John Gross, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th St, #S512E
San Francisco CA 94158
Phone415-502-1897
ORCID ORCID Icon0000-0002-1377-4705 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical School, Boston, MAPostdoctoral2003Biological Chemistry
    Massachusetts Institute of Technology, Cambridge, MAPh.D.1998Chemistry
    University of the South, Sewanee, TNB.S.1992Chemistry
    University of California, San Francisco2021Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
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    We investigate molecular machines that coordinate gene expression or antiviral immunity. Research areas include : i- RNA decay enzymes that act in mRNA quality control and gene regulatory pathways, and ii- nucleic acid based immune systems that protect animals from viruses and neutralization of these systems by viral accessory proteins. We use tools from molecular biophysics to understand the structure and regulatory conformational dynamics in these systems with the ultimate goal of defining molecular mechanisms and avenues for structure based drug design.
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    A 600 MHz NMR console and cryoprobe for studies of macromolecules, drug discovery and cancer biomarkers
    NIH S10OD023455Sep 17, 2018 - Sep 16, 2019
    Role: Principal Investigator
    Conformational Control of Heterochromatin Formation by the HP-1 Protein from Fission Yeast
    NIH R01GM121962Sep 30, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Developing Small Molecule Screens for Vif-APOBEC3 antagonists
    NIH R21AI118528May 1, 2015 - Apr 30, 2018
    Role: Principal Investigator
    A Combined 600 MHz NMR Console for Studies of Cell Extracts and Biological Solids
    NIH S10RR026415Sep 13, 2010 - Mar 12, 2013
    Role: Principal Investigator
    Structure and Function of the Decapping Enzyme Complex
    NIH R01GM078360Dec 1, 2008 - Feb 29, 2020
    Role: Principal Investigator
    HARC Center: HIV Accessory and Regulatory Complexes
    NIH P50GM082250Aug 27, 2007 - Aug 31, 2022
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk. Sci Adv. 2024 Jan 19; 10(3):eadi4162. Li Y, Liu X, Fujinaga K, Gross JD, Frankel AD. PMID: 38241362; PMCID: PMC10798561.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature. 2023 03; 615(7953):728-733. Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD. PMID: 36754086; PMCID: PMC10033410.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    3. A call to order: Examining structured domains in biomolecular condensates. J Magn Reson. 2023 01; 346:107318. Tibble RW, Gross JD. PMID: 36657879; PMCID: PMC10878105.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. PLoS Pathog. 2022 09; 18(9):e1010811. Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E. PMID: 36095012; PMCID: PMC9499238.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    5. Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. ACS Chem Biol. 2022 06 17; 17(6):1460-1471. Bednarczyk M, Peters JK, Kasprzyk R, Starek J, Warminski M, Spiewla T, Mugridge JS, Gross JD, Jemielity J, Kowalska J. PMID: 35576528; PMCID: PMC9207806.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis. Structure. 2022 05 05; 30(5):721-732.e4. Peters JK, Tibble RW, Warminski M, Jemielity J, Gross JD. PMID: 35290794; PMCID: PMC9081138.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    7. SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. bioRxiv. 2022 Jan 05. Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E. PMID: 35018374; PMCID: PMC8750649.
      View in: PubMed   Mentions:
    8. Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes. PLoS One. 2021; 16(5):e0250318. Sevillano N, Green EM, Votteler J, Kim DY, Ren X, Yang B, Liu X, Lourenço AL, Hurley JH, Farr-Jones S, Gross JD, Cheng Y, Craik CS. PMID: 33983947; PMCID: PMC8118348.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation. Nat Chem Biol. 2021 05; 17(5):615-623. Tibble RW, Depaix A, Kowalska J, Jemielity J, Gross JD. PMID: 33767388; PMCID: PMC8476181.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    10. Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 02 19; 16(2):334-343. Warminski M, Kowalska J, Nowak E, Kubacka D, Tibble R, Kasprzyk R, Sikorski PJ, Gross JD, Nowotny M, Jemielity J. PMID: 33439620; PMCID: PMC7901015.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. Pdc2/Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex. RNA. 2020 10; 26(10):1380-1388. Lobel JH, Gross JD. PMID: 32513655; PMCID: PMC7491320.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Biophysical Properties of HP1-Mediated Heterochromatin. Cold Spring Harb Symp Quant Biol. 2019; 84:217-225. Sanulli S, Gross JD, Narlikar GJ. PMID: 32493764; PMCID: PMC9128075.
