Keith Yamamoto, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th Street, #S572D
San Francisco CA 94158
Phone415-476-8445
ORCID ORCID Icon0000-0001-6766-335X Additional info
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    Other Positions
    Title(s)Vice Chancellor for Science Policy and Strategy

    Title(s)Director, UCSF Precision Medicine


    Collapse Overview 
    Collapse Overview
    Dr. Yamamoto oversees strategic planning as well as research activities at UCSF's school of medicine. After earning a PhD at Princeton, he came to UCSF in 1973. He served as chair of the Department of Cellular and Molecular Pharmacology from 1994 to 2003. Dr. Yamamoto is regarded as an international leader in studying the mechanisms of signaling and gene regulation by intracellular receptors. Dr. Yamamoto currently serves as the Vice Chancellor for Science Policy and Strategy and the Director of Precision Medicine at UCSF.

    In 2022, Yamamoto was elected president of the American Association for the Advancement of Science, the largest multidisciplinary scientific society in the world.
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    Collapse Research 
    Collapse Research Activities and Funding
    CasCUT&RUN: An in vivo method to analyze locus-specific protein complexes driving transcription of target genes in cancer
    NIH R21CA235303Feb 15, 2019 - Jan 31, 2022
    Role: Principal Investigator
    Transporters for Glucocorticoids: Exploring a New Paradigm for Steroid Hormone Regulation, and a Potential Strategy for Identification of Toxin/Disruptor Transporter Machineries
    NIH R21ES026068Aug 5, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Motivating INformed Decisions (MIND): Careers for the Future Biomedical Workforce
    NIH DP7OD018420Sep 20, 2013 - Nov 30, 2019
    Role: Co-Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Co-Investigator
    GORDON RESEARCH CONFERENCE ON ANIMAL CELLS &VIRUSES
    NIH R13GM048082Jun 15, 1992 - Jun 14, 1993
    Role: Principal Investigator
    MOLECULAR BIOLOGY STUDY SECTION
    NIH U09RG014629Jul 1, 1984 - Jun 30, 1991
    Role: Co-Principal Investigator
    Gene Regulation By Steroid Receptor Proteins
    NIH R01CA020535Dec 1, 1976 - Nov 30, 2018
    Role: Principal Investigator
    GENE REGULATION BY STEROID RECEPTOR PROTEINS
    NIH R37CA020535Dec 1, 1976 - Nov 30, 1999
    Role: Principal Investigator
    Molecular Biology of Eukaryotic Cells and Viruses
    NIH T32CA009270Sep 1, 1976 - Jun 30, 2006
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Help wanted, scientists need apply. Science. 2024 Feb 09; 383(6683):571. Yamamoto KR. PMID: 38330112.
      View in: PubMed   Mentions:    Fields:    
    2. Embed equity throughout innovation. Science. 2023 Sep 08; 381(6662):1029. Wailoo KA, Dzau VJ, Yamamoto KR. PMID: 37676960.
      View in: PubMed   Mentions: 1     Fields:    
    3. Institutions' role in trainee success. Science. 2023 Mar 31; 379(6639):1308. Yamamoto KR. PMID: 36996226.
      View in: PubMed   Mentions:    Fields:    
    4. Computational resources to define alleles and altered regulatory motifs at genomically edited candidate response elements. Nucleic Acids Res. 2021 09 20; 49(16):9117-9131. Ehmsen KT, Knuesel MT, Martinez D, Asahina M, Aridomi H, Yamamoto KR. PMID: 34417596; PMCID: PMC8450113.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Time for NIH to lead on data sharing. Science. 2020 03 20; 367(6484):1308-1309. Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R. PMID: 32193313.
      View in: PubMed   Mentions: 23     Fields:    
    6. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 08; 34(8):2025-2037. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. PMID: 32066867; PMCID: PMC7440098.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    7. A New Tool for Inducible Gene Expression in Caenorhabditis elegans. Genetics. 2019 02; 211(2):419-430. Monsalve GC, Yamamoto KR, Ward JD. PMID: 30504365; PMCID: PMC6366904.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    8. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 29849140.
