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Keith Yamamoto, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentCellular Molecular Pharmacology
Address600 16th St
San Francisco CA 94158
Phone415-476-3128
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    Other Positions
    TitleVice Chancellor for Science Policy and Strategy
    InstitutionUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology

    TitleDirector, UCSF Precision Medicine
    InstitutionUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology


    Collapse Overview 
    Collapse Overview
    Dr. Yamamoto oversees strategic planning as well as research activities at UCSF's school of medicine. After earning a PhD at Princeton, he came to UCSF in 1973. He served as chair of the Department of Cellular and Molecular Pharmacology from 1994 to 2003. Dr. Yamamoto is regarded as an international leader in studying the mechanisms of signaling and gene regulation by intracellular receptors.


    Collapse Research 
    Collapse Research Activities and Funding
    Transporters for Glucocorticoids: Exploring a New Paradigm for Steroid Hormone Regulation, and a Potential Strategy for Identification of Toxin/Disruptor Transporter Machineries
    NIH/NIEHS R21ES026068Aug 5, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Motivating INformed Decisions (MIND): Careers for the Future Biomedical Workforce
    NIH DP7OD018420Sep 20, 2013 - Aug 31, 2018
    Role: Co-Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH/NIDDK P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Co-Investigator
    GORDON RESEARCH CONFERENCE ON ANIMAL CELLS &VIRUSES
    NIH/NIGMS R13GM048082Jun 15, 1992 - Jun 14, 1993
    Role: Principal Investigator
    MOLECULAR BIOLOGY STUDY SECTION
    NIH/CSR U09RG014629Jul 1, 1984 - Jun 30, 1991
    Role: Co-Principal Investigator
    Gene Regulation By Steroid Receptor Proteins
    NIH/NCI R01CA020535Dec 1, 1976 - Jun 30, 2017
    Role: Principal Investigator
    GENE REGULATION BY STEROID RECEPTOR PROTEINS
    NIH/NCI R37CA020535Dec 1, 1976 - Nov 30, 1999
    Role: Principal Investigator
    Molecular Biology of Eukaryotic Cells and Viruses
    NIH/NCI T32CA009270Sep 1, 1976 - Jun 30, 2006
    Role: Co-Principal Investigator

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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Love MI, Huska MR, Jurk M, Schöpflin R, Starick SR, Schwahn K, Cooper SB, Yamamoto K, Thomas-Chollier M, Vingron M, Meijsing SH. Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation. Nucleic Acids Res. 2017 Feb 28; 45(4):1805-1819. PMID: 27903902.
      View in: PubMed
    2. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto K, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. PMID: 28192788.
      View in: PubMed
    3. Walter P, Yamamoto K. Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions. Cell. 2016 Sep 22; 167(1):16-19. PMID: 27634318.
      View in: PubMed
    4. Ratnappan R, Ward JD, Yamamoto K, Ghazi A. Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. Worm. 2016 Jan-Mar; 5(1):e1151609. PMID: 27073739; PMCID: PMC4805359 [Available on 02/18/17].
    5. Pack LR, Yamamoto K, Fujimori DG. Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C). J Biol Chem. 2016 Mar 18; 291(12):6060-70. PMID: 26747609; PMCID: PMC4813556 [Available on 03/18/17].
    6. Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto K. Precision medicine: Beyond the inflection point. Sci Transl Med. 2015 Aug 12; 7(300):300ps17. PMID: 26268311.
      View in: PubMed
    7. Granner DK, Wang JC, Yamamoto K. Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms. Adv Exp Med Biol. 2015; 872:3-31. PMID: 26215988.
      View in: PubMed
    8. Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto K, Olsen CP, Ghazi A. Germline signals deploy NHR-49 to modulate fatty-acid ß-oxidation and desaturation in somatic tissues of C. elegans. PLoS Genet. 2014 Dec; 10(12):e1004829. PMID: 25474470; PMCID: PMC4256272.
    9. Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto K. Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biol. 2014 Jul 31; 15(7):418. PMID: 25085117; PMCID: PMC4149261.
    10. Ward JD, Yamamoto K, Asahina M. SUMO as a nuclear hormone receptor effector: New insights into combinatorial transcriptional regulation. Worm. 2014; 3:e29317. PMID: 25254154; PMCID: PMC4165532.
    11. Ward JD, Mullaney B, Schiller BJ, He le D, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto K. Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One. 2014; 9(3):e92552. PMID: 24651852; PMCID: PMC3961378.
