Hiten Madhani, MD, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
AddressLocation Required, #001
Phone415-514-1143
ORCID ORCID Icon0000-0001-7400-6657 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San FranciscoMD06/1995Medicine
    UCSF, San FranciscoPhD12/1993Genetics
    Stanford, Stanford, CABS06/1986Biological Sciences
    Collapse Awards and Honors
    UCSF2020Fellow of the American Association for the Advancement of Science (AAAS)
    UCSF2014Fellow of the American Academy of Microbiology
    UCSF (Graduate Division)2015Outstanding Faculty Mentor Award
    UCSF2005  - 2010Lymphoma and Leukemia Society Scholar Award
    UCSF2000  - 2005David and Lucille Packard Foundation Fellowship
    UCSF1999  - 2002Burroughs-Wellcome Career Award
    Whitehead Institute1995  - 1999Helen Hay Whitney Postdoctoral Research Fellowship
    UCSF1987Dean's Prize for Student Research
    Stanford University1986Fox Award for Outstanding Undergraduate in Biology
    Stanford University1986Firestone Medal

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Intracellular Recognition of Fungi by the Innate Immune System
    NIH R21AI150083Jan 22, 2020 - Dec 31, 2021
    Role: Principal Investigator
    Peptide-based signaling and virulence in Cryptococcus neoformans
    NIH R56AI126726May 1, 2017 - Apr 30, 2019
    Role: Principal Investigator
    Epigenetic control of virulence in a fungal meningitis pathogen
    NIH R01AI120464Jul 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Cryptococcus knockout and tag resource
    NIH R01AI100272May 1, 2012 - May 31, 2022
    Role: Principal Investigator
    Chemical-genetic functional annotation of the genome of a meningitis pathogen
    NIH R01AI099206Apr 1, 2012 - Mar 31, 2018
    Role: Principal Investigator
    Regulation of Virulence of Cryptococcus neoformans
    NIH R01AI096869Nov 4, 2011 - Oct 31, 2016
    Role: Principal Investigator
    Systems Biology of Molecular Noise in Yeast
    NIH R01GM086379May 1, 2009 - Jun 28, 2013
    Role: Co-Principal Investigator
    Systematic Genetic Analysis of Fungal Virulence
    NIH R01AI065519Jul 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    Mechanisms of Gene Silencing
    NIH R01GM071801Apr 1, 2005 - Dec 31, 2022
    Role: Principal Investigator
    Mechanisms of Signal Transduction Specificity in Yeast
    NIH R01GM063670Jun 1, 2001 - Feb 28, 2011
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abstract 2289 Understanding the dynamic design of the human spliceosome. Journal of Biological Chemistry. 2024 Mar 1; 300(3):106661. Madhani MH. .
      View in: Publisher Site   Mentions:
    2. Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens. Trends Microbiol. 2023 Nov 18. Boucher MJ, Madhani HD. PMID: 37985333.
      View in: PubMed   Mentions:    Fields:    
    3. Meet the authors: Irene Beusch and Hiten Madhani. Mol Cell. 2023 07 20; 83(14):2387-2389. Beusch I, Madhani H. PMID: 37478821.
      View in: PubMed   Mentions:    Fields:    
    4. Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles. Mol Cell. 2023 07 20; 83(14):2578-2594.e9. Beusch I, Rao B, Studer MK, Luhovska T, Šukyte V, Lei S, Oses-Prieto J, SeGraves E, Burlingame A, Jonas S, Madhani HD. PMID: 37402368; PMCID: PMC10484158.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system. Immunity. 2023 07 11; 56(7):1548-1560.e5. De Giovanni M, Dang EV, Chen KY, An J, Madhani HD, Cyster JG. PMID: 37279752; PMCID: PMC10360074.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity. Nat Struct Mol Biol. 2023 07; 30(7):891-901. Lee S, Abini-Agbomson S, Perry DS, Goodman A, Rao B, Huang MY, Diedrich JK, Moresco JJ, Yates JR, Armache KJ, Madhani HD. PMID: 37217653.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response. Cell Host Microbe. 2022 11 09; 30(11):1589-1601.e5. Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM. PMID: 36323314; PMCID: PMC9744107.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Christine Guthrie (1945-2022): a tribute from her trainees. RNA. 2022 Sep 30. Mayerle M, Madhani HD, Maeder C. PMID: 36180247; PMCID: PMC9670807.
