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Sam Hawgood

TitleChancellor
InstitutionUniversity of California San Francisco
DepartmentChancellor's Immediate Off
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-6582
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    Other Positions
    TitleArthur and Toni Rembe Rock Distinguished Professor


    Collapse Biography 
    Collapse Education and Training
    University of California San FranciscoFellowship1984Neonatal
    Monash University, Melbourne, AustraliaFellowship1981Neonatal
    Royal Children’s Hospital, BrisbaneResidency1980Pediatrics
    University of Queensland, Brisbane, AustraliaM.B., B.S.1975
    Collapse Awards and Honors
    American Association of Physicians2013Member
    University of Queensland2012Doctor of Medicine honoris causa
    Institute of Medicine2010Member
    UCSF Medical Center2009Exceptional Physician Award
    Oxford University, England2008Sir Peter Tizzard Memorial Lecture
    Society for Pediatric Research2005Distinguished Service Award

    Collapse Overview 
    Collapse Overview
    Sam Hawgood, MBBS, is the Chancellor and the Arthur and Toni Rembe Rock Distinguished Professor at the University of California, San Francisco (UCSF).

    Hawgood was dean of the UCSF School of Medicine and vice chancellor for medical affairs from 2009-2014, after assuming the role of interim dean in December of 2007. His distinguished career at UCSF includes serving as chair of the Department of Pediatrics and associate director of the Cardiovascular Research Institute.

    Hawgood joined UCSF as a research fellow in 1982 and was active in research until 2015. His focus on the proteins associated with pulmonary surfactant gained him an international reputation in neonatology research.

    Hawgood is a member of the American Academy of Pediatrics, the American Association of Physicians, and the National Academy of Medicine, part of the National Academy of Sciences.

    Hawgood maintained an active presence in clinical medicine for almost thirty years including serving first as division chief of the Division of Neonatology, then as chair of Pediatrics and physician-in-chief of the UCSF Benioff Children’s Hospital prior to becoming dean. He was also president of the UCSF Medical Group, the faculty association that represents more than 1,800 physicians.

    As dean of the School of Medicine, he oversaw an organization with nearly 8,000 faculty and staff, and approximately 3,655 medical and graduate students, residents, fellows, and postdoctoral scholars.

    Under his leadership, the school become the top medical school in the nation in research funding from the National Institutes of Health ($439.6 million in 2013), with many of its departments also leading the nation in their fields, reflecting the caliber of scientific research on campus. In that time, the school also became the only medical school in the nation to rank in the top five in both research and primary care education (#4 in each) in the US News & World Report’s annual assessment of graduate schools.

    The school’s clinical faculty is renowned for world-class medical care through its practice in the top-ranked UCSF Medical Center, UCSF Benioff Children’s Hospital, Langley Porter Psychiatric Institute, Zuckerberg San Francisco General Hospital and Trauma Center, and the San Francisco Veterans’ Administration Medical Center.

    As chancellor, Hawgood oversees the entire $6.7 billion UCSF enterprise, which also includes top-ranking schools of dentistry, nursing, and pharmacy, as well as a graduate division and affiliated hospitals.

    A native of Australia, Hawgood graduated medical school with First Class Honors from the University of Queensland in Brisbane. He trained in pediatrics as a resident, followed by specialization in neonatology as a fellow.