    12. Chodankar R, Wu DY, Schiller BJ, Yamamoto K, Stallcup MR. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12. PMID: 24591583; PMCID: PMC3964041.
    13. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto K. Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. PLoS Genet. 2013; 9(12):e1003992. PMID: 24348269; PMCID: PMC3861103.
    14. Thomas-Chollier M, Watson LC, Cooper SB, Pufall MA, Liu JS, Borzym K, Vingron M, Yamamoto K, Meijsing SH. A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17826-31. PMID: 24127590; PMCID: PMC3816441.
    15. Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto K. The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol. 2013 Jul; 20(7):876-83. PMID: 23728292; PMCID: PMC3702670.
    16. O'Brien T, Yamamoto K, Hawgood S. Commentary: Team science. Acad Med. 2013 Feb; 88(2):156-7. PMID: 23361027.
      View in: PubMed
    17. Chen SH, Masuno K, Cooper SB, Yamamoto K. Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1964-9. PMID: 23307810; PMCID: PMC3562826.
    18. Norman TC, Bountra C, Edwards AM, Yamamoto K, Friend SH. Leveraging crowdsourcing to facilitate the discovery of new medicines. Sci Transl Med. 2011 Jun 22; 3(88):88mr1. PMID: 21697527.
      View in: PubMed
    19. Engel KB, Yamamoto K. The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner. Mol Cell Biol. 2011 Aug; 31(16):3267-76. PMID: 21646426; PMCID: PMC3147806.
    20. Holdorf MM, Cooper SB, Yamamoto K, Miranda JJ. Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology. 2011 Jun 20; 415(1):1-5. PMID: 21550623; PMCID: PMC3808970.
    21. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto K, Ladner RD, Kahn M, Kim JH, Stallcup MR. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70. PMID: 21478268; PMCID: PMC3096696.
    22. Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto K, Leitman DC. Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes. J Immunol. 2011 Apr 01; 186(7):4354-60. PMID: 21357268.
      View in: PubMed
    23. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto K, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70. PMID: 21228270; PMCID: PMC3058992.
    24. Huff JT, Plocik AM, Guthrie C, Yamamoto K. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 Dec; 17(12):1495-9. PMID: 21057525; PMCID: PMC3057557.
    25. DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto K, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010 Aug; 20(8):1133-42. PMID: 20508142; PMCID: PMC2909576.
    26. Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto K, Walhout AJ. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol. 2010 May 11; 6:367. PMID: 20461074; PMCID: PMC2890327.
    27. Taubert S, Ward JD, Yamamoto K. Nuclear hormone receptors in nematodes: evolution and function. Mol Cell Endocrinol. 2011 Mar 01; 334(1-2):49-55. PMID: 20438802; PMCID: PMC3042524.
    28. Beck IM, Vanden Berghe W, Vermeulen L, Yamamoto K, Haegeman G, De Bosscher K. Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev. 2009 Dec; 30(7):830-82. PMID: 19890091; PMCID: PMC2818158.
    29. So AY, Bernal TU, Pillsbury ML, Yamamoto K, Feldman BJ. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7. PMID: 19805059; PMCID: PMC2757402.
    30. Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto K. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science. 2009 Apr 17; 324(5925):407-10. PMID: 19372434; PMCID: PMC2777810.
    31. Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto K, Hann B, Diamond MI. Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7233-8. PMID: 19363158; PMCID: PMC2678452.
    32. Pantoja C, Huff JT, Yamamoto K. Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro. Mol Biol Cell. 2008 Oct; 19(10):4032-41. PMID: 18653467; PMCID: PMC2555927.
    33. So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto K. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9. PMID: 18408151; PMCID: PMC2311370.
    34. Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto K. The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet. 2008 Feb 29; 4(2):e1000021. PMID: 18454197; PMCID: PMC2265483.
    35. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto K, Fahy JV. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15858-63. PMID: 17898169; PMCID: PMC2000427.
    36. Bolton EC, So AY, Chaivorapol C, Haqq CM, Li H, Yamamoto K. Cell- and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev. 2007 Aug 15; 21(16):2005-17. PMID: 17699749; PMCID: PMC1948856.
    37. So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto K. Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet. 2007 Jun; 3(6):e94. PMID: 17559307; PMCID: PMC1904358.
    38. Meijsing SH, Elbi C, Luecke HF, Hager GL, Yamamoto K. The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release. Mol Cell Biol. 2007 Apr; 27(7):2442-51. PMID: 17261597; PMCID: PMC1899895.