      View in: PubMed   Mentions: 8     Fields:    
    13. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 2284     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism. Cell Host Microbe. 2019 12 11; 26(6):739-747.e4. Binning JM, Chesarino NM, Emerman M, Gross JD. PMID: 31830442; PMCID: PMC6913891.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Pat1 activates late steps in mRNA decay by multiple mechanisms. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23512-23517. Lobel JH, Tibble RW, Gross JD. PMID: 31690658; PMCID: PMC6876151.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. HP1 reshapes nucleosome core to promote phase separation of heterochromatin. Nature. 2019 11; 575(7782):390-394. Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Narlikar GJ. PMID: 31618757; PMCID: PMC7039410.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    17. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host Microbe. 2019 07 10; 26(1):86-99.e7. Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ. PMID: 31253590; PMCID: PMC7153695.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    18. Conformational Dynamics of the HIV-Vif Protein Complex. Biophys J. 2019 04 23; 116(8):1432-1445. Ball KA, Chan LM, Stanley DJ, Tierney E, Thapa S, Ta HM, Burton L, Binning JM, Jacobson MP, Gross JD. PMID: 30961890; PMCID: PMC6486493.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay. Nat Struct Mol Biol. 2018 12; 25(12):1077-1085. Mugridge JS, Coller J, Gross JD. PMID: 30518847.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    20. Decapping enzymes STOP "cancer" ribosomes in their tracks. EMBO J. 2018 12 03; 37(23). Mugridge JS, Gross JD. PMID: 30455174; PMCID: PMC6276877.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability. Cell Host Microbe. 2018 10 10; 24(4):542-557.e9. Nayak A, Kim DY, Trnka MJ, Kerr CH, Lidsky PV, Stanley DJ, Rivera BM, Li KH, Burlingame AL, Jan E, Frydman J, Gross JD, Andino R. PMID: 30308158; PMCID: PMC6450077.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18). Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453; PMCID: PMC6138441.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    23. Control of mRNA decapping by autoinhibition. Nucleic Acids Res. 2018 07 06; 46(12):6318-6329. Paquette DR, Tibble RW, Daifuku TS, Gross JD. PMID: 29618050; PMCID: PMC6158755.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    24. Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nat Commun. 2018 03 20; 9(1):1152. Mugridge JS, Tibble RW, Ziemniak M, Jemielity J, Gross JD. PMID: 29559651; PMCID: PMC5861098.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    25. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 01; 14(1):e1006830. Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. PMID: 29304101; PMCID: PMC5773222.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Application of a Schizosaccharomyces pombe Edc1-fused Dcp1-Dcp2 decapping enzyme for transcription start site mapping. RNA. 2018; 24(2):251-257. DR Paquette, JS Mugridge, DE Weinberg, and JD Gross. .