    Collapse Research 
    Collapse Research Activities and Funding
    FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell Biology
    NIH R13HL086284Aug 1, 2006 - Jul 31, 2007
    Role: Principal Investigator
    NICHD Institutional Training for Pediatricians
    NIH/NICHD T32HD044331Jun 12, 2003 - Apr 30, 2014
    Role: Principal Investigator
    Collectin Deficiency in the mouse
    NIH R01HL058047Jul 1, 1997 - Jun 30, 2006
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Principal Investigator
    Graduate Research Training in Perinatal Biology
    NIH/NICHD T32HD007162Jul 1, 1979 - Apr 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Blank R, Daniels RJ, Gilliland G, Gutmann A, Hawgood S, Hrabowski FA, Pollack ME, Price V, Reif LR, Schlissel MS. A new data effort to inform career choices in biomedicine. Science. 2017 Dec 15; 358(6369):1388-1389. PMID: 29242335.
      View in: PubMed
    2. Hu F, Ding G, Zhang Z, Gatto LA, Hawgood S, Poulain FR, Cooney RN, Wang G. Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli. Innate Immun. 2016 Jan; 22(1):9-20. PMID: 26511057.
      View in: PubMed
    3. Zhang Z, Abdel-Razek O, Hawgood S, Wang G. Protective Role of Surfactant Protein D in Ocular Staphylococcus aureus Infection. PLoS One. 2015; 10(9):e0138597. PMID: 26398197; PMCID: PMC4580580.
    4. Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto KR. Precision medicine: Beyond the inflection point. Sci Transl Med. 2015 Aug 12; 7(300):300ps17. PMID: 26268311.
      View in: PubMed
    5. Montalbano AP, Hawgood S, Mendelson CR. Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. Endocrinology. 2013 Jan; 154(1):483-98. PMID: 23183169; PMCID: PMC3529364.
    6. Stidsen JV, Khorooshi R, Rahbek MK, Kirketerp-Møller KL, Hansen PB, Bie P, Kejling K, Mandrup S, Hawgood S, Nielsen O, Nielsen CH, Owens T, Holmskov U, Sørensen GL. Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia. PLoS One. 2012; 7(4):e35066. PMID: 22509382; PMCID: PMC3324408.
    7. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug 15; 182(4):555-61. PMID: 20413632; PMCID: PMC2937245.
    8. Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Mol Immunol. 2010 Jun; 47(10):1923-30. PMID: 20413160.
      View in: PubMed
    9. Mun JJ, Tam C, Kowbel D, Hawgood S, Barnett MJ, Evans DJ, Fleiszig SM. Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model. Infect Immun. 2009 Jun; 77(6):2392-8. PMID: 19349424; PMCID: PMC2687330.
    10. Knudsen L, Wucherpfennig K, Mackay RM, Townsend P, Mühlfeld C, Richter J, Hawgood S, Reid K, Clark H, Ochs M. A recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient mice. Anat Rec (Hoboken). 2009 Feb; 292(2):183-9. PMID: 19177340.
      View in: PubMed
    11. Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY. Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L167-75. PMID: 18996902; PMCID: PMC2643990.
    12. Ni M, Tam C, Verma A, Ramphal R, Hawgood S, Evans DJ, Fleiszig SM. Expression of surfactant protein D in human corneal epithelial cells is upregulated by Pseudomonas aeruginosa. FEMS Immunol Med Microbiol. 2008 Nov; 54(2):177-84. PMID: 18657106.
      View in: PubMed
    13. Wagner AJ, Stumbaugh A, Tigue Z, Edmondson J, Paquet AC, Farmer DL, Hawgood S. Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type). Pediatr Res. 2008 Jul; 64(1):11-6. PMID: 18391847.
      View in: PubMed
    14. Jancelewicz T, Nobuhara K, Hawgood S. Laser microdissection allows detection of abnormal gene expression in cystic adenomatoid malformation of the lung. J Pediatr Surg. 2008 Jun; 43(6):1044-51. PMID: 18558180.
      View in: PubMed
    15. Knudsen L, Ochs M, Mackay R, Townsend P, Deb R, Mühlfeld C, Richter J, Gilbert F, Hawgood S, Reid K, Clark H. Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice. Respir Res. 2007 Oct 03; 8:70. PMID: 17915009; PMCID: PMC2078589.
    16. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. PMID: 17641300; PMCID: PMC2219547.
    17. Vigerust DJ, Ulett KB, Boyd KL, Madsen J, Hawgood S, McCullers JA. N-linked glycosylation attenuates H3N2 influenza viruses. J Virol. 2007 Aug; 81(16):8593-600. PMID: 17553891; PMCID: PMC1951338.
