Frederick Chang, PhD, MD

InstitutionUniversity of California San Francisco
DepartmentCell and Tissue Biology
Address513 Parnassus Ave
San Francisco CA 94143
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    Princeton UniversityAB1984Biology
    UCSFMD PhD1992Biochemistry/Biophysics
    Oxford UniversityPostdoc1994
    UC BerkeleyPostdoc1996Molecular Cellular Biology

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    The Chang Lab studies fundamental questions concerning spatial organization within a single cell: How are cell shape and size determined? How do cells sense their own size, or their shape? How do molecular dynamics and cell mechanics contribute to determine the growth, size and shape of cells? To address these questions, we study primarily the fission yeast Schizosaccharomyces pombe. These are rod-shaped eukaryotic cells that display a highly uniform size and morphology. Many of our studies use live cell imaging and image analyses to develop quantitative models. Current projects include: regulation of cell size and growth, cytoplasmic density and turgor pressure, cell wall assembly, cytokinesis, and microtubule regulation. We use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, engineers and modelers.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chang F. Forces that shape fission yeast cells. Mol Biol Cell. 2017 Jul 07; 28(14):1819-1824. PMID: 28684607.
      View in: PubMed
    2. Atilgan E, Magidson V, Khodjakov A, Chang F. Morphogenesis of the Fission Yeast Cell through Cell Wall Expansion. Curr Biol. 2015 Aug 17; 25(16):2150-7. PMID: 26212881; PMCID: PMC4627367.
    3. Haupt A, Campetelli A, Bonazzi D, Piel M, Chang F, Minc N. Electrochemical regulation of budding yeast polarity. PLoS Biol. 2014 Dec; 12(12):e1002029. PMID: 25548923; PMCID: PMC4280105.
    4. Zhou Z, Munteanu EL, He J, Ursell T, Bathe M, Huang KC, Chang F. The contractile ring coordinates curvature-dependent septum assembly during fission yeast cytokinesis. Mol Biol Cell. 2015 Jan 01; 26(1):78-90. PMID: 25355954; PMCID: PMC4279231.
    5. Chang F, Huang KC. How and why cells grow as rods. BMC Biol. 2014 Aug 02; 12:54. PMID: 25185019; PMCID: PMC4243964.
    6. Chang F, Minc N. Electrochemical control of cell and tissue polarity. Annu Rev Cell Dev Biol. 2014; 30:317-36. PMID: 25062359.
      View in: PubMed
    7. Pan KZ, Saunders TE, Flor-Parra I, Howard M, Chang F. Cortical regulation of cell size by a sizer cdr2p. Elife. 2014 Mar 18; 3:e02040. PMID: 24642412; PMCID: PMC3956294.
    8. Basu R, Munteanu EL, Chang F. Role of turgor pressure in endocytosis in fission yeast. Mol Biol Cell. 2014 Mar; 25(5):679-87. PMID: 24403609; PMCID: PMC3937093.
    9. Chang F, Atilgan E, Burgess D, Minc N. Manipulating cell shape by placing cells into micro-fabricated chambers. Methods Mol Biol. 2014; 1136:281-90. PMID: 24633802.
      View in: PubMed
    10. Hou H, Zhou Z, Wang Y, Wang J, Kallgren SP, Kurchuk T, Miller EA, Chang F, Jia S. Csi1 links centromeres to the nuclear envelope for centromere clustering. J Cell Biol. 2012 Nov 26; 199(5):735-44. PMID: 23166349; PMCID: PMC3514793.
    11. Atilgan E, Burgess D, Chang F. Localization of cytokinesis factors to the future cell division site by microtubule-dependent transport. Cytoskeleton (Hoboken). 2012 Nov; 69(11):973-82. PMID: 23001894; PMCID: PMC3593075.
    12. Proctor SA, Minc N, Boudaoud A, Chang F. Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast. Curr Biol. 2012 Sep 11; 22(17):1601-8. PMID: 22840513; PMCID: PMC3443309.
    13. Basu R, Chang F. Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis. Curr Biol. 2011 Jun 07; 21(11):905-16. PMID: 21620704; PMCID: PMC3121306.
    14. Minc N, Burgess D, Chang F. Influence of cell geometry on division-plane positioning. Cell. 2011 Feb 04; 144(3):414-26. PMID: 21295701; PMCID: PMC3048034.
