21620704; PMCID: PMC3121306.
      13. Minc N, Burgess D, Chang F. Influence of cell geometry on division-plane positioning. Cell. 2011 Feb 4; 144(3):414-26. PMID: 21295701; PMCID: PMC3048034.
      14. Minc N, Chang F. Electrical control of cell polarization in the fission yeast Schizosaccharomyces pombe. Curr Biol. 2010 Apr 27; 20(8):710-6. PMID: 20362451; PMCID: PMC2900468.
      15. Yonetani A, Chang F. Regulation of cytokinesis by the formin cdc12p. Curr Biol. 2010 Mar 23; 20(6):561-6. PMID: 20226666; PMCID: PMC2845737.
      16. Pan KZ, Chang F. Cell-cycle control: don't supersize me. Curr Biol. 2009 Jul 14; 19(13):R517-9. PMID: 19602414.
        View in: PubMed
      17. Chang F, Martin SG. Shaping fission yeast with microtubules. Cold Spring Harb Perspect Biol. 2009 Jul; 1(1):a001347. PMID: 20066076; PMCID: PMC2742080.
      18. Minc N, Boudaoud A, Chang F. Mechanical forces of fission yeast growth. Curr Biol. 2009 Jul 14; 19(13):1096-101. PMID: 19500986; PMCID: PMC2790036.
      19. Minc N, Bratman SV, Basu R, Chang F. Establishing new sites of polarization by microtubules. Curr Biol. 2009 Jan 27; 19(2):83-94. PMID: 19147354; PMCID: PMC2820583.
      20. Bratman SV, Chang F. Mechanisms for maintaining microtubule bundles. Trends Cell Biol. 2008 Dec; 18(12):580-6. PMID: 18951798.
        View in: PubMed
      21. Yonetani A, Lustig RJ, Moseley JB, Takeda T, Goode BL, Chang F. Regulation and targeting of the fission yeast formin cdc12p in cytokinesis. Mol Biol Cell. 2008 May; 19(5):2208-19. PMID: 18305104; PMCID: PMC2366869.
      22. Bratman SV, Chang F. Stabilization of overlapping microtubules by fission yeast CLASP. Dev Cell. 2007 Dec; 13(6):812-27. PMID: 18061564; PMCID: PMC2215317.
      23. Martin SG, Rincón SA, Basu R, Pérez P, Chang F. Regulation of the formin for3p by cdc42p and bud6p. Mol Biol Cell. 2007 Oct; 18(10):4155-67. PMID: 17699595; PMCID: PMC1995706.
      24. Basu R, Chang F. Shaping the actin cytoskeleton using microtubule tips. Curr Opin Cell Biol. 2007 Feb; 19(1):88-94. PMID: 17194581.
        View in: PubMed
      25. Padte NN, Martin SG, Howard M, Chang F. The cell-end factor pom1p inhibits mid1p in specification of the cell division plane in fission yeast. Curr Biol. 2006 Dec 19; 16(24):2480-7. PMID: 17140794.
        View in: PubMed
      26. Daga RR, Lee KG, Bratman S, Salas-Pino S, Chang F. Self-organization of microtubule bundles in anucleate fission yeast cells. Nat Cell Biol. 2006 Oct; 8(10):1108-13. PMID: 16998476.
        View in: PubMed
      27. Daga RR, Yonetani A, Chang F. Asymmetric microtubule pushing forces in nuclear centering. Curr Biol. 2006 Aug 8; 16(15):1544-50. PMID: 16890530.
        View in: PubMed
      28. Martin SG, Chang F. Dynamics of the formin for3p in actin cable assembly. Curr Biol. 2006 Jun 20; 16(12):1161-70. PMID: 16782006.
        View in: PubMed
      29. Martin SG, Chang F. New end take off: regulating cell polarity during the fission yeast cell cycle. Cell Cycle. 2005 Aug; 4(8):1046-9. PMID: 15970692.
        View in: PubMed
      30. Takeda T, Chang F. Role of fission yeast myosin I in organization of sterol-rich membrane domains. Curr Biol. 2005 Jul 26; 15(14):1331-6. PMID: 16051179.
        View in: PubMed
      31. Daga RR, Chang F. Dynamic positioning of the fission yeast cell division plane. Proc Natl Acad Sci U S A. 2005 Jun 7; 102(23):8228-32. PMID: 15928091; PMCID: PMC1142117.
      32. Martin SG, McDonald WH, Yates JR, Chang F. Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity. Dev Cell. 2005 Apr; 8(4):479-91. PMID: 15809031.
        View in: PubMed
      33. Zimmerman S, Chang F. Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast. Mol Biol Cell. 2005 Jun; 16(6):2719-33. PMID: 15772152; PMCID: PMC1142419.
      34. Chang F, Feierbach B, Martin S. Regulation of actin assembly by microtubules in fission yeast cell polarity. Novartis Found Symp. 2005; 269:59-66; discussion 66-72, 223-30. PMID: 16355535.