      View in: PubMed   Mentions:    Fields:    
    9. Christine Guthrie (1945–2022). Cell. 2022 Sep 1; 185(20):3639-3642. Brow BD, Madhani MH. .
      View in: Publisher Site   Mentions:
    10. Telomere transposon takeover in Cryptococcus. Nat Microbiol. 2022 08; 7(8):1108-1109. Huang MY, Madhani HD. PMID: 35918419.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Secreted fungal virulence effector triggers allergic inflammation via TLR4. Nature. 2022 08; 608(7921):161-167. Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD. PMID: 35896747; PMCID: PMC9744105.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    12. Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol Cell. 2022 03 17; 82(6):1186-1198.e6. Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ. PMID: 35202575; PMCID: PMC8956514.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    13. Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging. Genetics. 2022 01 04; 220(1). Huang MY, Joshi MB, Boucher MJ, Lee S, Loza LC, Gaylord EA, Doering TL, Madhani HD. PMID: 34791226; PMCID: PMC8733451.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    14. Model organism databases are in jeopardy. Development. 2021 10 01; 148(19). Bellen HJ, Hubbard EJA, Lehmann R, Madhani HD, Solnica-Krezel L, Southard-Smith EM. PMID: 35231122; PMCID: PMC10656462.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    15. Coupling of spliceosome complexity to intron diversity. Curr Biol. 2021 11 22; 31(22):4898-4910.e4. Sales-Lee J, Perry DS, Bowser BA, Diedrich JK, Rao B, Beusch I, Yates JR, Roy SW, Madhani HD. PMID: 34555349; PMCID: PMC8967684.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. J Med Chem. 2021 05 27; 64(10):6706-6719. Kryštufek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drag M, Majer P, Hájek M, Rezácová P, Madhani HD, Craik CS, Konvalinka J. PMID: 34006103; PMCID: PMC8165695.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Unbelievable but True: Epigenetics and Chromatin in Fungi. Trends Genet. 2021 01; 37(1):12-20. Madhani HD. PMID: 33092902; PMCID: PMC8994648.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans. PLoS Genet. 2020 09; 16(9):e1008744. Summers DK, Perry DS, Rao B, Madhani HD. PMID: 32956370; PMCID: PMC7537855.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Cholesterol in quarantine. Nat Immunol. 2020 07; 21(7):716-717. Dang EV, Madhani HD, Vance RE. PMID: 32514065.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    20. ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA. Mol Cell. 2020 07 02; 79(1):127-139.e4. Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD. PMID: 32437639; PMCID: PMC7335330.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom. Nucleic Acids Res. 2020 03 18; 48(5):2312-2331. Wallace EWJ, Maufrais C, Sales-Lee J, Tuck LR, de Oliveira L, Feuerbach F, Moyrand F, Natarajan P, Madhani HD, Janbon G. PMID: 32020195; PMCID: PMC7049704.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    22. Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase. Cell. 2020 Feb 20; 180(4):816. Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cooke S, Shea T, Gienger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD. PMID: 32084344; PMCID: PMC7201975.
      View in: PubMed   Mentions: 5     Fields:    
    23. Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase. Cell. 2020 01 23; 180(2):263-277.e20. Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cook S, Shea T, Geinger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD. PMID: 31955845; PMCID: PMC7197499.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    24. A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans. G3 (Bethesda). 2019 07 09; 9(7):2235-2244. Burke JE, Longhurst AD, Natarajan P, Rao B, Liu J, Sales-Lee J, Mortensen Y, Moresco JJ, Diedrich JK, Yates JR, Madhani HD. PMID: 31092606; PMCID: PMC6643885.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. PLoS Biol. 2019 06; 17(6):e3000331. Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. PMID: 31226107; PMCID: PMC6613695.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control. Cell. 2018 10 18; 175(3):877-886.e10. Harrigan P, Madhani HD, El-Samad H. PMID: 30340045; PMCID: PMC6258208.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    27. Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biol Open. 2018 Jul 23; 7(7). Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. PMID: 30037883; PMCID: PMC6078352.