    15. Minc N, Chang F. Electrical control of cell polarization in the fission yeast Schizosaccharomyces pombe. Curr Biol. 2010 Apr 27; 20(8):710-6. PMID: 20362451; PMCID: PMC2900468.
    16. Yonetani A, Chang F. Regulation of cytokinesis by the formin cdc12p. Curr Biol. 2010 Mar 23; 20(6):561-6. PMID: 20226666; PMCID: PMC2845737.
    17. Pan KZ, Chang F. Cell-cycle control: don't supersize me. Curr Biol. 2009 Jul 14; 19(13):R517-9. PMID: 19602414.
      View in: PubMed
    18. Chang F, Martin SG. Shaping fission yeast with microtubules. Cold Spring Harb Perspect Biol. 2009 Jul; 1(1):a001347. PMID: 20066076; PMCID: PMC2742080.
    19. Minc N, Boudaoud A, Chang F. Mechanical forces of fission yeast growth. Curr Biol. 2009 Jul 14; 19(13):1096-101. PMID: 19500986; PMCID: PMC2790036.
    20. Minc N, Bratman SV, Basu R, Chang F. Establishing new sites of polarization by microtubules. Curr Biol. 2009 Jan 27; 19(2):83-94. PMID: 19147354; PMCID: PMC2820583.
    21. Bratman SV, Chang F. Mechanisms for maintaining microtubule bundles. Trends Cell Biol. 2008 Dec; 18(12):580-6. PMID: 18951798.
      View in: PubMed
    22. Yonetani A, Lustig RJ, Moseley JB, Takeda T, Goode BL, Chang F. Regulation and targeting of the fission yeast formin cdc12p in cytokinesis. Mol Biol Cell. 2008 May; 19(5):2208-19. PMID: 18305104; PMCID: PMC2366869.
    23. Bratman SV, Chang F. Stabilization of overlapping microtubules by fission yeast CLASP. Dev Cell. 2007 Dec; 13(6):812-27. PMID: 18061564; PMCID: PMC2215317.
    24. Martin SG, Rincón SA, Basu R, Pérez P, Chang F. Regulation of the formin for3p by cdc42p and bud6p. Mol Biol Cell. 2007 Oct; 18(10):4155-67. PMID: 17699595; PMCID: PMC1995706.
    25. Basu R, Chang F. Shaping the actin cytoskeleton using microtubule tips. Curr Opin Cell Biol. 2007 Feb; 19(1):88-94. PMID: 17194581.
      View in: PubMed
    26. Padte NN, Martin SG, Howard M, Chang F. The cell-end factor pom1p inhibits mid1p in specification of the cell division plane in fission yeast. Curr Biol. 2006 Dec 19; 16(24):2480-7. PMID: 17140794.
      View in: PubMed
    27. Daga RR, Lee KG, Bratman S, Salas-Pino S, Chang F. Self-organization of microtubule bundles in anucleate fission yeast cells. Nat Cell Biol. 2006 Oct; 8(10):1108-13. PMID: 16998476.
      View in: PubMed
    28. Daga RR, Yonetani A, Chang F. Asymmetric microtubule pushing forces in nuclear centering. Curr Biol. 2006 Aug 08; 16(15):1544-50. PMID: 16890530.
      View in: PubMed
    29. Martin SG, Chang F. Dynamics of the formin for3p in actin cable assembly. Curr Biol. 2006 Jun 20; 16(12):1161-70. PMID: 16782006.
      View in: PubMed
    30. Martin SG, Chang F. New end take off: regulating cell polarity during the fission yeast cell cycle. Cell Cycle. 2005 Aug; 4(8):1046-9. PMID: 15970692.
      View in: PubMed
    31. Takeda T, Chang F. Role of fission yeast myosin I in organization of sterol-rich membrane domains. Curr Biol. 2005 Jul 26; 15(14):1331-6. PMID: 16051179.
      View in: PubMed
    32. Daga RR, Chang F. Dynamic positioning of the fission yeast cell division plane. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8228-32. PMID: 15928091; PMCID: PMC1142117.
    33. Martin SG, McDonald WH, Yates JR, Chang F. Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity. Dev Cell. 2005 Apr; 8(4):479-91. PMID: 15809031.
      View in: PubMed
    34. Zimmerman S, Chang F. Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast. Mol Biol Cell. 2005 Jun; 16(6):2719-33. PMID: 15772152; PMCID: PMC1142419.