      View in: PubMed   Mentions:    Fields:    
    9. Internship Experiences Contribute to Confident Career Decision Making for Doctoral Students in the Life Sciences. CBE Life Sci Educ. 2018; 17(1). Schnoes AM, Caliendo A, Morand J, Dillinger T, Naffziger-Hirsch M, Moses B, Gibeling JC, Yamamoto KR, Lindstaedt B, McGee R, O'Brien TC. PMID: 29449270; PMCID: PMC6007763.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    10. Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation. Nucleic Acids Res. 2017 02 28; 45(4):1805-1819. Love MI, Huska MR, Jurk M, Schöpflin R, Starick SR, Schwahn K, Cooper SB, Yamamoto KR, Thomas-Chollier M, Vingron M, Meijsing SH. PMID: 27903902; PMCID: PMC5389550.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    11. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 28192788; PMCID: PMC5621518.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    12. Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nat Rev Mol Cell Biol. 2017 03; 18(3):159-174. Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR. PMID: 28053348; PMCID: PMC6257982.
      View in: PubMed   Mentions: 237     Fields:    Translation:HumansAnimalsCells
    13. Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions. Cell. 2016 Sep 22; 167(1):16-19. Walter P, Yamamoto KR. PMID: 27634318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. Worm. 2016 Jan-Mar; 5(1):e1151609. Ratnappan R, Ward JD, Yamamoto KR, Ghazi A. PMID: 27073739; PMCID: PMC4805359.
      View in: PubMed   Mentions: 5  
    15. Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C). J Biol Chem. 2016 Mar 18; 291(12):6060-70. Pack LR, Yamamoto KR, Fujimori DG. PMID: 26747609; PMCID: PMC4813556.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Precision medicine: Beyond the inflection point. Sci Transl Med. 2015 Aug 12; 7(300):300ps17. Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto KR. PMID: 26268311.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    17. Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms. Adv Exp Med Biol. 2015; 872:3-31. Granner DK, Wang JC, Yamamoto KR. PMID: 26215988.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    18. Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans. PLoS Genet. 2014 Dec; 10(12):e1004829. Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto KR, Olsen CP, Ghazi A. PMID: 25474470; PMCID: PMC4256272.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    19. Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biol. 2014 Jul 31; 15(7):418. Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto KR. PMID: 25085117; PMCID: PMC4149261.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    20. SUMO as a nuclear hormone receptor effector: New insights into combinatorial transcriptional regulation. Worm. 2014; 3:e29317. Ward JD, Yamamoto KR, Asahina M. PMID: 25254154; PMCID: PMC4165532.
      View in: PubMed   Mentions: 2  
    21. Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One. 2014; 9(3):e92552. Ward JD, Mullaney B, Schiller BJ, He LD, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR. PMID: 24651852; PMCID: PMC3961378.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12. Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup MR. PMID: 24591583; PMCID: PMC3964041.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    23. Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. PLoS Genet. 2013; 9(12):e1003992. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. PMID: 24348269; PMCID: PMC3861103.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17826-31. Thomas-Chollier M, Watson LC, Cooper SB, Pufall MA, Liu JS, Borzym K, Vingron M, Yamamoto KR, Meijsing SH. PMID: 24127590; PMCID: PMC3816441.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    25. The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol. 2013 Jul; 20(7):876-83. Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR. PMID: 23728292; PMCID: PMC3702670.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    26. Commentary: Team science. Acad Med. 2013 Feb; 88(2):156-7. O'Brien T, Yamamoto K, Hawgood S. PMID: 23361027.