    18. Khamri W, Worku ML, Anderson AE, Walker MM, Hawgood S, Reid KB, Clark HW, Thursz MR. Helicobacter infection in the surfactant protein D-deficient mouse. Helicobacter. 2007 Apr; 12(2):112-23. PMID: 17309747.
      View in: PubMed
    19. Haque R, Umstead TM, Ponnuru P, Guo X, Hawgood S, Phelps DS, Floros J. Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice. Toxicol Appl Pharmacol. 2007 Apr 01; 220(1):72-82. PMID: 17307210; PMCID: PMC1906716.
    20. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94. PMID: 17006391.
      View in: PubMed
    21. Baldán A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA. Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis. J Biol Chem. 2006 Sep 29; 281(39):29401-10. PMID: 16887795.
      View in: PubMed
    22. Haczku A, Cao Y, Vass G, Kierstein S, Nath P, Atochina-Vasserman EN, Scanlon ST, Li L, Griswold DE, Chung KF, Poulain FR, Hawgood S, Beers MF, Crouch EC. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol. 2006 Mar 15; 176(6):3557-65. PMID: 16517724.
      View in: PubMed
    23. Giannoni E, Sawa T, Allen L, Wiener-Kronish J, Hawgood S. Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):704-10. PMID: 16456184; PMCID: PMC2644232.
    24. Sorensen GL, Madsen J, Kejling K, Tornoe I, Nielsen O, Townsend P, Poulain F, Nielsen CH, Reid KB, Hawgood S, Falk E, Holmskov U. Surfactant protein D is proatherogenic in mice. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2286-94. PMID: 16387789.
      View in: PubMed
    25. Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH. Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 2006 Jan 15; 173(2):219-25. PMID: 16210667; PMCID: PMC2662990.
    26. Jung A, Allen L, Nyengaard JR, Gundersen HJ, Richter J, Hawgood S, Ochs M. Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice. Anat Rec A Discov Mol Cell Evol Biol. 2005 Oct; 286(2):885-90. PMID: 16086431.
      View in: PubMed
    27. Casey J, Kaplan J, Atochina-Vasserman EN, Gow AJ, Kadire H, Tomer Y, Fisher JH, Hawgood S, Savani RC, Beers MF. Alveolar surfactant protein D content modulates bleomycin-induced lung injury. Am J Respir Crit Care Med. 2005 Oct 01; 172(7):869-77. PMID: 15994463; PMCID: PMC2718404.
    28. Palaniyar N, Clark H, Nadesalingam J, Shih MJ, Hawgood S, Reid KB. Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation. J Immunol. 2005 Jun 01; 174(11):7352-8. PMID: 15905582.
      View in: PubMed
    29. Ni M, Evans DJ, Hawgood S, Anders EM, Sack RA, Fleiszig SM. Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa. Infect Immun. 2005 Apr; 73(4):2147-56. PMID: 15784557; PMCID: PMC1087391.
    30. Atochina EN, Beck JM, Preston AM, Haczku A, Tomer Y, Scanlon ST, Fusaro T, Casey J, Hawgood S, Gow AJ, Beers MF. Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species. Infect Immun. 2004 Oct; 72(10):6002-11. PMID: 15385504; PMCID: PMC517574.
    31. Keller RL, Hawgood S, Neuhaus JM, Farmer DL, Lee H, Albanese CT, Harrison MR, Kitterman JA. Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia. Pediatr Res. 2004 Nov; 56(5):818-25. PMID: 15319458.
      View in: PubMed
    32. Ochs M, Knudsen L, Allen L, Stumbaugh A, Levitt S, Nyengaard JR, Hawgood S. GM-CSF mediates alveolar epithelial type II cell changes, but not emphysema-like pathology, in SP-D-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1333-41. PMID: 15310555.
      View in: PubMed
    33. Hawgood S, Brown C, Edmondson J, Stumbaugh A, Allen L, Goerke J, Clark H, Poulain F. Pulmonary collectins modulate strain-specific influenza a virus infection and host responses. J Virol. 2004 Aug; 78(16):8565-72. PMID: 15280465; PMCID: PMC479098.
    34. Hawgood S. Surfactant protein B: structure and function. Biol Neonate. 2004; 85(4):285-9. PMID: 15218284.
      View in: PubMed
    35. Atochina EN, Gow AJ, Beck JM, Haczku A, Inch A, Kadire H, Tomer Y, Davis C, Preston AM, Poulain F, Hawgood S, Beers MF. Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice. J Infect Dis. 2004 Apr 15; 189(8):1528-39. PMID: 15073692.
      View in: PubMed
