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    Theresa O'Brien, PhD

    TitleAssociate Chancellor
    SchoolUCSF Chancellor/EVC/FAS
    DepartmentChancellor's Immediate Off
    Address550 16th Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPh.D. Graduate Division (Biochemistry)2007
      Williams College B.A.Biology2002

      Collapse Overview 
      Collapse Overview
      Theresa O'Brien, PhD, was appointed Associate Chancellor at the University of California, San Francisco (UCSF) in September 2014, having served as Interim Assistant Chancellor for the University and Associate Dean for Research Strategy in the School of Medicine. She serves as an advisor to and designate of the Chancellor, leading key initiatives in support of UCSF’s operational and strategic priorities. O’Brien is accountable for a wide range of Chancellor Office activities related to UCSF governance structure, strategic planning, the Chancellor’s Executive Cabinet (CEC), and emergent priority issues on a day-to-day basis. In all aspects of her work, she partners closely with fellow CEC members and internal and external stakeholders to further UCSF’s mission.

      O’Brien is also an Assistant Adjunct Professor of Cellular and Molecular Pharmacology. Her research and teaching interests primarily focus on career and professional development for graduate students and postdoctoral scholars at UCSF. She directs the Graduate Student Internships for Career Exploration (GSICE) program, which provides career path education, career planning, and internship opportunities for UCSF’s basic and biomedical PhD students in fields outside of academic research. O’Brien is co-PI on a grant from the NIH to provide better resources for PhD students and postdocs to explore career options and better support faculty mentors through the Motivating INformed Decisions (MIND) program. Her other interests are around advancing precision medicine and related science policy issues.

      Theresa is a graduate of UCSF's Tetrad Graduate Program and completed her doctoral work in biochemistry under the guidance of Jim McKerrow, MD, PhD. After graduation, she worked as an Industry Contracts Officer at UCSF, negotiating industry sponsored research agreements.

      A Northern California native, she graduated Summa Cum Laude with a BA in Biology from Williams College in Williamstown, MA.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Meyers FJ, Mathur A, Fuhrmann CN, O'Brien TC, Wefes I, Labosky PA, Duncan DS, August A, Feig A, Gould KL, Friedlander MJ, Schaffer CB, Van Wart A, Chalkley R. The origin and implementation of the Broadening Experiences in Scientific Training programs: an NIH common fund initiative. FASEB J. 2016 Feb; 30(2):507-14. PMID: 26432783.
        View in: PubMed
      2. Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto KR. Precision medicine: Beyond the inflection point. Sci Transl Med. 2015 Aug 12; 7(300):300ps17. PMID: 26268311.
        View in: PubMed
      3. Mathur A, Meyers FJ, Chalkley R, O'Brien TC, Fuhrmann CN. Transforming training to reflect the workforce. Sci Transl Med. 2015 Apr 29; 7(285):285ed4. PMID: 25925677; PMCID: PMC4484856 [Available on 04/29/16].
      4. O'Brien T, Yamamoto K, Hawgood S. Commentary: Team science. Acad Med. 2013 Feb; 88(2):156-7. PMID: 23361027.
        View in: PubMed
      5. Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis. 2008; 2(9):e298. PMID: 18820745; PMCID: PMC2553486.
      6. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. PMID: 18701454; PMCID: PMC2570886.
      7. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14; 51(3):545-52. PMID: 18173229.
        View in: PubMed
      8. Au N, Kuester-Schoeck E, Mandava V, Bothwell LE, Canny SP, Chachu K, Colavito SA, Fuller SN, Groban ES, Hensley LA, O'Brien TC, Shah A, Tierney JT, Tomm LL, O'Gara TM, Goranov AI, Grossman AD, Lovett CM. Genetic composition of the Bacillus subtilis SOS system. J Bacteriol. 2005 Nov; 187(22):7655-66. PMID: 16267290; PMCID: PMC1280312.
      9. Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004 Nov 12; 279(46):48426-33. PMID: 15326171.
        View in: PubMed
      10. Wright BS, Snow JW, O'Brien TC, Lynch DV. Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. Arch Biochem Biophys. 2003 Jul 15; 415(2):184-92. PMID: 12831841.
        View in: PubMed
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