    39. Feldman BJ, Streeper RS, Farese RV, Yamamoto K. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80. PMID: 17030820; PMCID: PMC1592529.
    40. Taubert S, Van Gilst MR, Hansen M, Yamamoto K. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 2006 May 01; 20(9):1137-49. PMID: 16651656; PMCID: PMC1472473.
    41. Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto K. Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 2006 Mar 15; 20(6):689-99. PMID: 16543221; PMCID: PMC1413289.
    42. Lo B, Zettler P, Cedars MI, Gates E, Kriegstein AR, Oberman M, Reijo Pera R, Wagner RM, Wuerth MT, Wolf LE, Yamamoto K. A new era in the ethics of human embryonic stem cell research. Stem Cells. 2005 Nov-Dec; 23(10):1454-9. PMID: 16293581.
      View in: PubMed
    43. Van Gilst MR, Hadjivassiliou H, Yamamoto K. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13496-501. PMID: 16157872; PMCID: PMC1201344.
    44. Luecke HF, Yamamoto K. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 2005 May 01; 19(9):1116-27. PMID: 15879558; PMCID: PMC1091745.
    45. Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto K. Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol. 2005 Feb; 3(2):e53. PMID: 15719061; PMCID: PMC547972.
    46. Shostak Y, Yamamoto K. Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain. J Biol Chem. 2005 Feb 25; 280(8):6554-60. PMID: 15611047.
      View in: PubMed
    47. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto K. Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15603-8. PMID: 15501915; PMCID: PMC524211.
    48. Yamamoto K. Bankrolling stem-cell research with California dollars. N Engl J Med. 2004 Oct 21; 351(17):1711-3. PMID: 15496617.
      View in: PubMed
    49. Shostak Y, Van Gilst MR, Antebi A, Yamamoto K. Identification of C. elegans DAF-12-binding sites, response elements, and target genes. Genes Dev. 2004 Oct 15; 18(20):2529-44. PMID: 15489294; PMCID: PMC529540.
    50. Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto K. Informed consent in human oocyte, embryo, and embryonic stem cell research. Fertil Steril. 2004 Sep; 82(3):559-63. PMID: 15374695.
      View in: PubMed
    51. Wang JC, Walker A, Blackwell TK, Yamamoto K. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 09; 279(28):29270-7. PMID: 15073178.
      View in: PubMed
    52. Freedman ND, Yamamoto K. Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell. 2004 May; 15(5):2276-86. PMID: 15004228; PMCID: PMC404022.
    53. Tee MK, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy RJ, Yamamoto K, Leitman DC. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar; 15(3):1262-72. PMID: 14699072; PMCID: PMC363122.
    54. Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto K. Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13845-50. PMID: 14617768; PMCID: PMC283509.
    55. Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto K. Medicine. Consent from donors for embryo and stem cell research. Science. 2003 Aug 15; 301(5635):921. PMID: 12920284.
      View in: PubMed
    56. Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzburg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E, Yamamoto K. Statement on scientific publication and security. Science. 2003 Feb 21; 299(5610):1149. PMID: 12595658.
      View in: PubMed
    57. Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzberg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E, Yamamoto K. Statement on the consideration of biodefence and biosecurity. Nature. 2003 Feb 20; 421(6925):771. PMID: 12594463.
      View in: PubMed
    58. Rogatsky I, Luecke HF, Leitman DC, Yamamoto K. Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16701-6. PMID: 12481024; PMCID: PMC139207.
    59. Freeman BC, Yamamoto K. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 2002 Jun 21; 296(5576):2232-5. PMID: 12077419.
      View in: PubMed
    60. van Tilborg MA, Lefstin JA, Kruiskamp M, Teuben J, Boelens R, Yamamoto K, Kaptein R. Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA. J Mol Biol. 2000 Aug 25; 301(4):947-58. PMID: 10966797.
      View in: PubMed
    61. Alberts BM, Ayala FJ, Botstein D, Frank E, Holmes EW, Lee RD, Macagno ER, Marrack P, Oparil S, Orkin SH, Rubenstein AH, Slayman CW, Sparling PF, Squire LR, von Hippel PH, Yamamoto K. Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science. 1999 Jul 30; 285(5428):666-7. PMID: 10454921.