    36. Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7. PMID: 14987351.
      View in: PubMed
    37. Clark H, Palaniyar N, Hawgood S, Reid KB. A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. Ann N Y Acad Sci. 2003 Dec; 1010:113-6. PMID: 15033705.
      View in: PubMed
    38. Palaniyar N, Clark H, Nadesalingam J, Hawgood S, Reid KB. Surfactant protein D binds genomic DNA and apoptotic cells, and enhances their clearance, in vivo. Ann N Y Acad Sci. 2003 Dec; 1010:471-5. PMID: 15033772.
      View in: PubMed
    39. Harrison MR, Keller RL, Hawgood S, Kitterman JA, Sandberg PL, Farmer DL, Lee H, Filly RA, Farrell JA, Albanese CT. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med. 2003 Nov 13; 349(20):1916-24. PMID: 14614166.
      View in: PubMed
    40. Brasch F, Ochs M, Kahne T, Guttentag S, Schauer-Vukasinovic V, Derrick M, Johnen G, Kapp N, Muller KM, Richter J, Giller T, Hawgood S, Buhling F. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. J Biol Chem. 2003 Dec 05; 278(49):49006-14. PMID: 13129928.
      View in: PubMed
    41. Brasch F, Johnen G, Winn-Brasch A, Guttentag SH, Schmiedl A, Kapp N, Suzuki Y, Müller KM, Richter J, Hawgood S, Ochs M. Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):449-58. PMID: 12972403.
      View in: PubMed
    42. Atochina EN, Beers MF, Hawgood S, Poulain F, Davis C, Fusaro T, Gow AJ. Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. Am J Respir Cell Mol Biol. 2004 Mar; 30(3):271-9. PMID: 12871850.
      View in: PubMed
    43. Hamrick SE, Gremmels DB, Keet CA, Leonard CH, Connell JK, Hawgood S, Piecuch RE. Neurodevelopmental outcome of infants supported with extracorporeal membrane oxygenation after cardiac surgery. Pediatrics. 2003 Jun; 111(6 Pt 1):e671-5. PMID: 12777584.
      View in: PubMed
    44. Haddad IY, Milla C, Yang S, Panoskaltsis-Mortari A, Hawgood S, Lacey DL, Blazar BR. Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L602-10. PMID: 12740217.
      View in: PubMed
    45. Tsao K, Hawgood S, Vu L, Hirose S, Sydorak R, Albanese CT, Farmer DL, Harrison MR, Lee H. Resolution of hydrops fetalis in congenital cystic adenomatoid malformation after prenatal steroid therapy. J Pediatr Surg. 2003 Mar; 38(3):508-10. PMID: 12632377.
      View in: PubMed
    46. Keller RL, Aaroz PA, Hawgood S, Higgins CB. MR imaging of hepatic pulmonary fusion in neonates. AJR Am J Roentgenol. 2003 Feb; 180(2):438-40. PMID: 12540449.
      View in: PubMed
    47. Jain D, Dodia C, Bates SR, Hawgood S, Poulain FR, Fisher AB. SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L759-65. PMID: 12676766.
      View in: PubMed
    48. Hawgood S, Ochs M, Jung A, Akiyama J, Allen L, Brown C, Edmondson J, Levitt S, Carlson E, Gillespie AM, Villar A, Epstein CJ, Poulain FR. Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1002-10. PMID: 12376353.
      View in: PubMed
    49. Clark H, Palaniyar N, Strong P, Edmondson J, Hawgood S, Reid KB. Surfactant protein D reduces alveolar macrophage apoptosis in vivo. J Immunol. 2002 Sep 15; 169(6):2892-9. PMID: 12218102.
      View in: PubMed
    50. Yang S, Milla C, Panoskaltsis-Mortari A, Hawgood S, Blazar BR, Haddad IY. Surfactant protein A decreases lung injury and mortality after murine marrow transplantation. Am J Respir Cell Mol Biol. 2002 Sep; 27(3):297-305. PMID: 12204891.
      View in: PubMed
    51. Akiyama J, Hoffman A, Brown C, Allen L, Edmondson J, Poulain F, Hawgood S. Tissue distribution of surfactant proteins A and D in the mouse. J Histochem Cytochem. 2002 Jul; 50(7):993-6. PMID: 12070278.
      View in: PubMed
    52. Li G, Siddiqui J, Hendry M, Akiyama J, Edmondson J, Brown C, Allen L, Levitt S, Poulain F, Hawgood S. Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus. Am J Respir Cell Mol Biol. 2002 Mar; 26(3):277-82. PMID: 11867335.
      View in: PubMed
    53. Ochs M, Johnen G, Müller KM, Wahlers T, Hawgood S, Richter J, Brasch F. Intracellular and intraalveolar localization of surfactant protein A (SP-A) in the parenchymal region of the human lung. Am J Respir Cell Mol Biol. 2002 Jan; 26(1):91-8. PMID: 11751208.
      View in: PubMed