      View in: PubMed   Mentions: 4     Fields:    
    27. Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1964-9. Chen SH, Masuno K, Cooper SB, Yamamoto KR. PMID: 23307810; PMCID: PMC3562826.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    28. Leveraging crowdsourcing to facilitate the discovery of new medicines. Sci Transl Med. 2011 Jun 22; 3(88):88mr1. Norman TC, Bountra C, Edwards AM, Yamamoto KR, Friend SH. PMID: 21697527.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    29. The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner. Mol Cell Biol. 2011 Aug; 31(16):3267-76. Engel KB, Yamamoto KR. PMID: 21646426; PMCID: PMC3147806.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    30. Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology. 2011 Jun 20; 415(1):1-5. Holdorf MM, Cooper SB, Yamamoto KR, Miranda JJ. PMID: 21550623; PMCID: PMC3808970.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    31. A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR. PMID: 21478268; PMCID: PMC3096696.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    32. Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes. J Immunol. 2011 Apr 01; 186(7):4354-60. Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC. PMID: 21357268.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    33. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. PMID: 21228270; PMCID: PMC3058992.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    34. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 Dec; 17(12):1495-9. Huff JT, Plocik AM, Guthrie C, Yamamoto KR. PMID: 21057525; PMCID: PMC3057557.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    35. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010 Aug; 20(8):1133-42. DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD. PMID: 20508142; PMCID: PMC2909576.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    36. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol. 2010 May 11; 6:367. Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJ. PMID: 20461074; PMCID: PMC2890327.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    37. Nuclear hormone receptors in nematodes: evolution and function. Mol Cell Endocrinol. 2011 Mar 01; 334(1-2):49-55. Taubert S, Ward JD, Yamamoto KR. PMID: 20438802; PMCID: PMC3042524.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    38. Integrated biology and undergraduate science education: a new biology education for the twenty-first century? CBE Life Sci Educ. 2010; 9(1):10-6. Labov JB, Reid AH, Yamamoto KR. PMID: 20194802; PMCID: PMC2830155.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    39. Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev. 2009 Dec; 30(7):830-82. Beck IM, Vanden Berghe W, Vermeulen L, Yamamoto KR, Haegeman G, De Bosscher K. PMID: 19890091; PMCID: PMC2818158.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    40. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7. So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. PMID: 19805059; PMCID: PMC2757402.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    41. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science. 2009 Apr 17; 324(5925):407-10. Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR. PMID: 19372434; PMCID: PMC2777810.
      View in: PubMed   Mentions: 356     Fields:    Translation:HumansAnimalsCells
    42. Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7233-8. Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. PMID: 19363158; PMCID: PMC2678452.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    43. Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro. Mol Biol Cell. 2008 Oct; 19(10):4032-41. Pantoja C, Huff JT, Yamamoto KR. PMID: 18653467; PMCID: PMC2555927.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    44. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9. So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. PMID: 18408151; PMCID: PMC2311370.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    45. The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet. 2008 Feb 29; 4(2):e1000021. Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR. PMID: 18454197; PMCID: PMC2265483.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    46. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15858-63. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. PMID: 17898169; PMCID: PMC2000427.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansCells
    47. Cell- and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev. 2007 Aug 15; 21(16):2005-17. Bolton EC, So AY, Chaivorapol C, Haqq CM, Li H, Yamamoto KR. PMID: 17699749; PMCID: PMC1948856.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    48. Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet. 2007 Jun; 3(6):e94. So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR. PMID: 17559307; PMCID: PMC1904358.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    49. The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release. Mol Cell Biol. 2007 Apr; 27(7):2442-51. Meijsing SH, Elbi C, Luecke HF, Hager GL, Yamamoto KR. PMID: 17261597; PMCID: PMC1899895.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    50. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80. Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. PMID: 17030820; PMCID: PMC1592529.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    51. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 2006 May 01; 20(9):1137-49. Taubert S, Van Gilst MR, Hansen M, Yamamoto KR. PMID: 16651656; PMCID: PMC1472473.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    52. Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 2006 Mar 15; 20(6):689-99. Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR. PMID: 16543221; PMCID: PMC1413289.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    53. A new era in the ethics of human embryonic stem cell research. Stem Cells. 2005 Nov-Dec; 23(10):1454-9. Lo B, Zettler P, Cedars MI, Gates E, Kriegstein AR, Oberman M, Reijo Pera R, Wagner RM, Wuerth MT, Wolf LE, Yamamoto KR. PMID: 16293581.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    54. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13496-501. Van Gilst MR, Hadjivassiliou H, Yamamoto KR. PMID: 16157872; PMCID: PMC1201344.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    55. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 2005 May 01; 19(9):1116-27. Luecke HF, Yamamoto KR. PMID: 15879558; PMCID: PMC1091745.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    56. Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol. 2005 Feb; 3(2):e53. Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR. PMID: 15719061; PMCID: PMC547972.