      View in: PubMed   Mentions: 12     Fields:    
    28. Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly. Genes Dev. 2018 07 01; 32(13-14):953-964. Parsa JY, Boudoukha S, Burke J, Homer C, Madhani HD. PMID: 29967291; PMCID: PMC6075038.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution. Cell. 2018 05 03; 173(4):1014-1030.e17. Burke JE, Longhurst AD, Merkurjev D, Sales-Lee J, Rao B, Moresco JJ, Yates JR, Li JJ, Madhani HD. PMID: 29727661; PMCID: PMC5940017.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    30. Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. Mol Microbiol. 2018 06; 108(5):473-494. Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ. PMID: 29608794; PMCID: PMC5980777.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Total RNA Isolation and Quantification of Specific RNAs in Fission Yeast. Methods Mol Biol. 2018; 1721:63-72. Roth R, Madhani HD, Garcia JF. PMID: 29423847; PMCID: PMC6821438.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    32. Ten principles of heterochromatin formation and function. Nat Rev Mol Cell Biol. 2018 04; 19(4):229-244. Allshire RC, Madhani HD. PMID: 29235574; PMCID: PMC6822695.
      View in: PubMed   Mentions: 292     Fields:    Translation:HumansAnimalsCells
    33. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLoS Pathog. 2016 Dec; 12(12):e1006051. Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. PMID: 27977806; PMCID: PMC5158083.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    34. Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics. PLoS One. 2016; 11(8):e0159292. Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD. PMID: 27479698; PMCID: PMC4968791.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast. Nucleic Acids Res. 2016 Nov 02; 44(19):9180-9189. Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA. PMID: 27402158; PMCID: PMC5100562.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Intracellular Action of a Secreted Peptide Required for Fungal Virulence. Cell Host Microbe. 2016 Jun 08; 19(6):849-64. Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik CS, Madhani HD. PMID: 27212659; PMCID: PMC5186401.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    37. Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Res. 2015 Oct 15; 43(18):9017-27. Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR, Madhani HD. PMID: 26275773; PMCID: PMC4605306.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    38. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nat Commun. 2015 May 13; 6:7121. Desjardins CA, Sanscrainte ND, Goldberg JM, Heiman D, Young S, Zeng Q, Madhani HD, Becnel JJ, Cuomo CA. PMID: 25968466; PMCID: PMC4435813.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    39. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. G3 (Bethesda). 2015 May 08; 5(7):1453-61. Garcia JF, Al-Sady B, Madhani HD. PMID: 25957277; PMCID: PMC4502379.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    40. Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell. 2015 Jan 15; 160(1-2):204-18. Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD. PMID: 25533783; PMCID: PMC4303595.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    41. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 2014 Nov 20; 159(5):1168-1187. Brown JCS, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. PMID: 25416953; PMCID: PMC4243055.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    42. Functional profiling of human fungal pathogen genomes. Cold Spring Harb Perspect Med. 2014 Nov 06; 5(3):a019596. Goranov AI, Madhani HD. PMID: 25377143; PMCID: PMC4355250.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    43. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. mBio. 2014 Feb 11; 5(1):e00765-13. Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. PMID: 24520056; PMCID: PMC3950514.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    44. Using a Transcriptional Network to Approach the Mechanism of Fungal Meningitis. Biophysical Journal. 2014 Jan 1; 106(2):374a. Homer HC, Goranov GA, Santos SD, Caradonna CI, Petnic PS, Madhani MH. .
      View in: Publisher Site   Mentions:
    45. snRNA catalysts in the spliceosome's ancient core. Cell. 2013 Dec 05; 155(6):1213-5. Madhani HD. PMID: 24315092; PMCID: PMC4162089.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Recognizing the enemy within: licensing RNA-guided genome defense. Trends Biochem Sci. 2014 Jan; 39(1):25-34. Dumesic PA, Madhani HD. PMID: 24280023; PMCID: PMC3902128.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    47. The frustrated gene: origins of eukaryotic gene expression. Cell. 2013 Nov 07; 155(4):744-9. Madhani HD. PMID: 24209615; PMCID: PMC4163148.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    48. The spliceosome as a transposon sensor. RNA Biol. 2013 Nov; 10(11):1653-60. Dumesic PA, Madhani HD. PMID: 24418889; PMCID: PMC3907475.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    49. A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism. Genes Dev. 2013 Sep 01; 27(17):1851-6. Marina DB, Shankar S, Natarajan P, Finn KJ, Madhani HD. PMID: 24013500; PMCID: PMC3778239.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    50. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91. Al-Sady B, Madhani HD, Narlikar GJ. PMID: 23849629; PMCID: PMC3752401.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    51. Abstract IA23: Functional and structural studies of HP1 heterochromatin. DNA Methylation. 2013 Jul 1; ia23-ia23. Canzio CD, Liang LM, Naber NN, Larson LA, Marina MD, Garcia GJ, Madhani MH, Cooke CR, Schuck SP, Cheng CY, Narlikar NG. .