    27. Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription. Annu Rev Virol. 2017 09 29; 4(1):241-260. Faust TB, Binning JM, Gross JD, Frankel AD. PMID: 28961413; PMCID: PMC5750048.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    28. Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2. J Mol Biol. 2017 11 24; 429(23):3666-3677. Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ. PMID: 28942089; PMCID: PMC5693750.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    29. Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler. Science. 2017 01 20; 355(6322). Sinha KK, Gross JD, Narlikar GJ. PMID: 28104838; PMCID: PMC5656449.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    30. CBFß and HIV Infection. Adv Exp Med Biol. 2017; 962:415-431. Kim DY, Gross JD. PMID: 28299671.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    31. Molecular biology: Messenger RNAs marked for longer life. Nature. 2017 01 19; 541(7637):293-294. Weinberg DE, Gross JD. PMID: 28002405.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Structural basis of mRNA-cap recognition by Dcp1-Dcp2. Nat Struct Mol Biol. 2016 Nov; 23(11):987-994. Mugridge JS, Ziemniak M, Jemielity J, Gross JD. PMID: 27694842; PMCID: PMC5113729.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    33. Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex. RNA. 2016 Apr; 22(4):518-29. Ziemniak M, Mugridge JS, Kowalska J, Rhoads RE, Gross JD, Jemielity J. PMID: 26826132; PMCID: PMC4793208.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. Thermodynamics of Rev-RNA interactions in HIV-1 Rev-RRE assembly. Biochemistry. 2015 Oct 27; 54(42):6545-54. Jayaraman B, Mavor D, Gross JD, Frankel AD. PMID: 26422686; PMCID: PMC4801481.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    35. Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity. Cell Rep. 2015 May 26; 11(8):1236-50. Kane JR, Stanley DJ, Hultquist JF, Johnson JR, Mietrach N, Binning JM, Jónsson SR, Barelier S, Newton BW, Johnson TL, Franks-Skiba KE, Li M, Brown WL, Gunnarsson HI, Adalbjornsdóttir A, Fraser JS, Harris RS, Andrésdóttir V, Gross JD, Krogan NJ. PMID: 25981045; PMCID: PMC4613747.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    36. A mutually assured destruction mechanism attenuates light signaling in Arabidopsis. Science. 2014 Jun 06; 344(6188):1160-1164. Ni W, Xu SL, Tepperman JM, Stanley DJ, Maltby DA, Gross JD, Burlingame AL, Wang ZY, Quail PH. PMID: 24904166; PMCID: PMC4414656.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    37. Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2. Structure. 2013 Sep 03; 21(9):1571-80. Aglietti RA, Floor SN, McClendon CL, Jacobson MP, Gross JD. PMID: 23911090; PMCID: PMC3769517.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    38. The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol. 2013 Jul; 20(7):876-83. Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR. PMID: 23728292; PMCID: PMC3702670.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    39. Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control. Mol Cell. 2013 Apr 11; 50(1):2-4. Mugridge JS, Gross JD. PMID: 23582258; PMCID: PMC3665275.
      View in: PubMed   Mentions:    Fields:    
    40. From systems to structure: bridging networks and mechanism. Mol Cell. 2013 Jan 24; 49(2):222-31. Fraser JS, Gross JD, Krogan NJ. PMID: 23352243; PMCID: PMC3558917.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    41. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21; 49(4):632-44. Kim DY, Kwon E, Hartley PD, Crosby DC, Mann S, Krogan NJ, Gross JD. PMID: 23333304; PMCID: PMC3582769.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    42. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS Pathog. 2012 Dec; 8(12):e1003085. Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD. PMID: 23300442; PMCID: PMC3531493.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    43. The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA. Protein Sci. 2012 Sep; 21(9):1334-43. Kwon E, Kim DY, Ngo TD, Gross CA, Gross JD, Kim KK. PMID: 22760860; PMCID: PMC3631362.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    44. In support of the BMRB. Nat Struct Mol Biol. 2012 Sep; 19(9):854-60. Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S. PMID: 22955930.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    45. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2872-7. Floor SN, Borja MS, Gross JD. PMID: 22323607; PMCID: PMC3286934.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    46. Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature. 2011 Dec 21; 481(7381):371-5. Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, Sali A, Craik CS, Harris RS, Gross JD, Krogan NJ. PMID: 22190037; PMCID: PMC3310910.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    47. Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. RNA. 2011 Feb; 17(2):278-90. Borja MS, Piotukh K, Freund C, Gross JD. PMID: 21148770; PMCID: PMC3022277.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    48. The crystal structure Escherichia coli Spy. Protein Sci. 2010 Nov; 19(11):2252-9. Kwon E, Kim DY, Gross CA, Gross JD, Kim KK. PMID: 20799348; PMCID: PMC3005795.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    49. A split active site couples cap recognition by Dcp2 to activation. Nat Struct Mol Biol. 2010 Sep; 17(9):1096-101. Floor SN, Jones BN, Hernandez GA, Gross JD. PMID: 20711189; PMCID: PMC2933276.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    50. Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila. Nat Struct Mol Biol. 2010 May; 17(5):547-54. Nayak A, Berry B, Tassetto M, Kunitomi M, Acevedo A, Deng C, Krutchinsky A, Gross J, Antoniewski C, Andino R. PMID: 20400949; PMCID: PMC3815677.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    51. Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae. Mol Cell Biol. 2010 Mar; 30(6):1446-56. Harigaya Y, Jones BN, Muhlrad D, Gross JD, Parker R. PMID: 20086104; PMCID: PMC2832485.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    52. An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model. J Mol Biol. 2009 Jun 26; 389(5):819-32. Harjes E, Gross PJ, Chen KM, Lu Y, Shindo K, Nowarski R, Gross JD, Kotler M, Harris RS, Matsuo H. PMID: 19389408; PMCID: PMC2700007.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    53. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc. 2008 Dec 03; 130(48):16168-9. Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. PMID: 18998650; PMCID: PMC2645923.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    54. Control of mRNA decapping by Dcp2: An open and shut case? RNA Biol. 2008 Oct-Dec; 5(4):189-92. Floor SN, Jones BN, Gross JD. PMID: 18971632; PMCID: PMC2699264.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    55. Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1). Mol Cell Biol. 2008 Dec; 28(24):7476-86. Campbell LA, Faivre EJ, Show MD, Ingraham JG, Flinders J, Gross JD, Ingraham HA. PMID: 18838537; PMCID: PMC2593425.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    56. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol. 2008 Sep; 15(9):916-23. Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P. PMID: 19172744; PMCID: PMC2767265.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    57. mRNA decapping is promoted by an RNA-binding channel in Dcp2. Mol Cell. 2008 Feb 15; 29(3):324-36. Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD. PMID: 18280238.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    58. A kinetic assay to monitor RNA decapping under single- turnover conditions. Methods Enzymol. 2008; 448:23-40. Jones BN, Quang-Dang DU, Oku Y, Gross JD. PMID: 19111169.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    59. The structural basis of yeast prion strain variants. Nature. 2007 Sep 13; 449(7159):233-7. Toyama BH, Kelly MJ, Gross JD, Weissman JS. PMID: 17767153.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    60. Backbone and sidechain methyl Ile (delta1), Leu and Val resonance assignments of the catalytic domain of the yeast mRNA decapping enzyme, Dcp2. Biomol NMR Assign. 2007 Jul; 1(1):17-8. Deshmukh MV, Oku Y, Gross JD. PMID: 19636815.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    61. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. PMID: 17254965.
      View in: PubMed   Mentions: 289     Fields:    Translation:HumansAnimalsCells
    62. Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. J Mol Biol. 2006 Mar 03; 356(4):982-92. von der Haar T, Oku Y, Ptushkina M, Moerke N, Wagner G, Gross JD, McCarthy JE. PMID: 16405910.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    63. A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol Cell. 2005 Oct 07; 20(1):117-29. He C, Hus JC, Sun LJ, Zhou P, Norman DP, Dötsch V, Wei H, Gross JD, Lane WS, Wagner G, Verdine GL. PMID: 16209950.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    64. NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath). Biochemistry. 2004 Sep 28; 43(38):11983-91. Chatwood LL, Müller J, Gross JD, Wagner G, Lippard SJ. PMID: 15379538.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    65. The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. Nat Struct Mol Biol. 2004 Jun; 11(6):503-11. von der Haar T, Gross JD, Wagner G, McCarthy JE. PMID: 15164008.