    35. Chang F, Feierbach B, Martin S. Regulation of actin assembly by microtubules in fission yeast cell polarity. Novartis Found Symp. 2005; 269:59-66; discussion 66-72, 223-30. PMID: 16355535.
      View in: PubMed
    36. Zimmerman S, Daga RR, Chang F. Intra-nuclear microtubules and a mitotic spindle orientation checkpoint. Nat Cell Biol. 2004 Dec; 6(12):1245-6. PMID: 15573098.
      View in: PubMed
    37. Takeda T, Kawate T, Chang F. Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast. Nat Cell Biol. 2004 Nov; 6(11):1142-4. PMID: 15517003.
      View in: PubMed
    38. Feierbach B, Verde F, Chang F. Regulation of a formin complex by the microtubule plus end protein tea1p. J Cell Biol. 2004 Jun 07; 165(5):697-707. PMID: 15184402; PMCID: PMC2172381.
    39. Zimmerman S, Tran PT, Daga RR, Niwa O, Chang F. Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle. Dev Cell. 2004 Apr; 6(4):497-509. PMID: 15068790.
      View in: PubMed
    40. Chang F, Re F, Sebastian S, Sazer S, Luban J. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. Mol Biol Cell. 2004 Apr; 15(4):1793-801. PMID: 14767062; PMCID: PMC379276.
    41. Chang F, Burgess D. The contractile ring. Curr Biol. 2003 Sep 16; 13(18):R692-3. PMID: 13678603.
      View in: PubMed
    42. Martin SG, Chang F. Cell polarity: a new mod(e) of anchoring. Curr Biol. 2003 Sep 16; 13(18):R711-3. PMID: 13678610.
      View in: PubMed
    43. Chang F, Peter M. Yeasts make their mark. Nat Cell Biol. 2003 Apr; 5(4):294-9. PMID: 12669083.
      View in: PubMed
    44. Berlin A, Paoletti A, Chang F. Mid2p stabilizes septin rings during cytokinesis in fission yeast. J Cell Biol. 2003 Mar 31; 160(7):1083-92. PMID: 12654901; PMCID: PMC2172768.
    45. Pelham RJ, Chang F. Actin dynamics in the contractile ring during cytokinesis in fission yeast. Nature. 2002 Sep 05; 419(6902):82-6. PMID: 12214236.
      View in: PubMed
    46. Chang F, Peter M. Cell biology. Formins set the record straight. Science. 2002 Jul 26; 297(5581):531-2. PMID: 12142518.
      View in: PubMed
    47. Paoletti A, Chang F. Analysis of mid1p, a protein required for placement of the cell division site, reveals a link between the nucleus and the cell surface in fission yeast. Mol Biol Cell. 2000 Aug; 11(8):2757-73. PMID: 10930468; PMCID: PMC14954.
    48. Chang F, Drubin D, Nurse P. cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin. J Cell Biol. 1997 Apr 07; 137(1):169-82. PMID: 9105045; PMCID: PMC2139860.
    49. Chang F, Nurse P. How fission yeast fission in the middle. Cell. 1996 Jan 26; 84(2):191-4. PMID: 8565064.
      View in: PubMed
    50. Chang F, Woollard A, Nurse P. Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring. J Cell Sci. 1996 Jan; 109 ( Pt 1):131-42. PMID: 8834798.
      View in: PubMed
    51. Chang F, Nurse P. Finishing the cell cycle: control of mitosis and cytokinesis in fission yeast. Trends Genet. 1993 Oct; 9(10):333-5. PMID: 8273144.
      View in: PubMed
    52. Chang F, Herskowitz I. Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. Mol Biol Cell. 1992 Apr; 3(4):445-50. PMID: 1498364; PMCID: PMC275594.
    53. Herskowitz I, Ogas J, Andrews BJ, Chang F. Regulators of synthesis and activity of the G1 cyclins of budding yeast. Cold Spring Harb Symp Quant Biol. 1991; 56:33-40. PMID: 1840254.
      View in: PubMed
    54. Chang F, Herskowitz I. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell. 1990 Nov 30; 63(5):999-1011. PMID: 2147873.
      View in: PubMed
    55. Neiman AM, Chang F, Komachi K, Herskowitz I. CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Cell Regul. 1990 Apr; 1(5):391-401. PMID: 2099190; PMCID: PMC361514.
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