      View in: Publisher Site   Mentions:
    52. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. PMID: 23485968; PMCID: PMC3907283.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    53. Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell. 2013 Feb 28; 152(5):957-68. Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD. PMID: 23415457; PMCID: PMC3645481.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    54. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet. 2012; 8(12):e1003168. Brown JC, Madhani HD. PMID: 23300468; PMCID: PMC3531484.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    55. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. EMBO Reports. 2012 Nov 13; 13(12):1152-1152. Braun BS, Madhani MH. .
      View in: Publisher Site   Mentions:
    56. Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell. 2012 Nov 13; 23(5):1059-71. Xu M, Soloveychik M, Ranger M, Schertzberg M, Shah Z, Raisner R, Venkatasubrahmanyan S, Tsui K, Gebbia M, Hughes T, van Bakel H, Nislow C, Madhani HD, Meneghini MD. PMID: 23123093; PMCID: PMC3806484.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    57. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. EMBO Rep. 2012 Jun 29; 13(7):619-30. Braun S, Madhani HD. PMID: 22688965; PMCID: PMC3388787.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    58. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63. Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. PMID: 22733737; PMCID: PMC3396509.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    59. Quorum sensing in fungi: Q&A. PLoS Pathog. 2011 Oct; 7(10):e1002301. Madhani HD. PMID: 22046125; PMCID: PMC3203159.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    60. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol. 2011 Oct; 31(20):4193-204. Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bähler J, Winston F. PMID: 21844224; PMCID: PMC3187285.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    61. Can a systems perspective help us appreciate the biological meaning of small effects? Dev Cell. 2011 Jul 19; 21(1):11-3. El-Samad H, Madhani HD. PMID: 21763599; PMCID: PMC3615985.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    62. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10620-5. Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. PMID: 21673141; PMCID: PMC3127919.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    63. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe. 2011 Mar 17; 9(3):243-251. Chun CD, Brown JCS, Madhani HD. PMID: 21402362; PMCID: PMC3077425.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    64. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 2011 Jan 07; 144(1):41-54. Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD. PMID: 21215368; PMCID: PMC3645473.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    65. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 07; 41(1):67-81. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. PMID: 21211724; PMCID: PMC3752404.
      View in: PubMed   Mentions: 166     Fields:    Translation:Cells
    66. Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat Cell Biol. 2010 Oct; 12(10):954-62. McCullagh E, Seshan A, El-Samad H, Madhani HD. PMID: 20852627; PMCID: PMC2948760.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    67. Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans. PLoS One. 2010 Sep 02; 5(9). Chun CD, Madhani HD. PMID: 20824073; PMCID: PMC2932688.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    68. Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions. Genes Dev. 2010 Aug 15; 24(16):1758-71. Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD. PMID: 20675407; PMCID: PMC2922504.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    69. Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans. Methods Enzymol. 2010; 470:797-831. Chun CD, Madhani HD. PMID: 20946836; PMCID: PMC3611884.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    70. Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo. Eukaryot Cell. 2010 Jan; 9(1):31-6. Bao MZ, Shock TR, Madhani HD. PMID: 19897738; PMCID: PMC2805291.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    71. Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. PLoS Genet. 2009 Aug; 5(8):e1000588. Hwang WW, Madhani HD. PMID: 19662160; PMCID: PMC2716543.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    72. “Pearls”: A New Type of Open-Access Educational Resource. PLoS Pathogens. 2009 Jun 26; 5(6):e1000499. Madhani MH, Haldar HK, McFadden MG. .