        View in: PubMed
      35. Zimmerman S, Daga RR, Chang F. Intra-nuclear microtubules and a mitotic spindle orientation checkpoint. Nat Cell Biol. 2004 Dec; 6(12):1245-6. PMID: 15573098.
        View in: PubMed
      36. Takeda T, Kawate T, Chang F. Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast. Nat Cell Biol. 2004 Nov; 6(11):1142-4. PMID: 15517003.
        View in: PubMed
      37. Feierbach B, Verde F, Chang F. Regulation of a formin complex by the microtubule plus end protein tea1p. J Cell Biol. 2004 Jun 7; 165(5):697-707. PMID: 15184402; PMCID: PMC2172381.
      38. Zimmerman S, Tran PT, Daga RR, Niwa O, Chang F. Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle. Dev Cell. 2004 Apr; 6(4):497-509. PMID: 15068790.
        View in: PubMed
      39. Chang F, Re F, Sebastian S, Sazer S, Luban J. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. Mol Biol Cell. 2004 Apr; 15(4):1793-801. PMID: 14767062; PMCID: PMC379276.
      40. Martin SG, Chang F. Cell polarity: a new mod(e) of anchoring. Curr Biol. 2003 Sep 16; 13(18):R711-3. PMID: 13678610.
        View in: PubMed
      41. Chang F, Burgess D. The contractile ring. Curr Biol. 2003 Sep 16; 13(18):R692-3. PMID: 13678603.
        View in: PubMed
      42. Chang F, Peter M. Yeasts make their mark. Nat Cell Biol. 2003 Apr; 5(4):294-9. PMID: 12669083.
        View in: PubMed
      43. Berlin A, Paoletti A, Chang F. Mid2p stabilizes septin rings during cytokinesis in fission yeast. J Cell Biol. 2003 Mar 31; 160(7):1083-92. PMID: 12654901; PMCID: PMC2172768.
      44. Pelham RJ, Chang F. Actin dynamics in the contractile ring during cytokinesis in fission yeast. Nature. 2002 Sep 5; 419(6902):82-6. PMID: 12214236.
        View in: PubMed
      45. Chang F, Peter M. Cell biology. Formins set the record straight. Science. 2002 Jul 26; 297(5581):531-2. PMID: 12142518.
        View in: PubMed
      46. Paoletti A, Chang F. Analysis of mid1p, a protein required for placement of the cell division site, reveals a link between the nucleus and the cell surface in fission yeast. Mol Biol Cell. 2000 Aug; 11(8):2757-73. PMID: 10930468; PMCID: PMC14954.
      47. Chang F, Drubin D, Nurse P. cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin. J Cell Biol. 1997 Apr 7; 137(1):169-82. PMID: 9105045; PMCID: PMC2139860.
      48. Chang F, Nurse P. How fission yeast fission in the middle. Cell. 1996 Jan 26; 84(2):191-4. PMID: 8565064.
        View in: PubMed
      49. Chang F, Woollard A, Nurse P. Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring. J Cell Sci. 1996 Jan; 109 ( Pt 1):131-42. PMID: 8834798.
        View in: PubMed
      50. Chang F, Nurse P. Finishing the cell cycle: control of mitosis and cytokinesis in fission yeast. Trends Genet. 1993 Oct; 9(10):333-5. PMID: 8273144.
        View in: PubMed
      51. Chang F, Herskowitz I. Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. Mol Biol Cell. 1992 Apr; 3(4):445-50. PMID: 1498364; PMCID: PMC275594.
      52. Herskowitz I, Ogas J, Andrews BJ, Chang F. Regulators of synthesis and activity of the G1 cyclins of budding yeast. Cold Spring Harb Symp Quant Biol. 1991; 56:33-40. PMID: 1840254.
        View in: PubMed
      53. Chang F, Herskowitz I. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell. 1990 Nov 30; 63(5):999-1011. PMID: 2147873.
        View in: PubMed
      54. Neiman AM, Chang F, Komachi K, Herskowitz I. CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Cell Regul. 1990 Apr; 1(5):391-401. PMID: 2099190; PMCID: PMC361514.
      55. Masters SB, Miller RT, Chi MH, Chang FH, Beiderman B, Lopez NG, Bourne HR. Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. J Biol Chem. 1989 Sep 15; 264(26):15467-74. PMID: 2549064.
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      56. Chang FH, Bourne HR. Cholera toxin induces cAMP-independent degradation of Gs. J Biol Chem. 1989 Apr 5; 264(10):5352-7. PMID: 2538415.
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      57. Yu VC, Hochhaus G, Chang FH, Richards ML, Bourne HR, Sadée W. Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid. J Neurochem. 1988 Dec; 51(6):1892-9. PMID: 2903224.
        View in: PubMed
      58. Chang FH, Bourne HR. Dexamethasone increases adenylyl cyclase activity and expression of the alpha-subunit of Gs in GH3 cells. Endocrinology. 1987 Nov; 121(5):1711-5. PMID: 3665842.
        View in: PubMed
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