      View in: PubMed   Mentions: 220     Fields:    Translation:AnimalsCells
    57. Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain. J Biol Chem. 2005 Feb 25; 280(8):6554-60. Shostak Y, Yamamoto KR. PMID: 15611047.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    58. Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15603-8. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR. PMID: 15501915; PMCID: PMC524211.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    59. Bankrolling stem-cell research with California dollars. N Engl J Med. 2004 Oct 21; 351(17):1711-3. Yamamoto KR. PMID: 15496617.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    60. Identification of C. elegans DAF-12-binding sites, response elements, and target genes. Genes Dev. 2004 Oct 15; 18(20):2529-44. Shostak Y, Van Gilst MR, Antebi A, Yamamoto KR. PMID: 15489294; PMCID: PMC529540.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    61. Informed consent in human oocyte, embryo, and embryonic stem cell research. Fertil Steril. 2004 Sep; 82(3):559-63. Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto KR. PMID: 15374695.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    62. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 09; 279(28):29270-7. Wang JC, Walker A, Blackwell TK, Yamamoto KR. PMID: 15073178.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    63. Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell. 2004 May; 15(5):2276-86. Freedman ND, Yamamoto KR. PMID: 15004228; PMCID: PMC404022.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    64. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar; 15(3):1262-72. Tee MK, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy RJ, Yamamoto KR, Leitman DC. PMID: 14699072; PMCID: PMC363122.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    65. Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13845-50. Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto KR. PMID: 14617768; PMCID: PMC283509.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    66. Medicine. Consent from donors for embryo and stem cell research. Science. 2003 Aug 15; 301(5635):921. Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto KR. PMID: 12920284.
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    67. Statement on scientific publication and security. Science. 2003 02 21; 299(5610):1149. Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzberg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E, Yamamoto K, Journal Editors and Authors Group. PMID: 12595658.
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    68. Statement on the consideration of biodefence and biosecurity. Nature. 2003 Feb 20; 421(6925):771. Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzberg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E, Yamamoto K, Journal Editors and Authors Group. PMID: 12594463.
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    69. Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16701-6. Rogatsky I, Luecke HF, Leitman DC, Yamamoto KR. PMID: 12481024; PMCID: PMC139207.
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    70. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 2002 Jun 21; 296(5576):2232-5. Freeman BC, Yamamoto KR. PMID: 12077419.
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    71. Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA. J Mol Biol. 2000 Aug 25; 301(4):947-58. van Tilborg MA, Lefstin JA, Kruiskamp M, Teuben J, Boelens R, Yamamoto KR, Kaptein R. PMID: 10966797.
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    72. Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science. 1999 Jul 30; 285(5428):666-7. Alberts BM, Ayala FJ, Botstein D, Frank E, Holmes EW, Lee RD, Macagno ER, Marrack P, Oparil S, Orkin SH, Rubenstein AH, Slayman CW, Sparling PF, Squire LR, von Hippel PH, Yamamoto KR. PMID: 10454921.
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    73. Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation. Mol Cell Biol. 1996 Oct; 16(10):5737-43. Miller ME, Cairns BR, Levinson RS, Yamamoto KR, Engel DA, Smith MM. PMID: 8816487; PMCID: PMC231574.