      View in: Publisher Site   Mentions:
    73. Mechanisms that specify promoter nucleosome location and identity. Cell. 2009 May 01; 137(3):445-58. Hartley PD, Madhani HD. PMID: 19410542; PMCID: PMC2677553.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    74. Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity. Eukaryot Cell. 2009 Apr; 8(4):606-16. Shock TR, Thompson J, Yates JR, Madhani HD. PMID: 19218425; PMCID: PMC2669196.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    75. Epigenomics: a roadmap, but to where? Science. 2008 Oct 03; 322(5898):43-4. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. PMID: 18832628; PMCID: PMC4479142.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    76. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell. 2008 Oct 03; 135(1):174-88. Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. PMID: 18854164; PMCID: PMC2628477.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimals
    77. Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism. Genetics. 2008 Aug; 179(4):1933-44. Raisner RM, Madhani HD. PMID: 18689887; PMCID: PMC2516070.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    78. Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe. J Biol Chem. 2008 Sep 19; 283(38):25770-3. Rougemaille M, Shankar S, Braun S, Rowley M, Madhani HD. PMID: 18658154; PMCID: PMC2533792.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    79. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods. 2008 Aug; 5(8):711-8. Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. PMID: 18622397; PMCID: PMC2756093.
      View in: PubMed   Mentions: 297     Fields:    Translation:Animals
    80. Histone Variant H2A.Z Marks the 5' Ends of Both Active and Inactive Genes in Euchromatin. Cell. 2008 Jul 1; 134(1):188. Raisner RR, Hartley HP, Meneghini MM, Bao BM, Liu LC, Schreiber SS, Rando RO, Madhani MH. .
      View in: Publisher Site   Mentions:
    81. Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16609-14. Venkatasubrahmanyam S, Hwang WW, Meneghini MD, Tong AH, Madhani HD. PMID: 17925448; PMCID: PMC2034229.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    82. Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature. Curr Genet. 2007 Sep; 52(3-4):137-48. Chow ED, Liu OW, O'Brien S, Madhani HD. PMID: 17661046.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    83. Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry. Anal Chem. 2007 Jun 15; 79(12):4666-73. Cantin GT, Shock TR, Park SK, Madhani HD, Yates JR. PMID: 17523591; PMCID: PMC2535607.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    84. Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast Cryptococcus neoformans. Eukaryot Cell. 2007 Apr; 6(4):630-40. Liu OW, Kelly MJ, Chow ED, Madhani HD. PMID: 17337638; PMCID: PMC1865648.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    85. A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans. PLoS Pathog. 2007 Feb; 3(2):e22. Chun CD, Liu OW, Madhani HD. PMID: 17319742; PMCID: PMC1803011.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    86. Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics. 2007 Feb; 175(2):585-93. Tompa R, Madhani HD. PMID: 17179083; PMCID: PMC1800606.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    87. Functional analysis of protein kinase networks in living cells: beyond "knock-outs" and "knock-downs". Methods. 2006 Nov; 40(3):251-4. Madhani HD. PMID: 16884918.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    88. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr; 13(4):399-407. Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM. PMID: 16632252; PMCID: PMC2932700.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    89. H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. The FASEB Journal. 2006 Mar 1; 20(4):a466-a466. Madhani MH. .
      View in: Publisher Site   Mentions:
    90. Patterning chromatin: form and function for H2A.Z variant nucleosomes. Curr Opin Genet Dev. 2006 Apr; 16(2):119-24. Raisner RM, Madhani HD. PMID: 16503125.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    91. Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Curr Genet. 2006 Jun; 49(6):351-63. Schwartz MA, Madhani HD. PMID: 16463042.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    92. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell. 2005 Oct 21; 123(2):233-48. Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. PMID: 16239142; PMCID: PMC2039754.
      View in: PubMed   Mentions: 370     Fields:    Translation:AnimalsCells
    93. Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3587-92. Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat KM. PMID: 15738404; PMCID: PMC552777.
      View in: PubMed   Mentions: 18     Fields:    
    94. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell. 2004 Dec 29; 119(7):991-1000. Bao MZ, Schwartz MA, Cantin GT, Yates JR, Madhani HD. PMID: 15620357.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    95. A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. PLoS Biol. 2004 May; 2(5):E131. Kobor MS, Venkatasubrahmanyam S, Meneghini MD, Gin JW, Jennings JL, Link AJ, Madhani HD, Rine J. PMID: 15045029; PMCID: PMC374244.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    96. Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae. Annu Rev Genet. 2004; 38:725-48. Schwartz MA, Madhani HD. PMID: 15568991.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    97. Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell. 2003 Mar 07; 112(5):725-36. Meneghini MD, Wu M, Madhani HD. PMID: 12628191.