      View in: PubMed   Mentions: 109     Fields:    Translation:Cells
    66. Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell. 2003 Dec 12; 115(6):739-50. Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G. PMID: 14675538.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    67. Broadband 13C-13C adiabatic mixing in solution optimized for high fields. J Magn Reson. 2003 Nov; 165(1):59-79. Bennett AE, Gross JD, Wagner G. PMID: 14568517.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    68. A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes. J Biomol NMR. 2003 Mar; 25(3):235-42. Gross JD, Gelev VM, Wagner G. PMID: 12652135.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    69. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc. 2002 Feb 20; 124(7):1234-40. Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. PMID: 11841292.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    70. Global Fold Determination of large proteins using site-directed spin labeling. Protein NMR for the Millenium. 2002; 79-101. JL Battiste, JD Gross, and G Wagner.
    71. Interactions of the eukaryotic translation initiation factor eIF4E. Cold Spring Harb Symp Quant Biol. 2001; 66:397-402. Gross JD, Matsuo H, Fletcher M, Sachs AB, Wagner G. PMID: 12762042.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    72. The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1. J Biol Chem. 1999 Jul 23; 274(30):21297-304. Hershey PE, McWhirter SM, Gross JD, Wagner G, Alber T, Sachs AB. PMID: 10409688.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    73. Determination of the peptide torsion angle phi by 15N chemical shift and 13Calpha-1Halpha dipolar tensor correlation in solid-state MAS NMR. J Magn Reson. 1998 Nov; 135(1):169-77. Hong M, Gross JD, Hu W, Griffin RG. PMID: 9799691.
      View in: PubMed   Mentions: 14     Fields:    
    74. Effects of membrane peptide dynamics on high-resolution magic-angle spinning NMR. Journal de Chimie Physique et de Physico-Chimie Biologique. 1998; 95(2):460-466. DE Warschawski, JD Gross, and RG Griffin.
    75. Tilted n-fold symmetric radio frequency pulse sequences: Applications to CSA and heteronuclear dipolar recoupling in homonuclear dipolar coupled spin networks. The Journal of Chemical Physics. 1998; 108(17):7286-7293. JD Gross, PR Costa, and RG Griffin.
    76. Coupling amplification in 2D MAS NMR and its application to torsion angle determination in peptides. J Magn Reson. 1997 Nov; 129(1):85-92. Hong M, Gross JD, Rienstra CM, Griffin RG, Kumashiro KK, Schmidt-Rohr K. PMID: 9405219.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    77. Solid-state NMR measurement of psi in peptides: a NCCN 2Q-heteronuclear local field experiment. Chemical Physics Letters. 1997; 280(1-2):95-103. PR Costa, JD Gross, M Hong, and RG Griffin.
    78. Site-Resolved Determination of Peptide Torsion Angle phi from the relative orientation of backbone NH and CH bonds by solid-state NMR. The Journal of Physical Chemistry B. 1997; 101(30):5869-5874. M Hong, JD Gross, and RG Griffin.
    79. Dipolar recoupling in MAS NMR: a probe for segmental order in lipid bilayers. Journal of the American Chemical Society. 1997; 119(4):796-802. JD Gross, DE Warschawski, and RG Griffin.
    80. Multidimensional NMR in lipid systems. Coherence transfer through J couplings under MAS. Journal of Magnetic Resonance Series B. 1995; 106:190. JD Gross, PR Costa, JP Dubacq, DE Warschawski, PN Lirsac, PF Devaux, and RG Griffin.
    81. Structural studies of a family of high affinity ligands for GPIIb/IIIa. Journal of the American Chemical Society. 1994; 116(8):3207-3219. AC Bach, CJ Eyermann, JD Gross, MJ Bower, RL Harlow, PC Weber, WF DeGrado.
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