Amy Lin, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-0554-2832 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto , Toronto, CAPhD2010 School of Graduate Studies, Department of Medical Biophysics
    University of Toronto , Toronto, CAMD2012Medicine
    University of Toronto, Toronto, CAResident2016Internal Medicine
    Brigham and Women's Hospital, Harvard Medical School, Boston, MAFellow2019Cardiovascular Disease
    Brigham and Women's Hospital, Harvard Medical School, Boston, MAPost-Doctoral Fellow2022Cardiovascular Disease
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MAPost-Doctoral Fellow2022Hematology and Oncology
    Collapse Awards and Honors
    Brigham and Women's Hospital, Dana Farber Cancer Institute2018  - 2020John S. LaDue Memorial Fellowship
    Dana Farber Cancer Institute, Brigham and Women's Hospital2020  - 2021American Society of Hematology Research Training Award for Fellows
    Brigham and Women's Hospital, Dana Farber Cancer Institute2021  - 2022American College of Cardiology (ACC) Merck Research Fellowship in Cardiovascular Disease

    Collapse Overview 
    Collapse Overview
    CLINICAL INTERESTS
    My clinical interests are in cardiology and cardio-oncology, which the care of cancer patients and preventing and managing cardiovascular issues that can arise from cancer therapies. My special interests include survivorship, including breast and prostate cancer, and clonal hematopoiesis of indeterminate potential or CHIP (mutations in stem cells of the blood) leading to cardiovascular disease. At UCSF, I am part of the Cardio-Oncology and Immunology Program.

    RESEARCH INTERESTS
    My research interests are in cardio-oncology, with focus on inflammation in cardiovascular disease and how CHIP can increase a patient’s risks for heart disease, heart failure and arrhythmias. Clonal hematopoiesis of indeterminate potential, or CHIP is an age-associated process, where mutations in a certain subset of genes, drives the selection and survival of clonal blood cell populations. CHIP is common, occurring in more than 10% of individuals over the age of 70 years, and as expected, is associated with the increased risk of blood cancers, including MDS, and leukemia. Emerging research has highlighted the association of CHIP and precursor disorders with an increased risk of cardiovascular disease. Individuals with CHIP have a 2-4-fold increased risk of cardiovascular disease, myocardial infarction and ischemic stroke, independent of traditional CVD risk factors, similar to the degree of risk conferred by smoking, hypertension, or elevated cholesterol. The genetic mutations underlying clonal hematopoiesis may contribute to an increase in inflammation and other processes that affect the health of heart tissue and blood vessels. My recent research work demonstrated individuals with CHIP are at increased risk of incident atrial fibrillation, associated with increased inflammasome activation.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human Plasma Proteomic Profile of Clonal Hematopoiesis. bioRxiv. 2024 Oct 31. Yu Z, Vromman A, Nguyen NQH, Schuermans A, Rentz T, Vellarikkal SK, Uddin MM, Niroula A, Griffin G, Honigberg MC, Lin AE, Gibson CJ, Katz DH, Tahir U, Fang S, Haidermota S, Ganesh S, Antoine T, Weinstock J, Austin TR, Ramachandran VS, Peloso GM, Hornsby W, Ganz P, Manson JE, Haring B, Kooperberg CL, Reiner AP, Bis JC, Psaty BM, Min YI, Correa A, Lange LA, Post WS, Rotter JI, Rich SS, Wilson JG, Ebert BL, Yu B, Ballantyne CM, Coresh J, Sankaran VG, Bick AG, Jaiswal S, Gerszten RE, NHLBI Trans-Omics for Precision Medicine, Libby P, Gupta RM, Natarajan P. PMID: 39554199; PMCID: PMC11565774.
      View in: PubMed   Mentions:
    2. Cardiovascular Considerations Before Cancer Therapy: Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations. JACC CardioOncol. 2024 Oct; 6(5):631-654. Raisi-Estabragh Z, Murphy AC, Ramalingam S, Scherrer-Crosbie M, Lopez-Fernandez T, Reynolds KL, Aznar M, Lin AE, Libby P, Cordoba R, Bredsen-Masley C, Wechalekar A, Apperley J, Cheng RK, Manisty CH. PMID: 39479317; PMCID: PMC11520216.
      View in: PubMed   Mentions:
    3. Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias. Eur Heart J. 2024 Mar 07; 45(10):791-805. Schuermans A, Vlasschaert C, Nauffal V, Cho SMJ, Uddin MM, Nakao T, Niroula A, Klarqvist MDR, Weeks LD, Lin AE, Saadatagah S, Lannery K, Wong M, Hornsby W, Lubitz SA, Ballantyne C, Jaiswal S, Libby P, Ebert BL, Bick AG, Ellinor PT, Natarajan P, Honigberg MC. PMID: 37952204; PMCID: PMC10919923.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    4. Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation. Circulation. 2024 Apr 30; 149(18):1419-1434. Lin AE, Bapat AC, Xiao L, Niroula A, Ye J, Wong WJ, Agrawal M, Farady CJ, Boettcher A, Hergott CB, McConkey M, Flores-Bringas P, Shkolnik V, Bick AG, Milan D, Natarajan P, Libby P, Ellinor PT, Ebert BL. PMID: 38357791; PMCID: PMC11058018.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes. Nat Cardiovasc Res. 2023 Sep; 2(9):805-818. Rauch PJ, Gopakumar J, Silver AJ, Nachun D, Ahmad H, McConkey M, Nakao T, Bosse M, Rentz T, Vivanco Gonzalez N, Greenwald NF, McCaffrey EF, Khair Z, Gopakumar M, Rodrigues KB, Lin AE, Sinha E, Fefer M, Cohen DN, Vromman A, Shvartz E, Sukhova G, Bendall S, Angelo M, Libby P, Ebert BL, Jaiswal S. PMID: 39196062.