      View in: PubMed   Mentions: 295     Fields:    Translation:AnimalsCells
    98. A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell. 2003 Jan; 11(1):261-6. Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, Tong A, Boone C, Madhani HD. PMID: 12535538.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimalsCells
    99. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol. 2002 Aug; 4(8):574-82. Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS. PMID: 12134158.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansAnimalsCells
    100. Accounting for specificity in receptor tyrosine kinase signaling. Cell. 2001 Jul 13; 106(1):9-11. Madhani HD. PMID: 11461696.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    101. Interplay of intrinsic and extrinsic signals in yeast differentiation. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13461-3. Madhani HD. PMID: 11095703; PMCID: PMC34079.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    102. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12530-5. Madhani HD, Galitski T, Lander ES, Fink GR. PMID: 10535956; PMCID: PMC22972.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    103. Fungi take shape Fungal Morphogenesis, by David Moore. Trends in Cell Biology. 1999 Sep 1; 9(9):374. Robertson RL, Madhani MH. .
      View in: Publisher Site   Mentions:
    104. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J. 1999 Mar 01; 18(5):1257-69. Rupp S, Summers E, Lo HJ, Madhani H, Fink G. PMID: 10064592; PMCID: PMC1171216.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    105. The control of filamentous differentiation and virulence in fungi. Trends Cell Biol. 1998 Sep; 8(9):348-53. Madhani HD, Fink GR. PMID: 9728395.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    106. The riddle of MAP kinase signaling specificity. Trends Genet. 1998 Apr; 14(4):151-5. Madhani HD, Fink GR. PMID: 9594663.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    107. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell. 1997 Nov 28; 91(5):673-84. Madhani HD, Styles CA, Fink GR. PMID: 9393860.
      View in: PubMed   Mentions: 197     Fields:    Translation:AnimalsCells
    108. Genetic abnormalities in Friedreich's ataxia. N Engl J Med. 1997 Apr 03; 336(14):1022; author reply 1022-3. Madhani HD. PMID: 9091787.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    109. Combinatorial control required for the specificity of yeast MAPK signaling. Science. 1997 Feb 28; 275(5304):1314-7. Madhani HD, Fink GR. PMID: 9036858.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    110. Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics. 1994 Jul; 137(3):677-87. Madhani HD, Guthrie C. PMID: 8088513; PMCID: PMC1206027.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    111. Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome. Genes Dev. 1994 May 01; 8(9):1071-86. Madhani HD, Guthrie C. PMID: 7926788.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    112. Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet. 1994; 28:1-26. Madhani HD, Guthrie C. PMID: 7534458.
      View in: PubMed   Mentions: 163     Fields:    Translation:Cells
    113. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell. 1992 Nov 27; 71(5):803-17. Madhani HD, Guthrie C. PMID: 1423631.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    114. Multiple roles for U6 snRNA in the splicing pathway. Genes Dev. 1990 Dec; 4(12B):2264-77. Madhani HD, Bordonné R, Guthrie C. PMID: 2149118.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    115. Greetings from the RNA world. RNA Processing sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, May 16-20, 1990. New Biol. 1990 Aug; 2(8):684-7. Guthrie C, Madhani HD. PMID: 1704252.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    116. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell. 1988 Nov 04; 55(3):447-58. Jacks T, Madhani HD, Masiarz FR, Varmus HE. PMID: 2846182; PMCID: PMC7133365.
      View in: PubMed   Mentions: 320     Fields:    Translation:Cells
    117. Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Cell. 1986 May 09; 45(3):417-23. Madhani HD, Bohr VA, Hanawalt PC. PMID: 3698104.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    118. alpha DNA in African green monkey cells is organized into extremely long tandem arrays. J Biol Chem. 1986 Feb 15; 261(5):2314-8. Madhani HD, Leadon SA, Smith CA, Hanawalt PC. PMID: 3003109.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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