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    74. Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains. J Biol Chem. 1996 Aug 30; 271(35):21430-8. Xu M, Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS. PMID: 8702925.
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    75. Hold 'em and fold 'em: chaperones and signal transduction. Science. 1995 Jun 02; 268(5215):1303-4. Bohen SP, Kralli A, Yamamoto KR. PMID: 7761850.
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    76. Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations. J Mol Biol. 1995 Apr 07; 247(4):689-700. van Tilborg MA, Bonvin AM, Hård K, Davis AL, Maler B, Boelens R, Yamamoto KR, Kaptein R. PMID: 7723024.
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    77. Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90. Biochemistry. 1993 May 25; 32(20):5381-6. Scherrer LC, Picard D, Massa E, Harmon JM, Simons SS, Yamamoto KR, Pratt WB. PMID: 8499442.
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    78. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J Biol Chem. 1993 Mar 15; 268(8):5353-6. Imai E, Miner JN, Mitchell JA, Yamamoto KR, Granner DK. PMID: 8449898.
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    79. Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors. J Biol Chem. 1992 Jun 05; 267(16):11366-73. Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS. PMID: 1597467.
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    80. The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol Endocrinol. 1992 Jan; 6(1):3-7. Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR. PMID: 1738368.
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    81. 1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element. Biochemistry. 1991 Dec 17; 30(50):11620-4. Remerowski ML, Kellenbach E, Boelens R, van der Marel GA, van Boom JH, Maler BA, Yamamoto KR, Kaptein R. PMID: 1751485.
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    82. Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain. J Biol Chem. 1991 Nov 25; 266(33):22075-8. Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS. PMID: 1939229.
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    83. Identification of the metal coordinating residues in the DNA binding domain of the glucocorticoid receptor by 113Cd-1H heteronuclear NMR spectroscopy. FEBS Lett. 1991 Oct 21; 291(2):367-70. Kellenbach E, Maler BA, Yamamoto KR, Boelens R, Kaptein R. PMID: 1936288.
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    84. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 1991 Aug 08; 352(6335):497-505. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB. PMID: 1865905.
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    85. Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements. J Biomol NMR. 1991 May; 1(1):105-10. Kellenbach E, Härd T, Boelens R, Dahlman K, Carlstedt-Duke J, Gustafsson JA, van der Marel GA, van Boom JH, Maler B, Yamamoto KR, et al. PMID: 1841686.
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    86. Vectors for constitutive and inducible gene expression in yeast. Methods Enzymol. 1991; 194:389-98. Schena M, Picard D, Yamamoto KR. PMID: 2005799.
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    87. The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell. 1990 Dec 21; 63(6):1277-86. Privalsky ML, Sharif M, Yamamoto KR. PMID: 1979758.
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    88. Mapping the HSP90 binding region of the glucocorticoid receptor. J Biol Chem. 1990 Jul 15; 265(20):11928-35. Howard KJ, Holley SJ, Yamamoto KR, Distelhorst CW. PMID: 2365707.
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    89. Solution structure of the glucocorticoid receptor DNA-binding domain. Science. 1990 Jul 13; 249(4965):157-60. Härd T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA, Kaptein R. PMID: 2115209.
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    90. Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes Dev. 1989 Oct; 3(10):1590-601. Schena M, Freedman LP, Yamamoto KR. PMID: 2515114.
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    91. Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature. 1989 Jul 06; 340(6228):66-8. Eilers M, Picard D, Yamamoto KR, Bishop JM. PMID: 2662015.
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    92. More fingers in hand. Cell. 1988 Aug 12; 54(4):444. Freedman LP, Yamamoto KR, Luisi BF, Sigler PB. PMID: 3401923.
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    93. Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J. 1987 May; 6(5):1309-15. Rusconi S, Yamamoto KR. PMID: 2440676; PMCID: PMC553934.
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