      View in: PubMed   Mentions: 13  Translation:AnimalsCells
    6. Author Correction: Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023 Jul; 619(7970):E47. Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C, NHLBI TOPMed Hematology Working Group, Ebert BL, Natarajan P. PMID: 37400552.
      View in: PubMed   Mentions:    Fields:    
    7. Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023 Apr; 616(7958):747-754. Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C, NHLBI TOPMed Hematology Working Group, Ebert BL, Natarajan P. PMID: 37046084; PMCID: PMC10405350.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    8. TET2-mutant clonal hematopoiesis and risk of gout. Blood. 2022 09 08; 140(10):1094-1103. Agrawal M, Niroula A, Cunin P, McConkey M, Shkolnik V, Kim PG, Wong WJ, Weeks LD, Lin AE, Miller PG, Gibson CJ, Sekar A, Schaefer IM, Neuberg D, Stone RM, Bick AG, Uddin MM, Griffin GK, Jaiswal S, Natarajan P, Nigrovic PA, Rao DA, Ebert BL. PMID: 35714308; PMCID: PMC9461470.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    9. Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells. J Clin Invest. 2022 08 15; 132(16). Sellar RS, Sperling AS, Slabicki M, Gasser JA, McConkey ME, Donovan KA, Mageed N, Adams DN, Zou C, Miller PG, Dutta RK, Boettcher S, Lin AE, Sandoval B, Quevedo Barrios VA, Kovalcik V, Koeppel J, Henderson EK, Fink EC, Yang L, Chan A, Pokharel SP, Bergstrom EJ, Burt R, Udeshi ND, Carr SA, Fischer ES, Chen CW, Ebert BL. PMID: 35763353; PMCID: PMC9374383.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    10. Clonal Hematopoiesis: Confluence of Malignant and Nonmalignant Diseases. Annual Review of Cancer Biology. 2022; 6:187-200. Amy E. Lin, Philipp J. Rauch, Siddhartha Jaiswal, Benjamin L. Ebert. View Publication.
    11. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med. 2021 12 06; 218(12). Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. PMID: 34698806; PMCID: PMC8552148.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    12. Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2021 Mar; 591(7851):E27. Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Niroula A, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD, NHLBI Trans-Omics for Precision Medicine Consortium, Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S, Natarajan P. PMID: 33707633.
      View in: PubMed   Mentions: 2     Fields:    
    13. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 10; 586(7831):763-768. Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD, NHLBI Trans-Omics for Precision Medicine Consortium, Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S, Natarajan P. PMID: 33057201; PMCID: PMC7944936.
      View in: PubMed   Mentions: 274     Fields:    Translation:HumansCells
    14. The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor. JAMA Cardiol. 2020 08 01; 5(8):958-961. Sidlow R, Lin AE, Gupta D, Bolton KL, Steensma DP, Levine RL, Ebert BL, Libby P. PMID: 32459358.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    15. A new opening on aortic stenosis: predicting prognosis with clonal haematopoiesis. Eur Heart J. 2020 02 21; 41(8):940-942. Lin AE, Libby P, Ebert BL. PMID: 31634387.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 07 30; 74(4):567-577. Libby P, Sidlow R, Lin AE, Gupta D, Jones LW, Moslehi J, Zeiher A, Jaiswal S, Schulz C, Blankstein R, Bolton KL, Steensma D, Levine RL, Ebert BL. PMID: 31345432; PMCID: PMC6681657.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    17. CHIPping Away at the Pathogenesis of Heart Failure. JAMA Cardiol. 2019 01 01; 4(1):5-6. Libby P, Jaiswal S, Lin AE, Ebert BL. PMID: 30566187.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. J Immunol. 2017 12 15; 199(12):4056-4065. Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS. PMID: 29109121.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol. 2013 Jan; 14(1):27-33. Lin AE, Ebert G, Ow Y, Preston SP, Toe JG, Cooney JP, Scott HW, Sasaki M, Saibil SD, Dissanayake D, Kim RH, Wakeham A, You-Ten A, Shahinian A, Duncan G, Silvester J, Ohashi PS, Mak TW, Pellegrini M. PMID: 23179078.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    20. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 2011 Feb 18; 144(4):601-13. Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, DePinho RA, Basta S, Ohashi PS, Mak TW. PMID: 21295337.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    21. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med. 2009 May; 15(5):528-36. Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW. PMID: 19396174.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    22. The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells. Curr Opin Immunol. 2007 Dec; 19(6):665-73. Lin AE, Mak TW. PMID: 18036806.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
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