      View in: PubMed
    62. Miller ME, Cairns BR, Levinson RS, Yamamoto K, Engel DA, Smith MM. Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation. Mol Cell Biol. 1996 Oct; 16(10):5737-43. PMID: 8816487; PMCID: PMC231574.
    63. Xu M, Chakraborti PK, Garabedian MJ, Yamamoto K, Simons SS. Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains. J Biol Chem. 1996 Aug 30; 271(35):21430-8. PMID: 8702925.
      View in: PubMed
    64. Bohen SP, Kralli A, Yamamoto K. Hold 'em and fold 'em: chaperones and signal transduction. Science. 1995 Jun 02; 268(5215):1303-4. PMID: 7761850.
      View in: PubMed
    65. van Tilborg MA, Bonvin AM, Hård K, Davis AL, Maler B, Boelens R, Yamamoto K, Kaptein R. Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations. J Mol Biol. 1995 Apr 07; 247(4):689-700. PMID: 7723024.
      View in: PubMed
    66. Scherrer LC, Picard D, Massa E, Harmon JM, Simons SS, Yamamoto K, Pratt WB. Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90. Biochemistry. 1993 May 25; 32(20):5381-6. PMID: 8499442.
      View in: PubMed
    67. Imai E, Miner JN, Mitchell JA, Yamamoto K, Granner DK. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J Biol Chem. 1993 Mar 15; 268(8):5353-6. PMID: 8449898.
      View in: PubMed
    68. Chakraborti PK, Garabedian MJ, Yamamoto K, Simons SS. Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors. J Biol Chem. 1992 Jun 05; 267(16):11366-73. PMID: 1597467.
      View in: PubMed
    69. Amero SA, Kretsinger RH, Moncrief ND, Yamamoto K, Pearson WR. The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol Endocrinol. 1992 Jan; 6(1):3-7. PMID: 1738368.
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    70. Remerowski ML, Kellenbach E, Boelens R, van der Marel GA, van Boom JH, Maler BA, Yamamoto K, Kaptein R. 1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element. Biochemistry. 1991 Dec 17; 30(50):11620-4. PMID: 1751485.
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    71. Chakraborti PK, Garabedian MJ, Yamamoto K, Simons SS. Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain. J Biol Chem. 1991 Nov 25; 266(33):22075-8. PMID: 1939229.
      View in: PubMed
    72. Kellenbach E, Maler BA, Yamamoto K, Boelens R, Kaptein R. Identification of the metal coordinating residues in the DNA binding domain of the glucocorticoid receptor by 113Cd-1H heteronuclear NMR spectroscopy. FEBS Lett. 1991 Oct 21; 291(2):367-70. PMID: 1936288.
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    73. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto K, Sigler PB. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 1991 Aug 08; 352(6335):497-505. PMID: 1865905.
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    74. Kellenbach E, Härd T, Boelens R, Dahlman K, Carlstedt-Duke J, Gustafsson JA, van der Marel GA, van Boom JH, Maler B, Yamamoto K. Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements. J Biomol NMR. 1991 May; 1(1):105-10. PMID: 1841686.
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    75. Schena M, Picard D, Yamamoto K. Vectors for constitutive and inducible gene expression in yeast. Methods Enzymol. 1991; 194:389-98. PMID: 2005799.
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    76. Privalsky ML, Sharif M, Yamamoto K. The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell. 1990 Dec 21; 63(6):1277-86. PMID: 1979758.
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    77. Howard KJ, Holley SJ, Yamamoto K, Distelhorst CW. Mapping the HSP90 binding region of the glucocorticoid receptor. J Biol Chem. 1990 Jul 15; 265(20):11928-35. PMID: 2365707.
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    78. Härd T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto K, Gustafsson JA, Kaptein R. Solution structure of the glucocorticoid receptor DNA-binding domain. Science. 1990 Jul 13; 249(4965):157-60. PMID: 2115209.
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    79. Schena M, Freedman LP, Yamamoto K. Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes Dev. 1989 Oct; 3(10):1590-601. PMID: 2515114.
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    80. Eilers M, Picard D, Yamamoto K, Bishop JM. Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature. 1989 Jul 06; 340(6228):66-8. PMID: 2662015.
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    81. Freedman LP, Yamamoto K, Luisi BF, Sigler PB. More fingers in hand. Cell. 1988 Aug 12; 54(4):444. PMID: 3401923.
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    82. Rusconi S, Yamamoto K. Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J. 1987 May; 6(5):1309-15. PMID: 2440676; PMCID: PMC553934.
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